Refactor

Refactor Capital is a California-based seed-stage venture capital firm founded in 2016, focusing on early-stage investments across various sectors, particularly in software, commercial services, pharmaceuticals, and biotechnology. The firm aims to support founders who are addressing fundamental human problems, particularly in the bio and health domains. Managed from Burlingame, California, Refactor Capital oversees several venture capital funds, including Refactor Aurora, Refactor Curry, and Refactor Ivy. Zal Bilimoria serves as the Founding Partner, collaborating with David Lee of SV Angel to guide the firm's investment strategy.

Rick Barber

Venture Partner

Zal Bilimoria

Founding Partner

78 past transactions

Macro Oceans

Seed Round in 2023
Developer of a multi-product zero-waste system designed to accelerate the transition to a cleaner, bio-based economy and help restore the oceans' vitality. The company's technology specializes in processing seaweed using a gentle extraction process to preserve the unique bioactive compounds and produces a range of all-natural, quality functional plant-based ingredients, building bioplastics for packaging and more, enabling companies to meet their customer expectations with products like bioplastics that are carbon-neutral, fully-traceable and good for the environment.

YourChoice Therapeutics

Series A in 2022
YourChoice Therapeutics, Inc. is a biotechnology company focused on developing and manufacturing non-hormonal contraceptive products for women. Founded in 2018 and headquartered in Berkeley, California, the company has created a technology that utilizes an active compound to inhibit sperm motility, thereby preventing fertilization. This innovative approach aims to provide safer birth control options that eliminate the risks associated with traditional hormonal methods, offering users a solution with potentially fewer side effects. The company's commitment to advancing reproductive health is reflected in its focus on developing effective and safe contraceptive alternatives.

FYTO

Series A in 2022
FYTO provides innovative solutions which improve the economic and environmental sustainability of agriculture for farmers around the world. FYTO is developing: NOVEL NUTRIENT-DENSE CROPS that have ultra-high yields and ultra-low resource requirements, STATE-OF-THE ART CULTIVATION AND HARVESTING SYSTEMS for exceptional quality and consistency, CLIMATE-FRIENDLY METHODOLOGIES for resiliency and long-term sustainability, and a range of GROUNDBREAKING AGRICULTURAL PRODUCTS such as animal feed and biofertilizer.

Mori

Series B in 2022
Mori, officially known as Cambridge Crops, Inc., specializes in the development of an innovative biopolymer coating designed to extend the shelf life of perishable foods. Established in 2016 and headquartered in Boston, Massachusetts, the company utilizes a unique process that extracts protein from natural silk using salt and water. This edible and natural coating forms a protective layer over various food items, including fruits, vegetables, meat, and seafood, effectively slowing down spoilage. Through its technology, Mori aims to enhance the freshness of food while promoting sustainability in the food supply chain.

64x Bio

Series A in 2022
64x Bio is a biotechnology company based in San Francisco, California, founded in 2017 by Alexis Rovner, George Church, Jeffrey Way, and Pamela Silver. The company specializes in designing microorganisms with enhanced properties to facilitate advanced applications in biomanufacturing, bioremediation, and health. By creating cells tailored for specific purposes, 64x Bio aims to enable innovative solutions that were previously unattainable in these fields.

Phytoform Labs

Seed Round in 2021
Phytoform Labs is a biotechnology company which aims to help breeders to cut down plant breeding times from decades to years using new gene editing technologies. Predictably evolving plants will maximise yields for breeders and improve the economics of breeding for customers.

Mythic Therapeutics

Series B in 2021
Mythic Therapeutics is a biotechnology company focused on a new generation of groundbreaking cancer therapeutics. The company is pioneering a powerful protein engineering-focused approach to improving the effectiveness of antibody-drug conjugates (ADCs) and other antibody-based therapeutics. Their technology dramatically increases therapeutic potency without compromising safety, thereby unlocking the full potential of targeted therapies against a broad array of tumor targets. Mythic Therapeutics was founded in 2017 and is headquartered in Waltham, MA, USA.

Ophelia

Series B in 2021
Ophelia Health, Inc. specializes in medication-assisted treatment for individuals struggling with opioid dependence. The company employs a digital platform to facilitate teleconferenced consultations between patients and licensed clinicians, allowing for convenient access to treatment from home. Ophelia provides not only prescription medications but also therapeutic support, aiming to eliminate the stigma often associated with traditional rehabilitation programs. Founded in 2019 and based in Philadelphia, Pennsylvania, Ophelia emphasizes a patient-centered approach that respects individual choices and prioritizes privacy. The organization combines expertise from various fields, including medicine and technology, to deliver evidence-based care and support to those seeking to overcome opioid addiction.

