Next Level Ventures is a Des Moines, Iowa-based venture capital firm founded in 2013 that makes early-stage and growth equity investments in technology-driven companies. The firm targets sectors including agriculture and biosciences, SaaS, artificial intelligence and machine learning, fintech, health tech, telecommunications, and other technology-enabled businesses, often taking minority stakes. Typical deal sizes range from $0.5 million to $5 million, with larger transactions possible through investment partners. The firm supports portfolio companies beyond capital through operational guidance, strategic advice, and networking to help drive growth and profitability. It seeks to partner with management teams to build value and, where appropriate, join the board of portfolio companies to provide governance and strategic oversight. Based in Des Moines, the firm emphasizes investments in Iowa and U.S.-based technology and innovative sectors.

ISA Ventures is a Cedar Rapids, Iowa-based venture capital firm and fund manager that focuses on supporting Iowa-based companies across sectors such as biotechnology, healthcare and medical technologies, education technology, engineering and automation, agriculture and food processing, insurance and finance technologies, and transportation and logistics. The firm pursues early-stage, expansion, and later-stage investments, providing capital to grow portfolio companies while prioritizing operations within Iowa.

Ag Startup Engine is a pre-seed investment group and early-stage venture firm based in Ames, Iowa, focused on fostering innovation in agriculture technology. It connects early-stage startups with investors and industry partners, providing funding, mentorship and an ecosystem to address gaps in seed-stage investment and expert guidance for ag entrepreneurs in the Midwest. The firm seeks opportunities in robotics and drones, software as a service, financial technology, precision agriculture, animal health, livestock automation, and clean technology, underscoring its Midwest focus. Led by experienced agritech professionals, Ag Startup Engine aims to support startups through funding, networking, and problem-solving to accelerate adoption of new agtech solutions.

Ames Seed Capital is a venture capital firm based in Ames, Iowa, founded in 1987. It specializes in early-stage and expansion investments in startups and targets opportunities in Ames, Story City, Nevada, Huxley and surrounding Story County communities.

Alumni Ventures is a venture capital firm that provides accredited investors access to venture-stage and late-stage private market investments. It offers funds, syndicates, investing clubs, and co-investment opportunities with established venture capital firms, and it provides venture investing education through AV Academy along with resources for startup founders.

Khosla Ventures is a California-based venture capital firm founded in 2004 that backs technology-driven startups across multiple sectors, including artificial intelligence, healthcare, sustainability, digital health, and consumer technology. The firm provides capital and strategic guidance to companies at early and growth stages, with an emphasis on disruptive technologies and world-changing businesses. It operates a range of funds, including seed and later-stage vehicles, and maintains a broad investment thesis that covers AI, climate tech, energy efficiency, and other high-potential areas, primarily focused in the United States. The firm is known for working closely with entrepreneurs to build long-lasting companies.

Prairie Crest Capital is a Des Moines, Iowa-based venture capital firm founded in 2016. It focuses on early-stage investments in agriculture technology and related innovations, targeting seed and Series A rounds across the United States. The firm leverages its financial and operating experience to provide funding and development support to promising companies poised for accelerated growth.

Founded in 2014, Twelve19 Ventures is a venture capital firm based in Des Moines, Iowa. It invests in consumer and enterprise sectors, participating in angel, seed, and venture rounds for early-stage and growth companies backed by strong, innovative entrepreneurs and management teams.

UnityPoint Health Ventures is the corporate venture capital arm of UnityPoint Health, based in West Des Moines, Iowa. Established in 2019, it makes early-stage investments in healthcare and related technology sectors, including digital therapeutics, health information technology, tech-enabled services, medical devices, and diagnostics, seeking partnerships and opportunities that advance patient care and support healthcare providers.

Founders Fund is a San Francisco-based venture capital firm that provides funding across all stages to science and technology companies pursuing transformative innovations. The firm backs startups addressing complex problems in areas such as aerospace, artificial intelligence, energy, health, cybersecurity, data analytics, and software, and has supported notable portfolio companies including SpaceX, Palantir, Facebook and Airbnb. Founders Fund emphasizes a founder-friendly approach that aims to offer substantial support with minimal interference, while potentially deploying capital globally as needed. The firm seeks to invest in companies with the potential to reshape industries and the future through advanced engineering, manufacturing, and information technology.

