Orthofix International

SeaSpine Holdings Corporation is a medical technology company dedicated to designing, developing, and commercializing surgical solutions for spinal disorders. It offers a comprehensive range of orthobiologics and spinal implant products tailored for neurosurgeons and orthopedic spine surgeons performing fusion procedures across the lumbar, thoracic, and cervical spine. Its orthobiologics portfolio includes demineralized bone matrices, collagen ceramic matrices, and synthetic bone void fillers, which aim to enhance bone fusion rates in various orthopedic surgeries. Additionally, SeaSpine's spinal implant offerings include devices for spinal decompression, alignment, and stabilization, facilitating fusion in both complex and minimally invasive procedures. The company also collaborates with restor3d, Inc. to develop 3D-printed interbody devices. Headquartered in Carlsbad, California, SeaSpine operates in North America, Europe, Asia-Pacific, and Latin America, generating revenue through consignment and loaning of its products to hospitals and independent sales agents.

Neo Medical SA is a medical technology company based in Villette, Switzerland, with additional offices in Germany, France, and the United States. Founded in 2013, the company specializes in developing, manufacturing, and commercializing non-constraint thoraco-lumbar spinal fusion systems for spinal surgery. Its flagship product, the Neo Pedicle Screw System, offers a range of functionalities such as reduction, compression, distraction, and screw augmentation, addressing various pathologies including degenerative conditions, tumors, and trauma. Neo Medical aims to enhance the efficiency of healthcare delivery by providing versatile and high-quality surgical solutions, thereby contributing to the ongoing pursuit of healthcare cost optimization.

Bone Biologics Corporation is a medical device company based in Burlington, Massachusetts, specializing in bone regeneration technologies. The company focuses on the development and commercialization of its lead product, NELL-1, a recombinant human protein that promotes bone growth and repair. NELL-1 is designed for use in spinal fusion procedures, particularly for skeletally mature patients suffering from degenerative disc disease. The proprietary NELL-1 technology provides targeted control over bone regeneration and has potential applications in various surgical fields, including spinal surgery, orthopedics, plastic reconstruction, neurosurgery, interventional radiology, and sports medicine. Bone Biologics was founded in 2004 and has established a license agreement with the UCLA Technology Development Group to further advance its spinal fusion applications.

Spinal Kinetics LLC is a medical device company based in Sunnyvale, California, founded in 2003. The company specializes in the design and development of non-fusion motion preservation systems for treating degenerative diseases of the cervical and lumbar spine. Its flagship products, the M6-C and M6-L artificial discs, offer innovative options for artificial cervical and lumbar disc replacements, respectively. These discs are uniquely engineered to replicate the anatomical and biomechanical properties of natural intervertebral discs by incorporating an artificial nucleus and annulus. Spinal Kinetics collaborates with spine surgeons to enhance the effectiveness of its devices, which are distributed in various countries, including Australia, Germany, Spain, and the United Kingdom. The company operates as a subsidiary of Orthofix Medical Inc.

Innovative Spinal Technologies is a spine technology company based in Mansfield, Massachusetts, established in 2002. The company specializes in the development of motion preservation and minimally invasive treatments for spinal disorders. Its product portfolio includes the AXIENT Dynamic Fixation system, a pedicle screw-based motion system, and the PARAMOUNT Lumbar Fusion System, designed for lumbar fusion procedures in various surgical approaches, including minimally invasive and open techniques. Additionally, the PARAMOUNT MIS Pedicle Screw System caters to both single and multi-level procedures, while the PARAMOUNT Open Pedicle Screw System is tailored for minimally invasive lumbar fusion. The PARAMOUNT VBR is specifically engineered for a minimally invasive transforaminal approach, reflecting the company’s commitment to advancing spinal care through innovative technologies.