Solugen

Series C in 2021
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

Solugen

Series C in 2021
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

Knowde

Series B in 2021
knowde is the online marketing platform dedicated to chemicals and ingredients. They make it easy to connect with customers, online. Use knowde Pages to get your products noticed every time a customer searches on any search engine. Build your knowde Page in an hour and get started for free.

PathAI

Series C in 2021
PathAI, Inc. develops artificial intelligence-based technology solutions for pathology laboratories. It develops a technology that assists pathologists in making rapid and accurate diagnoses for patients. The company also builds solutions to help identify patients that benefit from novel therapies, to make scalable personalized medicine a reality. PathAI, Inc. was founded in 2016 and is based in Boston, Massachusetts with an additional office in Austin, Texas.

Ophelia

Series A in 2021
Ophelia Health, Inc. specializes in medication-assisted treatment for individuals struggling with opioid dependence. The company employs a digital platform to facilitate teleconferenced consultations between patients and licensed clinicians, allowing for convenient access to treatment from home. Ophelia provides not only prescription medications but also therapeutic support, aiming to eliminate the stigma often associated with traditional rehabilitation programs. Founded in 2019 and based in Philadelphia, Pennsylvania, Ophelia emphasizes a patient-centered approach that respects individual choices and prioritizes privacy. The organization combines expertise from various fields, including medicine and technology, to deliver evidence-based care and support to those seeking to overcome opioid addiction.

Mori

Series B in 2021
Mori, officially known as Cambridge Crops, Inc., specializes in the development of an innovative biopolymer coating designed to extend the shelf life of perishable foods. Established in 2016 and headquartered in Boston, Massachusetts, the company utilizes a unique process that extracts protein from natural silk using salt and water. This edible and natural coating forms a protective layer over various food items, including fruits, vegetables, meat, and seafood, effectively slowing down spoilage. Through its technology, Mori aims to enhance the freshness of food while promoting sustainability in the food supply chain.

Astranis

Series C in 2021
Astranis Space Technologies Corp. specializes in the manufacturing of small telecommunications satellites designed to enhance Internet connectivity. Founded in 2015 and headquartered in San Francisco, California, the company offers a product known as MicroGEO for geostationary orbit. Astranis is focused on developing innovative satellite technology that enables precise data transmission to specific terrestrial locations. Its primary mission is to provide Internet access to the estimated 4 billion people worldwide who currently lack connectivity.

Orchid

Seed Round in 2021
Orchid is a reproductive technology startup based in San Francisco, California, specializing in detecting rare genetic disorders. The company offers a preconception system that analyzes the genomes of both partners to assess their genetic predispositions to various diseases, including heart disease, stroke, and certain cancers. By utilizing an at-home saliva test, Orchid generates a “Couple Report” that evaluates the likelihood of genetic risks and models potential DNA combinations for future children. In cases of elevated risk, Orchid provides insights to help couples manage health considerations, including dietary adjustments or reproductive options such as in vitro fertilization. Founded by Noor Siddiqui in 2019, Orchid collaborates with experts in reproductive medicine and genetics to deliver accurate results and guidance for prospective parents.

Orchid

Seed Round in 2021
Orchid is a reproductive technology startup based in San Francisco, California, specializing in detecting rare genetic disorders. The company offers a preconception system that analyzes the genomes of both partners to assess their genetic predispositions to various diseases, including heart disease, stroke, and certain cancers. By utilizing an at-home saliva test, Orchid generates a “Couple Report” that evaluates the likelihood of genetic risks and models potential DNA combinations for future children. In cases of elevated risk, Orchid provides insights to help couples manage health considerations, including dietary adjustments or reproductive options such as in vitro fertilization. Founded by Noor Siddiqui in 2019, Orchid collaborates with experts in reproductive medicine and genetics to deliver accurate results and guidance for prospective parents.

Brave Care

Series A in 2021
Brave Care, Inc. is a healthcare provider specializing in urgent pediatric services. Founded in 2017 and based in Portland, Oregon, the company operates clinics that address a variety of childhood illnesses and injuries. Services offered include treatment for allergies, asthma, coughs, ear pain, eye problems, fever, and urinary tract infections. Brave Care also provides care for minor fractures, strains, sprains, and head trauma, along with pediatric-specific laboratory services and on-site x-ray capabilities. The clinics are equipped to perform procedures such as stitches and tissue glue application for wound closure, as well as mild sedation for uncomfortable treatments.

