Principia SGR

KLISBio is a company focused on advancing regenerative medicine by utilizing silk as a versatile and biocompatible scaffold material. The company develops innovative medical technologies aimed at improving tissue regeneration methods, specifically targeting clinical applications in orthopaedics and vascular health. Its silk-based biomaterials are designed to regenerate human tissues, including those in the vascular system, and are engineered to degrade and be safely absorbed by the body. This approach enables medical research entities to harness the benefits of nano-fibers for the treatment of various tissue-related diseases.

WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

Enterome SA is a biopharmaceutical company based in Paris, France, with an additional office in Cambridge, Massachusetts. Founded in 2008, the company specializes in developing innovative disease management solutions that leverage the understanding of the gut microbiome. Enterome focuses on creating biomarkers, companion diagnostics, and therapeutics targeted at microbiome-related diseases, including inflammatory bowel diseases and metabolic disorders. The company’s OncoMimic technology addresses cancer by mimicking tumor-associated antigens, thereby inducing a strong immune response against solid tumors. Enterome's drug candidates are designed to modulate the immune system and are currently advancing through clinical trials, with several programs in Phase 2 targeting challenging cancers such as glioblastoma, adrenal malignancies, and colorectal cancer. The company has formed a strategic collaboration with Takeda Pharmaceutical Company to enhance its research and development efforts.

COMPASS Pathways is a mental health care company based in Cheshire, United Kingdom, with operations in the United States. The company is focused on developing innovative therapies for treatment-resistant depression (TRD) using its proprietary psilocybin formulation, COMP360. Currently undergoing Phase IIb clinical trials, COMP360 aims to provide a new treatment option for patients who have not responded to traditional depression therapies. COMPASS Pathways emphasizes the combination of psilocybin-assisted therapy with psychological support to enhance treatment efficacy. The company is committed to addressing the significant unmet needs in mental health care by advancing evidence-based solutions for those suffering from mental health challenges.

ComfTech s.r.l. is a company based in Monza, Italy, that specializes in developing and marketing wearable monitoring systems for newborns. Founded in 2010, ComfTech designs sensorized garments that facilitate continuous, non-invasive monitoring of various physiological parameters. These smart garments are easy to dress and use, ensuring comfort for both the newborn and their caregivers. The products are developed in close collaboration with medical professionals, resulting in solutions that prioritize technological advancement while remaining user-friendly. ComfTech's innovative approach has garnered positive feedback from healthcare providers and families, highlighting the effectiveness and practicality of its monitoring systems in the neonatal care market.

CrestOptics is a company specializing in the development and manufacture of advanced systems for fluorescence microscopy. Based in Rome, Italy, the firm leverages its proximity to renowned research institutions to foster collaboration on innovative projects, including partnerships with organizations like CNR – FISBAT. CrestOptics focuses on creating high-performance microscopy instruments that utilize optical and electrooptical technology, enhancing sensitivity, image quality, and clarity for both scientific and industrial applications. The company also benefits from the expertise of its partner, Crisel Instruments, which has over 15 years of experience in live cell imaging systems. Through its commitment to research and development, CrestOptics aims to provide state-of-the-art solutions tailored to the needs of the research community and various industrial sectors.

Enterome SA is a biopharmaceutical company based in Paris, France, with an additional office in Cambridge, Massachusetts. Founded in 2008, the company specializes in developing innovative disease management solutions that leverage the understanding of the gut microbiome. Enterome focuses on creating biomarkers, companion diagnostics, and therapeutics targeted at microbiome-related diseases, including inflammatory bowel diseases and metabolic disorders. The company’s OncoMimic technology addresses cancer by mimicking tumor-associated antigens, thereby inducing a strong immune response against solid tumors. Enterome's drug candidates are designed to modulate the immune system and are currently advancing through clinical trials, with several programs in Phase 2 targeting challenging cancers such as glioblastoma, adrenal malignancies, and colorectal cancer. The company has formed a strategic collaboration with Takeda Pharmaceutical Company to enhance its research and development efforts.

