Deerfield

Ray Therapeutics is a company focused on developing innovative optogenetic gene therapies aimed at treating patients with blinding diseases. By creating technology that enhances the understanding of rare retinal conditions, the company strives to empower healthcare professionals to effectively diagnose, cure, and manage inherited retinal diseases. Through its commitment to advancing optogenetics, Ray Therapeutics seeks to improve the quality of life for those affected by these debilitating conditions.

Vicinitas Therapeutics is a biotech startup that specializes in developing medicines that impact patient lives. Its vision is to use its proprietary Deubiquitinase Targeting Chimera (DUBTAC) platform to restore the levels of aberrantly degraded proteins that cause disease to confer therapeutic benefit.

MMI S.r.l manufactures and develops micro instruments to support surgical interventions at a dimensional scale. The company develops wristed micro instruments and their fabrication process. The company also develops and offers robotic platform. The company's proprietary robotic platform and wristed micro instruments simplifies reconstruction procedures after traumatic injuries and after tumor removal in breast, head, and bones. The company was founded in 2015 and is headquartered in Calci, Italy.

Insilico Medicine, Inc. is an artificial intelligence company based in Rockville, Maryland, specializing in drug discovery, biomarker development, and aging research. Founded in 2014, the company leverages advanced AI techniques, including generative adversarial networks and deep learning, to create novel molecular structures for various diseases. Insilico Medicine has developed a comprehensive end-to-end pipeline for drug discovery, which encompasses all stages from initial research to clinical trials. Its notable platforms include Pharma.AI, which offers machine learning services to various sectors, and Young.AI, which integrates predictors of age. The company is actively engaged in internal drug discovery programs targeting conditions such as cancer, Alzheimer's disease, and diabetes. Additionally, Insilico Medicine has partnered with Life Extension to produce nutraceutical products using bioinformatics and deep learning. It serves a diverse clientele, including academia, pharmaceutical companies, and cosmetic firms, while also providing consumer-facing applications to enhance health and longevity.

Epic Sciences, Inc. is a diagnostics company based in San Diego, California, that specializes in developing sensitive tests for identifying and molecularly characterizing circulating tumor cells (CTCs) from minimally invasive blood samples. The company utilizes a platform that profiles single-cell phenotype and genotype, offering insights into phenotypic measures, specific biomarker expression levels, subcellular biomarker localization, and morphologic characteristics. Additionally, Epic Sciences provides the Oncotype DX AR-V7 Nucleus Detect test for patients with metastatic castration-resistant prostate cancer and offers solutions for biopharmaceutical companies. The company collaborates with various biotechnology and pharmaceutical firms, as well as major cancer centers and research institutions, to enhance cancer management and guide personalized medicine. Founded in 2008, Epic Sciences is dedicated to improving access to real-time biopsy material for better patient outcomes.

Acutus Medical, Inc. is an arrhythmia management company that specializes in developing medical technologies for diagnosing and treating complex cardiac arrhythmias. Founded in 2011 and based in Carlsbad, California, the company designs, manufactures, and markets a comprehensive range of tools for catheter-based ablation procedures. Its product offerings include advanced imaging and mapping systems, such as the AcQMap console and workstation, along with diagnostic catheters and therapeutic devices like ablation catheters and robotic navigation systems. Acutus Medical's innovative platform enables electrophysiologists to visualize the heart's activation patterns, facilitating more effective treatment of arrhythmias. The company collaborates with medical scientists and engineers in the U.S. and Europe to enhance its product development and provides solutions to hospitals and electrophysiologists globally.

Valneva SE is a biotechnology company focused on developing and commercializing vaccines for infectious diseases that lack effective solutions. It offers two commercial vaccines for travelers: IXIARO/JESPECT, which prevents Japanese encephalitis, and DUKORAL, aimed at preventing cholera and certain types of diarrhea. The company is also advancing a pipeline of vaccines, including a candidate targeting Lyme disease and a single-shot vaccine for chikungunya. Valneva operates in several countries, including Austria, Canada, France, Sweden, the United Kingdom, and the United States. Established in 1999 and headquartered in Nantes, France, Valneva collaborates with Dynavax Technologies Corporation to enhance vaccine development efforts, particularly in response to COVID-19.

Based in Seattle, Boston and Tokyo, Aurion Biotech is a clinical-stage biotech company. Our mission is to cure leading forms of blindness and transform the lives of millions of patients, by developing a platform of advanced therapies to treat ocular diseases. Our first candidate is for the treatment of corneal edema, and one of the first clinically validated cell therapies for corneal care. Healthy cells from a donor cornea are cultured in a novel, multi-step, proprietary and patented process. Cells from a single donor can be used to treat more than 100 recipient eyes. In clinical trials in Japan, patients have experienced significant and durable improvements in key measures of corneal health: visual acuity, corneal endothelial cell density and corneal thickness.

Vibliome Therapeutics, Inc. is a biotechnology company based in Bozeman, Montana, focused on innovative therapeutic developments. The company has created a systematic approach to develop small molecule kinase inhibitors, which exhibit unique and, in some cases, extraordinary selectivity profiles. With over 500 kinases in the human genome that regulate essential cellular functions, Vibliome's chemistry platform provides significant opportunities for variation while adhering to a consistent architectural framework. In addition to their work on kinase inhibitors for cancer treatment, Vibliome is also advancing a non-hormonal birth control pill for men, leveraging the potential of homeodomain-interacting protein kinase 4 (HIPK4). Since its incorporation in 2017, the company has aimed to address critical health challenges through its innovative research and development efforts.

Somatus is a healthcare company that partners with health plans, health systems, and nephrology, and primary care groups. It provides integrated care for patients with or at risk of developing kidney disease. Somatus' is vertically integrated clinical services and technology delay or prevent disease progression, improve quality and care coordination, and increase the use of home dialysis modalities and rates of kidney transplantation. The company is headquartered in McLean, Virginia, and founded by a team of world-class healthcare operators, successful entrepreneurs, and leading clinicians treating kidney disease.

