Spruce Capital Partners

Spruce Capital Partners is a venture capital firm based in San Francisco, California, founded in 2013. It specializes in the life sciences sector, with a strong focus on biogreentech. The firm's principals are seasoned investors and thought leaders who possess extensive experience in guiding entrepreneurs towards building successful biogreentech companies. In addition to managing venture funds, Spruce Capital Partners is dedicated to fostering new talent in the industry, providing thought leadership, and promoting innovation on a global scale, particularly in regions such as Malaysia and the United States. The team has collaborated for over a decade, leveraging their collective expertise to influence the development of the life sciences industry.

Roger Wyse

Managing Partner and Co-Founder

17 past transactions

A.Team

Series A in 2022
A.Team is a professional network for A-Talent to connect and form full-stack teams. It is powered by an invite-only professional network of top independent product builders. Its aim is to help companies keep up and thrive during today’s digital disruptions. A.Team was designed to help companies adapt agilely and build tech in areas outside of their core competencies—to pivot their product and adapt new methods of monetization.
GreenLight Biosciences is an integrated life sciences company with a cutting-edge platform to deliver higher-quality RNA at a lower cost and more quickly than was ever before possible. GreenLight develops RNA products and collaborates with industry leaders to advance vaccine development, pandemic preparation, crop management, plant protection and support the health of bees and other pollinators.

Amfora

Series B in 2021
Amfora is a biotechnology company that is harnessing biology to sustainably nourish the world’s population and enhancing wellness. Amfora's mission is to meet the growing global demand for foods that are high in protein by enhancing the nutritional density of food and feed crops, while reducing the cost of food and the environmental toll on the planet.

Provivi

Series C in 2020
Provivi is developing biopesticides for agriculture, commercial, household, and public health pest management. It has a world-class team of founders, scientists, and advisors with significant experience in biotechnology (including biocatalysis), the fine chemicals industry, and, in particular, the agchem industry. It pursues disruptive opportunities enabled by breakthrough biological processes for making supply-limited products that are efficacious, safe, and environmentally benign. Provivi was founded in 2013 based on biocatalysis technology developed at the California Institute of Technology (Caltech) which has since become a licensor, shareholder, and research collaborator. It is based in Santa Monica, California.

GreenLight Biosciences

Series D in 2020
GreenLight Biosciences is an integrated life sciences company with a cutting-edge platform to deliver higher-quality RNA at a lower cost and more quickly than was ever before possible. GreenLight develops RNA products and collaborates with industry leaders to advance vaccine development, pandemic preparation, crop management, plant protection and support the health of bees and other pollinators.

Pivot Bio

Series C in 2020
Pivot Bio is improving and using a deep understanding of the microbiome to advance crop nutrition. They believe that microbes can deliver nutrients, protect against pests, and improve crop quality better than chemical fertilizers and pesticides. They leverage engineering principles and data science to map the dynamics of the plant microbiome and evolve beneficial traits. Their team thrives on collaboration and communication as they seek to create revolutionary fertilizers that transform food supply and improves the planet. Pivot Bio's proprietary ON Technology harnesses the power of naturally occurring microbes to provide more nutrients to crops. It’s a smart, sustainable way for farmers to improve yield as they work to help feed the world’s growing population. Their current efforts are focused on enabling microbes to fix and supply more nitrogen to corn. Pivot Bio was founded in 2010 and is headquartered in Berkeley, California, United States.

Crop Enhancement

Series B in 2020
Crop Enhancement develop a new approach that will help farmers increase crop yields and profitability in a sustainable way. By developing agrochemical formulations that employ advanced and environmentally friendly chemistry, we help improve crop yields, eliminate or minimize pesticide use, and enable precise and effective delivery of active ingredients and fertilizers.

Provivi

Series C in 2019
Provivi is developing biopesticides for agriculture, commercial, household, and public health pest management. It has a world-class team of founders, scientists, and advisors with significant experience in biotechnology (including biocatalysis), the fine chemicals industry, and, in particular, the agchem industry. It pursues disruptive opportunities enabled by breakthrough biological processes for making supply-limited products that are efficacious, safe, and environmentally benign. Provivi was founded in 2013 based on biocatalysis technology developed at the California Institute of Technology (Caltech) which has since become a licensor, shareholder, and research collaborator. It is based in Santa Monica, California.

