Wireframe Ventures

Wireframe Ventures is a venture capital firm founded in 2016 and based in San Francisco, California. The firm specializes in seed and pre-seed stage investments, focusing on technology-driven companies that aim to create a positive impact on society and the environment. Wireframe Ventures seeks to support innovative founders across various sectors, including information technology, robotics, diagnostics, and energy. Through its investment strategy, the firm aims to back early-stage companies that demonstrate potential for significant growth and transformative contributions to their respective industries.

Lily Bernicker

Principal

Harsh Patel

Co-Founder and Managing Director

Paul Straub

Managing Partner and Co-Founder

31 past transactions

Tembo

Seed Round in 2023
Dev-first, fully-extensible managed Postgres.

Tyba

Seed Round in 2023
Tyba provides end-to-end modeling of standalone and hybrid storage projects from early-stage development through operations, giving your business the edge to build and operate the best projects faster and more profitably.

Arise

Seed Round in 2022
Eating disorders affect people of all backgrounds, identities, and experiences, yet up to 90% won't get care. Arise aims to change that, breaking down barriers and stigma and expanding access to inclusive care through virtual treatment pathways, community, and ongoing support.

Endpoint Health

Series A in 2022
Endpoint Health, Inc. researches and develops therapies by combining therapeutics, companion diagnostics, and artificial intelligence into an integrated platform. It develops therapies to improve the outcomes of patients with critical illnesses, such as sepsis, acute respiratory distress syndrome, and COVID-19. Endpoint Health, Inc. was founded in 2018 and is headquartered in Palo Alto, California. It has additional offices in Detroit and Livonia, Michigan; and Chicago, Illinois.

Recurrent

Venture Round in 2022
Recurrent Motors, Inc. engages in analyzing and providing reports for electric vehicle (EV) batteries. It offers car dealers and private party buyers with vehicle reports to buy used electric cars; and owners with personalized monthly battery analysis of their EVs. The company was founded in 2020 and is based in Seattle, Washington.

Solo AVT

Seed Round in 2022
Solo AVT engages in revolutionizing the heavy truck industry.

Phytoform Labs

Seed Round in 2021
Phytoform Labs is a biotechnology company which aims to help breeders to cut down plant breeding times from decades to years using new gene editing technologies. Predictably evolving plants will maximise yields for breeders and improve the economics of breeding for customers.

Near Space Labs

Series A in 2021
Near Space Labs is an aerial imagery and earth observation company, Near Space Labs' imagery makes it easy to monitor assets and gain remote access over broad or specific areas. Near Space Labs offers cloud-based delivery of fully processed images through its API. The company provides frictionless, affordable imaging for insurance, utilities, infrastructure, conservation, smart cities, retail, energy, government, and disaster response.

LevelTen Energy

Series C in 2021
LevelTen Energy, Inc. operates a renewable energy transaction marketplace that links corporate and industrial power buyers with power purchase agreements (PPAs) from utility-scale wind, solar, and storage projects. Founded in 2016 and based in Seattle, Washington, the company provides a technology-driven platform that enables a diverse range of customers to access renewable energy solutions. By aggregating buyers and sellers, LevelTen allows smaller corporate and industrial customers to engage with the same projects and terms typically available to larger energy purchasers. This innovative approach simplifies the procurement process, helping customers achieve their sustainability goals while stabilizing energy costs and eliminating the complexities of traditional request for proposal (RFP) processes.

Enveda Biosciences

Series A in 2021
Enveda Therapeutics is constructing and decoding the largest integrated dataset of anthropological, biological, and chemical information from medicinal plants to inspire new medicines.

Gridware

Seed Round in 2021
Gridware provides a grid monitoring system of sensors and software for the power distribution grid. The system centers around a low-cost hardware platform that is easily and permanently deployed to power poles. The platform detects and predicts faults that ignite wildfires, expedites repairs during a power outage, and helps utilities demonstrate risk reduction to regulators through comprehensive asset health profiles.

Recurrent

Seed Round in 2020
Recurrent Motors, Inc. engages in analyzing and providing reports for electric vehicle (EV) batteries. It offers car dealers and private party buyers with vehicle reports to buy used electric cars; and owners with personalized monthly battery analysis of their EVs. The company was founded in 2020 and is based in Seattle, Washington.

MycoWorks

Series B in 2020
MycoWorks LLC specializes in the research, design, and manufacturing of sustainable leather alternatives derived from natural mycelium. Established in 2013 and based in San Francisco, the company produces a proprietary material called Reishi, which is water-resistant and customizable in texture and features. Reishi is designed to mimic the performance and feel of traditional leather while being animal-free and environmentally friendly. MycoWorks employs a unique platform known as Fine Mycelium to create this innovative biomaterial, which boasts qualities such as strength, durability, and biodegradability. The company aims to provide natural alternatives to conventional materials like plastic foams, textiles, and leather, catering to industries such as aerospace, automotive, apparel, and architectural interiors. Through its carbon-negative production process, MycoWorks offers a rapidly grown solution that aligns with sustainable design principles.

