Safeguard Scientifics

Safeguard Scientifics, founded in 1953 and based in Radnor, Pennsylvania, is a private equity and venture capital firm that specializes in providing growth capital to technology companies, particularly in the healthcare, financial services, and digital media sectors. The firm focuses on expansion financings, management buyouts, and early to growth-stage investments, typically ranging from $5 million to $25 million. Safeguard seeks opportunities in companies that possess proprietary technology and intellectual property, preferring to be a significant shareholder, often holding between 20 percent and 50 percent of ownership. The firm primarily invests across the United States, with a concentration in the Mid-Atlantic region and Southeastern Canada. Its portfolio includes investments in areas such as software as a service, artificial intelligence, molecular diagnostics, and digital health, reflecting a commitment to fostering innovation and supporting entrepreneurs in building sustainable market leaders.

Caleb Bank

Senior Venture Capital Associate

Alex A. Fuiks

Associate

Steven J. Grenfell

Senior Vice President and Managing Director, Operations

Mark A. Herndon

Senior Vice President and Chief Financial Officer

Gary J. Kurtzman

Senior Vice President and Managing Director, Healthcare

Mark Mitchell

Vice President and Managing Director

Russell E. Palmer

Former Director

Robert J. Rosenthal

Chairman of the Board

Eric C. Salzman

CEO

Heinz C. Schimmelbusch

Former Director

John E. Shave

Senior Vice President, Investor Relations and Corporate Communications

Brian Sisko

President and Chief Executive Officer

Seth Zuckerman

Senior Associate, Healthcare

Past deals in Pennsylvania

Trice Medical

Series C in 2019
Trice Medical, Inc. specializes in developing advanced orthopedic diagnostic devices that incorporate camera-enabled and needle-based technologies. The company's products facilitate micro-invasive procedures, allowing for effective visualization and treatment in an office setting, which enhances patient comfort and reduces the need for traditional surgical interventions. By providing instant diagnostic results, Trice Medical aims to improve patient care while minimizing costs for physicians and payors. The company was established in 2011 and is headquartered in Malvern, Pennsylvania.

Trice Medical

Series C in 2017
Trice Medical, Inc. specializes in developing advanced orthopedic diagnostic devices that incorporate camera-enabled and needle-based technologies. The company's products facilitate micro-invasive procedures, allowing for effective visualization and treatment in an office setting, which enhances patient comfort and reduces the need for traditional surgical interventions. By providing instant diagnostic results, Trice Medical aims to improve patient care while minimizing costs for physicians and payors. The company was established in 2011 and is headquartered in Malvern, Pennsylvania.

CloudMine

Series A in 2017
Rethink how you develop mobile applications. Significantly reduce your time to deployment, total cost, and overall ease of mind when it comes to developing mobile applications, integrating disparate datasets and maintaining IT infrastructures. CloudMine is a Managed Mobility solution that: 1) Eliminates the need for ongoing maintenance and management of mobile applications. 2) Accelerates app development by 70% through mobile-optimized infrastructure and a suite of prefabricated web services. 3) Standardizes your mobility platform to provide IT-approved common tooling across all business units.

VitalTrax

Seed Round in 2017
VitalTrax connects patients with clinical trials with its cloud-based clinical trial network. VitalTrax offers Wing, a solution that simplifies clinical trials enrollment. Wing is a clinical trial network that provides innovative ways for people to easily seek optional treatments for themselves or people that they love and play an important role in helping develop new ways to fight diseases.
Cognitive Operational Systems, LLC, based in Philadelphia, Pennsylvania, specializes in developing inventory management solutions for the retail sector through the use of robotics, artificial intelligence, and computer vision. Founded in 2012, the company’s technology enables robots to efficiently navigate retail environments, managing inventory, ensuring compliance with planograms and promotions, and providing indoor localization and navigation. Additionally, it offers mapping capabilities that detail store layouts and architecture. By leveraging university research, Cognitive Operational Systems aims to bridge the gap between academic advancements and practical applications in the fields of artificial intelligence and machine perception.

Aktana

Series B in 2016
Aktana helps life science companies get the most out of artificial intelligence for commercializing their products. Its platform harnesses machine learning algorithms to enable marketing and sales teams to optimize their engagement with prescribing physicians. Aktana supports more than 100 brands and more than half the top 20 pharmaceutical companies worldwide to increase revenue, capitalize on data investments, and drive channel productivity and results. The company’s focus on the life sciences market allows Aktana to understand and incorporate unique market dynamics more deeply than the major AI players. Headquartered in San Francisco, Aktana also has offices in New York, Philadelphia, London, Barcelona, Tokyo, Osaka, and Shanghai.

