Waterline Ventures

Waterline Ventures, established in 2014 and based in Cambridge, Massachusetts, is a venture capital firm focused on early-stage healthcare technology and services companies. They partner with innovative entrepreneurs addressing critical issues in healthcare, such as rising costs, inconsistent quality, and access disparities, aiming to drive transformative change and improve lives globally.

Ellie Carson

Associate

John Curtin

Vice President

Robbie Greenglass

Founder and Partner

37 past transactions

SimpliFed

Seed Round in 2025
SimpliFed is a telehealth company founded in 2020 that focuses on providing virtual breastfeeding support to new and expectant parents. It addresses the challenges faced by these individuals, such as sleep deprivation and concerns about infant nutrition. SimpliFed offers a maternal care platform that delivers virtual-first care throughout the peri and postnatal periods. The company specializes in lactation and baby feeding support, as well as monitoring high-risk conditions like hypertension and gestational diabetes. By engaging with patients early, SimpliFed’s care navigators facilitate a comprehensive maternal care experience, allowing parents to receive timely answers to their questions about infant feeding through secure online and video connections.

Plenful

Series A in 2024
Plenful is a San Francisco-based company that specializes in optimizing healthcare and pharmacy operations through its AI-powered automation software. The platform focuses on automating repetitive and manual workflows, enhancing efficiency and data accuracy in administrative healthcare operations. By leveraging intelligent workflow automation and machine learning, Plenful aims to alleviate the burden on healthcare staff, resulting in significant savings in time and costs. The company's solutions contribute to improved financial and operational outcomes, ultimately fostering more efficient patient care. Plenful is supported by prominent investors in the healthcare and software sectors.

DoctorNow

Seed Round in 2024
DoctorNow builds system that is as simple to use as a word processor with complexity handled by their assistive artificial intelligence technology. Their single-minded obsession is to reduce time spent while maintaining data integrity and development to document the medical records as possible for informatics.

Ventricle Health

Seed Round in 2023
Ventricle Health specializes in remote cardiac care, offering evidence-based therapies, patient monitoring, education, and advocacy services. Its platform connects patients with a network of cardiologists, health coaches, and pharmacists, providing value-based care for chronic cardiac conditions and enabling early disease detection.

Plenful

Seed Round in 2023
Plenful is a San Francisco-based company that specializes in optimizing healthcare and pharmacy operations through its AI-powered automation software. The platform focuses on automating repetitive and manual workflows, enhancing efficiency and data accuracy in administrative healthcare operations. By leveraging intelligent workflow automation and machine learning, Plenful aims to alleviate the burden on healthcare staff, resulting in significant savings in time and costs. The company's solutions contribute to improved financial and operational outcomes, ultimately fostering more efficient patient care. Plenful is supported by prominent investors in the healthcare and software sectors.

evolvedMD

Series A in 2023
evolvedMD is a company that focuses on the integration of behavioral health services within primary care settings. By embedding behavioral health specialists onsite at medical practices, evolvedMD facilitates immediate collaborative care, which enhances the overall patient experience. The company emphasizes whole patient care, providing both upfront and ongoing support to ensure comprehensive treatment. This innovative approach not only promotes better behavioral health outcomes for patients but also represents an economically viable solution for healthcare providers seeking to improve their service offerings.

Andgo

Series A in 2022
Andgo Systems is a developer of workflow automation software focused on enhancing scheduling efficiency for organizations with high-volume scheduling needs. The company specializes in filling unplanned vacant shifts through automated and configurable workflows that streamline complex scheduling processes. By collaborating closely with clients, Andgo Systems tailors its solutions to align with existing organizational processes and integrates seamlessly with current scheduling systems. Their technology facilitates effective communication regarding immediate and planned absences, ensuring that the appropriate personnel are assigned to the right shifts, ultimately improving productivity and operational effectiveness.