Clinical Trial Center S.P.A. offers clinic research and trial services.

TRIFARMA S.p.A. is a manufacturer and distributor of active pharmaceutical ingredients (APIs), headquartered in Milan, Italy. Established in 1983, the company offers a diverse range of products that cater to various therapeutic areas, including anti-osteoporosis, progestogen, expectorant, anticonvulsant, glucocorticoid, antibacterial, antidepressant, anti-inflammatory, and many others. TRIFARMA emphasizes the development of APIs, particularly those related to antibiotics and drugs for the nervous system, which allows it to support the healthcare sector effectively. The company's operations facilitate a rapid transition from laboratory development to industrial scale production, ensuring timely delivery of essential pharmaceutical ingredients to its clients.

WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

Enterome SA is a biopharmaceutical company based in Paris, France, with an additional office in Cambridge, Massachusetts. Founded in 2008, the company specializes in developing innovative disease management solutions that leverage the understanding of the gut microbiome. Enterome focuses on creating biomarkers, companion diagnostics, and therapeutics targeted at microbiome-related diseases, including inflammatory bowel diseases and metabolic disorders. The company’s OncoMimic technology addresses cancer by mimicking tumor-associated antigens, thereby inducing a strong immune response against solid tumors. Enterome's drug candidates are designed to modulate the immune system and are currently advancing through clinical trials, with several programs in Phase 2 targeting challenging cancers such as glioblastoma, adrenal malignancies, and colorectal cancer. The company has formed a strategic collaboration with Takeda Pharmaceutical Company to enhance its research and development efforts.

AnaBios is a contract research organization (CRO) focused on enhancing drug discovery through human-centric methodologies. The company utilizes proprietary technology that leverages human donor organs and tissues to examine ex vivo human responses to drugs, thereby deepening the understanding of human physiology's molecular and functional aspects. Its research primarily targets significant unmet medical needs, including cardiac disease, pain management, polycystic kidney disease, and neurodegeneration. By generating valuable predictive human data prior to clinical trials, AnaBios aids pharmaceutical companies, contract research organizations, and academic institutions in selecting the most effective and safest drugs, ultimately reducing the time and costs associated with clinical trial failures. Through collaborations with Fortune 500 companies, AnaBios aims to facilitate therapeutic advancements that contribute to improved patient outcomes and wellbeing.

Pedius is a communication platform designed to assist deaf individuals in making phone calls with ease. By utilizing voice recognition technology, the system transcribes spoken responses in real-time, allowing users to engage in conversations with hearing individuals through a smartphone app. Users can initiate calls by typing or speaking messages, receiving immediate transcriptions of the responses on the other end. This service is particularly valuable for making essential calls, such as scheduling appointments or contacting family and friends, especially when reaching individuals accessible only by phone. Pedius not only facilitates effective communication but also prioritizes user privacy throughout the process.

Ixaltis is a pharmaceutical company focused on developing therapeutics for genitourinary disorders that have unmet medical needs. Founded by a team of experts in urology and pharmaceuticals, the company aims to create innovative treatments by repurposing drugs that have already reached clinical stages for use in urogenital conditions. Ixaltis has established a proprietary position with Litoxetine, a drug leveraging its unique mechanism of action to address urogenital and other disorders. The company's goal is to enhance patient outcomes, particularly in improving urinary continence, through its novel pharmaceutical products.

Rigenerand Srl is a biomedical company based in Medolla, Italy, established in 2009 by Prof. Massimo Dominici and Prof. Pierfranco Conte. It specializes in the development and production of devices that support the culture of stem cells for both pre-clinical and clinical applications. The company focuses on enhancing the ex-vivo phase of stem cell expansion by utilizing innovative biocompatible materials to achieve high cell yields. Rigenerand's product pipeline includes various reabsorbable biomaterials for tissue engineering, improved transport systems for direct stem cell delivery to patients, and 3D cell culture systems designed for drug discovery and delivery. The company's technology emerges from a collaboration between a biomedical firm and researchers from the University of Modena and Reggio Emilia.

