GeneChem

Inversago Pharma Inc. is a preclinical-stage biotechnology company based in Montreal, Canada, focused on developing innovative therapies targeting metabolic and fibrotic disorders. The company specializes in peripherally-restricted CB1 receptor inverse agonists, which aim to offer new treatment options for conditions such as Prader-Willi syndrome, diabetes, and related metabolic disorders. Inversago Pharma's research includes addressing complications associated with diabetic kidney disease, non-alcoholic steatohepatitis, and various fibrotic diseases, including interstitial lung disease. Founded in 2015, the company is dedicated to enhancing patient outcomes through its pioneering approach to CB1 blockade.

Triad Life Sciences, established in 2017 and headquartered in Memphis, Tennessee, is a biotechnology company focused on developing bioactive tissue-based materials and therapies. With a collective leadership experience of over 100 years in regenerative medicine, the company specializes in the science of bioactive extracellular matrixes (ECM). Triad's primary business involves creating and distributing innovative, cost-effective wound-healing therapies to treat acute and chronic wounds, soft tissue injuries, and other regenerative applications, with a particular emphasis on incisional wounds, hard-to-heal wounds, and burns.

Giiant Pharma is a preclinical-stage biotechnology company focused on developing innovative therapies for inflammatory bowel diseases (IBD). Utilizing its proprietary Precision Delivery technology platform, Giiant designs gut-restricted, tissue-specific small molecule drug therapeutics that target specific biological pathways in gastroenterology. The company's lead program, GT-2108, is a microbiota-activated PDE4 inhibitor prodrug, which aims to improve drug tolerability while enhancing therapeutic effects. By releasing its active form specifically in the colon, Giiant's approach allows for targeted treatment at the site of inflammation, potentially preventing the worsening of patients' conditions.

Inversago Pharma Inc. is a preclinical-stage biotechnology company based in Montreal, Canada, focused on developing innovative therapies targeting metabolic and fibrotic disorders. The company specializes in peripherally-restricted CB1 receptor inverse agonists, which aim to offer new treatment options for conditions such as Prader-Willi syndrome, diabetes, and related metabolic disorders. Inversago Pharma's research includes addressing complications associated with diabetic kidney disease, non-alcoholic steatohepatitis, and various fibrotic diseases, including interstitial lung disease. Founded in 2015, the company is dedicated to enhancing patient outcomes through its pioneering approach to CB1 blockade.

Liminal BioSciences Inc. is a clinical-stage biopharmaceutical company that specializes in the discovery, development, and commercialization of innovative treatments for patients with unmet medical needs, particularly focusing on rare and orphan diseases. The company operates through two main segments: Small Molecule Therapeutics and Plasma Derived Therapeutics. Its lead product candidate, fezagepras, targets idiopathic pulmonary fibrosis, respiratory diseases, and Alström Syndrome. In the Plasma Derived Therapeutics segment, Liminal BioSciences offers a Plasma Protein Purification System for extracting and purifying therapeutic proteins from human plasma and is developing Ryplazim for congenital plasminogen deficiency. Founded in 1992 and headquartered in Laval, Quebec, the company has a presence in Canada, the United Kingdom, and the United States. It was previously known as Prometic Life Sciences Inc. before rebranding in October 2019.

Inversago Pharma Inc. is a preclinical-stage biotechnology company based in Montreal, Canada, focused on developing innovative therapies targeting metabolic and fibrotic disorders. The company specializes in peripherally-restricted CB1 receptor inverse agonists, which aim to offer new treatment options for conditions such as Prader-Willi syndrome, diabetes, and related metabolic disorders. Inversago Pharma's research includes addressing complications associated with diabetic kidney disease, non-alcoholic steatohepatitis, and various fibrotic diseases, including interstitial lung disease. Founded in 2015, the company is dedicated to enhancing patient outcomes through its pioneering approach to CB1 blockade.

SemaThera Inc. is a biotechnology company based in Montreal, Canada, focused on developing innovative therapies targeting the SEMA 3A protein for the treatment of various ocular diseases, particularly diabetic macular edema and wet age-related macular degeneration. Established in 2016 as a spin-off from the AmorChem Venture Fund 1, SemaThera's technology originates from the research of Dr. Mike Sapieha at Hôpital Maisonneuve-Rosemont. The company's efforts aim to provide effective protein inhibitors that can address not only ocular conditions but also have potential applications in treating cancer and neurodegenerative diseases.

