Refactor Ivy

Refactor Capital is a venture capital firm based in Burlingame, California, founded in 2016. The firm specializes in seed-stage investments and focuses on early-stage companies addressing fundamental human challenges, particularly in the bio and health sectors. Refactor aims to support innovative founders who are developing solutions in various areas, including pharmaceuticals and biotechnology. The firm is managed by experienced professionals, including Founding Partner Zal Bilimoria.

Zal Bilimoria

Founding Partner

79 past transactions

Macro Oceans

Seed Round in 2023
Developer of a multi-product zero-waste system designed to accelerate the transition to a cleaner, bio-based economy and help restore the oceans' vitality. The company's technology specializes in processing seaweed using a gentle extraction process to preserve the unique bioactive compounds and produces a range of all-natural, quality functional plant-based ingredients, building bioplastics for packaging and more, enabling companies to meet their customer expectations with products like bioplastics that are carbon-neutral, fully-traceable and good for the environment.

YourChoice Therapeutics

Series A in 2022
YourChoice Therapeutics, Inc. is a biotechnology company focused on developing and manufacturing non-hormonal contraceptive products for women. Founded in 2018 and headquartered in Berkeley, California, the company has created a technology that utilizes an active compound to inhibit sperm motility, thereby preventing fertilization. This innovative approach aims to provide safer birth control options that eliminate the risks associated with traditional hormonal methods, offering users a solution with potentially fewer side effects. The company's commitment to advancing reproductive health is reflected in its focus on developing effective and safe contraceptive alternatives.

FYTO

Series A in 2022
FYTO provides innovative solutions which improve the economic and environmental sustainability of agriculture for farmers around the world. FYTO is developing: NOVEL NUTRIENT-DENSE CROPS that have ultra-high yields and ultra-low resource requirements, STATE-OF-THE ART CULTIVATION AND HARVESTING SYSTEMS for exceptional quality and consistency, CLIMATE-FRIENDLY METHODOLOGIES for resiliency and long-term sustainability, and a range of GROUNDBREAKING AGRICULTURAL PRODUCTS such as animal feed and biofertilizer.

Ness

Seed Round in 2022
Provider of a wellness card intended to keep customers healthy. The company specializes in creating health cards that earn rewards for healthy purchases and access perks to complement their lifestyle, enabling users to get free sessions at their favorite workout studios and discounts on health and wellness subscriptions.

Evernow

Series A in 2022
Developer of an online teleconsultation platform designed to guide women during and after menopause. The company's platform has online access to specialized doctors, science-backed pieces of information and treatments with conversations and information about effective care for changing hormones, enabling women to live longer and healthier lives.

Mori

Series B in 2022
Mori, officially known as Cambridge Crops, Inc., specializes in the development of an innovative biopolymer coating designed to extend the shelf life of perishable foods. Established in 2016 and headquartered in Boston, Massachusetts, the company utilizes a unique process that extracts protein from natural silk using salt and water. This edible and natural coating forms a protective layer over various food items, including fruits, vegetables, meat, and seafood, effectively slowing down spoilage. Through its technology, Mori aims to enhance the freshness of food while promoting sustainability in the food supply chain.

64x Bio

Series A in 2022
64x Bio is a biotechnology company based in San Francisco, California, founded in 2017 by Alexis Rovner, George Church, Jeffrey Way, and Pamela Silver. The company specializes in designing microorganisms with enhanced properties to facilitate advanced applications in biomanufacturing, bioremediation, and health. By creating cells tailored for specific purposes, 64x Bio aims to enable innovative solutions that were previously unattainable in these fields.

Phytoform

Seed Round in 2021
Phytoform Labs is a biotechnology company which aims to help breeders to cut down plant breeding times from decades to years using new gene editing technologies. Predictably evolving plants will maximise yields for breeders and improve the economics of breeding for customers.

Mythic Therapeutics

Series B in 2021
Mythic Therapeutics is a biotechnology company focused on a new generation of groundbreaking cancer therapeutics. The company is pioneering a powerful protein engineering-focused approach to improving the effectiveness of antibody-drug conjugates (ADCs) and other antibody-based therapeutics. Their technology dramatically increases therapeutic potency without compromising safety, thereby unlocking the full potential of targeted therapies against a broad array of tumor targets. Mythic Therapeutics was founded in 2017 and is headquartered in Waltham, MA, USA.

Ophelia

Series B in 2021
Ophelia Health, Inc. specializes in medication-assisted treatment for individuals struggling with opioid dependence. The company employs a digital platform to facilitate teleconferenced consultations between patients and licensed clinicians, allowing for convenient access to treatment from home. Ophelia provides not only prescription medications but also therapeutic support, aiming to eliminate the stigma often associated with traditional rehabilitation programs. Founded in 2019 and based in Philadelphia, Pennsylvania, Ophelia emphasizes a patient-centered approach that respects individual choices and prioritizes privacy. The organization combines expertise from various fields, including medicine and technology, to deliver evidence-based care and support to those seeking to overcome opioid addiction.

Solugen

Series C in 2021
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

Solugen

Series C in 2021
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

Knowde

Series B in 2021
Knowde is an online marketing platform and marketplace focused on the chemicals and ingredients sector. It facilitates connections between suppliers and customers by allowing users to create product pages that enhance visibility in search engine results. The platform leverages advanced technologies, including deep learning, to streamline the trading process for chemicals, polymers, and industrial ingredients. By enabling clients to search, filter, sample, quote, and purchase products conveniently, Knowde aims to simplify the sourcing experience, making it easier for customers to compare offerings from various suppliers worldwide. The service is designed to be user-friendly, allowing businesses to build their product pages quickly and begin their marketing efforts at no initial cost.

