Ankyra is a biotech company developing anchored immunotherapy for cancer treatments. Systemic dosing of these potent immune stimulants is restricted due to widespread immune activation and toxicity. When cytokines are injected into tumor tissue, they localize specifically and persistently, causing intense hot spots of inflammation that activate an anti-tumor immune response. Ankyra used its Anchored Immunotherapy Platform to develop ANK-101, a stable complex of a modified IL-12 cytokine with aluminum hydroxide (Alhydrogel) to overcome the limitations of traditional cytokine therapeutics. Alhydrogel, an FDA-approved adjuvant for use in human and veterinary vaccines, acts as a scaffold to locally retain the potent activity of IL-12 after intratumoral administration, improving its therapeutic window. Ankyra's mission is to optimize the impact of anchored immunotherapy to improve the lives of patients with cancer.
Orbit Discovery is a peptide display company identifying potential peptide drugs for a range of chronic diseases. Peptides offer the potential to make drugs with the specificity and efficacy of large biologic molecules combined with the smaller dose size, simpler routes of delivery and lower cost of manufacturing found with small molecules. They are, therefore, uniquely suited to the treatment of chronic diseases which impact large patient populations. Their technology supports all of the improvements that can be made to peptides which make them better drugs whilst simplifying the discovery process and accelerating drug development
Ovation provides data and operations solutions to researchers, scientists, and labs throughout the life sciences industry that allow researchers to describe and visualize the relationships between their data.
FidoCure is transforming canine cancer care through AI-driven precision medicine. By harnessing data from naturally occurring canine cancers via next-generation sequencing and clinical information, FidoCure has developed the world's largest proprietary learning database for canine cancer. FidoCure is pioneering first-in-class care for canine cancer, which represents the largest unmet need for pet dogs. By connecting human and veterinary oncology, FidoCure enhances comparative oncology, improves outcomes across species, and creates new opportunities for drug development that benefit both pets and humans.
Ovation provides data and operations solutions to researchers, scientists, and labs throughout the life sciences industry that allow researchers to describe and visualize the relationships between their data.
Teckro is a life science technology company that is rethinking every element of clinical research - the people, the processes, and the technologies used. By making it possible for all relevant information to be instantly accessible to every active member of a clinical trial and for the entire study teams to be connected effortlessly, Teckro is broadening the possibilities of what they can achieve. Teckro's solutions result in quicker development of drugs and treatments for the world’s most complex diseases. The company was founded in 2015 and is based in Limerick, Ireland with offices in Dublin and Nashville.
Evox Therapeutics is a privately held, Oxford-based biotechnology company focused on harnessing and engineering the natural delivery capabilities of extracellular vesicles, known as exosomes, to develop an entirely new class of therapeutics. Backed by leading Life Sciences Venture Capital groups and supported by a comprehensive intellectual property portfolio, Evox’s mission is to positively impact human health by creating novel exosome-based therapeutics for the treatment of various severe diseases with limited options for patients and their families. Evox has created substantial proprietary technology to modify exosomes using various molecular engineering, drug loading, and targeting strategies to facilitate targeted drug delivery to organs of interest, including the brain and the central nervous system. Exosome-based drugs have the potential to address some of the limitations of protein, antibody and nucleic acid-based therapies by enabling delivery to cells and tissues that are currently out of reach using other drug delivery technologies. Evox is leading the development within this emerging therapeutic space.
Compass Therapeutics, Inc. is a clinical-stage biopharmaceutical company, developing antibody therapeutics to treat both solid tumors and hematologic malignancies. Compass is leveraging its proprietary StitchMabs™ and common light-chain enabled multispecific platforms to empirically identify multispecifics and combinations of antibody therapeutics that can be advanced to the clinic. The company's lead product candidate, CTX-009, is a bispecific antibody, which inhibits both DLL4-mediated Notch signaling and VEGF-A signaling. CTX-009 has completed a Phase 1 dose escalation study and is in a Phase 1b study in combination with chemotherapy in patients with solid tumors. The company’s second product candidate, CTX-471, is a novel agonistic antibody of CD137, a co-stimulatory receptor on immune cells. It is currently being evaluated in a Phase 1b study in patients who were previously treated with PD-1/PD-L1 checkpoint inhibitors, and who subsequently relapsed or progressed after a period of stable disease. Compass’ third product candidate, CTX-8371, is a bispecific antibody that blocks both PD-1 and PD-L1 and is in IND-enabling studies. The company was founded in 2014 and is headquartered in Boston, Massachusetts.
