Spruce Capital Partners

Spruce Capital Partners is a venture capital firm based in San Francisco, California, founded in 2013. It specializes in the life sciences sector, with a strong focus on biogreentech. The firm's principals are seasoned investors and thought leaders who possess extensive experience in guiding entrepreneurs towards building successful biogreentech companies. In addition to managing venture funds, Spruce Capital Partners is dedicated to fostering new talent in the industry, providing thought leadership, and promoting innovation on a global scale, particularly in regions such as Malaysia and the United States. The team has collaborated for over a decade, leveraging their collective expertise to influence the development of the life sciences industry.

Ganesh Kishore Ph.D

Co-Founder and Managing Partner

Roger Wyse Ph.D

Co-Founder and Managing Partner

17 past transactions

A.Team

Series A in 2022
A.Team is an invite-only professional network connecting top independent product builders. It enables companies to swiftly form full-stack teams for projects outside their core competencies, facilitating adaptation to digital disruptions and new monetization methods.

GreenLight Biosciences

Post in 2022
GreenLight Biosciences is a biotechnology company specializing in RNA-based solutions for agriculture and pharmaceutical applications. It develops mRNA vaccines, including COVID-19 candidates, and offers sustainable crop protection technologies using its proprietary cell-free production platform.

Amfora

Series B in 2021
Founded in 2016, Amfora is a biotechnology company based in San Francisco. It harnesses biology to sustainably enhance the nutritional density of food and feed crops, particularly focusing on increasing protein content through gene editing. The company aims to meet global demand for high-protein foods while reducing environmental impact.

Provivi

Series C in 2020
Provivi Inc. is a biotechnology company based in Santa Monica, California, focused on the development of biopesticides for agricultural, commercial, household, and public health pest management. Founded in 2013, the company leverages biocatalysis technology, originally developed at the California Institute of Technology, to create insect pheromones that protect food supplies without toxic residues. Provivi aims to provide effective and environmentally friendly crop protection solutions, fostering sustainable agricultural practices. Its innovative approach targets the synthesis of biopesticides through advanced processes, allowing for the efficient production of safe and affordable pest management products. The company distributes its offerings worldwide, seeking to transform pest control with its groundbreaking biological solutions.

GreenLight Biosciences

Series D in 2020
GreenLight Biosciences is a biotechnology company specializing in RNA-based solutions for agriculture and pharmaceutical applications. It develops mRNA vaccines, including COVID-19 candidates, and offers sustainable crop protection technologies using its proprietary cell-free production platform.

Pivot Bio

Series C in 2020
Founded in 2010, Pivot Bio is a biotechnology company specializing in microbial nitrogen fertilizers. It harnesses naturally occurring microbes to provide nutrients to crops sustainably, aiming to reduce the need for petrochemical fertilizers and improve crop yield.

Crop Enhancement

Series B in 2020
Crop Enhancement LLC is an early-stage specialty materials company based in San Jose, California, founded in 2011. The company focuses on developing innovative anchoring and controlled-release formulation technologies for agricultural chemicals. Its advanced agrochemical formulations utilize environmentally friendly chemistry to enhance crop yields and profitability while minimizing the reliance on synthetic pesticides. Crop Enhancement's products include proprietary films that modify plant surfaces, improving resistance to pests and diseases. This approach not only supports sustainable farming practices but also enables precise delivery of active ingredients and fertilizers, ultimately benefiting growers through increased efficiency and reduced chemical use.

Provivi

Series C in 2019
Provivi Inc. is a biotechnology company based in Santa Monica, California, focused on the development of biopesticides for agricultural, commercial, household, and public health pest management. Founded in 2013, the company leverages biocatalysis technology, originally developed at the California Institute of Technology, to create insect pheromones that protect food supplies without toxic residues. Provivi aims to provide effective and environmentally friendly crop protection solutions, fostering sustainable agricultural practices. Its innovative approach targets the synthesis of biopesticides through advanced processes, allowing for the efficient production of safe and affordable pest management products. The company distributes its offerings worldwide, seeking to transform pest control with its groundbreaking biological solutions.

