Healthcare Royalty Partners

Genfit is a late-stage biopharmaceutical company specializing in the discovery and development of innovative therapeutic and diagnostic solutions for metabolic and liver-related diseases, addressing significant unmet medical needs. The company's research leverages its expertise in modulating gene expression through nuclear receptors, utilizing rational drug design to optimize drug candidates. With a strong foundation in scientific and clinical expertise, Genfit employs a translational, disease-driven approach and advanced bioinformatics capabilities to create a robust platform for drug discovery and development. Co-founded by Professor Bart Staels, a recognized expert in nuclear receptors, Genfit benefits from his leadership as chair of the Scientific Advisory Board, enhancing the company's commitment to innovation in the metabolic field. Through strategic alliances, acquisitions, and licensing agreements, Genfit seeks to fund the advancement of its products, which hinge on successful clinical development.

Esperion discovers and develops pharmaceutical products for the treatment of cardiovascular and metabolic diseases. Esperion intends to commercialize a novel class of drugs that focuses on a new treatment approach called "HDL Therapy," which is based on the Company's understanding of high-density lipoprotein, or HDL, function.

Liquidia Technologies is a late-stage clinical biopharmaceutical company based in the United States, dedicated to developing and commercializing innovative therapeutics. Utilizing its proprietary PRINT technology, a particle engineering platform, Liquidia produces uniform drug particles aimed at enhancing the safety and efficacy of various therapies. The company is advancing two key product candidates: LIQ861, intended for the treatment of pulmonary arterial hypertension, and LIQ865, designed for managing local post-operative pain. Additionally, Liquidia collaborates with leading pharmaceutical firms to leverage its PRINT technology across multiple therapeutic areas, molecule types, and administration routes, addressing unmet patient needs, particularly in the realm of pulmonary hypertension.

TG Therapeutics, Inc. is a biopharmaceutical company based in New York that specializes in the acquisition, development, and commercialization of innovative therapies for B-cell malignancies and autoimmune diseases. The company has developed a strong research and development platform focused on B-cell pathways and conducts rapid clinical testing. Its lead product, ublituximab, is a glycoengineered monoclonal antibody approved for treating relapsing forms of multiple sclerosis and is also under evaluation for non-Hodgkin lymphoma and chronic lymphocytic leukemia. Additionally, TG Therapeutics is advancing therapies such as TG-1701, a selective Bruton’s tyrosine kinase inhibitor, and TG-1801, a bispecific antibody targeting CD47 and CD19. The company maintains various strategic alliances to support its research initiatives and has several preclinical programs in development targeting additional therapeutic areas.

OPKO Health, Inc. is a multinational healthcare company that operates in the diagnostics and pharmaceuticals sectors. Its Diagnostics segment includes BioReference Laboratories, which provides a range of laboratory testing services, including core genetic testing and the 4Kscore prostate cancer test. The Pharmaceuticals segment offers several treatments, including Rayaldee for secondary hyperparathyroidism, and is developing drugs such as OPK88004, a selective androgen receptor modulator, and OPK88003 for type 2 diabetes and obesity. Additionally, OPKO is advancing hGH-CTP, a once-weekly human growth hormone injection, and has various products targeting chemotherapy-induced nausea, hemophilia, and other medical conditions. The company also engages in the development and commercialization of specialty active pharmaceutical ingredients and a range of pharmaceutical, nutraceutical, and veterinary products. With operations spanning countries such as Ireland, Chile, Spain, and Mexico, OPKO Health focuses on leveraging its proprietary technologies and expertise to grow in key medical markets. Headquartered in Miami, Florida, OPKO Health was incorporated in 1991.

Zevra Therapeutics is a development-stage biopharmaceutical company focused on creating new therapies for pain, ADHD, and other central nervous system (CNS) diseases, particularly in the realm of rare diseases. The company is dedicated to developing safer, abuse-resistant opioid pain relievers and employs a proprietary Ligand Activated Therapy (LAT) approach to drug discovery and development. This innovative platform allows Zevra to enhance existing medications and streamline the development process while preserving strong intellectual property rights. By integrating scientific research with patient needs and data-driven strategies, Zevra Therapeutics aims to address the challenges of drug development, delivering transformational therapies for conditions with limited or no treatment options.