Orbit Discovery is a peptide display company identifying potential peptide drugs for a range of chronic diseases. Peptides offer the potential to make drugs with the specificity and efficacy of large biologic molecules combined with the smaller dose size, simpler routes of delivery and lower cost of manufacturing found with small molecules. They are, therefore, uniquely suited to the treatment of chronic diseases which impact large patient populations. Their technology supports all of the improvements that can be made to peptides which make them better drugs whilst simplifying the discovery process and accelerating drug development
Measurabl develops an ESG data management platform for commercial real estate. It empowers customers to optimize ESG performance, assess exposure to physical climate risk, drive decarbonization, and secure sustainable finance opportunities.
Dandelion Energy, Inc., founded in 2017 and headquartered in Palo Alto, California, specializes in affordable geothermal heating and cooling solutions for residential properties. The company's innovative home geothermal system replaces traditional air conditioning and heating equipment with a heat pump and underground pipes that efficiently transfer thermal energy between the earth and the home. This proprietary installation process allows homeowners to transition from conventional heating fuels to renewable geothermal energy, providing an environmentally friendly and cost-effective alternative for temperature regulation and hot water production.
Avitide develops customized biopharmaceutical affinity purification products with an industry-leading discovery and development service timeline. The Avitide platform reduces process development timelines, program risks, and cost of production by providing high-resolution custom affinity purification solutions. The company was founded in 2012 and is based in Lebanon, New Hampshire.
Newmetrix develops a cloud-based video management platform to reduce jobsite risk with the power of human and artificial intelligence.
HELIX, formerly Flux, was the first spin-out of Google X. Initially focused on generative building design to automate planning and design of sustainable buildings, HELIX pivoted in 2019 to attack the high cost and complexity of digitizing buildings. Based in Oakland, CA, HELIX built the HELIX Creator platform to enable architects, engineers, builders, and owner-operators to use LiDAR and photogrammetry to capture accurate building geometry and convert it into usable plans and models. HELIX users need accurate 2D and 3D information and access to documents and data related to the building without delays. HELIX is used to evaluate buildings' potential, plan for renovation, document buildings in detail for disaster planning and more. HELIX believes that for Digital Twins to achieve their potential the data must be accurate, intuitive to access and easy to keep up to date.
Avitide develops customized biopharmaceutical affinity purification products with an industry-leading discovery and development service timeline. The Avitide platform reduces process development timelines, program risks, and cost of production by providing high-resolution custom affinity purification solutions. The company was founded in 2012 and is based in Lebanon, New Hampshire.
Compass Therapeutics, Inc. is a clinical-stage biopharmaceutical company, developing antibody therapeutics to treat both solid tumors and hematologic malignancies. Compass is leveraging its proprietary StitchMabs™ and common light-chain enabled multispecific platforms to empirically identify multispecifics and combinations of antibody therapeutics that can be advanced to the clinic. The company's lead product candidate, CTX-009, is a bispecific antibody, which inhibits both DLL4-mediated Notch signaling and VEGF-A signaling. CTX-009 has completed a Phase 1 dose escalation study and is in a Phase 1b study in combination with chemotherapy in patients with solid tumors. The company’s second product candidate, CTX-471, is a novel agonistic antibody of CD137, a co-stimulatory receptor on immune cells. It is currently being evaluated in a Phase 1b study in patients who were previously treated with PD-1/PD-L1 checkpoint inhibitors, and who subsequently relapsed or progressed after a period of stable disease. Compass’ third product candidate, CTX-8371, is a bispecific antibody that blocks both PD-1 and PD-L1 and is in IND-enabling studies. The company was founded in 2014 and is headquartered in Boston, Massachusetts.
