Morgenthaler Ventures

Intermatic incorporated develops and manufactures energy controls for commercial, industrial, government and residential applications.

Skb is a company that designs and manufactures molded polymer transport cases.

Allegheny Contracting is a Pennsylvania-based company specializing in pipeline and site work contracting. It provides a comprehensive suite of specialty construction and support services, including oil and gas production, natural gas distribution and transmission, site development and restoration, hot tapping, and concrete construction. The company serves clients across Pennsylvania and the Eastern states.

Moximed, Inc. is a medical technology company based in Hayward, California, that focuses on developing innovative treatments for patients with knee osteoarthritis. The company offers the Atlas System, an implantable joint unloader designed to alleviate pain associated with medial compartment knee osteoarthritis, allowing patients to maintain high levels of activity. Additionally, Moximed has developed the MISHA Knee System, which provides an outpatient treatment option for individuals who have not responded to conventional therapies and are not suitable candidates for knee replacement surgery. By minimizing joint pain and providing dynamic load reduction, Moximed's implants aim to improve the standard of care and enhance the quality of life for patients, potentially delaying or avoiding the need for more invasive surgical interventions. Moximed has been operational since its incorporation in 2006, serving patients and medical professionals globally.

LA-CO Industries is a chemical company that specializes in manufacturing a wide range of products for various industries. The company offers plumbing chemicals, industrial and livestock marking tools, as well as temperature indicators and welding supplies. In addition, LA-CO Industries provides quality control and fabrication supplies, inks and paints, and sterilization inks. With a diverse product portfolio, the company serves sectors such as plumbing, manufacturing, and livestock management, ensuring effective solutions for identification and quality assurance.

Webster Industries is a leading manufacturer in the engineered class chain, sprockets, and vibrating equipment markets. The company specializes in producing high-quality chains intended for material handling and power transmission applications. Additionally, Webster Industries offers customized sprockets and vibratory equipment tailored to meet specific client needs. Their commitment to product excellence and evolving processes ensures that customers receive value-added solutions through empowered employees.

Family owned distributors of detail products and auto body supplies. They also conduct coating certificate courses. They provides all types of car detailing, polishing and painting.

Mid-States Bolt & Screw is a distributor specializing in standard and specialty fasteners, tools, and industrial hardware. Serving a diverse range of customers, from wholesalers and retailers to homeowners and bridge builders, the company's extensive product portfolio includes fasteners, safety equipment, abrasives, tools, and more. By offering a wide array of industrial applications, Mid-States Bolt & Screw helps its clients reduce costs, enhance productivity, and maintain optimal inventory levels.

Precision Pipeline, LLC is a pipeline contracting company that specializes in construction services for the gas and oil industry in the United States. The company focuses on both liquid and gas pipeline construction, offering a comprehensive range of services. These include transmission, gathering, and distribution, as well as maintenance and integrity testing. Precision Pipeline also provides hydrostatic testing, meter station construction, pipeline drying, and horizontal directional drilling.

Flexpipe is a manufacturer specializing in steel modular systems for lean manufacturing. The company produces a range of products, including coated steel pipes, joints, roller tracks, panels, fasteners, casters, and various related tools and accessories. By providing these components, Flexpipe aims to enhance productivity for its clients in commercial and industrial sectors.

Relievant Medsystems, Inc. is a medical device company focused on developing innovative solutions for chronic axial low back pain. Founded in 2004 and headquartered in Minneapolis, Minnesota, with a development office in Sunnyvale, California, the company has created the Intracept System. This minimally invasive procedure specifically targets the basivertebral nerve, providing relief by blocking pain signal transmission. The Intracept System offers patients a low-risk therapy option aimed at alleviating chronic vertebrogenic low back pain.

SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for the treatment of debilitating inflammatory diseases. Established in 2006 and formerly known as Innovative Metabolics Inc., the company aims to provide innovative solutions for chronic autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease. SetPoint Medical's technology leverages vagus nerve stimulation to activate the body's natural inflammatory reflex, producing a systemic anti-inflammatory effect. This platform offers an alternative treatment option that may present lower risks and costs compared to traditional drug therapies, ultimately seeking to improve patient outcomes in managing chronic inflammatory diseases.

Moximed, Inc. is a medical technology company based in Hayward, California, that focuses on developing innovative treatments for patients with knee osteoarthritis. The company offers the Atlas System, an implantable joint unloader designed to alleviate pain associated with medial compartment knee osteoarthritis, allowing patients to maintain high levels of activity. Additionally, Moximed has developed the MISHA Knee System, which provides an outpatient treatment option for individuals who have not responded to conventional therapies and are not suitable candidates for knee replacement surgery. By minimizing joint pain and providing dynamic load reduction, Moximed's implants aim to improve the standard of care and enhance the quality of life for patients, potentially delaying or avoiding the need for more invasive surgical interventions. Moximed has been operational since its incorporation in 2006, serving patients and medical professionals globally.

3D International Sd. Bhd. is a company based in Kuala Lumpur, Malaysia, that specializes in the development of hardware and software for 3D image displays. Its focus on innovative solutions in 3D visualization positions it at the forefront of the technology sector in Malaysia. The company aims to enhance visual experiences through its advanced products, catering to various applications that require high-quality 3D imaging.

Terraflos is a pioneering biotechnology company focused on developing innovative and sustainable health solutions that integrate natural substances with advanced technology. The company specializes in crafting a diverse array of products, including supplements and food items, designed to promote wellness and vitality. By employing techniques such as cellular agriculture and precision fermentation, Terraflos maximizes the potential of plants and other natural resources. Their bioactive production platform enables the creation of premium products that enhance human well-being while prioritizing environmental sustainability. Through this integrated approach, Terraflos aims to provide effective health tools that respect nature and contribute positively to climate impact.

80/20 is a manufacturer and originator of modular aluminum T-slot building systems, catering to a range of industrial and end-market applications. The company specializes in T-slot aluminum profiles that feature channels designed for connecting various components, such as panels, linear bearings, and casters. Its products are engineered to address automation challenges, support robotic applications, and create machine frames and displays. 80/20 focuses on providing customizable and scalable solutions, enabling clients to develop tailored systems that adapt to evolving requirements over time.

MSHS Group is a leading third-party MRO (maintenance, repair, and overhaul) services provider for marine and power generation applications.

SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for the treatment of debilitating inflammatory diseases. Established in 2006 and formerly known as Innovative Metabolics Inc., the company aims to provide innovative solutions for chronic autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease. SetPoint Medical's technology leverages vagus nerve stimulation to activate the body's natural inflammatory reflex, producing a systemic anti-inflammatory effect. This platform offers an alternative treatment option that may present lower risks and costs compared to traditional drug therapies, ultimately seeking to improve patient outcomes in managing chronic inflammatory diseases.