KLISBio is a company focused on advancing regenerative medicine by utilizing silk as a versatile and biocompatible scaffold material. The company develops innovative medical technologies aimed at improving tissue regeneration methods, specifically targeting clinical applications in orthopaedics and vascular health. Its silk-based biomaterials are designed to regenerate human tissues, including those in the vascular system, and are engineered to degrade and be safely absorbed by the body. This approach enables medical research entities to harness the benefits of nano-fibers for the treatment of various tissue-related diseases.

Comecer, formally known as Costruzioni Meccaniche Certificate, is a leading manufacturer specializing in protection technologies within the fields of nuclear medicine and isolation technology. The company designs and produces advanced screening systems and equipment tailored for large industrial groups, research organizations, hospitals, universities, and pharmaceutical companies. Comecer's innovative medical equipment focuses on the management, processing, and dispensing of radio-pharmaceuticals, addressing the needs of various sectors, including pharmaceuticals, nuclear, electronics, and food. Additionally, the company plays a crucial role in the nuclear power industry by providing equipment for the processing, decommissioning, and disposal of radioactive materials, thereby contributing to safety and regulatory compliance.

DoveConviene S.R.L. designs and develops a digital platform which helps people to shop by saving money through offers and leaflets presented georeferenced manner. The company was founded in 2010 and is based in Sestu, Italy. The startup trades under the brand DoveConviene in Italy and ShopFully in the U.S., as well as various other names in Spain, Brazil, Mexico and Indonesia (TechCrunch).

WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

Tacatì s.r.l. is an online grocery shopping platform based in Asti, Italy, established in 2012 by Giulia Valente and Stefano Cravero. The company enables customers to purchase groceries online, focusing on the delivery of local organic products to various locations, including homes and offices. Customers have the flexibility to pay for their orders either online or upon delivery.

Affaredelgiorno is a company that specializes in offering online discount coupons for a variety of food and non-food products. Founded in 2013 by Antonio Folino, the company operates from its headquarters in Italy. Affaredelgiorno aims to provide customers with savings opportunities while enhancing their shopping experience through accessible and user-friendly online platforms.

Rysto is a pioneering social platform designed for the restaurant and hospitality labor market, facilitating the connection between businesses and potential employees. It enables companies in the catering and food service sectors to efficiently fill both temporary and permanent job vacancies through a geo-located, real-time system. This approach addresses challenges such as employee no-shows and fluctuating demand due to seasonality. In addition to job placements, Rysto's platform also focuses on identifying and training qualified professionals, enhancing the overall quality of service and product offerings within the industry. The company's vision is to establish itself as a leading provider of innovative solutions for the restaurant and hospitality sectors, benefiting businesses, customers, and employees alike.

Weekend-a-gogo is a company based in Naples, Italy, specializing in offering weekend packages designed for tourists. The business focuses on creating memorable travel experiences by curating a range of activities and accommodations that cater to diverse interests. Through its packages, Weekend-a-gogo aims to enhance the weekend getaway experience for visitors, allowing them to explore and enjoy the local culture and attractions.

D-Share is an international company specializing in digital publishing and media. It offers a range of software and services designed to create and distribute digital content effectively. By leveraging advanced technologies and extensive expertise in the publishing industry, D-Share provides end-to-end solutions that help publishers and media businesses monetize and distribute their content. The company focuses on user experience development and equips clients with tools for editing and managing next-generation content across various platforms, including tablets, mobile devices, and web applications. With offices in Italy and the United States, D-Share is committed to exploring innovative business models for its clients in the evolving digital landscape.