Adored is a loyalty experience platform that is strengthening the relationships users have with the businesses they visit and the brands they love. The Adored app uses iBeacon indoor location technology to automatically reward customers and immerse them in experiences that enhance each visit. These remarkable experiences are what build brand loyalty and advocacy, and ultimately increase the lifetime value of each customer. Adored has been downloaded over 10,000 times and is active at dozens of locations ranging from ski resorts and arenas to cafes and bars. The company was founded in 2014 and is based in Manchester, New Hampshire.
Fieldlens offers a tool that improves communication and collaboration for construction project teams. It knows what each member of the team needs to do now and reminds them, and it gives decision-makers a bird’s-eye view of every project without stepping on-site, enabling them to spot trends and see who the best performers are.
HELIX, formerly Flux, was the first spin-out of Google X. Initially focused on generative building design to automate planning and design of sustainable buildings, HELIX pivoted in 2019 to attack the high cost and complexity of digitizing buildings. Based in Oakland, CA, HELIX built the HELIX Creator platform to enable architects, engineers, builders, and owner-operators to use LiDAR and photogrammetry to capture accurate building geometry and convert it into usable plans and models. HELIX users need accurate 2D and 3D information and access to documents and data related to the building without delays. HELIX is used to evaluate buildings' potential, plan for renovation, document buildings in detail for disaster planning and more. HELIX believes that for Digital Twins to achieve their potential the data must be accurate, intuitive to access and easy to keep up to date.
Sketchfab is empowering a new era of creativity by making it easy for anyone to publish and find 3D content online. With a community of millions of creators who have published millions of models, it serves as a platform for immersive and interactive 3D. Additionally, its store lets buyers and sellers transact 3D models with confidence using our real-time viewer and model inspector.
Newforma develops, sells, and supports project information management (PIM) software for architecture, engineering, and construction firms worldwide, and the owners they serve. Newforma’s mission is to transform the AEC industry as the first industry-focused and integrated solution to connect firms to each other, to their project information, to their processes, and to remote team members, all for the purpose of more successful project delivery. Customers are using Newforma software to manage information on more than 1.4 million projects worldwide, raising productivity, reducing exposure to risk, strengthening their brands, and freeing time and attention to focus on design, construction, and client service. The company was founded in 2003 and is based in Boston.
Avedro is a privately held medical device and pharmaceutical company advancing the science and technology of corneal cross-linking. Avedro recently completed its US‐based, multi-centered, Phase III studies of corneal cross-linking for the treatment of progressive keratoconus and corneal ectasia following refractive surgery. Outside the United States, Avedro has commercialized both VibeX and its KXL System for performing Lasik Xtra and accelerated cross-linking. Additionally, Avedro is developing the science of Thermo‐biomechanics for therapeutic medical applications. The Keraflex® refractive correction procedure is the first technology developed from the Thermo‐biomechanics platform and is a non‐invasive, incision‐less ophthalmic procedure for flattening the cornea without the removal of tissue. Keraflex offers the unique ability to induce refractive change without weakening the cornea’s biomechanical integrity, as happens with Lasik and other refractive correction procedures. Keraflex is commercially available outside of the United States.
Avitide develops customized biopharmaceutical affinity purification products with an industry-leading discovery and development service timeline. The Avitide platform reduces process development timelines, program risks, and cost of production by providing high-resolution custom affinity purification solutions. The company was founded in 2012 and is based in Lebanon, New Hampshire.
Mosaic Storage Systems is a provider of digital asset storage services used to help professional photographers to store their photographs. Its digital asset storage services take digital copies of photographs, stores them on its servers, and make them accessible via the internet that enables users to store and share photographs securely. It was founded in 2011 and is based in Nashua, New Hampshire.