Osprey Pharmaceuticals USA, Inc. is a clinical-stage biotechnology company based in San Francisco, California, that specializes in developing protein therapeutics aimed at treating inflammatory and immune diseases. Founded in 2008, the company focuses on a pipeline of proprietary fusion protein therapeutics known as Leukocyte Population Modulators (LPMs). These therapeutics are designed to selectively target and neutralize chemokine-activated leukocytes, which play a crucial role in various inflammatory conditions. Osprey's lead candidate, CCL2-LPM, specifically targets the CCR2 chemokine receptor found on pathologically activated leukocytes and is currently undergoing a Phase Ib clinical trial for the treatment of IgA nephropathy, an inflammatory kidney disease.

Ambit Biosciences is a privately-held biopharmaceutical company that specializes in the discovery and development of small molecule kinase inhibitors aimed at treating cancer and inflammatory diseases. The company's lead compound, AC220, is a selective and orally bioavailable inhibitor of FMS-like tyrosine kinase-3 (FLT3), currently undergoing clinical trials for patients with relapsed or refractory acute myeloid leukemia (AML). Ambit is collaborating with Astellas Pharma Inc. to jointly develop and commercialize FLT3 kinase inhibitors across various therapeutic areas. In addition to AC220, Ambit's clinical pipeline features AC480, a pan-HER inhibitor, and AC430, an oral inhibitor of JAK2. Furthermore, the company has several preclinical candidates, including CEP-32496, a BRAF inhibitor that is licensed to Cephalon. Through its innovative approach, Ambit aims to enhance treatment outcomes for cancer patients.

Osprey Pharmaceuticals USA, Inc. is a clinical-stage biotechnology company based in San Francisco, California, that specializes in developing protein therapeutics aimed at treating inflammatory and immune diseases. Founded in 2008, the company focuses on a pipeline of proprietary fusion protein therapeutics known as Leukocyte Population Modulators (LPMs). These therapeutics are designed to selectively target and neutralize chemokine-activated leukocytes, which play a crucial role in various inflammatory conditions. Osprey's lead candidate, CCL2-LPM, specifically targets the CCR2 chemokine receptor found on pathologically activated leukocytes and is currently undergoing a Phase Ib clinical trial for the treatment of IgA nephropathy, an inflammatory kidney disease.

Cytochroma is a clinical stage specialty pharmaceutical company that designs, develops and commercializes prescription products to treat and prevent the clinical consequences of vitamin D insufficiency and secondary hyperparathyroidism (SHPT) associated with chronic kidney disease (CKD). The Company has an advanced portfolio of new therapies designed to safely and effectively treat patients with vitamin D insufficiency and SHPT associated with Stage 3, 4 or 5 CKD. In addition, Cytochroma is developing novel therapies to treat elevated blood phosphorus levels (hyperphosphatemia) in order to improve the control of SHPT in CKD patients.

Xanthus Pharmaceuticals Inc. is a biopharmaceutical company dedicated to the discovery, development, acquisition, and commercialization of small-molecule therapeutics targeting cancer and autoimmune disorders. The company specializes in creating innovative treatments that address unmet medical needs in these critical areas. Through its focused approach, Xanthus Pharmaceuticals aims to advance healthcare solutions that improve patient outcomes and enhance the quality of life for those affected by these diseases.

Ambit Biosciences is a privately-held biopharmaceutical company that specializes in the discovery and development of small molecule kinase inhibitors aimed at treating cancer and inflammatory diseases. The company's lead compound, AC220, is a selective and orally bioavailable inhibitor of FMS-like tyrosine kinase-3 (FLT3), currently undergoing clinical trials for patients with relapsed or refractory acute myeloid leukemia (AML). Ambit is collaborating with Astellas Pharma Inc. to jointly develop and commercialize FLT3 kinase inhibitors across various therapeutic areas. In addition to AC220, Ambit's clinical pipeline features AC480, a pan-HER inhibitor, and AC430, an oral inhibitor of JAK2. Furthermore, the company has several preclinical candidates, including CEP-32496, a BRAF inhibitor that is licensed to Cephalon. Through its innovative approach, Ambit aims to enhance treatment outcomes for cancer patients.

NewBiotics is a U.S.-based biotechnology company founded in 1997, specializing in the discovery and development of therapeutic agents that exploit drug resistance mechanisms in cancer and infectious diseases. The company focuses on creating drug molecules that can transform drug resistance into therapeutic advantages, utilizing Enzyme Catalyzed Therapeutic Agents in its research. Notably, NewBiotics has identified the presence of double-minute chromosomes, which are unique to cancer cells, and has developed technology for the purification of double minute DNA from tumor cells. In 2004, NewBiotics was acquired by Celmed Biosciences, further advancing its mission in the field of therapeutics.

