Principia SGR

KLISBio is a pioneering company in regenerative medicine that utilizes silk as a versatile and biocompatible scaffold material to advance tissue regeneration methods. The company focuses on various clinical applications within the orthopedic and vascular markets, developing innovative silk-based biomaterials that facilitate the regeneration of human tissues. These materials are designed to degrade safely within the body, making them suitable for medical research and treatment of tissue-related diseases. By harnessing the potential of nano-fibers, KLISBio aims to transform the landscape of medical technology and improve patient outcomes.

WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

Enterome SA is a biopharmaceutical company based in Paris, France, with an additional office in Cambridge, Massachusetts. Founded in 2008, Enterome specializes in the development of disease management solutions leveraging the gut microbiome. It focuses on creating biomarkers and therapeutics for microbiome-related diseases, including inflammatory bowel diseases and metabolic disorders. The company utilizes its proprietary OncoMimic technology to address cancer treatment by overcoming immune tolerance against tumors, enabling the development of off-the-shelf therapies that prompt a robust immune response. Enterome's innovative drug candidates, which include small proteins and peptides, aim to generate an endogenous CD8 T cell response and are currently advancing through Phase 2 clinical trials for challenging cancers such as glioblastoma and colorectal cancer. The company has formed a strategic collaboration with Takeda Pharmaceutical Company to enhance its research and development capabilities.

COMPASS Pathways is a mental health care company based in Cheshire, United Kingdom, with operations in the United States. The company is focused on developing innovative therapies for treatment-resistant depression (TRD) using its proprietary psilocybin formulation, COMP360. Currently undergoing Phase IIb clinical trials, COMP360 aims to provide a new treatment option for patients who have not responded to traditional depression therapies. COMPASS Pathways emphasizes the combination of psilocybin-assisted therapy with psychological support to enhance treatment efficacy. The company is committed to addressing the significant unmet needs in mental health care by advancing evidence-based solutions for those suffering from mental health challenges.

ComfTech s.r.l. is a company based in Monza, Italy, that specializes in the development and marketing of wearable monitoring systems using sensorized garments designed for newborns. Founded in 2010, ComfTech produces innovative monitoring solutions that enable accurate, continuous, and non-invasive measurement of various physiological parameters. The company’s smart garments are designed for ease of use, ensuring comfort for both the newborn and their families, while also meeting the needs of medical professionals. Collaborating closely with doctors and nurses, ComfTech has created products that combine advanced technology with user-friendly design, leading to positive feedback from healthcare providers and families.

CrestOptics is a company specializing in the development and manufacture of advanced systems for fluorescence microscopy. Based in Rome, Italy, it leverages the expertise of its team, which has extensive experience in scientific research, industrial design, and electrooptical systems. The company focuses on creating state-of-the-art instruments that enhance the capabilities of researchers and industries engaged in fluorescence microscopy and spectroscopy. CrestOptics is known for its commitment to innovation, working on collaborative research projects with renowned institutions, such as CNR – FISBAT, to advance technologies for live cell imaging and laser-activated experiments. By combining optical and electrooptical technology with tailored services, CrestOptics provides solutions that improve sensitivity, image quality, and clarity, meeting the evolving demands of the scientific community.

Enterome SA is a biopharmaceutical company based in Paris, France, with an additional office in Cambridge, Massachusetts. Founded in 2008, Enterome specializes in the development of disease management solutions leveraging the gut microbiome. It focuses on creating biomarkers and therapeutics for microbiome-related diseases, including inflammatory bowel diseases and metabolic disorders. The company utilizes its proprietary OncoMimic technology to address cancer treatment by overcoming immune tolerance against tumors, enabling the development of off-the-shelf therapies that prompt a robust immune response. Enterome's innovative drug candidates, which include small proteins and peptides, aim to generate an endogenous CD8 T cell response and are currently advancing through Phase 2 clinical trials for challenging cancers such as glioblastoma and colorectal cancer. The company has formed a strategic collaboration with Takeda Pharmaceutical Company to enhance its research and development capabilities.