Waterfront Brands is a manufacturer based in Fergus Falls, Minnesota, specializing in a comprehensive range of boating products for both fresh and saltwater environments. The company offers an extensive lineup of premium brands, including aluminum docks, aluminum boat lifts, steel docks, steel boat lifts, and plastic floating docks. Additionally, Waterfront Brands produces roto-molding equipment and various waterfront accessories, catering to the needs of dealers and distributors across North America. Through its diverse product offerings, Waterfront Brands aims to provide quality solutions for waterfront equipment, ensuring a reliable experience for customers engaged in boating activities.

MSHS Group is a leading third-party MRO (maintenance, repair, and overhaul) services provider for marine and power generation applications.

DecoArt is a manufacturer of paints and finishes that caters to consumers, decorative painters, and crafters. The company offers a wide range of acrylic colors designed for arts, crafts, and home decorating applications, ensuring that users have access to durable and affordable products. Their product line includes various items such as lamp paints, color wheel paint sets, and a variety of colors like cadmium orange and warm sunset. DecoArt also provides free shipping on orders of $50 or more, making it convenient for customers to purchase their supplies.

Ideal Aluminum is a manufacturer specializing in premium aluminum outdoor products. They design and produce fences, gates, railings, and related items for both residential and commercial use. Their product range includes cantilevers, estate fences, ornamental gates, railings, louvers, and other durable, low-maintenance solutions to cater to diverse client needs.

Relievant Medsystems, Inc. is a medical device company focused on developing innovative solutions for chronic axial low back pain. Founded in 2004 and headquartered in Minneapolis, Minnesota, with a development office in Sunnyvale, California, the company has created the Intracept System. This minimally invasive procedure specifically targets the basivertebral nerve, providing relief by blocking pain signal transmission. The Intracept System offers patients a low-risk therapy option aimed at alleviating chronic vertebrogenic low back pain.

Teel Plastics, Inc. is a manufacturer based in Baraboo, Wisconsin, specializing in custom extruded plastic tubing and profiles. Founded in 1951 and known as Insemikit Company, Inc. until its name change in 1958, the company produces a diverse range of products, including industrial plastic cores for applications such as water softeners and refrigerators, as well as medical tubing for devices like IV sets and catheters. Teel Plastics also offers plastic profiles for various sectors, including aerospace, furniture, and appliances, along with pultruded products like door thresholds and tool handles. The company primarily serves industries such as healthcare, food, utilities, and residential and commercial construction, focusing on innovative solutions that enhance product quality and reduce environmental impact.

SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for the treatment of debilitating inflammatory diseases. Established in 2006 and formerly known as Innovative Metabolics Inc., the company aims to provide innovative solutions for chronic autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease. SetPoint Medical's technology leverages vagus nerve stimulation to activate the body's natural inflammatory reflex, producing a systemic anti-inflammatory effect. This platform offers an alternative treatment option that may present lower risks and costs compared to traditional drug therapies, ultimately seeking to improve patient outcomes in managing chronic inflammatory diseases.

Garmat USA is a manufacturer specializing in paint booths and finishing solutions tailored for various industries, including automotive, aerospace, and industrial applications. The company offers a diverse range of products such as downdraft paint booths, modified paint booths, closed-top open-front booths, waterborne booths, and mixing stations. These solutions are designed to enhance productivity and reduce operating costs for clients in collision repair, marine, and aviation sectors. Garmat USA focuses on delivering high-quality equipment that meets the specific needs of its customers, supporting their operational efficiency and effectiveness.

Garmat USA is a manufacturer specializing in paint booths and finishing solutions tailored for various industries, including automotive, aerospace, and industrial applications. The company offers a diverse range of products such as downdraft paint booths, modified paint booths, closed-top open-front booths, waterborne booths, and mixing stations. These solutions are designed to enhance productivity and reduce operating costs for clients in collision repair, marine, and aviation sectors. Garmat USA focuses on delivering high-quality equipment that meets the specific needs of its customers, supporting their operational efficiency and effectiveness.

Cantrell is a manufacturer of equipment and systems for the poultry processing industry. Cantrell has earned a reputation for designing and delivering quality products and parts that meet the needs of the poultry processing industry. Among the products the company manufactures are evisceration and picking equipment, second processing equipment, wing segmenters, vacuum systems, and spare parts. Cantrell sells its products to leading poultry processors

Nuvaira, Inc. is a medical device company based in Minneapolis, Minnesota, focused on developing innovative treatments for obstructive lung diseases, particularly chronic obstructive pulmonary disease (COPD). Founded in 2008, Nuvaira specializes in a novel catheter-based Lung Denervation System that aims to address airway nerve hyperactivity by targeting the parasympathetic innervation of the lungs. This minimally invasive procedure is designed to improve lung function, enhance exercise capacity, and elevate the quality of life for patients suffering from chronic respiratory conditions. With a commitment to advancing treatment options, Nuvaira seeks to reduce the clinical consequences associated with neural hyperactivity in conditions such as COPD and asthma.

NuoDB, Inc. is a developer of a cloud-based relational database solution designed for cloud-enabled global applications. Founded in 2008 and headquartered in Cambridge, Massachusetts, with additional offices in Dublin, London, and Belfast, the company offers a distributed SQL database that combines on-demand scalability, continuous availability, and transactional consistency. NuoDB's memory-centric architecture optimizes storage, redundancy, and replication while maintaining ACID compliance across multiple data centers. Its platform is particularly beneficial for large SaaS deployments and supports various applications, including cloud migration, hybrid workloads, and active-active operations. NuoDB also provides tools like NuoDB Insights, a graphical dashboard that allows users to monitor database health and system metrics. The company's solutions are utilized in sectors such as mobile telecommunications, financial services, and interactive entertainment, enabling customers to adapt to evolving technological demands and reduce total ownership costs. NuoDB operates as a subsidiary of Dassault Systèmes SE.

Vapotherm, Inc. is a medical technology company specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat patients of all ages experiencing respiratory distress. Headquartered in Exeter, New Hampshire, the company offers a range of precision flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through a small-bore nasal interface. Vapotherm also provides various companion products, such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air, and aerosol solutions for medication delivery. Additionally, the company offers disposable products, including single-use nasal interfaces and Oxygen Assist Modules to help clinicians maintain target oxygen levels. Vapotherm generates revenue primarily through direct sales to hospitals in the United States and through distributors in select international markets. Founded in 1993, the company is committed to enhancing clinical outcomes and improving the quality of life for patients.

Olympic Ophthalmics is a medical device company based in Issaquah, Washington, focused on developing innovative treatments for dry eye disease (DED). Founded in 2017 by Michael Gertner, the company specializes in creating devices that stimulate the trigeminal parasympathetic pathway, which activates the tear-producing glands. This approach aims to alleviate the signs and symptoms associated with chronic dry eyes, providing healthcare professionals with effective tools to enhance patient care in ocular health.

Bettcher Industries is an ISO 9001-certified manufacturing company established in 1944, known for its innovative equipment designed for the food processing, foodservice, industrial, and medical sectors. With over seventy years of experience, Bettcher Industries develops a wide range of products, including trimmers, weighing systems, food safety equipment, batter breading machines, pneumatic shears, electric gyro knives, and sharpening tools. These products enable food processing industries to efficiently transform raw materials into marketable food items while also providing solutions for industrial and medical applications that alleviate the discomfort associated with manual systems. The company serves a diverse global customer base, emphasizing quality and innovation in its manufacturing processes.

SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for the treatment of debilitating inflammatory diseases. Established in 2006 and formerly known as Innovative Metabolics Inc., the company aims to provide innovative solutions for chronic autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease. SetPoint Medical's technology leverages vagus nerve stimulation to activate the body's natural inflammatory reflex, producing a systemic anti-inflammatory effect. This platform offers an alternative treatment option that may present lower risks and costs compared to traditional drug therapies, ultimately seeking to improve patient outcomes in managing chronic inflammatory diseases.

Safe Fuel Systems is a FAA/EASA certified repair facility that focuses on the testing, repair, overhaul, and modification of fuel systems, hydraulics, and related accessories for both domestic and international operators, as well as military aircraft. The company provides 24/7 support, ensuring that clients can address their repair needs efficiently and effectively. By implementing lean management and streamlined shop floor practices, Safe Fuel Systems aims to reduce costs for its clients while maintaining high standards of quality and service.

Big Switch Networks Inc. is a provider of data center networking technologies, focusing on delivering solutions for on-premises enterprise cloud, public cloud, and multi-cloud environments. Established in 2010 and based in Santa Clara, California, the company offers a range of products, including Big Monitoring Fabric, which creates security chains for inline traffic and provides comprehensive visibility across an organization, and Big Cloud Fabric, which utilizes open networking and software-defined networking technology. These solutions aim to enhance operational efficiency, improve business agility, and lower networking costs for organizations of all sizes. Big Switch Networks is also recognized for its contributions to open source communities and maintains strategic partnerships with notable companies in the industry. The company operates globally, with a presence in over 25 countries, and has been a subsidiary of Arista Networks since 2020.

DreamLine is a manufacturer and distributor of bathroom fixtures and accessories based in Warminster, Pennsylvania. The company specializes in producing shower doors, tub doors, shower enclosures, and acrylic shower bases. DreamLine offers a range of off-the-shelf and custom shower door solutions, characterized by sleek modern designs and competitive value. Their products allow customers to customize shower fittings to meet their specific needs, providing comprehensive bathroom solutions in the bath and shower marketplace. The company has garnered worldwide recognition for its innovative offerings and commitment to quality.

Vapotherm, Inc. is a medical technology company specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat patients of all ages experiencing respiratory distress. Headquartered in Exeter, New Hampshire, the company offers a range of precision flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through a small-bore nasal interface. Vapotherm also provides various companion products, such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air, and aerosol solutions for medication delivery. Additionally, the company offers disposable products, including single-use nasal interfaces and Oxygen Assist Modules to help clinicians maintain target oxygen levels. Vapotherm generates revenue primarily through direct sales to hospitals in the United States and through distributors in select international markets. Founded in 1993, the company is committed to enhancing clinical outcomes and improving the quality of life for patients.

Moximed, Inc. is a medical technology company based in Hayward, California, that focuses on developing innovative treatments for patients with knee osteoarthritis. The company offers the Atlas System, an implantable joint unloader designed to alleviate pain associated with medial compartment knee osteoarthritis, allowing patients to maintain high levels of activity. Additionally, Moximed has developed the MISHA Knee System, which provides an outpatient treatment option for individuals who have not responded to conventional therapies and are not suitable candidates for knee replacement surgery. By minimizing joint pain and providing dynamic load reduction, Moximed's implants aim to improve the standard of care and enhance the quality of life for patients, potentially delaying or avoiding the need for more invasive surgical interventions. Moximed has been operational since its incorporation in 2006, serving patients and medical professionals globally.

Relievant Medsystems, Inc. is a medical device company focused on developing innovative solutions for chronic axial low back pain. Founded in 2004 and headquartered in Minneapolis, Minnesota, with a development office in Sunnyvale, California, the company has created the Intracept System. This minimally invasive procedure specifically targets the basivertebral nerve, providing relief by blocking pain signal transmission. The Intracept System offers patients a low-risk therapy option aimed at alleviating chronic vertebrogenic low back pain.

Miramar Labs is a medical device company based in Sunnyvale, California, founded in 2006. It specializes in developing non-invasive treatments for primary axillary hyperhidrosis, which is excessive sweating in the underarm area. The company's flagship product, the miraDry System, employs microwave energy to selectively target and permanently eliminate sweat and odor glands, providing a long-lasting solution for individuals suffering from this condition. By addressing hyperhidrosis, Miramar Labs aims to enhance the confidence and quality of life for its users. The miraDry System is specifically designed for underarm treatment and is not intended for use on other areas of the body, such as the hands and feet.

NuoDB, Inc. is a developer of a cloud-based relational database solution designed for cloud-enabled global applications. Founded in 2008 and headquartered in Cambridge, Massachusetts, with additional offices in Dublin, London, and Belfast, the company offers a distributed SQL database that combines on-demand scalability, continuous availability, and transactional consistency. NuoDB's memory-centric architecture optimizes storage, redundancy, and replication while maintaining ACID compliance across multiple data centers. Its platform is particularly beneficial for large SaaS deployments and supports various applications, including cloud migration, hybrid workloads, and active-active operations. NuoDB also provides tools like NuoDB Insights, a graphical dashboard that allows users to monitor database health and system metrics. The company's solutions are utilized in sectors such as mobile telecommunications, financial services, and interactive entertainment, enabling customers to adapt to evolving technological demands and reduce total ownership costs. NuoDB operates as a subsidiary of Dassault Systèmes SE.

Big Switch Networks Inc. is a provider of data center networking technologies, focusing on delivering solutions for on-premises enterprise cloud, public cloud, and multi-cloud environments. Established in 2010 and based in Santa Clara, California, the company offers a range of products, including Big Monitoring Fabric, which creates security chains for inline traffic and provides comprehensive visibility across an organization, and Big Cloud Fabric, which utilizes open networking and software-defined networking technology. These solutions aim to enhance operational efficiency, improve business agility, and lower networking costs for organizations of all sizes. Big Switch Networks is also recognized for its contributions to open source communities and maintains strategic partnerships with notable companies in the industry. The company operates globally, with a presence in over 25 countries, and has been a subsidiary of Arista Networks since 2020.

Vapotherm, Inc. is a medical technology company specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat patients of all ages experiencing respiratory distress. Headquartered in Exeter, New Hampshire, the company offers a range of precision flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through a small-bore nasal interface. Vapotherm also provides various companion products, such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air, and aerosol solutions for medication delivery. Additionally, the company offers disposable products, including single-use nasal interfaces and Oxygen Assist Modules to help clinicians maintain target oxygen levels. Vapotherm generates revenue primarily through direct sales to hospitals in the United States and through distributors in select international markets. Founded in 1993, the company is committed to enhancing clinical outcomes and improving the quality of life for patients.