Liquidia Technologies is a late-stage clinical biopharmaceutical company based in the United States, dedicated to developing and commercializing innovative therapeutics. Utilizing its proprietary PRINT technology, a particle engineering platform, Liquidia produces uniform drug particles aimed at enhancing the safety and efficacy of various therapies. The company is advancing two key product candidates: LIQ861, intended for the treatment of pulmonary arterial hypertension, and LIQ865, designed for managing local post-operative pain. Additionally, Liquidia collaborates with leading pharmaceutical firms to leverage its PRINT technology across multiple therapeutic areas, molecule types, and administration routes, addressing unmet patient needs, particularly in the realm of pulmonary hypertension.

Cara Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in Stamford, Connecticut, specializing in the development and commercialization of innovative therapeutics for pain and pruritus. The company primarily focuses on its lead product candidate, CR845 (difelikefalin), which is designed to selectively target kappa opioid receptors and is currently undergoing Phase III clinical trials for treating moderate-to-severe chronic kidney disease-associated pruritus in patients undergoing hemodialysis. Cara is also advancing Oral KORSUVA, which has completed Phase II trials for pruritus in chronic kidney disease and is in trials for pruritus associated with chronic liver disease and atopic dermatitis. Furthermore, the company is developing CR845/difelikefalin Injection for acute postoperative pain, having completed Phase II/III trials. Cara Therapeutics collaborates with Maruishi Pharmaceutical Co., Ltd. and Chong Kun Dang Pharmaceutical Corporation for the development and commercialization of its product candidates in Japan and South Korea, respectively. Founded in 2004, Cara Therapeutics aims to leverage its proprietary drug screening technology to create a pipeline of first-in-class therapeutics.

Liquidia Technologies is a late-stage clinical biopharmaceutical company based in the United States, dedicated to developing and commercializing innovative therapeutics. Utilizing its proprietary PRINT technology, a particle engineering platform, Liquidia produces uniform drug particles aimed at enhancing the safety and efficacy of various therapies. The company is advancing two key product candidates: LIQ861, intended for the treatment of pulmonary arterial hypertension, and LIQ865, designed for managing local post-operative pain. Additionally, Liquidia collaborates with leading pharmaceutical firms to leverage its PRINT technology across multiple therapeutic areas, molecule types, and administration routes, addressing unmet patient needs, particularly in the realm of pulmonary hypertension.

Clearside Biomedical, Inc. is a biopharmaceutical company focused on developing treatments for serious eye diseases with the aim of restoring and preserving vision. Founded in 2011 and headquartered in Alpharetta, Georgia, the company specializes in a proprietary ocular microinjection platform that allows for targeted delivery of therapeutic products to specific compartments of the eye. This innovative approach includes the use of the SCS Microinjector for administering therapies directly into the suprachoroidal space, enabling a non-surgical, repeatable procedure. Among its product pipeline, Clearside is developing XIPERE, a triamcinolone acetonide injectable suspension for macular edema, and CLS-AX, an axitinib for suprachoroidal injection. The company is dedicated to advancing pharmacological therapies for sight-threatening conditions by ensuring precise and effective treatment delivery.

Ardelyx, Inc. is a biopharmaceutical company based in Fremont, California, specializing in the development and commercialization of innovative oral therapeutics for cardiorenal diseases. Founded in 2007, Ardelyx focuses on addressing significant unmet medical needs with its proprietary drug discovery platform. The company's lead product candidate, tenapanor, has completed Phase 3 clinical trials for the treatment of irritable bowel syndrome with constipation and is also being evaluated for hyperphosphatemia in end-stage renal disease patients on dialysis. In addition, Ardelyx is advancing RDX013, a potassium secretagogue aimed at treating hyperkalemia, and other candidates including RDX002, a phosphate transport inhibitor for chronic kidney disease, and RDX009, an agonist for type 2 diabetes, which are currently in preclinical development. Ardelyx's approach emphasizes the creation of minimally absorbed medications that target specific receptors and transporters, thereby reducing the risk of systemic side effects.

Rhythm Pharmaceuticals, Inc. is a biopharmaceutical company dedicated to the development and commercialization of therapeutics for rare genetic disorders, particularly those that lead to life-threatening metabolic conditions. The company’s primary product candidate, setmelanotide, is a first-in-class melanocortin-4 receptor agonist currently undergoing Phase III clinical trials for the treatment of obesity related to pro-opiomelanocortin (POMC) and leptin receptor deficiencies, as well as Bardet-Biedl and Alström syndromes. Additionally, it is in Phase II trials for various other genetic obesity disorders. Rhythm Pharmaceuticals is also advancing RM-853, an orally available ghrelin o-acyltransferase inhibitor in preclinical development aimed at addressing Prader-Willi syndrome. Founded in 2008 and based in Boston, Massachusetts, the company previously operated under the name Rhythm Metabolic, Inc. and rebranded in October 2015.

