Commons Capital

Founded in 2001, Commons Capital is a venture capital firm based in Brookline, Massachusetts. It focuses on investing in early-stage companies operating in clean energy, environment, education, and healthcare sectors.

William Osborn

Investment Manager

13 past transactions

HistoRx

Venture Round in 2011
HistoRx is developing theranostic solutions to towards individualized patient care. HistoRx's proprietary technology delivers objective and reproducible multiparametric analysis of proteins in tissue, providing insights into cancer treatment.

Combinent Biomedical Systems

Venture Round in 2009
Combinent Biomedical Systems, Inc. is a women's healthcare company based in Lexington, Massachusetts, that specializes in the development of multi-segmented vaginal rings. These innovative devices facilitate the transvaginal delivery of a variety of therapeutic agents, including hydrophobic and hydrophilic molecules, proteins, and other large molecules. The company's primary focus is on addressing women's reproductive endocrinology disorders, while also targeting conditions such as diabetes, obesity, and infectious diseases. Established in 2000, Combinent Biomedical Systems aims to enhance drug delivery methods specifically tailored for women's health needs.

Claros Diagnostics

Series B in 2009
Claros Diagnostics Inc., established in 2015, specializes in developing portable immunoassay systems designed for point-of-care blood testing. Their innovative product comprises a handheld analyzer and disposable cassettes capable of detecting multiple biomarkers simultaneously. This technology enables healthcare professionals and patients to conduct tests for infectious diseases, cancer, and immune disorders outside traditional laboratory settings.

CodeRyte

Series D in 2008
CodeRyte is a leading provider of computer-assisted coding and clinical data extraction solutions tailored for the healthcare industry. The company offers advanced software products, including CodeAssist, which automates the coding process by integrating with user operational information systems, and CodeComplete, an outsourced coding solution. Additionally, CodeRyte's DataScout tool analyzes physician narratives to extract clinically relevant information from both free-text and structured medical records. By streamlining coding processes and improving data extraction, CodeRyte enables healthcare providers to secure appropriate reimbursements, enhance compliance, and make informed treatment and business decisions. Its solutions are utilized by many prominent physician practices, billing companies, and academic medical centers across the nation, positioning CodeRyte as a vital component of their coding and data-mining operations.

HistoRx

Series B in 2007
HistoRx is developing theranostic solutions to towards individualized patient care. HistoRx's proprietary technology delivers objective and reproducible multiparametric analysis of proteins in tissue, providing insights into cancer treatment.

Combinent Biomedical Systems

Series A in 2007
Combinent Biomedical Systems, Inc. is a women's healthcare company based in Lexington, Massachusetts, that specializes in the development of multi-segmented vaginal rings. These innovative devices facilitate the transvaginal delivery of a variety of therapeutic agents, including hydrophobic and hydrophilic molecules, proteins, and other large molecules. The company's primary focus is on addressing women's reproductive endocrinology disorders, while also targeting conditions such as diabetes, obesity, and infectious diseases. Established in 2000, Combinent Biomedical Systems aims to enhance drug delivery methods specifically tailored for women's health needs.

Claros Diagnostics

Series A in 2007
Claros Diagnostics Inc., established in 2015, specializes in developing portable immunoassay systems designed for point-of-care blood testing. Their innovative product comprises a handheld analyzer and disposable cassettes capable of detecting multiple biomarkers simultaneously. This technology enables healthcare professionals and patients to conduct tests for infectious diseases, cancer, and immune disorders outside traditional laboratory settings.

Passport Systems

Series B in 2006
Passport Systems Inc. is a company that designs and develops advanced inspection and detection systems aimed at addressing security threats, particularly in the wake of the 9/11 terrorist attacks. Based in Billerica, Massachusetts, and founded in 2002, the company specializes in creating both active and passive solutions for the automatic detection, localization, and identification of concealed threats and contraband. Its notable products include the SmartScan 3D, which is utilized for the automated clearing of cargo while detecting potential threats, and the SmartShield, a networked radiation detection system aimed at monitoring and preventing radiological threats. The technology developed by Passport Systems is implemented in various critical areas such as airports, seaports, and border crossings, enhancing national and international security by facilitating the identification of explosives, contraband, and other hazardous materials. Through its innovative solutions, Passport Systems plays a significant role in improving safety and security at key points in the supply chain industry.

CodeRyte

Series C in 2006
CodeRyte is a leading provider of computer-assisted coding and clinical data extraction solutions tailored for the healthcare industry. The company offers advanced software products, including CodeAssist, which automates the coding process by integrating with user operational information systems, and CodeComplete, an outsourced coding solution. Additionally, CodeRyte's DataScout tool analyzes physician narratives to extract clinically relevant information from both free-text and structured medical records. By streamlining coding processes and improving data extraction, CodeRyte enables healthcare providers to secure appropriate reimbursements, enhance compliance, and make informed treatment and business decisions. Its solutions are utilized by many prominent physician practices, billing companies, and academic medical centers across the nation, positioning CodeRyte as a vital component of their coding and data-mining operations.

Protonex Technology

Series B in 2005
Protonex Technology is a developer and manufacturer of intelligent power management and portable fuel cell products tailored for military and commercial markets. The company focuses on revolutionizing portable power solutions, offering advantages over traditional batteries and generators. By providing mission-critical equipment, Protonex enhances energy efficiency and operational flexibility for military applications, addressing the evolving power needs of its users.

Protonex Technology

Series A in 2004
Protonex Technology is a developer and manufacturer of intelligent power management and portable fuel cell products tailored for military and commercial markets. The company focuses on revolutionizing portable power solutions, offering advantages over traditional batteries and generators. By providing mission-critical equipment, Protonex enhances energy efficiency and operational flexibility for military applications, addressing the evolving power needs of its users.

Medical Metrx Solutions

Series B in 2003
Medical Metrx Solutions, Inc. (formerly Medical Media Systems) is a medical technology and services company providing diagnostic quality 3-D virtual models of patient anatomy built from CT and MR scan data using the company’s proprietary modeling software. The company’s models — which contain more precise quantitative measurement information than competitors’ offerings — are provided to interventional radiologists and vascular surgeons who use them for pre-operative planning and post-operative surveillance of their patients’ conditions. The company was acquired by AIG Altaris Health Partners in 2005.

H2Gen Innovations

Series A in 2001
H2Gen Innovations, Inc., of Alexandria , Virginia develops, manufactures and markets on-site hydrogen appliances that provide a significant breakthrough for the existing industrial hydrogen market and will be a key enabling technology for the emerging hydrogen economy. The H2Gen hydrogen generator module (HGM) converts natural gas to hydrogen using a unique steam methane reformer, producing 2,000 scf/hr. of up to “five nines” pure hydrogen. The all-in cost of hydrogen produced with the HGM at the point of delivery is 35% to 65% less than existing conventional methods of producing and delivering hydrogen to target end-use customers. They believe that they have the superior technology for on-site hydrogen production in regard to output, purity and price for a remarkably small appliance. The company was formed in February 2001 by a team of engineers who saw the market opportunity, and who had been working on the concept and technology for the preceding seven years.
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