Airstone is a developing a specialized IaaS offering for Big Data customers. The company has developed a proprietary networking fabric called Ultramarine that provides a significant price performance advantage over existing datacenter networking fabrics. Ultramarine offers the lowest latency and highest bandwidth per node on the market.
Vets First Choice provides veterinary practices with an online pharmacy and home delivery services. It partners with veterinarians to create insight into gaps in patient care and offer professionalized pro-active prescription management to drive client engagement and improve compliance. The company was founded by Ben Shaw in 2010 and is based in Portland, Maine.
PCD Partners is a group of world class physicians, academics, and entrepreneurs who have decades of experience with collaboration in medical quality and practice improvement systems for large scale practice management and clinical practice improvement.
Wingu is building a metrics-driven system for optimizing outsourced pharmaceutical research. They simplify information exchange for researchers; deliver robust project insight for managers and provide deep analytics for executives to enable better, faster decisions.
enVista is the leading enterprise cost management services provider, offering expert consulting and technology services from source to consumption. enVista enables leading companies to reduce operating costs, improve customer service and enhance profitability through innovative solutions and deep domain expertise across a multitude of industries and vertical markets.
SpaceClaim Corporation develops and markets 3D direct modeling software solutions that help engineers, CAE analysts, product designers, and manufacturers in the product development process. It offers SpaceClaim Engineer that enables engineers to create concepts and prepare 3D designs for prototyping, analysis, and manufacturing; SpaceClaim Style, an industrial design tool that is used to create, edit, and validate design concepts; SpaceClaim Viewer, which enables its users to open and measure SpaceClaim designs, drawings, and 3D markups; and add-on modules and plug-ins for SpaceClaim software. The company also provides educational licenses for its software solutions to professors, instructors, and educational institutions in North America, as well as training programs for its software. Its products are used for conceptual engineering, CAE/model preparation, industrial design, and manufacturing engineering applications. The company offers its products through a network of resellers in the United States and internationally. SpaceClaim Corporation was founded in 2005 and is headquartered in Concord, Massachusetts with additional offices in France and Japan.
enVista is the leading enterprise cost management services provider, offering expert consulting and technology services from source to consumption. enVista enables leading companies to reduce operating costs, improve customer service and enhance profitability through innovative solutions and deep domain expertise across a multitude of industries and vertical markets.
Adimab's integrated antibody discovery and optimization platform provides unprecedented speed from antigen to purified, full-length human IgGs. Adimab offers fundamental advantages by delivering diverse panels of therapeutically relevant antibodies that meet the most aggressive standards for affinity, epitope coverage, species cross-reactivity and expressability. Adimab enables its partners to rapidly expand their biologics pipelines through a broad spectrum of technology access arrangements.
Vico Software, provides software and services to the building construction industry in Europe, the Middle East, and the Americas. The company offers Vico Office Suite, a construction-oriented 5D BIM environment; Vico Office Client that publishes 3D models from BIM authoring tools, as well as enables the client to integrate and merge multiple models from various BIM sources; and Vico Takeoff Manager that generates the accurate model-and location-based quantity takeoffs derived from 3D models. It also provides Vico Cost Planner, a cost calculation, estimating, and value engineering module; Vico Cost Explorer, which provides constant and online feedback about the status of project budget; Vico Office Online Training Program, an e-learning platform that is designed to guide the client through the Vico Office Platform; and Vico Doc Set Manager that collates and compares drawing set pages with a mouse click. In addition, the company offers project services delivery, service packages, and implementation and consulting services. Its software solutions are used by building owners, general contractors, and construction managers. The company was founded in 2007 and is based in Boulder, Colorado with additional offices in the United States, the United Kingdom, Finland, and Hungary.
enVista is the leading enterprise cost management services provider, offering expert consulting and technology services from source to consumption. enVista enables leading companies to reduce operating costs, improve customer service and enhance profitability through innovative solutions and deep domain expertise across a multitude of industries and vertical markets.
