Moximed, Inc. is focused on developing joint-preserving solutions for patients suffering from knee osteoarthritis. The company's primary product, the Atlas System, functions as an implantable joint unloader, similar to a shock absorber, specifically targeting individuals experiencing pain in the medial compartment of the knee. This innovative approach aims to alleviate joint pain, reduce dynamic load, and potentially delay the necessity for more invasive surgical interventions. Moximed seeks to enhance the standard of care for osteoarthritis patients, helping them maintain an active lifestyle while serving both patients and medical professionals globally. Established in 2006 and headquartered in Hayward, California, Moximed was previously known as ExploraMed NC4, Inc.
Operator of a trailblazing biotechnology company intended to pioneer innovative and sustainable solutions for health and wellness. The company maximizes the inherent power of plants through the application of cutting-edge technologies, and its groundbreaking bioactive production platform, unlocks the extraordinary potential of nature's resources, crafting a wide array of premium products that enhance lives and foster well-being, enabling customers to be provided with health tools through products that combine natural substances, science, and technology while respecting nature and the environment.
Private Equity Round in 2021
80/20 is a world-class originator and manufacturer of aluminum T-slotted building systems for various applications and end-markets. 80/20 provides T-slot aluminum profiles, or bars, that have channels used to connect other bars and parts — for instance, panels, linear bearings, or casters. It is a building system anyone can use to create custom solutions.
MSHS Group consistently provides turnkey solutions for the Maritime, Oil & Gas and Stationary Power Industries.
SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for treating chronic inflammatory diseases, including rheumatoid arthritis and Crohn's Disease. The company leverages the Inflammatory Reflex, a natural mechanism that allows the central nervous system to regulate the immune system, which has been extensively studied and documented in scientific literature. SetPoint's proprietary microregulator aims to enhance this reflex through vagus nerve stimulation, offering an alternative treatment option that provides systemic anti-inflammatory effects. The devices are designed to supplement the body's natural responses and are expected to deliver comparable anti-inflammatory potency to leading medications, while potentially offering improved safety and lower costs. Currently, SetPoint is conducting human trials for its technology at multiple centers in Europe.
MSHS Group consistently provides turnkey solutions for the Maritime, Oil & Gas and Stationary Power Industries.
Waterfront Brands is a manufacturer based in Fergus Falls, Minnesota, specializing in a comprehensive range of premium boating products for both fresh and saltwater environments. The company produces and distributes a variety of waterfront equipment, including aluminum and steel docks, aluminum boat lifts, and plastic floating docks. By offering a diverse lineup of products, Waterfront Brands caters to the needs of dealers and distributors across North America, ensuring customers have access to high-quality solutions for their waterfront activities.
DecoArt is a manufacturer, marketer and supplier of acrylic paints and craft supplies.
Manufacturer and designer of aluminum fences intended for residential and commercial applications. The company offers cantilevers, estate, ornamental gates, railings, louvers and other related outdoor products, thereby catering to clients with durable and low-maintenance doors.
Relievant Medsystems, Inc. is a medical device company focused on addressing chronic axial low back pain through a minimally invasive procedure known as Intracept. This innovative treatment specifically targets the basivertebral nerve, utilizing radio-frequency energy delivered through a small access tube into the vertebral body to ablate the nerve. The procedure is performed under real-time fluoroscopic guidance, ensuring precision and safety. Founded in 2004 and headquartered in Minneapolis, Minnesota, with an additional office in Sunnyvale, California, Relievant aims to provide low-risk therapeutic solutions that significantly improve the quality of life for patients suffering from vertebrogenic low back pain.
Teel Plastics, Inc. is a manufacturer of custom extruded plastic tubing and profiles, specializing in a wide range of applications. The company produces industrial plastic cores, medical tubing, and various plastic profiles for industries such as healthcare, food, automotive, and aerospace. Its product offerings include water softener tubes, IV set tubing, catheter packaging, and appliance profiles, among others. Teel Plastics also engages in the design and production of engineered components through extrusion and injection molding. Founded in 1951 and based in Baraboo, Wisconsin, the company was formerly known as Insemikit Company, Inc. before rebranding in 1958. Teel Plastics is committed to delivering high-quality products that meet the specific needs of its diverse client base, while also focusing on sustainable practices and workplace safety.
SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for treating chronic inflammatory diseases, including rheumatoid arthritis and Crohn's Disease. The company leverages the Inflammatory Reflex, a natural mechanism that allows the central nervous system to regulate the immune system, which has been extensively studied and documented in scientific literature. SetPoint's proprietary microregulator aims to enhance this reflex through vagus nerve stimulation, offering an alternative treatment option that provides systemic anti-inflammatory effects. The devices are designed to supplement the body's natural responses and are expected to deliver comparable anti-inflammatory potency to leading medications, while potentially offering improved safety and lower costs. Currently, SetPoint is conducting human trials for its technology at multiple centers in Europe.
Private Equity Round in 2019
Garmat USA, LLC specializes in the design and manufacture of paint booths and finishing solutions tailored for large vehicles such as buses, RVs, and commercial trucks, as well as for automotive collision repair, marine, aviation, and industrial markets. Established in 1988 and headquartered in Englewood, Colorado, the company offers a range of products including downdraft paint booths, modified paint booths, closed-top open-front booths, and mixing stations. Garmat USA caters to national multi-site operators and independent repair shops through a comprehensive distributor network, enabling clients to improve productivity while managing operating costs effectively.
Garmat USA, LLC specializes in the design and manufacture of paint booths and finishing solutions tailored for large vehicles such as buses, RVs, and commercial trucks, as well as for automotive collision repair, marine, aviation, and industrial markets. Established in 1988 and headquartered in Englewood, Colorado, the company offers a range of products including downdraft paint booths, modified paint booths, closed-top open-front booths, and mixing stations. Garmat USA caters to national multi-site operators and independent repair shops through a comprehensive distributor network, enabling clients to improve productivity while managing operating costs effectively.
Cantrell Machine Company, Inc. is a manufacturer specializing in equipment and systems for the poultry processing industry. Established in 1972 and based in Gainesville, Georgia, the company has developed a strong reputation for designing and delivering high-quality products tailored to the needs of poultry processors. Its product line includes evisceration and picking equipment, second processing equipment, wing segmenters, vacuum systems, and spare parts. As a subsidiary of Bettcher Industries, Cantrell serves a diverse clientele, supplying equipment to leading poultry processors and contributing to the efficiency and effectiveness of their operations.
Nuvaira, Inc. is a medical device company focused on developing innovative treatments for obstructive lung diseases, particularly chronic obstructive pulmonary disease (COPD). The company has created a novel, catheter-based Lung Denervation System designed to address airway nerve hyperactivity, a common issue in patients with COPD and asthma. This minimally invasive procedure targets the parasympathetic nerves of the lungs, aiming to enhance lung function, improve exercise capacity, and elevate the quality of life for affected individuals. Founded in 2008 and headquartered in Minneapolis, Minnesota, Nuvaira was previously known as Holaira, Inc. before rebranding in June 2017.
NuoDB’s distributed SQL database for cloud applications helps customers get applications to market faster and reduce their total cost of ownership. Software vendors and e-commerce companies rely on NuoDB to obtain the combination of scale-out simplicity, elasticity, and continuous availability that cloud applications require, with the transactional consistency and durability that databases of record demand.