Noble.MD

Seed Round in 2016
Noble.MD is a healthcare technology company based in Bryn Mawr, Pennsylvania, founded in 2012. The company has developed Theo, a digital healthcare advisory platform designed to assist patients in identifying health and behavioral risks. It engages patients in managing these risks through targeted programs and interventions. The platform captures essential patient data at the point of care, facilitating value-based reimbursement and streamlining the alignment of provider and payer interests. By focusing on real-time patient engagement and data collection, Noble.MD aims to enhance risk identification, coding, and management in modern healthcare settings.

Clutch

Series B in 2015
Clutch Holdings, LLC specializes in customer intelligence and engagement software solutions. The company offers a consumer management platform that integrates point-of-sale (POS) data, e-commerce information, and consumer activity across social and mobile channels. Their services encompass customer relationship management (CRM), channel synthesis, segmentation, loyalty programs, gift card solutions, customer scoring, and various marketing strategies, including email and direct mail campaigns. Clutch targets a diverse range of industries, including footwear, telecom, apparel, automotive, banking, healthcare, and hospitality. Founded in 2012 and headquartered in Ambler, Pennsylvania, Clutch aims to empower business-to-consumer brands by providing innovative, data-driven marketing tools to help them effectively connect with and motivate their customers.

CloudMine

Series A in 2015
Rethink how you develop mobile applications. Significantly reduce your time to deployment, total cost, and overall ease of mind when it comes to developing mobile applications, integrating disparate datasets and maintaining IT infrastructures. CloudMine is a Managed Mobility solution that: 1) Eliminates the need for ongoing maintenance and management of mobile applications. 2) Accelerates app development by 70% through mobile-optimized infrastructure and a suite of prefabricated web services. 3) Standardizes your mobility platform to provide IT-approved common tooling across all business units.

Trice Medical

Series B in 2015
Trice Medical, Inc. specializes in developing advanced orthopedic diagnostic devices that incorporate camera-enabled and needle-based technologies. The company's products facilitate micro-invasive procedures, allowing for effective visualization and treatment in an office setting, which enhances patient comfort and reduces the need for traditional surgical interventions. By providing instant diagnostic results, Trice Medical aims to improve patient care while minimizing costs for physicians and payors. The company was established in 2011 and is headquartered in Malvern, Pennsylvania.

WebLinc

Series A in 2014
WebLinc is the parent company for the ecommerce platform Workarea Commerce Cloud and Orderbot order management system.The Workarea Commerce Platform's modern, agile technologies empower companies running global, omnichannel commerce operations, and enable retailers to consistently out-pace the competition. Weblinc's two products, Workarea Commerce Platform and Orderbot OMS support a number of highly successful retail and B2B clients including URBN's BHLDN and Terrain brands, Sanrio, The Reformation, STAPLES Canada, Buzzfeed, Live Nation, Woodcraft Supplies, and The Bouqs.

Trice Medical

Series B in 2014
Trice Medical, Inc. specializes in developing advanced orthopedic diagnostic devices that incorporate camera-enabled and needle-based technologies. The company's products facilitate micro-invasive procedures, allowing for effective visualization and treatment in an office setting, which enhances patient comfort and reduces the need for traditional surgical interventions. By providing instant diagnostic results, Trice Medical aims to improve patient care while minimizing costs for physicians and payors. The company was established in 2011 and is headquartered in Malvern, Pennsylvania.

Clutch

Venture Round in 2013
Clutch Holdings, LLC specializes in customer intelligence and engagement software solutions. The company offers a consumer management platform that integrates point-of-sale (POS) data, e-commerce information, and consumer activity across social and mobile channels. Their services encompass customer relationship management (CRM), channel synthesis, segmentation, loyalty programs, gift card solutions, customer scoring, and various marketing strategies, including email and direct mail campaigns. Clutch targets a diverse range of industries, including footwear, telecom, apparel, automotive, banking, healthcare, and hospitality. Founded in 2012 and headquartered in Ambler, Pennsylvania, Clutch aims to empower business-to-consumer brands by providing innovative, data-driven marketing tools to help them effectively connect with and motivate their customers.

ThingWorx

Series B in 2011
ThingWorx radically transforms application development for the the connected world, allowing companies to achieve a step change in operational innovation and resource efficiency.

