The Engine

Vaxess Technologies is a biotechnology company focused on silk biomaterial platforms for vaccine and therapeutic delivery. It develops the MIMIX microneedle patch for transdermal, sustained-release delivery of vaccines and therapies, designed to improve stability and ease of use, including formulations that do not require cold chain storage. The MATRIX formulation and drying platform supports thermostable vaccine, therapeutic, and diagnostic products. The company aims to enable long-term immune responses and easier distribution, including in low-resource settings. Its technology supports oncology and infectious disease applications, including therapies that promote durable anti-tumor immunity and improved treatment outcomes. Founded in 2011 and based in Boston, the company positions its platforms to enable stable, targeted delivery and potentially reduce treatment burden for patients.

Vaxess Technologies is a biotechnology company focused on silk biomaterial platforms for vaccine and therapeutic delivery. It develops the MIMIX microneedle patch for transdermal, sustained-release delivery of vaccines and therapies, designed to improve stability and ease of use, including formulations that do not require cold chain storage. The MATRIX formulation and drying platform supports thermostable vaccine, therapeutic, and diagnostic products. The company aims to enable long-term immune responses and easier distribution, including in low-resource settings. Its technology supports oncology and infectious disease applications, including therapies that promote durable anti-tumor immunity and improved treatment outcomes. Founded in 2011 and based in Boston, the company positions its platforms to enable stable, targeted delivery and potentially reduce treatment burden for patients.

Vaxess Technologies is a biotechnology company focused on silk biomaterial platforms for vaccine and therapeutic delivery. It develops the MIMIX microneedle patch for transdermal, sustained-release delivery of vaccines and therapies, designed to improve stability and ease of use, including formulations that do not require cold chain storage. The MATRIX formulation and drying platform supports thermostable vaccine, therapeutic, and diagnostic products. The company aims to enable long-term immune responses and easier distribution, including in low-resource settings. Its technology supports oncology and infectious disease applications, including therapies that promote durable anti-tumor immunity and improved treatment outcomes. Founded in 2011 and based in Boston, the company positions its platforms to enable stable, targeted delivery and potentially reduce treatment burden for patients.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Sync Computing Corp., established in 2019 and headquartered in Cambridge, Massachusetts, specializes in manufacturing Optimization Processing Units (OPUs). These units are designed to tackle combinatorial optimization problems across various sectors such as telecom, pharma, finance, logistics, and machine learning-dependent industries. Sync Computing's OPU is essentially an algorithm in hardware form, enabling organizations to efficiently solve complex optimization challenges.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Founded in 2018, Quaise is an innovative energy company based in Cambridge, Massachusetts. It specializes in developing and commercializing advanced millimeter-wave drilling systems to access geothermal energy sources worldwide, overcoming geographical limitations.

Founded in 2017, Resonant Link specializes in developing and manufacturing advanced wireless charging solutions. Utilizing coil technology, their products offer highly efficient power transfer for a wide range of applications, from electric vehicles to medical devices.

Sync Computing Corp., established in 2019 and headquartered in Cambridge, Massachusetts, specializes in manufacturing Optimization Processing Units (OPUs). These units are designed to tackle combinatorial optimization problems across various sectors such as telecom, pharma, finance, logistics, and machine learning-dependent industries. Sync Computing's OPU is essentially an algorithm in hardware form, enabling organizations to efficiently solve complex optimization challenges.

Founded in 2017, Commonwealth Fusion is a research company developing fusion energy through an inexhaustible power plant. It combines proven physics with revolutionary superconducting magnet technology to accelerate the path to commercial fusion energy.

Via Separations, Inc. is a company that specializes in developing membrane-based products for the separation of industrial liquids, aimed at enhancing efficiency in challenging industrial environments. Founded in 2016 and based in Somerville, Massachusetts, the company focuses on industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing processes. Via's technology allows facilities to cut energy usage by 90% during chemical separation, replacing traditional heat-based methods with a highly selective and robust membrane filtration system. This advancement not only helps to minimize the environmental impact of industrial processes, but it also creates additional revenue opportunities for customers. Currently, Via is conducting pilot trials at pulp and paper facilities with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. The company has successfully scaled its technology and demonstrated working prototypes at a commercial level, having emerged from MIT's Department of Material Science & Engineering.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Boston Metal is a metallurgy company specializing in reducing the carbon footprint of steel production. It offers industrial-scale solutions using its Molten Oxide Electrolysis (MOE) process, enabling greener and more efficient metal production.