Elcelyx Therapeutics, founded in 2010 and headquartered in San Diego, California, focuses on developing innovative treatments for diabetes and obesity-related metabolic disorders through its proprietary Gut Sensory Modulation (GSM) technology. The company's lead product candidate, NewMet, is designed to improve glucose metabolism by amplifying hormone release in the lower gut, thereby addressing significant unmet needs in the oral anti-diabetic market. Currently entering Phase 2b development, NewMet represents a potential breakthrough in diabetes management. Elcelyx also offers Lovidia, which targets similar metabolic issues without causing systemic side effects. The company is supported by a skilled management team, experienced investors, and a network of scientists and clinicians. In 2013, Elcelyx established NaZura BioHealth Inc. to focus on developing additional non-NewMet assets, further expanding its research and product pipeline.

Adara is a company that provides an online audience targeting platform designed to enhance business planning through actionable insights. By leveraging proprietary data and audience segmentation, Adara offers travel brands and advertisers a comprehensive view of their audience. This enables them to personalize their offerings effectively, aligning with specific consumer buying habits. Through its predictive analytics capabilities, Adara helps brands improve consumer engagement and gain a competitive edge in the rapidly evolving digital marketplace.

SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for the treatment of debilitating inflammatory diseases. Established in 2006 and formerly known as Innovative Metabolics Inc., the company aims to provide innovative solutions for chronic autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease. SetPoint Medical's technology leverages vagus nerve stimulation to activate the body's natural inflammatory reflex, producing a systemic anti-inflammatory effect. This platform offers an alternative treatment option that may present lower risks and costs compared to traditional drug therapies, ultimately seeking to improve patient outcomes in managing chronic inflammatory diseases.

Kona Medical, Inc. is a medical technology company that specializes in developing a non-invasive ultrasound-based therapy system aimed at treating hypertension and related disorders. Established in 2009 by Dr. Michael Gertner, the company focuses on addressing the challenges posed by drug-resistant hypertension through innovative approaches, particularly renal artery denervation. Its flagship product, Surround Sound, employs ultrasound imaging to precisely guide the delivery of focused ultrasound energy for renal denervation, offering a less invasive alternative to traditional treatments. Based in Issaquah, Washington, Kona Medical integrates Dr. Gertner's inventions with assets from Therus Corporation, enhancing its capabilities in therapeutic focused ultrasound.

Principia Biopharma Inc. is a late-stage biopharmaceutical company headquartered in South San Francisco, California, focused on developing innovative therapies for immune-mediated diseases. The company's lead product, rilzabrutinib, is an inhibitor undergoing Phase III clinical trials for pemphigus and pemphigus foliaceus, as well as Phase 1/2 trials for immune thrombocytopenia and Phase 2 trials for IgG4-related disease. Additionally, Principia is developing PRN2246/SAR442168, which is in Phase II for multiple sclerosis and other central nervous system conditions, alongside PRN473, a drug candidate in Phase I trials for immune-mediated diseases. Principia Biopharma maintains a collaboration agreement with Genzyme Corporation for the development of treatments for MS and other CNS diseases. Originally incorporated in 2008, the company is dedicated to addressing significant unmet medical needs in immunology and oncology through its innovative drug development platform.

Ra Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, focused on developing therapeutics for diseases linked to the excessive activation of the complement system. Utilizing a peptide chemistry platform, the company produces synthetic macrocyclic peptides that offer the specificity and diversity of antibodies alongside the pharmacological advantages of small molecules. Its lead product candidate, Zilucoplan, is an injectable treatment that has completed Phase II clinical trials for generalized myasthenia gravis and paroxysmal nocturnal hemoglobinuria, as well as a Phase Ib trial for patients with renal impairment. In addition to Zilucoplan, Ra Pharmaceuticals is advancing pre-clinical programs targeting Factor D inhibition for C3 glomerulonephritis and dense deposit disease, among other conditions. The company has also established a collaboration with Merck & Co., Inc. to explore orally available cyclic peptides for cardiovascular targets. Founded in 2008, Ra Pharmaceuticals operates as a subsidiary of UCB SA.

Vapotherm, Inc. is a medical technology company specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat patients of all ages experiencing respiratory distress. Headquartered in Exeter, New Hampshire, the company offers a range of precision flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through a small-bore nasal interface. Vapotherm also provides various companion products, such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air, and aerosol solutions for medication delivery. Additionally, the company offers disposable products, including single-use nasal interfaces and Oxygen Assist Modules to help clinicians maintain target oxygen levels. Vapotherm generates revenue primarily through direct sales to hospitals in the United States and through distributors in select international markets. Founded in 1993, the company is committed to enhancing clinical outcomes and improving the quality of life for patients.

Galleon Pharmaceuticals, Inc. is a pharmaceutical company based in Horsham, Pennsylvania, focused on discovering and developing innovative treatments for sleep apnea and related breathing control disorders. Established in 2003, the company is engaged in creating a portfolio of therapeutics aimed at addressing a variety of respiratory conditions, including sleep apnea, ventilator weaning, anesthetic-induced respiratory depression, chronic obstructive pulmonary disease (COPD), and obesity-hypoventilation syndrome. Among its key offerings are GAL-021, an intravenous small molecule that supports respiratory drive in surgical and critical care patients, GLN-21,160, an oral candidate for sleep apnea, and GAL-044, which serves as a preventative medication for surgical pain. Galleon Pharmaceuticals is committed to enhancing patient care through its neuro-respiratory drug development initiatives.

MuleSoft is a San Francisco-based company that provides a software platform, Anypoint Platform, enabling organizations to connect their applications, data, and devices seamlessly using APIs (Application Programming Interfaces). Founded in 2006, MuleSoft's platform allows customers to compose applications using reusable building blocks or nodes, facilitating connections between SaaS applications, on-premises systems, cloud deployments, mobile devices, and data sources. The company operates as a subsidiary of Salesforce.com since 2018 and has strategic alliances with other businesses like IQVIA.

Moximed, Inc. is a medical technology company based in Hayward, California, that focuses on developing innovative treatments for patients with knee osteoarthritis. The company offers the Atlas System, an implantable joint unloader designed to alleviate pain associated with medial compartment knee osteoarthritis, allowing patients to maintain high levels of activity. Additionally, Moximed has developed the MISHA Knee System, which provides an outpatient treatment option for individuals who have not responded to conventional therapies and are not suitable candidates for knee replacement surgery. By minimizing joint pain and providing dynamic load reduction, Moximed's implants aim to improve the standard of care and enhance the quality of life for patients, potentially delaying or avoiding the need for more invasive surgical interventions. Moximed has been operational since its incorporation in 2006, serving patients and medical professionals globally.

Twelve manufactures medical devices. It was formerly known as Foundry Newco XII, Inc. The company was incorporated in 2009 and is based in Menlo Park, California.