ConcertoCare provides healthcare services primarily to dual-eligible patients enrolled in Medicare and Medicaid, as well as those with complex medical needs. The company focuses on addressing critical vulnerabilities faced by these patients and health plans by offering personalized primary care, chronic condition management, and support for transitions between various care settings. Additionally, ConcertoCare delivers medical, social, and logistical assistance to enhance patient outcomes. Founded in 2004 and based in Aliso Viejo, California, the company operates care centers in locations including Renton, Washington, and several cities in Michigan. The name Concerto reflects its holistic approach to healthcare, emphasizing collaboration among patients, providers, and health plans to ensure coordinated care that respects the dignity and health of each individual.

Hyperfine Research Inc. specializes in developing portable magnetic resonance imaging (MRI) scanners, aimed at making medical imaging more accessible. Founded in 2014 and based in Guilford, Connecticut, the company focuses on general anatomical brain imaging and addresses various medical conditions, including headaches, strokes, non-specific muscle weakness, encephalopathy, spinal cord compressions, diabetic foot disease, and musculoskeletal trauma. Within a year of its establishment, Hyperfine successfully produced its first images, and it has since improved the quality and functionality of its imaging technology. The company’s mission is to democratize healthcare by ensuring that medical imaging is available to people worldwide.

Lark Technologies, Inc. develops a chronic disease prevention and management platform. It offers Lark, a digital platform that provides personalized coaching to help people manage and prevent chronic diseases, such as for diabetes, prediabetes, and hypertension. The company’s application also provides user activity, sleep, and nutrition data. It serves employers and health plans. Lark Technologies, Inc. was founded in 2010 and is based in Mountain View, California.

DeepSight™ Technology is revolutionizing diagnostic medical imaging by taking the safest, fastest, most affordable, and most accessible imaging modality and delivering a quantum leap in performance

BioAtla, Inc. is a clinical-stage biopharmaceutical company based in San Diego, California, focused on developing specific and selective antibody-based therapeutics for various cancers. The company's lead product candidate, BA3011, is a conditionally active biologic (CAB) antibody-drug conjugate aimed at treating soft tissue and bone sarcomas, non-small cell lung cancer, and other tumor types. Additionally, BioAtla is developing BA3021, a CAB ADC targeted at non-small cell lung cancer and melanoma, as well as BA3071, which is an anti-cytotoxic T-lymphocyte-associated antigen 4 antibody for various cancers including renal cell carcinoma and bladder cancer. Utilizing proprietary platforms for antibody discovery and optimization, BioAtla aims to create safer and more effective cancer treatments by enhancing selectivity for tumor tissues while minimizing effects on normal tissues. The company holds over 150 issued patents and applications related to its innovative therapeutic approaches, which have the potential to address previously untreatable cancers.

ARS Pharmaceuticals is a stealth pharmaceutical company that developed a novel intranasal epinephrine spray with a unique absorption technology that could be easy-to-use, convenient, and more reliable for patients and loved ones at risk of severe allergic reactions to food, medications and insect bites that could lead to life-threatening anaphylaxis.

PepGen is a clinical-stage biotechnology company based in Oxford, United Kingdom, focused on advancing the delivery of nucleic acid therapeutics, particularly antisense oligonucleotides. Established in 2018, PepGen aims to enhance the clinical efficacy of these therapeutics through its proprietary Enhanced Delivery Oligonucleotide (EDO) platform. This innovative technology employs engineered peptides designed for optimized tissue penetration, cellular uptake, and nuclear delivery, enabling effective transport of oligonucleotides to various target tissues, including smooth, skeletal, and cardiac muscle, as well as the central nervous system. By leveraging its drug delivery capabilities, PepGen seeks to transform the treatment landscape for severe neuromuscular and neurological diseases.

Strata Oncology is a precision oncology company dedicated to transforming cancer care by expanding patient access to precision medicine clinical trials and accelerating drug approval. Strata's national precision oncology platform serves the needs of patients, providers and drug developers by providing a link from patient screening to streamlined enrollment in mutation-matched clinical trials. Follow us on Twitter @StrataOncology.

Sema4 is a patient-centered predictive health company dedicated to advancing the diagnosis, treatment, and prevention of disease. With their innovative Sema4 Health Intelligence Platform, they’re using advanced network analysis to build better models of human health and deliver personalized insights for patients.

Frontier Medicines Corporation is a pre-clinical stage biopharmaceutical company based in South San Francisco, California, founded in 2018. The company specializes in discovering and developing medicines that target cancer-causing proteins through its innovative chemoproteomics platform. This platform utilizes advanced computational techniques and machine learning to identify new binding pockets on proteins, thereby facilitating the discovery and development of small-molecule drugs. By enhancing the drug development process, Frontier Medicines aims to deliver breakthrough therapies that can significantly change the treatment landscape for debilitating diseases.

Talkspace Network LLC is an online therapy provider that offers mental health care through text, audio, and video messaging. Founded in 2012 and based in New York, the company connects users with licensed therapists, allowing for confidential therapy without the need for appointments. Its services include unlimited messaging therapy, therapy for teens and couples, as well as specialized options for businesses and social media support. The platform aims to make mental health care more accessible and affordable, helping individuals who may find traditional face-to-face therapy challenging or financially burdensome. By leveraging technology, Talkspace provides a convenient alternative that enables users to communicate with therapists in a comfortable manner, facilitating the pursuit of mental well-being.

Adela is focused on the detection of cancer and other high-morbidity, high-mortality conditions through a routine blood test.

Synthekine Inc. is a biotechnology company focused on developing innovative cytokine therapies and immunotherapies for cancer and autoimmune disorders. Founded in 2018 and based in Menlo Park, California, the company leverages advanced platform technologies, including engineered partial agonists and orthogonal cell therapies, to create targeted treatments. Synthekine's notable innovations include the Synthekine Platform, which utilizes surrogate agonists instead of traditional mutant cytokines. The company's product pipeline features STK-009, an orthogonal ligand paired with SYNCAR-001, an engineered CAR-T therapy targeting CD-19, as well as STK-012, a partial agonist of IL-2. Synthekine's approach emphasizes safety and efficacy, utilizing immunological insights to guide the development of therapeutics that selectively modulate immune system pathways. Preclinical studies have indicated promising efficacy and tolerability for its lead programs, positioning Synthekine as a key player in the biotechnology landscape.