Enveda Biosciences

Seed Round in 2020
Enveda Therapeutics is constructing and decoding the largest integrated dataset of anthropological, biological, and chemical information from medicinal plants to inspire new medicines.

Endpoint Health

Venture Round in 2020
Endpoint Health, Inc. researches and develops therapies by combining therapeutics, companion diagnostics, and artificial intelligence into an integrated platform. It develops therapies to improve the outcomes of patients with critical illnesses, such as sepsis, acute respiratory distress syndrome, and COVID-19. Endpoint Health, Inc. was founded in 2018 and is headquartered in Palo Alto, California. It has additional offices in Detroit and Livonia, Michigan; and Chicago, Illinois.

Span

Series A in 2020
Span.IO, Inc. specializes in renewable energy products for residential use, focusing on smart electrical panels that serve as the central hub for managing home energy. Founded in 2018 and headquartered in San Francisco, the company also offers an application called The Span, which allows homeowners to monitor and control their energy consumption remotely, schedule usage, and receive alerts. Span.IO aims to facilitate the transition to clean energy through innovative technology that enhances user experience while promoting sustainability. The company collaborates with installers, technology providers, and energy companies to reach homeowners and is driven by a team of engineers committed to creating impactful solutions in the energy sector.

MycoWorks

Series A in 2020
MycoWorks LLC specializes in the research, design, and manufacturing of sustainable leather alternatives derived from natural mycelium. Established in 2013 and based in San Francisco, the company produces a proprietary material called Reishi, which is water-resistant and customizable in texture and features. Reishi is designed to mimic the performance and feel of traditional leather while being animal-free and environmentally friendly. MycoWorks employs a unique platform known as Fine Mycelium to create this innovative biomaterial, which boasts qualities such as strength, durability, and biodegradability. The company aims to provide natural alternatives to conventional materials like plastic foams, textiles, and leather, catering to industries such as aerospace, automotive, apparel, and architectural interiors. Through its carbon-negative production process, MycoWorks offers a rapidly grown solution that aligns with sustainable design principles.

Electriphi

Seed Round in 2020
Electriphi, Inc. is a company that specializes in developing an online platform and mobile application for managing the transition from conventional vehicle fleets to electric ones. Founded in 2018 and based in San Francisco, California, with an additional office in San Jose, Electriphi provides a comprehensive suite of tools for fleet managers, energy utilities, and planning teams. Their Fleet Electrification Planning Tool offers energy cost analysis, infrastructure assessments, and evaluations of environmental impacts tailored to the specific characteristics of various fleets, including electric transit buses, school buses, and delivery vehicles. The company focuses on optimizing energy costs and enhancing operational readiness through its managed charging software, which incorporates artificial intelligence and machine learning technologies.

Astronomer

Seed Round in 2019
Astronomer, Inc., founded in 2014 and based in Cincinnati, Ohio, provides a managed platform for Apache Airflow, catering specifically to data engineers. The company focuses on enabling organizations to harness the capabilities of Apache Airflow through its flagship offering, Astronomer Cloud, which is recognized as a leading Airflow-as-a-Service solution. Astronomer is dedicated to enhancing standards of scale, performance, and reliability for enterprise-level data orchestration. Its platform encompasses a comprehensive suite of products and services that facilitate the deployment, management, and scaling of data pipelines. This includes features for isolated resource allocation, user access, and account management, allowing data engineers, scientists, and analysts to efficiently build, run, and monitor pipelines-as-code for effective business analytics.

MODit 3D Inc.

Seed Round in 2019
MODit provides smart, automated quality control for manufacturing. MODit's mass-deployable 3D scanning systems and cloud platform increase yields and streamline quality communication across the supply chain.

LevelTen Energy

Series B in 2019
LevelTen Energy, Inc. operates a renewable energy transaction marketplace that links corporate and industrial power buyers with power purchase agreements (PPAs) from utility-scale wind, solar, and storage projects. Founded in 2016 and based in Seattle, Washington, the company provides a technology-driven platform that enables a diverse range of customers to access renewable energy solutions. By aggregating buyers and sellers, LevelTen allows smaller corporate and industrial customers to engage with the same projects and terms typically available to larger energy purchasers. This innovative approach simplifies the procurement process, helping customers achieve their sustainability goals while stabilizing energy costs and eliminating the complexities of traditional request for proposal (RFP) processes.

Span

Seed Round in 2018
Span.IO, Inc. specializes in renewable energy products for residential use, focusing on smart electrical panels that serve as the central hub for managing home energy. Founded in 2018 and headquartered in San Francisco, the company also offers an application called The Span, which allows homeowners to monitor and control their energy consumption remotely, schedule usage, and receive alerts. Span.IO aims to facilitate the transition to clean energy through innovative technology that enhances user experience while promoting sustainability. The company collaborates with installers, technology providers, and energy companies to reach homeowners and is driven by a team of engineers committed to creating impactful solutions in the energy sector.

