ProQuest Investments

SomaLogic, Inc. is a commercial-stage company based in Boulder, Colorado, specializing in protein biomarker discovery and clinical diagnostics. Founded in 1999, the company has developed advanced technologies such as SOMAmers, slow off-rate modified aptamers that specifically bind to target proteins, and the SOMAscan platform, which facilitates comprehensive protein measurement. This innovative approach allows for the analysis of protein biomarker signatures, significantly enhancing the understanding of health and disease beyond traditional genomic methods. SomaLogic's products are utilized in a variety of applications, including diagnostics for conditions in oncology, neurology, and cardiovascular and metabolic diseases, as well as in drug discovery and development. The company also offers diagnostic tests and protein measurement solutions for life science and biopharma researchers, contributing to advancements in medical science.

ReVision Optics, Inc. is a company that specializes in designing, manufacturing, and delivering implantable products aimed at treating presbyopia, a condition associated with the natural aging process that affects near vision. The company's flagship product, the PRESBYLENS Corneal Inlay, offers a patented refractive surgery solution that enhances visual acuity for individuals experiencing age-related vision loss. Founded in 1996 and based in Lake Forest, California, ReVision Optics serves ophthalmology professionals, providing them with advanced technology to improve patient outcomes. Originally established as IntraLens Vision, Inc., the company rebranded to its current name in 2005, reflecting its focus on innovative optical solutions.

Agile Therapeutics, Inc. is a women's healthcare company based in Princeton, New Jersey, dedicated to the research, development, and commercialization of prescription contraceptive products. The company's lead product is Twirla, a once-weekly transdermal contraceptive patch that combines levonorgestrel and ethinyl estradiol, designed to provide a non-daily option for contraception. Agile Therapeutics is also advancing a pipeline of additional products and extensions related to Twirla, including regimens aimed at offering women extended cycles, shorter and lighter periods, and a progestin-only patch for those who cannot or prefer not to use estrogen. Utilizing proprietary Skinfusion technology, the company aims to deliver effective contraceptive solutions that address the unmet health needs of women today. Founded in 1997, Agile Therapeutics continues to focus on innovating women's healthcare options.

SomaLogic, Inc. is a commercial-stage company based in Boulder, Colorado, specializing in protein biomarker discovery and clinical diagnostics. Founded in 1999, the company has developed advanced technologies such as SOMAmers, slow off-rate modified aptamers that specifically bind to target proteins, and the SOMAscan platform, which facilitates comprehensive protein measurement. This innovative approach allows for the analysis of protein biomarker signatures, significantly enhancing the understanding of health and disease beyond traditional genomic methods. SomaLogic's products are utilized in a variety of applications, including diagnostics for conditions in oncology, neurology, and cardiovascular and metabolic diseases, as well as in drug discovery and development. The company also offers diagnostic tests and protein measurement solutions for life science and biopharma researchers, contributing to advancements in medical science.

Mevion Medical Systems, Inc. is a company specializing in the development of proton therapy systems for cancer treatment. Founded in 2004 and headquartered in Littleton, Massachusetts, Mevion has established itself as a leader in the radiation therapy sector by creating innovative and effective solutions that enhance cancer care. The company, formerly known as Still River Systems, transitioned to its current name in 2011. Its flagship product, the MEVION S250 Proton Therapy System, aims to combine the advantages of traditional proton therapy with reduced size, cost, and complexity. This advancement enhances beam reliability and system uptime, making proton therapy more accessible and economically viable for cancer centers worldwide. Mevion operates internationally, with additional offices in the United Kingdom, China, and Japan, serving a global clientele.

Telormedix is a biopharmaceutical company dedicated to advancing targeted immunity through the modulation of the innate immune system for the treatment of cancer and autoimmune diseases. The company develops innovative biopharmaceutical drugs that aim to address both cancer and infectious diseases. Its drug formulations incorporate clinically active small molecule compounds known for their favorable safety profiles and specific immunotherapeutic targets. This approach enables Telormedix to offer advanced treatment options that enhance medical outcomes for cancer patients.

Immune Design Corp., a clinical-stage immunotherapy company based in Seattle, Washington, focuses on enabling the body's immune system to combat diseases, with a primary emphasis on cancer treatment. The company leverages its ZVex and GLAAS discovery platforms to develop innovative therapies. Its lead product candidate is G100, currently in Phase II clinical trials for treating follicular non-Hodgkin lymphoma, both as a monotherapy and in combination therapy. Immune Design has collaboration and license agreements with Sanofi Pasteur. The company was founded in 2008 and operates under the umbrella of Merck & Co., Inc.

