Waterline Ventures

Waterline Ventures, founded in 2014 and based in Cambridge, Massachusetts, is a venture capital firm focused on early-stage investments in healthcare technology and services. The firm partners with innovative entrepreneurs who are addressing significant challenges in the healthcare industry, such as rising costs, inconsistent quality, and limited access to care. By supporting companies that aim to transform healthcare delivery, Waterline Ventures seeks to foster technological advancements that can enhance patient outcomes and overall healthcare efficiency. The firm recognizes the substantial and growing opportunity for innovation in this sector and is committed to backing entrepreneurs who are leading this change.

Ellie Carson

Associate

John Curtin

Vice President

Robbie Greenglass

Founder and Partner

37 past transactions

SimpliFed

Seed Round in 2025
SimpliFed is a telehealth company founded in 2020 that offers virtual breastfeeding support to new and pregnant parents. The company focuses on providing accessible care during the peri and postnatal periods, addressing the challenges faced by parents, including sleep deprivation and concerns about infant nutrition. SimpliFed specializes in lactation and baby feeding support, as well as monitoring high-risk conditions such as hypertension and gestational diabetes. Through secure online and video-based connections, patients can engage with care navigators who guide them through their maternal care journey, helping them obtain quick answers to their questions about their infants' dietary needs.

Plenful

Series A in 2024
Plenful is a San Francisco-based company that specializes in healthcare and pharmacy operations through the use of AI-powered automation software. The platform is designed to streamline repetitive and manual workflows, enhancing efficiency and data accuracy in administrative tasks. By utilizing intelligent workflow automation and machine learning, Plenful aims to alleviate the burden on healthcare staff, ultimately leading to improved financial and operational outcomes while promoting more effective patient care. The company's innovative approach is supported by prominent investors in the healthcare and software sectors, reflecting its commitment to transforming the operational landscape of healthcare providers.

DoctorNow

Seed Round in 2024
DoctorNow builds system that is as simple to use as a word processor with complexity handled by their assistive artificial intelligence technology. Their single-minded obsession is to reduce time spent while maintaining data integrity and development to document the medical records as possible for informatics.

Ventricle Health

Seed Round in 2023
Ventricle Health offers evidence-based therapy, remote patient monitoring, patient education, and advocacy services for cardiac care.

Plenful

Seed Round in 2023
Plenful is a San Francisco-based company that specializes in healthcare and pharmacy operations through the use of AI-powered automation software. The platform is designed to streamline repetitive and manual workflows, enhancing efficiency and data accuracy in administrative tasks. By utilizing intelligent workflow automation and machine learning, Plenful aims to alleviate the burden on healthcare staff, ultimately leading to improved financial and operational outcomes while promoting more effective patient care. The company's innovative approach is supported by prominent investors in the healthcare and software sectors, reflecting its commitment to transforming the operational landscape of healthcare providers.

evolvedMD

Series A in 2023
evolvedMD focuses on integrating behavioral health services into primary care settings by embedding specialists directly within healthcare practices. This approach facilitates immediate collaborative care, allowing for a seamless patient experience. The company aims to provide comprehensive and ongoing support for patients, which enhances the overall quality of care and promotes better behavioral health outcomes. By adopting this innovative model, evolvedMD offers a practical solution for healthcare providers seeking to address the behavioral health needs of their patients effectively.

Andgo

Series A in 2022
Andgo Systems is a company that offers a shift fill automation tool to streamline scheduling practices in high-volume environments. Their software is designed to assist organizations in efficiently filling unplanned vacant shifts, addressing both immediate needs and planned absences. By providing automated and configurable workflows, Andgo simplifies complex scheduling processes and enhances communication regarding staffing needs. The company collaborates with organizations to tailor workflows that align with existing scheduling systems and processes, ensuring that the right personnel are assigned to the appropriate shifts. This approach ultimately aims to improve productivity and operational efficiency within organizations.