Founded by MIT researchers and industry veterans in 2018, The Routing Company develops a real-time driver and rider application for shared rides. It offers fleet management solutions, including private fleets, demand-responsive transit, analytics dashboards, and transit/paratransit services. Leveraging proprietary AI, the company's platform optimizes vehicle routing from multiple points of demand to one vehicle, enhancing transport equity, accessibility, cost efficiency, and sustainability.

Zapata Computing, Inc. is a quantum software company that specializes in developing innovative computing solutions tailored for industrial and commercial applications. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company emerged from Harvard University and is driven by a team of scientists, including Alán Aspuru-Guzik. Zapata offers Orquestra, a software platform that enables the composition of quantum workflows using a YAML-compatible language, facilitating tasks across both quantum and classical hardware. Its solutions are hardware-agnostic and cater to various sectors, including finance, healthcare, pharmaceuticals, transportation, logistics, energy, and more. Equipped to address complex challenges, Zapata Computing focuses on simulation, optimization, and machine learning, helping enterprise organizations harness the power of quantum technology to enhance their operations.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

WoHo is a company based in Cambridge, Massachusetts, founded in 2020, that focuses on innovative construction systems and technology. It aims to revolutionize the building process by assembling teams, networks, and systems to create both low and high-rise structures with exceptional quality, precision, and efficiency. WoHo's platform integrates architecture, engineering, and construction, providing clients with sustainable and cost-effective solutions for various living and working spaces. By streamlining these processes, WoHo offers competitive alternatives in the construction industry, enhancing the overall efficiency of project delivery.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Founded in 2018, Quaise is an innovative energy company based in Cambridge, Massachusetts. It specializes in developing and commercializing advanced millimeter-wave drilling systems to access geothermal energy sources worldwide, overcoming geographical limitations.

Founded in 2017, Commonwealth Fusion is a research company developing fusion energy through an inexhaustible power plant. It combines proven physics with revolutionary superconducting magnet technology to accelerate the path to commercial fusion energy.

Biobot Analytics, Inc. is a wastewater epidemiology company based in Cambridge, Massachusetts, founded in 2017. It specializes in transforming wastewater infrastructure into public health observatories through innovative technology that analyzes sewage for health-related data. By deploying proprietary sampling devices and spatial analytics, Biobot measures various health threats, including infectious diseases, antibiotic resistance, and drug consumption patterns. The company's Opioid Consumption Monitoring Program specifically estimates opioid use in urban areas by analyzing wastewater. This approach generates anonymized public health data that is independent of traditional hospital reporting systems, allowing for rapid adaptability to emerging public health threats. Biobot Analytics offers its insights as a service, providing government officials with actionable data to prioritize interventions and address public health challenges effectively.

Sync Computing Corp., established in 2019 and headquartered in Cambridge, Massachusetts, specializes in manufacturing Optimization Processing Units (OPUs). These units are designed to tackle combinatorial optimization problems across various sectors such as telecom, pharma, finance, logistics, and machine learning-dependent industries. Sync Computing's OPU is essentially an algorithm in hardware form, enabling organizations to efficiently solve complex optimization challenges.

ISEE develops AI-based solutions for autonomous driving in logistics. Founded in 2016, the company is headquartered in Cambridge, Massachusetts. ISEE's autonomous yard trucks help businesses like Maersk automate their logistics hubs, improving safety, reducing costs, and enhancing driving performance.

E25Bio Inc. is a biotechnology company based in Cambridge, Massachusetts, founded in 2018, that focuses on developing rapid diagnostic tests for epidemic fever viruses. The company designs paper-based diagnostic systems and kits that facilitate the detection of viruses such as dengue, chikungunya, and Zika. E25Bio's innovative platform enables multiplexed testing that quickly identifies viral antigens during infections, allowing for real-time data reporting through a mobile application. This capability supports epidemiologic predictions and disease mapping, empowering governments and health organizations to respond effectively to outbreaks and manage public health crises. Through its commitment to fast, mobile testing solutions, E25Bio aims to prevent severe health outcomes associated with viral epidemics.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Founded in 2017, Commonwealth Fusion is a research company developing fusion energy through an inexhaustible power plant. It combines proven physics with revolutionary superconducting magnet technology to accelerate the path to commercial fusion energy.

