Unorthodox Ventures

Supira Medical, Inc. is a medical technology company based in Campbell, California, focused on developing a percutaneous ventricular assist device (pVAD) designed for high-risk patients undergoing interventional procedures. This innovative device offers high-flow mechanical support during critical situations such as high-risk percutaneous coronary interventions (PCI) and cardiogenic shock. By assisting the heart's native pumping action, Supira Medical's solution enables patients with severe coronary artery disease or related comorbidities to safely undergo necessary interventions, thereby facilitating quicker recovery from heart-related issues. Founded in 2012 and originally known as Lumenblation Medical, Inc., the company rebranded in March 2016 to reflect its commitment to advancing cardiac care.

Laplace Interventional is a medical device company specializing in the development of transcatheter tricuspid valve technology. This innovative technology aims to enhance life expectancy and improve the quality of life for patients suffering from tricuspid regurgitation. The company's prosthetic valve is delivered through a minimally invasive procedure, eliminating the need for open-heart surgery. By offering a less invasive treatment option, Laplace Interventional enables healthcare providers to mitigate future complications for patients, thereby contributing to a better overall health outcome.

Sonavex, Inc. is a medical technology company based in Baltimore, Maryland, founded in 2013. The company specializes in developing innovative imaging solutions, primarily focusing on ultrasound-based methods to detect anastomotic blood clots and assess vascular health. Sonavex's proprietary technology platform provides clinicians with real-time visualization of critical data at the point of care, enabling them to measure intravascular flow metrics and detect post-operative clots effectively. Additionally, the company has developed bioresorbable and echogenic equipment designed to mark at-risk blood vessels, allowing for future assessments of complications. This technology collects essential data, such as volumetric flow rate and vessel morphology, to enhance patient care in surgical settings, ultimately aiming to improve outcomes for surgical patients.

CorFlow Therapeutics is a medtech startup focused on developing innovative technologies for the diagnosis and treatment of microvascular obstructions in patients experiencing heart attacks. The company has created a controlled flow infusion system that utilizes a proprietary concept to measure microvascular resistance, allowing interventional cardiologists to assess the severity of microvascular obstruction. By comparing these measurements with post-procedure contrast-enhanced magnetic resonance imaging, CorFlow's technology aims to improve the diagnosis and treatment of microvascular obstruction, potentially reducing both short- and long-term complications for severe heart attack patients. Through its advancements, CorFlow is committed to addressing significant unmet medical needs in cardiology.

Adona Medical is a privately held company focused on innovating interventional approaches for heart failure management, a condition affecting approximately 6.5 million patients in the United States and around 26 million globally. The company develops a heart failure management system that enhances the standard of cardiac care through advanced sensor and shunt technologies. This system allows healthcare providers to personalize and tailor treatments for heart failure patients, addressing individual needs more effectively. Adona Medical's interatrial shunt technology provides valuable insights into a patient's hemodynamic status, ultimately aiming to improve care and outcomes for those suffering from this complex and progressive condition.

Firmus develops an artificial intelligence-based software solution tailored for the construction industry, focusing on the identification and prevention of design errors. The software analyzes construction models and rationalizes issues derived from numerous reports, presenting prioritized feedback based on cost and complexity. This enables construction companies to learn from past mistakes, reduce risk, and optimize their methods. Additionally, Firmus provides an intelligent issue tracking interface that facilitates effective communication among team members and seamlessly integrates with existing workflows, enhancing overall project coordination and efficiency.

ConKay Medical Systems is an early-stage medical device company focused on creating innovative solutions for treating valvular regurgitation in patients experiencing progressive heart failure. The company has developed a device that utilizes annular repair technology to address the primary cause of functional regurgitation, preserving the integrity of healthy leaflets to ensure they function as intended. By advancing cardiovascular care, ConKay Medical Systems aims to improve treatment outcomes for patients with this serious condition.

Laza Medical is a privately held startup dedicated to the development of advanced medical imaging solutions specifically for cardiovascular treatments. The company focuses on creating an AI-powered robotic imaging system designed to enhance the quality and efficiency of cardiac interventions. By leveraging artificial intelligence and robotics, Laza Medical aims to optimize procedural workflows and elevate imaging standards in the healthcare sector. Their innovative technology seeks to provide high-quality imaging and improved navigation during procedures, making it accessible to a wide range of clinicians through an intuitive user interface.