CareMax is a technology-enabled care platform providing value-based care and chronic disease management to seniors. CarMax operates medical centers that offer a comprehensive suite of healthcare and social services, and a proprietary software and services platform that provides data, analytics, and rules-based decision tools/workflows for physicians across the United States.

Larimar Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing treatments for complex rare diseases. The company’s lead compound, CTI-1601, is currently being evaluated in a Phase 1 clinical program as a potential treatment for Friedreich’s ataxia, a rare and progressive genetic disease. Larimar also plans to use its intracellular delivery platform to design other fusion proteins to target additional rare diseases characterized by deficiencies in intracellular bioactive compounds.

ADC Therapeutics is a clinical-stage oncology drug discovery and development company focused on advancing highly potent and targeted antibody drug conjugates (ADCs) for the treatment of hematological cancers and solid tumors. Our ADCs are developed using the latest-generation pyrrolobenzodiazepine (PBD) dimer technology providing a superior therapeutic index compared to first- generation PBD ADCs in preclinical studies. PBD dimers are very potent toxins that actively kill cancer cells and have a differentiated mechanism of action than warheads commonly used in other ADCs.

Adaptive Phage Therapeutics, Inc. specializes in developing therapeutic solutions to combat the increasing threat of multi-drug resistant (MDR) bacteria. Founded in 2016 and based in Gaithersburg, Maryland, the company utilizes a unique resource known as PhageBank, which is an extensive and dynamic collection of bacteriophages—viruses that specifically target and attack harmful bacteria. Through a rapid system that matches these phages to individual patient bacterial infections, Adaptive Phage Therapeutics aims to enhance treatment options for patients suffering from MDR infections. Their innovative approach enables medical researchers to create tailored therapies that effectively detect and eliminate resistant bacterial strains.

Nuvalent is a biotechnology company that develops targeted therapies for clinically proven kinase targets in cancer. Leveraging deep expertise in structure-based design, Nuvalent develops innovative small molecules with exquisite target selectivity to overcome resistance, minimize adverse events, and drive more durable responses. It is advancing a robust pipeline with parallel lead programs in ROS1-positive and ALK-positive NSCLC, along with multiple discovery-stage research programs. It was founded in 2017 and is based in Cambridge, Massachusetts.

Cohere Health, Inc., founded in 2019 and headquartered in Boston, Massachusetts, develops a software platform aimed at enhancing collaboration among healthcare stakeholders. The company focuses on improving the patient journey by creating a user-friendly experience for patients, healthcare providers, and health plans. Its mission includes increasing the quality of care, reducing overall healthcare costs, and fostering transparency throughout the patient care process. By leveraging technology, Cohere Health seeks to address the complexities of healthcare delivery, ultimately benefiting all parties involved.

Jaguar Gene Therapy is accelerating breakthroughs in gene therapy for patients suffering from severe genetic diseases.

Vesta Healthcare is an industry-leading technology and clinical services organization, dedicated to connecting caregiver insights to the rest of the care team. Vesta Healthcare proactively identifies the need for additional resources in the home and provides 24/7 telehealth support for caregivers and care recipients, with a focus on high-need, frail senior populations. Vesta partners with home care agencies, health plans and providers to create value-based population health programs that emphasize clinical quality, improved health outcomes and personalized engagement. Vesta Healthcare is headquartered in New York, NY.

Crossover Health, Inc. specializes in workplace healthcare services aimed at enhancing the health and well-being of employees. Founded in 2010 and headquartered in Aliso Viejo, California, the company operates health centers across the United States, including Silicon Valley. Crossover Health provides a comprehensive range of services, including primary and urgent care, preventive care, chronic disease management, and various ancillary services such as physical therapy and health coaching. By focusing on customized health solutions based on health analytics, Crossover Health collaborates with employers to optimize benefit design and enhance employee engagement in their health. This approach aims to transform traditional healthcare models by reducing costs and improving care quality, ultimately fostering a healthier, more motivated workforce.

Happify is a behavior change technology company that drives personal, business, and healthcare outcomes through improved emotional health. It features science-based activities and games that tackle topics such as resilience and mindfulness, as well as conditions ranging from depression and anxiety to chronic pain and insomnia.

Xeris Biopharma is a specialty pharmaceutical company focused on developing and commercializing ready-to-use injectable and infusible drug formulations. Utilizing its proprietary XeriSol and XeriJect technology platforms, the company delivers highly concentrated, non-aqueous formulations of peptides, proteins, and small molecules via subcutaneous and intramuscular routes. These formulations can be administered using standard delivery devices such as syringes, auto-injectors, and infusion pumps. Xeris Biopharma's lead product is Gvoke HypoPen, designed for treating severe hypoglycemia in diabetes patients. Other product candidates include a ready-to-use glucagon formulation and a diazepam formulation in clinical trials for conditions such as post-bariatric hypoglycemia and Dravet syndrome, respectively. The company aims to enhance patient care by simplifying the administration process and improving product stability, thereby reducing healthcare costs. Founded in 2005 and headquartered in Chicago, Illinois, Xeris Biopharma serves patients, caregivers, and healthcare practitioners.

Jaguar Gene Therapy is accelerating breakthroughs in gene therapy for patients suffering from severe genetic diseases.

Xilio Therapeutics is a biotechnology company advancing next-generation cancer immunotherapies designed to improve patient outcomes by unleashing the power of the immune system selectively at the site of the tumor. The company’s tumor-selective immunotherapies are based on its proprietary technology, which maximizes the potency of proven immuno-oncology therapies and restricts their activity to the tumor to minimize peripheral side effects. The broad applicability of these therapies across cancer types means that all patients could benefit from these potentially curative medicines. These tumor-selective therapies are designed to overcome the significant toxicities associated with validated IO therapies, such as IL-2 and aCTLA4, which have historically limited the number of patients that can be treated and prevented patients from completing full courses of treatment Xilio Therapeutics proprietary technology enables the explosion of therapeutic activity specifically within the tumor while reducing toxicity throughout the body a nod to the company name, Xilio, derived from the Latin term, Ex Nihilo, meaning creation or big-bang. The company applying its technology to build a broad pipeline of engineered antibodies, cytokines and chemokines as potential new options for people living with cancer. Xilio Therapeutics was founded in 2016 and is headquartered in Waltham, Massachusetts, United States.