PathAI

Series C in 2021
PathAI, Inc. develops artificial intelligence-based technology solutions for pathology laboratories. It develops a technology that assists pathologists in making rapid and accurate diagnoses for patients. The company also builds solutions to help identify patients that benefit from novel therapies, to make scalable personalized medicine a reality. PathAI, Inc. was founded in 2016 and is based in Boston, Massachusetts with an additional office in Austin, Texas.

Ophelia

Series A in 2021
Ophelia Health, Inc. specializes in medication-assisted treatment for individuals struggling with opioid dependence. The company employs a digital platform to facilitate teleconferenced consultations between patients and licensed clinicians, allowing for convenient access to treatment from home. Ophelia provides not only prescription medications but also therapeutic support, aiming to eliminate the stigma often associated with traditional rehabilitation programs. Founded in 2019 and based in Philadelphia, Pennsylvania, Ophelia emphasizes a patient-centered approach that respects individual choices and prioritizes privacy. The organization combines expertise from various fields, including medicine and technology, to deliver evidence-based care and support to those seeking to overcome opioid addiction.

Mori

Series B in 2021
Mori, officially known as Cambridge Crops, Inc., specializes in the development of an innovative biopolymer coating designed to extend the shelf life of perishable foods. Established in 2016 and headquartered in Boston, Massachusetts, the company utilizes a unique process that extracts protein from natural silk using salt and water. This edible and natural coating forms a protective layer over various food items, including fruits, vegetables, meat, and seafood, effectively slowing down spoilage. Through its technology, Mori aims to enhance the freshness of food while promoting sustainability in the food supply chain.

Astranis

Series C in 2021
Astranis Space Technologies Corp. is a San Francisco-based company that designs and manufactures small telecommunications satellites aimed at enhancing Internet connectivity. Founded in 2015, Astranis specializes in its MicroGEO technology for geostationary orbit, enabling efficient data transmission to specific terrestrial locations. The company's primary mission is to bridge the digital divide by providing high-speed, reliable internet access to underserved regions at a significantly lower cost than traditional methods. By focusing on connecting the four billion people worldwide who currently lack internet access, Astranis aims to empower governments and businesses to expand internet connectivity and facilitate communication across the globe.

Orchid

Seed Round in 2021
Orchid is a reproductive technology startup that specializes in detecting genetic disorders through advanced genomic analysis. Founded in 2019 and headquartered in San Francisco, California, Orchid offers a preconception system that evaluates both partners' genomes to identify predispositions to various common diseases, including heart disease, diabetes, and certain cancers. Utilizing an at-home saliva test, Orchid provides couples with a detailed "Couple Report" that assesses genetic risks and models the potential genetic combination of a future child. If elevated risks are identified, the company offers valuable insights to help couples manage these risks, which may include monitoring biomarkers or considering options like in vitro fertilization. Orchid's results are developed in collaboration with leading experts in reproductive medicine and genetics, ensuring accuracy and reliability for its clients.

Orchid

Seed Round in 2021
Orchid is a reproductive technology startup that specializes in detecting genetic disorders through advanced genomic analysis. Founded in 2019 and headquartered in San Francisco, California, Orchid offers a preconception system that evaluates both partners' genomes to identify predispositions to various common diseases, including heart disease, diabetes, and certain cancers. Utilizing an at-home saliva test, Orchid provides couples with a detailed "Couple Report" that assesses genetic risks and models the potential genetic combination of a future child. If elevated risks are identified, the company offers valuable insights to help couples manage these risks, which may include monitoring biomarkers or considering options like in vitro fertilization. Orchid's results are developed in collaboration with leading experts in reproductive medicine and genetics, ensuring accuracy and reliability for its clients.

Brave Care

Series A in 2021
Brave Care, Inc. is a healthcare provider specializing in urgent pediatric services. Founded in 2017 and based in Portland, Oregon, the company operates clinics that address a variety of childhood illnesses and injuries. Services offered include treatment for allergies, asthma, coughs, ear pain, eye problems, fever, and urinary tract infections. Brave Care also provides care for minor fractures, strains, sprains, and head trauma, along with pediatric-specific laboratory services and on-site x-ray capabilities. The clinics are equipped to perform procedures such as stitches and tissue glue application for wound closure, as well as mild sedation for uncomfortable treatments.

Rubedo

Seed Round in 2020
Rubedo Life Sciences, Inc. is a biopharmaceutical company based in Sunnyvale, California, focused on developing therapies for age-related diseases by targeting senescent cells. Incorporated in 2018, the company utilizes its ALEMBIC drug discovery platform to create a pipeline of therapeutic candidates that selectively eliminate senescent cells, as well as pro-inflammatory and pro-fibrotic cell populations resulting from cellular stress and damage. By promoting selective apoptosis in aged or pathological tissues, Rubedo aims to regenerate tissues, improve the function of healthy cells, and ultimately extend the health span of patients. The company is dedicated to addressing the challenges posed by age-related conditions through innovative therapeutic solutions.

64x Bio

Seed Round in 2020
64x Bio is a biotechnology company based in San Francisco, California, founded in 2017 by Alexis Rovner, George Church, Jeffrey Way, and Pamela Silver. The company specializes in designing microorganisms with enhanced properties to facilitate advanced applications in biomanufacturing, bioremediation, and health. By creating cells tailored for specific purposes, 64x Bio aims to enable innovative solutions that were previously unattainable in these fields.