Carthera is a clinical-stage medtech company focused on developing innovative ultrasound-based medical devices for treating brain disorders. Its proprietary device, SonoCloud®, is an intracranial ultrasound implant that, when used in conjunction with an intravenous microbubble agent, temporarily opens the blood-brain barrier. This mechanism significantly enhances the delivery of therapeutic molecules to the brain, potentially providing new treatment options for debilitating neurological conditions. Through its technology, Carthera aims to enable healthcare professionals to address challenging brain disorders more effectively.

Corporis Medical is an emerging medical device company dedicated to the development and commercialization of innovative surgical tools. The company specializes in creating diagnostic instruments for minimally invasive procedures, particularly in laparoscopic and bowel surgery. Their products are designed to prevent anastomotic leakages, enabling surgeons to assess the quality of anastomoses in real-time during operations. By improving surgical access and closure, as well as diagnostic measurements, Corporis Medical aims to enhance patient outcomes and reduce postoperative complications, ultimately lowering healthcare costs associated with surgical procedures.

Supira Medical, Inc. is a medical technology company based in Campbell, California, focused on developing a percutaneous ventricular assist device (pVAD) designed for high-risk patients undergoing interventional procedures. This innovative device offers high-flow mechanical support during critical situations such as high-risk percutaneous coronary interventions (PCI) and cardiogenic shock. By assisting the heart's native pumping action, Supira Medical's solution enables patients with severe coronary artery disease or related comorbidities to safely undergo necessary interventions, thereby facilitating quicker recovery from heart-related issues. Founded in 2012 and originally known as Lumenblation Medical, Inc., the company rebranded in March 2016 to reflect its commitment to advancing cardiac care.

Akura Medical develops next-generation thrombectomy devices designed to simplify clot removal with a single-pass procedure, offering an easy-to-use solution to efficiently remove blood clots. The company also provides a range of surgical, medical, dental, and veterinary instruments to support clinicians in addressing venous thromboembolism and other clot-related conditions across diverse patient populations.

KEWAZO GmbH, founded in 2016 and based in Gilching, Germany, specializes in developing robotic systems designed to enhance material transport on construction sites. The company's primary offering, the robotic material hoist LIFTBOT, automates the vertical and horizontal movement of scaffolding components, allowing for safe, just-in-time delivery during assembly. By integrating robotics and data analytics, KEWAZO addresses labor shortages, reduces labor costs by up to 44%, and improves safety on site. Additionally, the company collects operational data from its robotic systems, which is provided to clients through a data analytics platform, facilitating more proactive management of construction projects and overall operations.

Lumen is a company that has developed a portable device and accompanying app that measures an individual's metabolism through a single breath. This technology provides users with real-time insights into their metabolic health, enabling them to receive personalized nutrition recommendations tailored to their unique metabolic data. By using Lumen, individuals can better understand their dietary needs and manage their weight effectively, whether their goals are weight loss, performance optimization, or overall wellness. The company is comprised of a diverse team of scientists, researchers, engineers, and designers dedicated to transforming how people approach their health through improved metabolic awareness.

SafKan Health, founded in 2016 and based in Tucson, Arizona, specializes in the development and manufacturing of automated ear cleaning devices for clinical applications. Its flagship product, OtoSet, is the first automated ear cleaning device to receive FDA clearance, addressing the needs of the 35 million Americans affected by impacted earwax, a common cause of conductive hearing loss. OtoSet offers a hygienic and mess-free solution for earwax removal, featuring disposable ear tips and waste containers. The device is designed to perform both bilateral and unilateral procedures, allowing for effective removal of mild to severe earwax impactions, thereby providing patients with a safe and efficient tool for ear care.

Zippsafe AG is a technology company specializing in innovative storage solutions that prioritize space efficiency. It focuses on the development, manufacturing, and installation of lockable closing bags designed for changing rooms and public spaces. By utilizing a flexible, fabric-based locker system, Zippsafe's self-service wardrobe systems offer a more efficient alternative to traditional metal lockers. This design not only maximizes available space but also provides cost savings and increased occupancy for venues such as event organizers, conference centers, and warehouses. Through its advanced storage solutions, Zippsafe aims to enhance the overall experience in public environments.

