Theodorus III

Simmunome is a biotechnology company that operates as a contract research organization, specializing in the development of artificial intelligence-driven computational models. These models focus on the pathogenesis and immunogenesis of various diseases, particularly in oncology and the nervous system. By thoroughly annotating cellular interactions at a molecular level, Simmunome achieves high physiological accuracy in its models. The company addresses the inefficiencies associated with clinical trial success by transforming physiological systems into biologically representative simulations. Utilizing machine learning and integrating multi-omic data, Simmunome enhances the predictive accuracy of its models, allowing drug discovery and research organizations to better understand drug mechanisms, improve efficacy in targeted populations, and assess safety profiles effectively.

Flare Systems Inc is a Montreal-based company that specializes in developing cybersecurity tools aimed at helping financial institutions protect their data from cybercriminals. Founded in 2017, the company offers a dark net monitoring system that provides intelligence to information security and fraud management teams within banks. By aggregating data from various sources, including broadcasts of stolen information, private forum discussions, chat posts, and cryptocurrency transactions, Flare's platform delivers actionable insights that assist financial crime teams in identifying and mitigating security threats. Its technology enables organizations to monitor activities across threat landscapes and connect the chains of attack, such as phishing and money laundering, thereby preventing cyber attacks before they result in costly data breaches.

Domain Therapeutics SA is a biopharmaceutical company based in Illkirch-Graffenstaden, France, focused on the discovery and early development of therapeutic drugs targeting G protein-coupled receptors (GPCRs), which are key drug targets in various diseases. Founded in 2001, the company specializes in developing small molecules for the treatment of central nervous system (CNS) disorders and cancer. It employs its proprietary technology platform, DTect-All, which enables the identification of orthosteric and allosteric ligands, including Silent Allosteric Modulators (SAMs) that are challenging to discover using conventional methods. In addition, Domain Therapeutics offers BioSens-All, a platform to explore the signaling complexities associated with GPCR activation, enhancing its ability to address difficult targets, such as orphan and peptidic GPCRs.

DrugBank is a developer of a comprehensive drug knowledge platform aimed at enhancing healthcare delivery and accelerating drug research. Their robust database provides extensive information on pharmaceuticals, including mechanisms of action, drug interactions, and allergy information, which empowers healthcare professionals to make informed decisions. The platform includes tools for drug search, interaction checking, and access to drug labels, facilitating precision medicine and clinical software applications. By integrating these resources into various software solutions via their API, DrugBank enables companies to scale their usage and expedite the development of novel drug candidates and predictive machine learning models. Additionally, DrugBank Online offers a free-to-use resource with limited datasets for academic and non-commercial research, contributing to its recognition in over 13,000 academic publications and its widespread use among millions of researchers and health professionals worldwide.

Cascador Health is a developer of a healthcare data platform that aims to enhance the quality of healthcare by connecting data providers with the research industry. The company's platform offers access to structured, validated, and anonymized real-world data, facilitating insights into therapeutic outcomes and improving site selection for clinical studies. Additionally, it enables the monitoring of safety and adverse effects in healthcare settings, as well as the optimization of processes within hospitals. Through these capabilities, Cascador Health assists healthcare providers and clients in the life sciences industry in making informed decisions to improve patient care and outcomes.

Hypno VR SAS is a company that specializes in developing and operating virtual reality-based medical hypnosis solutions aimed at managing pain and stress. Founded in 2016 and headquartered in Strasbourg, France, Hypno VR creates applications designed to facilitate medical hypnosis during procedures, thereby reducing anxiety and discomfort for patients. The company's technology is particularly beneficial in various medical fields, including pediatric surgery, gastroenterology, gynecology, and dental surgery. In addition to its software solutions, Hypno VR also develops virtual reality hardware tailored for medical applications, catering to health professionals and institutions seeking innovative ways to enhance patient care.

Giiant Pharma is a preclinical-stage biotechnology company focused on developing innovative therapies for inflammatory bowel diseases (IBD). Utilizing its proprietary Precision Delivery technology platform, Giiant designs gut-restricted, tissue-specific small molecule drug therapeutics that target various biological mechanisms in gastroenterology. The company's lead program, GT-2108, is a microbiota-activated PDE4 inhibitor prodrug that aims to enhance drug tolerability and improve therapeutic outcomes. By releasing the active form of the drug specifically in the colon at the site of inflammation, Giiant's approach seeks to provide safer and more effective treatment options for patients suffering from IBD.

Classcraft is an online educational role-playing game designed to enhance classroom management and engage students in the learning process. Founded by Lauren Young, Devin Young, and Shawn Young, the platform offers a gamified experience that motivates learners by promoting teamwork and personal growth. It enables educators to foster positive student behavior through interactive gameplay, where students can earn rewards and develop skills that reflect real-world consequences. Classcraft is accessible across multiple platforms, including Android, iOS, OS X, Chrome, and Windows, making it a versatile tool for teachers and administrators aiming to create a more dynamic and engaging educational environment.