Full Harvest

Series A in 2018
Full Harvest Technologies, Inc. operates a business-to-business platform that connects large farms with food companies, facilitating the sale of surplus and imperfect produce. Established in 2016 and based in San Francisco, the company addresses the significant issue of food waste in the United States, where approximately 20 billion pounds of produce are discarded annually due to strict retailer standards regarding appearance. By creating a marketplace for this unutilized yet perfectly edible produce, Full Harvest aims to provide farmers with an additional revenue stream while helping food businesses reduce costs. The platform utilizes proprietary technology and an innovative supply chain model to enhance sustainability in the food system, ultimately benefiting both producers and consumers by minimizing waste and promoting the availability of affordable, healthy food options.

OpenInvest

Series A in 2018
OpenInvest is a Public Benefit Corporation and asset manager that uses technology to mainstream customized ethical investing. OpenInvest is a YCombinator and Andreessen Horowitz-backed startup powering the post-fund future. Their team of senior technologists from the hedge fund industry and civil society leaders is first tackling under-served markets in customized ESG asset management. With seed funding, the team has built fully integrated and proprietary direct-indexing construction, management, trading, proxy voting, and UX systems that now serve thousands of customers. Founded in 2015, the company is headquartered in San Francisco, California, United States.

LevelTen Energy

Series A in 2017
LevelTen Energy, Inc. operates a renewable energy transaction marketplace that links corporate and industrial power buyers with power purchase agreements (PPAs) from utility-scale wind, solar, and storage projects. Founded in 2016 and based in Seattle, Washington, the company provides a technology-driven platform that enables a diverse range of customers to access renewable energy solutions. By aggregating buyers and sellers, LevelTen allows smaller corporate and industrial customers to engage with the same projects and terms typically available to larger energy purchasers. This innovative approach simplifies the procurement process, helping customers achieve their sustainability goals while stabilizing energy costs and eliminating the complexities of traditional request for proposal (RFP) processes.

Mammoth Biosciences

Seed Round in 2017
Mammoth Biosciences, Inc. is a biotechnology company based in South San Francisco, California, founded in 2017. It specializes in developing advanced CRISPR solutions, including its proprietary DETECTR technology, which allows for the detection of specific nucleic acids in samples, aiding in diagnostics for various conditions such as bacterial infections, cancer, and viral infections. The company focuses on democratizing disease detection through accessible point-of-care tests that can simultaneously identify multiple health issues. Additionally, Mammoth offers CRISPR-Cas systems for genome editing, targeting therapeutic applications in immuno-oncology, autoimmune diseases, and liver diseases. Its innovative solutions are utilized across diverse sectors, including healthcare, agriculture, environmental monitoring, and biodefense. Co-founded by CRISPR pioneer Jennifer Doudna, Mammoth Biosciences is supported by notable institutional and individual investors, reflecting its commitment to harnessing CRISPR technology for significant advancements in life sciences.

OpenInvest

Seed Round in 2017
OpenInvest is a Public Benefit Corporation and asset manager that uses technology to mainstream customized ethical investing. OpenInvest is a YCombinator and Andreessen Horowitz-backed startup powering the post-fund future. Their team of senior technologists from the hedge fund industry and civil society leaders is first tackling under-served markets in customized ESG asset management. With seed funding, the team has built fully integrated and proprietary direct-indexing construction, management, trading, proxy voting, and UX systems that now serve thousands of customers. Founded in 2015, the company is headquartered in San Francisco, California, United States.

Full Harvest

Seed Round in 2017
Full Harvest Technologies, Inc. operates a business-to-business platform that connects large farms with food companies, facilitating the sale of surplus and imperfect produce. Established in 2016 and based in San Francisco, the company addresses the significant issue of food waste in the United States, where approximately 20 billion pounds of produce are discarded annually due to strict retailer standards regarding appearance. By creating a marketplace for this unutilized yet perfectly edible produce, Full Harvest aims to provide farmers with an additional revenue stream while helping food businesses reduce costs. The platform utilizes proprietary technology and an innovative supply chain model to enhance sustainability in the food system, ultimately benefiting both producers and consumers by minimizing waste and promoting the availability of affordable, healthy food options.

Geneticure

Seed Round in 2016
Geneticure Inc. is a pharmacogenetic testing company focused on developing personalized medicine solutions for patients with hypertension. Founded in 2012 and based in Eden Prairie, Minnesota, the company offers a non-invasive genetic test that analyzes DNA from a cheek swab to identify genetic variants related to the renal, vascular, and cardiac systems. This information helps clinicians determine the most effective treatment options tailored to individual patients based on their unique genetic profiles. Geneticure's testing process includes DNA extraction, genotyping, and the provision of genetic results directly to healthcare providers, accompanied by a decision tree that prioritizes functional genes. This personalized approach aims to optimize blood pressure therapy and improve patient outcomes. Additionally, Geneticure is working on two more pharmacogenomic panels to expand its offerings in personalized medicine.
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