Pairwise, Inc. is a food and technology company focused on improving the quality of fruits and vegetables through innovative agricultural gene editing techniques. Founded in 2017 and based in San Diego, California, Pairwise collaborates with food and agriculture companies to develop new crop varieties, including leafy greens, berries, and stone fruits. The company utilizes advanced tools and traits licensed from Harvard and Massachusetts General Hospital, leveraging expertise from a team with backgrounds in agriculture, consumer packaged goods, and research. With a commitment to fostering a healthier world, Pairwise aims to introduce its first products in the coming years, contributing to advancements in food technology and sustainable agriculture.

Spectrawave, Inc. is a medical device company based in Waltham, Massachusetts, founded in 2017. The company specializes in developing and manufacturing optical diagnostic and therapeutic devices aimed at enhancing the diagnosis and treatment of cardiovascular diseases. One of its key innovations is a spectroscopy catheter that integrates advanced imaging technologies to improve outcomes for patients with coronary artery disease (CAD). This cutting-edge imaging system provides interventional cardiologists with crucial optical and computational insights, enabling them to identify patients and plaque formations that may pose risks for future coronary complications. Through its focus on photonics, Spectrawave aims to optimize stent interventions and improve overall patient care in the field of cardiovascular medicine.

Nuvalent is a biotechnology company that develops targeted therapies for clinically proven kinase targets in cancer. Leveraging deep expertise in structure-based design, Nuvalent develops innovative small molecules with exquisite target selectivity to overcome resistance, minimize adverse events, and drive more durable responses. It is advancing a robust pipeline with parallel lead programs in ROS1-positive and ALK-positive NSCLC, along with multiple discovery-stage research programs. It was founded in 2017 and is based in Cambridge, Massachusetts.

MIVI Neuroscience, Inc. is a medical device company based in Eden Prairie, Minnesota, that specializes in developing and commercializing innovative solutions for neurointerventional procedures. Founded in 2013, the company offers a range of products designed to enhance patient outcomes, including high flow tubing, diagnostic catheters, guide catheters, distal access catheters, and aspiration pumps. MIVI's offerings also feature embolic protection and clot retrieval devices, along with advanced catheter systems aimed at removing obstructions and restoring blood flow for patients suffering from ischemic stroke. By focusing on reducing complications and procedure times, MIVI Neuroscience seeks to expand treatment options for a broader patient population.

Werewolf Therapeutics, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative receptor agonists for cancer immunotherapy. Established in 2017, the company is advancing a pipeline of transformative biotherapeutics aimed at treating cancer. Werewolf Therapeutics creates medicines intended for systemic delivery that remain inactive within the body until they arrive at the tumor microenvironment. At this point, the treatments activate to stimulate a robust immune response, thereby targeting and attacking cancer cells effectively.

Terns Pharmaceuticals, Inc. is a biopharmaceutical company focused on discovering and developing molecularly targeted, oral small-molecule drugs aimed at treating cancer and liver diseases. Founded in 2017 and headquartered in Foster City, California, with additional offices in Shanghai, China, Terns leverages its expertise in disease biology and medicinal chemistry to advance its drug pipeline. Notable products include TERN-101, a potent farnesoid X receptor agonist, and TERN-201, a semicarbazide-sensitive amine oxidase inhibitor. The company emphasizes a capital-efficient drug discovery model and has extensive clinical development capabilities in China, striving to bring innovative therapeutic candidates to address significant unmet medical needs both locally and globally.

FogPharma is a healthcare company founded in 2015 and headquartered in Gloucester, Massachusetts. The firm is dedicated to the pharmaceutical sector, with a primary focus on developing innovative treatments for cancer. It operates with the support of a diverse group of private and institutional investors, fostering collaboration among its founders, employees, and advisors. FogPharma aims to create a new class of medicines designed to extend and enhance the lives of cancer patients. The company's commitment to its mission drives its efforts to pioneer effective solutions in cancer treatment.

Neomorph, Inc., a biotechnology company, develops a protein degradation solution focusing on molecular glue degraders. Its targeted protein degradation drugs work by repurposing the cellular machinery to destroy proteins linked to disease. The company was founded in 2020 and is based in San Diego, California.

Encodia, Inc. engages in proteomics research and creates scalable and parallelized approaches to protein analysis. The company was founded in 2015 and is based in San Diego, California.

Cystetic Medicines develops a treatment that potentially could help people with cystic fibrosis (CF), regardless of genetic mutation.

Octave Bioscience is an early-stage molecular diagnostics company focused on neurodegenerative diseases and conditions. The company was co-founded by Melinda Thomas and William Hagstrom in 2013. Octave Bioscience is headquartered in Menlo Park, California, United States.

Springtide Child Development, Inc. provides child development services. It offers personalized and holistic treatment plans. The company provides Applied behavior analysis therapy for autism, speech therapy, occupational therapy, physical therapy, language acquisition, social skills, school readiness, and functional living skill development services. Springtide Child Development, Inc. was incorporated in 2018 and is based in Trumbull, Connecticut.

Bridge Medicines LLC offers drug discovery services. It focuses on developing technologies in academic institutions from human proof-of-concept to clinical development. The company develops inhibitors of ENL-YEATS for the treatment of acute leukemias, such as acute myelogenous leukemia and a series of orally active small molecule inhibitors of activated factor XII for the treatment of hereditary angioedema and other inflammatory disorders. Bridge Medicines LLC was founded in 2016 and is based in New York, New York.

InCarda Therapeutics, Inc., a clinical-stage biopharmaceutical company, develops transformative therapies for cardiovascular diseases that enable patients to use in the first moments of acute cardiovascular symptoms. The company develops an inhaled therapy intended to treat paroxysmal atrial fibrillation. InCarda Therapeutics, Inc. was formerly known as Pleiades Cardio-Therapeutics, Inc. and changed its name to InCarda Therapeutics, Inc. in May 2011. The company was founded in 2009 and is based in Newark, California.