Rubedo

Seed Round in 2020
Rubedo Life Sciences, Inc. is a biopharmaceutical company based in Sunnyvale, California, focused on developing therapies for age-related diseases by targeting senescent cells. Incorporated in 2018, the company utilizes its ALEMBIC drug discovery platform to create a pipeline of therapeutic candidates that selectively eliminate senescent cells, as well as pro-inflammatory and pro-fibrotic cell populations resulting from cellular stress and damage. By promoting selective apoptosis in aged or pathological tissues, Rubedo aims to regenerate tissues, improve the function of healthy cells, and ultimately extend the health span of patients. The company is dedicated to addressing the challenges posed by age-related conditions through innovative therapeutic solutions.

64x Bio

Seed Round in 2020
64x Bio is a biotechnology company based in San Francisco, California, founded in 2017 by Alexis Rovner, George Church, Jeffrey Way, and Pamela Silver. The company specializes in designing microorganisms with enhanced properties to facilitate advanced applications in biomanufacturing, bioremediation, and health. By creating cells tailored for specific purposes, 64x Bio aims to enable innovative solutions that were previously unattainable in these fields.

Curative

Seed Round in 2020
Curative provide communities with 24-hour COVID-19 testing at scale with a significantly more efficient and precise oral fluid test that reduces pressure on medical supply chains and healthcare workers.

ANA Therapeutics

Seed Round in 2020
ANA Therapeutics is a developer of a novel coronavirus vaccine intended to save human lives. It is developing therapeutics to solve the coronavirus pandemic using Niclosamide that enables medical practitioners to treat patients suffering from COVID-19. It was founded in 2020 and is headquartered in Foster City, California.

Mori

Series A in 2020
Mori, officially known as Cambridge Crops, Inc., specializes in the development of an innovative biopolymer coating designed to extend the shelf life of perishable foods. Established in 2016 and headquartered in Boston, Massachusetts, the company utilizes a unique process that extracts protein from natural silk using salt and water. This edible and natural coating forms a protective layer over various food items, including fruits, vegetables, meat, and seafood, effectively slowing down spoilage. Through its technology, Mori aims to enhance the freshness of food while promoting sustainability in the food supply chain.

Magic

Seed Round in 2020
Get peace of mind with secure, extensible passwordless authentication that’s built to scale. All with a few lines of code.

Ophelia

Seed Round in 2020
Ophelia Health, Inc. specializes in medication-assisted treatment for individuals struggling with opioid dependence. The company employs a digital platform to facilitate teleconferenced consultations between patients and licensed clinicians, allowing for convenient access to treatment from home. Ophelia provides not only prescription medications but also therapeutic support, aiming to eliminate the stigma often associated with traditional rehabilitation programs. Founded in 2019 and based in Philadelphia, Pennsylvania, Ophelia emphasizes a patient-centered approach that respects individual choices and prioritizes privacy. The organization combines expertise from various fields, including medicine and technology, to deliver evidence-based care and support to those seeking to overcome opioid addiction.

Knowde

Series A in 2020
knowde is the online marketing platform dedicated to chemicals and ingredients. They make it easy to connect with customers, online. Use knowde Pages to get your products noticed every time a customer searches on any search engine. Build your knowde Page in an hour and get started for free.

Avail Medsystems

Series A in 2020
Avail Medsystems, Inc. is a medical technology company based in Palo Alto, California, focused on enhancing connectivity in healthcare settings through its innovative software platform. This platform allows healthcare experts to remotely support practitioners during medical procedures, facilitating real-time collaboration and clinical education. By digitizing the physical presence typically required in operating rooms, Avail Medsystems aims to democratize access to essential clinical expertise, thereby overcoming physical, economic, and logistical barriers. The company's Procedural Telemedicine solution enables healthcare professionals to connect seamlessly with remote specialists, ensuring that quality care and guidance are always accessible. Founded in 2012 and formerly known as Nurep, Inc., Avail Medsystems has positioned itself at the forefront of integrating technology into medical practices.

Uniform Teeth

Series A in 2019
Uniform Teeth is an orthodontics practice committed to making orthodontic care as intuitive, accessible, and high quality as possible. Uniform Teeth specializes in providing clear straighteners.

Uniform Teeth

Series A in 2019
Uniform Teeth is an orthodontics practice committed to making orthodontic care as intuitive, accessible, and high quality as possible. Uniform Teeth specializes in providing clear straighteners.

Redesign Science

Seed Round in 2019
Redesign Science Inc is a biotechnology company based in New York, established in 2017, that specializes in small molecule drug discovery. The company employs advanced techniques, including first-principles physics and artificial intelligence, to simulate protein targets at the atomic level. This approach allows Redesign Science to identify subtle drug opportunities that conventional computational models may overlook. By focusing on the development of first-in-class small molecules, the company aims to address emerging and challenging targets associated with significant unmet medical needs. Their innovative methodologies not only enhance the understanding of biological pathways and disease mechanisms but also drive the commercialization of new therapeutic solutions.