Clinical Trial Center S.P.A. offers clinic research and trial services.

TRIFARMA S.p.A. is a manufacturer and distributor of active pharmaceutical ingredients (APIs), headquartered in Milan, Italy. Established in 1983, the company offers a diverse range of products that cater to various therapeutic areas, including anti-osteoporosis, progestogen, expectorant, anticonvulsant, glucocorticoid, antibacterial, antidepressant, anti-inflammatory, and many others. TRIFARMA emphasizes the development of APIs, particularly those related to antibiotics and drugs for the nervous system, which allows it to support the healthcare sector effectively. The company's operations facilitate a rapid transition from laboratory development to industrial scale production, ensuring timely delivery of essential pharmaceutical ingredients to its clients.

WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

Enterome SA is a biopharmaceutical company based in Paris, France, with an additional office in Cambridge, Massachusetts. Founded in 2008, Enterome specializes in the development of disease management solutions leveraging the gut microbiome. It focuses on creating biomarkers and therapeutics for microbiome-related diseases, including inflammatory bowel diseases and metabolic disorders. The company utilizes its proprietary OncoMimic technology to address cancer treatment by overcoming immune tolerance against tumors, enabling the development of off-the-shelf therapies that prompt a robust immune response. Enterome's innovative drug candidates, which include small proteins and peptides, aim to generate an endogenous CD8 T cell response and are currently advancing through Phase 2 clinical trials for challenging cancers such as glioblastoma and colorectal cancer. The company has formed a strategic collaboration with Takeda Pharmaceutical Company to enhance its research and development capabilities.

AnaBios is a contract research organization (CRO) focused on enhancing drug discovery through human-centric methodologies. The company utilizes proprietary technology that leverages human donor organs and tissues to examine ex vivo human responses to drugs, thereby deepening the understanding of human physiology's molecular and functional aspects. Its research primarily targets significant unmet medical needs, including cardiac disease, pain management, polycystic kidney disease, and neurodegeneration. By generating valuable predictive human data prior to clinical trials, AnaBios aids pharmaceutical companies, contract research organizations, and academic institutions in selecting the most effective and safest drugs, ultimately reducing the time and costs associated with clinical trial failures. Through collaborations with Fortune 500 companies, AnaBios aims to facilitate therapeutic advancements that contribute to improved patient outcomes and wellbeing.

Pedius is a communication system specifically designed to assist deaf individuals in making phone calls. The company has developed a smartphone application that allows users to engage in real-time conversations by typing or speaking messages. Once a message is sent, the recipient can respond verbally, and the app provides an immediate transcription of the response, facilitating seamless communication. This technology employs voice recognition to enhance the user's experience while ensuring privacy throughout the conversation. The Pedius app is particularly valuable for everyday interactions, such as booking appointments, making reservations, or contacting friends and family, thereby empowering deaf individuals to communicate more effectively in scenarios where phone contact is essential.

Ixaltis is a pharmaceutical company focused on developing therapeutics for genitourinary disorders that have unmet medical needs. Founded by a team of experts in urology and pharmaceuticals, including Dr. Philippe Lluel and Christian Chavy, Ixaltis aims to identify and repurpose drugs that have already reached clinical stages for use in treating genitourinary tract diseases. The company has established a proprietary position with its lead product, Litoxetine, which operates through a specific mechanism of action to address various urogenital disorders. By leveraging its expertise, Ixaltis seeks to improve urinary continence and enhance the quality of life for patients suffering from these conditions.