SimpliFed

Seed Round in 2022
SimpliFed is a telehealth company founded in 2020 that focuses on providing virtual breastfeeding support to new and expectant parents. It addresses the challenges faced by these individuals, such as sleep deprivation and concerns about infant nutrition. SimpliFed offers a maternal care platform that delivers virtual-first care throughout the peri and postnatal periods. The company specializes in lactation and baby feeding support, as well as monitoring high-risk conditions like hypertension and gestational diabetes. By engaging with patients early, SimpliFed’s care navigators facilitate a comprehensive maternal care experience, allowing parents to receive timely answers to their questions about infant feeding through secure online and video connections.

evolvedMD

Series A in 2022
evolvedMD is a company that focuses on the integration of behavioral health services within primary care settings. By embedding behavioral health specialists onsite at medical practices, evolvedMD facilitates immediate collaborative care, which enhances the overall patient experience. The company emphasizes whole patient care, providing both upfront and ongoing support to ensure comprehensive treatment. This innovative approach not only promotes better behavioral health outcomes for patients but also represents an economically viable solution for healthcare providers seeking to improve their service offerings.

Nice Healthcare

Series A in 2022
Nice Healthcare LLC is a nurse practitioner-led primary care clinic based in Minneapolis, Minnesota, founded in 2017. The company focuses on providing comprehensive healthcare solutions for small and medium-sized businesses through innovative technology and in-home care. Its services include virtual and in-home primary care, virtual mental health therapy, and virtual physical therapy. Patients can access these services via a subscription model, allowing them to schedule video or in-person visits with licensed and certified nurse practitioners or physician assistants. This approach enables individuals to receive seamless and convenient healthcare tailored to their needs.

Koneksa

Series C in 2022
Koneksa Health Inc. is a healthcare data analytics company that specializes in designing and developing software solutions for pharmaceutical and biotech firms. The company’s flagship product, Koneksa Compare, facilitates the collection, monitoring, and analysis of patient-generated data to support clinical studies and regulatory claims. By integrating emerging technologies such as bio-sensors, activity trackers, and mobile-based questionnaires, Koneksa enhances the accuracy and breadth of data that researchers can analyze, thereby minimizing subjective biases in clinical endpoints. Additionally, the platform provides a dashboard that offers electronic clinical outcome assessments and reminders for study participants. Established in 2013 and headquartered in New York, Koneksa also maintains a presence in London, United Kingdom, and is recognized for its contributions to improving the efficiency of drug development through innovative data analysis.

Cured

Series A in 2021
Cured, Inc. is a healthcare technology company that specializes in digital marketing and customer relationship management solutions for the healthcare sector. Founded in 2018 and headquartered in San Francisco, California, with additional offices in Chicago and Denver, Cured develops a cloud-based platform that integrates various tools to enhance patient engagement and streamline operations for healthcare organizations. The company's offerings include network management, patient marketing, and insights, aimed at improving customer experiences and healthcare outcomes. By creating custom content and utilizing pre-built templates, Cured enables healthcare providers to foster better interactions with patients and unify processes and technology to enhance efficiencies and care quality.

Carta Healthcare

Series A in 2021
Carta Healthcare, Inc. is a technology company that specializes in developing a software-as-a-service platform aimed at improving hospital patient management. Founded in 2016 and headquartered in San Mateo, California, the company leverages data from existing IT systems to map the patient journey through hospitals. Its platform utilizes machine learning to identify similarities between current patients and past patients, allowing healthcare providers to personalize care based on individual needs. Additionally, it predicts potential bottlenecks, such as recovery bed shortages and cancellations, offering alerts that help hospitals optimize their operations. By combining artificial intelligence with human expertise, Carta Healthcare enhances the efficiency and quality of healthcare data management, ultimately aiming to provide a better experience for patients.

Manifold

Seed Round in 2020
Manifold, Inc. is a technology company based in Oakland, California, with additional offices in San Francisco and Boston. Founded in 2016, it specializes in developing AI-powered software programs and services primarily for the healthcare and financial sectors. The company offers a clinical research platform designed to streamline the manual workflows involved in study and data management. By providing researchers with a centralized solution for collecting, harmonizing, and analyzing life sciences data, Manifold enables them to conduct high-impact research more efficiently, reducing the time and resources typically required for complex data integrations and infrastructure setup. This innovative approach allows renowned research organizations to unlock valuable insights while minimizing costs.