As a result, customers can capitalize on modern technologies such as cloud computing and containerization to ensure their applications are ready for today’s evolving expectations, as well as any future requirements.
NuoDB is headquartered in Cambridge, Massachusetts, USA, with offices in Dublin, London, and Sofia.
Vapotherm, Inc. is a medical technology company based in Exeter, New Hampshire, specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat respiratory distress in patients of all ages. The company offers a range of Precision Flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through small-bore nasal interfaces. Additionally, Vapotherm provides various companion products such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air supply, and specialized adaptors and cannulas to enhance treatment delivery. The company also produces disposable patient circuits for aerosol nebulization and Oxygen Assist Modules to help maintain target oxygen levels. Vapotherm primarily sells its products to hospitals in the United States and through distributors in select international markets. Founded in 1993, Vapotherm aims to improve clinical outcomes and enhance the quality of life for patients.
Olympic Ophthalmics is a medical device company based in Issaquah, Washington, founded in 2017 by Michael Gertner. The company specializes in developing innovative treatments for dry eye disease (DED) by creating devices that stimulate the trigeminal parasympathetic pathway. This stimulation activates the glands responsible for tear film production, allowing healthcare providers to effectively address the signs and symptoms of chronic dry eyes in patients.
Private Equity Round in 2017
Bettcher Industries is an ISO 9001-certified, vertically integrated manufacturing corporation with a worldwide customer base. The company is a leading developer and maker of innovative equipment for food processing, foodservice, industrial, medical and other operations. Established in 1944, Bettcher Industries brings more than seven decades of successful innovation to the market.
SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for treating chronic inflammatory diseases, including rheumatoid arthritis and Crohn's Disease. The company leverages the Inflammatory Reflex, a natural mechanism that allows the central nervous system to regulate the immune system, which has been extensively studied and documented in scientific literature. SetPoint's proprietary microregulator aims to enhance this reflex through vagus nerve stimulation, offering an alternative treatment option that provides systemic anti-inflammatory effects. The devices are designed to supplement the body's natural responses and are expected to deliver comparable anti-inflammatory potency to leading medications, while potentially offering improved safety and lower costs. Currently, SetPoint is conducting human trials for its technology at multiple centers in Europe.
Safe Fuel Systems is a specialized FAA/EASA repair facility that focuses on the testing, repair, overhaul, and modification of fuel systems, hydraulics, and related accessories for both domestic and international aircraft operators, including military aircraft. The company offers round-the-clock support to ensure timely service delivery, helping clients address their repair needs efficiently and cost-effectively through streamlined management and operational practices.
Big Switch Networks Inc. specializes in data center networking technologies, catering to a global audience with solutions that enhance operational efficiency and business agility. Founded in 2010 and headquartered in Santa Clara, California, the company offers two primary products: Big Monitoring Fabric and Big Cloud Fabric. Big Monitoring Fabric functions as a network packet broker, enabling security chains for inline traffic and providing comprehensive visibility across the organization's entire network. Big Cloud Fabric employs open networking and software-defined networking technologies, supporting various environments such as VMware, OpenStack, and network function virtualization. The company's solutions facilitate improved visibility and security in multi-cloud and on-premises enterprise settings. Additionally, Big Switch Networks has formed strategic partnerships with major industry players, contributing to several open source communities to drive innovation in cloud-first networking.
Private Equity Round in 2017
DreamLine is a prominent manufacturer and distributor of high-quality bathroom fixtures and accessories, located in Warminster, Pennsylvania. The company specializes in shower doors, tub doors, shower enclosures, and acrylic shower bases, allowing customers to customize their shower fittings according to their preferences. Known for its commitment to smart and visionary design, DreamLine offers affordable luxury solutions aimed at enhancing the bath and shower experience. The company has received international recognition for its wide range of both standard and custom shower door solutions, characterized by modern aesthetics and impressive value. With a focus on customer satisfaction and exceptional quality, DreamLine strives for excellence in its products and services, positioning itself as a key player in the bathroom marketplace.
Vapotherm, Inc. is a medical technology company based in Exeter, New Hampshire, specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat respiratory distress in patients of all ages. The company offers a range of Precision Flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through small-bore nasal interfaces. Additionally, Vapotherm provides various companion products such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air supply, and specialized adaptors and cannulas to enhance treatment delivery. The company also produces disposable patient circuits for aerosol nebulization and Oxygen Assist Modules to help maintain target oxygen levels. Vapotherm primarily sells its products to hospitals in the United States and through distributors in select international markets. Founded in 1993, Vapotherm aims to improve clinical outcomes and enhance the quality of life for patients.
Moximed, Inc. is focused on developing joint-preserving solutions for patients suffering from knee osteoarthritis. The company's primary product, the Atlas System, functions as an implantable joint unloader, similar to a shock absorber, specifically targeting individuals experiencing pain in the medial compartment of the knee. This innovative approach aims to alleviate joint pain, reduce dynamic load, and potentially delay the necessity for more invasive surgical interventions. Moximed seeks to enhance the standard of care for osteoarthritis patients, helping them maintain an active lifestyle while serving both patients and medical professionals globally. Established in 2006 and headquartered in Hayward, California, Moximed was previously known as ExploraMed NC4, Inc.
Relievant Medsystems, Inc. is a medical device company focused on addressing chronic axial low back pain through a minimally invasive procedure known as Intracept. This innovative treatment specifically targets the basivertebral nerve, utilizing radio-frequency energy delivered through a small access tube into the vertebral body to ablate the nerve. The procedure is performed under real-time fluoroscopic guidance, ensuring precision and safety. Founded in 2004 and headquartered in Minneapolis, Minnesota, with an additional office in Sunnyvale, California, Relievant aims to provide low-risk therapeutic solutions that significantly improve the quality of life for patients suffering from vertebrogenic low back pain.
Miramar Labs, founded in 2006 and based in Sunnyvale, California, specializes in developing medical devices for aesthetic applications. The company's primary product, the miraDry System, offers a non-invasive solution for adults suffering from primary axillary hyperhidrosis, which is excessive sweating in the underarm area. This innovative system employs microwave energy to selectively target and permanently eliminate sweat and odor glands, providing a long-lasting, non-surgical treatment option that enhances the confidence and quality of life for its users. The miraDry System is specifically designed for underarm treatment and is not applicable for hyperhidrosis in other areas of the body, such as the hands and feet.
Second Genome’s mission is to transform lives with medicines developed through innovative microbiome science. Second Genome has built a novel platform for microbiome drug discovery. Second Genome has completed more than 400 microbiome studies, analyzing more than 75,000 samples, for internal R&D, as well as for external partners across government, academia, pharmaceutical, nutrition and industrial companies. The team leverages its microbiome analysis platform with its partners’ specific expertise to generate insightful findings that can accelerate research programs by elucidating the role of the microbiome in human health conditions, agriculture, animal health and other industries. The company has established a pipeline of therapeutic products for the treatment of inflammation and metabolic diseases.
NuoDB’s distributed SQL database for cloud applications helps customers get applications to market faster and reduce their total cost of ownership. Software vendors and e-commerce companies rely on NuoDB to obtain the combination of scale-out simplicity, elasticity, and continuous availability that cloud applications require, with the transactional consistency and durability that databases of record demand.