NuoDB, Inc. is a developer of a cloud-based relational database solution designed for cloud-enabled global applications. Founded in 2008 and headquartered in Cambridge, Massachusetts, with additional offices in Dublin, London, and Belfast, the company offers a distributed SQL database that combines on-demand scalability, continuous availability, and transactional consistency. NuoDB's memory-centric architecture optimizes storage, redundancy, and replication while maintaining ACID compliance across multiple data centers. Its platform is particularly beneficial for large SaaS deployments and supports various applications, including cloud migration, hybrid workloads, and active-active operations. NuoDB also provides tools like NuoDB Insights, a graphical dashboard that allows users to monitor database health and system metrics. The company's solutions are utilized in sectors such as mobile telecommunications, financial services, and interactive entertainment, enabling customers to adapt to evolving technological demands and reduce total ownership costs. NuoDB operates as a subsidiary of Dassault Systèmes SE.

dlhBOWLES is a leading manufacturer of plastic air and fluid handling assemblies, tubing, hoses, and profile extrusions, serving the automotive sector and other industries. Established in 1975 and based in Canton, Ohio, the company specializes in the design, development, and production of automotive fluid management systems and components, including washer systems, powertrain and chassis parts, and electric vehicle thermal management solutions. With over fifty years of experience, dlhBOWLES has supplied more than a quarter of a billion components to major automakers, demonstrating its commitment to high-quality and cost-effective products. The company also provides engineering and manufacturing services, rapid prototyping, and lab testing, which enhance its capacity to deliver reliable and innovative solutions for diverse applications. As a subsidiary of Bowles Fluidics Corporation, dlhBOWLES continues to expand its technological capabilities and product offerings globally.

Sunlight Aerospace is a developer of autonomous unmanned aerial vehicles (UAVs) that specialize in airborne wireless communications systems. The company focuses on creating fleets of solar-powered UAVs, known as Sunfleets, which feature advanced airframe designs, lightweight photovoltaic technology, and formation flight control systems. These UAVs are engineered for high-altitude, long-endurance missions and serve as platforms for innovative airborne wireless communication networks, offering broadband internet services. By leveraging solar and hybrid power solutions, Sunlight Aerospace addresses the demand for efficient, sustainable UAV technology capable of performing effectively in both low and high-altitude environments, enabling comprehensive flight control, power management, and communication operations.

Socrata, Inc. is a leading provider of cloud-based software solutions aimed at enhancing the accessibility and usability of government data for public agencies and the communities they serve. Founded in 2007 and based in Seattle, Washington, with additional offices in Washington, D.C. and London, the company offers a suite of products that include Open Data, Open Performance, and Perspectives, all designed to facilitate interaction with data and improve transparency. Socrata's platform enables government workers, policymakers, and citizens to create visualizations, analyze performance metrics, and access crucial financial information. Its offerings also include tools like CrimeReports, Open Budget, Open Expenditures, and Open Payroll, which promote engagement and accountability in public administration. Socrata focuses exclusively on federal, state, and local government organizations, utilizing a data-as-a-service model optimized for cloud performance. The company operates under strict government standards and has achieved FedRAMP Authority to Operate, underscoring its commitment to security and reliability in public sector applications.

Miramar Labs is a medical device company based in Sunnyvale, California, founded in 2006. It specializes in developing non-invasive treatments for primary axillary hyperhidrosis, which is excessive sweating in the underarm area. The company's flagship product, the miraDry System, employs microwave energy to selectively target and permanently eliminate sweat and odor glands, providing a long-lasting solution for individuals suffering from this condition. By addressing hyperhidrosis, Miramar Labs aims to enhance the confidence and quality of life for its users. The miraDry System is specifically designed for underarm treatment and is not intended for use on other areas of the body, such as the hands and feet.

Ivantis Inc. is a medical device company based in Irvine, California, focused on developing innovative treatments for primary open-angle glaucoma. Founded in 2007, the company has created a minimally invasive intracanalicular scaffold that helps alleviate high intraocular pressure by restoring the natural drainage pathway in Schlemm's canal. This device aims to provide a less invasive and more effective solution for the over 60 million individuals worldwide affected by this condition. In addition to its glaucoma treatments, Ivantis plans to expand its research and development efforts to address other challenging diseases within the field of ophthalmology. The company's products are utilized in clinical trials by ophthalmology specialists across the United States.

Principia Biopharma Inc. is a late-stage biopharmaceutical company headquartered in South San Francisco, California, focused on developing innovative therapies for immune-mediated diseases. The company's lead product, rilzabrutinib, is an inhibitor undergoing Phase III clinical trials for pemphigus and pemphigus foliaceus, as well as Phase 1/2 trials for immune thrombocytopenia and Phase 2 trials for IgG4-related disease. Additionally, Principia is developing PRN2246/SAR442168, which is in Phase II for multiple sclerosis and other central nervous system conditions, alongside PRN473, a drug candidate in Phase I trials for immune-mediated diseases. Principia Biopharma maintains a collaboration agreement with Genzyme Corporation for the development of treatments for MS and other CNS diseases. Originally incorporated in 2008, the company is dedicated to addressing significant unmet medical needs in immunology and oncology through its innovative drug development platform.

ForSight VISION5, founded in 2010 as part of ForSight Labs, specializes in the development of non-invasive drug delivery technologies aimed at treating major eye diseases such as glaucoma, dry eye, and allergies. The company is focused on creating innovative products that can replace traditional eye drops and offer sustained therapeutic effects. Currently, ForSight VISION5 is advancing its lead product, the Helios insert, which is undergoing its second Phase 2 clinical study, reflecting the company's commitment to improving patient care in ophthalmology through effective and patient-friendly solutions.

ForSight Labs is a company dedicated to developing innovative ophthalmic technologies aimed at improving the sight, care, and quality of life for visually impaired patients. With a focus on addressing the significant challenges posed by vision loss, including conditions like glaucoma, ForSight Labs collaborates with a team of motivated professionals, clinicians, and investors to bring new solutions to the ophthalmic community. The company recognizes the profound impact of vision impairment on individuals and society, as the number of people suffering from visual impairment is expected to increase significantly in the coming years. By driving the development and commercialization of high-impact eye care technologies, ForSight Labs aims to deliver effective treatments that enhance patient outcomes and address the substantial economic burden associated with vision loss.

Vapotherm, Inc. is a medical technology company specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat patients of all ages experiencing respiratory distress. Headquartered in Exeter, New Hampshire, the company offers a range of precision flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through a small-bore nasal interface. Vapotherm also provides various companion products, such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air, and aerosol solutions for medication delivery. Additionally, the company offers disposable products, including single-use nasal interfaces and Oxygen Assist Modules to help clinicians maintain target oxygen levels. Vapotherm generates revenue primarily through direct sales to hospitals in the United States and through distributors in select international markets. Founded in 1993, the company is committed to enhancing clinical outcomes and improving the quality of life for patients.

Nuvaira, Inc. is a medical device company based in Minneapolis, Minnesota, focused on developing innovative treatments for obstructive lung diseases, particularly chronic obstructive pulmonary disease (COPD). Founded in 2008, Nuvaira specializes in a novel catheter-based Lung Denervation System that aims to address airway nerve hyperactivity by targeting the parasympathetic innervation of the lungs. This minimally invasive procedure is designed to improve lung function, enhance exercise capacity, and elevate the quality of life for patients suffering from chronic respiratory conditions. With a commitment to advancing treatment options, Nuvaira seeks to reduce the clinical consequences associated with neural hyperactivity in conditions such as COPD and asthma.