ReVision Optics, Inc. is a company that specializes in designing, manufacturing, and delivering implantable products aimed at treating presbyopia, a condition associated with the natural aging process that affects near vision. The company's flagship product, the PRESBYLENS Corneal Inlay, offers a patented refractive surgery solution that enhances visual acuity for individuals experiencing age-related vision loss. Founded in 1996 and based in Lake Forest, California, ReVision Optics serves ophthalmology professionals, providing them with advanced technology to improve patient outcomes. Originally established as IntraLens Vision, Inc., the company rebranded to its current name in 2005, reflecting its focus on innovative optical solutions.

Mevion Medical Systems, Inc. is a company specializing in the development of proton therapy systems for cancer treatment. Founded in 2004 and headquartered in Littleton, Massachusetts, Mevion has established itself as a leader in the radiation therapy sector by creating innovative and effective solutions that enhance cancer care. The company, formerly known as Still River Systems, transitioned to its current name in 2011. Its flagship product, the MEVION S250 Proton Therapy System, aims to combine the advantages of traditional proton therapy with reduced size, cost, and complexity. This advancement enhances beam reliability and system uptime, making proton therapy more accessible and economically viable for cancer centers worldwide. Mevion operates internationally, with additional offices in the United Kingdom, China, and Japan, serving a global clientele.

ReVision Optics, Inc. is a company that specializes in designing, manufacturing, and delivering implantable products aimed at treating presbyopia, a condition associated with the natural aging process that affects near vision. The company's flagship product, the PRESBYLENS Corneal Inlay, offers a patented refractive surgery solution that enhances visual acuity for individuals experiencing age-related vision loss. Founded in 1996 and based in Lake Forest, California, ReVision Optics serves ophthalmology professionals, providing them with advanced technology to improve patient outcomes. Originally established as IntraLens Vision, Inc., the company rebranded to its current name in 2005, reflecting its focus on innovative optical solutions.

Mersana Therapeutics is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, focused on developing innovative antibody-drug conjugates (ADCs) for cancer patients with unmet medical needs. The company utilizes its proprietary Dolaflexin platform to create a pipeline of novel ADC candidates designed to improve treatment outcomes for those not responding to traditional therapies. Mersana's lead product candidate, XMT-1536, targets NaPi2b and is currently undergoing Phase I clinical trials for ovarian cancer, non-small cell lung cancer, and other orphan indications. In addition to XMT-1536, the company is advancing several early-stage programs, including XMT-1660, which targets B7-H4, and XMT-2056, a STING agonist ADC. Mersana has established strategic partnerships for research and development, notably with Merck KGaA and Asana BioSciences, to enhance its ADC product portfolio. Founded in 2005, Mersana Therapeutics continues to innovate in the field of oncology therapeutics.

Agile Therapeutics, Inc. is a women's healthcare company based in Princeton, New Jersey, dedicated to the research, development, and commercialization of prescription contraceptive products. The company's lead product is Twirla, a once-weekly transdermal contraceptive patch that combines levonorgestrel and ethinyl estradiol, designed to provide a non-daily option for contraception. Agile Therapeutics is also advancing a pipeline of additional products and extensions related to Twirla, including regimens aimed at offering women extended cycles, shorter and lighter periods, and a progestin-only patch for those who cannot or prefer not to use estrogen. Utilizing proprietary Skinfusion technology, the company aims to deliver effective contraceptive solutions that address the unmet health needs of women today. Founded in 1997, Agile Therapeutics continues to focus on innovating women's healthcare options.

Telormedix is a biopharmaceutical company dedicated to advancing targeted immunity through the modulation of the innate immune system for the treatment of cancer and autoimmune diseases. The company develops innovative biopharmaceutical drugs that aim to address both cancer and infectious diseases. Its drug formulations incorporate clinically active small molecule compounds known for their favorable safety profiles and specific immunotherapeutic targets. This approach enables Telormedix to offer advanced treatment options that enhance medical outcomes for cancer patients.

Mevion Medical Systems, Inc. is a company specializing in the development of proton therapy systems for cancer treatment. Founded in 2004 and headquartered in Littleton, Massachusetts, Mevion has established itself as a leader in the radiation therapy sector by creating innovative and effective solutions that enhance cancer care. The company, formerly known as Still River Systems, transitioned to its current name in 2011. Its flagship product, the MEVION S250 Proton Therapy System, aims to combine the advantages of traditional proton therapy with reduced size, cost, and complexity. This advancement enhances beam reliability and system uptime, making proton therapy more accessible and economically viable for cancer centers worldwide. Mevion operates internationally, with additional offices in the United Kingdom, China, and Japan, serving a global clientele.

