SV Health Investors

Perfuze is a neurovascular medical device company based in Galway, Ireland, established in 2018. The company specializes in developing innovative catheter technology aimed at treating acute ischemic stroke. By utilizing its proprietary catheter-based aspiration platform, Perfuze focuses on optimizing the efficiency of clot removal, which in turn seeks to enhance clinical outcomes and reduce procedural times. This technology aims to simplify the treatment process while minimizing the need for alternative interventions, providing patients with a cost-effective solution for ischemic stroke therapy.

Spectrawave, Inc. is a medical device company based in Waltham, Massachusetts, founded in 2017. The company specializes in developing and manufacturing optical diagnostic and therapeutic devices aimed at enhancing the diagnosis and treatment of cardiovascular diseases. One of its key innovations is a spectroscopy catheter that integrates advanced imaging technologies to improve outcomes for patients with coronary artery disease (CAD). This cutting-edge imaging system provides interventional cardiologists with crucial optical and computational insights, enabling them to identify patients and plaque formations that may pose risks for future coronary complications. Through its focus on photonics, Spectrawave aims to optimize stent interventions and improve overall patient care in the field of cardiovascular medicine.

CSA Medical, Inc. specializes in the development and manufacturing of spray cryotherapy medical devices. The company's flagship product, the truFreeze device, utilizes cold liquid nitrogen as a cryosurgical tool for the destruction of unwanted tissue in dermatology, gynecology, and general surgery, while facilitating the regrowth of healthy tissue. Additionally, CSA Medical offers the Rapid AV Spray Kit, which enhances the truFreeze system by reducing the time required for liquid nitrogen application. Originally founded as Crymed Technologies in 1993, the company rebranded to CSA Medical in April 2006. Headquartered in Lutherville Timonium, Maryland, CSA Medical also operates a research and development facility in Lexington, Massachusetts.

Spineology Inc. is a medical technology company that specializes in anatomy-conserving solutions for spine surgery. Founded in 1996 and based in Saint Paul, Minnesota, the company offers a range of products including pedicular fixation systems such as Threshold and Fortress, spinal fixation systems like CapLOX II, and biological products including Prime, a liquid tissue matrix, and Armor, an allograft for wound covering. Their portfolio also features interbody fusion systems like Rampart O and Rampart T, as well as instruments for facet fixation, spinous process fixation, and retraction systems such as Medius and SOAR. Additionally, Spineology provides ProMap, an EMG navigation system, and OptiMesh, a graft containment solution. The company’s innovations enable healthcare professionals to perform minimally invasive surgeries, enhancing procedural efficiency and improving patient recovery outcomes.

Miach Orthopaedics is a medical device company based in Westborough, Massachusetts, founded in 2016. The company specializes in developing bio-engineered surgical implants aimed at facilitating new tissue growth and aiding in connective tissue repair. Its primary product, the Bridge-Enhanced ACL Repair technology, offers a viable alternative to traditional anterior cruciate ligament (ACL) reconstruction for patients who have suffered ACL injuries. This innovative approach enables surgeons to restore the normal anatomy and function of the knee, enhancing recovery outcomes for patients.

Robling Medical is a designer and manufacturer of medical products, focusing on providing contract manufacturing services for medical organizations. The company specializes in various aspects of product development, including design, assembly process design, manufacturing, packaging, sterilization, and distribution of medical devices. By offering comprehensive engineering support and ensuring regulatory compliance, Robling Medical assists its clients in bringing their medical devices to market effectively.

PayMedix began as the healthcare payment platform for Health Payment Systems (HPS) in 2008. HPS, headquartered in Milwaukee, Wisconsin, is a privately held healthcare technology and services organization with an independent network of 96 hospital facilities and 22,600 individual providers. PayMedix has processed more than $5 billion in medical payments for hospital systems and physician practices and can be implemented with any PPO or HMO network.

Perfuze is a neurovascular medical device company based in Galway, Ireland, established in 2018. The company specializes in developing innovative catheter technology aimed at treating acute ischemic stroke. By utilizing its proprietary catheter-based aspiration platform, Perfuze focuses on optimizing the efficiency of clot removal, which in turn seeks to enhance clinical outcomes and reduce procedural times. This technology aims to simplify the treatment process while minimizing the need for alternative interventions, providing patients with a cost-effective solution for ischemic stroke therapy.

PayMedix began as the healthcare payment platform for Health Payment Systems (HPS) in 2008. HPS, headquartered in Milwaukee, Wisconsin, is a privately held healthcare technology and services organization with an independent network of 96 hospital facilities and 22,600 individual providers. PayMedix has processed more than $5 billion in medical payments for hospital systems and physician practices and can be implemented with any PPO or HMO network.

Leiters is an FDA-registered 503B outsourcing provider specializing in high-quality ophthalmology and hospital-based services. The company focuses on delivering compounded sterile preparations to hospitals, surgery centers, and physician offices. Its extensive portfolio includes ready-to-administer products such as pre-filled syringes, vials, bags, and injectable compounds, along with opioid-free surgical pain services and various ophthalmic solutions. With a team of experts in sterile pharmaceutical manufacturing, repackaging, and compounding, Leiters is dedicated to ensuring quality and consistency in its offerings. The company has a long-standing commitment to patient health and has served healthcare professionals for nearly a century, reinforcing its reputation for reliability in providing critically needed outsourced medications.

Evidation Health, Inc. specializes in developing digital tools and technologies for healthcare data analytics. The company connects digital health firms with healthcare providers and payers through its advanced platform, which transforms everyday behavior data from various sources, including sensors and devices, into actionable insights regarding health and disease. Its products include a Data Platform that analyzes this high-frequency behavior data and a technology-enabled service called Studies, which facilitates real-world research to support clinical and commercial efforts. By focusing on the interplay between everyday behaviors and health outcomes, Evidation aims to empower individuals and healthcare companies to improve health management outside traditional clinical settings. Founded in 2012 and headquartered in San Mateo, California, the company also operates additional offices in San Francisco and Santa Barbara.

AeroCare Holdings, Inc., established in 2002 and headquartered in Orlando, Florida, specializes in distributing home medical equipment in the United States. The company offers a range of respiratory products, including oxygen, CPAP/BiPAP machines and supplies, nebulizers, and oxygen concentrator instructions, catering to patients with breathing difficulties such as COPD, CHF, and OSA. Additionally, AeroCare provides mobility aids like wheelchairs, walkers, and canes, along with other daily living and medical supplies. The company sells its products through customer service representatives and offers direct purchasing options for CPAP and respiratory equipment, recognizing insurance limitations.

Bardy Diagnostics, Inc. is a medical device company that specializes in the development and manufacturing of cardiac monitoring solutions, primarily focused on arrhythmia detection. Its flagship product, the Carnation Ambulatory Monitor (CAM), is a lightweight, discreet cardiac patch that can be worn comfortably for up to seven days, even during physical activities like exercise or showering. The CAM is designed with a unique hourglass shape to enhance comfort, particularly for female patients. Complementing the monitor is the BDxCONNECT patient management system, which allows healthcare providers to create and manage patient reports efficiently. By utilizing innovative P-wave centric ECG detection technology, Bardy Diagnostics aims to improve clinical management and outcomes for patients and their physicians. Founded in 2013, the company is headquartered in Seattle, Washington, with additional offices in Houston, Texas, and New Providence, New Jersey.

