Innovation Works

Advanced Optronics designs and manufactures implantable sensors for intraoperative monitoring. These sensors provide real-time feedback during surgeries, helping reduce trauma and preserve residual hearing, particularly in cochlear implant procedures.

Parcel Health develops sustainable medication packaging made from paper. Their products are brandable, compostable, and offer improved temperature control during shipping compared to traditional plastic bottles.

Rimsys is a leading provider of Regulatory Information Management (RIM) software specifically designed for medical technology companies. The software is tailored for regulatory affairs professionals, enabling them to digitize and automate compliance processes to meet evolving global regulations. Rimsys offers a comprehensive solution that manages global Unique Device Identification (UDI) requirements and facilitates the navigation of essential regulatory components, including product registration, standards management, and regulatory intelligence. By actively tracking product registrations and monitoring relevant technical files and standards, Rimsys simplifies regulatory management for clients, transforming their operations into a more organized and efficient system for teams and international partners.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company specializes in developing innovative solutions for stroke detection. Its flagship product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. By enabling pre-hospital providers to accurately assess patients, AlphaStroke facilitates timely triage and enhances decision-making in critical care scenarios, ultimately aiming to reduce treatment delays and improve patient outcomes.

Revitalize Energy is a consumer health company specializing in eye drops designed to combat digital eye strain. Their product uses a proprietary blend of stimulants and amino acids to provide immediate relief from eye fatigue caused by prolonged screen use.

Hummingbird Systems provides On demand aerial mapping and data analysis of construction sites and agriculture using drones.

BlastPoint is a developer of a predictive AI-powered platform that offers big data solutions to help companies optimize revenue growth and enhance customer engagement. By providing tools to discover, target, and engage humans within their data, BlastPoint enables businesses across various sectors—such as energy, financial services, automotive, and nonprofit organizations—to generate immediate insights into customer engagement challenges. The platform equips clients to identify trends and unlock critical information relevant to specific territories, ultimately empowering them to find, reach, and satisfy customers throughout their lifetime.

Sitewiz is a technology company that specializes in digital experience optimization. It employs generative AI and data-driven analytics to enhance website conversion rates. The company's platform offers AI-driven insights, prioritizing actionable recommendations to improve customer engagement and boost conversion rates. This enables businesses to efficiently focus on the most impactful actions, thereby improving website performance.

CapSen Robotics develops advanced computer vision systems that enable machines to comprehend and navigate cluttered environments. Their core technology, derived from MIT research on 3D object detection, empowers robots and automation systems in various industries such as manufacturing, logistics, and retail inventory management.

Gridwise develops a mobile application for gig economy drivers, empowering them with real-time insights to maximize earnings. Its platform offers demand alerts, passenger data tracking, mileage logging, tax deduction calculation, and performance reporting.

FoodSocial operates a digital recipe creation and cooking platform focused on healthy and efficient cooking. Its platform enables users to discover, plan meals, and shop for recipes, while allowing creators and brands to share their food-related content with followers.

Peoples Energy Analytics offers a comprehensive, data-driven solution for utility customer management. It identifies at-risk customers and connects them with bill assistance programs before they default on payments, helping utility companies reduce unpaid bills and increase revenue recovery.

iTruckr is a technology company specializing in AI-powered communication and logistics solutions for the trucking industry. It offers a cross-platform solution that automates messaging and real-time tracking, connecting dispatchers, drivers, brokers, and warehouses via SMS, WhatsApp, email, and phone calls. Designed for mid-sized fleets, iTruckr eliminates the need for additional apps or complex onboarding, ensuring seamless communication and reducing operational delays. By automating core processes, it optimizes operations, reduces human errors, and enhances profitability, allowing trucking companies to scale without hiring additional staff. The platform provides 24/7 messaging and automation, leading to faster response times, improved driver satisfaction, and fewer delivery delays.

HeadStrait Labs is a medical equipment manufacturing company focused on developing innovative devices for head and neck immobilization in pre-hospital care. The firm aims to enhance patient outcomes during ambulance transportation by providing healthcare professionals with effective solutions to stabilize patients’ head and neck during critical situations. Through its specialized products, HeadStrait Labs addresses the urgent need for reliable immobilization techniques, thereby contributing to improved safety and care in emergency medical settings.

Journey Robotics specializes in aerospace engineering, providing automated baggage-handling systems for airports. Their robotic arms equipped with vacuum grips and machine vision technology enhance safety, efficiency, and passenger experience while reducing labor strain.