ManchesterStory is a West Des Moines, Iowa-based venture capital firm that backs early- to growth-stage companies in InsurTech, FinTech, and HealthTech, with a focus on applications across insurance, financial services, and healthcare. The firm collaborates with a broad network of insurance carriers, brokers, and wholesalers to support portfolio companies through development and market penetration. Since its founding, ManchesterStory has invested in a diverse set of startups aiming to strengthen the insurance value chain and related sectors, and it operates a dedicated initiative, the BrokerTech Fund, to advance technology solutions serving insurance brokers and wholesalers.

Innova is an early-stage venture capital firm focused on AgTech and FarmTech. It provides initial funding checks ranging from $250,000 to $2,000,000 to startups developing solutions that improve farming profitability. Founded in 2007, Innova backs companies in the pre-seed to Series A stages, with a thesis that prioritizes technologies that boost farmer economics across inputs, labor, on-farm data, and decision support. The firm has backed notable portfolio companies such as AgriSync (acquired by Deere & Company), SwineTech, and Growers Holdings, and has continued to invest in Lilac Agriculture and AGRITX. It is supported by prominent agriculture players, including AgCO Ventures and Farm Credit organizations, reflecting a broad network in the farming sector. Innova operates with a focus on enabling startups to scale through strategic guidance and connections to industry partners to translate innovations into practical, economically viable tools for farmers.

S2G Investments is a Chicago-based multi-stage venture capital firm focused on food, agriculture, oceans, and energy sectors. It provides capital to venture and growth-stage companies pursuing market-driven solutions to transform food systems and energy resources. The firm supports entrepreneurs and leadership teams with strategies intended to deliver increased value and better performance than conventional options. Its investment approach spans seed to growth, with a cross-sector portfolio across areas such as agriculture, ingredients, infrastructure and logistics, food safety and technology, retail and restaurants, and consumer brands. S2G manages over $2.8 billion in assets and has backed more than 120 portfolio companies.

Ulu Ventures is a Palo Alto based venture capital firm that invests in seed and early‑stage technology companies. Founded in 2008, it backs businesses across enterprise software, fintech, healthtech, sustainability, edtech, and blockchain, with additional emphasis on internet-enabled consumer and business services, digital media, mobile, and online advertising. The firm typically co-invests with other angels or venture funds, contributing roughly 500,000 to 1,000,000 per opportunity. It emphasizes diverse founding teams, including women, minority, URM, and immigrant founders, viewing diversity as a driver of performance. Ulu operates with a regional focus on the Bay Area, particularly Silicon Valley, and supports portfolio companies through strategic guidance and networks.

Hard Yaka is an investment firm based in Crystal Bay, Nevada, focusing on technology-driven sectors such as payments, digital identity, banking, and related fintech services, as well as exchange platforms and regtech. It engages in venture and private equity investments, including early-stage rounds and buyouts, often pursuing majority stakes in distressed opportunities. The firm has invested in over 250 companies and facilitated more than $3 billion in investments, supporting portfolio companies through digital transformation and universal access initiatives while emphasizing regulatory compliance.

Craft Ventures is a San Francisco–based venture capital firm, founded in 2017, that backs early-stage and growth technology companies across business-to-business software, enterprise, consumer, and cybersecurity sectors. The firm combines entrepreneurial experience with investor acumen, focusing on founder-first partnerships and providing strategic guidance, access to senior operators, and scalable playbooks to help companies build generational businesses. It operates as a registered investment adviser and emphasizes high-value, low-maintenance involvement designed by founders for founders.

Union Square Ventures is a New York-based venture capital firm founded in 2003 that focuses on early-stage to growth-stage internet companies. It concentrates on the applications layer of the web, internet services, and web services that create large networks, with emphasis on businesses that generate network effects across sectors such as social media, marketplaces, developer tools, learning, health, fintech, web3 and decentralized systems, technology, and climate. The firm typically makes initial investments around 1 million dollars and can participate in larger rounds up to about 20 million dollars, often taking a lead role and working closely with founders to support growth. It pursues investments across major markets globally, including New York, San Francisco, London, and Berlin.