Curation Health, LLC offers a clinical decision support platform designed to facilitate the transition from fee-for-service to value-based care. Founded in 2018 and based in Annapolis, Maryland, the company provides a point-of-care solution that integrates with electronic health records to deliver actionable risk adjustment insights. This platform captures accurate clinical data before and after patient visits, ensuring comprehensive provider documentation. Curation Health's services enhance performance for various healthcare programs, including Medicare Advantage, MSSP, Medicaid risk programs, and quality initiatives based on standard measures. By leveraging clinical and quality rules, the platform aims to improve documentation processes and the overall value of patient care.

Olema Oncology is a clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of therapies for women's cancers, particularly focusing on estrogen receptor-positive breast cancer. The company's lead candidate, OP-1250, is an estrogen receptor antagonist and selective degrader, currently undergoing Phase 1/2 clinical trials for the treatment of metastatic or locally advanced, estrogen receptor-positive, and human epidermal growth factor receptor 2-negative breast cancer. Olema Oncology aims to innovate targeted therapies by leveraging its expertise in endocrine-driven cancers and mechanisms of acquired resistance. The company seeks to enhance treatment options for both pre- and post-menopausal women with breast cancer, striving to transform the standard of care with more effective and convenient therapies. Founded in 2006 and headquartered in San Francisco, California, Olema was previously known as CombiThera, Inc. and rebranded in 2009.

V-Wave Ltd. is a medical technology company based in Caesarea, Israel, with additional offices in the United States. Founded in 2009, it specializes in the development of percutaneous implantable therapeutic devices aimed at treating chronic heart failure (HF) patients, which is a major cause of morbidity and mortality worldwide. The company has created the V-Wave Shunt, a biocompatible inter-atrial unidirectional implant designed for patients with both preserved and reduced ejection fractions, addressing the needs of those who experience disabling symptoms despite optimal medical therapy. V-Wave's innovative approach focuses on relieving symptoms, reducing hospitalizations, enhancing exercise capacity, and improving overall quality of life for HF patients. The organization is backed by a team of experienced engineers and medical scientists who have a proven track record in developing and bringing various implantable cardiovascular devices to market.

Ready Responders was founded in 2016 with the mission of giving patients direct access to healthcare professionals in their homes and giving Responders the opportunity to provide care in their communities. Responders travel to patients’ homes to address their physical, mental, and social health needs, utilizing technology to connect with an advanced medical or behavioral health provider, and connecting them with external resources and relationships for ongoing, sustained support. With Ready Responders, patients now have access to quality whole-person care in their homes, 16 hours a day, 365 days a year, and talented individuals are provided the opportunity to work with a rapidly growing, mission-driven company. They are in-network with most major insurance companies in the markets they serve. Ready Responders is backed by leading venture capital firms, including Google Ventures, Founders Fund, Rise of the Rest, and City Lights Capital.

Reprieve Cardiovascular, Inc., a medical device company, develops and manufactures a medical fluid management device for congestive heart failure. It offers Reprieve technology, a fluid management therapy solution providing clinicians with the ability to precisely control a patient’s fluid volume for acute decompensated heart failure (ADHF) patients. The company was founded in 2018 and is based in Milford, Massachusetts. Reprieve Cardiovascular, Inc. operates as a subsidiary of CardioRenal Systems, Inc.

Sema4 is a patient-centered predictive health company dedicated to advancing the diagnosis, treatment, and prevention of disease. With their innovative Sema4 Health Intelligence Platform, they’re using advanced network analysis to build better models of human health and deliver personalized insights for patients.

Liquid Wire is dedicated to merging electronics into the physical world through a range of dynamically stretchable and flexible circuits. Its proprietary liquid metal circuits conform naturally to any flexible surface with best-in-class pliability to ensure comfort and durability. The company was founded in 2016 and headquartered in Beaverton, Oregon. ​

QMES, LLC is a privately held company specializing in the distribution of medical equipment and supplies. It serves hospitals, rehabilitation centers, skilled nursing facilities, and home patients across Pennsylvania, New Jersey, New York, Maryland, and Delaware. Founded in 2012 and based in Phoenixville, Pennsylvania, QMES provides a diverse range of products, including those for sleep and respiratory therapy, mobility aids, wound care, non-invasive ventilation, and nutritional support. Additionally, the company offers services such as respiratory therapy, wound care, nursing, and dietary consultations. To enhance customer convenience, QMES also provides online bill payment services, allowing users to manage and pay for their medical equipment expenses. The company is committed to addressing the unique challenges faced by patients, healthcare providers, and facilities during the transition from hospital to home care.

Annexon, Inc., a clinical-stage biopharmaceutical company, discovers and develops therapeutics for autoimmune and neurodegenerative diseases. It focuses on the treatment of body, brain, and eye disorders. The company’s C1q is an initiating molecule of the classical complement pathway that targets distinct disease processes, such as antibody-mediated autoimmune disease and complement-mediated neurodegeneration. Its product candidates include ANX005, which has completed Phase 1b clinical trials to treat patients with guillain- barré syndrome; and ANX007, which has completed Phase 1b clinical trials to treat patients with glaucoma. The company’s candidates also comprise ANX005 that has completed preclinical trials to treat patients with warm autoimmune hemolytic anemia, Huntington's disease, and amyotrophic lateral sclerosis; ANX007, which has completed preclinical trials for the treatment of geographic atrophy; and ANX009 that has completed preclinical trials for the treatment of systemic autoimmune diseases. The company was founded in 2011 and is headquartered in South San Francisco, California.

Somatus is a healthcare company that partners with health plans, health systems, and nephrology, and primary care groups. It provides integrated care for patients with or at risk of developing kidney disease. Somatus' is vertically integrated clinical services and technology delay or prevent disease progression, improve quality and care coordination, and increase the use of home dialysis modalities and rates of kidney transplantation. The company is headquartered in McLean, Virginia, and founded by a team of world-class healthcare operators, successful entrepreneurs, and leading clinicians treating kidney disease.

Meditrina, Inc., founded in 2016 and based in San Jose, California, specializes in developing innovative medical devices for tissue removal solutions related to intrauterine pathology. The company provides the Aveta system, designed for healthcare professionals to facilitate hysteroscopic diagnostic and therapeutic procedures, including the removal of polyps and fibroids. In addition to its tissue removal products, Meditrina is also focused on creating fully disposable endoscopes and a comprehensive visualization system intended for use in both office and clinical settings, catering to various medical procedures.