DoveConviene S.R.L. designs and develops a digital platform which helps people to shop by saving money through offers and leaflets presented georeferenced manner. The company was founded in 2010 and is based in Sestu, Italy. The startup trades under the brand DoveConviene in Italy and ShopFully in the U.S., as well as various other names in Spain, Brazil, Mexico and Indonesia (TechCrunch).

im3D Clinic Sud specializes in developing advanced technologies for 3D screening in cancer prevention. The company focuses on creating products that employ cutting-edge Computer Aided Detection (CAD) techniques, utilizing proprietary algorithms and methodologies honed from extensive scientific, clinical, and technical research. By collaborating closely with healthcare professionals and researchers, im3D aims to identify their needs and innovate diagnostic tools that are less invasive, more flexible, reliable, and easier to use. Since its inception, the company has committed to maintaining high-quality standards and fostering continuous improvement in both its research and development processes and customer satisfaction efforts.

WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

Bangbite S.r.l. offers online soccer management games. It provides OFootball, website and mobile phone application game about management of a virtual football team. The company was founded in 2009 and is based in Sassari, Italy.

Jusp is a mobile payment platform that transforms smartphones into point-of-sale devices, allowing merchants to accept card payments with ease. The company provides a card reader that connects through a mini-jack to any smart device, enabling the reading of card chips. Through its application, Jusp manages the transaction process, simplifying payments for both customers and businesses. This innovation reduces the complexity of payment transactions, making it easier for users to complete purchases with just a few taps on their devices.

StreetLib is a publishing facilitator that serves as a gateway to the global book market, which is valued at $143 billion, with a significant portion occurring outside the United States. Catering to both independent authors and large publishers, StreetLib provides extensive distribution for ebooks, audiobooks, comics, magazines, and print-on-demand paperbacks through a wide network of retail, digital library, and subscription service outlets. The platform offers various services, including catalog and metadata management, digital production tools, analytics, online marketing, and royalties management, allowing publishers to maintain control over their digital supply chains. StreetLib operates on a model with no upfront fees, taking a 10% commission on each sale, thereby facilitating access to international markets for publishers of all sizes.

Itsworld Sicilia operates digital system that monitors photovoltaic facilities. The company is based in Milan, Italy.

Eco4Cloud specializes in modernizing data centers through its infrastructure management software, which enhances efficiency and service quality while achieving significant energy savings. The company utilizes virtualization platforms, such as VMware vSphere and Microsoft Hyper-V, to host applications on virtual machines (VMs) allocated to physical servers. By consolidating VMs onto fewer servers, Eco4Cloud allows for the powering down of excess servers or switching them to low power states, thereby reducing electrical energy consumption. The software also implements automation policies that optimize resource utilization, preventing over-provisioning and associated costs. Additionally, Eco4Cloud's solution mitigates the risk of overload situations, ensuring consistent service quality for users. Automated management further alleviates the administrative and monitoring burdens typically associated with data center operations, making it an attractive option for cloud providers and large enterprises aiming to optimize their IT infrastructure.

4w MarketPlace srl is a leading online advertising network in the Italian digital market, established in 2008 and headquartered in Milan. The company connects over 12,000 publishers with more than 500 prestigious websites and mobile platforms, achieving a reach of 70% and generating over 7 billion monthly impressions. It provides advertisers access to a qualified audience through a comprehensive range of advertising formats, including native ads, video, and display, tailored for desktop, tablet, and smartphone environments. Utilizing a proprietary suite that integrates advanced technologies, 4w MarketPlace manages both reserved and programmatic advertising solutions. Since 2009, it has held exclusive management of advertising spaces on websites affiliated with the Premium Publisher Network, a consortium founded by prominent media groups.

CicerOOs is an online platform that focuses on promoting travel destinations and their attractions worldwide through engaging and humorous content. The company provides a searchable portal that offers travel and tourism information, analyzing various online resources to make this content accessible to consumers. By combining entertainment with informative travel insights, CicerOOs aims to enhance the travel planning experience and encourage exploration of diverse locations.