As a result, customers can capitalize on modern technologies such as cloud computing and containerization to ensure their applications are ready for today’s evolving expectations, as well as any future requirements.
NuoDB is headquartered in Cambridge, Massachusetts, USA, with offices in Dublin, London, and Sofia.
Big Switch Networks Inc. specializes in data center networking technologies, catering to a global audience with solutions that enhance operational efficiency and business agility. Founded in 2010 and headquartered in Santa Clara, California, the company offers two primary products: Big Monitoring Fabric and Big Cloud Fabric. Big Monitoring Fabric functions as a network packet broker, enabling security chains for inline traffic and providing comprehensive visibility across the organization's entire network. Big Cloud Fabric employs open networking and software-defined networking technologies, supporting various environments such as VMware, OpenStack, and network function virtualization. The company's solutions facilitate improved visibility and security in multi-cloud and on-premises enterprise settings. Additionally, Big Switch Networks has formed strategic partnerships with major industry players, contributing to several open source communities to drive innovation in cloud-first networking.
Vapotherm, Inc. is a medical technology company based in Exeter, New Hampshire, specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat respiratory distress in patients of all ages. The company offers a range of Precision Flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through small-bore nasal interfaces. Additionally, Vapotherm provides various companion products such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air supply, and specialized adaptors and cannulas to enhance treatment delivery. The company also produces disposable patient circuits for aerosol nebulization and Oxygen Assist Modules to help maintain target oxygen levels. Vapotherm primarily sells its products to hospitals in the United States and through distributors in select international markets. Founded in 1993, Vapotherm aims to improve clinical outcomes and enhance the quality of life for patients.
Elcelyx was founded in 2010 with venture capital backing based on Gut Sensory Modulation (GSM) technology. Elcelyx’s proprietary, first-in-class Gut Sensory Modulators are delivered directly to the lower gut where they act on molecular targets to elicit physiological and pharmacological effects. The Elcelyx proprietary product candidate, NewMet for Type 2 diabetes is entering Phase 2b development and is a blockbuster opportunity designed to address the unmet needs in the oral anti-diabetic market. Elcelyx is led by an experienced management team and Board of Directors with track records of success in drug development and commercialization. Premier investors along with seasoned scientists and clinicians support the team. In September 2013, Elcelyx announced the formation of NaZura BioHealth Inc, a separate company established to focus on the development on non-NewMet assets. Elcelyx is headquartered in San Diego, California.
Adara, the global leader in permissioned data and verified identity, combines the power of global data consortiums to inform its 1 billion digital identities with over 22 billion data elements across 130 countries and serving Global 2,000 customers. Whether informing digital marketing, programmatic advertising, search, identity and verification, or stopping fraud, Adara provides you with more customers, less friction, and better outcomes. For more information, visit us at www.ADARA.com.
SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for treating chronic inflammatory diseases, including rheumatoid arthritis and Crohn's Disease. The company leverages the Inflammatory Reflex, a natural mechanism that allows the central nervous system to regulate the immune system, which has been extensively studied and documented in scientific literature. SetPoint's proprietary microregulator aims to enhance this reflex through vagus nerve stimulation, offering an alternative treatment option that provides systemic anti-inflammatory effects. The devices are designed to supplement the body's natural responses and are expected to deliver comparable anti-inflammatory potency to leading medications, while potentially offering improved safety and lower costs. Currently, SetPoint is conducting human trials for its technology at multiple centers in Europe.
Kona Medical, Inc. is a medical technology company based in Issaquah, Washington, founded in 2009 by Dr. Michael Gertner. The company specializes in developing a non-invasive ultrasound-based therapy system aimed at treating hypertension and related disorders. Its primary product, Surround Sound, is a hypertension therapy system that employs ultrasound imaging to precisely deliver focused ultrasound energy for renal denervation. This innovative approach targets the nerves associated with kidney function, offering a less invasive alternative for patients suffering from drug-resistant hypertension. By leveraging advancements in therapeutic focused ultrasound, Kona Medical seeks to improve treatment efficacy and reduce the health risks associated with high blood pressure.
Principia Biopharma Inc. is a late-stage biopharmaceutical company based in South San Francisco, California, focused on developing innovative therapies for immune-mediated diseases. The company's lead candidate, rilzabrutinib, is an inhibitor currently undergoing Phase III clinical trials for pemphigus and pemphigus foliaceus, as well as Phase 1/2 and Phase 2 trials for immune thrombocytopenia and IgG4-related disease, respectively. Additionally, Principia is advancing PRN2246/SAR442168, aimed at treating multiple sclerosis and other central nervous system disorders, which is in Phase II trials. Another candidate, PRN473, is in Phase I trials for various immune-mediated diseases. Principia Biopharma collaborates with Genzyme Corporation to explore treatments for relapsing and progressive multiple sclerosis, enhancing its commitment to addressing significant unmet medical needs in immunology and oncology. Established in 2008, the company operates as a subsidiary of Sanofi.
Ra Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, focused on developing therapeutics for diseases linked to the complement system's excessive activation. Utilizing a proprietary peptide chemistry platform, the company creates synthetic macrocyclic peptides that possess the specificity of antibodies and the advantageous properties of small molecules. Its primary product candidate, Zilucoplan, is an injectable treatment that has completed Phase II clinical trials for generalized myasthenia gravis and paroxysmal nocturnal hemoglobinuria, as well as a Phase Ib trial for patients with renal impairment. Ra Pharmaceuticals is also exploring pre-clinical programs targeting various complement factors for conditions such as C3 glomerulonephritis and autoimmune diseases. Additionally, the company has a collaboration with Merck & Co. to identify orally available cyclic peptides for cardiovascular targets. Founded in 2008, Ra Pharmaceuticals operates as a subsidiary of UCB SA.
Vapotherm, Inc. is a medical technology company based in Exeter, New Hampshire, specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat respiratory distress in patients of all ages. The company offers a range of Precision Flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through small-bore nasal interfaces. Additionally, Vapotherm provides various companion products such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air supply, and specialized adaptors and cannulas to enhance treatment delivery. The company also produces disposable patient circuits for aerosol nebulization and Oxygen Assist Modules to help maintain target oxygen levels. Vapotherm primarily sells its products to hospitals in the United States and through distributors in select international markets. Founded in 1993, Vapotherm aims to improve clinical outcomes and enhance the quality of life for patients.
Galleon Pharmaceuticals, Inc., a pharmaceutical company, discovers, develops, and markets treatments for sleep apnea and related breathing control disorders. It offers GAL-021, a small molecule for intravenous administration designed to support respiratory drive in surgical and critical care patients and patients with sleep apnea; GLN- 21,160, an oral development candidate for sleep apnea; and GAL-044, a small molecule used as a preventative medicine for surgical pain. The company was founded in 2003 and is based in Horsham, Pennsylvania.
MuleSoft, Inc. is a provider of the Anypoint Platform, a cloud-based application integration solution that enables organizations to connect their applications, data, and devices. Founded in 2006 and headquartered in San Francisco, California, MuleSoft facilitates the creation of application networks through its flexible platform, which utilizes APIs to enable seamless communication between various systems and applications, whether cloud-based or on-premises. The platform allows customers to build reusable components, simplifying the integration process and promoting business agility. MuleSoft has established a strategic alliance with IQVIA and operates as a subsidiary of Salesforce.