SimpliFed

Seed Round in 2022
SimpliFed is a telehealth company founded in 2020 that offers virtual breastfeeding support to new and pregnant parents. The company focuses on providing accessible care during the peri and postnatal periods, addressing the challenges faced by parents, including sleep deprivation and concerns about infant nutrition. SimpliFed specializes in lactation and baby feeding support, as well as monitoring high-risk conditions such as hypertension and gestational diabetes. Through secure online and video-based connections, patients can engage with care navigators who guide them through their maternal care journey, helping them obtain quick answers to their questions about their infants' dietary needs.

evolvedMD

Series A in 2022
evolvedMD focuses on integrating behavioral health services into primary care settings by embedding specialists directly within healthcare practices. This approach facilitates immediate collaborative care, allowing for a seamless patient experience. The company aims to provide comprehensive and ongoing support for patients, which enhances the overall quality of care and promotes better behavioral health outcomes. By adopting this innovative model, evolvedMD offers a practical solution for healthcare providers seeking to address the behavioral health needs of their patients effectively.

Nice Healthcare

Series A in 2022
Nice Healthcare LLC is a nurse practitioner-led primary care clinic based in Minneapolis, Minnesota, founded in 2017. The company provides comprehensive healthcare services primarily to small and medium-sized businesses, utilizing technology to facilitate both in-home and virtual care. Its offerings include virtual primary care, mental health therapy, and physical therapy. Patients can access these services through subscription-based plans, allowing them to schedule appointments for video visits or in-home consultations with licensed and certified nurse practitioners or physician assistants. This model aims to enhance accessibility and convenience in healthcare delivery.

Koneksa

Series C in 2022
Koneksa Health Inc. is a healthcare data analytics company focused on enhancing clinical studies and disease research through the use of remotely generated patient data. The company's software, Koneksa Compare, facilitates the collection, visualization, and analysis of patient-generated data, incorporating emerging technologies such as bio-sensors, activity trackers, and mobile-based questionnaires. This platform allows pharmaceutical and biotech companies, as well as academic researchers, to make informed decisions and regulatory claims based on objective data. Koneksa also provides biometric devices that generate electronic clinical outcome assessments and offers a dashboard for monitoring patient engagement, which includes reminders for study subjects. Founded in 2013 and headquartered in New York, Koneksa has an additional office in London, United Kingdom.

Cured

Series A in 2021
Cured, Inc. is a healthcare technology company that specializes in developing digital marketing tools and customer relationship management platforms for the healthcare sector. Founded in 2018 and headquartered in San Francisco, with additional offices in Chicago and Denver, Cured offers solutions that connect health systems and organizations to patients and their families. The company's cloud-based platform focuses on network management, patient marketing, and customer experience, providing design and product development services that address the unique challenges faced by healthcare and life sciences organizations. By leveraging modern business tools and integrating contact centers with electronic medical records, Cured enables clients to enhance brand awareness, improve patient satisfaction, and create engaging digital experiences that foster better healthcare behaviors and outcomes.

Carta Healthcare

Series A in 2021
Carta Healthcare, Inc. is a technology company that specializes in developing a software-as-a-service platform aimed at improving hospital patient management. Founded in 2016 and headquartered in San Mateo, California, the company leverages data from existing IT systems to map the patient journey through hospitals. Its platform utilizes machine learning to identify similarities between current patients and past patients, allowing healthcare providers to personalize care based on individual needs. Additionally, it predicts potential bottlenecks, such as recovery bed shortages and cancellations, offering alerts that help hospitals optimize their operations. By combining artificial intelligence with human expertise, Carta Healthcare enhances the efficiency and quality of healthcare data management, ultimately aiming to provide a better experience for patients.

Manifold

Seed Round in 2020
Manifold, Inc. is a technology company based in Oakland, California, with additional offices in San Francisco and Boston. Founded in 2016, it specializes in AI software programs and services tailored for the healthcare and financial sectors. The company has developed an AI-powered clinical research platform that aims to simplify the manual workflows associated with study and data management. By providing researchers with a centralized solution for collecting, harmonizing, and analyzing life sciences data, Manifold enables high-impact research and collaborations while reducing resource requirements. This innovative approach allows research organizations to conduct studies much faster and at lower costs, unlocking new insights in the process.