ARTMS Products Inc. is a Vancouver-based company that specializes in manufacturing diagnostic imaging systems for the production and separation of medical isotopes. Founded in 2013, the company has developed the QUANTM Irradiation System, which facilitates decentralized and local production of critical isotopes such as gallium-68, zirconium-89, technetium-99m, and copper-64. ARTMS's primary offering, QUANTM99, is a system that combines hardware and consumables for the effective production of technetium-99m using medical cyclotrons. This innovative approach aims to enhance the accessibility and cost-effectiveness of medical isotopes, improving diagnostic imaging services.

ADC Therapeutics is a clinical-stage oncology drug discovery and development company focused on advancing highly potent and targeted antibody drug conjugates (ADCs) for the treatment of hematological cancers and solid tumors. Our ADCs are developed using the latest-generation pyrrolobenzodiazepine (PBD) dimer technology providing a superior therapeutic index compared to first- generation PBD ADCs in preclinical studies. PBD dimers are very potent toxins that actively kill cancer cells and have a differentiated mechanism of action than warheads commonly used in other ADCs.

Intersect ENT, Inc., a drug delivery company, researches and develops products for the treatment of patients with ear, nose, and throat conditions in the United States. The company offers PROPEL and PROPEL mini drug releasing implants for patients undergoing sinus surgery to treat chronic sinusitis; and PROPEL Contour, a steroid releasing implant to frontal and maxillary sinus ostia, or openings, of the dependent sinuses. It also provides SINUVA, a steroid releasing implant for refractory disease for the treatment of patients in the physician office setting. The company was formerly known as Sinexus, Inc. and changed its name to Intersect ENT, Inc. in November 2009. Intersect ENT, Inc. was founded in 2003 and is headquartered in Menlo Park, California.

CorVent Medical is developing smart, versatile, lifesaving ventilators for critical care. The company's first product, the CorVent™ Single-Use Ventilator, was designed in partnership with Design Catapult, an industrial design firm recognized for their rapid ideation of medical and commercial products. The ventilator is currently pending Emergency Use Authorization (EUA) issued by the U.S. Food and Drug Administration (FDA) for ventilators, tubing connectors and accessories, which authorizes its use for the duration of the U.S. Health and Human Services COVID-19 public health emergency declaration.

LetsGetChecked is an at-home health testing platform that connects customers to regulated laboratory testing to better manage and control one's individual health. LetsGetChecked is making healthcare and diagnostics open and patient-led, empowering people to use technology in a simple yet powerful way. This offers consumers greater control over their individual health. LetsGetChecked is headquartered in New York, NY, with tests covering general wellness, sexual health, women's health and men's health, and is available nationwide, as well as in Canada and Europe.

Ready Responders was founded in 2016 with the mission of giving patients direct access to healthcare professionals in their homes and giving Responders the opportunity to provide care in their communities. Responders travel to patients’ homes to address their physical, mental, and social health needs, utilizing technology to connect with an advanced medical or behavioral health provider, and connecting them with external resources and relationships for ongoing, sustained support. With Ready Responders, patients now have access to quality whole-person care in their homes, 16 hours a day, 365 days a year, and talented individuals are provided the opportunity to work with a rapidly growing, mission-driven company. They are in-network with most major insurance companies in the markets they serve. Ready Responders is backed by leading venture capital firms, including Google Ventures, Founders Fund, Rise of the Rest, and City Lights Capital.

RubiconMD, Inc. is a New York-based company that provides an online platform designed to facilitate communication between primary care clinicians and specialists through its eConsult service. This platform enables primary care providers to discuss cases with top specialists, thereby improving patient care and reducing costs. In addition to eConsults, RubiconMD offers a range of services, including a continuing medical education (CME) credit program, live and on-demand CME webinars, and RubiconRx, a clinical pharmacy platform that supports medication access for patients. The company also provides integration services for electronic health records, onboarding and implementation support, and clinician engagement. Founded in 2013, RubiconMD serves a diverse clientele that includes employers, community health centers, correctional health clinicians, health plans, health systems, and direct primary care practices.

Element Science is a medical device and digital health company that develops solutions at the intersection of clinical-grade wearable devices, machine learning algorithms, and lifesaving therapies to address the needs of high-risk cardiovascular patients, primarily as they transition from the hospital to home. The company developing a proprietary next-generation wearable digital platform that unites patient-centric human factor engineering, sophisticated machine learning algorithm development principles, and rigorous electromechanical medical device development standards. The company was founded in 2011 and is headquartered in San Francisco, California.

Farapulse, Inc. develops and commercializes catheter-based tools specifically designed for the treatment of atrial fibrillation. Founded in 2012 and based in Menlo Park, California, the company offers an innovative product known as FARAWAVE, which utilizes advanced tissue-selective pulsed field ablation (PFA) therapy. This therapy is available on both catheter and surgical platforms for endocardial and epicardial applications. Farapulse's product range includes various catheter types, such as over-the-wire, deflectable, linear, and circumferential lesion catheters, which enable doctors to isolate pulmonary veins safely and effectively. The company's mission is to enhance the safety, speed, accessibility, and affordability of atrial fibrillation ablation for patients worldwide.

Vesta Healthcare is an industry-leading technology and clinical services organization, dedicated to connecting caregiver insights to the rest of the care team. Vesta Healthcare proactively identifies the need for additional resources in the home and provides 24/7 telehealth support for caregivers and care recipients, with a focus on high-need, frail senior populations. Vesta partners with home care agencies, health plans and providers to create value-based population health programs that emphasize clinical quality, improved health outcomes and personalized engagement. Vesta Healthcare is headquartered in New York, NY.

Generation Bio is a genetic medicines company based in Cambridge, Massachusetts, that specializes in developing gene therapies aimed at treating both rare and prevalent diseases. Established in 2016, the company focuses on conditions affecting the liver, retina, skeletal muscle, central nervous system, and oncology. Generation Bio employs an innovative non-viral platform that includes a proprietary high-capacity DNA construct known as closed-ended DNA (ceDNA), a cell-targeted lipid nanoparticle delivery system (ctLNP), and a scalable, capsid-free manufacturing process. This approach allows for the targeted delivery of genetic materials, including large and multiple genes across various tissues, and enables redosable treatments tailored to individual patient needs. By enhancing access to therapies for rare diseases and addressing more common conditions, Generation Bio aims to provide durable and sustainable treatment options for patients throughout their lives.