MuleSoft is a San Francisco-based company that provides a software platform, Anypoint Platform, enabling organizations to connect their applications, data, and devices seamlessly using APIs (Application Programming Interfaces). Founded in 2006, MuleSoft's platform allows customers to compose applications using reusable building blocks or nodes, facilitating connections between SaaS applications, on-premises systems, cloud deployments, mobile devices, and data sources. The company operates as a subsidiary of Salesforce.com since 2018 and has strategic alliances with other businesses like IQVIA.

NuoDB, Inc. is a developer of a cloud-based relational database solution designed for cloud-enabled global applications. Founded in 2008 and headquartered in Cambridge, Massachusetts, with additional offices in Dublin, London, and Belfast, the company offers a distributed SQL database that combines on-demand scalability, continuous availability, and transactional consistency. NuoDB's memory-centric architecture optimizes storage, redundancy, and replication while maintaining ACID compliance across multiple data centers. Its platform is particularly beneficial for large SaaS deployments and supports various applications, including cloud migration, hybrid workloads, and active-active operations. NuoDB also provides tools like NuoDB Insights, a graphical dashboard that allows users to monitor database health and system metrics. The company's solutions are utilized in sectors such as mobile telecommunications, financial services, and interactive entertainment, enabling customers to adapt to evolving technological demands and reduce total ownership costs. NuoDB operates as a subsidiary of Dassault Systèmes SE.

Elcelyx Therapeutics, founded in 2010 and headquartered in San Diego, California, focuses on developing innovative treatments for diabetes and obesity-related metabolic disorders through its proprietary Gut Sensory Modulation (GSM) technology. The company's lead product candidate, NewMet, is designed to improve glucose metabolism by amplifying hormone release in the lower gut, thereby addressing significant unmet needs in the oral anti-diabetic market. Currently entering Phase 2b development, NewMet represents a potential breakthrough in diabetes management. Elcelyx also offers Lovidia, which targets similar metabolic issues without causing systemic side effects. The company is supported by a skilled management team, experienced investors, and a network of scientists and clinicians. In 2013, Elcelyx established NaZura BioHealth Inc. to focus on developing additional non-NewMet assets, further expanding its research and product pipeline.

HealthLoop, Inc. is a healthcare technology company that offers a software-as-a-service (SaaS) platform designed to enhance patient engagement and support recovery processes. Founded in 2009 and headquartered in Moffett Field, California, the platform allows medical practices to monitor patient signs and symptoms while facilitating communication during recovery. By collecting feedback and tracking patient progress, HealthLoop helps doctors identify individuals at risk of complications, treatment failures, or hospital readmissions. The platform engages patients before their hospital admission and continues to guide them after discharge, thereby improving care coordination and ultimately aiming for better health outcomes. It primarily serves medical offices across the United States.

Calithera Biosciences, Inc. is a clinical-stage biopharmaceutical company focused on the discovery and development of small molecule drugs targeting tumor metabolism and immunology for cancer treatment. Headquartered in South San Francisco, California, the company’s lead product candidate, CB-839, is an inhibitor of glutaminase currently in Phase II clinical trials for solid tumors. Additionally, Calithera is developing INCB001158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology, as well as CB-280, another oral arginase inhibitor aimed at treating cystic fibrosis, and CB-708, an orally administered small molecule inhibitor of CD73. The company has established collaborations with Bristol-Myers Squibb to evaluate the combination of nivolumab with CB-839, and with Incyte Corporation for the development and commercialization of INCB001158. Founded in 2010, Calithera Biosciences is dedicated to advancing innovative therapies that specifically target critical pathways in tumor growth and survival.

PeopleMatter, Inc. is a workforce management platform that specializes in talent management software aimed at enhancing business performance through effective workforce measurement. Founded in 2001 and based in Charleston, South Carolina, the company provides tailored solutions for various industries, including technology, transportation, healthcare, government, biotech, and recreation. Its platform is designed to assist hourly hiring managers by streamlining the processes of sourcing, screening, and onboarding hourly workers, thereby improving efficiency and engagement. PeopleMatter's tools help service-industry brands optimize their recruitment efforts, ultimately contributing to improved customer satisfaction. In June 2016, the company was acquired by Snagajob, further expanding its reach and capabilities in the workforce management space.

Practice Fusion, Inc. is a cloud-based electronic health records (EHR) company based in San Francisco, California, founded in 2005. The company specializes in providing a comprehensive practice management software platform that facilitates various healthcare functions, including charting, scheduling, billing, e-prescribing, lab integrations, and secure messaging. By connecting doctors, patients, and data, Practice Fusion aims to enhance healthcare delivery and improve patient outcomes. Its platform serves a diverse range of users, including independent medical practices, large medical groups, and community clinics, as well as life science partners. Additionally, Practice Fusion Insight offers a healthcare database to support medical professionals in their practice. As of February 2018, Practice Fusion operates as a subsidiary of Allscripts Healthcare Solutions, Inc.

Convo is an enterprise social collaboration platform that facilitates secure communication between desk and non-desk workers, aiming to enhance productivity and engagement within organizations. The platform distinguishes itself from traditional email and chat-based solutions by merging the simplicity of social networks with comprehensive collaboration features, allowing for streamlined work interactions without the need for email. Convo's user-friendly interface includes a newsfeed format, enabling teams to chat, upload files, highlight content, and comment efficiently. This design promotes fast, focused, and secure discussions, making it an effective tool for modern workplace communication.

Mint Bills is an application designed to help users manage their finances by setting reminders for bill payments. It employs proprietary account aggregation technology to ensure secure payment processing within its mobile applications. The primary service offered by Mint Bills allows users to pay bills and monitor their bank accounts, credit card transactions, investments, and loan balances through a user-friendly interface. The application is available on both iOS and Android platforms, making it accessible to a wide range of users.

SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for the treatment of debilitating inflammatory diseases. Established in 2006 and formerly known as Innovative Metabolics Inc., the company aims to provide innovative solutions for chronic autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease. SetPoint Medical's technology leverages vagus nerve stimulation to activate the body's natural inflammatory reflex, producing a systemic anti-inflammatory effect. This platform offers an alternative treatment option that may present lower risks and costs compared to traditional drug therapies, ultimately seeking to improve patient outcomes in managing chronic inflammatory diseases.

Socrata, Inc. is a leading provider of cloud-based software solutions aimed at enhancing the accessibility and usability of government data for public agencies and the communities they serve. Founded in 2007 and based in Seattle, Washington, with additional offices in Washington, D.C. and London, the company offers a suite of products that include Open Data, Open Performance, and Perspectives, all designed to facilitate interaction with data and improve transparency. Socrata's platform enables government workers, policymakers, and citizens to create visualizations, analyze performance metrics, and access crucial financial information. Its offerings also include tools like CrimeReports, Open Budget, Open Expenditures, and Open Payroll, which promote engagement and accountability in public administration. Socrata focuses exclusively on federal, state, and local government organizations, utilizing a data-as-a-service model optimized for cloud performance. The company operates under strict government standards and has achieved FedRAMP Authority to Operate, underscoring its commitment to security and reliability in public sector applications.