Koneksa

Series B in 2020
Koneksa Health Inc. is a healthcare data analytics company that specializes in designing and developing software solutions for pharmaceutical and biotech firms. The company’s flagship product, Koneksa Compare, facilitates the collection, monitoring, and analysis of patient-generated data to support clinical studies and regulatory claims. By integrating emerging technologies such as bio-sensors, activity trackers, and mobile-based questionnaires, Koneksa enhances the accuracy and breadth of data that researchers can analyze, thereby minimizing subjective biases in clinical endpoints. Additionally, the platform provides a dashboard that offers electronic clinical outcome assessments and reminders for study participants. Established in 2013 and headquartered in New York, Koneksa also maintains a presence in London, United Kingdom, and is recognized for its contributions to improving the efficiency of drug development through innovative data analysis.

Nice Healthcare

Seed Round in 2020
Nice Healthcare LLC is a nurse practitioner-led primary care clinic based in Minneapolis, Minnesota, founded in 2017. The company focuses on providing comprehensive healthcare solutions for small and medium-sized businesses through innovative technology and in-home care. Its services include virtual and in-home primary care, virtual mental health therapy, and virtual physical therapy. Patients can access these services via a subscription model, allowing them to schedule video or in-person visits with licensed and certified nurse practitioners or physician assistants. This approach enables individuals to receive seamless and convenient healthcare tailored to their needs.

TimeDoc Health

Series A in 2020
TimeDoc Health, Inc. is a healthcare technology company based in Chicago, Illinois, with an additional office in New York. Established in 2015, the company specializes in digital care management solutions tailored for healthcare organizations. Its primary offering, the TimeDoc CCM Platform, is a virtual care management system that allows providers to manage chronic care populations effectively. The platform facilitates documentation and tracking of time spent on chronic care management services, manages task lists and workflows, maintains an audit trail, and helps identify and stratify patients eligible for chronic care management. Additionally, TimeDoc Health provides chronic care management services and care managers to support healthcare organizations in enhancing their staff capabilities. By leveraging existing electronic medical record data, TimeDoc’s solutions enable providers to monitor non-face-to-face patient care, presenting opportunities for new revenue streams while maintaining existing workflows.

RubiconMD

Series C in 2020
RubiconMD, Inc. is a healthcare technology company that offers an online platform facilitating communication between primary care clinicians and specialists through eConsults. Founded in 2013 and headquartered in New York, RubiconMD enables primary care providers to quickly seek guidance and opinions on medical cases, thereby enhancing patient care and reducing costs. The platform allows clinicians to identify specialists based on various criteria, such as ratings and experience, ensuring informed decision-making in patient management. Additionally, RubiconMD provides continuing medical education (CME) programs, including live and on-demand webinars, and features RubiconRx, a clinical pharmacy service that supports medication management for patients. The company serves a diverse clientele, including employers, community health centers, health plans, and direct primary care practices, and also offers services related to electronic health records, workflow integration, and clinician engagement.

Anagram

Series A in 2020
Anagram Inc., founded in 2014 and based in Santa Monica, California, develops a software platform designed to assist healthcare professionals, particularly eye care providers, in managing the complexities of health insurance networks. The company's platform automates vision insurance billing and facilitates instant rebates, allowing providers to offer immediate reimbursements to patients. This enables eye care providers to serve patients without the constraints of managed vision plans, leveraging partnerships with leading eyewear labs and frame manufacturers. Anagram was formerly known as Glass Health, Inc., changing its name in February 2020.

Legacy

Seed Round in 2020
Legacy is a company focused on transforming male fertility through innovative testing and preservation solutions. Founded by healthcare and fertility experts, Legacy provides home-based kits that allow men to analyze, improve, and preserve their sperm without the need to visit a clinic. Their offerings include sperm analysis and cryogenic storage options, facilitating the preservation of fertility for clients in a straightforward and accessible manner. The company collaborates with leading hospitals, fertility clinics, and progressive employers to ensure high-quality services. Legacy has garnered recognition through various awards, including victories at TechCrunch Disrupt and MassChallenge Boston, and has attracted investment from notable firms such as Bain Capital Ventures and Section 32.