Consumer Physics

Venture Round in 2018
Consumer Physics develops and markets SCiO, the smallest near-infrared spectrometer. It empowers consumers and businesses to analyze materials using a molecular sensor that connects to smartphone apps and a cloud-based database of material fingerprints.

Inscripta

Series C in 2018
Inscripta is a gene editing technology company developing scalable digital genome engineering based on CRISPR approaches. It offers MADzymes enzymes for precision editing and is building a benchtop platform comprising an instrument, consumables, software, and assays that enables automated, massively parallel, trackable editing of single cells. The platform aims to lower technical and licensing barriers, delivering push-button workflows and low-cost libraries of thousands of designer proteins, pathways, or genome variants, each with defined and trackable mutations. The company also pursues collaboration by making its MAD7 nuclease available free for research and development to broaden access and accelerate biological discovery.

Provivi

Series B in 2017
Provivi Inc. is a biotechnology company based in Santa Monica, California, focused on the development of biopesticides for agricultural, commercial, household, and public health pest management. Founded in 2013, the company leverages biocatalysis technology, originally developed at the California Institute of Technology, to create insect pheromones that protect food supplies without toxic residues. Provivi aims to provide effective and environmentally friendly crop protection solutions, fostering sustainable agricultural practices. Its innovative approach targets the synthesis of biopesticides through advanced processes, allowing for the efficient production of safe and affordable pest management products. The company distributes its offerings worldwide, seeking to transform pest control with its groundbreaking biological solutions.

Consumer Physics

Series C in 2017
Consumer Physics develops and markets SCiO, the smallest near-infrared spectrometer. It empowers consumers and businesses to analyze materials using a molecular sensor that connects to smartphone apps and a cloud-based database of material fingerprints.

Evolve Biosystems

Series B in 2017
Evolve Biosystems, Inc. is a life sciences company based in Davis, California, that focuses on developing probiotic-based biotherapeutics aimed at establishing, restoring, and maintaining a healthy human microbiome. Incorporated in 2011, the company utilizes a discovery platform that addresses dysbiosis issues throughout the human life cycle and in production animals. Evolve Biosystems specializes in probiotic bacteria activated with specific prebiotic oligosaccharides and employs various delivery systems to support gut health, particularly in infants during their first six months of life. Their product offerings include consumer-directed solutions for home use as well as specialized products for neonatal intensive care units, addressing unmet clinical needs in both human and animal health.

Amfora

Series A in 2017
Founded in 2016, Amfora is a biotechnology company based in San Francisco. It harnesses biology to sustainably enhance the nutritional density of food and feed crops, particularly focusing on increasing protein content through gene editing. The company aims to meet global demand for high-protein foods while reducing environmental impact.

Inscripta

Series B in 2017
Inscripta is a gene editing technology company developing scalable digital genome engineering based on CRISPR approaches. It offers MADzymes enzymes for precision editing and is building a benchtop platform comprising an instrument, consumables, software, and assays that enables automated, massively parallel, trackable editing of single cells. The platform aims to lower technical and licensing barriers, delivering push-button workflows and low-cost libraries of thousands of designer proteins, pathways, or genome variants, each with defined and trackable mutations. The company also pursues collaboration by making its MAD7 nuclease available free for research and development to broaden access and accelerate biological discovery.

Agerpoint

Series B in 2016
Agerpoint is a geospatial intelligence and data engineering company that builds a precision farming insights platform. It combines artificial intelligence, high‑performance computing, computer vision and advanced analytics to fuse data from mobile devices, ground vehicles, autonomous robots, drones, satellites, and human observations into a highly precise, quantifiable digital record of natural environments. The platform delivers actionable information on crop yields, disease detection, carbon sequestration, and biodiversity, and provides comprehensive GIS‑based asset inventories for growers, researchers, forestry managers, and government agencies. Founded in 2012 and headquartered in Research Triangle Park, North Carolina, Agerpoint’s mission is to improve quality of life and mitigate climate change by transforming how people understand and manage plants, crops, forests, and vegetation in built environments.

Gevo

Series D in 2010
Gevo specializes in producing renewable fuels and chemicals using sustainable resources. Its primary products include gasoline, jet fuel, diesel fuel, isobutanol, and renewable natural gas. The company aims to reduce greenhouse gas emissions by providing low-carbon alternatives to fossil fuels.
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