Koneksa

Series B in 2020
Koneksa Health Inc. is a healthcare data analytics company focused on enhancing clinical studies and disease research through the use of remotely generated patient data. The company's software, Koneksa Compare, facilitates the collection, visualization, and analysis of patient-generated data, incorporating emerging technologies such as bio-sensors, activity trackers, and mobile-based questionnaires. This platform allows pharmaceutical and biotech companies, as well as academic researchers, to make informed decisions and regulatory claims based on objective data. Koneksa also provides biometric devices that generate electronic clinical outcome assessments and offers a dashboard for monitoring patient engagement, which includes reminders for study subjects. Founded in 2013 and headquartered in New York, Koneksa has an additional office in London, United Kingdom.

Nice Healthcare

Seed Round in 2020
Nice Healthcare LLC is a nurse practitioner-led primary care clinic based in Minneapolis, Minnesota, founded in 2017. The company provides comprehensive healthcare services primarily to small and medium-sized businesses, utilizing technology to facilitate both in-home and virtual care. Its offerings include virtual primary care, mental health therapy, and physical therapy. Patients can access these services through subscription-based plans, allowing them to schedule appointments for video visits or in-home consultations with licensed and certified nurse practitioners or physician assistants. This model aims to enhance accessibility and convenience in healthcare delivery.

TimeDoc Health

Series A in 2020
TimeDoc Health, based in Chicago, develops digital care management solutions aimed at healthcare organizations. Its primary offering, the TimeDoc CCM Platform, is a virtual care management tool that assists providers in managing chronic care populations. The platform allows healthcare facilities to document and track time spent on chronic care management services, manage workflows, maintain an audit trail, and identify eligible patients for chronic care management. Additionally, TimeDoc Health offers chronic care management services and provides care managers to healthcare organizations to enhance their staffing capabilities. The company was incorporated in 2015 and also has an office in New York.

RubiconMD

Series C in 2020
RubiconMD, Inc. operates an online platform that facilitates communication between primary care clinicians and specialists through its eConsult service. This platform allows primary care providers to seek expert guidance on medical cases, thereby enhancing patient care and reducing healthcare costs. In addition to the eConsult service, RubiconMD offers a continuing medical education (CME) program for eConsult submissions, live and on-demand webinars, and RubiconRx, a clinical pharmacy platform that supports patient medication access. The company also provides support in electronic health records, workflow integration, onboarding, and clinician engagement. Founded in 2013 and headquartered in New York, RubiconMD serves a diverse clientele, including employers, community health centers, correctional health facilities, health plans, and direct primary care practices.

Anagram

Series A in 2020
Anagram Inc. is a software company based in Santa Monica, California, that develops a platform to support healthcare professionals, particularly in the eye care sector, with the complexities of health insurance networks. Established in 2014 and previously known as Glass Health, Inc., Anagram offers an online insurance assistant designed to help manage patients' healthcare plans by highlighting out-of-network benefits and simplifying claim submissions. The platform enables eye care providers to navigate insurance benefits effectively, facilitating seamless billing and instant rebates through collaborations with eyewear labs and frame manufacturers. This approach allows providers to deliver services without the limitations imposed by managed vision plans, enhancing the overall patient experience.

Legacy

Seed Round in 2020
Legacy is a company focused on transforming male fertility through innovative testing and preservation solutions. Founded by healthcare and fertility experts, Legacy provides home-based kits that allow men to analyze, improve, and preserve their sperm without the need to visit a clinic. Their offerings include sperm analysis and cryogenic storage options, facilitating the preservation of fertility for clients in a straightforward and accessible manner. The company collaborates with leading hospitals, fertility clinics, and progressive employers to ensure high-quality services. Legacy has garnered recognition through various awards, including victories at TechCrunch Disrupt and MassChallenge Boston, and has attracted investment from notable firms such as Bain Capital Ventures and Section 32.