CSA Medical, Inc. specializes in the development and manufacturing of spray cryotherapy medical devices. The company's flagship product, the truFreeze device, utilizes cold liquid nitrogen as a cryosurgical tool for the destruction of unwanted tissue in dermatology, gynecology, and general surgery, while facilitating the regrowth of healthy tissue. Additionally, CSA Medical offers the Rapid AV Spray Kit, which enhances the truFreeze system by reducing the time required for liquid nitrogen application. Originally founded as Crymed Technologies in 1993, the company rebranded to CSA Medical in April 2006. Headquartered in Lutherville Timonium, Maryland, CSA Medical also operates a research and development facility in Lexington, Massachusetts.

Endotronix Inc. is a developer of advanced hemodynamic monitoring technologies focused on early detection of worsening heart failure. Founded in 2007 and based in Lisle, Illinois, the company specializes in miniaturized, wireless, and implantable pressure sensors that are utilized in interventional cardiovascular procedures. These sensors connect to an external measurement device and are part of a comprehensive platform that includes cloud-based disease management and outpatient hemodynamic management. Endotronix's innovative tools facilitate patient management by linking patients, clinicians, and reimbursement teams, ultimately enhancing clinical and economic outcomes. The company's technology aims to improve proactive heart management and empower health professionals to monitor patients' conditions effectively from home.

Evidation Health, Inc. specializes in developing digital tools and technologies for healthcare data analytics. The company connects digital health firms with healthcare providers and payers through its advanced platform, which transforms everyday behavior data from various sources, including sensors and devices, into actionable insights regarding health and disease. Its products include a Data Platform that analyzes this high-frequency behavior data and a technology-enabled service called Studies, which facilitates real-world research to support clinical and commercial efforts. By focusing on the interplay between everyday behaviors and health outcomes, Evidation aims to empower individuals and healthcare companies to improve health management outside traditional clinical settings. Founded in 2012 and headquartered in San Mateo, California, the company also operates additional offices in San Francisco and Santa Barbara.

Stimwave LLC is a medical device company focused on developing, manufacturing, and marketing wireless microsize injectable devices for neurology applications. The company's product offerings include the Freedom SCS System, a spinal cord stimulator designed to alleviate chronic low back and leg pain, and the StimQ PNS System, a peripheral nerve stimulator that addresses chronic pain by targeting specific peripheral nerves. Originally incorporated as Neural Micro Incorporated in 2010, Stimwave LLC is headquartered in Pompano Beach, Florida.

Bardy Diagnostics, Inc. is a medical device company that specializes in the development and manufacturing of cardiac monitoring solutions, primarily focused on arrhythmia detection. Its flagship product, the Carnation Ambulatory Monitor (CAM), is a lightweight, discreet cardiac patch that can be worn comfortably for up to seven days, even during physical activities like exercise or showering. The CAM is designed with a unique hourglass shape to enhance comfort, particularly for female patients. Complementing the monitor is the BDxCONNECT patient management system, which allows healthcare providers to create and manage patient reports efficiently. By utilizing innovative P-wave centric ECG detection technology, Bardy Diagnostics aims to improve clinical management and outcomes for patients and their physicians. Founded in 2013, the company is headquartered in Seattle, Washington, with additional offices in Houston, Texas, and New Providence, New Jersey.

Good Start Genetics, Inc. is a molecular diagnostics company based in Cambridge, Massachusetts, focused on genetic screening for inherited diseases. Founded in 2007, the company aims to transform reproductive medicine by providing physicians and patients with actionable insights into inherited genetic disorders. Good Start Genetics offers a range of services, including EmbryVu, a preimplantation genetic screening test designed to enhance in vitro fertilization outcomes by identifying suitable embryos for implantation. The company employs advanced next-generation DNA sequencing technology, along with other established genetic screening methods, to deliver high carrier detection rates. Additionally, through its GoodStart Select program, it provides a comprehensive menu of genetic carrier screening tests for both known and novel mutations, all supported by a commitment to customer care and genetic counseling. As of August 2017, Good Start Genetics operates as a subsidiary of Invitae Corporation.

CardioKinetix, Inc., based in Menlo Park, California, specializes in developing transcatheter implants aimed at treating heart failure. The company's primary product, the Parachute Ventricular Partitioning Device, is designed to improve cardiac function in patients who have developed ischemic left-sided heart failure following a heart attack. By isolating the dysfunctional region of the heart ventricle and reducing chamber volume, the device enhances cardiac output, addressing a critical need in heart failure management. CardioKinetix serves a diverse customer base across several countries, including the United States and various European nations, and aims to provide effective treatment options for millions affected by heart failure globally. The company was incorporated in 2002.

CSA Medical, Inc. specializes in the development and manufacturing of spray cryotherapy medical devices. The company's flagship product, the truFreeze device, utilizes cold liquid nitrogen as a cryosurgical tool for the destruction of unwanted tissue in dermatology, gynecology, and general surgery, while facilitating the regrowth of healthy tissue. Additionally, CSA Medical offers the Rapid AV Spray Kit, which enhances the truFreeze system by reducing the time required for liquid nitrogen application. Originally founded as Crymed Technologies in 1993, the company rebranded to CSA Medical in April 2006. Headquartered in Lutherville Timonium, Maryland, CSA Medical also operates a research and development facility in Lexington, Massachusetts.

Cibiem Inc. is a medical device company that specializes in the development of minimally invasive, catheter-based technologies for treating diseases mediated by the sympathetic nervous system, including hypertension, heart failure, diabetes, and renal failure. The company focuses on Carotid Body Modulation (CBM), which offers a novel approach to managing these serious health conditions. Founded in 2010 and based in Los Altos, California, with an additional office in Teaneck, New Jersey, Cibiem was co-founded by Mark Gelfand and Howard R. Levin, M.D. The company is supported by prominent venture investors, including Third Rock Ventures and SV Life Sciences, reflecting its innovative potential in the medical device sector.

ValenTx, Inc. is a medical device company based in Maple Grove, Minnesota, established in 2002. It specializes in developing minimally invasive therapy solutions aimed at treating obesity and its related metabolic disorders, including type-2 diabetes and hypertension. One of its key innovations is an endoluminal bypass therapy that replicates the anatomical changes associated with the Roux-en-Y gastric bypass procedure using an adjustable, removable, and replaceable device. ValenTx's focus is on providing effective treatment options for individuals struggling with morbid obesity and related health issues.

CardioFocus, Inc. is a biotechnology company based in Marlborough, Massachusetts, that specializes in the development of innovative medical devices for the treatment of cardiac disorders, particularly atrial fibrillation. The company offers a range of products, including the HeartLight Endoscopic Ablation System, which utilizes visually guided laser balloon technology to achieve precise pulmonary vein isolation. This system is complemented by the HeartLight Excalibur Balloon, designed for stable contact and effective lesion creation through direct tissue visualization, and the HeartLight X3 System, which allows for controlled lesion formation. CardioFocus focuses on providing electrophysiologists with advanced tools that enhance the precision and control of ablation treatments, utilizing disposable fiber optic catheters for improved visualization of cardiac anatomy and the treatment of arrhythmias. Founded in 1990, CardioFocus continues to pursue advancements in ablation technologies to better meet the needs of patients and healthcare providers.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to restore near vision for presbyopic patients while preserving distance vision. Additionally, AcuFocus develops the IC-8 IOL, a small aperture lens that facilitates a range of vision for patients with cataracts. The AcuTarget HD is another key product, serving as a diagnostic and surgical planning instrument for various vision correction procedures, including LASIK and cataract surgeries. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, addressing the needs of both physicians and patients in the vision care sector. Founded in 2001, AcuFocus continues to focus on innovative solutions for vision-related challenges.