Initialized Capital is a San Francisco-based early-stage venture capital firm focused on seed investments, supporting founders building innovative technology companies across sectors such as software as a service, sustainability, health, AI, and crypto with long-term mentorship and guidance from early-stage to growth stages.

Rand Capital is a regional business development company focused on privately held, lower-middle-market companies in Western and Upstate New York, particularly the Buffalo and Niagara regions. It provides capital through debt and equity investments, often taking a minority stake and seeking a seat on the board. The firm emphasizes companies with unique products, technologies, or services across healthcare, consumer products, manufacturing, software, and professional services. Typical investments range from roughly half a million to several million dollars per company, with follow-ons that may extend to around three million; initial rounds commonly total up to five million. Rand Capital aims for current income and capital appreciation, planning multi-year horizons of approximately five to seven years. The business traces back to 1969 and is based in Buffalo, New York, concentrating on opportunities within a three to five hour drive of Western New York, including nearby Canada.

RiverPark Ventures is an early-stage venture capital firm based in New York that is industry-agnostic and invests in the future of enterprise technology and the evolution of consumer behavior. It backs high-growth, disruptive businesses with proven models and favors opportunities with clear leadership and market focus. The firm provides portfolio companies with guidance and access to a broad network to support expansion, and it targets companies generating preliminary revenue. RiverPark Ventures emphasizes entrepreneur-led partnerships and pragmatic, founder-friendly collaboration to help portfolio companies scale.

Company Ventures is a New York-based early-stage venture capital firm that backs startups in healthcare, fintech, data, artificial intelligence, software-as-a-service, and enterprise software. The firm emphasizes a community-driven approach, operating a physical space that enables daily founder collaboration, mentorship, and investment opportunities. It focuses on generational AI companies at the application, data infrastructure, and model augmentation levels, and engages with ventures through hands-on support and capital both within its community and beyond. Its alumni residency program comprises 208 portfolio companies that have collectively raised over $5 billion, illustrating the firm's commitment to helping founders build and scale early-stage ventures.

Launchpad Digital Health is a U.S.-based early-stage venture capital firm focused on digital health. Based in Emeryville, California, it partners with digital health entrepreneurs at an early stage to build companies that aim to improve care, lower costs, and increase patient convenience. The firm provides significant capital, with seed investments up to about $1 million and $2-3 million in Series A and B rounds. Its founders have funded and operated numerous healthcare and technology companies over the past two decades, positioning Launchpad as a leading investor in the digital health space. The firm seeks to foster growth and disrupt traditional healthcare models by supporting technologies such as remote diagnostics and monitoring, electronic health records, data analytics and big data, healthy living and wellness, patient compliance, and independent living support.

GGV Capital is a global venture capital firm that reorganized in March 2024 into two distinct entities: Granite Asia and Notable Capital. Granite Asia, headquartered in Singapore, focuses on investments across the Asia-Pacific region, including Southeast Asia, Japan, China, India, and Australia. Notable Capital, based in Silicon Valley with offices in San Francisco and New York, concentrates on the United States, Israel, Europe, and Latin America. The split enables more focused investment strategies and tailored support for portfolio companies within each geographic area, while the firm continues to back early and growth-stage startups across sectors.

Notable Capital is a United States-based venture capital firm that backs early-to-growth stage companies across cloud infrastructure, artificial intelligence, fintech, and consumer and business applications with a global footprint in the United States, Israel, Europe and Latin America. The firm emphasizes backing notable founders from idea to exit and leverages 25 years of experience to support portfolio companies as they scale. It manages about $5 billion in assets and has a track record of IPOs from its portfolio. Notable Capital seeks opportunities in the evolving AI landscape, including security, design tooling, and the future of work, and its portfolio includes names such as Quince, Slack, Vercel, Zendesk, HashiCorp, Airbnb, and Affirm.

Kudu Investment Management is a New York-based investment firm that provides permanent capital solutions to independent asset and wealth management firms. It makes minority stake investments designed to facilitate ownership transfers, partner liquidity, management buyouts, and acquisition or growth financing, while enabling managers to retain control and independence. The firm emphasizes a long-term partnership approach, offering risk-sharing capital and value-add services to support growth without imposing liquidity mandates. Founded in 2015, Kudu aims to align its interests with existing principals and to back firms through flexible capital and strategic collaboration, acting as a steady partner rather than a traditional exit-focused investor.