Tempest

Series A in 2019
Tempest, Inc. operates an online recovery school that offers a virtual course for people wanting to quit alcohol. It also offers email courses. It offers tools to help participants learn the importance of purpose, meaning, and creativity in living a life without alcohol. Tempest, Inc. was formerly known as Hip Sobriety, Inc. and changed its name to Tempest, Inc. in May 2019. The company founded in 2014 and is based in New York, New York.

Brave Care

Seed Round in 2019
Brave Care, Inc. is a healthcare provider specializing in urgent pediatric services. Founded in 2017 and based in Portland, Oregon, the company operates clinics that address a variety of childhood illnesses and injuries. Services offered include treatment for allergies, asthma, coughs, ear pain, eye problems, fever, and urinary tract infections. Brave Care also provides care for minor fractures, strains, sprains, and head trauma, along with pediatric-specific laboratory services and on-site x-ray capabilities. The clinics are equipped to perform procedures such as stitches and tissue glue application for wound closure, as well as mild sedation for uncomfortable treatments.

Mori

Seed Round in 2019
Mori, officially known as Cambridge Crops, Inc., specializes in the development of an innovative biopolymer coating designed to extend the shelf life of perishable foods. Established in 2016 and headquartered in Boston, Massachusetts, the company utilizes a unique process that extracts protein from natural silk using salt and water. This edible and natural coating forms a protective layer over various food items, including fruits, vegetables, meat, and seafood, effectively slowing down spoilage. Through its technology, Mori aims to enhance the freshness of food while promoting sustainability in the food supply chain.

Umbrella

Seed Round in 2019
Umbrella, Inc. is a Brooklyn-based company that offers home maintenance services on a membership basis, catering primarily to senior citizens. Founded in 1995, the company provides a range of services designed to assist with everyday home chores and maintenance. These services include home repair, seasonal tasks, plumbing, and cleaning, along with specific tasks such as carpentry, light fixture changes, and air conditioner installation. Umbrella's task management platform connects seniors with community members who can perform small, temporary jobs, thereby enabling older adults to maintain their independence and continue living comfortably in their own homes.

Solugen

Series B in 2019
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

Kin Euphorics

Venture Round in 2019
Kin Euphorics is a New York-based company, founded in 2017, that specializes in non-alcoholic beverages designed to enhance social experiences. The company's offerings include ready-to-drink tonics made from a combination of nootropics, adaptogens, and botanicals. These functional beverages aim to promote a sense of focused relaxation, helping consumers unwind without inducing sleepiness or compromising cognitive function. Kin Euphorics targets individuals seeking a balanced and nourishing alternative to traditional alcoholic drinks, allowing them to enjoy social interactions while supporting their mental well-being.

Vital

Seed Round in 2019
Vital Software Inc. is a provider of cloud-based software specifically designed for emergency departments in hospitals. Founded in 2017 and headquartered in Atlanta, Georgia, the company focuses on enhancing patient experiences and optimizing operational flow within emergency rooms. Its software leverages artificial intelligence to predict patient admissions and offers real-time updates regarding patients' next steps and estimated wait times. This technology allows clinicians to spend less time on electronic health records and ensures seamless communication with patients and their families, ultimately improving efficiency and potentially reducing costs for healthcare facilities.

Culture Biosciences

Venture Round in 2019
Culture Biosciences, founded in 2016 and headquartered in San Francisco, California, specializes in developing automated bioreactors and tools for fermentation. The company provides a digital bio-manufacturing platform that allows biotech companies to optimize their manufacturing processes, enabling them to bring products to market more efficiently. By utilizing robotic sample handling and cloud-based data monitoring and analysis, Culture Biosciences helps scientists run, monitor, and analyze bioreactors more quickly than traditional methods. This innovative approach supports the biotechnology sector in enhancing productivity and streamlining workflows.

AKASA

Seed Round in 2019
Alpha Health LLC specializes in developing a unified automation platform for healthcare revenue cycle management, aimed at reducing the cost of care for health systems. Founded in 2018 and based in South San Francisco, California, the company leverages advanced machine learning techniques to streamline complex medical reimbursement processes. Its platform captures multimodal data to offer a comprehensive view of existing workflows, identifying and correcting inefficiencies to eliminate unnecessary tasks. By integrating human expertise with data and technology, Alpha Health enhances the efficiency and accuracy of revenue management, enabling healthcare providers to be more effective stewards of healthcare resources.

Cambridge Cancer Genomics

Seed Round in 2018
Cambridge Cancer Genomics Limited offers diagnostics tests for cancer patients using liquid biopsy, artificial intelligence, and genomics. It uses artificial neural networks and machine learning algorithms to design personalized tests for tracking treatment response in patients. The company enables cancer clinics, academic institutes, biotech startups, and pharmaceutical companies to make use of the tools and therapies. Cambridge Cancer Genomics Limited was incorporated in 2017 and is based in Cambridge, United Kingdom.