Good Start Genetics, Inc. is a molecular diagnostics company based in Cambridge, Massachusetts, focused on genetic screening for inherited diseases. Founded in 2007, the company aims to transform reproductive medicine by providing physicians and patients with actionable insights into inherited genetic disorders. Good Start Genetics offers a range of services, including EmbryVu, a preimplantation genetic screening test designed to enhance in vitro fertilization outcomes by identifying suitable embryos for implantation. The company employs advanced next-generation DNA sequencing technology, along with other established genetic screening methods, to deliver high carrier detection rates. Additionally, through its GoodStart Select program, it provides a comprehensive menu of genetic carrier screening tests for both known and novel mutations, all supported by a commitment to customer care and genetic counseling. As of August 2017, Good Start Genetics operates as a subsidiary of Invitae Corporation.

Direct Flow Medical is a medical device company focused on developing innovative transcatheter aortic valve replacement systems aimed at treating cardiac valve insufficiency. The company’s flagship product is a percutaneous aortic tissue valve prosthesis designed to offer a safe and effective alternative for patients, particularly those over the age of 65 who suffer from calcified aortic valves. Despite the prevalence of this condition, with approximately 1.2 million affected individuals, only around 150,000 receive surgical treatment annually. Direct Flow Medical's technology enhances patient outcomes and minimizes complications by allowing heart surgeons to perform valve replacements without invasive surgery, using repeated assessments of hemodynamic performance prior to final implantation.

Endotronix Inc. is a developer of advanced hemodynamic monitoring technologies focused on early detection of worsening heart failure. Founded in 2007 and based in Lisle, Illinois, the company specializes in miniaturized, wireless, and implantable pressure sensors that are utilized in interventional cardiovascular procedures. These sensors connect to an external measurement device and are part of a comprehensive platform that includes cloud-based disease management and outpatient hemodynamic management. Endotronix's innovative tools facilitate patient management by linking patients, clinicians, and reimbursement teams, ultimately enhancing clinical and economic outcomes. The company's technology aims to improve proactive heart management and empower health professionals to monitor patients' conditions effectively from home.

CardioFocus, Inc. is a biotechnology company based in Marlborough, Massachusetts, that specializes in the development of innovative medical devices for the treatment of cardiac disorders, particularly atrial fibrillation. The company offers a range of products, including the HeartLight Endoscopic Ablation System, which utilizes visually guided laser balloon technology to achieve precise pulmonary vein isolation. This system is complemented by the HeartLight Excalibur Balloon, designed for stable contact and effective lesion creation through direct tissue visualization, and the HeartLight X3 System, which allows for controlled lesion formation. CardioFocus focuses on providing electrophysiologists with advanced tools that enhance the precision and control of ablation treatments, utilizing disposable fiber optic catheters for improved visualization of cardiac anatomy and the treatment of arrhythmias. Founded in 1990, CardioFocus continues to pursue advancements in ablation technologies to better meet the needs of patients and healthcare providers.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to restore near vision for presbyopic patients while preserving distance vision. Additionally, AcuFocus develops the IC-8 IOL, a small aperture lens that facilitates a range of vision for patients with cataracts. The AcuTarget HD is another key product, serving as a diagnostic and surgical planning instrument for various vision correction procedures, including LASIK and cataract surgeries. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, addressing the needs of both physicians and patients in the vision care sector. Founded in 2001, AcuFocus continues to focus on innovative solutions for vision-related challenges.

AeroCare Holdings, Inc., established in 2002 and headquartered in Orlando, Florida, specializes in distributing home medical equipment in the United States. The company offers a range of respiratory products, including oxygen, CPAP/BiPAP machines and supplies, nebulizers, and oxygen concentrator instructions, catering to patients with breathing difficulties such as COPD, CHF, and OSA. Additionally, AeroCare provides mobility aids like wheelchairs, walkers, and canes, along with other daily living and medical supplies. The company sells its products through customer service representatives and offers direct purchasing options for CPAP and respiratory equipment, recognizing insurance limitations.

Good Start Genetics, Inc. is a molecular diagnostics company based in Cambridge, Massachusetts, focused on genetic screening for inherited diseases. Founded in 2007, the company aims to transform reproductive medicine by providing physicians and patients with actionable insights into inherited genetic disorders. Good Start Genetics offers a range of services, including EmbryVu, a preimplantation genetic screening test designed to enhance in vitro fertilization outcomes by identifying suitable embryos for implantation. The company employs advanced next-generation DNA sequencing technology, along with other established genetic screening methods, to deliver high carrier detection rates. Additionally, through its GoodStart Select program, it provides a comprehensive menu of genetic carrier screening tests for both known and novel mutations, all supported by a commitment to customer care and genetic counseling. As of August 2017, Good Start Genetics operates as a subsidiary of Invitae Corporation.

Soffio Medical is a Boston-based company that develops medical devices aimed at treating respiratory diseases. The company's innovative approach focuses on implantable devices designed to implement an airway bypass concept. This technology allows for the venting of trapped air from areas distal to high-resistance airways, which helps to reduce residual lung volume. By alleviating symptoms associated with chronic obstructive pulmonary disease, Soffio Medical's solutions aim to enhance the quality of life for patients suffering from these conditions.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to restore near vision for presbyopic patients while preserving distance vision. Additionally, AcuFocus develops the IC-8 IOL, a small aperture lens that facilitates a range of vision for patients with cataracts. The AcuTarget HD is another key product, serving as a diagnostic and surgical planning instrument for various vision correction procedures, including LASIK and cataract surgeries. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, addressing the needs of both physicians and patients in the vision care sector. Founded in 2001, AcuFocus continues to focus on innovative solutions for vision-related challenges.

Cibiem Inc. is a medical device company that specializes in the development of minimally invasive, catheter-based technologies for treating diseases mediated by the sympathetic nervous system, including hypertension, heart failure, diabetes, and renal failure. The company focuses on Carotid Body Modulation (CBM), which offers a novel approach to managing these serious health conditions. Founded in 2010 and based in Los Altos, California, with an additional office in Teaneck, New Jersey, Cibiem was co-founded by Mark Gelfand and Howard R. Levin, M.D. The company is supported by prominent venture investors, including Third Rock Ventures and SV Life Sciences, reflecting its innovative potential in the medical device sector.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to restore near vision for presbyopic patients while preserving distance vision. Additionally, AcuFocus develops the IC-8 IOL, a small aperture lens that facilitates a range of vision for patients with cataracts. The AcuTarget HD is another key product, serving as a diagnostic and surgical planning instrument for various vision correction procedures, including LASIK and cataract surgeries. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, addressing the needs of both physicians and patients in the vision care sector. Founded in 2001, AcuFocus continues to focus on innovative solutions for vision-related challenges.