Spero Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, dedicated to developing innovative treatments for multi-drug resistant (MDR) bacterial infections and rare diseases. Founded in 2013, the company is advancing several product candidates, including tebipenem pivoxil hydrobromide, an oral carbapenem-class antibiotic aimed at treating MDR gram-negative infections in adults. Additionally, Spero is developing SPR206, an intravenous agent for MDR gram-negative infections in hospital settings, and SPR720, an oral antibiotic targeting pulmonary non-tuberculous mycobacterial disease. The company collaborates with various partners, including Meiji Seika Pharma to support tebipenem HBr's development and the Bill & Melinda Gates Medical Research Institute for SPR720. Spero Therapeutics employs a focused approach to drug development, emphasizing novel mechanisms to address the urgent need for effective therapeutics against serious bacterial infections.

Portola Pharmaceuticals, Inc. is a biopharmaceutical company based in South San Francisco, California, specializing in the development and commercialization of innovative therapeutics for thrombosis, hematologic disorders, and inflammation. Founded in 2003, Portola's lead product, Andexxa, serves as an antidote for patients treated with rivaroxaban and apixaban. The company's portfolio also includes Bevyxxa, an oral Factor Xa inhibitor designed to prevent venous thromboembolism in adults with acute medical illnesses. Additionally, Portola is developing investigational therapies such as cerdulatinib, a dual inhibitor targeting spleen tyrosine kinase and Janus kinases for hematologic cancers, and various Syk inhibitors for chronic inflammatory diseases. Portola collaborates with several major pharmaceutical companies to enhance its research and development efforts. As of July 2020, Portola operates as a subsidiary of Alexion Pharmaceuticals, Inc.

Coherus Biosciences is a biopharmaceutical company that specializes in the development, manufacture, and commercialization of biologic therapeutics, with a strong emphasis on oncology and inflammatory diseases. The company is actively engaged in research and development, focusing on process science, analytical characterization, and protein production. Coherus's portfolio includes FDA-approved products such as UDENYCA, a biosimilar of Neulasta, and it plans to launch YUSIMRY, a biosimilar of Humira, in the United States. Additionally, the company is advancing a pipeline of biosimilar candidates across areas such as immunology and ophthalmology, as well as anti-tumor necrosis factor treatments. With a commitment to building an immuno-oncology franchise, Coherus aims to leverage its diversified portfolio to generate revenue and enhance patient access to biologic therapies.

TearScience, Inc. is a medical device company based in Morrisville, North Carolina, specializing in the identification, diagnosis, and treatment of meibomian gland disease (MGD), a primary cause of dry eye affecting millions worldwide. Founded in 2005, TearScience has developed innovative devices to address evaporative dry eye, including the LipiFlow Activator, which delivers automated therapeutic energies to treat the meibomian glands, and the LipiScan, an imaging tool that allows eye care professionals to assess gland health. The company's integrated system enables effective management of MGD, which is often underestimated despite being a leading contributor to dry eye symptoms such as irritation, dryness, and visual disturbances. As a subsidiary of Johnson & Johnson Surgical Vision, TearScience continues to advance its mission of improving patient outcomes through early detection and treatment of this chronic condition.

Invuity, Inc. is a medical technology company based in San Francisco, California, specializing in the development and marketing of surgical devices designed for enhanced visualization during minimally invasive procedures. Founded in 2004, the company utilizes advanced photonics technology to create illuminated surgical devices that provide surgeons with improved illumination and direct visualization of surgical cavities. Its product offerings include various illuminated retractor systems and handheld illuminators suitable for multiple surgical specialties, such as orthopedics, gynecology, and plastic surgery. Notable products include the Eikon LT illuminated retractor system, the PhotonBlade illuminator, and the BriteField Port System, all designed to enhance precision, efficiency, and safety during surgical procedures. Invuity sells its devices through a combination of direct sales representatives, independent agents, and directly to hospitals and surgeons. The company was previously known as Spotlight Surgical, Inc. and adopted its current name in 2007. As of 2018, Invuity operates as a subsidiary of Stryker Corporation.