MethylGene Inc. (TSX:MYG) is a publicly-traded, clinical stage biopharmaceutical company focused on the development and commercialization of novel therapeutics with a focus on cancer. The Company's product candidates include: MGCD265, an oral, multi-targeted kinase inhibitor targeting the Met, VEGF, Ron and Tie-2 receptor tyrosine kinases that is in multiple clinical trials for cancer; MGCD290, a fungal Hos2 inhibitor for use in combination with fluconazole for serious fungal infections which has completed Phase I clinical studies; and mocetinostat (MGCD0103), an oral, isoform-selective HDAC inhibitor for cancer which has been in multiple Phase II clinical trials and is currently in a Phase II trial in refractory or relapsed follicular lymphoma. Mocetinostat is licensed to Taiho Pharmaceutical Co. Ltd in certain Asian countries. A fourth compound discovered using MethylGene's HDAC platform, EVP-0334 - a potential cognition enhancing agent for neurodegenerative diseases has successfully completed Phase I trials sponsored by EnVivo Pharmaceuticals Inc. MethylGene also has a funded collaboration with Otsuka Pharmaceutical Co. Ltd. for applications in ocular diseases using the Company's proprietary kinase inhibitor chemistry.

Aires Pharmaceuticals, Inc. is a clinical stage pharmaceutical company based in San Diego, California, specializing in the development of therapies for pulmonary disorders. Founded in 2006, the company is focused on creating innovative treatments for conditions such as pulmonary arterial hypertension, pulmonary hypertension due to heart failure, and bacterial pulmonary infections. One of its key products, Aironite, is an inhaled medication designed for both adult and pediatric patients suffering from pulmonary hypertension, cystic fibrosis, pneumonia, and other respiratory infections. Through its research and development efforts, Aires Pharmaceuticals aims to address unmet medical needs in the field of pulmonary health.

Immune Design Corp., a clinical-stage immunotherapy company based in Seattle, Washington, focuses on enabling the body's immune system to combat diseases, with a primary emphasis on cancer treatment. The company leverages its ZVex and GLAAS discovery platforms to develop innovative therapies. Its lead product candidate is G100, currently in Phase II clinical trials for treating follicular non-Hodgkin lymphoma, both as a monotherapy and in combination therapy. Immune Design has collaboration and license agreements with Sanofi Pasteur. The company was founded in 2008 and operates under the umbrella of Merck & Co., Inc.

ReVision Optics, Inc. is a company that specializes in designing, manufacturing, and delivering implantable products aimed at treating presbyopia, a condition associated with the natural aging process that affects near vision. The company's flagship product, the PRESBYLENS Corneal Inlay, offers a patented refractive surgery solution that enhances visual acuity for individuals experiencing age-related vision loss. Founded in 1996 and based in Lake Forest, California, ReVision Optics serves ophthalmology professionals, providing them with advanced technology to improve patient outcomes. Originally established as IntraLens Vision, Inc., the company rebranded to its current name in 2005, reflecting its focus on innovative optical solutions.

Predictive Biosciences, Inc. is a molecular diagnostics company focused on developing diagnostic products aimed at enhancing cancer management. Founded in 2006 and headquartered in Lexington, Massachusetts, the company specializes in proteomics and oncology, particularly in the area of tumor biomarkers. Predictive Biosciences offers a range of assays that detect urinary biomarkers, which are indicative of the physiological changes associated with cancer development and progression. Among its key products are the Triage Monitoring Assay, which enables physicians to postpone invasive diagnostic procedures, the Interval Monitoring Assay for cancer surveillance between follow-up appointments, and the Stratification Assay to assist physicians in managing patient care decisions.

Agile Therapeutics, Inc. is a women's healthcare company based in Princeton, New Jersey, dedicated to the research, development, and commercialization of prescription contraceptive products. The company's lead product is Twirla, a once-weekly transdermal contraceptive patch that combines levonorgestrel and ethinyl estradiol, designed to provide a non-daily option for contraception. Agile Therapeutics is also advancing a pipeline of additional products and extensions related to Twirla, including regimens aimed at offering women extended cycles, shorter and lighter periods, and a progestin-only patch for those who cannot or prefer not to use estrogen. Utilizing proprietary Skinfusion technology, the company aims to deliver effective contraceptive solutions that address the unmet health needs of women today. Founded in 1997, Agile Therapeutics continues to focus on innovating women's healthcare options.