Vivocha is a cloud-based platform that facilitates live support for online customers, allowing businesses to engage with prospects and clients directly on their websites. The service offers a variety of multi-channel communication options, including VoIP for audio and video interactions, chat, audio callbacks, and collaboration tools such as assisted browsing and document sharing. By providing these features, Vivocha enables companies to enhance customer interactions, ultimately aiming to increase sales and improve overall customer satisfaction.

MoneyFarm is a financial services company that offers an online wealth management platform designed to help individuals manage their investments effectively and transparently. The platform provides personalized financial advisory services, allowing users to create investment portfolios tailored to their financial goals and risk tolerance. MoneyFarm focuses on enabling customers to monitor their investments and recommending adjustments to maintain balanced portfolios. Through its innovative approach, the company aims to grow and protect wealth in a cost-effective manner.

Eco4Cloud specializes in modernizing data centers through its infrastructure management software, which enhances efficiency and service quality while achieving significant energy savings. The company utilizes virtualization platforms, such as VMware vSphere and Microsoft Hyper-V, to host applications on virtual machines (VMs) allocated to physical servers. By consolidating VMs onto fewer servers, Eco4Cloud allows for the powering down of excess servers or switching them to low power states, thereby reducing electrical energy consumption. The software also implements automation policies that optimize resource utilization, preventing over-provisioning and associated costs. Additionally, Eco4Cloud's solution mitigates the risk of overload situations, ensuring consistent service quality for users. Automated management further alleviates the administrative and monitoring burdens typically associated with data center operations, making it an attractive option for cloud providers and large enterprises aiming to optimize their IT infrastructure.

6sicuro is an online insurance service provider that specializes in comparing prices for various insurance products, including car and motorcycle insurance. The company has developed a digital platform that allows users to easily assess and compare different insurance options, helping them select and purchase the most suitable coverage to meet their needs. In addition to insurance, 6sicuro also offers tools for comparing mortgage prices, further enhancing its range of financial services.

Docebo Inc. is a provider of a cloud-based learning management platform designed to facilitate training for external workforces, partners, and customers across North America, Europe, and the Asia-Pacific region. Founded in 2005 and headquartered in Toronto, Canada, Docebo enables organizations to centralize and manage learning materials within a single system, enhancing the learning experience and increasing productivity. Its platform includes several key modules, such as Docebo Learn for content organization and analytics, Docebo Discover, Coach & Share for personalized and social learning, and Docebo Extended Enterprise for managing multiple audience portals. Additionally, the company offers integrations with platforms like Salesforce, as well as mobile learning solutions and AI-driven tools. Docebo's services cater to a variety of industries, including technology, media, manufacturing, financial services, and retail, with a subscription-based revenue model primarily driven by its North American customer base.

Neodata Group specializes in optimizing the delivery of digital content through a range of advanced solutions for online dealers and publishers. Founded in 2004 and headquartered in Milan, Italy, with additional offices in Catania and Los Angeles, the company offers ad-serving technologies that include advanced display ads, video ad-server capabilities, mobile applications, and real-time reporting tools. Its News Publishers Solutions feature a homepage layout support system and personalized news delivery. Additionally, Neodata provides innovative recommendation tools, such as the Articles Recommendation System, which utilizes proprietary algorithms for real-time article suggestions based on semantic similarity, and Neo-TM, a text-mining engine that assesses content similarity across large text documents. The company is committed to helping clients engage their audiences effectively by leveraging audience knowledge and delivering actionable insights.