Cured

Seed Round in 2019
Cured, Inc. is a healthcare technology company that specializes in digital marketing and customer relationship management solutions for the healthcare sector. Founded in 2018 and headquartered in San Francisco, California, with additional offices in Chicago and Denver, Cured develops a cloud-based platform that integrates various tools to enhance patient engagement and streamline operations for healthcare organizations. The company's offerings include network management, patient marketing, and insights, aimed at improving customer experiences and healthcare outcomes. By creating custom content and utilizing pre-built templates, Cured enables healthcare providers to foster better interactions with patients and unify processes and technology to enhance efficiencies and care quality.

Anagram

Funding Round in 2018
Anagram Inc., founded in 2014 and based in Santa Monica, California, develops a software platform designed to assist healthcare professionals, particularly eye care providers, in managing the complexities of health insurance networks. The company's platform automates vision insurance billing and facilitates instant rebates, allowing providers to offer immediate reimbursements to patients. This enables eye care providers to serve patients without the constraints of managed vision plans, leveraging partnerships with leading eyewear labs and frame manufacturers. Anagram was formerly known as Glass Health, Inc., changing its name in February 2020.

Zipnosis

Series B in 2018
Zipnosis, Inc. operates a virtual healthcare platform that facilitates connections between patients and clinicians through phone and video interviews. Founded in 2008 and based in Minneapolis, Minnesota, the company specializes in online diagnosis, triage, and telehealth services. Its innovative platform is designed to enhance patient access to care while maximizing clinician efficiency and ensuring appropriate patient outcomes. Additionally, Zipnosis offers a ZipTicket, a healthcare boarding pass that allows patients to access clinics for in-person assessments or lab tests. By providing device-agnostic virtual care, Zipnosis aims to improve the overall healthcare experience for patients and health organizations alike.

RubiconMD

Series B in 2018
RubiconMD, Inc. is a healthcare technology company that offers an online platform facilitating communication between primary care clinicians and specialists through eConsults. Founded in 2013 and headquartered in New York, RubiconMD enables primary care providers to quickly seek guidance and opinions on medical cases, thereby enhancing patient care and reducing costs. The platform allows clinicians to identify specialists based on various criteria, such as ratings and experience, ensuring informed decision-making in patient management. Additionally, RubiconMD provides continuing medical education (CME) programs, including live and on-demand webinars, and features RubiconRx, a clinical pharmacy service that supports medication management for patients. The company serves a diverse clientele, including employers, community health centers, health plans, and direct primary care practices, and also offers services related to electronic health records, workflow integration, and clinician engagement.

Common Sensing

Series A in 2018
Common Sensing, Inc. is a Cambridge, Massachusetts-based company that develops and manufactures innovative hardware and software solutions for individuals using injectable medications, particularly in diabetes care. The company is known for its flagship product, Gocap, a smart cap designed to transform conventional injector pens into connected devices that log insulin usage and provide valuable insights. The Gocap not only tracks dosing but also monitors temperature, sends reminders, and offers alerts, enhancing user engagement and medication adherence. Additionally, the accompanying Gocap app enables users to log glucose levels and meal entries, fostering better communication with healthcare providers and supporting informed decision-making. Founded in 2012, Common Sensing aims to improve health outcomes while reducing healthcare costs by facilitating education and communication for patients and their clinicians.

Health iPASS

Series A in 2017
HealthiPASS is a company focused on enhancing the patient revenue cycle by streamlining the payment process in healthcare settings. Its innovative software solution simplifies patient check-in and facilitates the collection of payments, including co-pays and prior balances, at the time of service. The platform is compatible with over 850 payers and 90 practice management systems, making it adaptable and efficient for various healthcare providers. By promoting price transparency and automating payment processes, HealthiPASS has helped many providers achieve high patient net collection rates, reduce payment denials significantly, and lower operational costs. This patient-centric approach not only improves the overall patient experience but also builds trust between patients and healthcare providers.