Adastra Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company based in San Diego, California, that specializes in developing innovative treatments for cancer. Founded in 2005 and previously known as Tragara Pharmaceuticals, the company is focused on creating proprietary medicines aimed at improving patient care in oncology. Among its key products is an oral multi-kinase inhibitor designed to inhibit critical cyclin-dependent kinases, which may enhance patient survival rates and overall quality of life. Adastra Pharmaceuticals is dedicated to advancing its portfolio of cancer therapies to meet the needs of healthcare professionals and patients alike.

ORTHOCON is a medical therapeutics company focused on developing innovative absorbable products specifically for orthopedic and spine surgeries. The company specializes in creating implantable products that effectively address bone bleeding, which is a common challenge in surgical procedures. Among its offerings is the HEMASORB Absorbable Bone Hemostat Matrix, a ready-to-use, biocompatible, water-resistant, and absorbable putty designed to halt bleeding when applied to damaged or cut bone. ORTHOCON's commitment to enhancing surgical outcomes is reflected in its development and manufacturing processes aimed at providing effective solutions for healthcare professionals in the field of orthopedics.

Gloucester Pharmaceuticals is a biopharmaceutical company focused on developing and advancing clinical-stage oncology drug candidates. Owned by Celgene, the company specializes in hematological malignancies and is best known for its lead compound, romidepsin. This late-stage oncology drug is a histone deacetylase (HDAC) inhibitor that has demonstrated potential efficacy in treating various forms of T-cell lymphomas and other hematological cancers, including cutaneous T-cell lymphoma, peripheral T-cell lymphoma, and multiple myeloma. Gloucester Pharmaceuticals retains worldwide exclusive rights to romidepsin, which has shown promise as a potent inhibitor of multiple HDAC classes in preclinical studies. The company aims to progress its drug candidates through regulatory approval and commercialization to address unmet medical needs in oncology.

Biosyntech is a Canadian biotechnology company based in Laval, incorporated in 1994. It specializes in developing biotherapeutic thermogels for tissue repair and therapeutic agent delivery. The company's technology platform, BST-Gel, utilizes chitosan, a natural biopolymer derived from crustacean shells, to create hydrogels. Biosyntech's lead products include BST-CarGel for cartilage repair, BST-DermOn for wound healing, and BST-InPod for treating chronic pain due to plantar fat pad atrophy in the heel and forefoot. The company has collaborated with Nicholas Piramal India Ltd. on clinical studies for BST-InPod. Additionally, Biosyntech develops products like BST-Ossifil, BST-Ossifix, and BST-Disc for bone repair and intervertebral disc restoration.

Zosano Pharma Corporation, established in 2006 and based in Fremont, California, is a clinical-stage biopharmaceutical company specializing in innovative drug delivery systems. The company focuses on developing therapeutics for large unmet medical needs, with a primary focus on treating migraine patients using its proprietary intracutaneous microneedle system. Zosano's lead product candidate, Qtrypta (M207), is a rapid-acting formulation of zolmitriptan designed to provide swift relief from migraine symptoms via this novel delivery method.

Clovis Oncology, Inc. is a biopharmaceutical company dedicated to acquiring, developing, and commercializing innovative cancer treatments in the United States, Europe, and other international markets. The company focuses on precision medicine, targeting specific cancer subsets to ensure that therapeutics are directed to patients who are most likely to benefit. Clovis Oncology's primary product is Rubraca, an oral small molecule inhibitor of poly ADP-ribose polymerase, approved for the treatment of recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer. Additionally, the company is developing lucitanib, an oral inhibitor targeting multiple tyrosine kinase receptors involved in cancer progression. Clovis distributes its products through specialty distributors and pharmacy providers, and it engages in various collaborations and licensing agreements with prominent pharmaceutical companies such as Pfizer, AstraZeneca, and Bristol-Myers Squibb. Founded in 2009 and headquartered in Boulder, Colorado, Clovis Oncology is committed to advancing cancer care through targeted therapeutic approaches.

ORTHOCON is a medical therapeutics company focused on developing innovative absorbable products specifically for orthopedic and spine surgeries. The company specializes in creating implantable products that effectively address bone bleeding, which is a common challenge in surgical procedures. Among its offerings is the HEMASORB Absorbable Bone Hemostat Matrix, a ready-to-use, biocompatible, water-resistant, and absorbable putty designed to halt bleeding when applied to damaged or cut bone. ORTHOCON's commitment to enhancing surgical outcomes is reflected in its development and manufacturing processes aimed at providing effective solutions for healthcare professionals in the field of orthopedics.