Applix, founded in 2010, specializes in mobile solutions aimed at helping brands, publishers, and institutions establish a digital presence. The company focuses on two main areas: Digital Publishing and Mobile & Apps. In Digital Publishing, Applix transforms traditional paper-based publications into interactive digital experiences accessible on smartphones, tablets, and computers, while also providing tools to monitor reader engagement. In the Mobile & Apps segment, Applix develops customized solutions tailored to the specific needs of clients, leveraging its technological expertise and innovative capabilities. The company has expanded its offerings through strategic acquisitions, including Xorovo and bSmart, which enhance its mobile device solutions and digital publishing services for education. With a strong international presence, Applix's applications have been downloaded in over 120 countries and have received multiple awards, achieving top rankings in app stores worldwide.

Gada Group is a distributor of medical technology devices and equipment, serving both public and private health sectors. The company specializes in the distribution, marketing, and promotion of various medical devices and systems, including those for cardiovascular care, blood management, and infusion management. Additionally, Gada Group offers intensive care systems and integrated healthcare services, aimed at enhancing operational efficiency and cost effectiveness for healthcare partners and hospitals. Through its comprehensive approach, Gada Group supports the healthcare industry in delivering improved patient care.

Citynews is an Italian network of local newspaper websites that currently operates in nine cities and aims to expand to the thirty largest cities in Italy. The platform serves as a comprehensive source of news and information, producing daily stories that are accessible online from any device. With an audience of approximately 1.4 million visits each month, Citynews facilitates the exchange of knowledge and information among readers and local communities, fostering engagement and communication within these regions.

X2TV is owned by Beeweeb and participated by Quantica Sgr – Venture Capital through the Principia II fund. Beeweeb is a privately-owned company that has designed and developed Mobile and web 2.0 solutions for over 10 years. X2TV board of directors is composed by Giampiero Recco (Chairman), Enrico Donati (Chief Executive Officer) and Stefano Peroncini (Quantica SGR). The board of statutory auditors is composed by Giovanni Pinna Parpaglia (President) Andrea Bonelli and Marco Gramegna. X2TV’s first partner to launch an “augmented” TV broadcast in Italy was RAI with Voyager, hosted by Roberto Giacobbo at dinner time. Incorporated in November 2010, X2TV Srl is dedicated to the digital entertainment service X2TV; it was born as a spinoff of Beeweeb S.p.A. with the goal of developing and managing the service given in partnership with TV broadcasters. The Headquarters is located in Roma, via Giacomo Peroni 400/402. X2TV department is located in Sardinia Technology Park.

Altilia is an intelligent automation software company focused on democratizing artificial intelligence for enterprises, particularly in automating document-intensive processes. The company offers a no-code, SaaS-based platform that allows users of varying technical backgrounds to convert knowledge into algorithms for document processing. This platform utilizes advanced machine learning techniques to enable businesses to efficiently handle both simple, structured documents like invoices and complex, unstructured documents such as financial statements. Altilia's solutions cater to various industries, including banking, insurance, utilities, and retail, addressing a range of applications such as fraud detection, customer profiling, and risk assessment. Recently recognized by Gartner, Altilia is transitioning towards a marketplace model that provides bundled, ready-to-use solutions, thereby streamlining the implementation process and reducing traditional project costs and timelines.

Kee Square S.r.l., based in Milano, Italy, specializes in the design and development of advanced techniques for video and audio signal processing. The company focuses on biometric identification and tracking, as well as the detection of hazardous events and security applications. Its product lineup includes Morpheus AC, which provides physical access protection through facial analysis; Morpheus PC, aimed at securing logical access to workstations via video camera facial recognition; Morpheus SDK, a software development kit for building and comparing biometric templates; and Morpheus ICAO, which evaluates facial images to ensure compliance with specific requirements. Kee Square caters primarily to law enforcement and commercial markets, offering tailored solutions to meet their unique security needs.

Correlec engages in searching, extracting, updating, and classifying data originating from various sources and grouping it into logical categories. The company is headquartered in Legnano, Italy.

Dialectica is a biotechnological company that produces neuronal cellular models. The company was founded in 2004 and is based in Milan, Italy.