Xanthus Pharmaceuticals Inc. is a biopharmaceutical company dedicated to the discovery, development, acquisition, and commercialization of small-molecule therapeutics targeting cancer and autoimmune disorders. The company specializes in creating innovative treatments that address unmet medical needs in these critical areas. Through its focused approach, Xanthus Pharmaceuticals aims to advance healthcare solutions that improve patient outcomes and enhance the quality of life for those affected by these diseases.

LymphoSign is a pharmaceutical company that is focused on the development of drugs for blood cancers. LymphoSign was acquired by Aegera Therapeutics in August 2007. LymphoSign was founded in 2000 and is based in Markham, Canada.

IDUN Pharmaceuticals, Inc., a biopharmaceutical company, engages in the discovery and development of human therapeutics to control apoptosis. Its products under Phase 2 and preclinical trials include drugs for liver disease, CNS diseases, inflammation, and cancer, as well as IDN-6556 for the treatment of liver diseases in patients infected with Hepatitis C virus. The company was founded in 1993 and is based in San Diego, California. As of July 30, 2010, IDUN Pharmaceuticals, Inc. operates as a subsidiary of Conatus Pharmaceuticals Inc.

Copernicus Therapeutics, Inc. is a biotechnology company based in Cleveland, Ohio, focused on developing a non-viral delivery system for nucleic acid drugs. The company's proprietary nanoparticle platform allows for effective gene transfer across various tissues while minimizing immune responses, a common issue with traditional AAV therapies. Copernicus Therapeutics aims to address the root causes of diseases such as cystic fibrosis and is also exploring treatments for a range of serious conditions with limited therapeutic options. These include ocular disorders like macular degeneration and glaucoma, neurological disorders such as Alzheimer’s and Parkinson’s disease, and pulmonary disorders, including chronic obstructive pulmonary disease and asthma. Established in 1995, the company was formerly known as Copernicus Gene Systems, Inc. and rebranded in 1997.

Scion Pharmaceuticals is a biotechnology company that specializes in the research and development of small-molecule drugs aimed at treating central nervous system (CNS) disorders and cardiovascular diseases. The company focuses on identifying and optimizing these therapeutic agents, particularly ion channel modulators, to address unmet medical needs in these critical areas. Through its innovative research services, Scion Pharmaceuticals aims to advance drug discovery and contribute to the development of effective treatments for patients suffering from complex health conditions.

Salmedix is an oncology drug development company with a commercial focus on the treatment of hematologic malignancies, or blood cancers. Its primary product, SDX-105, is marketed by healthcare professionals in Germany for the treatment of several types of blood cancers. Salmedix conducts Phase II clinical trials for SDX-105 in the U.S. and Canada. Its other clinical-stage product candidates, SDX-101 and SDX-102, each with significant prior human clinical experience, are also in Phase II development. Founded in 2000 by David Kabakoff, Salmedix is headquartered in San Diego, California.

Aegera Therapeutics is a clinical stage biotechnology company that specializes in developing targeted therapeutics to meet significant unmet medical needs. The company has multiple clinical programs, focusing primarily on oncology and neuropathic pain. Its oncology initiatives include treatments for various cancers, such as chronic lymphocytic leukemia, acute myeloid leukemia, non-small cell lung cancer, pancreatic cancer, and hepatocellular carcinoma. Additionally, Aegera is exploring therapies for solid tumors and peripheral neuropathy in diabetic patients. The company also works on small molecule inhibitors aimed at treating multiple cancers, as well as inflammatory and autoimmune diseases. Aegera is committed to leveraging its core technologies and expertise to identify and advance novel development candidates from preclinical stages into clinical trials.

PhageTech, LLC, established in 2014 and located in Irvine, California, specializes in the development of innovative bacteriophage-based sensors for the rapid detection of diseases in various bodily fluids, including urine and blood. The company's technology aims to identify early-stage cancers and infectious diseases, allowing for accurate and convenient diagnostics that facilitate timely treatment. This approach addresses critical health issues such as sepsis and MRSA while targeting the global in vitro diagnostics market. By providing low-cost, instant results and the ability to detect multiple disease biomarkers simultaneously, PhageTech's sensors offer a significant advancement over traditional antibody-based methods, which are often expensive and require strict storage conditions. The company's goal is to enhance accessibility to vital health diagnostics, particularly in developing regions, ultimately saving millions of lives worldwide.

Cytochroma is a clinical stage specialty pharmaceutical company that designs, develops and commercializes prescription products to treat and prevent the clinical consequences of vitamin D insufficiency and secondary hyperparathyroidism (SHPT) associated with chronic kidney disease (CKD). The Company has an advanced portfolio of new therapies designed to safely and effectively treat patients with vitamin D insufficiency and SHPT associated with Stage 3, 4 or 5 CKD. In addition, Cytochroma is developing novel therapies to treat elevated blood phosphorus levels (hyperphosphatemia) in order to improve the control of SHPT in CKD patients.