ForSight Labs is a company dedicated to developing innovative ophthalmic technologies aimed at improving the sight, care, and quality of life for visually impaired patients. With a focus on addressing the significant challenges posed by vision loss, including conditions like glaucoma, ForSight Labs collaborates with a team of motivated professionals, clinicians, and investors to bring new solutions to the ophthalmic community. The company recognizes the profound impact of vision impairment on individuals and society, as the number of people suffering from visual impairment is expected to increase significantly in the coming years. By driving the development and commercialization of high-impact eye care technologies, ForSight Labs aims to deliver effective treatments that enhance patient outcomes and address the substantial economic burden associated with vision loss.

Automatic's mission is to empower drivers with knowledge about themselves and their cars so they can be safer and drive smarter. Automatic believes that drivers should not have to buy a new car to have a better driving experience, and that the phone in their pocket can bring the future of driving to today's automobiles. Automatic is based in San Francisco, California, but its team comes from every corner of the world. The team obsesses about creating beautiful and well-engineered products that make a real difference in people's lives. Its members are big on ideas, low on ego, and love working together.

Scioderm, LLC is a clinical-stage pharmaceutical company based in Durham, North Carolina, specializing in the research, development, and manufacturing of drugs for chronic skin diseases, particularly epidermolysis bullosa (EB). The company is focused on creating topical therapies to meet critical medical needs in dermatology. Its lead product, Zorblisa, is an investigational therapy aimed at treating the skin blistering and lesions associated with EB, a rare genetic disorder characterized by fragile skin. Zorblisa promotes the healing of existing skin lesions and aims to reduce the incidence and severity of new lesions. Founded in 2012, Scioderm operates as a subsidiary of Amicus Therapeutics, Inc.

Vapotherm, Inc. is a medical technology company specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat patients of all ages experiencing respiratory distress. Headquartered in Exeter, New Hampshire, the company offers a range of precision flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through a small-bore nasal interface. Vapotherm also provides various companion products, such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air, and aerosol solutions for medication delivery. Additionally, the company offers disposable products, including single-use nasal interfaces and Oxygen Assist Modules to help clinicians maintain target oxygen levels. Vapotherm generates revenue primarily through direct sales to hospitals in the United States and through distributors in select international markets. Founded in 1993, the company is committed to enhancing clinical outcomes and improving the quality of life for patients.

MuleSoft is a San Francisco-based company that provides a software platform, Anypoint Platform, enabling organizations to connect their applications, data, and devices seamlessly using APIs (Application Programming Interfaces). Founded in 2006, MuleSoft's platform allows customers to compose applications using reusable building blocks or nodes, facilitating connections between SaaS applications, on-premises systems, cloud deployments, mobile devices, and data sources. The company operates as a subsidiary of Salesforce.com since 2018 and has strategic alliances with other businesses like IQVIA.

Catalyst Biosciences, Inc. is a clinical-stage biopharmaceutical company headquartered in South San Francisco, California. The company specializes in developing innovative treatments for hemophilia and other rare bleeding disorders, utilizing its engineered subcutaneous coagulation factors to promote blood clotting. This approach aims to address the inherent limitations of traditional intravenous treatments and improve patient outcomes. Catalyst's product portfolio includes Marzeptacog alfa (activated), an advanced coagulation Factor VIIa that has completed Phase II development for hemophilia A or B with inhibitors, and Dalcinonacog alfa, a next-generation Factor IX therapy that has finished Phase IIb clinical trials for hemophilia B. Additionally, the company is working on CB 2679d-GT, an early-stage gene therapy for hemophilia B, as well as other treatments targeting dry age-related macular degeneration and systemic complement inhibitors. Catalyst Biosciences has also formed strategic collaborations with Mosaic Biosciences and Biogen to enhance its research and development efforts in these therapeutic areas. The company was founded in 2002 and has a commitment to addressing unmet medical needs in coagulation and complement disorders.

PeopleMatter, Inc. is a workforce management platform that specializes in talent management software aimed at enhancing business performance through effective workforce measurement. Founded in 2001 and based in Charleston, South Carolina, the company provides tailored solutions for various industries, including technology, transportation, healthcare, government, biotech, and recreation. Its platform is designed to assist hourly hiring managers by streamlining the processes of sourcing, screening, and onboarding hourly workers, thereby improving efficiency and engagement. PeopleMatter's tools help service-industry brands optimize their recruitment efforts, ultimately contributing to improved customer satisfaction. In June 2016, the company was acquired by Snagajob, further expanding its reach and capabilities in the workforce management space.

Adara is a company that provides an online audience targeting platform designed to enhance business planning through actionable insights. By leveraging proprietary data and audience segmentation, Adara offers travel brands and advertisers a comprehensive view of their audience. This enables them to personalize their offerings effectively, aligning with specific consumer buying habits. Through its predictive analytics capabilities, Adara helps brands improve consumer engagement and gain a competitive edge in the rapidly evolving digital marketplace.

Nuvaira, Inc. is a medical device company based in Minneapolis, Minnesota, focused on developing innovative treatments for obstructive lung diseases, particularly chronic obstructive pulmonary disease (COPD). Founded in 2008, Nuvaira specializes in a novel catheter-based Lung Denervation System that aims to address airway nerve hyperactivity by targeting the parasympathetic innervation of the lungs. This minimally invasive procedure is designed to improve lung function, enhance exercise capacity, and elevate the quality of life for patients suffering from chronic respiratory conditions. With a commitment to advancing treatment options, Nuvaira seeks to reduce the clinical consequences associated with neural hyperactivity in conditions such as COPD and asthma.

OptiScan Biomedical Corporation, founded in 1994 and located in Hayward, California, specializes in developing bedside blood monitoring systems for critically ill patients in intensive care units (ICUs). The company's flagship product, the OptiScanner 5000, is an automated glucose monitoring platform that utilizes spectroscopy technology to measure plasma glucose levels directly, eliminating the need for calibration. This system enables healthcare providers to rapidly detect changes in glucose levels, thus supporting better management of critically ill patients' health.

R2 Semiconductor, Inc. is a fabless semiconductor company based in Sunnyvale, California, founded in 2008. The company specializes in power management technology, focusing on low-voltage transistors that enhance efficiency in various applications. Its product offerings include FasTrack, which supports envelope tracking, and FastLane, designed to optimize power management for multi-core application processors and digital System on Chips (SoCs). R2 Semiconductor aims to reduce power consumption and heat dissipation in devices, thereby improving frequency switching, bandwidth, and overall size. The company is led by industry veterans with extensive experience in semiconductor manufacturing.