Deciphera Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company based in Waltham, Massachusetts, focused on developing innovative treatments for cancer. The company aims to improve the lives of cancer patients by addressing mechanisms of drug resistance that hinder effective therapy responses. Its lead candidate, ripretinib, is specifically designed for gastrointestinal stromal tumors and is undergoing trials for various other cancers, including gliomas and melanoma. Additionally, Deciphera is advancing other clinical-stage candidates, such as DCC-3014, targeting tenosynovial giant cell tumors, and Rebastinib, which is being explored in combination with chemotherapy for solid tumors. The company also has a preclinical candidate, DCC-3116, aimed at treating RAS mutant cancers. Deciphera leverages its proprietary switch-control kinase inhibitor platform and has received regulatory approvals for its lead product in several countries, enhancing its commitment to developing vital cancer therapies.

EBR Systems, Inc. is focused on developing innovative implantable devices for cardiac rhythm management, specifically aimed at treating patients with heart failure and cardiac arrhythmias. The company's flagship product, the Wireless Cardiac Stimulation of the Left Ventricle System, utilizes proprietary wireless technology to provide endocardial pacing for cardiac resynchronization therapy. This approach enhances the heart's pumping efficiency by synchronizing the contractions of the left and right ventricles. Founded in 2003 and headquartered in Sunnyvale, California, EBR Systems is committed to advancing therapeutic options for patients suffering from cardiac rhythm diseases through its novel technologies.

CardioKinetix, Inc., based in Menlo Park, California, specializes in developing transcatheter implants aimed at treating heart failure. The company's primary product, the Parachute Ventricular Partitioning Device, is designed to improve cardiac function in patients who have developed ischemic left-sided heart failure following a heart attack. By isolating the dysfunctional region of the heart ventricle and reducing chamber volume, the device enhances cardiac output, addressing a critical need in heart failure management. CardioKinetix serves a diverse customer base across several countries, including the United States and various European nations, and aims to provide effective treatment options for millions affected by heart failure globally. The company was incorporated in 2002.

Direct Flow Medical is a medical device company focused on developing innovative transcatheter aortic valve replacement systems aimed at treating cardiac valve insufficiency. The company’s flagship product is a percutaneous aortic tissue valve prosthesis designed to offer a safe and effective alternative for patients, particularly those over the age of 65 who suffer from calcified aortic valves. Despite the prevalence of this condition, with approximately 1.2 million affected individuals, only around 150,000 receive surgical treatment annually. Direct Flow Medical's technology enhances patient outcomes and minimizes complications by allowing heart surgeons to perform valve replacements without invasive surgery, using repeated assessments of hemodynamic performance prior to final implantation.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to restore near vision for presbyopic patients while preserving distance vision. Additionally, AcuFocus develops the IC-8 IOL, a small aperture lens that facilitates a range of vision for patients with cataracts. The AcuTarget HD is another key product, serving as a diagnostic and surgical planning instrument for various vision correction procedures, including LASIK and cataract surgeries. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, addressing the needs of both physicians and patients in the vision care sector. Founded in 2001, AcuFocus continues to focus on innovative solutions for vision-related challenges.

Spinal Kinetics LLC is a medical device company based in Sunnyvale, California, dedicated to developing non-fusion motion preservation systems for treating degenerative diseases of the spine. Founded in 2003, the company offers two primary products: the M6-C artificial cervical disc and the M6-L artificial lumbar disc, both designed to replicate the anatomical and biomechanical characteristics of natural intervertebral discs. These innovations provide options for artificial disc replacement in the cervical and lumbar regions. Spinal Kinetics collaborates with spine surgeons to ensure that its products meet clinical needs and are sold through a network of distributors across various countries, including Australia, Germany, the United Kingdom, and the United Arab Emirates. The company operates as a subsidiary of Orthofix Medical Inc.

CardioFocus, Inc. is a biotechnology company based in Marlborough, Massachusetts, that specializes in the development of innovative medical devices for the treatment of cardiac disorders, particularly atrial fibrillation. The company offers a range of products, including the HeartLight Endoscopic Ablation System, which utilizes visually guided laser balloon technology to achieve precise pulmonary vein isolation. This system is complemented by the HeartLight Excalibur Balloon, designed for stable contact and effective lesion creation through direct tissue visualization, and the HeartLight X3 System, which allows for controlled lesion formation. CardioFocus focuses on providing electrophysiologists with advanced tools that enhance the precision and control of ablation treatments, utilizing disposable fiber optic catheters for improved visualization of cardiac anatomy and the treatment of arrhythmias. Founded in 1990, CardioFocus continues to pursue advancements in ablation technologies to better meet the needs of patients and healthcare providers.

AqueSys, Inc. is an ophthalmic company based in Aliso Viejo, California, specializing in the development and commercialization of innovative implantable devices for glaucoma treatment. Founded in 2005, the company is known for its XEN gel stent, which facilitates the outflow of aqueous fluid from the anterior chamber to the subconjunctival space, effectively lowering intraocular pressure. This device creates a new drainage pathway, enhancing patient outcomes in glaucoma management. AqueSys operates as a subsidiary of Allergan plc, focusing on advancing surgical solutions to improve eye health.

CSA Medical, Inc. specializes in the development and manufacturing of spray cryotherapy medical devices. The company's flagship product, the truFreeze device, utilizes cold liquid nitrogen as a cryosurgical tool for the destruction of unwanted tissue in dermatology, gynecology, and general surgery, while facilitating the regrowth of healthy tissue. Additionally, CSA Medical offers the Rapid AV Spray Kit, which enhances the truFreeze system by reducing the time required for liquid nitrogen application. Originally founded as Crymed Technologies in 1993, the company rebranded to CSA Medical in April 2006. Headquartered in Lutherville Timonium, Maryland, CSA Medical also operates a research and development facility in Lexington, Massachusetts.

Soffio Medical is a Boston-based company that develops medical devices aimed at treating respiratory diseases. The company's innovative approach focuses on implantable devices designed to implement an airway bypass concept. This technology allows for the venting of trapped air from areas distal to high-resistance airways, which helps to reduce residual lung volume. By alleviating symptoms associated with chronic obstructive pulmonary disease, Soffio Medical's solutions aim to enhance the quality of life for patients suffering from these conditions.

Oncoethix SA is a private Swiss company that was founded in 2007 by Esteban Cvitkovic, MD, Kay Noel, PhD, Yves Paternot, and Patrice Herait, MD (all former associates at Cvitkovic & Associes Consultants SA) to develop a portfolio of 3 to 5 promising new drugs for cancer treatment. The company intends to develop its compounds through clinical proof of concept and the identification of an expedited registration strategy, after which pharmaceutical partners will be sought to fund pivotal trials and handle commercialization. Oncoethix founders have an unsurpassed track record in identifying and bringing oncology leads to global markets. Dr. Cvitkovic, Chief Scientific Officer for Oncoethix, led the clinical development of single agent and combination regimens for cisplatin, vindesine, bleomycin, navelbine, and, more recently, irinotecan, oxaliplatin, docetaxel, and trabectedin, first as an academic investigator and then through a specialized oncology clinical research organization. Prior to founding Oncoethix and assuming responsibilities as Chief Operating Officer, Dr. Noel had co-founded another oncology drug development company which in-licensed oxaliplatin as its first portfolio product and subsequently identified, evaluated, and in-licensed novel agents for several clients. Additionally, Dr. Noel has developed expedited registration strategies for many cancer drugs and registration files for a few of these. Dr. Herait managed clinical development of irinotecan, from Phase 1 through Phase 3, while at Rhone Poulenc Rorer and subsequently, as a consultant, managed clinical studies for several novel cancer drugs. Since its founding, Oncoethix has in-licensed three promising cancer drug candidates, each a first-in-class agent to a novel target or with a novel mode of action. Currently, two portfolio compounds are in clinical development. Oncoethix was launched with an initial financing of 1.30 million Swiss francs from the founders to finance portfolio development. In December 2009, the company closed a Series A financing of 3.7 million Swiss francs with leading venture capital firms Index Ventures and Endeavour Vision.

