Unorthodox Ventures

Supira Medical, Inc. is a medical device company that specializes in developing a percutaneous ventricular assist device (pVAD) aimed at high-risk patients undergoing interventional procedures. This innovative device provides temporary mechanical support to assist the heart's native pumping action, making it a critical solution for patients facing severe coronary artery disease or cardiogenic shock during coronary interventions. The company's technology is designed to facilitate recovery in patients who require urgent mechanical support, thereby enhancing their ability to undergo necessary medical procedures. Founded in 2012 and based in Campbell, California, Supira Medical was previously known as Lumenblation Medical, Inc. before rebranding in March 2016.

Laplace Interventional is a medical device company focused on developing transcatheter tricuspid valve technology aimed at treating tricuspid regurgitation. The company's innovative prosthetic valve is delivered through a minimally invasive procedure, eliminating the need for open-heart surgery. This approach not only enhances patients' life expectancy but also significantly improves their quality of life by reducing the risk of future complications. Through its advancements in cardiac care, Laplace Interventional is dedicated to providing effective solutions for patients worldwide.

Sonavex, Inc. is a Baltimore-based company founded in 2013 that specializes in advanced imaging technology aimed at enhancing surgical outcomes. The company has developed a proprietary ultrasound-based platform that enables clinicians to detect anastomotic blood clots and assess critical intravascular flow metrics directly at the point of care. This technology not only facilitates the measurement of blood flow and vessel morphology but also includes bioresorbable and echogenic equipment to mark at-risk blood vessels for future assessments. By providing actionable data, Sonavex supports healthcare providers in monitoring and improving patient care, particularly in the context of post-operative complications.

CorFlow Therapeutics is a medtech startup that develops proprietary technologies for diagnosis and treatment of microvascular obstructions in heart attack patients. The CorFlow technologies enable interventional cardiologists to diagnose and treat MVO in severe heart attack patients thereby potentially reducing the short- and long-term complication rates in these patients.

Adona Medical is a privately held company focused on developing innovative interventional solutions for heart failure, a condition that affects around 6.5 million patients in the United States and approximately 26 million worldwide. The company's heart failure management system is designed for personalized care, utilizing advanced sensor and shunt technologies to enhance the standard of heart care. By implementing interatrial shunt technology, Adona Medical aims to improve the understanding of a patient's hemodynamic status, allowing healthcare providers to tailor treatments to individual needs and ultimately enhance patient outcomes in managing heart failure.

Firmus develops an artificial intelligence-based software solution tailored for the construction industry, focusing on the identification and prevention of design errors. The software analyzes construction models and rationalizes issues derived from numerous reports, presenting prioritized feedback based on cost and complexity. This enables construction companies to learn from past mistakes, reduce risk, and optimize their methods. Additionally, Firmus provides an intelligent issue tracking interface that facilitates effective communication among team members and seamlessly integrates with existing workflows, enhancing overall project coordination and efficiency.

ConKay Medical Systems is an early-stage medical device company advancing solutions to treat valvular regurgitation in patients with progressive heart failure.

Laza Medical is a privately held startup that specializes in the development of AI-powered robotic imaging solutions for cardiovascular treatments. The company aims to enhance the quality of imaging in cardiac interventions by integrating advanced artificial intelligence software with robotic technology. This innovative approach is designed to optimize procedural workflows and improve the standard of imaging for cardiovascular procedures. By providing a user-friendly interface, Laza Medical seeks to make high-quality imaging and advanced procedural navigation accessible to a wide range of clinicians, ultimately enhancing patient care in the field of cardiovascular medicine.

Corporis Medical is a medical device company focused on developing and commercializing innovative diagnostic tools for minimally invasive surgical procedures, particularly in laparoscopic and bowel surgery. The company aims to enhance surgical outcomes by preventing anastomotic leakages, allowing surgeons to assess the quality of the anastomosis during operations. By improving surgical techniques and outcomes, Corporis Medical contributes to reducing postoperative complications and lowering overall healthcare costs.

Supira Medical, Inc. is a medical device company that specializes in developing a percutaneous ventricular assist device (pVAD) aimed at high-risk patients undergoing interventional procedures. This innovative device provides temporary mechanical support to assist the heart's native pumping action, making it a critical solution for patients facing severe coronary artery disease or cardiogenic shock during coronary interventions. The company's technology is designed to facilitate recovery in patients who require urgent mechanical support, thereby enhancing their ability to undergo necessary medical procedures. Founded in 2012 and based in Campbell, California, Supira Medical was previously known as Lumenblation Medical, Inc. before rebranding in March 2016.

Akura Medical is focused on developing innovative medical devices aimed at improving the process of thrombectomy, specifically through a next-generation device designed for easy use in a single-pass procedure to efficiently remove blood clots. The company specializes in thrombectomy devices and also offers a range of surgical, medical, dental, and veterinary instruments. By providing effective solutions for clot removal, Akura Medical enables healthcare professionals to better address critical needs and treat venous thromboembolism of varying sizes.

KEWAZO GmbH, founded in 2016 and based in Gilching, Germany, specializes in developing robotic systems for the construction industry, specifically aimed at enhancing material transport for scaffolding companies and industrial service providers. The company's flagship product, the robotic material hoist LIFTBOT, automates the flow of materials both vertically and horizontally on construction sites, significantly reducing labor costs and addressing labor shortages while improving safety. By integrating these robotic platforms on-site, KEWAZO not only facilitates just-in-time and just-in-place delivery of scaffolding parts during assembly but also collects operational data. This data is made available to clients through a comprehensive analytics platform, enabling more proactive management of projects and overall company operations.