DiaMonTech AG is a Berlin-based medical technology company founded in 2015, specializing in the design, development, and commercialization of non-invasive blood glucose monitoring devices. Utilizing proprietary laser-based photo-thermal detection technology, DiaMonTech offers solutions that allow diabetes patients to measure their glucose levels without the pain of finger pricking or the need for blood samples. The company has developed several innovative products, including D-BASE, a shoebox-sized device for conducting human trials, D-pocket, a portable device for frequent glucose level tracking, and D-BAND, a wearable device that continuously monitors blood glucose levels. Through these advancements, DiaMonTech aims to improve the quality of life for individuals managing diabetes.

Awkward Essentials is a company based in San Jose, Costa Rica, founded in 2013. It specializes in a single product known as the dripstick, designed for post-sex cleanup. The dripstick is made from a super soft, medical-grade sponge that effectively absorbs excess fluids, allowing users to maintain personal hygiene with ease. By focusing on this innovative solution, Awkward Essentials addresses a common need for discreet and convenient after-sex cleanup, enhancing the overall experience for its users.

Vibrant Gastro is a company focused on developing and producing a chemical-free vibrating capsule designed to treat constipation. The innovative capsule aims to address the fundamental physiological aspects of constipation, promoting natural bowel activity without relying on chemical supplements or disrupting the body’s internal balance. Leveraging extensive knowledge in gastrointestinal health and motility, Vibrant Gastro offers a novel solution for individuals seeking effective relief from constipation while maintaining a commitment to chemical-free treatment options.

FitJoy is a company that specializes in designer health snacks, focusing on nutritional vegan products. Their product line includes gluten-free protein bars, grain-free pretzels, and other healthy food items, all crafted to meet the needs of health-conscious consumers. FitJoy emphasizes clean ingredients, ensuring that their snacks contain no maltitol, sucralose, artificial colors, flavors, or preservatives. In addition to promoting health, the company is committed to social responsibility through its Joy Forward initiative, which allocates a portion of proceeds from each purchase to support underprivileged children in the United States. By providing convenient and wholesome snack options, FitJoy aims to help individuals maintain their fitness with minimal effort.

Afia provides a variety bundle, a vegan bundle, traditional kibbeh, traditional falafel, za'atar falafel, garlic, and herb afia falafel. mediterranean, gluten free, vegan, plant-based, non-GMO, turmeric falafel, sun-dried tomato falafel, and three cheese falafel products.

ShotGun Seltzer LLC is a manufacturer of alcoholic spiked seltzer and cocktail products, established in 2019 and based in Austin, Texas. The company offers a range of seltzer flavors crafted from high-quality ingredients and all-natural flavors inspired by classic cocktail recipes. Its products are available in various venues, including bars, restaurants, event spaces, hotels, and resorts, providing consumers with a unique and crisp taste experience. ShotGun Seltzer aims to deliver craft quality in its offerings, appealing to customers looking for original and refreshing beverage options.

Lumen is a company that has developed a portable device and accompanying app that measures an individual's metabolism through a single breath. This technology provides users with real-time insights into their metabolic health, enabling them to receive personalized nutrition recommendations tailored to their unique metabolic data. By using Lumen, individuals can better understand their dietary needs and manage their weight effectively, whether their goals are weight loss, performance optimization, or overall wellness. The company is comprised of a diverse team of scientists, researchers, engineers, and designers dedicated to transforming how people approach their health through improved metabolic awareness.

Tushy LLC, established in 2014, is a New York-based company that manufactures and sells bidet attachments for toilets. Their products, including the Tushy Classic and Tushy Spa, offer temperature-controlled water cleansing, promoting better hygiene and environmental sustainability. Tushy's mission is to upgrade bathroom cleanliness habits in the U.S. and globally, aiming to reduce paper waste and improve sanitation. The company sells its products online, making them accessible to customers worldwide.

GoFish Cam, Inc. is a Toronto-based company founded in 2014 that specializes in the development and manufacturing of a wireless underwater action camera specifically designed for anglers. This innovative camera is designed to sit on a fishing line, allowing users to capture high-quality underwater footage of their fishing experiences. Its stabilized and waterproof design ensures that the camera records without wobbling, providing a clear view of the action. Integrated with a mobile application, the GoFish Cam enables anglers to gain insights into their fishing activities, review and edit their videos, and share content on social media, enhancing the overall fishing experience.