CardioKinetix, Inc., based in Menlo Park, California, specializes in developing transcatheter implants aimed at treating heart failure. The company's primary product, the Parachute Ventricular Partitioning Device, is designed to improve cardiac function in patients who have developed ischemic left-sided heart failure following a heart attack. By isolating the dysfunctional region of the heart ventricle and reducing chamber volume, the device enhances cardiac output, addressing a critical need in heart failure management. CardioKinetix serves a diverse customer base across several countries, including the United States and various European nations, and aims to provide effective treatment options for millions affected by heart failure globally. The company was incorporated in 2002.

Cibiem Inc. is a medical device company that specializes in the development of minimally invasive, catheter-based technologies for treating diseases mediated by the sympathetic nervous system, including hypertension, heart failure, diabetes, and renal failure. The company focuses on Carotid Body Modulation (CBM), which offers a novel approach to managing these serious health conditions. Founded in 2010 and based in Los Altos, California, with an additional office in Teaneck, New Jersey, Cibiem was co-founded by Mark Gelfand and Howard R. Levin, M.D. The company is supported by prominent venture investors, including Third Rock Ventures and SV Life Sciences, reflecting its innovative potential in the medical device sector.

MindFrame, Inc. specializes in developing medical devices for the treatment of ischemic stroke. Founded in 2007 and based in Irvine, California, the company focuses on solutions that enhance patient outcomes through innovative technology. Its flagship device, MindFrame Capture, facilitates rapid flow restoration and clot extraction, enabling clinicians to improve treatment efficiency. Additionally, MindFrame offers specialized products for various arterial territories, including the internal carotid arteries and basilar arteries. The company's MindFrame Flow device further enhances treatment by creating a bypass for faster restoration of blood flow, which aids in delivering critical therapies to dissolve clots. As of 2012, MindFrame operates as a subsidiary of Covidien plc.

Good Start Genetics, Inc. is a molecular diagnostics company based in Cambridge, Massachusetts, focused on genetic screening for inherited diseases. Founded in 2007, the company aims to transform reproductive medicine by providing physicians and patients with actionable insights into inherited genetic disorders. Good Start Genetics offers a range of services, including EmbryVu, a preimplantation genetic screening test designed to enhance in vitro fertilization outcomes by identifying suitable embryos for implantation. The company employs advanced next-generation DNA sequencing technology, along with other established genetic screening methods, to deliver high carrier detection rates. Additionally, through its GoodStart Select program, it provides a comprehensive menu of genetic carrier screening tests for both known and novel mutations, all supported by a commitment to customer care and genetic counseling. As of August 2017, Good Start Genetics operates as a subsidiary of Invitae Corporation.

AlloCure, Inc. is a biotechnology company focused on developing cell therapies for kidney diseases and related conditions. Founded in 2006 and based in Burlington, Massachusetts, with additional operations in Salt Lake City, Utah, and Hamburg, Germany, the company specializes in biologic therapies for acute kidney injuries and other serious illnesses. Central to AlloCure's approach is its unique technology that utilizes processed cells derived from human bone marrow, aiming to create off-the-shelf biological treatments for a range of debilitating diseases. The company was established based on the proprietary research of renowned scientists Dr. Christof Westenfelder and Dr. Axel Zander, who have dedicated their careers to advancing effective therapies for kidney-related ailments.

CSA Medical, Inc. specializes in the development and manufacturing of spray cryotherapy medical devices. The company's flagship product, the truFreeze device, utilizes cold liquid nitrogen as a cryosurgical tool for the destruction of unwanted tissue in dermatology, gynecology, and general surgery, while facilitating the regrowth of healthy tissue. Additionally, CSA Medical offers the Rapid AV Spray Kit, which enhances the truFreeze system by reducing the time required for liquid nitrogen application. Originally founded as Crymed Technologies in 1993, the company rebranded to CSA Medical in April 2006. Headquartered in Lutherville Timonium, Maryland, CSA Medical also operates a research and development facility in Lexington, Massachusetts.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to restore near vision for presbyopic patients while preserving distance vision. Additionally, AcuFocus develops the IC-8 IOL, a small aperture lens that facilitates a range of vision for patients with cataracts. The AcuTarget HD is another key product, serving as a diagnostic and surgical planning instrument for various vision correction procedures, including LASIK and cataract surgeries. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, addressing the needs of both physicians and patients in the vision care sector. Founded in 2001, AcuFocus continues to focus on innovative solutions for vision-related challenges.

CardioKinetix, Inc., based in Menlo Park, California, specializes in developing transcatheter implants aimed at treating heart failure. The company's primary product, the Parachute Ventricular Partitioning Device, is designed to improve cardiac function in patients who have developed ischemic left-sided heart failure following a heart attack. By isolating the dysfunctional region of the heart ventricle and reducing chamber volume, the device enhances cardiac output, addressing a critical need in heart failure management. CardioKinetix serves a diverse customer base across several countries, including the United States and various European nations, and aims to provide effective treatment options for millions affected by heart failure globally. The company was incorporated in 2002.

Entellus Medical, doing business as Stryker ENT, is a medical device company based in Plymouth, Minnesota, specializing in innovative solutions for ear, nose, and throat (ENT) treatments. Founded in 2006, Entellus develops and commercializes minimally invasive products aimed at addressing chronic sinusitis, eustachian tube dysfunction, and nasal airway obstruction. Its product lineup includes the XprESS ENT dilation system, which offers versatility for sinus and eustachian tube procedures, and the FinESS Sinus Treatment, a direct and effective method for treating chronic rhinosinusitis that minimizes invasiveness and recovery time. The company also provides a range of surgical instruments, imaging solutions, and other tools that enhance patient care while reducing discomfort and the need for general anesthesia. By collaborating with researchers and clinicians, Entellus Medical works to meet the unmet needs of physicians and patients alike, thereby improving treatment outcomes in the ENT field.

CardioFocus, Inc. is a biotechnology company based in Marlborough, Massachusetts, that specializes in the development of innovative medical devices for the treatment of cardiac disorders, particularly atrial fibrillation. The company offers a range of products, including the HeartLight Endoscopic Ablation System, which utilizes visually guided laser balloon technology to achieve precise pulmonary vein isolation. This system is complemented by the HeartLight Excalibur Balloon, designed for stable contact and effective lesion creation through direct tissue visualization, and the HeartLight X3 System, which allows for controlled lesion formation. CardioFocus focuses on providing electrophysiologists with advanced tools that enhance the precision and control of ablation treatments, utilizing disposable fiber optic catheters for improved visualization of cardiac anatomy and the treatment of arrhythmias. Founded in 1990, CardioFocus continues to pursue advancements in ablation technologies to better meet the needs of patients and healthcare providers.