Aerovance is a privately held biopharmaceutical company exclusively focused on developing and commercializing breakthrough medicines for respiratory and allergic diseases. The company maintains a solid intellectual property position with its strong portfolio of novel therapeutic candidates now in clinical development and several pre-clinical programs. The two lead products are human recombinant proteins: Aerovantâ„¢, an IL-4 and -13 receptor antagonist which is in Phase IIa studies for asthma and Aerodermâ„¢, a PEGylated IL-4 and IL-13 receptor antagonist in pre-clinical studies for eczema.

Telormedix is a biopharmaceutical company dedicated to advancing targeted immunity through the modulation of the innate immune system for the treatment of cancer and autoimmune diseases. The company develops innovative biopharmaceutical drugs that aim to address both cancer and infectious diseases. Its drug formulations incorporate clinically active small molecule compounds known for their favorable safety profiles and specific immunotherapeutic targets. This approach enables Telormedix to offer advanced treatment options that enhance medical outcomes for cancer patients.

Gemin X Pharmaceuticals is focused on the discovery, development, and commercialization of innovative cancer therapeutics aimed at improving patient outcomes. The company’s research centers on the Bcl-2 cell death regulation pathway, leading to the development of GX15-070, also known as obatoclax. This small molecule is designed to selectively trigger programmed cell death, or apoptosis, and may also promote autophagy in cancer cells. Obatoclax has demonstrated encouraging results in preclinical and early clinical studies and is currently undergoing Phase 2 clinical trials, both as a standalone treatment and in combination therapies. In addition to obatoclax, Gemin X is developing GMX1777, an inhibitor of NAD+ synthesis, among other oncology products, providing patients with potential relief from various cancer conditions. The company holds patent protection for obatoclax until 2025.

Sopherion Therapeutics, LLC is a privately held biopharmaceutical company based in Princeton, New Jersey, with additional offices in Cheshire, Connecticut, and Estero, Florida, as well as a subsidiary in Toronto, Canada. The company specializes in the development and commercialization of oncology therapies, notably Myocet™, a liposome-encapsulated doxorubicin-citrate complex designed to reduce cardiotoxicity. Sopherion holds an exclusive licensing agreement with Cephalon, Inc. for Myocet™ in the United States and Canada. The firm is currently conducting a Phase III global trial to evaluate Myocet™ in combination with Herceptin® and Taxol for treating invasive, metastatic breast cancer. This trial, which aims to recruit 363 patients across twelve countries, builds on promising Phase II results that demonstrated a 96% response rate and a median progression-free survival of two and a half years. Myocet™ is already registered for use in Canada and Europe in combination with cyclophosphamide for similar indications. Sopherion is also exploring additional oncology agents through its Minicell Peptide Display screening technologies.

Excaliard Pharmaceuticals is a biotechnology company focused on developing and commercializing antisense drugs specifically for the local treatment of scarring and other fibrotic diseases. By creating targeted therapeutics, the company aims to address dermatological disorders and provide patients with enhanced treatment options for conditions related to fibrosis. With a commitment to advancing medical care in this area, Excaliard is positioned to make significant contributions to the field of dermatology.

Zosano Pharma Corporation, established in 2006 and based in Fremont, California, is a clinical-stage biopharmaceutical company specializing in innovative drug delivery systems. The company focuses on developing therapeutics for large unmet medical needs, with a primary focus on treating migraine patients using its proprietary intracutaneous microneedle system. Zosano's lead product candidate, Qtrypta (M207), is a rapid-acting formulation of zolmitriptan designed to provide swift relief from migraine symptoms via this novel delivery method.

LEAD Therapeutics, Inc. is a chemistry-driven drug discovery company focused on delivering novel and differentiated small molecule IND candidates against clinically validated therapeutic targets, focused primarily on the treatment of Cancer and infectious diseases.

5asec is a textile care brand that provides its customers with dry cleaning and laundry services. 5asec provides its services in 3 segments, including basic services: dry cleaning, professional washing and steam ironing, and stain cleaning; professional services: duvet and home linen treatment, alterations services; and carpets, furniture, and leather cleaning; and textile care solutions: maxima treatment, appret finish, anti-moth and dust mites’ repellent solutions, and water repellent treatments. 5asec is headquartered in Geneva, Switzerland.

Adastra Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company based in San Diego, California, that specializes in developing innovative treatments for cancer. Founded in 2005 and previously known as Tragara Pharmaceuticals, the company is focused on creating proprietary medicines aimed at improving patient care in oncology. Among its key products is an oral multi-kinase inhibitor designed to inhibit critical cyclin-dependent kinases, which may enhance patient survival rates and overall quality of life. Adastra Pharmaceuticals is dedicated to advancing its portfolio of cancer therapies to meet the needs of healthcare professionals and patients alike.