Great North Ventures is a venture capital firm based in Maple Grove, Minnesota, founded in 2017. It focuses on early-stage investments in vertical AI and embedded finance, seeking disruptive technology companies across the United States from seed to Series B. The firm provides guidance, capital, and connections, emphasizing execution over hype. It targets startups outside Silicon Valley and is led by former operators with experience building and scaling companies. It has raised multiple funds and invested in over 50 startups.

Define Ventures is an early-stage venture capital firm focused on digital health, based in San Francisco and founded in 2019. It invests in digital health, wellness, AI-driven clinical care, and LGBTQIA+ healthcare solutions, partnering with entrepreneurs to drive meaningful improvements in healthcare. The firm emphasizes enduring partnerships, principled leadership, and leveraging a team of experienced founders, investors, and operators to provide strategic guidance and connections that accelerate growth. Define Ventures maintains a portfolio that includes Hims & Hers, Unite Us, FOLX Health, and Waltz Health.

Frontline Ventures is a Dublin-based venture capital firm with offices in London and San Francisco that backs B2B technology companies pursuing cross-Atlantic growth. It operates two funds: Frontline Seed, supporting early European startups expanding to the United States, and Frontline Growth, funding US growth-stage companies expanding into Europe, while offering strategic guidance from a team of experienced investors and operators with deep knowledge of both markets. The firm emphasizes value-added partnerships, leveraging its international network to help founders navigate global expansion, and its portfolio includes notable software and platform companies such as Workvivo, Vanta, Lattice and Navan.

Transpose Platform Management is a San Francisco-based venture capital firm and early-stage venture platform that partners with founders to build category-defining companies. Founded in 2015 by Alex Bangash and Trang T. Nguyen, it backs disruptive business models and provides more than capital by leveraging a broad network and relationships with partner funds and limited partners to offer access to resources across sectors and geographies. The firm focuses on areas such as artificial intelligence, blockchain, and quantum computing, and it supports the startup community through events and tailored investment opportunities, hosting gatherings in San Francisco, Tokyo, Abu Dhabi, and Bangalore to connect founders with operators and partner funds.

Foundry Group is a venture capital firm based in Boulder, Colorado, founded in 2007. It concentrates on early-stage technology investments, particularly information technology, Internet and software companies, across North America. The firm supports seed and early-stage ventures and operates as a registered investment adviser.

Cabra VC is a venture capital firm founded in 2016 and based in Riga, Latvia, with a global investment scope across the United States, Europe, India, and other regions. It invests across seed, early, and growth stages in high-growth technology companies in consumer, enterprise, and software sectors, with emphasis on SaaS, B2B, and subscription-based business models. The firm provides strategic support in business development, fundraising, and legal matters to help portfolio companies expand internationally.

Trinity Capital is a venture debt and equipment financing provider that supports emerging growth and venture-backed technology and high-growth companies in the United States. Working with venture capital firms, private equity, and technology lenders, it offers debt solutions including senior and subordinated term loans, asset-backed financing, equipment leases and lines of credit, and refinancing to enable strategic growth while preserving equity. The firm typically targets deals ranging from $2 million to $20 million and pursues customized structures with limited covenants, often alongside syndicate partners for larger transactions. Based in Phoenix, Arizona, Trinity Capital focuses on technology, software, hardware, healthcare, energy, and related sectors, serving revenue-generating companies across growth stages. The company emphasizes flexible capital solutions that align with portfolio companies' growth plans without significant equity dilution.

AXA Venture Partners is an independent global investment platform focused on high-growth technology companies across Europe and North America. Founded in 2016, it operates with a transatlantic approach supported by local teams in New York, London, and Paris to provide strategic guidance, connections and resources for portfolio growth. The firm engages in multi-stage investments and offers hands-on expansion support to help portfolio companies scale through partnerships, market entry strategies and operational advice. Its investment focus spans enterprise software, fintech and insurtech, digital health, AI, cybersecurity, information technology, healthcare, financial services, software-as-a-service, marketing technology, and insurance technology, backing founders as they pursue growth and expansion in diverse tech sectors.

Sound Ventures is a Beverly Hills-based venture capital firm that invests in early- and mid-stage technology companies. It operates as a registered investment adviser and emphasizes investments at the intersection of technology, culture, media, and influence.