Helomics Corporation is a personalized healthcare company based in Pittsburgh, Pennsylvania, focused on enhancing cancer care through a range of innovative diagnostic products and services. The company has developed the Precision Cellular Analytical Platform, which analyzes cell cycle and proliferation data over a 25-35 day period. Helomics' offerings include ChemoFx, which assists in selecting effective treatments for gynecologic cancer, and BioSpeciFx, a set of biomarker tests that provide insights into tumor characteristics and potential drug responses. Additionally, Helomics provides GeneFx Colon and GeneFx Lung, microarray-based gene signatures tailored for patients with stage two colon cancer and early-stage non-small cell lung cancer, respectively. The company also engages in tumor profiling services, including bioinformatics and contract research, to support clinical decision-making. Furthermore, Helomics utilizes its D-CHIP digital clinical health insight platform to deliver personalized oncology roadmaps and collaborates with pharmaceutical and diagnostics companies to enhance patient selection for clinical trials. Founded in 1995 and formerly known as Precision Therapeutics, Helomics continues to push the boundaries of precision oncology.

Cardiorentis AG is a biopharmaceutical company based in Zug, Switzerland, focused on developing innovative drug therapies for acute heart failure and related cardiovascular diseases. Founded in 2010, the company is dedicated to advancing novel treatment options, particularly through its key product, ularitide, which is designed for intravenous infusion in patients suffering from acute heart failure. In addition to its primary focus on ularitide, Cardiorentis conducts comprehensive studies, including safety and efficacy trials for patients with symptomatic and decompensated chronic heart failure. The company's approach combines expertise in protein biology with the development of small molecule compounds and peptides, aimed at addressing significant unmet medical needs in cardiology. Through collaborations with academic researchers, universities, and healthcare professionals, Cardiorentis is committed to driving impactful research that enhances patient care in a rapidly evolving medical landscape.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at improving near vision. Founded in 2001, the company develops and markets innovative solutions for presbyopia, including the KAMRA inlay, which helps patients restore their near vision without compromising distance vision. Additionally, AcuFocus offers the IC-8 IOL, a small aperture lens designed for cataract patients, providing a broad range of vision from near to far distances. The company also produces the AcuTarget HD, a diagnostic and surgical planning instrument that assists in the optimal treatment selection for various eye conditions such as LASIK, cataracts, and dry eye. AcuFocus distributes its products through partners across the Americas, Asia-Pacific, Europe, and the Middle East, serving both physicians and patients in the vision care market.

Raptor Pharmaceuticals Corp. is a development stage biotechnology company based in Novato, California, focused on discovering and developing innovative drug candidates for various serious conditions, including brain disorders, neurodegenerative diseases, genetic disorders, and cancers. The company is advancing several clinical-stage products, including DR Cysteamine, which is undergoing Phase IIb trials for nephropathic cystinosis and Phase IIa trials for non-alcoholic steatohepatitis, as well as Convivia for ALDH2 deficiency and additional candidates targeting Huntington's disease and migraine. Raptor is also engaged in preclinical development of therapies such as HepTide for hepatocellular carcinoma, WntTide for breast cancer, and NeuroTrans for neurodegenerative diseases. The company collaborates with academic institutions, including the University of California, San Diego, to enhance its research and clinical studies. Founded in 2005, Raptor Pharmaceuticals is dedicated to developing bio-pharmaceutical therapies aimed at treating debilitating and life-threatening diseases.

Invuity, Inc. is a medical technology company based in San Francisco, California, specializing in the development and marketing of surgical devices designed for enhanced visualization during minimally invasive procedures. Founded in 2004, the company utilizes advanced photonics technology to create illuminated surgical devices that provide surgeons with improved illumination and direct visualization of surgical cavities. Its product offerings include various illuminated retractor systems and handheld illuminators suitable for multiple surgical specialties, such as orthopedics, gynecology, and plastic surgery. Notable products include the Eikon LT illuminated retractor system, the PhotonBlade illuminator, and the BriteField Port System, all designed to enhance precision, efficiency, and safety during surgical procedures. Invuity sells its devices through a combination of direct sales representatives, independent agents, and directly to hospitals and surgeons. The company was previously known as Spotlight Surgical, Inc. and adopted its current name in 2007. As of 2018, Invuity operates as a subsidiary of Stryker Corporation.