Consumer Physics

Venture Round in 2018
Consumer Physics is driven by a mission to empower consumers and businesses to learn about the makeup of materials anytime, anywhere by using SCiO, the smallest near-infrared (NIR) spectrometer. The SCiO sensor pairs with SCiO smartphone apps and connects to a cloud-based database of material fingerprints. Consumer Physics offers businesses and 3rd party developers a platform that enables them to design their own molecular sensing models and mobile applications for personal and commercial use. The SCiO DevKit includes the SCiO Lab development platform and Mobile SDK and access to professional support from Consumer Physics experts.

Inscripta

Series C in 2018
Inscripta is developing the first benchtop platform for scalable digital genome engineering. The company’s advanced CRISPR-based platform, consisting of an instrument, consumables, software, and assays, offers a fully automated workflow that enables massively parallel, trackable editing of single cells at an unprecedented scale. Inscripta’s goal is to empower scientists whose gene editing research is stifled by current technical and licensing limitations. By providing this unique platform and engaging in collaborative business practices, such as making its MAD7 CRISPR nuclease-free for research and development purposes, the company enables scientists to realize a new era of biological discovery.

Provivi

Series B in 2017
Provivi is developing biopesticides for agriculture, commercial, household, and public health pest management. It has a world-class team of founders, scientists, and advisors with significant experience in biotechnology (including biocatalysis), the fine chemicals industry, and, in particular, the agchem industry. It pursues disruptive opportunities enabled by breakthrough biological processes for making supply-limited products that are efficacious, safe, and environmentally benign. Provivi was founded in 2013 based on biocatalysis technology developed at the California Institute of Technology (Caltech) which has since become a licensor, shareholder, and research collaborator. It is based in Santa Monica, California.

Consumer Physics

Series C in 2017
Consumer Physics is driven by a mission to empower consumers and businesses to learn about the makeup of materials anytime, anywhere by using SCiO, the smallest near-infrared (NIR) spectrometer. The SCiO sensor pairs with SCiO smartphone apps and connects to a cloud-based database of material fingerprints. Consumer Physics offers businesses and 3rd party developers a platform that enables them to design their own molecular sensing models and mobile applications for personal and commercial use. The SCiO DevKit includes the SCiO Lab development platform and Mobile SDK and access to professional support from Consumer Physics experts.

Evolve Biosystems

Series B in 2017
Evolve Biosystems is a biotechnology company that specializes in providing microbiome-based products designed to develop, restore, and maintain. The company's platform focuses on solving the gut dysbiosis throughout the human life cycle as well as in various animal species, enabling physicians to maintain the healthy gut microbiome in newborn infants with a consumer-directed home use product, and a hospital-based neonatal ICU product.

Amfora

Series A in 2017
Amfora is a biotechnology company that is harnessing biology to sustainably nourish the world’s population and enhancing wellness. Amfora's mission is to meet the growing global demand for foods that are high in protein by enhancing the nutritional density of food and feed crops, while reducing the cost of food and the environmental toll on the planet.

Inscripta

Series B in 2017
Inscripta is developing the first benchtop platform for scalable digital genome engineering. The company’s advanced CRISPR-based platform, consisting of an instrument, consumables, software, and assays, offers a fully automated workflow that enables massively parallel, trackable editing of single cells at an unprecedented scale. Inscripta’s goal is to empower scientists whose gene editing research is stifled by current technical and licensing limitations. By providing this unique platform and engaging in collaborative business practices, such as making its MAD7 CRISPR nuclease-free for research and development purposes, the company enables scientists to realize a new era of biological discovery.

Agerpoint

Series B in 2016
Agerpoint® is an innovator in geospatial intelligence and data engineering that develops technologies to digitize, analyze and comprehend natural environments. Through a combination of artificial intelligence, high performance computing, computer vision and advanced analytics, the Agerpoint platform fuses together sensor from mobile devices, ground vehicles, autonomous robots, drones and satellites with other information and human observations to create a highly precise, quantifiable and interactive digital record to enable better decision-making for clients across agrochemical and food and beverage R&D, forestry, production agriculture, government and conservation organizations. With these advancements, our mission is to improve quality of life for our planet’s inhabitants and mitigate climate change by enabling a transformational shift in how we understand plants, crops and forests along with vegetation that coexists within built environments. Agerpoint was founded in 2012 and is headquartered in Research Triangle Park, North Carolina, USA.

Gevo

Series D in 2010
Gevo brings renewable and cost-effective fossil fuel alternatives to consumers worldwide will be absolutely essential to meet increasing energy demands and save their earth from global warming. Gevo focuses on the production of isobutanol.
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