Casdin Capital is a New York-based venture capital and investment firm focused on the life sciences and healthcare sectors. Founded in 2012 by Eli Casdin, the firm backs companies across genomic research, molecular medicine, precision medicine, diagnostics, synthetic biology, oncology, digital health, and related technologies. It pursues a data-driven, long-term investment approach and seeks to form strong partnerships with portfolio companies to advance scientific innovation and improve patient outcomes. The firm engages with ventures at various stages, from early- to late-stage private companies, emphasizing opportunities at the intersection of biology and technology. Through its activity in life sciences and healthcare, Casdin Capital positions itself as a partner to founders pursuing breakthroughs in genomics, molecular medicine, and AI-enabled healthcare platforms.

Ag Ventures Alliance accelerates Agricultural Technology innovation by connecting farmers and startup founders. It serves as an R&D partner for its 300+ farmer members, facilitates investment opportunities through Countryside Angels, conducts farm trials to test new products, and provides access to a network with over 25 years of agtech experience. The organization supports startups through the entire product development pipeline, from testing to customer acquisition, with the aim of improving resilience and profitability in American agriculture.

Firebrand Ventures is an early-stage venture capital firm focused on software startups, especially in communities underserved by traditional venture capital. Founded in 2016 and based in Overland Park, Kansas, it maintains offices in Austin and Boulder and Kansas City. The firm targets technology companies based in the United States and Canada and pursues seed- and early-stage investments, offering strategic support and partnerships to founders to help them scale.

OpenView Venture Partners is a Boston-based venture capital firm that backs expansion-stage software and technology companies. Founded in 2006, it focuses on information technology, business-to-business software and cloud technologies in North America. The firm provides post-investment operating support through its Expansion Platform, helping portfolio companies hire talent, acquire and retain customers, and scale with guidance from industry leaders. It emphasizes hands-on assistance beyond capital, including building self-service motions and support across areas such as finance, legal and corporate development to accelerate growth and help portfolio companies become market leaders.

Nassau Street Ventures is a venture capital fund for alumni of Princeton that invests in companies with a Princeton connection.

Société Générale is a multinational financial services group providing retail, corporate and investment banking, securities services and asset and wealth management. It delivers financing, advisory, market access and risk management solutions to individuals, businesses, financial institutions and public sector clients through a global network. The group pursues sustainable growth through impact financing and climate initiatives, including energy transition projects, cross-border payments and innovative technologies. It supports sectors such as agrivoltaics, infrastructure and cocoa, and embraces digital finance, including AI and stablecoins enabled services. The firm employs around 110,000 people and serves millions of clients in 58 countries with services spanning payments, cash management, custody, investment management and private banking.

Trimble is a global technology company delivering precision solutions for construction, geospatial, transportation, government, and natural resources. It provides software and hardware that connect digital and physical workflows, enabling field and mobile workers to be more productive through positioning technologies such as GPS, lasers, and optics. Its offerings include ProjectSight for construction project management, Trimble Connect for team collaboration, and Trimble SketchUp for 3D modeling, as well as AI-enabled capabilities and platform integrations. The company operates in three main areas: AECO software for architects, engineers, construction and owners; Field Systems hardware and software; and Transportation and Logistics solutions for long-haul trucking and freight. Trimble aims to streamline workflows, reduce risk, and improve project outcomes for customers worldwide. Headquartered in Sunnyvale, California, Trimble was founded in 1978.

Stanley Ventures is the corporate venture capital arm of Stanley Black & Decker, investing in early-stage startups that aim to redefine industries. It targets sectors such as software as a service, electrification, autonomy, construction technology, and advanced materials, and leverages Stanley's assets to accelerate growth. The firm provides strategic value beyond capital through industry expertise, supplier relationships, and access to Stanley Black & Decker's customer base and brand network, facilitating commercial collaborations and market validation. It often participates in syndicated rounds with other investors, aligning funding with strategic objectives and the potential to scale with Stanley's ecosystem. By combining capital with access to global distribution and technical resources, Stanley Ventures supports startups in bringing innovative solutions to practical, real-world applications, while reinforcing Stanley Black & Decker's reach into high-growth adjacent markets.