Moximed, Inc. is focused on developing joint-preserving solutions for patients suffering from knee osteoarthritis. The company's primary product, the Atlas System, functions as an implantable joint unloader, similar to a shock absorber, specifically targeting individuals experiencing pain in the medial compartment of the knee. This innovative approach aims to alleviate joint pain, reduce dynamic load, and potentially delay the necessity for more invasive surgical interventions. Moximed seeks to enhance the standard of care for osteoarthritis patients, helping them maintain an active lifestyle while serving both patients and medical professionals globally. Established in 2006 and headquartered in Hayward, California, Moximed was previously known as ExploraMed NC4, Inc.
Twelve manufactures medical devices. It was formerly known as Foundry Newco XII, Inc. The company was incorporated in 2009 and is based in Menlo Park, California.
NuoDB’s distributed SQL database for cloud applications helps customers get applications to market faster and reduce their total cost of ownership. Software vendors and e-commerce companies rely on NuoDB to obtain the combination of scale-out simplicity, elasticity, and continuous availability that cloud applications require, with the transactional consistency and durability that databases of record demand.
As a result, customers can capitalize on modern technologies such as cloud computing and containerization to ensure their applications are ready for today’s evolving expectations, as well as any future requirements.
NuoDB is headquartered in Cambridge, Massachusetts, USA, with offices in Dublin, London, and Sofia.
dlhBOWLES manufactures and markets plastic air and fluid handling assemblies, tubing, hoses, and profile extrusions. It offers injection molded thermoplastic parts, design and engineering services, precision injection molding, washer system tubing assemblies, air and fluid management, extruded thermoplastic tubes and profiles, rapid prototyping, and lab testing and design of experiments for process. dlhBOWLES was formerly known as DLH Industries, Inc. and changed its name to dlhBOWLES in July 2015. The company was founded in 1975 and is based in Canton, Ohio. dlhBOWLES operates as a subsidiary of Bowles Fluidics Corporation.
Sunlight Aerospace is a technology development company based in South Plainfield, New Jersey, specializing in advanced solar unmanned aerial vehicles (UAVs). The company focuses on creating fleets of solar UAVs, known as Sunfleets, which feature innovative airframe designs, lightweight photovoltaic systems, and advanced formation flight control. These UAVs are engineered for high-altitude, long-endurance missions, serving as platforms for new airborne communication networks that provide wireless broadband and internet services. In addition to UAV development, Sunlight Aerospace also offers communication networks and custom firmware and software for managing flight control, power management, and communications. Their solar UAVs have diverse applications, including wireless communications, precision agriculture, land surveys, and monitoring for wildfires and wildlife, as well as border patrol operations. Founded in 2007, Sunlight Aerospace is dedicated to advancing the field of airborne wireless communication technology.
Socrata is the market leader in making existing government data discoverable, usable, and actionable for government workers and the people they serve. Socrata provides a data-as-a-service data platform and cloud applications exclusively for city, county, state, and federal government organizations.
Socrata delivers unprecedented, data-driven innovation and cost-savings by bringing together disparate systems and leveraging the cloud to dramatically enhance the effectiveness of government programs, to improve quality of life for residents, positively impact local economies, and achieve excellence in government operations. Socrata solutions are designed and developed to meet strict government standards. The technology is optimized on the Amazon Web Services (AWS) Public Sector cloud and delivered using the exclusive Socrata Blueprint Methodology. Socrata has earned Federal Risk and Authorization Management Program (FedRAMP) Authority to Operate (ATO).
Miramar Labs, founded in 2006 and based in Sunnyvale, California, specializes in developing medical devices for aesthetic applications. The company's primary product, the miraDry System, offers a non-invasive solution for adults suffering from primary axillary hyperhidrosis, which is excessive sweating in the underarm area. This innovative system employs microwave energy to selectively target and permanently eliminate sweat and odor glands, providing a long-lasting, non-surgical treatment option that enhances the confidence and quality of life for its users. The miraDry System is specifically designed for underarm treatment and is not applicable for hyperhidrosis in other areas of the body, such as the hands and feet.
Ivantis Inc. is dedicated to developing innovative treatments for primary open angle glaucoma, a condition affecting over 60 million people globally. The company has created an intracanalicular scaffold or implantable device designed to alleviate high intraocular pressure in patients, offering a less invasive and more effective therapeutic option. Founded in 2007 and based in Irvine, California, Ivantis also provides a Session Persistence Server, which safeguards telnet task workers against data loss due to network issues and ensures terminal emulation users maintain productivity across various devices and operating systems. As Ivantis advances its glaucoma treatment solutions, it aims to expand its focus to other debilitating ophthalmic diseases. The company primarily serves ophthalmology specialists in the United States, providing its solutions for use in clinical trials.
Principia Biopharma Inc. is a late-stage biopharmaceutical company based in South San Francisco, California, focused on developing innovative therapies for immune-mediated diseases. The company's lead candidate, rilzabrutinib, is an inhibitor currently undergoing Phase III clinical trials for pemphigus and pemphigus foliaceus, as well as Phase 1/2 and Phase 2 trials for immune thrombocytopenia and IgG4-related disease, respectively. Additionally, Principia is advancing PRN2246/SAR442168, aimed at treating multiple sclerosis and other central nervous system disorders, which is in Phase II trials. Another candidate, PRN473, is in Phase I trials for various immune-mediated diseases. Principia Biopharma collaborates with Genzyme Corporation to explore treatments for relapsing and progressive multiple sclerosis, enhancing its commitment to addressing significant unmet medical needs in immunology and oncology. Established in 2008, the company operates as a subsidiary of Sanofi.
ForSight Labs is dedicated to developing innovative ophthalmic technologies aimed at enhancing the sight and quality of life for visually impaired patients. The organization collaborates with entrepreneurs, investors, and clinicians to drive advancements in eye care through the creation and commercialization of high-impact solutions. With millions of individuals in the U.S. suffering from vision impairment and the associated economic burden exceeding $50 billion annually, ForSight Labs addresses a significant public health challenge. Their focus includes developing treatments for conditions such as glaucoma, which can lead to irreversible blindness in adults. By fostering a creative and cooperative environment, ForSight Labs strives to deliver effective solutions to the ophthalmic community and the patients it serves.
ForSight VISION5, founded in 2010 as part of ForSight Labs, specializes in developing innovative drug delivery technologies aimed at treating various eye conditions. The company focuses on creating non-invasive products designed to replace traditional eye drops, offering sustained therapy for significant eye diseases such as glaucoma, dry eye, and allergies. Currently, ForSight VISION5 is in its second Phase 2 clinical study for its lead product, the Helios insert, which represents a significant advancement in ocular treatment options.
Vapotherm, Inc. is a medical technology company based in Exeter, New Hampshire, specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat respiratory distress in patients of all ages. The company offers a range of Precision Flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through small-bore nasal interfaces. Additionally, Vapotherm provides various companion products such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air supply, and specialized adaptors and cannulas to enhance treatment delivery. The company also produces disposable patient circuits for aerosol nebulization and Oxygen Assist Modules to help maintain target oxygen levels. Vapotherm primarily sells its products to hospitals in the United States and through distributors in select international markets. Founded in 1993, Vapotherm aims to improve clinical outcomes and enhance the quality of life for patients.