ChromaCure is a biotechnology company focused on developing innovative cancer therapies. The company specializes in discovering first-in-class small molecule therapeutics that address unmet needs in oncology. ChromaCure's primary goal is to identify potential new drug candidates that selectively and potently inhibit cancer targets, offering novel treatment options for various forms of cancer. These therapies are designed to be used either as monotherapy or in combination with existing treatments such as immunotherapy or chemotherapy, aiming to provide more effective solutions for cancer patients.

VIRTEO NV is a Belgian company founded in 2013 and headquartered in Mechelen. It operates a Software as a Service (SaaS) platform designed to facilitate the recovery of unpaid invoices for various clients, including corporations, small and medium-sized enterprises (SMEs), public institutions, court bailiffs, and lawyers. The platform streamlines internal dunning and external debt collection processes, enabling creditors to work efficiently with their partners while maintaining transparency and compliance. By offering tools that help manage the practices of external collection agencies, VIRTEO empowers clients to adhere to socially responsible policies while improving recovery rates and reducing costs. The company's approach aims to balance the goals of financial recovery with ethical standards, enhancing the reputation of the debt collection industry.

PharmaFluidics is a Brussels-based spin-off from the Vrije Universiteit Brussel, focusing on developing and manufacturing micro-chip based chromatography columns for use in biomarker, diagnostics, and drug research applications. The company leverages its expertise in chemical engineering and micro-fabrication technology to create high-quality solutions tailored for mixing, separation, and reaction processes at milli- to nano-scales. Their products enable researchers to identify active compounds in complex biological samples more efficiently and sensitively.

Acar'Up develops and design a trap device designed to extract and kill the allergenic dust mites living in mattresses, chairs, carpets and other upholstered furniture.

X4C specializes in developing advanced monolayer chemical coating technology for a variety of life science applications. The company creates molecular coatings tailored for in vitro diagnostics, medical devices, electronics, and optics. X4C's innovative platform employs a unique approach to surface coating that allows for the precise grafting of robust organic monolayers. This technology enables healthcare professionals to impart specific functionalities to substrates while maintaining their inherent properties. Additionally, X4C offers a range of products, including nanoparticles and calixarenes, along with customized services to meet the diverse needs of its clients in the life sciences sector.

Domobios S.A., established in 2013 and headquartered in Brussels, Belgium, specializes in the development, manufacturing, and sale of products aimed at eradicating domestic pests. The company's primary product, Acar'up, is a user-friendly trap device designed to attract, capture, and eliminate allergenic dust mites found in mattresses, upholstered furniture, and other household items. Domobios offers its products through pharmacies, medical supply stores, and online platforms, both in Belgium and internationally.

Domobios S.A., established in 2013 and headquartered in Brussels, Belgium, specializes in the development, manufacturing, and sale of products aimed at eradicating domestic pests. The company's primary product, Acar'up, is a user-friendly trap device designed to attract, capture, and eliminate allergenic dust mites found in mattresses, upholstered furniture, and other household items. Domobios offers its products through pharmacies, medical supply stores, and online platforms, both in Belgium and internationally.

Ovizio is a company that specializes in digital holographic interferometric microscopy products, particularly focusing on the development of automated systems for cell culture monitoring and analysis. Its innovative technology enables the creation of four-dimensional microscopic imaging devices and accompanying software, specifically designed to assist scientists and biomanufacturers in optimizing and scaling their cell culture processes. By targeting the life sciences bio-processing segment and the research and development market, Ovizio aims to enhance the efficiency and effectiveness of scientific endeavors in these fields.

CluePoints Inc. is a developer of cloud-based risk-based quality management and monitoring software tailored for the pharmaceutical industry and contract research organizations. Established in 2012 and headquartered in King of Prussia, Pennsylvania, with an additional office in Louvain-la-Neuve, Belgium, CluePoints specializes in risk-based monitoring and central statistical monitoring solutions. Over its 15 years of development, the company has refined its software to utilize unique statistical algorithms that assess the quality, accuracy, and integrity of clinical trial data throughout the study lifecycle. The company's solutions are designed to identify and address anomalous data and site errors, thereby enhancing clinical data quality, optimizing on-site monitoring, and reducing regulatory submission risks. CluePoints' offerings align with guidelines from international regulatory bodies, supporting traditional monitoring and enabling a proactive risk-based monitoring strategy.

neoScores is an innovative company based in Kontich, Belgium, that specializes in providing an online platform for purchasing and playing digital sheet music. Established in 2013 by three professional musicians—Bart Van der Roost, Bob Hamblok, and Jonas Coomans—the company aims to transform the way musicians access and utilize sheet music. The platform, known as Gustaf, is compatible across various operating systems and devices, enabling users to securely buy scores and share notes with fellow musicians from anywhere. With a focus on high-quality, flexible, and aesthetically pleasing digital scores, neoScores strives to enhance the musical experience for users, allowing them to engage with music seamlessly via smartphones, tablets, or computers.

PharmaFluidics is a Brussels-based spin-off from the Vrije Universiteit Brussel, focusing on developing and manufacturing micro-chip based chromatography columns for use in biomarker, diagnostics, and drug research applications. The company leverages its expertise in chemical engineering and micro-fabrication technology to create high-quality solutions tailored for mixing, separation, and reaction processes at milli- to nano-scales. Their products enable researchers to identify active compounds in complex biological samples more efficiently and sensitively.