Alaunos Therapeutics is a clinical-stage biotechnology company focused on developing innovative therapies for the treatment of solid tumors, particularly through adoptive TCR-T cell therapy. Utilizing a unique gene expression and control technology, the company aims to engineer cell therapies that specifically target neoantigens resulting from genomic mutations in cancer cells. This approach is designed to enhance the precision and efficacy of cancer treatments by modulating gene expression directly at the tumor site. Currently, Alaunos is evaluating its technology in Phase 2 clinical studies, including the use of the immune system cytokine interleukin-12 for breast cancer and advanced melanoma. The company is also actively pursuing new investigational drug applications for additional targets using its advanced therapeutic platforms.

NovaDel Pharma Inc. is a specialty pharmaceutical company engaged in the development of novel drug delivery systems for prescription and over-the-counter drugs. The Company's proprietary oral spray technology delivery system offers the patient the potential for (i) more rapid delivery of drugs to the bloodstream allowing for quicker onset of therapeutic effects compared to conventional oral dosage forms; (ii) increased bioavailability of a drug by avoiding metabolism by the liver; (iii) improved drug safety profile by reducing the required dosage, including possible reduction of side effects; (iv) improved dosage reliability; (v) allowing medication to be taken without water; (vi) avoiding the need to swallow as is the case with many medications; and (vii) improved patient convenience and compliance. The Company plans to develop such products independently and through collaborative arrangements with major pharmaceutical and biotech companies.

Cabrellis Pharmaceuticals Corporation, a specialty pharmaceutical company developing therapies for the treatment of cancer. Cabrellis plans to initiate three separate clinical trials in small cell lung cancer (SCLC) in 2006. The first trial, designed to assess the safety and efficacy of Calsed(TM) in reference to topotecan in the second-line treatment of patients with SCLC who previously responded to platinum-based chemotherapy, is currently underway at multiple clinical trial sites in the United States.

Alaunos Therapeutics is a clinical-stage biotechnology company focused on developing innovative therapies for the treatment of solid tumors, particularly through adoptive TCR-T cell therapy. Utilizing a unique gene expression and control technology, the company aims to engineer cell therapies that specifically target neoantigens resulting from genomic mutations in cancer cells. This approach is designed to enhance the precision and efficacy of cancer treatments by modulating gene expression directly at the tumor site. Currently, Alaunos is evaluating its technology in Phase 2 clinical studies, including the use of the immune system cytokine interleukin-12 for breast cancer and advanced melanoma. The company is also actively pursuing new investigational drug applications for additional targets using its advanced therapeutic platforms.

Optimer Pharmaceuticals, Inc. is a biopharmaceutical company dedicated to the discovery, development, and commercialization of anti-infective products. The company primarily focuses on addressing gastrointestinal infections and related diseases that have limited treatment options. Its notable late-stage product candidates include fidaxomicin, an antibacterial drug designed for the treatment of Clostridium difficile-associated diarrhea, and Pruvel (prulifloxacin). In addition to these, Optimer's portfolio comprises CEM-101, OPT-822/OPT-821 combination therapy, and OPT-88. The company aims to create therapies that significantly improve patient outcomes and alleviate the burden of infectious diseases.

Mersana Therapeutics is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, focused on developing innovative antibody-drug conjugates (ADCs) for cancer patients with unmet medical needs. The company utilizes its proprietary Dolaflexin platform to create a pipeline of novel ADC candidates designed to improve treatment outcomes for those not responding to traditional therapies. Mersana's lead product candidate, XMT-1536, targets NaPi2b and is currently undergoing Phase I clinical trials for ovarian cancer, non-small cell lung cancer, and other orphan indications. In addition to XMT-1536, the company is advancing several early-stage programs, including XMT-1660, which targets B7-H4, and XMT-2056, a STING agonist ADC. Mersana has established strategic partnerships for research and development, notably with Merck KGaA and Asana BioSciences, to enhance its ADC product portfolio. Founded in 2005, Mersana Therapeutics continues to innovate in the field of oncology therapeutics.

Guava Technologies, Inc. is a biotechnology and medical device manufacturer based in Hayward, California. Founded in 1998, the company specializes in the development, design, and manufacturing of products used primarily in cell biology research and clinical diagnostics. Its offerings include a range of assays for monitoring HIV/AIDS, cell counting, antibody quantification, cytotoxicity, and apoptosis, as well as benchtop cell analysis systems. Guava Technologies also produces flow cytometry systems tailored for various applications in life science research and drug discovery. As of 2009, Guava Technologies operates as a subsidiary of Millipore Corp.