Curative

Seed Round in 2020
Curative is a healthcare provider focused on enhancing access to essential medical services. The company specializes in COVID-19 testing, offering a 24-hour service that utilizes a more efficient and precise oral fluid test, thereby alleviating strain on medical supply chains and healthcare workers. In addition to testing, Curative provides a range of services including vaccinations, baseline health visits, and virtual urgent care, all designed to facilitate easier access to healthcare for individuals. This commitment to improving healthcare accessibility positions Curative as a significant player in the health insurance sector, catering to the needs of diverse communities.

ANA Therapeutics

Seed Round in 2020
ANA Therapeutics is a developer of a novel coronavirus vaccine intended to save human lives. It is developing therapeutics to solve the coronavirus pandemic using Niclosamide that enables medical practitioners to treat patients suffering from COVID-19. It was founded in 2020 and is headquartered in Foster City, California.

Mori

Series A in 2020
Mori, officially known as Cambridge Crops, Inc., specializes in the development of an innovative biopolymer coating designed to extend the shelf life of perishable foods. Established in 2016 and headquartered in Boston, Massachusetts, the company utilizes a unique process that extracts protein from natural silk using salt and water. This edible and natural coating forms a protective layer over various food items, including fruits, vegetables, meat, and seafood, effectively slowing down spoilage. Through its technology, Mori aims to enhance the freshness of food while promoting sustainability in the food supply chain.

Magic

Seed Round in 2020
Get peace of mind with secure, extensible passwordless authentication that’s built to scale. All with a few lines of code.

Ophelia

Seed Round in 2020
Ophelia Health, Inc. specializes in medication-assisted treatment for individuals struggling with opioid dependence. The company employs a digital platform to facilitate teleconferenced consultations between patients and licensed clinicians, allowing for convenient access to treatment from home. Ophelia provides not only prescription medications but also therapeutic support, aiming to eliminate the stigma often associated with traditional rehabilitation programs. Founded in 2019 and based in Philadelphia, Pennsylvania, Ophelia emphasizes a patient-centered approach that respects individual choices and prioritizes privacy. The organization combines expertise from various fields, including medicine and technology, to deliver evidence-based care and support to those seeking to overcome opioid addiction.

Knowde

Series A in 2020
Knowde is an online marketing platform and marketplace focused on the chemicals and ingredients sector. It facilitates connections between suppliers and customers by allowing users to create product pages that enhance visibility in search engine results. The platform leverages advanced technologies, including deep learning, to streamline the trading process for chemicals, polymers, and industrial ingredients. By enabling clients to search, filter, sample, quote, and purchase products conveniently, Knowde aims to simplify the sourcing experience, making it easier for customers to compare offerings from various suppliers worldwide. The service is designed to be user-friendly, allowing businesses to build their product pages quickly and begin their marketing efforts at no initial cost.

Avail Medsystems

Series A in 2020
Avail Medsystems, Inc. is a medical technology company based in Palo Alto, California, focused on enhancing connectivity in healthcare settings through its innovative software platform. This platform allows healthcare experts to remotely support practitioners during medical procedures, facilitating real-time collaboration and clinical education. By digitizing the physical presence typically required in operating rooms, Avail Medsystems aims to democratize access to essential clinical expertise, thereby overcoming physical, economic, and logistical barriers. The company's Procedural Telemedicine solution enables healthcare professionals to connect seamlessly with remote specialists, ensuring that quality care and guidance are always accessible. Founded in 2012 and formerly known as Nurep, Inc., Avail Medsystems has positioned itself at the forefront of integrating technology into medical practices.

Uniform Teeth

Series A in 2019
Uniform Teeth is an orthodontics practice focused on providing modern and accessible orthodontic care. The company operates dental clinics that specialize in clear teeth aligners, which are crafted from biocompatible, BPA-free plastic designed to fit the patient's teeth at each stage of treatment. By prioritizing quality and intuitiveness in their services, Uniform Teeth aims to simplify the orthodontic experience for patients seeking to straighten their teeth.

Uniform Teeth

Series A in 2019
Uniform Teeth is an orthodontics practice focused on providing modern and accessible orthodontic care. The company operates dental clinics that specialize in clear teeth aligners, which are crafted from biocompatible, BPA-free plastic designed to fit the patient's teeth at each stage of treatment. By prioritizing quality and intuitiveness in their services, Uniform Teeth aims to simplify the orthodontic experience for patients seeking to straighten their teeth.

Redesign Science

Seed Round in 2019
Redesign Science Inc is a biotechnology company based in New York, established in 2017, that specializes in small molecule drug discovery. The company employs advanced techniques, including first-principles physics and artificial intelligence, to simulate protein targets at the atomic level. This approach allows Redesign Science to identify subtle drug opportunities that conventional computational models may overlook. By focusing on the development of first-in-class small molecules, the company aims to address emerging and challenging targets associated with significant unmet medical needs. Their innovative methodologies not only enhance the understanding of biological pathways and disease mechanisms but also drive the commercialization of new therapeutic solutions.