SpaceClaim Corporation develops and markets 3D direct modeling software solutions that help engineers, CAE analysts, product designers, and manufacturers in the product development process. It offers SpaceClaim Engineer that enables engineers to create concepts and prepare 3D designs for prototyping, analysis, and manufacturing; SpaceClaim Style, an industrial design tool that is used to create, edit, and validate design concepts; SpaceClaim Viewer, which enables its users to open and measure SpaceClaim designs, drawings, and 3D markups; and add-on modules and plug-ins for SpaceClaim software. The company also provides educational licenses for its software solutions to professors, instructors, and educational institutions in North America, as well as training programs for its software. Its products are used for conceptual engineering, CAE/model preparation, industrial design, and manufacturing engineering applications. The company offers its products through a network of resellers in the United States and internationally. SpaceClaim Corporation was founded in 2005 and is headquartered in Concord, Massachusetts with additional offices in France and Japan.
FetchDog is an online destination for dog owners to shop, learn and socialize. They offer passionate dog people a place to find quality dog supplies and credible advice on their dog’s health and wellness. Their products include pets, dog beds, dog homes, dog collars, leashes and harnesses, dog apparel, dog toys, treats, bowls, dog travel, and more.
Adimab's integrated antibody discovery and optimization platform provides unprecedented speed from antigen to purified, full-length human IgGs. Adimab offers fundamental advantages by delivering diverse panels of therapeutically relevant antibodies that meet the most aggressive standards for affinity, epitope coverage, species cross-reactivity and expressability. Adimab enables its partners to rapidly expand their biologics pipelines through a broad spectrum of technology access arrangements.
Newforma develops and supports project information management (PIM) software tailored for the architecture, engineering, and construction (AEC) sectors. Founded in 2003 and headquartered in Manchester, New Hampshire, the company's mission is to enhance collaboration among firms, streamline project information, and integrate processes for improved project delivery. Newforma's solutions facilitate collaboration among owners, designers, builders, and extended construction teams through mobile, cloud, and desktop applications. The software is utilized to manage information on over 1.4 million projects globally, which helps clients increase productivity, reduce risk exposure, and focus on their core activities, including design and client service.
enVista is the leading enterprise cost management services provider, offering expert consulting and technology services from source to consumption. enVista enables leading companies to reduce operating costs, improve customer service and enhance profitability through innovative solutions and deep domain expertise across a multitude of industries and vertical markets.
Makeover Solutions, Inc., a marketing company, provides Web-based virtual makeovers. The company builds online communities for women users interested in beauty and beauty care conversations. Its Personal Makeover helps companies to create an online relationship with their customers. The company was incorporated in 2007 and is based in New York, New York.
SpaceClaim Corporation develops and markets 3D direct modeling software solutions that help engineers, CAE analysts, product designers, and manufacturers in the product development process. It offers SpaceClaim Engineer that enables engineers to create concepts and prepare 3D designs for prototyping, analysis, and manufacturing; SpaceClaim Style, an industrial design tool that is used to create, edit, and validate design concepts; SpaceClaim Viewer, which enables its users to open and measure SpaceClaim designs, drawings, and 3D markups; and add-on modules and plug-ins for SpaceClaim software. The company also provides educational licenses for its software solutions to professors, instructors, and educational institutions in North America, as well as training programs for its software. Its products are used for conceptual engineering, CAE/model preparation, industrial design, and manufacturing engineering applications. The company offers its products through a network of resellers in the United States and internationally. SpaceClaim Corporation was founded in 2005 and is headquartered in Concord, Massachusetts with additional offices in France and Japan.
enVista is the leading enterprise cost management services provider, offering expert consulting and technology services from source to consumption. enVista enables leading companies to reduce operating costs, improve customer service and enhance profitability through innovative solutions and deep domain expertise across a multitude of industries and vertical markets.