Carta Healthcare

Seed Round in 2017
Carta Healthcare, Inc. is a technology company that specializes in developing a software-as-a-service platform aimed at improving hospital patient management. Founded in 2016 and headquartered in San Mateo, California, the company leverages data from existing IT systems to map the patient journey through hospitals. Its platform utilizes machine learning to identify similarities between current patients and past patients, allowing healthcare providers to personalize care based on individual needs. Additionally, it predicts potential bottlenecks, such as recovery bed shortages and cancellations, offering alerts that help hospitals optimize their operations. By combining artificial intelligence with human expertise, Carta Healthcare enhances the efficiency and quality of healthcare data management, ultimately aiming to provide a better experience for patients.

Ambient Clinical Analytics

Series A in 2017
Ambient Clinical Analytics, Inc. is a healthcare technology company specializing in data assimilation, communication, and analytics for clinical decision support. Based in Rochester, Minnesota, the company develops tools tailored for use in intensive care units, operating rooms, and emergency departments. Its flagship product, AWARE, integrates with various electronic health record systems and bedside monitors to deliver critical patient information on a unified dashboard. Additionally, Ambient offers the Mayo Clinic YES Board, a multi-patient management tool that enhances situational awareness and streamlines patient flow. The company also provides specialized solutions such as Sepsis DART for real-time sepsis detection and the Ventilator-Induced Lung Injury Sniffer for monitoring ventilator patients. Furthermore, the Synthesis Platform serves as an integration hub for AWARE and the Mayo Clinic tools, facilitating seamless data exchange. Ambient Clinical Analytics was founded in 2013 and focuses on improving patient outcomes while reducing healthcare costs through innovative technology.

Madaket

Venture Round in 2017
Madaket, Inc. is a Cambridge, Massachusetts-based company that specializes in developing SaaS solutions for the healthcare industry. The company focuses on automating the healthcare enrollment process, facilitating connections between healthcare providers and payers to streamline administrative tasks. With a robust platform designed to manage provider data, Madaket enables healthcare organizations to save time and reduce manual errors while effectively tracking enrollment statuses. The company has established exclusive partnerships with notable entities such as TriZetto Provider Solutions and HealthStream, allowing it to support over 300,000 providers and an additional 325,000 providers under contract. Founded in 2012 by Mads Kvalsvik, Scott Soderstrom, Jim Dougherty, Benedict Dsilva, and Ted Achtem, Madaket aims to enhance efficiency in healthcare administration.

Hale Health

Venture Round in 2017
Hale Health Inc. is a San Francisco-based company that operates a remote care platform designed to enhance the connection between clinical teams and patients outside of traditional office settings. Founded in 2013, the platform allows patients to access their case histories, review treatment plans, and engage with health education materials. It also facilitates communication through live video visits, secure messaging, and the sharing of various media, including photos and questionnaires. By enabling healthcare providers to expand their reach beyond the clinic, Hale Health aims to improve patient access and satisfaction while increasing operational efficiency for health systems. The application is compatible with iOS devices, ensuring a user-friendly experience for both patients and providers.

RubiconMD

Series A in 2016
RubiconMD, Inc. is a healthcare technology company that offers an online platform facilitating communication between primary care clinicians and specialists through eConsults. Founded in 2013 and headquartered in New York, RubiconMD enables primary care providers to quickly seek guidance and opinions on medical cases, thereby enhancing patient care and reducing costs. The platform allows clinicians to identify specialists based on various criteria, such as ratings and experience, ensuring informed decision-making in patient management. Additionally, RubiconMD provides continuing medical education (CME) programs, including live and on-demand webinars, and features RubiconRx, a clinical pharmacy service that supports medication management for patients. The company serves a diverse clientele, including employers, community health centers, health plans, and direct primary care practices, and also offers services related to electronic health records, workflow integration, and clinician engagement.