Neomorph, Inc., a biotechnology company, develops a protein degradation solution focusing on molecular glue degraders. Its targeted protein degradation drugs work by repurposing the cellular machinery to destroy proteins linked to disease. The company was founded in 2020 and is based in San Diego, California.

Four Points Innovation supports Duke R&D projects throughout preclinical stages of drug discovery and development. Beginning approximately in March 2020, Duke researchers can submit proposals on projects for consideration by a Four Points Innovation committee comprised of scientific leadership representing Duke and Deerfield.

Black Diamond Therapeutics is a precision oncology medicine company focused on discovering and developing small molecule, tumor-agnostic therapies. The company's lead product candidate, BDTX-189, is designed to inhibit specific mutations in ErbB kinases, including the epidermal growth factor receptor. Additionally, Black Diamond is advancing a pipeline of allosteric-EGFR mutation inhibitors and other early-stage programs targeting allosteric mutations in kinases associated with cancer and rare genetic diseases. The company employs a technology platform known as Mutation-Allostery-Pharmacology, which aims to address undrugged mutations in patients with genetically defined cancers. Founded in 2014 and based in Cambridge, Massachusetts, Black Diamond Therapeutics was previously known as ASET Therapeutics until its rebranding in 2018.

Civetta Therapeutics, LLC develops small molecule therapeutics by targeting propeller proteins for the treatment of cancers and other diseases. The company was incorporated in 2018 and is based in Cambridge, Massachusetts.

Contessa is a Nashville-based company that specializes in Home Recovery Care, a model that provides hospital-level care to patients in their homes. Founded in 2015, Contessa aims to improve patient outcomes while reducing costs for health systems and health plans. The company's proprietary health informatics platform supports its services, which include home hospitalization programs and bundled payment managed services. ContessaCare enables healthcare providers to administer inpatient care without the need for hospital admission, enhancing the patient experience. Additionally, the company offers ContradoClaim, a claims analytics solution that facilitates prospective payment administration. Through its innovative approach, Contessa is leading the way in transforming care delivery in the healthcare sector.

Edgewise Therapeutics is a clinical-stage biopharmaceutical company based in Boulder, Colorado, specializing in the development of small molecule therapies for severe musculoskeletal diseases. Founded in 2017, the company leverages its expertise in skeletal muscle physiology to create innovative treatments for genetically defined muscle disorders, including Duchenne, Becker, and limb girdle muscular dystrophies. Edgewise Therapeutics employs a precision medicine platform to identify and target key muscle proteins and modulators, aiming to address the underlying causes of these conditions. Additionally, the company has established a state-of-the-art research facility to enhance its capabilities in understanding muscle adaptation and injury related to disease.

Nkarta, Inc., a biopharmaceutical company, develops and commercializes cell therapies for cancer treatment. The company’s approach for cellular immunotherapy involves chimeric antigen receptors on the surface of a natural killer (NK) cell that enable the cell to recognize specific proteins or antigens that are present on the surface of tumor cells. Its co-lead product candidates are NKX101, a pre-clinical product that enhances the power of innate NK biology to detect and kill cancerous cells; and NKX019, a pre-clinical product, which is based on the ability to treat various B cell malignancies by targeting the CD19 antigen found on these types of cancerous cells. The company was founded in 2015 and is headquartered in South San Francisco, California.

Frequency Therapeutics is a clinical-stage biotechnology company based in Woburn, Massachusetts, dedicated to leveraging the body's natural biology to repair or reverse damage from various degenerative diseases. The company employs a unique Progenitor Cell Activation approach, utilizing combinations of small molecules to stimulate progenitor cells to regenerate functional tissue. Its lead product candidate, FX-322, is currently undergoing phase 2a clinical trials aimed at addressing the underlying causes of sensorineural hearing loss. In addition to hearing loss, Frequency Therapeutics is developing therapies for a variety of degenerative conditions, including multiple sclerosis and ailments affecting muscle, skin, gastrointestinal tract, and bone health. The company has also established a collaboration agreement with Astellas Pharma for the development and commercialization of FX-322. Founded in 2014, Frequency Therapeutics is focused on disease modification through innovative therapeutic strategies.

Frontier Medicines Corporation is a pre-clinical stage biopharmaceutical company based in South San Francisco, California, founded in 2018. The company specializes in discovering and developing medicines that target cancer-causing proteins through its innovative chemoproteomics platform. This platform utilizes advanced computational techniques and machine learning to identify new binding pockets on proteins, thereby facilitating the discovery and development of small-molecule drugs. By enhancing the drug development process, Frontier Medicines aims to deliver breakthrough therapies that can significantly change the treatment landscape for debilitating diseases.

Aerie Pharmaceuticals is an ophthalmic pharmaceutical company dedicated to the discovery, development, and commercialization of innovative therapies for various eye diseases, including glaucoma, dry eye, and retinal conditions. The company's key products include Rhopressa, a once-daily eye drop that lowers elevated intraocular pressure in glaucoma patients, and Rocklatan, a fixed-dose combination of Rhopressa and latanoprost for treating open-angle glaucoma and ocular hypertension. Additionally, Aerie is advancing its clinical-stage product AVX-012 for dry eye and developing sustained-release implants AR-1105 and AR-13503 for retinal diseases. Established in 2005, Aerie is headquartered in Durham, North Carolina, with research facilities in Research Triangle Park. The company has also formed a collaborative research and development agreement with DSM.

TriNetX, Inc. is a global health research network that facilitates collaboration among healthcare organizations, biopharmaceutical companies, and contract research organizations. The company provides a platform that enables researchers to analyze patient populations and derive real-world evidence, thereby enhancing trial design and improving site selection. Key offerings include TriNetX Live, a cloud-based solution for real-time analytics; TriNetX Research, which delivers longitudinal clinical data; and TriNetX Download, a platform for accessing real-world clinical data. Additionally, TriNetX features Attract Trials for data alignment in collaboration, Natural Language Processing for extracting clinical insights from physician documentation, and specialized tools for oncology research. Established in 2013 and headquartered in Cambridge, Massachusetts, TriNetX also has offices in Sydney, London, and Sao Paulo, and maintains compliance with HIPAA and GDPR regulations.