Quinnova Pharmaceuticals

Series B in 2009
Quinnova Pharmaceuticals, Inc., a specialty pharmaceutical company, engages in the development and commercial sale of prescription drug products based on dermal drug delivery platforms. It offers HYDRO 40 foam, a dry skin treatment product; tersi foam, a leave-on foam indicated for the treatment of seborrheic dermatitis and tinea versicolor; rinnovi nail system, a prescription nail system that is designed to clean, treat, and protect diseased, damaged, brittle, and ingrown nails; and cleanse and treat, a pad delivery technology system for the treatment of acne. Quinnova Pharmaceuticals, Inc. was founded in 2003 and is based in Newtown, Pennsylvania.

Avid Radiopharmaceuticals

Series D in 2009
Avid develops molecular imaging agents to aid medical management of chronic human diseases. They are located in Philadelphia, PA. Their mission is to develop new molecular imaging agents capable of changing the medical management of significant, chronic human diseases by identifying the first stages of pathological change, potentially assisting in earlier diagnosis, and better management and development of new therapies.

Garnet Biotherapeutics

Series A in 2009
Garnet BioTherapeutics is a clinical stage, venture-backed cell therapy company focused on dermal-based regenerative therapy.

Tengion

Series C in 2008
Tengion is a clinical-stage biotechnology company focused on the development of neo-organs and neo-tissues derived from a patient's own cells. The company has successfully completed two Phase 2 clinical trials in the United States for its Neo-Bladder Augment, which aims to assist children with neurogenic bladder resulting from spina bifida and adults with similar conditions due to spinal cord injuries. An earlier academic study on a urinary Neo-Bladder Augment was published in The Lancet in April 2006, highlighting its potential benefits. Tengion also holds an effective investigational new drug application for its Neo-Urinary Conduit and anticipates initiating a Phase 1 clinical trial for bladder cancer patients requiring bladder removal.

NuPathe

Series B in 2008
NuPathe Inc. is a specialty pharmaceutical company dedicated to developing and commercializing innovative therapies for neurological and psychiatric disorders. The company's flagship product is Zecuity, a transdermal system utilizing sumatriptan for the acute treatment of migraines in adults. In addition to Zecuity, NuPathe is advancing a pipeline of product candidates, including NP201, designed for the continuous treatment of Parkinson's disease, and NP202, aimed at the long-term management of schizophrenia and bipolar disorder. Both candidates leverage the company's proprietary Long-Acting Delivery technology, which facilitates extended medication release through biodegradable implants. Founded in 2005 and based in Malvern, Pennsylvania, NuPathe operates as a subsidiary of Teva Pharmaceutical Industries Limited. The company actively seeks partnerships to enhance the commercial potential of its products in the United States and internationally.

Portico Systems

Venture Round in 2008
Portico's technology enables healthcare organizations to design, build, service and provide value-based reimbursement to their complex provider networks. It also provides the ability to align and automate key network management activities including, provider enrollment, credentialing, contracting and pricing.

Cellumen

Series B in 2007
Cellumen specializes in cellular systems biology solutions that enhance drug discovery and safety assessment processes for biopharmaceutical researchers. By providing advanced tools for early safety evaluation and discovery toxicology, Cellumen helps organizations improve the accuracy of predicting drug efficacy and safety, ultimately reducing failure rates and development costs. The company's innovative approach addresses the complexities of disease and safety, making it a valuable partner for leading institutions such as the Mayo Clinic, Hamamatsu Photonics K.K., the EPA, FDA, NIH, and prominent pharmaceutical companies. Through its commitment to advancing drug development, Cellumen plays a crucial role in the biopharmaceutical industry.

Avid Radiopharmaceuticals

Series C in 2007
Avid develops molecular imaging agents to aid medical management of chronic human diseases. They are located in Philadelphia, PA. Their mission is to develop new molecular imaging agents capable of changing the medical management of significant, chronic human diseases by identifying the first stages of pathological change, potentially assisting in earlier diagnosis, and better management and development of new therapies.

Beyond.com

Series A in 2007
Beyond.com, Inc. operates an online career network to connect job seekers and employers through career channels, and industry and regional communities. Beyond.com, it’s all about focus – and results. You identify the candidates you want to reach, and we’ll help you target them through relevant industry, local and specialty channels. Using our precise targeting abilities, we are able to deliver quality results through recruitment advertising, email marketing, mobile and social channels, and other highly effective tactics. A focused search means more qualified candidates. Get started today, with Beyond.com.