Cured

Seed Round in 2019
Cured, Inc. is a healthcare technology company that specializes in developing digital marketing tools and customer relationship management platforms for the healthcare sector. Founded in 2018 and headquartered in San Francisco, with additional offices in Chicago and Denver, Cured offers solutions that connect health systems and organizations to patients and their families. The company's cloud-based platform focuses on network management, patient marketing, and customer experience, providing design and product development services that address the unique challenges faced by healthcare and life sciences organizations. By leveraging modern business tools and integrating contact centers with electronic medical records, Cured enables clients to enhance brand awareness, improve patient satisfaction, and create engaging digital experiences that foster better healthcare behaviors and outcomes.

Anagram

Funding Round in 2018
Anagram Inc. is a software company based in Santa Monica, California, that develops a platform to support healthcare professionals, particularly in the eye care sector, with the complexities of health insurance networks. Established in 2014 and previously known as Glass Health, Inc., Anagram offers an online insurance assistant designed to help manage patients' healthcare plans by highlighting out-of-network benefits and simplifying claim submissions. The platform enables eye care providers to navigate insurance benefits effectively, facilitating seamless billing and instant rebates through collaborations with eyewear labs and frame manufacturers. This approach allows providers to deliver services without the limitations imposed by managed vision plans, enhancing the overall patient experience.

Zipnosis

Series B in 2018
Zipnosis, Inc. is a healthcare company based in Minneapolis, Minnesota, that specializes in virtual care solutions. Founded in 2008, the company operates a platform that connects patients with clinicians through phone and video interviews, facilitating online diagnosis and triage. Zipnosis offers a unique service called ZipTicket, which acts as a healthcare boarding pass, allowing patients to access clinics for in-person assessments or lab tests when necessary. The platform is designed to enhance patient choice and convenience while improving efficiency for healthcare providers. Through its innovative approach, Zipnosis aims to expand access to immediate care and improve clinical outcomes for health organizations.

RubiconMD

Series B in 2018
RubiconMD, Inc. operates an online platform that facilitates communication between primary care clinicians and specialists through its eConsult service. This platform allows primary care providers to seek expert guidance on medical cases, thereby enhancing patient care and reducing healthcare costs. In addition to the eConsult service, RubiconMD offers a continuing medical education (CME) program for eConsult submissions, live and on-demand webinars, and RubiconRx, a clinical pharmacy platform that supports patient medication access. The company also provides support in electronic health records, workflow integration, onboarding, and clinician engagement. Founded in 2013 and headquartered in New York, RubiconMD serves a diverse clientele, including employers, community health centers, correctional health facilities, health plans, and direct primary care practices.

Common Sensing

Series A in 2018
Common Sensing, Inc. is a Cambridge, Massachusetts-based company that specializes in developing data-driven hardware and software solutions for individuals using injectable medications, particularly in diabetes care. Founded in 2012, the company is known for its flagship product, the Gocap, a smart cap that transforms conventional injector pens into smart injectors. This device allows for the logging of insulin doses, monitoring of temperature, and provides reminders and alerts, facilitating better management of insulin usage. Additionally, the Gocap app enhances patient care by allowing users to track the effects of insulin alongside glucose and meal entries, creating a comprehensive snapshot of their health. By enabling patients to share their insulin logs with healthcare providers and family members, Common Sensing aims to improve access to care, reduce healthcare costs, and ultimately enhance health outcomes for those managing diabetes.

Health iPASS

Series A in 2017
HealthiPASS is a company focused on enhancing the patient revenue cycle by streamlining the payment process in healthcare settings. Its innovative software solution simplifies patient check-in and facilitates the collection of payments, including co-pays and prior balances, at the time of service. The platform is compatible with over 850 payers and 90 practice management systems, making it adaptable and efficient for various healthcare providers. By promoting price transparency and automating payment processes, HealthiPASS has helped many providers achieve high patient net collection rates, reduce payment denials significantly, and lower operational costs. This patient-centric approach not only improves the overall patient experience but also builds trust between patients and healthcare providers.