Nuvaira, Inc. is a medical device company focused on developing innovative treatments for obstructive lung diseases, particularly chronic obstructive pulmonary disease (COPD). The company has created a novel, catheter-based Lung Denervation System designed to address airway nerve hyperactivity, a common issue in patients with COPD and asthma. This minimally invasive procedure targets the parasympathetic nerves of the lungs, aiming to enhance lung function, improve exercise capacity, and elevate the quality of life for affected individuals. Founded in 2008 and headquartered in Minneapolis, Minnesota, Nuvaira was previously known as Holaira, Inc. before rebranding in June 2017.
MuleSoft, Inc. is a provider of the Anypoint Platform, a cloud-based application integration solution that enables organizations to connect their applications, data, and devices. Founded in 2006 and headquartered in San Francisco, California, MuleSoft facilitates the creation of application networks through its flexible platform, which utilizes APIs to enable seamless communication between various systems and applications, whether cloud-based or on-premises. The platform allows customers to build reusable components, simplifying the integration process and promoting business agility. MuleSoft has established a strategic alliance with IQVIA and operates as a subsidiary of Salesforce.
NuoDB’s distributed SQL database for cloud applications helps customers get applications to market faster and reduce their total cost of ownership. Software vendors and e-commerce companies rely on NuoDB to obtain the combination of scale-out simplicity, elasticity, and continuous availability that cloud applications require, with the transactional consistency and durability that databases of record demand.
As a result, customers can capitalize on modern technologies such as cloud computing and containerization to ensure their applications are ready for today’s evolving expectations, as well as any future requirements.
NuoDB is headquartered in Cambridge, Massachusetts, USA, with offices in Dublin, London, and Sofia.
Elcelyx was founded in 2010 with venture capital backing based on Gut Sensory Modulation (GSM) technology. Elcelyx’s proprietary, first-in-class Gut Sensory Modulators are delivered directly to the lower gut where they act on molecular targets to elicit physiological and pharmacological effects. The Elcelyx proprietary product candidate, NewMet for Type 2 diabetes is entering Phase 2b development and is a blockbuster opportunity designed to address the unmet needs in the oral anti-diabetic market. Elcelyx is led by an experienced management team and Board of Directors with track records of success in drug development and commercialization. Premier investors along with seasoned scientists and clinicians support the team. In September 2013, Elcelyx announced the formation of NaZura BioHealth Inc, a separate company established to focus on the development on non-NewMet assets. Elcelyx is headquartered in San Diego, California.
HealthLoop, Inc. operates a software-as-a-service platform that supports medical practices in monitoring patient recovery through ongoing communication and symptom tracking. Founded in 2009 and based in Moffett Field, California, the platform enables healthcare providers to identify patients at risk of decline during the follow-up period. By collecting patient feedback and comparing their recovery status against expected progress, HealthLoop facilitates timely alerts to physicians regarding potential treatment failures, complications, or hospital readmissions. The company primarily serves medical offices across the United States, aiming to enhance patient engagement and improve overall care coordination.
Calithera Biosciences, Inc. is a clinical-stage biopharmaceutical company based in South San Francisco, California, dedicated to discovering and developing small molecule therapeutics for cancer treatment. The company focuses on targeting tumor metabolism and tumor immunology to create innovative anti-cancer drugs. Its lead product candidate, CB-839, is an inhibitor of glutaminase currently undergoing Phase II clinical trials for solid tumors. Additionally, Calithera is developing CB-1158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology indications. The company is also working on other candidates, including CB-280 for cystic fibrosis and CB-708, an inhibitor of CD73. Calithera has established collaborations with major pharmaceutical firms, including Bristol-Myers Squibb and Incyte Corporation, to advance its research and development efforts. Founded in 2010, Calithera aims to address critical challenges in cancer therapy through its specialized drug development pipeline.
PeopleMatter, Inc. is a workforce management platform that specializes in talent management software designed to enhance the performance of service-industry brands. Founded in 2001 and based in Charleston, South Carolina, the company provides solutions tailored for various sectors, including technology, transportation, healthcare, government, biotech, and recreation. PeopleMatter offers a comprehensive hire-to-retire system that simplifies the hiring process for hourly and shift workers, enabling managers to source, screen, and onboard employees more efficiently. By streamlining applicant tracking and onboarding, the platform aims to reduce friction in recruiting and improve overall efficiency, engagement, and customer satisfaction within the service industry. In June 2016, PeopleMatter was acquired by Snagajob.
Practice Fusion, Inc. is a cloud-based electronic health records (EHR) company based in San Francisco, California. Founded in 2005, it provides a practice management software platform that includes features such as charting, scheduling, billing, e-Prescribing, lab integrations, and secure messaging. The platform aims to connect a wide range of stakeholders in the healthcare ecosystem, including medical professionals, patients, labs, billers, imaging centers, and life science partners. Additionally, Practice Fusion offers Practice Fusion Insight, a healthcare database designed for medical professionals. The company serves a diverse clientele, including independent practices, small and large medical groups, community organizations, and non-profits. In 2018, Practice Fusion became a subsidiary of Allscripts Healthcare Solutions, further enhancing its capabilities in the electronic health records space.
Convo provides an enterprise social collaboration platform that enables easy, secure conversations between desk/non-desk workers to accelerate company productivity and engagement. Unlike existing email-focused or chat-centric collaboration platforms, only Convo combines the ease of social networks with rich collaboration capabilities to simplify and optimize work interactions for all employees -- no email required.
Mint Bills is an application designed to help users manage their finances by setting reminders for bill payments. It employs proprietary account aggregation technology to ensure secure payment processing within its mobile applications. The primary service offered by Mint Bills allows users to pay bills and monitor their bank accounts, credit card transactions, investments, and loan balances through a user-friendly interface. The application is available on both iOS and Android platforms, making it accessible to a wide range of users.
SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for treating chronic inflammatory diseases, including rheumatoid arthritis and Crohn's Disease. The company leverages the Inflammatory Reflex, a natural mechanism that allows the central nervous system to regulate the immune system, which has been extensively studied and documented in scientific literature. SetPoint's proprietary microregulator aims to enhance this reflex through vagus nerve stimulation, offering an alternative treatment option that provides systemic anti-inflammatory effects. The devices are designed to supplement the body's natural responses and are expected to deliver comparable anti-inflammatory potency to leading medications, while potentially offering improved safety and lower costs. Currently, SetPoint is conducting human trials for its technology at multiple centers in Europe.
Socrata is the market leader in making existing government data discoverable, usable, and actionable for government workers and the people they serve. Socrata provides a data-as-a-service data platform and cloud applications exclusively for city, county, state, and federal government organizations.
Socrata delivers unprecedented, data-driven innovation and cost-savings by bringing together disparate systems and leveraging the cloud to dramatically enhance the effectiveness of government programs, to improve quality of life for residents, positively impact local economies, and achieve excellence in government operations. Socrata solutions are designed and developed to meet strict government standards. The technology is optimized on the Amazon Web Services (AWS) Public Sector cloud and delivered using the exclusive Socrata Blueprint Methodology. Socrata has earned Federal Risk and Authorization Management Program (FedRAMP) Authority to Operate (ATO).