EUSA Pharma, founded in March 2006 and headquartered in the UK, is a profitable specialty pharmaceutical company that operates globally with a focus on oncology and other critical diseases. The company markets a portfolio of five approved specialty hospital products, including Caphosol®, Xenazine®, Collatamp®, Custodiol®, and Fomepizole®, along with several named-patient products. EUSA Pharma is dedicated to addressing rare diseases and conditions such as oral mucositis, a common side effect of cancer treatments. The company has submitted a Marketing Authorization Application for FOTIVDA (tivozanib HCL) as a first-line therapy for renal cell carcinoma. With plans to expand its portfolio through acquisitions and in-licensing, EUSA Pharma's operations extend across Europe and the USA, supported by a network of commercial partners in Europe, the Middle East, Asia, and Latin America, making its products available in approximately 40 countries worldwide. The company is led by an experienced management team with a strong track record in the specialty pharmaceutical sector.

Gloucester Pharmaceuticals is a biopharmaceutical company focused on developing and advancing clinical-stage oncology drug candidates. Owned by Celgene, the company specializes in hematological malignancies and is best known for its lead compound, romidepsin. This late-stage oncology drug is a histone deacetylase (HDAC) inhibitor that has demonstrated potential efficacy in treating various forms of T-cell lymphomas and other hematological cancers, including cutaneous T-cell lymphoma, peripheral T-cell lymphoma, and multiple myeloma. Gloucester Pharmaceuticals retains worldwide exclusive rights to romidepsin, which has shown promise as a potent inhibitor of multiple HDAC classes in preclinical studies. The company aims to progress its drug candidates through regulatory approval and commercialization to address unmet medical needs in oncology.

BioRexis has developed proprietary protein engineering technologies based upon human transferrin that provide novel therapeutic agents with longer duration of action than synthetic peptides. In addition to reducing dosing frequency, these technologies have the potential to substantially improve patient tolerability. This new platform supports Pfizer’s commitment to develop novel protein therapeutic agents.

Threshold is a biotechnology company focused on the discovery and development of drugs targeting Tumor Hypoxia, the low oxygen condition found in microenvironments of most solid tumors. This approach offers broad potential to treat most solid tumors. By selectively targeting tumor cells, they are building a pipeline of drugs that hold promise to be more effective and less toxic to healthy tissues than conventional anticancer drugs.

As of January 30, 2009, Novacea, Inc. was acquired by Transcept Pharmaceuticals, Inc., in a reverse merger transaction. Novacea, Inc., a biopharmaceutical company, focuses on in-licensing, developing, and commercializing therapies for the treatment of cancer. The company’s product candidates include Asentar, which is in Phase III clinical trial for the treatment of androgen-independent prostate cancer and in Phase II clinical trial for the treatment of advanced pancreatic cancer; and AQ4N, a hypoxia-activated prodrug in Phase Ib/IIa clinical trial for the treatment of glioblastoma multiforme. It has license and collaboration agreements with Aventis Pharmaceuticals, Inc.; Oregon Health & Science University; University of Pittsburgh; KuDOS Pharmaceuticals Limited; and BTG International Limited. The company was founded in 2001 and is headquartered in South San Francisco, California.

Conforma Therapeutics Corporation designs and develops drugs for the treatment of cancer. It develops drugs that induce tumor cells to degrade the proteins that promote cancer growth. The company offers HSP90 and CNF1010 which are used for the treatment of cancer. The company was incorporated in 1999 and is based in San Diego, California

Sopherion Therapeutics, LLC is a privately held biopharmaceutical company based in Princeton, New Jersey, with additional offices in Cheshire, Connecticut, and Estero, Florida, as well as a subsidiary in Toronto, Canada. The company specializes in the development and commercialization of oncology therapies, notably Myocet™, a liposome-encapsulated doxorubicin-citrate complex designed to reduce cardiotoxicity. Sopherion holds an exclusive licensing agreement with Cephalon, Inc. for Myocet™ in the United States and Canada. The firm is currently conducting a Phase III global trial to evaluate Myocet™ in combination with Herceptin® and Taxol for treating invasive, metastatic breast cancer. This trial, which aims to recruit 363 patients across twelve countries, builds on promising Phase II results that demonstrated a 96% response rate and a median progression-free survival of two and a half years. Myocet™ is already registered for use in Canada and Europe in combination with cyclophosphamide for similar indications. Sopherion is also exploring additional oncology agents through its Minicell Peptide Display screening technologies.