Knowde

Seed Round in 2018
knowde is the online marketing platform dedicated to chemicals and ingredients. They make it easy to connect with customers, online. Use knowde Pages to get your products noticed every time a customer searches on any search engine. Build your knowde Page in an hour and get started for free.

Solugen

Series A in 2018
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

Hero Health

Series A in 2018
Hero Health, Inc. specializes in developing innovative in-home medication management solutions aimed at improving patient adherence and simplifying the medication process. Founded in 2018 and headquartered in New York, the company offers the Hero device, a secure countertop unit that sorts, dispenses, tracks, and reminds users of their medications while automating refill orders based on needs. Complementing this device is the Hero application, which helps manage medication regimens, and Hero Fill, a service that facilitates prescription delivery. By providing real-time and historical adherence data, Hero Health seeks to enhance the healthcare experience for both patients and caregivers, addressing common challenges in medication management.

Blockfolio

Series A in 2018
Blockfolio, Inc. is a mobile application designed for cryptocurrency portfolio tracking and management, catering to the needs of the cryptocurrency and blockchain industry. Founded in 2014 and based in Marina Del Rey, California, the app enables users to manage their cryptocurrency holdings by providing real-time prices, market data, and updates from various projects. Users can also automate their portfolio tracking by linking the application to their exchange accounts, making it easier to monitor market movements and stay informed about relevant news. As of August 2020, Blockfolio operates as a subsidiary of FTX Trading LTD and has gained the trust of millions who rely on the platform for comprehensive insights into the evolving cryptocurrency landscape.

FactoryFour

Series A in 2018
FactoryFour is a software company based in Baltimore, Maryland, founded in 2015, specializing in manufacturing execution systems (MES). Its solutions are designed to manage and automate manufacturing processes, particularly in the realm of digital fabrication, making it a viable service for mass manufacturing. The company's cloud-based software offers highly customizable and user-friendly tools that enhance productivity and profitability by providing real-time data on manufacturing operations. This enables clients to effectively plan production, prioritize orders, and automate scheduling with adaptable logic tailored to their specific needs. By facilitating the capture and analysis of operational data, FactoryFour empowers businesses to improve their manufacturing efficiency and decision-making capabilities.

Checkerspot

Seed Round in 2018
Checkerspot, Inc. is a biotech company based in Berkeley, California, founded in 2016. It specializes in producing performance materials derived from microalgae, leveraging advances in biology, chemistry, and materials science. The company aims to revolutionize material design by utilizing a technology platform that allows for molecular-level customization of new materials. Through a process of applications development, Checkerspot prototypes and refines products to meet specific needs, engaging directly with users and partnering with socially responsible corporations. This approach enables them to create superior materials tailored for various applications, enhancing the capabilities available to product designers.

Shield Bio

Series A in 2018
At Shield, we’re ensuring that antibiotic resistance doesn’t become more deadly than cancer. In 2050 more people will be dying of antibiotic resistant pathogens than cancer. Infections that were once treatable with a simple oral antibiotics are now requiring complex, painful treatments and resulting in serious health complications for patients. Gonorrhea is one such infection, having become resistant to over 10 different antibiotics, they have only one treatment that is still effective and resistance to this has already begun to emerge. With 820,000 new infections every year in the US, antibiotic resistance will spread quickly, which is why the CDC has resistant gonorrhea at an urgent threat level, the highest level available. Shield's novel genomic testing platform enables STI clinics to identify the antibiotic resistant strains of gonorrhea and other pathogens that their patients have, so they can select the correct antibiotics and halt the spread of antibiotic resistance.

Biobot Analytics

Seed Round in 2018
Biobot Analytics, Inc. is a wastewater epidemiology company based in Cambridge, Massachusetts, founded in 2017. The company specializes in transforming sewer systems into public health observatories through innovative technology that analyzes wastewater samples. By deploying proprietary sampling devices and spatial analytics, Biobot measures various health threats, including infectious disease outbreaks, antibiotic resistance, and fluctuations in drug consumption. One of its key initiatives is the Opioid Consumption Monitoring Program, which assesses opioid usage by analyzing sewage to provide estimates of drug consumption in urban areas. This approach creates a health database that operates independently of traditional hospital reporting systems, enabling rapid adaptation to emerging public health challenges while minimizing societal biases in healthcare access.