EBR Systems, Inc. is focused on developing innovative implantable devices for cardiac rhythm management, specifically aimed at treating patients with heart failure and cardiac arrhythmias. The company's flagship product, the Wireless Cardiac Stimulation of the Left Ventricle System, utilizes proprietary wireless technology to provide endocardial pacing for cardiac resynchronization therapy. This approach enhances the heart's pumping efficiency by synchronizing the contractions of the left and right ventricles. Founded in 2003 and headquartered in Sunnyvale, California, EBR Systems is committed to advancing therapeutic options for patients suffering from cardiac rhythm diseases through its novel technologies.

Cibiem Inc. is a medical device company that specializes in the development of minimally invasive, catheter-based technologies for treating diseases mediated by the sympathetic nervous system, including hypertension, heart failure, diabetes, and renal failure. The company focuses on Carotid Body Modulation (CBM), which offers a novel approach to managing these serious health conditions. Founded in 2010 and based in Los Altos, California, with an additional office in Teaneck, New Jersey, Cibiem was co-founded by Mark Gelfand and Howard R. Levin, M.D. The company is supported by prominent venture investors, including Third Rock Ventures and SV Life Sciences, reflecting its innovative potential in the medical device sector.

Good Start Genetics, Inc. is a molecular diagnostics company based in Cambridge, Massachusetts, focused on genetic screening for inherited diseases. Founded in 2007, the company aims to transform reproductive medicine by providing physicians and patients with actionable insights into inherited genetic disorders. Good Start Genetics offers a range of services, including EmbryVu, a preimplantation genetic screening test designed to enhance in vitro fertilization outcomes by identifying suitable embryos for implantation. The company employs advanced next-generation DNA sequencing technology, along with other established genetic screening methods, to deliver high carrier detection rates. Additionally, through its GoodStart Select program, it provides a comprehensive menu of genetic carrier screening tests for both known and novel mutations, all supported by a commitment to customer care and genetic counseling. As of August 2017, Good Start Genetics operates as a subsidiary of Invitae Corporation.

MindFrame, Inc. specializes in developing medical devices for the treatment of ischemic stroke. Founded in 2007 and based in Irvine, California, the company focuses on solutions that enhance patient outcomes through innovative technology. Its flagship device, MindFrame Capture, facilitates rapid flow restoration and clot extraction, enabling clinicians to improve treatment efficiency. Additionally, MindFrame offers specialized products for various arterial territories, including the internal carotid arteries and basilar arteries. The company's MindFrame Flow device further enhances treatment by creating a bypass for faster restoration of blood flow, which aids in delivering critical therapies to dissolve clots. As of 2012, MindFrame operates as a subsidiary of Covidien plc.

Altura Medical, Inc. is a medical device company based in Menlo Park, California, focused on developing advanced endograft technology for the treatment of abdominal aortic aneurysms (AAA) and related conditions. The company's primary product is the Agili-D AAA System, an innovative endovascular aneurysm repair technology designed to improve patient outcomes. Founded in 2008, Altura Medical has garnered support from a notable group of venture capital investors and is led by a seasoned management team. The company operates as a subsidiary of Lombard Medical, Inc. as of July 2015.

AqueSys, Inc. is an ophthalmic company based in Aliso Viejo, California, specializing in the development and commercialization of innovative implantable devices for glaucoma treatment. Founded in 2005, the company is known for its XEN gel stent, which facilitates the outflow of aqueous fluid from the anterior chamber to the subconjunctival space, effectively lowering intraocular pressure. This device creates a new drainage pathway, enhancing patient outcomes in glaucoma management. AqueSys operates as a subsidiary of Allergan plc, focusing on advancing surgical solutions to improve eye health.

EBR Systems, Inc. is focused on developing innovative implantable devices for cardiac rhythm management, specifically aimed at treating patients with heart failure and cardiac arrhythmias. The company's flagship product, the Wireless Cardiac Stimulation of the Left Ventricle System, utilizes proprietary wireless technology to provide endocardial pacing for cardiac resynchronization therapy. This approach enhances the heart's pumping efficiency by synchronizing the contractions of the left and right ventricles. Founded in 2003 and headquartered in Sunnyvale, California, EBR Systems is committed to advancing therapeutic options for patients suffering from cardiac rhythm diseases through its novel technologies.

Entellus Medical, doing business as Stryker ENT, is a medical device company based in Plymouth, Minnesota, specializing in innovative solutions for ear, nose, and throat (ENT) treatments. Founded in 2006, Entellus develops and commercializes minimally invasive products aimed at addressing chronic sinusitis, eustachian tube dysfunction, and nasal airway obstruction. Its product lineup includes the XprESS ENT dilation system, which offers versatility for sinus and eustachian tube procedures, and the FinESS Sinus Treatment, a direct and effective method for treating chronic rhinosinusitis that minimizes invasiveness and recovery time. The company also provides a range of surgical instruments, imaging solutions, and other tools that enhance patient care while reducing discomfort and the need for general anesthesia. By collaborating with researchers and clinicians, Entellus Medical works to meet the unmet needs of physicians and patients alike, thereby improving treatment outcomes in the ENT field.

Asensus Surgical is a medical device company focused on enhancing minimally invasive surgery through digital laparoscopy. By digitizing the interface between surgeons and patients, the company incorporates advanced technologies such as augmented intelligence, connectivity, and robotics into surgical procedures. Their flagship product, the Senhance Surgical System, is notable for being the first machine vision system designed for robotic surgery. This system is supported by the Intelligent Surgical Unit, which facilitates augmented intelligence in surgery. Asensus Surgical aims to address various clinical, cognitive, and economic challenges faced in surgical practices, ultimately improving patient outcomes through innovative solutions in digital laparoscopy.

ValenTx, Inc. is a medical device company based in Maple Grove, Minnesota, established in 2002. It specializes in developing minimally invasive therapy solutions aimed at treating obesity and its related metabolic disorders, including type-2 diabetes and hypertension. One of its key innovations is an endoluminal bypass therapy that replicates the anatomical changes associated with the Roux-en-Y gastric bypass procedure using an adjustable, removable, and replaceable device. ValenTx's focus is on providing effective treatment options for individuals struggling with morbid obesity and related health issues.

Spinal Kinetics LLC is a medical device company based in Sunnyvale, California, dedicated to developing non-fusion motion preservation systems for treating degenerative diseases of the spine. Founded in 2003, the company offers two primary products: the M6-C artificial cervical disc and the M6-L artificial lumbar disc, both designed to replicate the anatomical and biomechanical characteristics of natural intervertebral discs. These innovations provide options for artificial disc replacement in the cervical and lumbar regions. Spinal Kinetics collaborates with spine surgeons to ensure that its products meet clinical needs and are sold through a network of distributors across various countries, including Australia, Germany, the United Kingdom, and the United Arab Emirates. The company operates as a subsidiary of Orthofix Medical Inc.

Altura Medical, Inc. is a medical device company based in Menlo Park, California, focused on developing advanced endograft technology for the treatment of abdominal aortic aneurysms (AAA) and related conditions. The company's primary product is the Agili-D AAA System, an innovative endovascular aneurysm repair technology designed to improve patient outcomes. Founded in 2008, Altura Medical has garnered support from a notable group of venture capital investors and is led by a seasoned management team. The company operates as a subsidiary of Lombard Medical, Inc. as of July 2015.

NovaLign Orthopaedics formerly known as OsteoLign is an orthopaedic medical device company based in Memphis, Tenn. NovaLign recently received its first 510(k) clearance from the FDA to market its new Intramedullary Fixation System, a new system of implants and instruments for the treatment of long bone fractures, including the humerus, tibia and femur.