Greenspring Associates is a United States-based fund-of-funds investment firm, founded in 2000 and headquartered in Owings Mills, Maryland. It provides financial and investment advisory services and manages commingled funds and customized partnerships for a global client base, including institutions and individuals across North America, Europe, Asia, the Middle East, and Australia. The firm focuses on venture capital, investing in established and emerging fund managers as well as secondary venture capital investments, and it supports opportunities across early and growth stages of venture-backed companies. In 2021, Greenspring Associates was acquired by StepStone Group.

Western Technology Investment is a California-based venture debt firm founded in 1980 and headquartered in Portola Valley. It provides debt financing and venture lending to technology and life sciences companies at early to growth stages, offering fully usable growth capital and, in select cases, equity alongside debt. The firm emphasizes founder-friendly terms and minimizes dilution, often using warrants in client companies. Investments typically range from $250,000 to $30 million and target revenue-generating ventures with at least $25 million in annual sales within five years. Capital is raised from institutional limited partners, and the firm supports a broad portfolio across technology and life sciences, including notable names such as Facebook, Google, and Juniper Networks.

Mutual Capital Partners is a venture capital firm based in Westlake, Ohio, that backs healthcare information technology and medical device startups in Ohio and the Midwest. Beyond capital, MCP acts as a strategic partner, offering fundraising support, networking opportunities, and expert guidance to portfolio companies. The firm emphasizes strong management teams, seeks growth-ready ventures with potential for expansion, and provides due diligence assistance, customer introductions, and ongoing counsel to executives. It collaborates with angel funds and economic development entities to facilitate growth and works with portfolio companies outside major tech hubs to accelerate scale and market adoption.

Research Corporation Technologies is a biomedical technology company based in Tucson, Arizona, focused on driving life sciences innovation through the development and licensing of technologies that enable the discovery and manufacture of therapeutics and diagnostics. The company both develops its own technologies and licenses breakthrough tools to industry on a nonexclusive basis, and it collaborates with entrepreneurs, inventors, and innovators to translate biomedical inventions into commercial products. Through its RCT Ventures program, it provides experience, expertise, and funding to selected ventures. Notable offerings include CH2 Domain Scaffold ABDURINS, the ClearColi Expression System, and VIMPAT (lacosamide). It participates in industry events and seeks partnerships to accelerate translation of research into practical medical solutions.

Quiet Capital is a venture capital firm based in San Francisco, founded in 2017. It invests across a broad range of sectors including enterprise software, consumer, fintech, marketplaces, deep tech, healthcare, and crypto, seeking founders and teams with differentiated products and scalable models.

Mid-America Angels is a regional network of accredited investors that identifies and funds early-stage companies. It participates in seed, Series A, and Series B rounds depending on the capital raise and provides a framework to pool the members’ knowledge, experience, and investment capital. Founded in 2006, the organization is based in Kansas and Oklahoma and focuses on the Kansas-Missouri region around Kansas City, typically investing between $250,000 and $1,500,000 per opportunity.

Cultivian Sandbox Ventures is a Chicago-based venture capital firm that specializes in food and agriculture technology. The firm targets next-generation companies addressing critical industry challenges such as evolving demographics, globalization, sustainability, and food safety, with the goal of accelerating commercialization across the entire food and agriculture value chain. It combines industry experience with an active, hands-on approach, often serving on boards and helping portfolio companies with strategy, leadership recruitment, and capital formation. Backed by strategic partners, the firm seeks to generate value by supporting portfolio companies beyond financing, leveraging networks to foster collaboration and scale. Founded in 2008, Cultivian Sandbox aims to advance sustainable production, equitable distribution, and healthier consumption by nurturing innovations that improve efficiency, safety, and resilience within the global food system.

Primary Venture Partners is a seed and early-stage venture capital firm based in New York that backs technology companies across sectors including software, IT, enterprise SaaS, mobile, commerce, manufacturing, and energy. The firm pursues a hands-on, high-conviction approach, deploying a large operating team and a broad expert network to help founders hire, win customers, and raise future rounds. It runs a Talent Program and provides financial advisory, market development, and other support to help portfolio companies scale from seed toward Series A and beyond, with a NYC-focused origin and global reach. The firm emphasizes active involvement from seasoned operators to accelerate growth and turn ideas into scalable businesses.