Tempest

Series A in 2019
Tempest, Inc. operates an online recovery school that provides a virtual course for individuals seeking to quit alcohol. Founded in 2014 and based in New York, the company offers a range of resources, including email courses, counseling sessions, and workshops designed to support those struggling with alcohol addiction. Its programs focus on helping participants understand the significance of purpose, meaning, and creativity in leading a sober life. Tempest aims to empower users to confront the challenges related to alcohol consumption and associated mental health issues, ultimately enabling them to achieve a healthier and more balanced lifestyle. Formerly known as Hip Sobriety, Inc., the company rebranded to Tempest, Inc. in May 2019.

Brave Care

Seed Round in 2019
Brave Care, Inc. is a healthcare provider specializing in urgent pediatric services. Founded in 2017 and based in Portland, Oregon, the company operates clinics that address a variety of childhood illnesses and injuries. Services offered include treatment for allergies, asthma, coughs, ear pain, eye problems, fever, and urinary tract infections. Brave Care also provides care for minor fractures, strains, sprains, and head trauma, along with pediatric-specific laboratory services and on-site x-ray capabilities. The clinics are equipped to perform procedures such as stitches and tissue glue application for wound closure, as well as mild sedation for uncomfortable treatments.

Mori

Seed Round in 2019
Mori, officially known as Cambridge Crops, Inc., specializes in the development of an innovative biopolymer coating designed to extend the shelf life of perishable foods. Established in 2016 and headquartered in Boston, Massachusetts, the company utilizes a unique process that extracts protein from natural silk using salt and water. This edible and natural coating forms a protective layer over various food items, including fruits, vegetables, meat, and seafood, effectively slowing down spoilage. Through its technology, Mori aims to enhance the freshness of food while promoting sustainability in the food supply chain.

Umbrella

Seed Round in 2019
Umbrella, Inc. is a Brooklyn-based company that offers home maintenance services on a membership basis, catering primarily to senior citizens. Founded in 1995, the company provides a range of services designed to assist with everyday home chores and maintenance. These services include home repair, seasonal tasks, plumbing, and cleaning, along with specific tasks such as carpentry, light fixture changes, and air conditioner installation. Umbrella's task management platform connects seniors with community members who can perform small, temporary jobs, thereby enabling older adults to maintain their independence and continue living comfortably in their own homes.

Solugen

Series B in 2019
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

Kin Euphorics

Venture Round in 2019
Kin Euphorics is a New York-based company, founded in 2017, that specializes in non-alcoholic beverages designed to enhance social experiences. The company's offerings include ready-to-drink tonics made from a combination of nootropics, adaptogens, and botanicals. These functional beverages aim to promote a sense of focused relaxation, helping consumers unwind without inducing sleepiness or compromising cognitive function. Kin Euphorics targets individuals seeking a balanced and nourishing alternative to traditional alcoholic drinks, allowing them to enjoy social interactions while supporting their mental well-being.

Vital

Seed Round in 2019
Vital Software Inc. is a provider of cloud-based software specifically designed for emergency departments in hospitals. Founded in 2017 and headquartered in Atlanta, Georgia, the company focuses on enhancing patient experiences and optimizing operational flow within emergency rooms. Its software leverages artificial intelligence to predict patient admissions and offers real-time updates regarding patients' next steps and estimated wait times. This technology allows clinicians to spend less time on electronic health records and ensures seamless communication with patients and their families, ultimately improving efficiency and potentially reducing costs for healthcare facilities.

Culture Biosciences

Venture Round in 2019
Culture Biosciences, founded in 2016 and headquartered in San Francisco, California, specializes in developing automated bioreactors and tools for fermentation. The company provides a digital bio-manufacturing platform that allows biotech companies to optimize their manufacturing processes, enabling them to bring products to market more efficiently. By utilizing robotic sample handling and cloud-based data monitoring and analysis, Culture Biosciences helps scientists run, monitor, and analyze bioreactors more quickly than traditional methods. This innovative approach supports the biotechnology sector in enhancing productivity and streamlining workflows.

AKASA

Seed Round in 2019
Alpha Health LLC specializes in developing a unified automation platform for healthcare revenue cycle management, aimed at reducing the cost of care for health systems. Founded in 2018 and based in South San Francisco, California, the company leverages advanced machine learning techniques to streamline complex medical reimbursement processes. Its platform captures multimodal data to offer a comprehensive view of existing workflows, identifying and correcting inefficiencies to eliminate unnecessary tasks. By integrating human expertise with data and technology, Alpha Health enhances the efficiency and accuracy of revenue management, enabling healthcare providers to be more effective stewards of healthcare resources.

Cambridge Cancer Genomics

Seed Round in 2018
Cambridge Cancer Genomics Limited offers diagnostics tests for cancer patients using liquid biopsy, artificial intelligence, and genomics. It uses artificial neural networks and machine learning algorithms to design personalized tests for tracking treatment response in patients. The company enables cancer clinics, academic institutes, biotech startups, and pharmaceutical companies to make use of the tools and therapies. Cambridge Cancer Genomics Limited was incorporated in 2017 and is based in Cambridge, United Kingdom.

Knowde

Seed Round in 2018
Knowde is an online marketing platform and marketplace focused on the chemicals and ingredients sector. It facilitates connections between suppliers and customers by allowing users to create product pages that enhance visibility in search engine results. The platform leverages advanced technologies, including deep learning, to streamline the trading process for chemicals, polymers, and industrial ingredients. By enabling clients to search, filter, sample, quote, and purchase products conveniently, Knowde aims to simplify the sourcing experience, making it easier for customers to compare offerings from various suppliers worldwide. The service is designed to be user-friendly, allowing businesses to build their product pages quickly and begin their marketing efforts at no initial cost.