Iomai Corporation, established in 1997 and headquartered in Gaithersburg, Maryland, specializes in the discovery and development of vaccines and immune system stimulants. The company's unique approach involves a needle-free delivery method known as transcutaneous immunization (TCI), which harnesses the skin's antigen-presenting cells to generate an enhanced immune response. Iomai leverages this technology to improve existing vaccines, enable new ones, and expand global vaccine accessibility. Following its acquisition by Intercell AG in 2008, Iomai operates as a subsidiary under the name Intercell USA Inc.

BioRexis has developed proprietary protein engineering technologies based upon human transferrin that provide novel therapeutic agents with longer duration of action than synthetic peptides. In addition to reducing dosing frequency, these technologies have the potential to substantially improve patient tolerability. This new platform supports Pfizer’s commitment to develop novel protein therapeutic agents.

As of January 30, 2009, Novacea, Inc. was acquired by Transcept Pharmaceuticals, Inc., in a reverse merger transaction. Novacea, Inc., a biopharmaceutical company, focuses on in-licensing, developing, and commercializing therapies for the treatment of cancer. The company’s product candidates include Asentar, which is in Phase III clinical trial for the treatment of androgen-independent prostate cancer and in Phase II clinical trial for the treatment of advanced pancreatic cancer; and AQ4N, a hypoxia-activated prodrug in Phase Ib/IIa clinical trial for the treatment of glioblastoma multiforme. It has license and collaboration agreements with Aventis Pharmaceuticals, Inc.; Oregon Health & Science University; University of Pittsburgh; KuDOS Pharmaceuticals Limited; and BTG International Limited. The company was founded in 2001 and is headquartered in South San Francisco, California.

Pharmion is a global biotech company that is dedicated to the hematology and oncology communities. We work in partnership with a network of scientific and clinical advisors to identify and develop products for global hematology and oncology markets. To expand each product's potential, we have established our own regulatory, development and sales and marketing organizations in the United States, Europe, and Australia, and we have developed a third-party distributor network to serve the hematology and oncology markets in 20 additional countries throughout the Middle East, Asia, and Latin America. The global capabilities within our sales, marketing and distribution organization distinguishes us from other companies of a similar size. With our international network we can reach physicians and their patients in more than 30 countries. With proven development and regulatory professionals and an experienced global commercialization team, we concentrate our resources on licensing, developing, and commercializing therapeutic products for the treatment of hematology and oncology patients. Through these efforts, we seek to provide greater therapeutic options to hematologists and oncologists with the ultimate goal of extending survival and improving patients’ quality of life.

Threshold is a biotechnology company focused on the discovery and development of drugs targeting Tumor Hypoxia, the low oxygen condition found in microenvironments of most solid tumors. This approach offers broad potential to treat most solid tumors. By selectively targeting tumor cells, they are building a pipeline of drugs that hold promise to be more effective and less toxic to healthy tissues than conventional anticancer drugs.

Salmedix is an oncology drug development company with a commercial focus on the treatment of hematologic malignancies, or blood cancers. Its primary product, SDX-105, is marketed by healthcare professionals in Germany for the treatment of several types of blood cancers. Salmedix conducts Phase II clinical trials for SDX-105 in the U.S. and Canada. Its other clinical-stage product candidates, SDX-101 and SDX-102, each with significant prior human clinical experience, are also in Phase II development. Founded in 2000 by David Kabakoff, Salmedix is headquartered in San Diego, California.

Optimer Pharmaceuticals, Inc. is a biopharmaceutical company dedicated to the discovery, development, and commercialization of anti-infective products. The company primarily focuses on addressing gastrointestinal infections and related diseases that have limited treatment options. Its notable late-stage product candidates include fidaxomicin, an antibacterial drug designed for the treatment of Clostridium difficile-associated diarrhea, and Pruvel (prulifloxacin). In addition to these, Optimer's portfolio comprises CEM-101, OPT-822/OPT-821 combination therapy, and OPT-88. The company aims to create therapies that significantly improve patient outcomes and alleviate the burden of infectious diseases.

Guava Technologies, Inc. is a biotechnology and medical device manufacturer based in Hayward, California. Founded in 1998, the company specializes in the development, design, and manufacturing of products used primarily in cell biology research and clinical diagnostics. Its offerings include a range of assays for monitoring HIV/AIDS, cell counting, antibody quantification, cytotoxicity, and apoptosis, as well as benchtop cell analysis systems. Guava Technologies also produces flow cytometry systems tailored for various applications in life science research and drug discovery. As of 2009, Guava Technologies operates as a subsidiary of Millipore Corp.

Acurian provides solutions needed to recruit, enroll, and retain patients for clinical trials. The company offers recruitment feasibility, site identification and selection, patient recruitment and retention, and cancer solutions. Acurian was founded in 1998 and is based in Horsham, Pennsylvania.