Lumen is a company that has developed a portable device and accompanying app designed to measure metabolism through a simple breath test. This innovative technology provides users with daily personalized nutrition guidance based on their metabolic data, helping them achieve various health and fitness goals such as weight loss, performance optimization, and improved metabolic health. The device functions as a real-time breathalyzer that allows individuals to understand their metabolic trends and make informed decisions about their dietary habits. With a focus on enhancing personal health through metabolic insights, Lumen aims to change how people approach nutrition and body management. The team comprises scientists, researchers, engineers, and designers dedicated to making metabolism more accessible and understandable for everyone.

SafKan, Inc. is a medical device company based in Tucson, Arizona, focused on developing and manufacturing automated ear cleaning solutions for clinical applications. Founded in 2016, the company offers the OtoSet, an FDA-cleared and wearable device designed to facilitate mess-free earwax removal. With approximately 35 million Americans affected by impacted earwax, which can lead to conductive hearing loss, the OtoSet provides a safe and effective method for addressing mild to severe earwax impactions. The device employs hygienic disposable ear tips and waste containers, allowing for both bilateral and unilateral procedures, enhancing patient comfort and ensuring a streamlined process for healthcare providers.

Zippsafe AG is a technology company that specializes in space-efficient storage solutions. It focuses on the development, manufacture, and installation of innovative lockable closing bags designed for changing rooms and public spaces. By utilizing a flexible, smart fabric-based locker system, Zippsafe's self-service wardrobe systems provide an effective alternative to traditional sheet metal lockers. This design not only enhances efficiency but also maximizes available space, making it particularly beneficial for event organizers, conference centers, and warehouse owners. Through its products, Zippsafe aims to help clients reduce costs and increase occupancy in various settings.

DiaMonTech AG is a medical technology company based in Berlin, Germany, focused on developing non-invasive diagnostic devices for blood glucose monitoring. Founded in 2015, the company utilizes a proprietary laser-based photo-thermal detection technology to measure glucose levels without the need for blood draws or finger pricking, thereby offering a painless alternative for diabetes management. DiaMonTech's product lineup includes the D-BASE, a device designed for human trials, the D-pocket, a compact personal device for frequent glucose tracking, and the D-BAND, a wearable device that continuously monitors blood sugar levels. Through its innovative solutions, DiaMonTech aims to enhance the quality of life for individuals managing diabetes.

Awkward Essentials is a company based in San Jose, Costa Rica, founded in 2013. It specializes in a single product known as the Dripstick, which is designed for post-sex cleanup. This innovative product features a super soft, medical-grade sponge that effectively absorbs excess fluids, promoting personal hygiene in a convenient manner. The Dripstick's unique material allows for a comfortable experience while ensuring quick and efficient cleanup, catering to the needs of users seeking a hassle-free solution for maintaining cleanliness after sexual intercourse.

Vibrant Gastro is a company focused on developing and producing a chemical-free vibrating capsule designed to treat constipation. The innovative capsule aims to address the fundamental physiological aspects of constipation, promoting natural bowel activity without relying on chemical supplements or disrupting the body’s internal balance. Leveraging extensive knowledge in gastrointestinal health and motility, Vibrant Gastro offers a novel solution for individuals seeking effective relief from constipation while maintaining a commitment to chemical-free treatment options.

FitJoy specializes in providing nutritional vegan snacks, focusing on health-conscious consumers. The company offers a variety of gluten-free and GMO-free products, including protein bars and grain-free pretzels, which are free from maltitol, artificial colors, flavors, sweeteners, and preservatives. Designed with the conscious consumer in mind, FitJoy aims to simplify healthy eating while promoting wellness. Additionally, through its Joy Forward initiative, a portion of the proceeds from each purchase supports efforts to feed underprivileged children in the United States, highlighting the brand's commitment to social responsibility.

Afia provides a variety bundle, a vegan bundle, traditional kibbeh, traditional falafel, za'atar falafel, garlic, and herb afia falafel. mediterranean, gluten free, vegan, plant-based, non-GMO, turmeric falafel, sun-dried tomato falafel, and three cheese falafel products.

Shotgun Seltzer delivers a craft quality and crisp taste that’s completely unique classic cocktails.

Lumen is a company that has developed a portable device and accompanying app designed to measure metabolism through a simple breath test. This innovative technology provides users with daily personalized nutrition guidance based on their metabolic data, helping them achieve various health and fitness goals such as weight loss, performance optimization, and improved metabolic health. The device functions as a real-time breathalyzer that allows individuals to understand their metabolic trends and make informed decisions about their dietary habits. With a focus on enhancing personal health through metabolic insights, Lumen aims to change how people approach nutrition and body management. The team comprises scientists, researchers, engineers, and designers dedicated to making metabolism more accessible and understandable for everyone.

TUSHY LLC is a company that manufactures and markets bidet toilet attachments designed to enhance personal hygiene while promoting environmental sustainability. Founded in 2014 and headquartered in Brooklyn, New York, TUSHY aims to revolutionize bathroom experiences by providing a product that attaches to standard toilets and utilizes water for an effective cleaning method, as opposed to traditional toilet paper. This approach not only improves cleanliness but also addresses concerns related to environmental degradation associated with paper products. TUSHY sells its products primarily online, targeting customers in the United States and internationally. The company's focus aligns with its mission to combat the global sanitation crisis while offering a modern solution for personal care.

Unorthodox Ventures is a complete reinvention of the broken and parasitic investment process. Founded by contrarian entrepreneur Carey Smith who bootstrapped Big Ass Fans to a $500 million sale, the company is seeking to partner with founders who demonstrate disruption and discipline. Unlike most investors, Unorthodox Ventures shuns financiers and instead is filled with people who have actually operated companies and know how to grow them.