Solugen

Series A in 2018
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

Hero

Series A in 2018
Hero Health, Inc. specializes in the development of an in-home medication management system designed to assist patients and caregivers in effectively managing medication regimens. Founded in 2018 and headquartered in New York, the company offers a comprehensive solution that includes a countertop device capable of sorting and dispensing medications, along with a mobile application that organizes and manages medication schedules. The system features audible and digital reminders, automates refills, and provides both real-time and historical adherence data, enhancing visibility for patients with chronic conditions. By leveraging digital technologies, Hero Health aims to improve patient engagement and outcomes through better medication monitoring and management.

Blockfolio

Series A in 2018
Blockfolio, Inc. is a mobile application designed for cryptocurrency portfolio tracking and management, catering to the needs of the cryptocurrency and blockchain industry. Founded in 2014 and based in Marina Del Rey, California, the application allows users to create and manage their cryptocurrency portfolios while staying informed about market prices, data, and news. Users can track market movements and receive updates directly from leaders of prominent cryptocurrency projects. The platform automates portfolio management by integrating with various exchange accounts, making it easier for users to monitor their investments. Blockfolio operates as a subsidiary of FTX Trading LTD and is dedicated to providing free access to its services, fostering a strong connection between users and the evolving cryptocurrency landscape.

FactoryFour

Series A in 2018
FactoryFour is a software company based in Baltimore, Maryland, founded in 2015, specializing in manufacturing execution systems (MES). Its solutions are designed to manage and automate manufacturing processes, particularly in the realm of digital fabrication, making it a viable service for mass manufacturing. The company's cloud-based software offers highly customizable and user-friendly tools that enhance productivity and profitability by providing real-time data on manufacturing operations. This enables clients to effectively plan production, prioritize orders, and automate scheduling with adaptable logic tailored to their specific needs. By facilitating the capture and analysis of operational data, FactoryFour empowers businesses to improve their manufacturing efficiency and decision-making capabilities.

Checkerspot

Seed Round in 2018
Checkerspot, Inc. is a biotechnology company based in Berkeley, California, founded in 2016. The company specializes in producing performance materials derived from microalgae, leveraging advancements in biology, chemistry, and materials science. Checkerspot's innovative technology platform enables the design of new materials at the molecular level, allowing for the creation of tailored solutions for various industrial applications. By integrating molecular foundry techniques with fermentation processes, the company develops sustainable materials, including polyurethanes and textile finishes, that meet the specific needs of product designers. Checkerspot collaborates closely with product users and socially responsible corporations to prototype and iterate on products, ultimately bringing superior materials to market that promote sustainability and enhanced performance.

Shield Bio

Series A in 2018
At Shield, we’re ensuring that antibiotic resistance doesn’t become more deadly than cancer. In 2050 more people will be dying of antibiotic resistant pathogens than cancer. Infections that were once treatable with a simple oral antibiotics are now requiring complex, painful treatments and resulting in serious health complications for patients. Gonorrhea is one such infection, having become resistant to over 10 different antibiotics, they have only one treatment that is still effective and resistance to this has already begun to emerge. With 820,000 new infections every year in the US, antibiotic resistance will spread quickly, which is why the CDC has resistant gonorrhea at an urgent threat level, the highest level available. Shield's novel genomic testing platform enables STI clinics to identify the antibiotic resistant strains of gonorrhea and other pathogens that their patients have, so they can select the correct antibiotics and halt the spread of antibiotic resistance.

Biobot Analytics

Seed Round in 2018
Biobot Analytics, Inc. is a wastewater epidemiology company based in Cambridge, Massachusetts, founded in 2017. The company specializes in transforming sewer systems into public health observatories through innovative technology that analyzes wastewater samples. By deploying proprietary sampling devices and spatial analytics, Biobot measures various health threats, including infectious disease outbreaks, antibiotic resistance, and fluctuations in drug consumption. One of its key initiatives is the Opioid Consumption Monitoring Program, which assesses opioid usage by analyzing sewage to provide estimates of drug consumption in urban areas. This approach creates a health database that operates independently of traditional hospital reporting systems, enabling rapid adaptation to emerging public health challenges while minimizing societal biases in healthcare access.

Astranis

Series A in 2018
Astranis Space Technologies Corp. is a San Francisco-based company that designs and manufactures small telecommunications satellites aimed at enhancing Internet connectivity. Founded in 2015, Astranis specializes in its MicroGEO technology for geostationary orbit, enabling efficient data transmission to specific terrestrial locations. The company's primary mission is to bridge the digital divide by providing high-speed, reliable internet access to underserved regions at a significantly lower cost than traditional methods. By focusing on connecting the four billion people worldwide who currently lack internet access, Astranis aims to empower governments and businesses to expand internet connectivity and facilitate communication across the globe.

Uniform Teeth

Seed Round in 2018
Uniform Teeth is an orthodontics practice focused on providing modern and accessible orthodontic care. The company operates dental clinics that specialize in clear teeth aligners, which are crafted from biocompatible, BPA-free plastic designed to fit the patient's teeth at each stage of treatment. By prioritizing quality and intuitiveness in their services, Uniform Teeth aims to simplify the orthodontic experience for patients seeking to straighten their teeth.

PathAI

Series A in 2017
PathAI, Inc. develops artificial intelligence-based technology solutions for pathology laboratories. It develops a technology that assists pathologists in making rapid and accurate diagnoses for patients. The company also builds solutions to help identify patients that benefit from novel therapies, to make scalable personalized medicine a reality. PathAI, Inc. was founded in 2016 and is based in Boston, Massachusetts with an additional office in Austin, Texas.