Rigenerand Srl is a biomedical company based in Medolla, Italy, established in 2009 by Prof. Massimo Dominici and Prof. Pierfranco Conte. It specializes in the development and production of devices that support the culture of stem cells for both pre-clinical and clinical applications. The company focuses on enhancing the ex-vivo phase of stem cell expansion by utilizing innovative biocompatible materials to achieve high cell yields. Rigenerand's product pipeline includes various reabsorbable biomaterials for tissue engineering, improved transport systems for direct stem cell delivery to patients, and 3D cell culture systems designed for drug discovery and delivery. The company's technology emerges from a collaboration between a biomedical firm and researchers from the University of Modena and Reggio Emilia.

KLISBio is a pioneering company in regenerative medicine that utilizes silk as a versatile and biocompatible scaffold material to advance tissue regeneration methods. The company focuses on various clinical applications within the orthopedic and vascular markets, developing innovative silk-based biomaterials that facilitate the regeneration of human tissues. These materials are designed to degrade safely within the body, making them suitable for medical research and treatment of tissue-related diseases. By harnessing the potential of nano-fibers, KLISBio aims to transform the landscape of medical technology and improve patient outcomes.

Comecer, formally known as Costruzioni Meccaniche Certificate, is a leading manufacturer specializing in protection technologies within the fields of nuclear medicine and isolation technology. The company designs and produces advanced screening systems and equipment tailored for large industrial groups, research organizations, hospitals, universities, and pharmaceutical companies. Comecer's innovative medical equipment focuses on the management, processing, and dispensing of radio-pharmaceuticals, addressing the needs of various sectors, including pharmaceuticals, nuclear, electronics, and food. Additionally, the company plays a crucial role in the nuclear power industry by providing equipment for the processing, decommissioning, and disposal of radioactive materials, thereby contributing to safety and regulatory compliance.

DoveConviene S.R.L. designs and develops a digital platform which helps people to shop by saving money through offers and leaflets presented georeferenced manner. The company was founded in 2010 and is based in Sestu, Italy. The startup trades under the brand DoveConviene in Italy and ShopFully in the U.S., as well as various other names in Spain, Brazil, Mexico and Indonesia (TechCrunch).

WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

Tacatì s.r.l. is an online grocery shopping platform based in Asti, Italy, established in 2012 by Giulia Valente and Stefano Cravero. The company enables customers to purchase groceries online, focusing on the delivery of local organic products to various locations, including homes and offices. Customers have the flexibility to pay for their orders either online or upon delivery.

Affaredelgiorno is a company that specializes in offering online discount coupons for a variety of food and non-food products. Founded in 2013 by Antonio Folino, the company operates from its headquarters in Italy. Affaredelgiorno aims to provide customers with savings opportunities while enhancing their shopping experience through accessible and user-friendly online platforms.

Rysto is a pioneering social platform designed specifically for the restaurant and hospitality labor market. It facilitates the connection between businesses in the catering and food service sectors and potential employees, enabling the rapid filling of temporary and permanent job vacancies. By utilizing geo-located, real-time technology, Rysto addresses common industry challenges such as employee no-shows, fluctuating demand, and seasonal staffing needs. The platform not only helps companies find qualified professionals but also offers training to enhance service quality and product offerings. Rysto aims to establish itself as the leading provider of innovative solutions in the restaurant and hospitality industries, benefiting businesses, customers, and employees alike.

Weekend-a-gogo is a company based in Naples, Italy, specializing in providing weekend packages for tourists. The organization focuses on creating enjoyable and memorable travel experiences for visitors seeking short getaways in various destinations. By curating attractive packages, Weekend-a-gogo aims to enhance the travel experience and cater to the needs of leisure travelers.

D-Share is an international company specializing in digital publishing and media. It combines technological expertise and extensive knowledge of the publishing industry to assist clients in developing innovative business models leveraging next-generation technologies. D-Share offers comprehensive, end-to-end solutions that enhance user experience and facilitate the creation and distribution of digital content. With offices in Italy and the United States, the company provides publishers and media businesses with robust software and services designed to monetize and distribute digital content effectively across various platforms, including tablets, mobile devices, and web applications.