Humotech develops the Caplex system, a modular platform that enables real-time emulation and data capture for prosthetics, orthotics, and exoskeletons. This reduces development cycles and enhances clinical decision-making, allowing researchers and clinicians to optimize assistive device performance with evidence-based insights.

ForSight specializes in health technology, offering a sensory augmentation system designed for individuals with disabilities. Their wearable device system employs sensors and software to safely guide users, enhancing their mobility and participation in daily activities.

Reclamation Factory is an Environmental Services offering firm making automated and transparent plastics recycling equipment.

Ocugenix is a therapeutics company developing cancer immunotherapy solutions for ocular diseases. Its pipeline includes immunotherapy approaches and small-molecule medicines designed to counter drug-resistant bacteria that drive fibrosis and angiogenesis, with the aim of enabling cancer-related eye treatments.

Plexision develops cellular biomarkers and personalized diagnostic tests for immunological disorders and solid organ transplantation. Its Pleximmune blood test predicts transplant rejection by measuring antigen-specific white blood cells, supported by patent-pending technology. The company operates a CLIA-certified central laboratory in Pittsburgh providing testing services for transplant recipients and drug developers. Its platform enables assessment of disease risk, prediction of drug efficacy for individual patients, and guidance on dosing for novel immunological therapies, with capabilities including rapid six-hour panels for conditions such as CMV infection and transplant rejection, and a focus on pediatric liver and intestine transplant patients.

Honeycomb Credit operates an online platform facilitating debt crowdfunding between small business owners and their communities or investors. Incorporated in 2017, the company is headquartered in Pittsburgh, Pennsylvania.

Belong For Me is a SAAS firm offering personalized approach to employee through their product CoExperiences.

SignatureDx is a biotechnology company that develops and operates a bioanalytical platform. This platform is designed to detect and monitor complex human diseases in their early, silent stages. The company focuses on non-invasive diagnostic testing, aiming to predict and treat diseases before they cause significant organ damage. By specializing in novel methods, SignatureDx enables individuals to receive timely and successful treatment, thereby improving health outcomes.

Thiopoly develops digital pharmacy management solutions. Their platform combines IoT sensing, AI, cloud computing, and mobile apps to create scalable grab-and-go systems, enhancing medication management's agility, intuitiveness, equity, and efficiency.

Toyz Electronics specializes in developing educational technology solutions. It offers a gamified learning platform that teaches STEAM subjects, entrepreneurship, and storytelling through a unique superhero rap concept. The platform's culturally relevant curriculum combines hip-hop culture, music, gaming, 3D models, comics, and design to engage students and help them develop technical and soft skills.

Good Company Technologies is currently operating in stealth mode.

Founded in 1994, PittMoss manufactures peat-free potting mixtures using recycled paper fibers. Its primary products are PittMoss and PittMoss Prime, serving commercial greenhouse growers, nurseries, and home gardeners in the United States.

Wack is a software development company that specializes in creating tools to enhance security and improve the developer experience in web development. Their primary product, Agentic, is designed to help teams identify and fix production bugs before they affect end-users, enabling confident and scalable software shipping.

Lead-In Record Co. is a music technology firm that specializes in on-demand record manufacturing services tailored for independent artists. By utilizing advanced technologies such as 3D printing and computer numerical control (CNC), the company streamlines the record production process, allowing artists to produce vinyl records quickly and efficiently. This innovative approach enables musicians to meet their specific needs without the constraints of traditional manufacturing methods, making it easier for them to distribute their music in a physical format.

Sensible Photonics is a company focused on developing innovative fiber optic sensing technologies aimed at enhancing the monitoring of grid equipment and energy storage solutions. The company manufactures noninvasive sensors that monitor transformers, batteries, and other electrical assets, providing real-time temperature readings and predictive analytics. These sensors enable the proactive identification of potential failures, including thermal runaway, allowing for timely maintenance and improved reliability. By offering insights into the health of critical electrical equipment, Sensible Photonics enhances operational efficiency, extends equipment lifespan, and contributes to financial savings and safety for its clients.

Sensi Fit is a manufacturer specializing in athletic equipment, primarily developing fitness testing sensors. These sensors are designed to facilitate athletic testing for high-performance athletes, providing real-time quantitative data, biomechanics feedback, and training guidance. This enables athletes to enhance their performance without the need for wearables.

Workers First is a research and design company founded in 2016 and headquartered in Pittsburgh, Pennsylvania. The company specializes in developing innovative polymer materials that enhance worker protection, particularly in hazardous environments. Its patented polymer technology is designed to neutralize acids on contact, making it suitable for use in personal protective equipment and acid-proof linings. This advancement enables workers to perform their jobs safely and effectively in situations where they are exposed to corrosive substances, thereby improving overall safety and productivity in the workplace.