Astranis

Series A in 2018
Astranis Space Technologies Corp. specializes in the manufacturing of small telecommunications satellites designed to enhance Internet connectivity. Founded in 2015 and headquartered in San Francisco, California, the company offers a product known as MicroGEO for geostationary orbit. Astranis is focused on developing innovative satellite technology that enables precise data transmission to specific terrestrial locations. Its primary mission is to provide Internet access to the estimated 4 billion people worldwide who currently lack connectivity.

Uniform Teeth

Seed Round in 2018
Uniform Teeth is an orthodontics practice committed to making orthodontic care as intuitive, accessible, and high quality as possible. Uniform Teeth specializes in providing clear straighteners.

PathAI

Series A in 2017
PathAI, Inc. develops artificial intelligence-based technology solutions for pathology laboratories. It develops a technology that assists pathologists in making rapid and accurate diagnoses for patients. The company also builds solutions to help identify patients that benefit from novel therapies, to make scalable personalized medicine a reality. PathAI, Inc. was founded in 2016 and is based in Boston, Massachusetts with an additional office in Austin, Texas.

Solugen

Seed Round in 2017
Solugen, Inc. is a specialty chemicals manufacturer based in Houston, Texas, founded in 2016. The company utilizes industrial biotechnology and green chemistry to produce a range of eco-friendly industrial chemicals. Its product offerings include BioPeroxide, a carbon-negative hydrogen peroxide; BioChelate, a biodegradable chelant; ScavSol, a multivalent metal sequestrant for energy applications; ScaleSol, a scale control alternative to phosphonates; and CorrSol, designed for corrosion and fouling control. Solugen focuses on creating safe, cost-effective, and environmentally-friendly solutions, serving various sectors such as agriculture, cleaning, energy, and water. The company employs a patented method that leverages bio-inspired reactions and plant materials as low-cost feedstocks, enabling it to produce innovative products that are competitively priced in the market.

Octant Bio

Seed Round in 2017
Octant, Inc. engages in engineering biology to design multi-targeted small molecule drug leads for complex diseases. Its polypharmacology discovery engine generates multi-receptor pathway data and predictive insights to inform rational drug design. The company also engineers biology using living cells as high-throughput signal networks to map, measure, and model chemical structures against G protein-coupled receptors (GPCRs). The company was incorporated in 2017 and is headquartered in Los Angeles, California.

Enzyme

Seed Round in 2017
Enzyme is building software to help life sciences companies with FDA approval and regulatory compliance. Using Enzyme’s software, those companies can avoid spending money on costly consultants which in turn can reduce their compliance costs by up to 50 percent. Since 10 percent of all personnel in biopharma and life sciences companies are related to regulatory issues, it can lower headcount as well. Perhaps most importantly, Enzyme can also make it easier and faster for those companies to bring their products to market.

Cofactor Genomics

Series A in 2017
Cofactor Genomics is a Predictive Immune Modeling company driven to remove the barriers that have prohibited the advancement of true precision medicine. Cofactor is enabling the industry to move beyond isolated, single-analyte biomarkers to powerful multidimensional biomarkers using Health Expression Models. Through their molecular, informatic, and database tools, and one of the first CAP-certified, clinical RNA sequencing laboratories, Cofactor enables their partners to deliver more expedient, cost effective, and successful clinical trials.

Knowde

Pre Seed Round in 2017
knowde is the online marketing platform dedicated to chemicals and ingredients. They make it easy to connect with customers, online. Use knowde Pages to get your products noticed every time a customer searches on any search engine. Build your knowde Page in an hour and get started for free.

Call9

Series B in 2017
Call9, Inc. offers a mobile technology platform designed to connect patients in skilled nursing facilities with emergency physicians. The company's flagship service, the Call9 tele-EM platform, allows nursing home staff to activate on-site Clinical Care Specialists when a patient experiences an acute medical event, eliminating the need to call 911. Within moments, these specialists are at the patient’s bedside and are linked to board-certified emergency medicine physicians through Call9’s proprietary technology. This innovative approach facilitates expedited treatment and point-of-care testing, enabling over 80% of patients to remain in their nursing home beds during emergencies. By reducing unnecessary hospital transfers, Call9 not only enhances patient care but also contributes to significant cost savings for the healthcare system and taxpayers. Founded in 2015, the company is headquartered in Brooklyn, New York.

Gencove

Seed Round in 2017
We make genomics affordable and accessible through a cost-effective low-coverage whole genome sequencing technology

Clover Health

Series D in 2017
Clover Health is a health insurance company that provides Medicare Advantage plans primarily for senior citizens in New Jersey, and it also serves members in several other states, including Arizona, Georgia, Pennsylvania, South Carolina, Tennessee, and Texas. Founded in 2014 and based in San Francisco, Clover Health operates a Preferred Provider Organization (PPO) platform aimed at enhancing the quality of life for its members. The company focuses on preventive care through patient-centered analytics and a dedicated care management team, which helps identify potential health risks and manage chronic diseases. By employing advanced analytics and custom software, Clover Health directs its clinical staff to address care gaps, ultimately aiming to reduce unnecessary healthcare costs while improving health outcomes for its members.