LensX Lasers is a developer of surgical lasers used for the reparation of cataracts.

Concentric Medical, based in Mountain View, California, is a medical device company dedicated to creating minimally invasive technologies for the neurovascular system. The firm specializes in developing endovascular devices aimed at revascularizing patients who have suffered ischemic strokes. Its product line includes devices designed to restore blood flow by effectively removing blood clots from the brain's vasculature, as well as Merci microcatheters that facilitate navigation through the vascular system to reach the affected areas.

Cellutions is developing proprietary medical devices and procedures to treat cellulite, a condition that affects 90% of post-adolescent females. The company is developing a proprietary technology/procedure to be performed in an outpatient setting as a minimally invasive ‘lunchtime' treatment.

Altura Medical, Inc. is a medical device company based in Menlo Park, California, focused on developing advanced endograft technology for the treatment of abdominal aortic aneurysms (AAA) and related conditions. The company's primary product is the Agili-D AAA System, an innovative endovascular aneurysm repair technology designed to improve patient outcomes. Founded in 2008, Altura Medical has garnered support from a notable group of venture capital investors and is led by a seasoned management team. The company operates as a subsidiary of Lombard Medical, Inc. as of July 2015.

AqueSys, Inc. is an ophthalmic company based in Aliso Viejo, California, specializing in the development and commercialization of innovative implantable devices for glaucoma treatment. Founded in 2005, the company is known for its XEN gel stent, which facilitates the outflow of aqueous fluid from the anterior chamber to the subconjunctival space, effectively lowering intraocular pressure. This device creates a new drainage pathway, enhancing patient outcomes in glaucoma management. AqueSys operates as a subsidiary of Allergan plc, focusing on advancing surgical solutions to improve eye health.

AlloCure, Inc. is a biotechnology company focused on developing cell therapies for kidney diseases and related conditions. Founded in 2006 and based in Burlington, Massachusetts, with additional operations in Salt Lake City, Utah, and Hamburg, Germany, the company specializes in biologic therapies for acute kidney injuries and other serious illnesses. Central to AlloCure's approach is its unique technology that utilizes processed cells derived from human bone marrow, aiming to create off-the-shelf biological treatments for a range of debilitating diseases. The company was established based on the proprietary research of renowned scientists Dr. Christof Westenfelder and Dr. Axel Zander, who have dedicated their careers to advancing effective therapies for kidney-related ailments.

EBR Systems, Inc. is focused on developing innovative implantable devices for cardiac rhythm management, specifically aimed at treating patients with heart failure and cardiac arrhythmias. The company's flagship product, the Wireless Cardiac Stimulation of the Left Ventricle System, utilizes proprietary wireless technology to provide endocardial pacing for cardiac resynchronization therapy. This approach enhances the heart's pumping efficiency by synchronizing the contractions of the left and right ventricles. Founded in 2003 and headquartered in Sunnyvale, California, EBR Systems is committed to advancing therapeutic options for patients suffering from cardiac rhythm diseases through its novel technologies.

Entellus Medical, doing business as Stryker ENT, is a medical device company based in Plymouth, Minnesota, specializing in innovative solutions for ear, nose, and throat (ENT) treatments. Founded in 2006, Entellus develops and commercializes minimally invasive products aimed at addressing chronic sinusitis, eustachian tube dysfunction, and nasal airway obstruction. Its product lineup includes the XprESS ENT dilation system, which offers versatility for sinus and eustachian tube procedures, and the FinESS Sinus Treatment, a direct and effective method for treating chronic rhinosinusitis that minimizes invasiveness and recovery time. The company also provides a range of surgical instruments, imaging solutions, and other tools that enhance patient care while reducing discomfort and the need for general anesthesia. By collaborating with researchers and clinicians, Entellus Medical works to meet the unmet needs of physicians and patients alike, thereby improving treatment outcomes in the ENT field.

CardioMind, Inc. Inc manufactures therapeutic devices for cardiovascular diseases. The company also offers stent delivery systems, which are designed for use in lesion applications, as well as for the treatment of coronary and peripheral artery diseases. In addition, it provides invasive endovascular medical devices for treating neurological and cardiovascular diseases. The company was founded in 2003 and is based in Sunnyvale, California.

Asensus Surgical is a medical device company focused on enhancing minimally invasive surgery through digital laparoscopy. By digitizing the interface between surgeons and patients, the company incorporates advanced technologies such as augmented intelligence, connectivity, and robotics into surgical procedures. Their flagship product, the Senhance Surgical System, is notable for being the first machine vision system designed for robotic surgery. This system is supported by the Intelligent Surgical Unit, which facilitates augmented intelligence in surgery. Asensus Surgical aims to address various clinical, cognitive, and economic challenges faced in surgical practices, ultimately improving patient outcomes through innovative solutions in digital laparoscopy.

AqueSys, Inc. is an ophthalmic company based in Aliso Viejo, California, specializing in the development and commercialization of innovative implantable devices for glaucoma treatment. Founded in 2005, the company is known for its XEN gel stent, which facilitates the outflow of aqueous fluid from the anterior chamber to the subconjunctival space, effectively lowering intraocular pressure. This device creates a new drainage pathway, enhancing patient outcomes in glaucoma management. AqueSys operates as a subsidiary of Allergan plc, focusing on advancing surgical solutions to improve eye health.

CardioMind, Inc. Inc manufactures therapeutic devices for cardiovascular diseases. The company also offers stent delivery systems, which are designed for use in lesion applications, as well as for the treatment of coronary and peripheral artery diseases. In addition, it provides invasive endovascular medical devices for treating neurological and cardiovascular diseases. The company was founded in 2003 and is based in Sunnyvale, California.

Cellutions is developing proprietary medical devices and procedures to treat cellulite, a condition that affects 90% of post-adolescent females. The company is developing a proprietary technology/procedure to be performed in an outpatient setting as a minimally invasive ‘lunchtime' treatment.

Entellus Medical, doing business as Stryker ENT, is a medical device company based in Plymouth, Minnesota, specializing in innovative solutions for ear, nose, and throat (ENT) treatments. Founded in 2006, Entellus develops and commercializes minimally invasive products aimed at addressing chronic sinusitis, eustachian tube dysfunction, and nasal airway obstruction. Its product lineup includes the XprESS ENT dilation system, which offers versatility for sinus and eustachian tube procedures, and the FinESS Sinus Treatment, a direct and effective method for treating chronic rhinosinusitis that minimizes invasiveness and recovery time. The company also provides a range of surgical instruments, imaging solutions, and other tools that enhance patient care while reducing discomfort and the need for general anesthesia. By collaborating with researchers and clinicians, Entellus Medical works to meet the unmet needs of physicians and patients alike, thereby improving treatment outcomes in the ENT field.

Quick Study Radiology provides digital imaging solutions for community hospitals, radiology and oncology practices, and imaging centers. The company offers image and data archiving, and disaster recovery services; monitoring and security services; and networking and web distribution services. It also provides picture archiving and communication systems for community hospitals and other facilities, and radiology information systems to store, manage, and distribute patient’s data and imagery. Quick Study Radiology was founded in 1999 and is based in Saint Louis, Missouri.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to restore near vision for presbyopic patients while preserving distance vision. Additionally, AcuFocus develops the IC-8 IOL, a small aperture lens that facilitates a range of vision for patients with cataracts. The AcuTarget HD is another key product, serving as a diagnostic and surgical planning instrument for various vision correction procedures, including LASIK and cataract surgeries. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, addressing the needs of both physicians and patients in the vision care sector. Founded in 2001, AcuFocus continues to focus on innovative solutions for vision-related challenges.