Carta Healthcare

Seed Round in 2017
Carta Healthcare, Inc. is a technology company that specializes in developing a software-as-a-service platform aimed at improving hospital patient management. Founded in 2016 and headquartered in San Mateo, California, the company leverages data from existing IT systems to map the patient journey through hospitals. Its platform utilizes machine learning to identify similarities between current patients and past patients, allowing healthcare providers to personalize care based on individual needs. Additionally, it predicts potential bottlenecks, such as recovery bed shortages and cancellations, offering alerts that help hospitals optimize their operations. By combining artificial intelligence with human expertise, Carta Healthcare enhances the efficiency and quality of healthcare data management, ultimately aiming to provide a better experience for patients.

Ambient Clinical Analytics

Series A in 2017
Ambient Clinical Analytics, Inc. develops healthcare data assimilation and decision support tools aimed at enhancing patient care in intensive care units, operating rooms, and emergency departments. The company's flagship product, AWARE, integrates with various electronic health record systems and bedside monitors to deliver crucial patient information on a single-screen dashboard, facilitating real-time clinical decision-making. Additionally, Ambient offers the Mayo Clinic YES Board, which enhances patient flow by providing real-time situational awareness. The company also specializes in syndromic surveillance solutions, including Sepsis DART, which aids in the detection and confirmation of sepsis, and the Ventilator-Induced Lung Injury Sniffer, designed for ventilator monitoring. Furthermore, Ambient provides the Synthesis Platform, which serves as an integration tool for AWARE and the Mayo Clinic solutions. Founded in 2013 and headquartered in Rochester, Minnesota, Ambient Clinical Analytics focuses on reducing healthcare costs and improving patient outcomes through its innovative tools and technology.

Madaket

Venture Round in 2017
Madaket, Inc. is a provider of SaaS solutions focused on the healthcare industry, headquartered in Cambridge, Massachusetts. Founded in 2012, the company specializes in automating healthcare enrollment processes, effectively connecting healthcare providers and payers to streamline administrative tasks. Madaket's platform enhances efficiency by reducing manual errors and allowing organizations to track the status of enrollments. The company has established exclusive partnerships with TriZetto Provider Solutions and HealthStream, facilitating access to a network that includes over 300,000 providers already in its system and an additional 325,000 providers under contract.

Hale Health

Venture Round in 2017
Hale Health Inc. operates a remote care platform designed to enhance communication between clinical teams and patients outside traditional office settings. Founded in 2013 and based in San Francisco, California, the platform allows patients to access their case histories, review treatment plans, and engage with health education materials. It facilitates seamless interactions through live video visits, secure messaging, and the sharing of photos, videos, and questionnaires. By enabling providers and patients to connect effectively, Hale Health aims to increase healthcare capacity, improve access, and enhance patient satisfaction while streamlining workflows for clinical practices.

RubiconMD

Series A in 2016
RubiconMD, Inc. operates an online platform that facilitates communication between primary care clinicians and specialists through its eConsult service. This platform allows primary care providers to seek expert guidance on medical cases, thereby enhancing patient care and reducing healthcare costs. In addition to the eConsult service, RubiconMD offers a continuing medical education (CME) program for eConsult submissions, live and on-demand webinars, and RubiconRx, a clinical pharmacy platform that supports patient medication access. The company also provides support in electronic health records, workflow integration, onboarding, and clinician engagement. Founded in 2013 and headquartered in New York, RubiconMD serves a diverse clientele, including employers, community health centers, correctional health facilities, health plans, and direct primary care practices.