Vaxess Technologies is a biotechnology company focused on silk biomaterial platforms for vaccine and therapeutic delivery. It develops the MIMIX microneedle patch for transdermal, sustained-release delivery of vaccines and therapies, designed to improve stability and ease of use, including formulations that do not require cold chain storage. The MATRIX formulation and drying platform supports thermostable vaccine, therapeutic, and diagnostic products. The company aims to enable long-term immune responses and easier distribution, including in low-resource settings. Its technology supports oncology and infectious disease applications, including therapies that promote durable anti-tumor immunity and improved treatment outcomes. Founded in 2011 and based in Boston, the company positions its platforms to enable stable, targeted delivery and potentially reduce treatment burden for patients.

Zapata Computing, Inc. is a quantum software company that specializes in developing innovative computing solutions tailored for industrial and commercial applications. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company emerged from Harvard University and is driven by a team of scientists, including Alán Aspuru-Guzik. Zapata offers Orquestra, a software platform that enables the composition of quantum workflows using a YAML-compatible language, facilitating tasks across both quantum and classical hardware. Its solutions are hardware-agnostic and cater to various sectors, including finance, healthcare, pharmaceuticals, transportation, logistics, energy, and more. Equipped to address complex challenges, Zapata Computing focuses on simulation, optimization, and machine learning, helping enterprise organizations harness the power of quantum technology to enhance their operations.

Via Separations, Inc. is a company that specializes in developing membrane-based products for the separation of industrial liquids, aimed at enhancing efficiency in challenging industrial environments. Founded in 2016 and based in Somerville, Massachusetts, the company focuses on industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing processes. Via's technology allows facilities to cut energy usage by 90% during chemical separation, replacing traditional heat-based methods with a highly selective and robust membrane filtration system. This advancement not only helps to minimize the environmental impact of industrial processes, but it also creates additional revenue opportunities for customers. Currently, Via is conducting pilot trials at pulp and paper facilities with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. The company has successfully scaled its technology and demonstrated working prototypes at a commercial level, having emerged from MIT's Department of Material Science & Engineering.

Boston Metal is a metallurgy company specializing in reducing the carbon footprint of steel production. It offers industrial-scale solutions using its Molten Oxide Electrolysis (MOE) process, enabling greener and more efficient metal production.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Zapata Computing, Inc. is a quantum software company that specializes in developing innovative computing solutions tailored for industrial and commercial applications. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company emerged from Harvard University and is driven by a team of scientists, including Alán Aspuru-Guzik. Zapata offers Orquestra, a software platform that enables the composition of quantum workflows using a YAML-compatible language, facilitating tasks across both quantum and classical hardware. Its solutions are hardware-agnostic and cater to various sectors, including finance, healthcare, pharmaceuticals, transportation, logistics, energy, and more. Equipped to address complex challenges, Zapata Computing focuses on simulation, optimization, and machine learning, helping enterprise organizations harness the power of quantum technology to enhance their operations.

Suono Bio, Inc. is a biotechnology company based in Medford, Massachusetts, that focuses on designing and developing innovative therapeutic products with a unique delivery technology. Established in 2016, the company specializes in enabling ultra-rapid, localized delivery of small molecules, biologics, nucleic acids, and gene therapies directly to the gastrointestinal tract without the need for encapsulation. Suono Bio aims to transform the treatment landscape for difficult-to-treat diseases, particularly those mediated by inflammatory processes, by facilitating effective therapy delivery that enhances patient recovery from gastrointestinal conditions.

Via Separations, Inc. is a company that specializes in developing membrane-based products for the separation of industrial liquids, aimed at enhancing efficiency in challenging industrial environments. Founded in 2016 and based in Somerville, Massachusetts, the company focuses on industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing processes. Via's technology allows facilities to cut energy usage by 90% during chemical separation, replacing traditional heat-based methods with a highly selective and robust membrane filtration system. This advancement not only helps to minimize the environmental impact of industrial processes, but it also creates additional revenue opportunities for customers. Currently, Via is conducting pilot trials at pulp and paper facilities with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. The company has successfully scaled its technology and demonstrated working prototypes at a commercial level, having emerged from MIT's Department of Material Science & Engineering.

C2Sense develops chemiresistive gas sensors for food and agriculture applications, monitoring fruit ripeness and meat/fish/poultry freshness. Its sensors detect ethylene and biogenic amines at low concentrations, helping reduce waste throughout the supply chain.

ISEE develops AI-based solutions for autonomous driving in logistics. Founded in 2016, the company is headquartered in Cambridge, Massachusetts. ISEE's autonomous yard trucks help businesses like Maersk automate their logistics hubs, improving safety, reducing costs, and enhancing driving performance.