CleverApply is an educational administration platform founded in 2020 and headquartered in Ohio, United States. The company specializes in matching students with universities and educational agents by utilizing artificial intelligence and blockchain technology. Its platform enables users to identify suitable universities based on their desired programs and individual needs. Additionally, CleverApply facilitates connections between students and schools, assists in document review, and provides interview preparation resources, streamlining the application process for prospective students.

PredxBio is a computational pathology company that specializes in the development of artificial intelligence tools for analyzing whole slide image pathology samples through spatial analytics. The company focuses on enhancing the capabilities of clinicians and researchers by providing tools that accelerate drug discovery, optimize clinical trials, and improve companion diagnostics. PredxBio's platform employs AI and machine learning to automatically recognize and classify regions of interest in H&E-stained and immunohistochemistry slides. This technology aids pathologists and biopharma companies in making informed clinical decisions and developing personalized therapeutic strategies. By leveraging personalized spatial intelligence, PredxBio aims to streamline clinical workflows and advance the overall efficiency of the drug development process.

Subtl Beauty, Inc. is a cosmetics brand founded in 2018 and based in Pittsburgh, Pennsylvania. The company specializes in the production of stackable makeup products designed for contemporary women seeking convenience and flexibility in their beauty routines. Its unique packaging allows for modular, customizable stacks that can easily fit in a gym bag, purse, or back pocket, making them ideal for on-the-go lifestyles. Subtl Beauty's product offerings are crafted for efficiency, easy application, and long-lasting wear, aligning with the values of conscious consumers by being clean, vegan, cruelty-free, paraben-free, and fragrance-free. The company's online sales platform further enhances accessibility for customers seeking innovative, travel-friendly makeup solutions.

ExchangeLodge LLC is a financial technology company that specializes in business process automation and data integration for private capital firms. Founded in 2015 and based in Pittsburgh, Pennsylvania, the company offers a platform designed to streamline data management and enhance operational efficiency. This platform provides users with a comprehensive playbook of essential workflows, enterprise data connectors, and high-quality reports suitable for boardroom presentations. By automating manual data processes and integrating existing systems, ExchangeLodge mitigates risks associated with data inaccuracies and key personnel dependencies. The platform enables teams to design and manage reporting, track tasks and their progress, and generate actionable insights for decision-making, ultimately improving data quality and supporting compliance with investor and regulatory requirements.

BioHybrid Solutions is a biotechnology company that specializes in developing advanced nanoarmored protein-polymer conjugates. The company focuses on tailoring the activity and stability of proteins and enzymes for various applications. Utilizing atom transfer radical polymerization chemistry, BioHybrid Solutions precisely grows polymers from the surface of proteins, enhancing their functionality. Through its research and development efforts, the company aims to provide innovative alternatives for therapeutics and protein engineering, ultimately contributing to advancements in medical treatments.

Ecotone Renewables develops sustainable solutions for food waste management. Their flagship product, 'Seahorse', converts organic waste into renewable energy and nutrient-rich fertilizer through anaerobic digestion, aiming to close the food loop.

Founded in 2020, Phlux Technologies specializes in developing innovative 3D sensor technology for robotics and automation. Its products enhance safety and efficiency by enabling robots to navigate effectively, protecting workers from hazards, and detecting obstacles.

Ilant Health specializes in managing obesity and cardiometabolic health. Its platform employs machine learning analytics to drive insights for improved patient outcomes and reduced healthcare costs.

Testa-Seat is a company that specializes in developing affordable, adaptable seating solutions for children with special needs. The firm offers creatively designed, 3D-printed seating devices that enhance mobility and independence for individuals with disabilities. By providing body-contouring therapeutic positioning equipment, Testa-Seat ensures optimal support for users with mild to moderate body control. Their products are aimed at reducing the risks associated with improper seating during critical developmental stages, thereby improving comfort and wellness. Testa-Seat supplies its innovative solutions to rehabilitation centers, hospitals, and private customers, ultimately promoting better mobility and overall well-being for disabled children and adults, along with their families.

MetasTx is a healthcare firm established in 2021, focused on developing innovative therapies aimed at preventing and treating prostate cancer metastasis. The company specializes in creating treatments that specifically target cancer metastasis without adversely affecting the androgen system, which is commonly impacted by traditional therapies. By concentrating on a well-known enzyme that plays a crucial role in cancer initiation and metastasis, MetasTx aims to provide effective solutions for patients suffering from prostate, breast, and skin cancers.