Newforma develops and supports project information management (PIM) software tailored for the architecture, engineering, and construction (AEC) sectors. Founded in 2003 and headquartered in Manchester, New Hampshire, the company's mission is to enhance collaboration among firms, streamline project information, and integrate processes for improved project delivery. Newforma's solutions facilitate collaboration among owners, designers, builders, and extended construction teams through mobile, cloud, and desktop applications. The software is utilized to manage information on over 1.4 million projects globally, which helps clients increase productivity, reduce risk exposure, and focus on their core activities, including design and client service.
Flurry is an application that provides analytics for businesses to monitor the trends and habits of mobile users across multiple mobile applications. Flurry’s mobile analytics solution enables businesses to understand how consumers interact with their mobile applications. Over 125,000 companies use Flurry’s analytics platform in more than 400,000 applications to measure audience reach, engagement, retention, conversions, revenue, and more. The service is completely free, takes just five minutes for basic integration, and is continuously updated with the industry's advanced features. Flurry Analytics is available for iOS, Android, Windows Phone, HTML5, hybrid apps, mobile/web, Blackberry, and JavaME.
Handmark develops applications for Android, Blackberry, Palm, and Window mobile platforms. Its solutions include games, personalization solutions, and ringtones. Its applications cover areas, such as multimedia, utilities and tools, sports, business and productivity, fitness and health, news and information, reference, and entertainment.
SpaceClaim Corporation develops and markets 3D direct modeling software solutions that help engineers, CAE analysts, product designers, and manufacturers in the product development process. It offers SpaceClaim Engineer that enables engineers to create concepts and prepare 3D designs for prototyping, analysis, and manufacturing; SpaceClaim Style, an industrial design tool that is used to create, edit, and validate design concepts; SpaceClaim Viewer, which enables its users to open and measure SpaceClaim designs, drawings, and 3D markups; and add-on modules and plug-ins for SpaceClaim software. The company also provides educational licenses for its software solutions to professors, instructors, and educational institutions in North America, as well as training programs for its software. Its products are used for conceptual engineering, CAE/model preparation, industrial design, and manufacturing engineering applications. The company offers its products through a network of resellers in the United States and internationally. SpaceClaim Corporation was founded in 2005 and is headquartered in Concord, Massachusetts with additional offices in France and Japan.
GlycoFi is a biotech firm that develops biotherapeutics based on the glycan optimization technology. The firm aims to develop its own pipeline of therapeutic proteins and team with other drug-makers to develop products. GlycoFi has developed a protein manufacturing process using yeast-based glycolysation where the resulting proteins can be used in drug development. GlycoFi was incorporated in 2000 and is based in Lebanon, New Hampshire. As of June 6, 2006, GlycoFi, Inc. operates as a subsidiary of Merck & Co. Inc.
Newforma develops and supports project information management (PIM) software tailored for the architecture, engineering, and construction (AEC) sectors. Founded in 2003 and headquartered in Manchester, New Hampshire, the company's mission is to enhance collaboration among firms, streamline project information, and integrate processes for improved project delivery. Newforma's solutions facilitate collaboration among owners, designers, builders, and extended construction teams through mobile, cloud, and desktop applications. The software is utilized to manage information on over 1.4 million projects globally, which helps clients increase productivity, reduce risk exposure, and focus on their core activities, including design and client service.
Handmark develops applications for Android, Blackberry, Palm, and Window mobile platforms. Its solutions include games, personalization solutions, and ringtones. Its applications cover areas, such as multimedia, utilities and tools, sports, business and productivity, fitness and health, news and information, reference, and entertainment.
Medical Metrx Solutions, Inc. (formerly Medical Media Systems) is a medical technology and services company providing diagnostic quality 3-D virtual models of patient anatomy built from CT and MR scan data using the company’s proprietary modeling software. The company’s models — which contain more precise quantitative measurement information than competitors’ offerings — are provided to interventional radiologists and vascular surgeons who use them for pre-operative planning and post-operative surveillance of their patients’ conditions. The company was acquired by AIG Altaris Health Partners in 2005.