Solugen

Seed Round in 2017
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

Octant Bio

Seed Round in 2017
Octant Bio is focused on advancing health and treating complex diseases through innovative synthetic technology. The company utilizes a combination of synthetic biology, genome engineering, next-generation sequencing, and computational methods to assess the activity of numerous receptor pathways within human cells. This approach allows for the development of multi-targeted small molecule drug leads by leveraging machine learning to engineer compounds that interact with multiple receptors. By generating extensive multi-receptor pathway data, Octant Bio aims to enhance rational drug design and uncover new therapeutic possibilities. Founded in 2017 and based in Los Angeles, California, Octant Bio is dedicated to transforming the landscape of drug discovery and development.

Enzyme

Seed Round in 2017
Enzyme develops a cloud-based platform that assists life sciences companies in navigating FDA approval and regulatory compliance. By automating and simplifying compliance workflows, the platform helps organizations reduce their reliance on expensive consultants, potentially cutting compliance costs by up to 50 percent. Additionally, it addresses the significant personnel burden associated with regulatory issues, which affects about 10 percent of the workforce in biopharma and life sciences, potentially lowering headcount requirements. Enzyme's software not only streamlines compliance monitoring but also ensures adherence to FDA standards, allowing medical device, diagnostic, and drug development businesses to expedite the process of bringing their products to market while minimizing legal risks.

Knowde

Pre Seed Round in 2017
Knowde is an online marketing platform and marketplace focused on the chemicals and ingredients sector. It facilitates connections between suppliers and customers by allowing users to create product pages that enhance visibility in search engine results. The platform leverages advanced technologies, including deep learning, to streamline the trading process for chemicals, polymers, and industrial ingredients. By enabling clients to search, filter, sample, quote, and purchase products conveniently, Knowde aims to simplify the sourcing experience, making it easier for customers to compare offerings from various suppliers worldwide. The service is designed to be user-friendly, allowing businesses to build their product pages quickly and begin their marketing efforts at no initial cost.

Cofactor Genomics

Series A in 2017
Cofactor Genomics is a biotechnology company focused on advancing precision medicine through predictive immune modeling. By leveraging its expertise in RNA sequencing and expression analysis, Cofactor aims to move beyond traditional single-analyte biomarkers to develop multidimensional biomarkers that enhance clinical insights. The company's platform examines RNA biomarkers linked to responses to targeted therapeutics, allowing biotechnology firms to create clinical diagnostic assays for oncology, immunology, and neurodegenerative diseases. With a CAP-certified clinical RNA sequencing laboratory and a suite of molecular, informatic, and database tools, Cofactor supports its partners in conducting more efficient and successful clinical trials, ultimately facilitating the commercialization of innovative therapeutic solutions.

Cofactor Genomics

Series A in 2017
Cofactor Genomics is a biotechnology company focused on advancing precision medicine through predictive immune modeling. By leveraging its expertise in RNA sequencing and expression analysis, Cofactor aims to move beyond traditional single-analyte biomarkers to develop multidimensional biomarkers that enhance clinical insights. The company's platform examines RNA biomarkers linked to responses to targeted therapeutics, allowing biotechnology firms to create clinical diagnostic assays for oncology, immunology, and neurodegenerative diseases. With a CAP-certified clinical RNA sequencing laboratory and a suite of molecular, informatic, and database tools, Cofactor supports its partners in conducting more efficient and successful clinical trials, ultimately facilitating the commercialization of innovative therapeutic solutions.

Call9

Series B in 2017
Call9, Inc. is a healthcare technology company based in Brooklyn, New York, that specializes in connecting nursing home patients to emergency medical care through its mobile platform. Established in 2015, Call9 offers an alternative to traditional emergency services by allowing skilled nursing facility (SNF) nurses to activate its system during acute medical events. This process ensures that on-site Clinical Care Specialists and Board Certified Emergency Medicine Physicians can provide immediate bedside care using proprietary technology. By facilitating expedited treatment and point-of-care tests, Call9 effectively keeps over 80% of patients within their nursing home, thereby reducing unnecessary hospital admissions and saving costs for the healthcare system. The company's innovative approach aims to redefine telemedicine standards and enhance patient access to emergency care around the clock.

Gencove

Seed Round in 2017
Gencove is a company focused on making genomics affordable and accessible through its innovative low-coverage whole genome sequencing technology. It has developed a sequencing platform that emphasizes speed, cost-effectiveness, and practical applications. By creating molecular and computational tools, Gencove enables high-throughput and low-cost genome sequencing across various industries, including agriculture and pharmaceuticals. This approach allows researchers to access valuable genomic data, facilitating advancements in their respective fields.

Clover Health

Series D in 2017
Clover Health is a health insurance company that specializes in providing Medicare Advantage plans for senior citizens. Founded in 2014 and headquartered in San Francisco, California, the company also has offices in several states, including New Jersey, Arizona, Georgia, Pennsylvania, South Carolina, Tennessee, and Texas. Clover Health operates a Preferred Provider Organization (PPO) platform that aims to enhance the quality of life for its members through patient-centered analytics and dedicated care management. By utilizing advanced analytics and custom software, Clover Health directs its clinical staff to proactively address gaps in care, focusing on preventive measures and chronic disease management. Its approach not only aims to improve health outcomes but also seeks to reduce unnecessary healthcare spending. The company primarily generates revenue through its insurance segment, which offers both PPO and Health Maintenance Organization (HMO) plans.