Resilient Lifescience specializes in developing wearable medical devices designed to prevent opioid overdose deaths. Their innovative device detects and automatically administers naloxone, enabling timely intervention even when no one else is present.

Magnify Biosciences specializes in advanced microscopy solutions, offering a high-resolution imaging platform and associated services. Their technology physically expands biological samples, enabling researchers to study complex structures and molecular interactions at the nanoscale, beyond the typical limits of light microscopy. This empowers researchers, entrepreneurs, and diagnostic labs to gain unique insights into cellular architecture, facilitating advancements in life sciences and diagnostics.

D.Sole is a healthcare technology company focused on advancing remote patient monitoring in podiatry through innovative multimodal foot insoles. These insoles are designed for the early detection and monitoring of diabetic foot complications, including ulcers and deformities. By integrating advanced machine learning algorithms, D.Sole provides clinicians with comprehensive foot physiological data, enabling evidence-based insights for targeted treatments. The company's insoles are significantly more affordable than current market options, capable of detecting 15 types of foot complications, in contrast to competitors that only identify one. D.Sole aims to reduce healthcare costs substantially, potentially saving wound clinics over $100 million annually by lowering readmission rates for foot complications. Additionally, private insurers could save over $1 billion by reducing expenses related to amputations and wound care.

Finish Robotics is a company that develops mobile robotics technology aimed at addressing the labor shortage in the construction industry. It specializes in creating semi-autonomous, collaborative robots constructed from standard industrial components. These robots are designed to assist contractors in overcoming challenges related to labor availability, thereby enhancing productivity on construction sites. By leveraging innovative robotics solutions, Finish Robotics seeks to provide effective tools that improve the efficiency and effectiveness of construction operations.

Foundera Beauty is the beauty brand to shop and search for foundation and concealer online by the use of artificial intelligence.

FoodSocial operates a digital recipe creation and cooking platform focused on healthy and efficient cooking. Its platform enables users to discover, plan meals, and shop for recipes, while allowing creators and brands to share their food-related content with followers.

AdSkate employs machine learning and AI technology to enhance digital advertising. Its platform offers insights for campaign planning, direct buy analysis, programmatic integration, content discovery, and content analysis, empowering brands to advertise effectively and make informed decisions.

UpContent develops a SaaS platform that discovers brand mentions and curates digital content from various sources like news articles, blogs, and social media. Its tool automates the content discovery process, allowing users to engage audiences effectively. Founded in 2015, UpContent is headquartered in Pittsburgh, Pennsylvania.

Shelfmark develops a remote inventory management platform that provides real-time product data and optimizes inventory processes. It caters to suppliers, retailers, and e-commerce partners, supporting their inventory needs from forecasting to replenishment.

EKTO VR is a Pittsburgh-based developer of wearable locomotion technology for virtual reality, including a motorized device called Traverse and wearable robotic boots. The devices use rotating plates and wheels to simulate walking in VR, enabling users to move in a defined space while remaining in place, which helps reduce motion sickness. The technology aims to enhance the realism of training simulations and immersive VR experiences for users around the world.

Circadiance LLC is a medical device manufacturing company based in Turtle Creek, Pennsylvania, specializing in respiratory products for individuals with sleep-disordered breathing and those requiring non-invasive ventilation. Founded in 2006, the company develops and markets a range of innovative solutions, including the SleepWeaver all-cloth positive airway pressure masks that enhance comfort during sleep, and the SmartMonitor 2, a portable apnea monitor designed for infants that tracks heart and respiration activity. Additionally, Circadiance offers the SmartMonitor 2 Professional Series for healthcare providers, providing detailed monitoring data, as well as neonatal/pediatric electrodes and the Synergy-E Event Software for analyzing infant apnea data. The NeoPAP system is also part of their product line, designed to treat newborns experiencing respiratory distress syndrome. Circadiance products are distributed through durable medical equipment providers, online retailers, and directly to healthcare professionals, both domestically and internationally.

TalkMeUp is an innovative company focused on enhancing communication skills within organizations, addressing the substantial corporate training market. It offers an AI-driven platform that provides on-demand, personalized coaching tailored to the specific needs of employees. Users can access the platform via their smartphones or computers, receiving instant, objective feedback on their communication performance, which includes aspects such as delivery style and content. TalkMeUp's services are designed to empower employees across various sectors, including retail, education, and hospitality, making it suitable for a wide range of roles, from sales to customer service. By leveraging advanced technology, TalkMeUp aims to improve overall employee competency in diverse professional scenarios.