CathWorks Ltd. is a medical technology company based in Kfar-Saba, Israel, with an additional office in the United States. Founded in 2013, CathWorks specializes in developing advanced medical devices for the interventional cardiology market. The company's innovative technology leverages computational science and automatic multi-layered algorithms to enhance the utility of coronary angiography data, transforming visual assessments into objective decision-making tools for physicians. Its flagship product, CathWorks FFRangio, is a non-invasive device that provides objective multi-vessel physiological measurements, aimed at optimizing and confirming intra-procedural decisions for percutaneous coronary interventions (PCI). CathWorks is privately held and benefits from strong partnerships and support from leading venture capital firms in the medical devices sector.

Black Diamond Therapeutics is a precision oncology medicine company focused on discovering and developing small molecule, tumor-agnostic therapies. The company's lead product candidate, BDTX-189, is designed to inhibit specific mutations in ErbB kinases, including the epidermal growth factor receptor. Additionally, Black Diamond is advancing a pipeline of allosteric-EGFR mutation inhibitors and other early-stage programs targeting allosteric mutations in kinases associated with cancer and rare genetic diseases. The company employs a technology platform known as Mutation-Allostery-Pharmacology, which aims to address undrugged mutations in patients with genetically defined cancers. Founded in 2014 and based in Cambridge, Massachusetts, Black Diamond Therapeutics was previously known as ASET Therapeutics until its rebranding in 2018.

Schrödinger is a healthcare software company that specializes in computational drug design, serving the biopharmaceutical and biotechnology sectors. Founded in 1990, the company operates through two main segments: Software and Drug Discovery. Its software solutions facilitate drug discovery processes for pharmaceutical and industrial clients, as well as academic and governmental research institutions. In addition to software sales, Schrödinger engages in drug discovery through its own preclinical and clinical programs, often collaborating with other organizations. The company is committed to advancing its computational platform by investing in scientific research and talent, and it has established partnerships and collaborations across more than 70 countries. With a workforce of over 400 employees, Schrödinger continues to influence the life sciences and materials science industries through innovative approaches to drug discovery.

InCarda Therapeutics, Inc., a clinical-stage biopharmaceutical company, develops transformative therapies for cardiovascular diseases that enable patients to use in the first moments of acute cardiovascular symptoms. The company develops an inhaled therapy intended to treat paroxysmal atrial fibrillation. InCarda Therapeutics, Inc. was formerly known as Pleiades Cardio-Therapeutics, Inc. and changed its name to InCarda Therapeutics, Inc. in May 2011. The company was founded in 2009 and is based in Newark, California.

SHINE Medical Technologies, Inc. manufactures and supplies medical tracers and cancer treatment elements. The company offers Molybdenum-99, a light-emitting element that is administered to patients for the purpose of diagnosing and staging cancer and heart diseases. It also provides Iodine-131 that is used to treat thyroid cancer and various abnormal thyroid conditions, including hyperthyroidism, as well as to diagnose liver function, renal blood flow, and urinary tract obstruction. The company was founded in 2010 and headquartered in Wisconsin, United States.

Tris Pharma, Inc. is a specialty pharmaceutical company based in Monmouth Junction, New Jersey, that focuses on the research, development, manufacturing, and marketing of over-the-counter, prescription branded, and specialty generic products in the United States. The company specializes in extended release formulations tailored for children, seniors, and adults who have difficulty swallowing pills. Tris Pharma has developed several proprietary technologies, including OralXR+, which delivers medication over time using small particles, and Nobuse, an abuse-resistant technology. The product portfolio includes immediate and extended release formulations, lipophilic drugs, and Tuzistra XR, an extended-release oral suspension for cough relief. The company offers a diverse range of dosage forms, including suspensions, chewable tablets, and film strips, and has a pipeline of products targeting cough and cold, pain management, and neurological disorders. Established in 2000, Tris Pharma holds over 30 U.S. patents and has successfully commercialized numerous products in the market through both internal resources and licensing agreements.

Since its formation in 1992, Trinity Biotech has actively pursued the aim of becoming a leading player in the international diagnostics industry. A combination of strong organic growth and a progressive acquisition-led strategy has seen the company assemble an impressive portfolio of over 400 products to date.

Pinnacle Hill is a collaboration between the University of North Carolina at Chapel Hill and Deerfield Management, focused on discovering new medicines to address significant unmet medical needs. The company develops therapeutic medical drugs targeting diseases such as multiple myeloma and Angelman syndrome. Its innovative approach aims to replace or reactivate the faulty UBE3A gene in affected nerve cells, providing healthcare professionals with new treatment options for patients facing life-threatening conditions. Deerfield Management contributes up to $65 million in targeted funding and offers drug development expertise to enhance the promising therapeutic research at UNC-Chapel Hill.

ARS Pharmaceuticals is a stealth pharmaceutical company that developed a novel intranasal epinephrine spray with a unique absorption technology that could be easy-to-use, convenient, and more reliable for patients and loved ones at risk of severe allergic reactions to food, medications and insect bites that could lead to life-threatening anaphylaxis.

Epic Sciences, Inc. is a diagnostics company based in San Diego, California, that specializes in developing sensitive tests for identifying and molecularly characterizing circulating tumor cells (CTCs) from minimally invasive blood samples. The company utilizes a platform that profiles single-cell phenotype and genotype, offering insights into phenotypic measures, specific biomarker expression levels, subcellular biomarker localization, and morphologic characteristics. Additionally, Epic Sciences provides the Oncotype DX AR-V7 Nucleus Detect test for patients with metastatic castration-resistant prostate cancer and offers solutions for biopharmaceutical companies. The company collaborates with various biotechnology and pharmaceutical firms, as well as major cancer centers and research institutions, to enhance cancer management and guide personalized medicine. Founded in 2008, Epic Sciences is dedicated to improving access to real-time biopsy material for better patient outcomes.