DoveConviene S.R.L. designs and develops a digital platform which helps people to shop by saving money through offers and leaflets presented georeferenced manner. The company was founded in 2010 and is based in Sestu, Italy. The startup trades under the brand DoveConviene in Italy and ShopFully in the U.S., as well as various other names in Spain, Brazil, Mexico and Indonesia (TechCrunch).

im3D Clinic Sud specializes in developing advanced technologies for 3D screening in cancer prevention. The company focuses on creating products that employ cutting-edge Computer Aided Detection (CAD) techniques, utilizing proprietary algorithms and methodologies honed from extensive scientific, clinical, and technical research. By collaborating closely with healthcare professionals and researchers, im3D aims to identify their needs and innovate diagnostic tools that are less invasive, more flexible, reliable, and easier to use. Since its inception, the company has committed to maintaining high-quality standards and fostering continuous improvement in both its research and development processes and customer satisfaction efforts.

WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

Bangbite S.r.l. offers online soccer management games. It provides OFootball, website and mobile phone application game about management of a virtual football team. The company was founded in 2009 and is based in Sassari, Italy.

Jusp is a developer of a mobile payment platform that transforms smartphones into point of sale devices. The company offers a solution that includes a card reader, which connects to smartphones through a mini-jack lead, allowing the reading of chip cards. Their application manages the transaction process, enabling merchants to accept card payments effortlessly. By simplifying payments and transactions for both customers and businesses, Jusp aims to enhance the payment experience through a user-friendly app and minimal device interaction.

StreetLib is a publishing facilitator that serves as a global gateway to the international book market, which generates approximately $143 billion annually, with a significant portion occurring outside the United States. The company caters to both independent authors and multinational publishers, offering extensive distribution services for ebooks, audiobooks, comics, magazines, and print-on-demand paperbacks. StreetLib's platform includes features such as catalog and metadata management, digital production tools, analytics, online marketing, and royalties management, allowing publishers to maintain ownership and control over their digital supply chains. The company's standard business model involves no upfront fees, taking a 10% commission on each sale made, thus enhancing accessibility and reach for its clients across various retail, digital library, and subscription service outlets.

Itsworld Sicilia operates digital system that monitors photovoltaic facilities. The company is based in Milan, Italy.

Eco4Cloud is a developer of infrastructure management software focused on modernizing data centers and enhancing the capabilities of cloud computing. The company’s software utilizes automation policies to optimize resource utilization, significantly improving efficiency while reducing costs associated with over-provisioning. By leveraging virtualization platforms, Eco4Cloud's solution hosts applications on virtual machines that can be consolidated onto fewer physical servers. This approach allows for the deactivation or reduction of power in unutilized servers, leading to substantial energy savings. Additionally, Eco4Cloud’s technology helps prevent overload situations, ensuring a high-quality service experience for users. The automated management features further streamline the administration and monitoring processes of data centers, making it easier for cloud providers and large enterprises to enhance their IT infrastructure.

4w MarketPlace srl is a leading online advertising network in the Italian digital market, established in 2008 and headquartered in Milan. The company connects over 12,000 publishers with more than 500 prestigious websites and mobile platforms, achieving a reach of 70% and generating over 7 billion monthly impressions. It provides advertisers access to a qualified audience through a comprehensive range of advertising formats, including native ads, video, and display, tailored for desktop, tablet, and smartphone environments. Utilizing a proprietary suite that integrates advanced technologies, 4w MarketPlace manages both reserved and programmatic advertising solutions. Since 2009, it has held exclusive management of advertising spaces on websites affiliated with the Premium Publisher Network, a consortium founded by prominent media groups.

CicerOOs is an innovative company that promotes global destinations and their attractions in an engaging and entertaining manner. It operates an online search portal that delivers comprehensive travel and tourism information, making it easier for consumers to find and explore various travel locations. By analyzing content about these destinations available on the web, CicerOOs enhances the searchability and accessibility of travel-related information, providing users with an enjoyable experience while planning their trips.