Neurotech is a privately held biotechnology company focused on developing innovative therapies for chronic retinal diseases, addressing significant unmet medical needs in the ophthalmology market. The company has created a novel ocular implant that facilitates the continuous production of therapeutic proteins directly in the eye. This system is designed to help therapeutic cells survive in challenging conditions, thereby replacing or supporting the function of deteriorating target cells or tissues. By enhancing the treatment options available for eye diseases, Neurotech aims to improve the quality of life for patients suffering from these conditions.

Entellus Medical, doing business as Stryker ENT, is a medical device company based in Plymouth, Minnesota, specializing in innovative solutions for ear, nose, and throat (ENT) treatments. Founded in 2006, Entellus develops and commercializes minimally invasive products aimed at addressing chronic sinusitis, eustachian tube dysfunction, and nasal airway obstruction. Its product lineup includes the XprESS ENT dilation system, which offers versatility for sinus and eustachian tube procedures, and the FinESS Sinus Treatment, a direct and effective method for treating chronic rhinosinusitis that minimizes invasiveness and recovery time. The company also provides a range of surgical instruments, imaging solutions, and other tools that enhance patient care while reducing discomfort and the need for general anesthesia. By collaborating with researchers and clinicians, Entellus Medical works to meet the unmet needs of physicians and patients alike, thereby improving treatment outcomes in the ENT field.

Spinal Kinetics LLC is a medical device company based in Sunnyvale, California, dedicated to developing non-fusion motion preservation systems for treating degenerative diseases of the spine. Founded in 2003, the company offers two primary products: the M6-C artificial cervical disc and the M6-L artificial lumbar disc, both designed to replicate the anatomical and biomechanical characteristics of natural intervertebral discs. These innovations provide options for artificial disc replacement in the cervical and lumbar regions. Spinal Kinetics collaborates with spine surgeons to ensure that its products meet clinical needs and are sold through a network of distributors across various countries, including Australia, Germany, the United Kingdom, and the United Arab Emirates. The company operates as a subsidiary of Orthofix Medical Inc.

Confluent Surgical develops products to address the need for surgical sealing and post-surgical adhesion prevention applications.The company provides DuraSeal, an adjunct to sutured dural repair during cranial surgeries to provide watertight closure. The company was founded in 1998 and is headquartered in Waltham, Massachusetts.

CHF Solutions is a medical device manufacturer based in Brooklyn Park, Minnesota, focused on developing innovative therapies for cardiac care. Founded in 1998, the company specializes in aquapheresis therapy and fluid removal systems, particularly the Aquadex FlexFlow system, which is designed to treat fluid-overloaded patients. By effectively removing excess salt and water, these devices assist physicians in managing patients with heart failure and related conditions, addressing significant clinical needs within the healthcare sector.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to restore near vision for presbyopic patients while preserving distance vision. Additionally, AcuFocus develops the IC-8 IOL, a small aperture lens that facilitates a range of vision for patients with cataracts. The AcuTarget HD is another key product, serving as a diagnostic and surgical planning instrument for various vision correction procedures, including LASIK and cataract surgeries. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, addressing the needs of both physicians and patients in the vision care sector. Founded in 2001, AcuFocus continues to focus on innovative solutions for vision-related challenges.

PowderMed developed vaccines for the treatment of chronic infectious diseases and cancer. The company used DNA coated gold particles delivered by a needle-free injection device to stimulate a powerful and specific T cell immune response.

Insulet Corporation, established in 2000, specializes in the development, manufacturing, and sale of insulin delivery systems for individuals with insulin-dependent diabetes. Its flagship product, the Omnipod System, comprises a self-adhesive, disposable, and tubeless device worn on the body for up to three days, along with a wireless, handheld personal diabetes manager. The company primarily sells its products through independent distributors, pharmacies, and directly to patients, with a presence in the United States, Canada, Europe, and the Middle East. Insulet's mission is to enhance the lives of people with diabetes by providing a user-friendly, pain-free, and automated insulin delivery solution.

Eunoe, Inc. is a San Francisco Bay-area medical device company focused on the treatment of neurological disorders through the management of cerebrospinal fluid.

LipoSonix, Inc. operates as a medical device company. The company develops non-invasive body sculpting products for aesthetic applications. The company was founded in 1999 and is based in Bothell, Washington. As of July 1, 2008, LipoSonix, Inc. operates as a subsidiary of Medicis Pharmaceutical Corp.

Insulet Corporation, established in 2000, specializes in the development, manufacturing, and sale of insulin delivery systems for individuals with insulin-dependent diabetes. Its flagship product, the Omnipod System, comprises a self-adhesive, disposable, and tubeless device worn on the body for up to three days, along with a wireless, handheld personal diabetes manager. The company primarily sells its products through independent distributors, pharmacies, and directly to patients, with a presence in the United States, Canada, Europe, and the Middle East. Insulet's mission is to enhance the lives of people with diabetes by providing a user-friendly, pain-free, and automated insulin delivery solution.

MicroMed Technology specializes in medical devices focused on cardiac support, particularly through its innovative MicroMed DeBakey VAD®, developed in collaboration with prominent medical professionals and NASA. This device, which weighs less than four ounces and is significantly smaller and quieter than traditional ventricular assist devices, serves as a critical solution for patients awaiting heart transplants. It aims to enhance cardiac output for individuals with failing hearts, offering a less invasive and cost-effective alternative to larger, pulsatile devices currently available in the market. The MicroMed DeBakey VAD® has the potential to improve the quality of life for thousands of patients in the United States who could benefit from heart transplants.

BioClinica, Inc. is a prominent global provider of integrated clinical trial management services, specializing in technology-enhanced solutions for pharmaceutical and medical device innovation. The company offers a range of services, including imaging core lab support, electronic data capture, patient recruitment, and clinical supply chain optimization, all designed to improve efficiency and manageability throughout the clinical trial process. With over 20 years of experience and a portfolio of more than 2,000 successful trials, BioClinica has played a significant role in the clinical development of new medicines from early phases to final approval. The company operates advanced, regulatory-compliant imaging core labs across two continents and provides comprehensive eClinical and data management services from its offices in the United States, Europe, and Asia.

CardioFocus, Inc. is a biotechnology company based in Marlborough, Massachusetts, that specializes in the development of innovative medical devices for the treatment of cardiac disorders, particularly atrial fibrillation. The company offers a range of products, including the HeartLight Endoscopic Ablation System, which utilizes visually guided laser balloon technology to achieve precise pulmonary vein isolation. This system is complemented by the HeartLight Excalibur Balloon, designed for stable contact and effective lesion creation through direct tissue visualization, and the HeartLight X3 System, which allows for controlled lesion formation. CardioFocus focuses on providing electrophysiologists with advanced tools that enhance the precision and control of ablation treatments, utilizing disposable fiber optic catheters for improved visualization of cardiac anatomy and the treatment of arrhythmias. Founded in 1990, CardioFocus continues to pursue advancements in ablation technologies to better meet the needs of patients and healthcare providers.