Plutoshift

Seed Round in 2017
Plutoshift is an operational data platform founded in 2017 and based in Palo Alto, California. The company focuses on empowering operators to automate performance monitoring across various industrial workflows. By leveraging existing data collection systems, Plutoshift enhances data workflows and delivers a unified view of physical infrastructure performance. Its platform aims to drive return on investment for businesses by reducing resource consumption and operating costs. Additionally, Plutoshift facilitates data-driven operations by transferring insights and artificial intelligence from back-office functions to front-line operators, managers, and executives, enabling them to automatically monitor critical processes and access actionable information.

TL Biolabs

Seed Round in 2017
TL Biolabs Corp. is a biotechnology company based in Santa Clara, California, that specializes in automated genomic testing for livestock. Established in 2016, the company focuses on providing cost-effective genomic tests specifically for beef and dairy cattle. In addition to its testing services, TL Biolabs offers complimentary software designed to deliver actionable results, enhancing decision-making for livestock management.

Shield Bio

Seed Round in 2017
At Shield, we’re ensuring that antibiotic resistance doesn’t become more deadly than cancer. In 2050 more people will be dying of antibiotic resistant pathogens than cancer. Infections that were once treatable with a simple oral antibiotics are now requiring complex, painful treatments and resulting in serious health complications for patients. Gonorrhea is one such infection, having become resistant to over 10 different antibiotics, they have only one treatment that is still effective and resistance to this has already begun to emerge. With 820,000 new infections every year in the US, antibiotic resistance will spread quickly, which is why the CDC has resistant gonorrhea at an urgent threat level, the highest level available. Shield's novel genomic testing platform enables STI clinics to identify the antibiotic resistant strains of gonorrhea and other pathogens that their patients have, so they can select the correct antibiotics and halt the spread of antibiotic resistance.

PathAI

Seed Round in 2016
PathAI, Inc. develops artificial intelligence-based technology solutions for pathology laboratories. It develops a technology that assists pathologists in making rapid and accurate diagnoses for patients. The company also builds solutions to help identify patients that benefit from novel therapies, to make scalable personalized medicine a reality. PathAI, Inc. was founded in 2016 and is based in Boston, Massachusetts with an additional office in Austin, Texas.

PathAI

Seed Round in 2016
PathAI, Inc. develops artificial intelligence-based technology solutions for pathology laboratories. It develops a technology that assists pathologists in making rapid and accurate diagnoses for patients. The company also builds solutions to help identify patients that benefit from novel therapies, to make scalable personalized medicine a reality. PathAI, Inc. was founded in 2016 and is based in Boston, Massachusetts with an additional office in Austin, Texas.

Legalist

Seed Round in 2016
Legalist, Inc., founded in 2016 and headquartered in San Francisco, California, specializes in data-backed litigation financing services. The company offers legal data analytics tools that assist small businesses and their legal representatives in navigating the justice system. By providing capabilities such as tracking state trial cases, sending email alerts, and predicting trial timelines, Legalist helps plaintiffs and attorneys manage legal challenges more effectively. Additionally, the firm employs proprietary technology to source and underwrite litigation investments on a non-recourse basis, aiming to mitigate risk and facilitate the payment of legal fees while generating risk-adjusted returns for its clients.

Finova Financial

Venture Round in 2016
Finova Financial LLC, founded in 2015 and based in Palm Beach Gardens, Florida, offers a digital financial services platform that provides affordable loans to consumers based on the equity in their vehicles. Catering to approximately 70 million financially underserved Americans, Finova aims to reduce the high costs associated with traditional lending, offering its Car Equity Line of Credit (C-LOC) at significantly lower rates than the national average. The platform enables clients to access capital quickly, with instant approval decisions and same-day funding available through an online portal. This portal allows users to manage their financial health in real-time, facilitating payments from various devices and at numerous retail locations. Finova’s approach emphasizes building positive relationships with clients, focusing on financial education and support to improve their economic well-being.

Trace Genomics

Seed Round in 2016
Trace Genomics, Inc. specializes in developing artificial intelligence-based diagnostic tools for farmers, focusing on soil health and crop quality. The company offers a soil microbiome test that utilizes DNA sequencing and artificial intelligence to analyze microbial species in agricultural soils. By interpreting key indicators of soil health and disease risk, Trace Genomics enables early predictions of soil diseases, benefiting agronomists and their corporate partners. Founded in 2015 and headquartered in Burlingame, California, with an additional office in Ames, Iowa, Trace Genomics aims to enhance agricultural practices and maximize the value of every acre for the farming community.

Clover Health

Series C in 2016
Clover Health is a health insurance company that specializes in providing Medicare Advantage plans for senior citizens. Founded in 2014 and headquartered in San Francisco, California, the company also has offices in several states, including New Jersey, Arizona, Georgia, Pennsylvania, South Carolina, Tennessee, and Texas. Clover Health operates a Preferred Provider Organization (PPO) platform that aims to enhance the quality of life for its members through patient-centered analytics and dedicated care management. By utilizing advanced analytics and custom software, Clover Health directs its clinical staff to proactively address gaps in care, focusing on preventive measures and chronic disease management. Its approach not only aims to improve health outcomes but also seeks to reduce unnecessary healthcare spending. The company primarily generates revenue through its insurance segment, which offers both PPO and Health Maintenance Organization (HMO) plans.