ForSight Labs is dedicated to developing innovative ophthalmic technologies aimed at enhancing the sight and quality of life for visually impaired patients. The organization collaborates with entrepreneurs, investors, and clinicians to drive advancements in eye care through the creation and commercialization of high-impact solutions. With millions of individuals in the U.S. suffering from vision impairment and the associated economic burden exceeding $50 billion annually, ForSight Labs addresses a significant public health challenge. Their focus includes developing treatments for conditions such as glaucoma, which can lead to irreversible blindness in adults. By fostering a creative and cooperative environment, ForSight Labs strives to deliver effective solutions to the ophthalmic community and the patients it serves.
Automatic's mission is to empower drivers with knowledge about themselves and their cars so they can be safer and drive smarter. Automatic believes that drivers should not have to buy a new car to have a better driving experience, and that the phone in their pocket can bring the future of driving to today's automobiles. Automatic is based in San Francisco, California, but its team comes from every corner of the world. The team obsesses about creating beautiful and well-engineered products that make a real difference in people's lives. Its members are big on ideas, low on ego, and love working together.
Second Genome’s mission is to transform lives with medicines developed through innovative microbiome science. Second Genome has built a novel platform for microbiome drug discovery. Second Genome has completed more than 400 microbiome studies, analyzing more than 75,000 samples, for internal R&D, as well as for external partners across government, academia, pharmaceutical, nutrition and industrial companies. The team leverages its microbiome analysis platform with its partners’ specific expertise to generate insightful findings that can accelerate research programs by elucidating the role of the microbiome in human health conditions, agriculture, animal health and other industries. The company has established a pipeline of therapeutic products for the treatment of inflammation and metabolic diseases.
Scioderm, LLC is a clinical-stage pharmaceutical company based in Durham, North Carolina, specializing in the research, development, and manufacture of drugs for chronic skin diseases, particularly epidermolysis bullosa (EB). Founded in 2012, the company is focused on creating topical therapies to meet significant medical needs in the dermatological field. Its primary investigational product, Zorblisa, is designed to treat the skin blistering and lesions associated with EB, a rare inherited disorder characterized by fragile skin. Zorblisa aims to facilitate the healing of existing skin lesions while reducing the frequency and severity of new lesions. As of September 2015, Scioderm operates as a subsidiary of Amicus Therapeutics, Inc.
Vapotherm, Inc. is a medical technology company based in Exeter, New Hampshire, specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat respiratory distress in patients of all ages. The company offers a range of Precision Flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through small-bore nasal interfaces. Additionally, Vapotherm provides various companion products such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air supply, and specialized adaptors and cannulas to enhance treatment delivery. The company also produces disposable patient circuits for aerosol nebulization and Oxygen Assist Modules to help maintain target oxygen levels. Vapotherm primarily sells its products to hospitals in the United States and through distributors in select international markets. Founded in 1993, Vapotherm aims to improve clinical outcomes and enhance the quality of life for patients.
MuleSoft, Inc. is a provider of the Anypoint Platform, a cloud-based application integration solution that enables organizations to connect their applications, data, and devices. Founded in 2006 and headquartered in San Francisco, California, MuleSoft facilitates the creation of application networks through its flexible platform, which utilizes APIs to enable seamless communication between various systems and applications, whether cloud-based or on-premises. The platform allows customers to build reusable components, simplifying the integration process and promoting business agility. MuleSoft has established a strategic alliance with IQVIA and operates as a subsidiary of Salesforce.
Catalyst Biosciences is a clinical-stage biopharmaceutical company based in South San Francisco, California, specializing in the development of innovative treatments for hemophilia and other rare bleeding disorders. The company focuses on engineered subcutaneous coagulation factors that enhance blood clotting, aiming to improve patient outcomes compared to traditional intravenous treatments. Its key products include Marzeptacog alfa (activated), an advanced coagulation Factor VIIa that has completed Phase II trials for patients with hemophilia A or B with inhibitors, and Dalcinonacog alfa, an engineered Factor IX therapy that has finished Phase IIb clinical trials for hemophilia B. Catalyst is also developing early-stage gene therapy constructs and long-acting anti-C3 proteases for conditions such as dry age-related macular degeneration (AMD). The company collaborates with Mosaic Biosciences to create anti-complement factor 3 products for retinal diseases and has a partnership with Biogen for the commercialization of pegylated anti-C3 protease therapies. Founded in 2002, Catalyst Biosciences is dedicated to establishing protease therapeutics as a significant new therapeutic platform.
PeopleMatter, Inc. is a workforce management platform that specializes in talent management software designed to enhance the performance of service-industry brands. Founded in 2001 and based in Charleston, South Carolina, the company provides solutions tailored for various sectors, including technology, transportation, healthcare, government, biotech, and recreation. PeopleMatter offers a comprehensive hire-to-retire system that simplifies the hiring process for hourly and shift workers, enabling managers to source, screen, and onboard employees more efficiently. By streamlining applicant tracking and onboarding, the platform aims to reduce friction in recruiting and improve overall efficiency, engagement, and customer satisfaction within the service industry. In June 2016, PeopleMatter was acquired by Snagajob.
Adara, the global leader in permissioned data and verified identity, combines the power of global data consortiums to inform its 1 billion digital identities with over 22 billion data elements across 130 countries and serving Global 2,000 customers. Whether informing digital marketing, programmatic advertising, search, identity and verification, or stopping fraud, Adara provides you with more customers, less friction, and better outcomes. For more information, visit us at www.ADARA.com.
Nuvaira, Inc. is a medical device company focused on developing innovative treatments for obstructive lung diseases, particularly chronic obstructive pulmonary disease (COPD). The company has created a novel, catheter-based Lung Denervation System designed to address airway nerve hyperactivity, a common issue in patients with COPD and asthma. This minimally invasive procedure targets the parasympathetic nerves of the lungs, aiming to enhance lung function, improve exercise capacity, and elevate the quality of life for affected individuals. Founded in 2008 and headquartered in Minneapolis, Minnesota, Nuvaira was previously known as Holaira, Inc. before rebranding in June 2017.
Private Equity Round in 2013
OptiScan Biomedical Corporation develops glucose monitoring systems for the intensive care unit (ICU)/CCU. It offers OptiScanner, an automated, bedside glucose monitoring system to assist healthcare providers manage the glucose level of critically ill patients. The company’s OptiScanner provides serial blood glucose measurements for a range of glucose concentrations. OptiScan Biomedical Corporation was founded in 1994 and is based in Hayward, California.
R2 Semiconductor, Inc. is a power management company based in Sunnyvale, California, founded in 2008. The company specializes in low-voltage transistors and has developed innovative technologies aimed at optimizing power management. Its product offerings include FasTrack, designed for envelope tracking, and FastLane, which enhances power management for multi-core application processors and digital System on Chips (SoCs). R2 Semiconductor operates as a fabless semiconductor firm, leveraging the expertise of its experienced industry veterans to advance a new class of power management solutions.
Now known as [SalesforceIQ](https://www.crunchbase.com/organization/salesforceiq), RelateIQ, a salesforce.com company, has re-thought customer relationship management from the ground up, building the world's first Relationship Intelligence platform. It automatically captures data on your most important sales prospects, making it easy to collaborate with your teammates to close deals faster. The platform works everywhere you work, whether it's on a mobile app in your pocket or in your email inbox through a browser extension, and advanced data science capabilities mean RelateIQ will provide the insights you need before you even realize you need them. RelateIQ helps our customers drive more revenue and save hours of time, all while making their jobs less work. For more information on how RelateIQ is changing the way the world works, please connect with us on Facebook, LinkedIn, or Twitter.