NeueHealth

Series A in 2016
NeueHealth Inc is a healthcare company dedicated to providing high-quality, coordinated care to all health consumers, particularly those in aging and underserved populations. The company focuses on making healthcare accessible and affordable through strategic partnerships with providers and payors, aligning their interests to enhance the overall healthcare experience. By leveraging technology and data analytics, NeueHealth offers a suite of services that empower independent providers and medical groups to succeed in performance-based arrangements. This approach not only optimizes clinical outcomes but also aims to drive down costs and reduce systemic waste, ultimately delivering a more personalized and efficient healthcare experience for its members across various insurance markets, including the ACA Marketplace, Medicare, and Medicaid.

Zipnosis

Series A in 2016
Zipnosis, Inc. operates a virtual healthcare platform that facilitates connections between patients and clinicians through phone and video interviews. Founded in 2008 and based in Minneapolis, Minnesota, the company specializes in online diagnosis, triage, and telehealth services. Its innovative platform is designed to enhance patient access to care while maximizing clinician efficiency and ensuring appropriate patient outcomes. Additionally, Zipnosis offers a ZipTicket, a healthcare boarding pass that allows patients to access clinics for in-person assessments or lab tests. By providing device-agnostic virtual care, Zipnosis aims to improve the overall healthcare experience for patients and health organizations alike.

Amwell

Venture Round in 2015
Amwell is a telehealth platform based in the United States that facilitates the digital delivery of healthcare services. Founded in 2006 and headquartered in Boston, the company connects providers, insurers, patients, and innovators to enhance access to affordable, high-quality care. Amwell offers a comprehensive platform designed to address a wide range of telehealth needs, including urgent, acute, and post-acute care, as well as chronic care management and healthy living. With extensive experience in the field, Amwell supports over 240 health systems, which encompass 2,000 hospitals, and collaborates with 55 health plan partners, reaching more than 150 million individuals through over 36,000 employers. The platform provides both on-demand and scheduled consultations, enabling diverse care models that range from primary and urgent care to specialized services such as telestroke and telepsychiatry.

1DocWay

Seed Round in 2015
1DocWay, Inc. is a telemedicine company that specializes in building telepsychiatry networks for various healthcare facilities, including psychiatric hospitals, clinics, and emergency departments. Founded in 2011 and based in New York, the company offers a browser-based platform that enables secure videoconferencing, appointment scheduling, and medical records management. This platform connects patients with local psychiatric hospitals, psychiatrists, and advanced practice registered nurses who can provide care remotely. 1DocWay serves a diverse range of clients across multiple states, including Arkansas, California, Texas, and North Carolina. The company's innovative approach facilitates access to mental health services, particularly for rural, elderly, disabled, and busy patients, enhancing scheduling flexibility and improving the overall healthcare experience.

RubiconMD

Seed Round in 2014
RubiconMD, Inc. is a healthcare technology company that offers an online platform facilitating communication between primary care clinicians and specialists through eConsults. Founded in 2013 and headquartered in New York, RubiconMD enables primary care providers to quickly seek guidance and opinions on medical cases, thereby enhancing patient care and reducing costs. The platform allows clinicians to identify specialists based on various criteria, such as ratings and experience, ensuring informed decision-making in patient management. Additionally, RubiconMD provides continuing medical education (CME) programs, including live and on-demand webinars, and features RubiconRx, a clinical pharmacy service that supports medication management for patients. The company serves a diverse clientele, including employers, community health centers, health plans, and direct primary care practices, and also offers services related to electronic health records, workflow integration, and clinician engagement.

Wellframe

Series A in 2014
Wellframe Inc. is a Boston-based company that specializes in digital care management and health advocacy solutions. Founded in 2011, it partners with health plans across the country to enhance the relationship between healthcare providers and members. Wellframe's offerings include a mobile application that facilitates daily health reporting, a care team dashboard to prioritize patient needs, and an array of communication tools for two-way messaging. The company also provides comprehensive operational services, such as implementation support, recruiting, and analytics. Additionally, Wellframe's platform employs real-time data and artificial intelligence to deliver personalized care protocols, enabling caregivers to monitor patient status effectively and identify when intervention is necessary. By focusing on mobile patient engagement and care management, Wellframe aims to improve health outcomes and empower individuals in managing their health.
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