Avalon Pharmaceuticals is a biopharmaceutical company based in Germantown, Maryland, that specializes in the discovery and development of novel cancer therapeutics. The company utilizes its proprietary AvalonRx technology to create innovative treatments for hematologic and solid cancers. Its leading candidate, AVN944, is an inosine monophosphate dehydrogenase (IMPDH) inhibitor currently in Phase IIa clinical development. Avalon has established several collaborative agreements with major pharmaceutical companies, including partnerships for the development of oncology therapeutics and small molecule compounds targeting inflammatory diseases. These collaborations enhance its research capabilities and support the advancement of its drug candidates. Founded in 1999, Avalon Pharmaceuticals continues to focus on delivering effective cancer therapies through its extensive research and development initiatives.

Cytochroma is a clinical stage specialty pharmaceutical company that designs, develops and commercializes prescription products to treat and prevent the clinical consequences of vitamin D insufficiency and secondary hyperparathyroidism (SHPT) associated with chronic kidney disease (CKD). The Company has an advanced portfolio of new therapies designed to safely and effectively treat patients with vitamin D insufficiency and SHPT associated with Stage 3, 4 or 5 CKD. In addition, Cytochroma is developing novel therapies to treat elevated blood phosphorus levels (hyperphosphatemia) in order to improve the control of SHPT in CKD patients.

GeneFormatics is a biotechnology company that focuses on structural proteomics. It develops innovative function prediction methods aimed at the rapid identification of biologically relevant targets from extensive sequence data generated by global genomics projects. By harnessing advanced computational techniques, GeneFormatics contributes to the understanding of protein structures and functions, facilitating breakthroughs in biological research and potential therapeutic applications.

Interomex Biopharmaceuticals Inc. is dedicated to the identification of novel biological targets in key cellular processes with the aim of discovering lead compounds for the treatment of disease. The company’s proprietary Repressed Trans-activator (RTATM) technology can be used to detect protein-protein interactions between a host and an infectious agent, as well as within cells in normal and diseased states. A particular advantage of RTATM is its ability to detect the interactions of transcription transactivator proteins, which are key control points in viral infections and cell activation.

NewBiotics is a U.S.-based biotechnology company founded in 1997, specializing in the discovery and development of therapeutic agents that exploit drug resistance mechanisms in cancer and infectious diseases. The company focuses on creating drug molecules that can transform drug resistance into therapeutic advantages, utilizing Enzyme Catalyzed Therapeutic Agents in its research. Notably, NewBiotics has identified the presence of double-minute chromosomes, which are unique to cancer cells, and has developed technology for the purification of double minute DNA from tumor cells. In 2004, NewBiotics was acquired by Celmed Biosciences, further advancing its mission in the field of therapeutics.

GeneFormatics is a biotechnology company that focuses on structural proteomics. It develops innovative function prediction methods aimed at the rapid identification of biologically relevant targets from extensive sequence data generated by global genomics projects. By harnessing advanced computational techniques, GeneFormatics contributes to the understanding of protein structures and functions, facilitating breakthroughs in biological research and potential therapeutic applications.

Elitra Pharmaceuticals in San Diego, CA is a private company categorized under Pharmaceutical Preparations. It was established in 1997 and incorporated in California.

Novalon Pharmaceutical focuses on the development of innovative drugs to address various medical needs. The company is dedicated to creating novel pharmaceuticals by leveraging its technology access and therapeutic programs. Through these initiatives, Novalon aims to enhance treatment options and improve patient outcomes in diverse therapeutic areas.

Viron Therapeutics is a Biotechnology company

Ceptyr, Inc was founded to focus on developing drugs against protein tyrosine phosphatases (PTPs), a largely unexplored niche in pharmaceutical development.

Cytochroma is a clinical stage specialty pharmaceutical company that designs, develops and commercializes prescription products to treat and prevent the clinical consequences of vitamin D insufficiency and secondary hyperparathyroidism (SHPT) associated with chronic kidney disease (CKD). The Company has an advanced portfolio of new therapies designed to safely and effectively treat patients with vitamin D insufficiency and SHPT associated with Stage 3, 4 or 5 CKD. In addition, Cytochroma is developing novel therapies to treat elevated blood phosphorus levels (hyperphosphatemia) in order to improve the control of SHPT in CKD patients.