Calithera Biosciences, Inc. is a clinical-stage biopharmaceutical company based in South San Francisco, California, dedicated to discovering and developing small molecule therapeutics for cancer treatment. The company focuses on targeting tumor metabolism and tumor immunology to create innovative anti-cancer drugs. Its lead product candidate, CB-839, is an inhibitor of glutaminase currently undergoing Phase II clinical trials for solid tumors. Additionally, Calithera is developing CB-1158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology indications. The company is also working on other candidates, including CB-280 for cystic fibrosis and CB-708, an inhibitor of CD73. Calithera has established collaborations with major pharmaceutical firms, including Bristol-Myers Squibb and Incyte Corporation, to advance its research and development efforts. Founded in 2010, Calithera aims to address critical challenges in cancer therapy through its specialized drug development pipeline.
Kona Medical, Inc. is a medical technology company based in Issaquah, Washington, founded in 2009 by Dr. Michael Gertner. The company specializes in developing a non-invasive ultrasound-based therapy system aimed at treating hypertension and related disorders. Its primary product, Surround Sound, is a hypertension therapy system that employs ultrasound imaging to precisely deliver focused ultrasound energy for renal denervation. This innovative approach targets the nerves associated with kidney function, offering a less invasive alternative for patients suffering from drug-resistant hypertension. By leveraging advancements in therapeutic focused ultrasound, Kona Medical seeks to improve treatment efficacy and reduce the health risks associated with high blood pressure.
Big Switch Networks Inc. specializes in data center networking technologies, catering to a global audience with solutions that enhance operational efficiency and business agility. Founded in 2010 and headquartered in Santa Clara, California, the company offers two primary products: Big Monitoring Fabric and Big Cloud Fabric. Big Monitoring Fabric functions as a network packet broker, enabling security chains for inline traffic and providing comprehensive visibility across the organization's entire network. Big Cloud Fabric employs open networking and software-defined networking technologies, supporting various environments such as VMware, OpenStack, and network function virtualization. The company's solutions facilitate improved visibility and security in multi-cloud and on-premises enterprise settings. Additionally, Big Switch Networks has formed strategic partnerships with major industry players, contributing to several open source communities to drive innovation in cloud-first networking.
Principia Biopharma Inc. is a late-stage biopharmaceutical company based in South San Francisco, California, focused on developing innovative therapies for immune-mediated diseases. The company's lead candidate, rilzabrutinib, is an inhibitor currently undergoing Phase III clinical trials for pemphigus and pemphigus foliaceus, as well as Phase 1/2 and Phase 2 trials for immune thrombocytopenia and IgG4-related disease, respectively. Additionally, Principia is advancing PRN2246/SAR442168, aimed at treating multiple sclerosis and other central nervous system disorders, which is in Phase II trials. Another candidate, PRN473, is in Phase I trials for various immune-mediated diseases. Principia Biopharma collaborates with Genzyme Corporation to explore treatments for relapsing and progressive multiple sclerosis, enhancing its commitment to addressing significant unmet medical needs in immunology and oncology. Established in 2008, the company operates as a subsidiary of Sanofi.
Promedior, Inc. is a clinical-stage biotechnology company based in Lexington, Massachusetts, focused on developing therapeutics for rare fibrotic diseases, such as idiopathic pulmonary fibrosis and myelofibrosis, as well as retinal fibrovascular diseases like age-related macular degeneration and diabetic retinopathy. The company has created a drug discovery platform that targets monocyte-derived cell populations involved in fibrotic, inflammatory, and autoimmune diseases. By addressing the source of abnormal immune responses, Promedior aims to promote tissue healing while minimizing systemic side effects associated with existing therapies. Its main products include PRM-151, a recombinant form of human pentaxin-2 protein for intravenous injection, and PRM-167, designed for intravitreal delivery. Promedior was previously known as Fibrotix, Inc. and has been a subsidiary of Roche Holding AG since February 2020.
Catalyst Biosciences is a clinical-stage biopharmaceutical company based in South San Francisco, California, specializing in the development of innovative treatments for hemophilia and other rare bleeding disorders. The company focuses on engineered subcutaneous coagulation factors that enhance blood clotting, aiming to improve patient outcomes compared to traditional intravenous treatments. Its key products include Marzeptacog alfa (activated), an advanced coagulation Factor VIIa that has completed Phase II trials for patients with hemophilia A or B with inhibitors, and Dalcinonacog alfa, an engineered Factor IX therapy that has finished Phase IIb clinical trials for hemophilia B. Catalyst is also developing early-stage gene therapy constructs and long-acting anti-C3 proteases for conditions such as dry age-related macular degeneration (AMD). The company collaborates with Mosaic Biosciences to create anti-complement factor 3 products for retinal diseases and has a partnership with Biogen for the commercialization of pegylated anti-C3 protease therapies. Founded in 2002, Catalyst Biosciences is dedicated to establishing protease therapeutics as a significant new therapeutic platform.
Nuvaira, Inc. is a medical device company focused on developing innovative treatments for obstructive lung diseases, particularly chronic obstructive pulmonary disease (COPD). The company has created a novel, catheter-based Lung Denervation System designed to address airway nerve hyperactivity, a common issue in patients with COPD and asthma. This minimally invasive procedure targets the parasympathetic nerves of the lungs, aiming to enhance lung function, improve exercise capacity, and elevate the quality of life for affected individuals. Founded in 2008 and headquartered in Minneapolis, Minnesota, Nuvaira was previously known as Holaira, Inc. before rebranding in June 2017.
Doximity is a digital platform that serves as the largest professional medical network in the United States, connecting over 70 percent of U.S. physicians. Founded in 2011 and based in San Francisco, Doximity provides a suite of tools designed specifically for medical professionals, including physicians, nurse practitioners, physician assistants, and registered nurses. The platform facilitates secure communication among healthcare providers, enabling them to collaborate on patient care, conduct virtual visits, and stay informed about the latest medical news and research. Additionally, Doximity offers resources to help medical professionals manage their careers effectively.
ForSight VISION5, founded in 2010 as part of ForSight Labs, specializes in developing innovative drug delivery technologies aimed at treating various eye conditions. The company focuses on creating non-invasive products designed to replace traditional eye drops, offering sustained therapy for significant eye diseases such as glaucoma, dry eye, and allergies. Currently, ForSight VISION5 is in its second Phase 2 clinical study for its lead product, the Helios insert, which represents a significant advancement in ocular treatment options.
Elcelyx was founded in 2010 with venture capital backing based on Gut Sensory Modulation (GSM) technology. Elcelyx’s proprietary, first-in-class Gut Sensory Modulators are delivered directly to the lower gut where they act on molecular targets to elicit physiological and pharmacological effects. The Elcelyx proprietary product candidate, NewMet for Type 2 diabetes is entering Phase 2b development and is a blockbuster opportunity designed to address the unmet needs in the oral anti-diabetic market. Elcelyx is led by an experienced management team and Board of Directors with track records of success in drug development and commercialization. Premier investors along with seasoned scientists and clinicians support the team. In September 2013, Elcelyx announced the formation of NaZura BioHealth Inc, a separate company established to focus on the development on non-NewMet assets. Elcelyx is headquartered in San Diego, California.