Nuron Biotech Inc. develops specialty biologics and vaccines. Its product pipeline comprises central nervous system products, such as NU100, a recombinant human interferon beta-1b for the treatment of relapsing remitting multiple sclerosis; wound healing products, including NU200, a recombinant human epidermal growth factor product for healing diabetic foot ulcers and burns; and HibTITER, a conjugate vaccine. The company was founded in 2010 and is based in Exton, Pennsylvania.

Suneva Medical, Inc. is a medical technology company based in San Diego, California, specializing in the development, manufacturing, and commercialization of innovative aesthetic products for the dermatology, plastic, and cosmetic surgery markets. The company’s flagship product, Bellafill, is a unique dermal filler that boasts five-year safety and efficacy data and is approved for correcting facial acne scars in addition to treating nasolabial folds. Suneva Medical also offers Puregraft, a fat grafting solution that enhances long-term graft retention, as well as a platelet-rich plasma platform for optimal platelet concentrate processing and Silhouette InstaLift resorbable sutures for cosmetic facial procedures. Founded in 2008, Suneva Medical aims to provide differentiated products that enhance patient satisfaction and create significant opportunities for healthcare practitioners.

Suneva Medical, Inc. is a medical technology company based in San Diego, California, specializing in the development, manufacturing, and commercialization of innovative aesthetic products for the dermatology, plastic, and cosmetic surgery markets. The company’s flagship product, Bellafill, is a unique dermal filler that boasts five-year safety and efficacy data and is approved for correcting facial acne scars in addition to treating nasolabial folds. Suneva Medical also offers Puregraft, a fat grafting solution that enhances long-term graft retention, as well as a platelet-rich plasma platform for optimal platelet concentrate processing and Silhouette InstaLift resorbable sutures for cosmetic facial procedures. Founded in 2008, Suneva Medical aims to provide differentiated products that enhance patient satisfaction and create significant opportunities for healthcare practitioners.

TearScience, Inc. is a medical device company based in Morrisville, North Carolina, specializing in the identification, diagnosis, and treatment of meibomian gland disease (MGD), a primary cause of dry eye affecting millions worldwide. Founded in 2005, TearScience has developed innovative devices to address evaporative dry eye, including the LipiFlow Activator, which delivers automated therapeutic energies to treat the meibomian glands, and the LipiScan, an imaging tool that allows eye care professionals to assess gland health. The company's integrated system enables effective management of MGD, which is often underestimated despite being a leading contributor to dry eye symptoms such as irritation, dryness, and visual disturbances. As a subsidiary of Johnson & Johnson Surgical Vision, TearScience continues to advance its mission of improving patient outcomes through early detection and treatment of this chronic condition.

Nuron Biotech Inc. develops specialty biologics and vaccines. Its product pipeline comprises central nervous system products, such as NU100, a recombinant human interferon beta-1b for the treatment of relapsing remitting multiple sclerosis; wound healing products, including NU200, a recombinant human epidermal growth factor product for healing diabetic foot ulcers and burns; and HibTITER, a conjugate vaccine. The company was founded in 2010 and is based in Exton, Pennsylvania.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at improving near vision. Founded in 2001, the company develops and markets innovative solutions for presbyopia, including the KAMRA inlay, which helps patients restore their near vision without compromising distance vision. Additionally, AcuFocus offers the IC-8 IOL, a small aperture lens designed for cataract patients, providing a broad range of vision from near to far distances. The company also produces the AcuTarget HD, a diagnostic and surgical planning instrument that assists in the optimal treatment selection for various eye conditions such as LASIK, cataracts, and dry eye. AcuFocus distributes its products through partners across the Americas, Asia-Pacific, Europe, and the Middle East, serving both physicians and patients in the vision care market.

Zogenix, Inc. is a pharmaceutical company focused on developing and commercializing innovative therapies for patients with rare diseases, particularly within the central nervous system. The company is headquartered in Emeryville, California, and was established in 2006. Its lead product candidate, Fintepla, is a low-dose fenfluramine currently undergoing Phase III clinical trials for the treatment of seizures related to Dravet syndrome and Lennox-Gastaut syndrome. Additionally, it is being investigated in Phase II trials for other rare epileptic conditions. Zogenix is also developing MT1621, a therapy aimed at treating inherited mitochondrial DNA depletion disorders. Furthermore, the company collaborates with Tevard Biosciences to explore gene therapies for Dravet syndrome and similar genetic epilepsies. By focusing on therapies that address significant unmet medical needs, Zogenix aims to enhance the quality of life for patients and their families.