Plutoshift

Seed Round in 2017
Plutoshift is an operational data platform to monitor physical infrastructure. It leverages existing data collection systems to automate data workflows and provide a unified view of performance. It was founded in 2017 and headquartered in Palo Alto, California.

TL Biolabs

Seed Round in 2017
TL Biolabs Corp. is a biotechnology company based in Santa Clara, California, that specializes in automated genomic testing for livestock. Established in 2016, the company focuses on providing cost-effective genomic tests specifically for beef and dairy cattle. In addition to its testing services, TL Biolabs offers complimentary software designed to deliver actionable results, enhancing decision-making for livestock management.

Shield Bio

Seed Round in 2017
At Shield, we’re ensuring that antibiotic resistance doesn’t become more deadly than cancer. In 2050 more people will be dying of antibiotic resistant pathogens than cancer. Infections that were once treatable with a simple oral antibiotics are now requiring complex, painful treatments and resulting in serious health complications for patients. Gonorrhea is one such infection, having become resistant to over 10 different antibiotics, they have only one treatment that is still effective and resistance to this has already begun to emerge. With 820,000 new infections every year in the US, antibiotic resistance will spread quickly, which is why the CDC has resistant gonorrhea at an urgent threat level, the highest level available. Shield's novel genomic testing platform enables STI clinics to identify the antibiotic resistant strains of gonorrhea and other pathogens that their patients have, so they can select the correct antibiotics and halt the spread of antibiotic resistance.

PathAI

Seed Round in 2016
PathAI, Inc. develops artificial intelligence-based technology solutions for pathology laboratories. It develops a technology that assists pathologists in making rapid and accurate diagnoses for patients. The company also builds solutions to help identify patients that benefit from novel therapies, to make scalable personalized medicine a reality. PathAI, Inc. was founded in 2016 and is based in Boston, Massachusetts with an additional office in Austin, Texas.

PathAI

Seed Round in 2016
PathAI, Inc. develops artificial intelligence-based technology solutions for pathology laboratories. It develops a technology that assists pathologists in making rapid and accurate diagnoses for patients. The company also builds solutions to help identify patients that benefit from novel therapies, to make scalable personalized medicine a reality. PathAI, Inc. was founded in 2016 and is based in Boston, Massachusetts with an additional office in Austin, Texas.

Legalist

Seed Round in 2016
Legalist provides legal data analytics services designed to help small business to get access to the justice system. Its services help lawyers to track state trial cases, get e-mail alerts for cases and predict trial timelines before cases start, enabling plaintiffs and their attorneys to tackle legal situations and complications in a convenient and hassle-free manner.

Finova Financial

Venture Round in 2016
Finova Financial LLC develops and operates digital financial services technology platform, provides consumer loan on cars. The company was founded in 2015 and is based in Palm Beach Gardens, Florida.

Trace Genomics

Seed Round in 2016
Trace Genomics, Inc. specializes in developing artificial intelligence-based diagnostic tools for farmers, focusing on soil health and crop quality. The company offers a soil microbiome test that utilizes DNA sequencing and artificial intelligence to analyze microbial species in agricultural soils. By interpreting key indicators of soil health and disease risk, Trace Genomics enables early predictions of soil diseases, benefiting agronomists and their corporate partners. Founded in 2015 and headquartered in Burlingame, California, with an additional office in Ames, Iowa, Trace Genomics aims to enhance agricultural practices and maximize the value of every acre for the farming community.

Clover Health

Series C in 2016
Clover Health is a health insurance company that provides Medicare Advantage plans primarily for senior citizens in New Jersey, and it also serves members in several other states, including Arizona, Georgia, Pennsylvania, South Carolina, Tennessee, and Texas. Founded in 2014 and based in San Francisco, Clover Health operates a Preferred Provider Organization (PPO) platform aimed at enhancing the quality of life for its members. The company focuses on preventive care through patient-centered analytics and a dedicated care management team, which helps identify potential health risks and manage chronic diseases. By employing advanced analytics and custom software, Clover Health directs its clinical staff to address care gaps, ultimately aiming to reduce unnecessary healthcare costs while improving health outcomes for its members.

Astranis

Seed Round in 2016
Astranis Space Technologies Corp. specializes in the manufacturing of small telecommunications satellites designed to enhance Internet connectivity. Founded in 2015 and headquartered in San Francisco, California, the company offers a product known as MicroGEO for geostationary orbit. Astranis is focused on developing innovative satellite technology that enables precise data transmission to specific terrestrial locations. Its primary mission is to provide Internet access to the estimated 4 billion people worldwide who currently lack connectivity.