Sonatype, Inc. is a provider of software supply chain automation solutions aimed at enhancing software innovation, quality, and security. Established in 2008 and based in Fulton, Maryland, with additional offices in McLean, Virginia; London, United Kingdom; and Sydney, Australia, the company offers a range of products including Nexus Lifecycle, which manages the flow of software components, and Nexus Firewall, designed to prevent risky components from entering the supply chain. Its Nexus Auditor continuously monitors applications in production, while Nexus Repository organizes, stores, and distributes software components. Sonatype also supports the open-source community, having been a core contributor to Apache Maven and facilitating access to the largest repository of open source components. The company serves various industries, including finance, government, technology, insurance, healthcare, and manufacturing, and maintains strategic partnerships to enhance its offerings.
NuoDB’s distributed SQL database for cloud applications helps customers get applications to market faster and reduce their total cost of ownership. Software vendors and e-commerce companies rely on NuoDB to obtain the combination of scale-out simplicity, elasticity, and continuous availability that cloud applications require, with the transactional consistency and durability that databases of record demand.
As a result, customers can capitalize on modern technologies such as cloud computing and containerization to ensure their applications are ready for today’s evolving expectations, as well as any future requirements.
NuoDB is headquartered in Cambridge, Massachusetts, USA, with offices in Dublin, London, and Sofia.
Pickwick & Weller, located in Los Angeles, specializes in designing and selling boutique t-shirts. The company focuses on creating modern workwear with sharp designs and a meticulous fit, emphasizing the development of beautifully crafted basics. With a commitment to quality, Pickwick & Weller aims to redefine contemporary apparel, one t-shirt at a time.
Rhythm NewMedia specializes in connecting brand advertisers with engaged mobile audiences through the sale and delivery of video, rich media, and immersive advertising formats. The company collaborates with over 50 premium media partners, including notable names such as NBC Universal, CBS, and Sony, to offer advertising within high-quality content across a diverse portfolio exceeding 200 properties. In 2011, Rhythm successfully facilitated campaigns for more than 200 top brand advertisers, including P&G, Unilever, Disney, and General Motors, achieving significant engagement results. The company is backed by prominent investors such as Lightspeed Venture Partners and Morgenthaler Ventures, supporting its mission to enhance brand advertising effectiveness in the mobile landscape.
Practice Fusion, Inc. is a cloud-based electronic health records (EHR) company based in San Francisco, California. Founded in 2005, it provides a practice management software platform that includes features such as charting, scheduling, billing, e-Prescribing, lab integrations, and secure messaging. The platform aims to connect a wide range of stakeholders in the healthcare ecosystem, including medical professionals, patients, labs, billers, imaging centers, and life science partners. Additionally, Practice Fusion offers Practice Fusion Insight, a healthcare database designed for medical professionals. The company serves a diverse clientele, including independent practices, small and large medical groups, community organizations, and non-profits. In 2018, Practice Fusion became a subsidiary of Allscripts Healthcare Solutions, further enhancing its capabilities in the electronic health records space.
Twelve
Venture Round in 2012
Twelve manufactures medical devices. It was formerly known as Foundry Newco XII, Inc. The company was incorporated in 2009 and is based in Menlo Park, California.
Hownd, formerly known as LocBox, provides local businesses with effective marketing solutions designed to generate repeat customers and increase foot traffic. By offering a comprehensive Integrated Marketing product, Hownd enables businesses to manage campaigns across various channels—including email, social media, and text messaging—through a single dashboard. This approach helps local establishments, often lacking the expertise and resources for effective marketing, connect with their best customers in a timely and relevant manner. Hownd focuses on industries such as entertainment, health and beauty, and food and beverage, allowing these businesses to move away from generic marketing strategies that yield minimal results. With a growing client base that includes hundreds of businesses and franchises across the U.S., Hownd effectively manages millions of emails and social media interactions, empowering local owners to drive revenue and enhance customer engagement.
Kona Medical, Inc. is a medical technology company based in Issaquah, Washington, founded in 2009 by Dr. Michael Gertner. The company specializes in developing a non-invasive ultrasound-based therapy system aimed at treating hypertension and related disorders. Its primary product, Surround Sound, is a hypertension therapy system that employs ultrasound imaging to precisely deliver focused ultrasound energy for renal denervation. This innovative approach targets the nerves associated with kidney function, offering a less invasive alternative for patients suffering from drug-resistant hypertension. By leveraging advancements in therapeutic focused ultrasound, Kona Medical seeks to improve treatment efficacy and reduce the health risks associated with high blood pressure.
MuleSoft, Inc. is a provider of the Anypoint Platform, a cloud-based application integration solution that enables organizations to connect their applications, data, and devices. Founded in 2006 and headquartered in San Francisco, California, MuleSoft facilitates the creation of application networks through its flexible platform, which utilizes APIs to enable seamless communication between various systems and applications, whether cloud-based or on-premises. The platform allows customers to build reusable components, simplifying the integration process and promoting business agility. MuleSoft has established a strategic alliance with IQVIA and operates as a subsidiary of Salesforce.
Relievant Medsystems, Inc. is a medical device company focused on addressing chronic axial low back pain through a minimally invasive procedure known as Intracept. This innovative treatment specifically targets the basivertebral nerve, utilizing radio-frequency energy delivered through a small access tube into the vertebral body to ablate the nerve. The procedure is performed under real-time fluoroscopic guidance, ensuring precision and safety. Founded in 2004 and headquartered in Minneapolis, Minnesota, with an additional office in Sunnyvale, California, Relievant aims to provide low-risk therapeutic solutions that significantly improve the quality of life for patients suffering from vertebrogenic low back pain.
Promedior, Inc. is a clinical-stage biotechnology company based in Lexington, Massachusetts, focused on developing therapeutics for rare fibrotic diseases, such as idiopathic pulmonary fibrosis and myelofibrosis, as well as retinal fibrovascular diseases like age-related macular degeneration and diabetic retinopathy. The company has created a drug discovery platform that targets monocyte-derived cell populations involved in fibrotic, inflammatory, and autoimmune diseases. By addressing the source of abnormal immune responses, Promedior aims to promote tissue healing while minimizing systemic side effects associated with existing therapies. Its main products include PRM-151, a recombinant form of human pentaxin-2 protein for intravenous injection, and PRM-167, designed for intravitreal delivery. Promedior was previously known as Fibrotix, Inc. and has been a subsidiary of Roche Holding AG since February 2020.
PeopleMatter, Inc. is a workforce management platform that specializes in talent management software designed to enhance the performance of service-industry brands. Founded in 2001 and based in Charleston, South Carolina, the company provides solutions tailored for various sectors, including technology, transportation, healthcare, government, biotech, and recreation. PeopleMatter offers a comprehensive hire-to-retire system that simplifies the hiring process for hourly and shift workers, enabling managers to source, screen, and onboard employees more efficiently. By streamlining applicant tracking and onboarding, the platform aims to reduce friction in recruiting and improve overall efficiency, engagement, and customer satisfaction within the service industry. In June 2016, PeopleMatter was acquired by Snagajob.