Portico Systems

Series A in 2006
Portico's technology enables healthcare organizations to design, build, service and provide value-based reimbursement to their complex provider networks. It also provides the ability to align and automate key network management activities including, provider enrollment, credentialing, contracting and pricing.

NuPathe

Series A in 2006
NuPathe Inc. is a specialty pharmaceutical company dedicated to developing and commercializing innovative therapies for neurological and psychiatric disorders. The company's flagship product is Zecuity, a transdermal system utilizing sumatriptan for the acute treatment of migraines in adults. In addition to Zecuity, NuPathe is advancing a pipeline of product candidates, including NP201, designed for the continuous treatment of Parkinson's disease, and NP202, aimed at the long-term management of schizophrenia and bipolar disorder. Both candidates leverage the company's proprietary Long-Acting Delivery technology, which facilitates extended medication release through biodegradable implants. Founded in 2005 and based in Malvern, Pennsylvania, NuPathe operates as a subsidiary of Teva Pharmaceutical Industries Limited. The company actively seeks partnerships to enhance the commercial potential of its products in the United States and internationally.

RedSiren

Series B in 2003
RedSiren's integrated security process includes the most critical and often-neglected component of an effective security program: security awareness and training for all employees who have access to information technology resources. End users often are a corporate information security program's weakest link. Through their unique Information Security UniversityTM (InfoSecUTM), RedSiren offers a comprehensive, affordable, Web-based security awareness curriculum to organizations and individuals who want to expand their understanding of information security principles and best practice. The courses are self-paced and highly interactive. InfoSecU provides on-demand training to individual users from a variety of platforms and locations. Evaluation, tracking and reporting tools enable individuals and managers to track progress and assess mastery. Enterprise licensing of the InfoSecU courseware is available to allow you to host the InfoSecU library on internal Learning Management Systems servers. Individual courses and tracks can be licensed to meet your specific needs.

E-Duction

Series B in 2000
E-Duction is at the forefront of the evolving payment industry – paying for goods and services via payroll deduction. The current advent of consumerism is creating demand for more complex payroll deduction products, including variable and dynamic products in which the deduction/payment amount may change each month. E-Duction's transaction processing capabilities make possible a wide range of profitable, consumer-friendly payroll deduction-based services which meet the key demands of today's large and small employers alike.

eonDigital

Venture Round in 2000
eonDigital provides a web-based application which presents an intuitive environment for workgroup collaboration, project control, content management, digital rights protection and customized, on-demand publishing.

Internet Publishing Group

Venture Round in 2000
A provider of specialized market news and analysis for B2B Web sites.

iGrandparents.com

Series A in 2000
IGrandparents is a blog that focuses on enriching the grandparent/grandchild relationship.

Atlas Commerce

Venture Round in 2000
Atlas Commerce delivers Internet business applications for private eHubs. They're enabling global organizations to turn their existing business partnerships into competitive advantage by automating sourcing processes, improving management of supply and demand, and integrating commerce transactions across their entire value chain. They're demonstrating their expertise by supporting strategic sourcing of direct materials; multi-tier, multi-language, multi-currency commerce transactions; collaborative forecasting, planning, and replenishment; and XML integration with legacy applications and trading exchanges. They're proving their value by helping customers achieve increased revenue, lower cost of goods sold, improved margins, and faster customer response times. Atlas Commerce is a Safeguard Scientifics (NYSE:SFE) partner company. Safeguard is a leader in identifying, developing and operating premier technology companies in the Internet infrastructure market with a focus on three sectors: software, communications, and eServices. The Safeguard network consists of 49 direct holdings and an extended network of over 300 Internet-centric companies. Founded in January 1998, Atlas Commerce is headquartered in Malvern, PA, with offices worldwide. For additional information, please contact us at info@atlascommerce.com.

E-Duction

Series A in 2000
E-Duction is at the forefront of the evolving payment industry – paying for goods and services via payroll deduction. The current advent of consumerism is creating demand for more complex payroll deduction products, including variable and dynamic products in which the deduction/payment amount may change each month. E-Duction's transaction processing capabilities make possible a wide range of profitable, consumer-friendly payroll deduction-based services which meet the key demands of today's large and small employers alike.

iMedium

Series B in 2000
IMedium, Inc. develops an Application Service Provider (ASP) that enables the delivery of highly visual, intuitive Web interactions to business customers, future clients and trading partners.

HoopsTV.com

Series B in 1999
HoopsTV.com turns your computer into a 24-hour basketball network, delivering a world of basketball.