Kip

Seed Round in 2016
Kip Labs, Inc. is a San Francisco-based company founded in 2015 that specializes in enhancing the therapeutic process through a digital application. The app facilitates online communication between patients and therapists, allowing users to track their progress, develop positive habits, and exchange messages and notes outside of scheduled appointments. By integrating traditional in-person therapy with a private digital platform, Kip aims to optimize therapeutic outcomes. Clients can engage directly with their therapists to create personalized care plans and share daily reflections, fostering a more effective therapeutic experience. The company serves areas including San Francisco, East Bay, and Silicon Valley, emphasizing a science-backed approach to mental health support.

Alloy.ai

Seed Round in 2016
Alloy is a purpose-built platform enabling consumer goods companies to evaluate, predict, and respond to true demand with agility and efficiency. With Alloy, brands can analyze sales and inventory at both macro and micro levels, down to the individual store and SKU, to accelerate sales insights, drive future growth, and optimize the supply chain. A breadth of customers have benefited from the end-to-end insight into their business, ranging from Fortune 100 enterprises to fast-growing startups like eero, Walker & Company, and Soludos.

Finova Financial

Seed Round in 2016
Finova Financial LLC develops and operates digital financial services technology platform, provides consumer loan on cars. The company was founded in 2015 and is based in Palm Beach Gardens, Florida.

Call9

Series A in 2016
Call9, Inc. offers a mobile technology platform designed to connect patients in skilled nursing facilities with emergency physicians. The company's flagship service, the Call9 tele-EM platform, allows nursing home staff to activate on-site Clinical Care Specialists when a patient experiences an acute medical event, eliminating the need to call 911. Within moments, these specialists are at the patient’s bedside and are linked to board-certified emergency medicine physicians through Call9’s proprietary technology. This innovative approach facilitates expedited treatment and point-of-care testing, enabling over 80% of patients to remain in their nursing home beds during emergencies. By reducing unnecessary hospital transfers, Call9 not only enhances patient care but also contributes to significant cost savings for the healthcare system and taxpayers. Founded in 2015, the company is headquartered in Brooklyn, New York.

Verge Genomics

Seed Round in 2015
Verge Genomics focuses on accelerating drug discovery for neurodegenerative diseases through the use of artificial intelligence and genomic data. The company has developed a platform that leverages machine learning to analyze large datasets, identifying genetic targets and predicting effective therapeutics. By mapping genes associated with various neurodegenerative conditions, Verge aims to discover drugs that can simultaneously target multiple genetic factors. Founded by experts in machine learning and neuroscience, Verge Genomics seeks to improve patient outcomes and reduce the costs associated with pharmaceutical development. The company is based in Mountain View, California, and has formed a strategic alliance with Datavant to enhance its data-driven approach.

Headspace

Series A in 2015
Headspace is a digital health platform established in 2010 and headquartered in Santa Monica, California, that specializes in guided meditation and mindfulness training. It offers a vast library of content, recognized as one of the most comprehensive secular programs in this field, accessible via mobile and tablet applications. Users can engage in mindfulness practices through various features, including health videos and chat options, which also facilitate access to free meditation sessions. Headspace Health, an extension of the brand, focuses on mental health and well-being, partnering with over 2,500 companies and health plans to provide services that include meditation, mindfulness, coaching, therapy, and psychiatry. Notable partners include major organizations such as Starbucks, Adobe, Delta Air Lines, ViacomCBS, Cigna, and Kaiser Permanente.

PicnicHealth

Seed Round in 2015
PicnicHealth is all about making medical records easy to access and using data to power the next frontier of medical research. We’re led by the belief that there’s power in medical information when it’s used well, and that every person has a right to their own theirs. And we've built award-winning machine learning to do it. How? PicnicHealth works directly with patients to give them the only tool anywhere that truly provides all of their medical records from any doctor or healthcare system in the US—in an easy-to-use, secure online dashboard. Not only that, but patients can choose to contribute their data to scientific research, which helps life sciences researchers accelerate breakthroughs in care. Researchers use this anonymized “real-world data” to understand how diseases are experienced by patients and treated by clinicians in the real world, going beyond the highly controlled setting of clinical trials. The goal is to create better treatments that can ultimately improve outcomes for patients. Whether you’re a scientist, engineer, or patient yourself, we’re looking for passionate people to join us in redefining an industry during our next stage of growth. To date we’ve helped tens of thousands of patients, partnered with some of the world’s largest biopharma companies, and raised more than $35M from Felicis Ventures, Amplify Partners, Foresite Capital, Refactor Capital, and Y Combinator.
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