Vivocha is a cloud-based online customer interaction platform that facilitates live support for businesses engaging with customers on their websites. The service enables seamless communication through various channels, including VoIP, video, chat, and audio callbacks, alongside collaboration tools such as assisted browsing and document sharing. By providing these multi-channel communication options, Vivocha helps brands enhance customer engagement and streamline the sales process, making online interactions more efficient and effective.

MoneyFarm is a financial services company that offers an online wealth management platform designed to help individuals manage their investments effectively and transparently. The platform provides personalized financial advisory services, allowing users to create investment portfolios tailored to their financial goals and risk tolerance. MoneyFarm focuses on enabling customers to monitor their investments and recommending adjustments to maintain balanced portfolios. Through its innovative approach, the company aims to grow and protect wealth in a cost-effective manner.

Eco4Cloud is a developer of infrastructure management software focused on modernizing data centers and enhancing the capabilities of cloud computing. The company’s software utilizes automation policies to optimize resource utilization, significantly improving efficiency while reducing costs associated with over-provisioning. By leveraging virtualization platforms, Eco4Cloud's solution hosts applications on virtual machines that can be consolidated onto fewer physical servers. This approach allows for the deactivation or reduction of power in unutilized servers, leading to substantial energy savings. Additionally, Eco4Cloud’s technology helps prevent overload situations, ensuring a high-quality service experience for users. The automated management features further streamline the administration and monitoring processes of data centers, making it easier for cloud providers and large enterprises to enhance their IT infrastructure.

6sicuro is a company that specializes in online insurance services, focusing on price comparison for various insurance products, including car and motorcycle insurance. It operates a digital platform that allows users to easily compare prices and options, empowering them to select and purchase the most suitable insurance policies to meet their requirements. By streamlining the process of finding and acquiring insurance, 6sicuro aims to enhance the user experience and facilitate informed decision-making in the insurance market.

Docebo Inc. is a provider of a cloud-based learning management platform designed to facilitate training for external workforces, partners, and customers across North America, Europe, and the Asia-Pacific region. Founded in 2005 and headquartered in Toronto, Canada, Docebo enables organizations to centralize and manage learning materials within a single system, enhancing the learning experience and increasing productivity. Its platform includes several key modules, such as Docebo Learn for content organization and analytics, Docebo Discover, Coach & Share for personalized and social learning, and Docebo Extended Enterprise for managing multiple audience portals. Additionally, the company offers integrations with platforms like Salesforce, as well as mobile learning solutions and AI-driven tools. Docebo's services cater to a variety of industries, including technology, media, manufacturing, financial services, and retail, with a subscription-based revenue model primarily driven by its North American customer base.

Neodata Group specializes in optimizing the delivery of digital content through a range of advanced solutions for online dealers and publishers. Founded in 2004 and headquartered in Milan, Italy, with additional offices in Catania and Los Angeles, the company offers ad-serving technologies that include advanced display ads, video ad-server capabilities, mobile applications, and real-time reporting tools. Its News Publishers Solutions feature a homepage layout support system and personalized news delivery. Additionally, Neodata provides innovative recommendation tools, such as the Articles Recommendation System, which utilizes proprietary algorithms for real-time article suggestions based on semantic similarity, and Neo-TM, a text-mining engine that assesses content similarity across large text documents. The company is committed to helping clients engage their audiences effectively by leveraging audience knowledge and delivering actionable insights.