Astranis

Seed Round in 2016
Astranis Space Technologies Corp. is a San Francisco-based company that designs and manufactures small telecommunications satellites aimed at enhancing Internet connectivity. Founded in 2015, Astranis specializes in its MicroGEO technology for geostationary orbit, enabling efficient data transmission to specific terrestrial locations. The company's primary mission is to bridge the digital divide by providing high-speed, reliable internet access to underserved regions at a significantly lower cost than traditional methods. By focusing on connecting the four billion people worldwide who currently lack internet access, Astranis aims to empower governments and businesses to expand internet connectivity and facilitate communication across the globe.

Kip

Seed Round in 2016
Kip Labs, Inc. is a healthcare technology company based in San Francisco, California, that specializes in enhancing the therapeutic experience for patients and therapists through an innovative application. Founded in 2015, Kip's platform facilitates online communication, allowing users to track their symptoms and progress, share thoughts and notes with their therapists, and work on personalized care plans. By integrating traditional in-person therapy with digital support, Kip aims to improve treatment outcomes and foster measurable results. The application serves users in San Francisco, East Bay, and Silicon Valley, providing a science-backed approach to mental health care that emphasizes ongoing engagement between therapy sessions.

Alloy.ai

Seed Round in 2016
Alloy.ai operates a cloud-based platform that automates the collection and harmonization of retail, e-commerce, and supply chain data using artificial intelligence. This platform empowers consumer goods companies to gain insights into sales and inventory at various levels, from individual stores to specific SKUs. By providing inventory allocation, product forecasts, and order assessments, Alloy.ai enables businesses to achieve a unified view of their sales and inventory performance. The platform also offers retailer-specific metrics and tailored reports for comprehensive analytics on sales and operations. Serving a diverse clientele that includes both Fortune 100 firms and emerging startups, Alloy.ai enhances supply chain visibility and efficiency, allowing companies to respond to demand with agility and optimize their operations. Founded in 2015 and headquartered in San Francisco, Alloy.ai is focused on redefining information flow within the supply chain.

Finova Financial

Seed Round in 2016
Finova Financial LLC, founded in 2015 and based in Palm Beach Gardens, Florida, offers a digital financial services platform that provides affordable loans to consumers based on the equity in their vehicles. Catering to approximately 70 million financially underserved Americans, Finova aims to reduce the high costs associated with traditional lending, offering its Car Equity Line of Credit (C-LOC) at significantly lower rates than the national average. The platform enables clients to access capital quickly, with instant approval decisions and same-day funding available through an online portal. This portal allows users to manage their financial health in real-time, facilitating payments from various devices and at numerous retail locations. Finova’s approach emphasizes building positive relationships with clients, focusing on financial education and support to improve their economic well-being.

Call9

Series A in 2016
Call9, Inc. is a healthcare technology company based in Brooklyn, New York, that specializes in connecting nursing home patients to emergency medical care through its mobile platform. Established in 2015, Call9 offers an alternative to traditional emergency services by allowing skilled nursing facility (SNF) nurses to activate its system during acute medical events. This process ensures that on-site Clinical Care Specialists and Board Certified Emergency Medicine Physicians can provide immediate bedside care using proprietary technology. By facilitating expedited treatment and point-of-care tests, Call9 effectively keeps over 80% of patients within their nursing home, thereby reducing unnecessary hospital admissions and saving costs for the healthcare system. The company's innovative approach aims to redefine telemedicine standards and enhance patient access to emergency care around the clock.

Verge Genomics

Seed Round in 2015
Verge Genomics focuses on accelerating drug discovery for neurodegenerative diseases through the use of artificial intelligence and genomic data. The company has developed a platform that leverages machine learning to analyze large datasets, identifying genetic targets and predicting effective therapeutics. By mapping genes associated with various neurodegenerative conditions, Verge aims to discover drugs that can simultaneously target multiple genetic factors. Founded by experts in machine learning and neuroscience, Verge Genomics seeks to improve patient outcomes and reduce the costs associated with pharmaceutical development. The company is based in Mountain View, California, and has formed a strategic alliance with Datavant to enhance its data-driven approach.

Headspace

Series A in 2015
Headspace is a digital health platform established in 2010 and headquartered in Santa Monica, California, that specializes in guided meditation and mindfulness training. It offers a vast library of content, recognized as one of the most comprehensive secular programs in this field, accessible via mobile and tablet applications. Users can engage in mindfulness practices through various features, including health videos and chat options, which also facilitate access to free meditation sessions. Headspace Health, an extension of the brand, focuses on mental health and well-being, partnering with over 2,500 companies and health plans to provide services that include meditation, mindfulness, coaching, therapy, and psychiatry. Notable partners include major organizations such as Starbucks, Adobe, Delta Air Lines, ViacomCBS, Cigna, and Kaiser Permanente.

PicnicHealth

Seed Round in 2015
PicnicHealth is focused on simplifying access to medical records while utilizing data to advance medical research. The company provides patients with a secure online dashboard that consolidates all their medical records from various healthcare providers across the United States. This platform not only facilitates easy access to personal health information but also allows patients to contribute their anonymized data to scientific research, which aids life sciences researchers in understanding real-world disease experiences and treatment methods. By leveraging this “real-world data,” PicnicHealth aims to enhance treatment options and improve patient outcomes. The company has already assisted tens of thousands of patients, formed partnerships with major biopharma companies, and secured substantial funding from various venture capital firms.
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