RelateIQ, now part of Salesforce, is a professional relationship management platform that has transformed customer relationship management by introducing the world's first Relationship Intelligence platform. It automatically gathers and organizes communications data from various sources, including email, phone calls, calendars, and social networks, enabling users to track interactions with sales prospects seamlessly. The platform enhances collaboration among team members, facilitating quicker deal closures and driving revenue growth. With its advanced data science capabilities, RelateIQ provides actionable insights, often before users are aware of their needs. This innovative approach not only saves time but also streamlines workflows, making the process of managing customer relationships more efficient and less burdensome.

Calithera Biosciences, Inc. is a clinical-stage biopharmaceutical company focused on the discovery and development of small molecule drugs targeting tumor metabolism and immunology for cancer treatment. Headquartered in South San Francisco, California, the company’s lead product candidate, CB-839, is an inhibitor of glutaminase currently in Phase II clinical trials for solid tumors. Additionally, Calithera is developing INCB001158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology, as well as CB-280, another oral arginase inhibitor aimed at treating cystic fibrosis, and CB-708, an orally administered small molecule inhibitor of CD73. The company has established collaborations with Bristol-Myers Squibb to evaluate the combination of nivolumab with CB-839, and with Incyte Corporation for the development and commercialization of INCB001158. Founded in 2010, Calithera Biosciences is dedicated to advancing innovative therapies that specifically target critical pathways in tumor growth and survival.

Kona Medical, Inc. is a medical technology company that specializes in developing a non-invasive ultrasound-based therapy system aimed at treating hypertension and related disorders. Established in 2009 by Dr. Michael Gertner, the company focuses on addressing the challenges posed by drug-resistant hypertension through innovative approaches, particularly renal artery denervation. Its flagship product, Surround Sound, employs ultrasound imaging to precisely guide the delivery of focused ultrasound energy for renal denervation, offering a less invasive alternative to traditional treatments. Based in Issaquah, Washington, Kona Medical integrates Dr. Gertner's inventions with assets from Therus Corporation, enhancing its capabilities in therapeutic focused ultrasound.

Big Switch Networks Inc. is a provider of data center networking technologies, focusing on delivering solutions for on-premises enterprise cloud, public cloud, and multi-cloud environments. Established in 2010 and based in Santa Clara, California, the company offers a range of products, including Big Monitoring Fabric, which creates security chains for inline traffic and provides comprehensive visibility across an organization, and Big Cloud Fabric, which utilizes open networking and software-defined networking technology. These solutions aim to enhance operational efficiency, improve business agility, and lower networking costs for organizations of all sizes. Big Switch Networks is also recognized for its contributions to open source communities and maintains strategic partnerships with notable companies in the industry. The company operates globally, with a presence in over 25 countries, and has been a subsidiary of Arista Networks since 2020.

Principia Biopharma Inc. is a late-stage biopharmaceutical company headquartered in South San Francisco, California, focused on developing innovative therapies for immune-mediated diseases. The company's lead product, rilzabrutinib, is an inhibitor undergoing Phase III clinical trials for pemphigus and pemphigus foliaceus, as well as Phase 1/2 trials for immune thrombocytopenia and Phase 2 trials for IgG4-related disease. Additionally, Principia is developing PRN2246/SAR442168, which is in Phase II for multiple sclerosis and other central nervous system conditions, alongside PRN473, a drug candidate in Phase I trials for immune-mediated diseases. Principia Biopharma maintains a collaboration agreement with Genzyme Corporation for the development of treatments for MS and other CNS diseases. Originally incorporated in 2008, the company is dedicated to addressing significant unmet medical needs in immunology and oncology through its innovative drug development platform.

Promedior, Inc. is a clinical-stage biotechnology company based in Lexington, Massachusetts, focused on developing innovative therapeutics for rare fibrotic diseases and retinal fibrovascular conditions. The company targets conditions such as myelofibrosis, idiopathic pulmonary fibrosis, age-related macular degeneration, and diabetic retinopathy. Promedior's portfolio includes PRM-151, a recombinant form of human pentaxin-2 protein designed for intravenous injection, and PRM-167, a variant formulated for intravitreal delivery. Promedior employs a novel drug discovery platform that aims to regulate monocyte-derived cell populations, which are critical in inflammatory, fibrotic, and autoimmune diseases. By specifically addressing these cells at the injury site, Promedior seeks to treat the underlying causes of immune system dysregulation, promote tissue healing, and minimize systemic side effects associated with traditional therapies. The company's commitment to addressing severe and challenging conditions positions it as a significant player in the biopharmaceutical landscape.

Catalyst Biosciences, Inc. is a clinical-stage biopharmaceutical company headquartered in South San Francisco, California. The company specializes in developing innovative treatments for hemophilia and other rare bleeding disorders, utilizing its engineered subcutaneous coagulation factors to promote blood clotting. This approach aims to address the inherent limitations of traditional intravenous treatments and improve patient outcomes. Catalyst's product portfolio includes Marzeptacog alfa (activated), an advanced coagulation Factor VIIa that has completed Phase II development for hemophilia A or B with inhibitors, and Dalcinonacog alfa, a next-generation Factor IX therapy that has finished Phase IIb clinical trials for hemophilia B. Additionally, the company is working on CB 2679d-GT, an early-stage gene therapy for hemophilia B, as well as other treatments targeting dry age-related macular degeneration and systemic complement inhibitors. Catalyst Biosciences has also formed strategic collaborations with Mosaic Biosciences and Biogen to enhance its research and development efforts in these therapeutic areas. The company was founded in 2002 and has a commitment to addressing unmet medical needs in coagulation and complement disorders.

Nuvaira, Inc. is a medical device company based in Minneapolis, Minnesota, focused on developing innovative treatments for obstructive lung diseases, particularly chronic obstructive pulmonary disease (COPD). Founded in 2008, Nuvaira specializes in a novel catheter-based Lung Denervation System that aims to address airway nerve hyperactivity by targeting the parasympathetic innervation of the lungs. This minimally invasive procedure is designed to improve lung function, enhance exercise capacity, and elevate the quality of life for patients suffering from chronic respiratory conditions. With a commitment to advancing treatment options, Nuvaira seeks to reduce the clinical consequences associated with neural hyperactivity in conditions such as COPD and asthma.

Doximity is a digital platform designed exclusively for medical professionals in the United States. With over 70% of U.S. physicians as members across various specialties and practice areas, Doximity offers a suite of tools tailored to enhance productivity and collaboration among healthcare providers. These tools enable doctors to communicate with colleagues, coordinate patient care securely, conduct virtual patient visits, stay informed about the latest medical news and research, and manage their careers effectively. The platform's mission is to support doctors in providing better healthcare by streamlining their professional activities.

ForSight VISION5, founded in 2010 as part of ForSight Labs, specializes in the development of non-invasive drug delivery technologies aimed at treating major eye diseases such as glaucoma, dry eye, and allergies. The company is focused on creating innovative products that can replace traditional eye drops and offer sustained therapeutic effects. Currently, ForSight VISION5 is advancing its lead product, the Helios insert, which is undergoing its second Phase 2 clinical study, reflecting the company's commitment to improving patient care in ophthalmology through effective and patient-friendly solutions.