BioVex is a biotechnology company dedicated to developing and commercializing biological therapies for cancer treatment and the prevention of infectious diseases. Its primary focus is OncoVEXGM-CSF, an oncolytic vaccine that selectively targets and destroys cancer cells while sparing surrounding healthy tissue. This vaccine operates by replicating within solid tumors, leading to cancer cell death, and also stimulates a robust systemic immune response against tumors. OncoVEXGM-CSF has undergone clinical testing in over 110 patients across various solid tumors, including melanoma, head and neck cancer, breast cancer, and pancreatic cancer. The treatment has demonstrated significant efficacy, routinely eliminating tumors at the injection site and achieving overall disease responses during Phase II trials, with no reported recurrences of resolved tumors. Additionally, BioVex is developing ImmunoVEXHSV2, a vaccine aimed at preventing genital herpes.

Lexicon Pharmaceuticals is a biopharmaceutical company focused on the discovery, development, and commercialization of pharmaceutical products to treat various human diseases. The company's portfolio includes several drug candidates in different stages of clinical trials. LX9211 is an orally-delivered small molecule being tested for neuropathic pain treatment. Sotagliflozin, another orally-delivered small molecule, is under investigation for heart failure and type 1 diabetes. Additionally, the company has developed LX4211 for type 2 diabetes, LX2931 for rheumatoid arthritis and other autoimmune diseases, and LX7101 for glaucoma treatment. Lexicon Pharmaceuticals has established collaborations with several pharmaceutical companies, including Bristol-Myers Squibb, Genentech, Organon, Takeda, Symphony Icon, Taconic Farms, and Nuevolution A/S.

Copernicus Therapeutics, Inc. is a biotechnology company based in Cleveland, Ohio, focused on developing a non-viral delivery system for nucleic acid drugs. The company's proprietary nanoparticle platform allows for effective gene transfer across various tissues while minimizing immune responses, a common issue with traditional AAV therapies. Copernicus Therapeutics aims to address the root causes of diseases such as cystic fibrosis and is also exploring treatments for a range of serious conditions with limited therapeutic options. These include ocular disorders like macular degeneration and glaucoma, neurological disorders such as Alzheimer’s and Parkinson’s disease, and pulmonary disorders, including chronic obstructive pulmonary disease and asthma. Established in 1995, the company was formerly known as Copernicus Gene Systems, Inc. and rebranded in 1997.

The Medicines Company is a pharmaceutical firm dedicated to improving the treatment of critical care patients by offering innovative and cost-effective medicines to hospitals worldwide. The company's primary product, Angiomax, is an anticoagulant used in conjunction with aspirin for patients undergoing coronary angioplasty. Additionally, The Medicines Company markets Cleviprex, an injectable emulsion for managing blood pressure when oral medications are not suitable. In its development pipeline, the company has two late-stage products: cangrelor, an investigational antiplatelet agent, and oritavancin, a semi-synthetic lipoglycopeptide antibiotic. Furthermore, The Medicines Company is exploring a serine protease inhibitor, CU2010, which is currently in early-stage development.

Message Pharmaceuticals is a company that provides Communications systems and more.

MethylGene Inc. (TSX:MYG) is a publicly-traded, clinical stage biopharmaceutical company focused on the development and commercialization of novel therapeutics with a focus on cancer. The Company's product candidates include: MGCD265, an oral, multi-targeted kinase inhibitor targeting the Met, VEGF, Ron and Tie-2 receptor tyrosine kinases that is in multiple clinical trials for cancer; MGCD290, a fungal Hos2 inhibitor for use in combination with fluconazole for serious fungal infections which has completed Phase I clinical studies; and mocetinostat (MGCD0103), an oral, isoform-selective HDAC inhibitor for cancer which has been in multiple Phase II clinical trials and is currently in a Phase II trial in refractory or relapsed follicular lymphoma. Mocetinostat is licensed to Taiho Pharmaceutical Co. Ltd in certain Asian countries. A fourth compound discovered using MethylGene's HDAC platform, EVP-0334 - a potential cognition enhancing agent for neurodegenerative diseases has successfully completed Phase I trials sponsored by EnVivo Pharmaceuticals Inc. MethylGene also has a funded collaboration with Otsuka Pharmaceutical Co. Ltd. for applications in ocular diseases using the Company's proprietary kinase inhibitor chemistry.

Gene Logic is a leading integrated genomics company providing comprehensive Genomic Reference Databases and GLP compliant Microarray Services. Over 2/3rd of the top 25 Pharma companies, leading research institutes and emerging biotech companies worldwide have chosen us as their preferred genomics partner and utilize our expertise for understanding underlying mechanisms of diseases, discovery and prioritization of gene targets & biomarkers.