Applix, founded in 2010, specializes in mobile solutions aimed at helping brands, publishers, and institutions establish a digital presence. The company focuses on two main areas: Digital Publishing and Mobile & Apps. In Digital Publishing, Applix transforms traditional paper-based publications into interactive digital experiences accessible on smartphones, tablets, and computers, while also providing tools to monitor reader engagement. In the Mobile & Apps segment, Applix develops customized solutions tailored to the specific needs of clients, leveraging its technological expertise and innovative capabilities. The company has expanded its offerings through strategic acquisitions, including Xorovo and bSmart, which enhance its mobile device solutions and digital publishing services for education. With a strong international presence, Applix's applications have been downloaded in over 120 countries and have received multiple awards, achieving top rankings in app stores worldwide.

Gada Group is a distributor of medical technology devices and equipment, serving both public and private health sectors. The company specializes in the distribution, marketing, and promotion of various medical devices and systems, including those for cardiovascular care, blood management, and infusion management. Additionally, Gada Group offers intensive care systems and integrated healthcare services, aimed at enhancing operational efficiency and cost effectiveness for healthcare partners and hospitals. Through its comprehensive approach, Gada Group supports the healthcare industry in delivering improved patient care.

Citynews is an Italian-based network of local newspaper sites, currently operating in nine cities with plans to expand to 30 major Italian cities. The company runs an online platform that delivers daily news stories, issues, and information specifically tailored to various Italian provinces. With an average monthly traffic of 1.4 million visits, Citynews provides accessible editions that can be viewed on any device, allowing readers and local communities to engage, inform, and share knowledge effectively.

X2TV is owned by Beeweeb and participated by Quantica Sgr – Venture Capital through the Principia II fund. Beeweeb is a privately-owned company that has designed and developed Mobile and web 2.0 solutions for over 10 years. X2TV board of directors is composed by Giampiero Recco (Chairman), Enrico Donati (Chief Executive Officer) and Stefano Peroncini (Quantica SGR). The board of statutory auditors is composed by Giovanni Pinna Parpaglia (President) Andrea Bonelli and Marco Gramegna. X2TV’s first partner to launch an “augmented” TV broadcast in Italy was RAI with Voyager, hosted by Roberto Giacobbo at dinner time. Incorporated in November 2010, X2TV Srl is dedicated to the digital entertainment service X2TV; it was born as a spinoff of Beeweeb S.p.A. with the goal of developing and managing the service given in partnership with TV broadcasters. The Headquarters is located in Roma, via Giacomo Peroni 400/402. X2TV department is located in Sardinia Technology Park.

Altilia is a prominent intelligent automation software company that focuses on democratizing AI to assist enterprises in automating document-intensive processes. The company offers a no-code, software-as-a-service platform designed for users of varying technical backgrounds to easily convert knowledge into algorithms for document processing. Utilizing advanced machine learning capabilities, Altilia's platform enables businesses to handle a broad spectrum of documents, from simple forms like invoices to more complex unstructured documents such as financial statements and annual reports, with human-like precision. The platform provides custom automation solutions across diverse industries, including banking, insurance, utilities, retail, and securities, addressing a wide range of applications such as data extraction, fraud detection, and customer profiling. Recently recognized by Gartner as a representative provider in the document processing market, Altilia is transitioning towards a bundled, ready-to-use solution approach, moving away from traditional bespoke projects.

Kee Square S.r.l., based in Milano, Italy, specializes in the design and development of advanced techniques for video and audio signal processing. The company focuses on biometric identification and tracking, as well as the detection of hazardous events and security applications. Its product lineup includes Morpheus AC, which provides physical access protection through facial analysis; Morpheus PC, aimed at securing logical access to workstations via video camera facial recognition; Morpheus SDK, a software development kit for building and comparing biometric templates; and Morpheus ICAO, which evaluates facial images to ensure compliance with specific requirements. Kee Square caters primarily to law enforcement and commercial markets, offering tailored solutions to meet their unique security needs.

Correlec engages in searching, extracting, updating, and classifying data originating from various sources and grouping it into logical categories. The company is headquartered in Legnano, Italy.

Dialectica is a biotechnological company that produces neuronal cellular models. The company was founded in 2004 and is based in Milan, Italy.