NeueHealth

Series A in 2016
NeueHealth Inc is a healthcare company dedicated to providing high-quality, coordinated care to all health consumers, particularly those in aging and underserved populations. The company focuses on making healthcare accessible and affordable through strategic partnerships with providers and payors, aligning their interests to enhance the overall healthcare experience. By leveraging technology and data analytics, NeueHealth offers a suite of services that empower independent providers and medical groups to succeed in performance-based arrangements. This approach not only optimizes clinical outcomes but also aims to drive down costs and reduce systemic waste, ultimately delivering a more personalized and efficient healthcare experience for its members across various insurance markets, including the ACA Marketplace, Medicare, and Medicaid.

Zipnosis

Series A in 2016
Zipnosis, Inc. is a healthcare company based in Minneapolis, Minnesota, that specializes in virtual care solutions. Founded in 2008, the company operates a platform that connects patients with clinicians through phone and video interviews, facilitating online diagnosis and triage. Zipnosis offers a unique service called ZipTicket, which acts as a healthcare boarding pass, allowing patients to access clinics for in-person assessments or lab tests when necessary. The platform is designed to enhance patient choice and convenience while improving efficiency for healthcare providers. Through its innovative approach, Zipnosis aims to expand access to immediate care and improve clinical outcomes for health organizations.

Amwell

Venture Round in 2015
Amwell is a telehealth platform based in the United States that facilitates the digital delivery of healthcare services. Founded in 2006 and headquartered in Boston, the company connects providers, insurers, patients, and innovators to enhance access to affordable, high-quality care. Amwell offers a comprehensive platform designed to address a wide range of telehealth needs, including urgent, acute, and post-acute care, as well as chronic care management and healthy living. With extensive experience in the field, Amwell supports over 240 health systems, which encompass 2,000 hospitals, and collaborates with 55 health plan partners, reaching more than 150 million individuals through over 36,000 employers. The platform provides both on-demand and scheduled consultations, enabling diverse care models that range from primary and urgent care to specialized services such as telestroke and telepsychiatry.

1DocWay

Seed Round in 2015
1DocWay, Inc. is a telemedicine company that specializes in telepsychiatry, connecting psychiatric hospitals, clinics, emergency departments, and patients through a browser-based platform. Founded in 2011 and headquartered in New York, 1DocWay offers features such as videoconferencing, appointment scheduling, and medical records management, facilitating remote consultations with local psychiatrists and advanced practice registered nurses (APRNs). The company's services are tailored to meet the needs of rural, elderly, disabled, and busy patients, allowing them to conveniently schedule online appointments and receive care via secure video chat. This model not only enhances patient access to mental health services but also offers physicians increased scheduling flexibility and revenue opportunities. 1DocWay operates in multiple states across the U.S., including Arkansas, California, and Texas, and is a subsidiary of Genoa, a company focused on enhancing healthcare quality.

RubiconMD

Seed Round in 2014
RubiconMD, Inc. operates an online platform that facilitates communication between primary care clinicians and specialists through its eConsult service. This platform allows primary care providers to seek expert guidance on medical cases, thereby enhancing patient care and reducing healthcare costs. In addition to the eConsult service, RubiconMD offers a continuing medical education (CME) program for eConsult submissions, live and on-demand webinars, and RubiconRx, a clinical pharmacy platform that supports patient medication access. The company also provides support in electronic health records, workflow integration, onboarding, and clinician engagement. Founded in 2013 and headquartered in New York, RubiconMD serves a diverse clientele, including employers, community health centers, correctional health facilities, health plans, and direct primary care practices.

Wellframe

Series A in 2014
Wellframe Inc. is a Boston-based company that specializes in digital care management solutions aimed at enhancing the relationship between health plans and their members. Founded in 2011, Wellframe develops a mobile patient engagement platform that utilizes real-time member-generated data and artificial intelligence to create personalized care protocols. Its offerings include a member mobile application for daily health tracking, a care team dashboard for prioritizing patient needs, and two-way communication solutions. The company also provides various services such as implementation, operational change management, and analytics. Additionally, Wellframe's digital health advocate solutions encompass intake assessments, concierge programs, and integrated workflows to enhance care management. The company's strategic partnerships with health plans nationwide allow it to deliver impactful health management solutions that empower patients and improve care outcomes.
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