Agot is an all-in-one computer vision platform for quick-service and other food service brands. It digitizes restaurant activities and translates observations into real-time team interactions and actionable analytics, helping to reduce online order errors, increase order volume and ratings, and improve pickup time estimates while providing operations insights across locations.

DisSolves Inc. is a Pittsburgh-based company specializing in the development and manufacture of dissolvable packaging materials for the food industry. Founded in 2016, DisSolves creates innovative, edible packaging made from natural and plant-based ingredients, specifically designed for single servings of drink mixes such as protein powder and flavor enhancers. Their flagship product, a pod, replaces traditional non-recyclable packaging with a more convenient, environmentally friendly option. DisSolves is committed to sustainability, utilizing renewable and vegan materials such as seaweed and polysaccharides to ensure their packaging is both degradable and safe for consumption. The company aims to enhance consumer convenience while promoting health and environmental responsibility, addressing the growing demand for efficient and eco-friendly food packaging solutions.

Leaficient is a technology company that specializes in energy-saving solutions for Controlled Environment Agriculture (CEA). It develops and deploys low-cost cameras and sensors that monitor plant biometrics and growth, enabling clients to optimize energy usage and enhance crop yield and quality predictably.

Adrich is a Pittsburgh-based company that develops a consumer insights platform consisting of smart packaging hardware and customized software. The platform autonomously collects and transmits product usage data via product labels, capturing day and time, geolocation, and volumetric usage in real time. This data helps brands and retailers understand trends, behaviors, and usage patterns, supporting post-purchase engagement, retention, and targeted service.

Grasp Robotics is evolving into a robotics firm with a wide range of robotic solutions targeted to certain sectors and applications where robots are unable to perform critical jobs.

Realyze Intelligence develops AI-powered software for clinical data analysis. It employs natural language processing to extract insights from unstructured patient notes in electronic medical records, creating comprehensive case studies. This enables healthcare providers to identify specific patient populations with chronic diseases and cancer, facilitating timely access to beneficial treatments.

InceptEV is a technology company specializing in electric vehicle (EV) data solutions for fleet operations. It leverages proprietary data and patented technology to simulate and optimize fleet performance, enabling businesses to make informed decisions about EV adoption and plan for their operational needs.

Aquatonomy provides underwater robot autonomy software that includes localization, mapping, and planning.

Voaige develops robotics solutions for industrial automation, offering safe, affordable, and versatile robotic arms designed to address labor shortages. The company also provides an automation platform that integrates vision, artificial intelligence, and robotics to solve complex industrial use cases. The platform features a modular architecture, continuous learning capabilities, and real-time perception tools, enabling reliable automation, operational consistency, and opportunities for process optimization. The team comprises AI PhDs and robotics engineers from Carnegie Mellon University, reflecting a focus on applying cutting-edge AI to real-world manufacturing challenges.

Velo.AI develops Copilot, an AI-powered bike light that enhances cyclist safety. It offers video recording, audible warnings for approaching vehicles, visual alerts for drivers, and predictive risk estimation to prevent crashes.

Peoples Energy Analytics offers a comprehensive, data-driven solution for utility customer management. It identifies at-risk customers and connects them with bill assistance programs before they default on payments, helping utility companies reduce unpaid bills and increase revenue recovery.

Push2Spin Technologies is dedicated to the development and commercialization of innovative solutions in the fields of plastic and podiatric surgeries. The company aims to transform the global soft tissue grafting market through its unique technology designed for small-volume fat tissue harvesting, processing, and transfer. This novel approach enhances the efficiency of clinical procedures, streamlining the process while reducing time and costs for practitioners. By focusing on disruptive technologies, Push2Spin strives to improve outcomes in soft tissue grafting, ultimately benefiting both clinicians and patients.

Aquatonomy provides underwater robot autonomy software that includes localization, mapping, and planning.

Parcel Health develops sustainable medication packaging made from paper. Their products are brandable, compostable, and offer improved temperature control during shipping compared to traditional plastic bottles.

Mamalux specializes in designing and selling high-quality, leakproof apparel tailored for maternity and breastfeeding. Their online platform offers a range of personal luxury items, including sleepwear designed for comfort during the postpartum period.

Leaficient is a technology company that specializes in energy-saving solutions for Controlled Environment Agriculture (CEA). It develops and deploys low-cost cameras and sensors that monitor plant biometrics and growth, enabling clients to optimize energy usage and enhance crop yield and quality predictably.

Velo.AI develops Copilot, an AI-powered bike light that enhances cyclist safety. It offers video recording, audible warnings for approaching vehicles, visual alerts for drivers, and predictive risk estimation to prevent crashes.

Ariel Precision Medicine, Inc. is an integrated genomics and digital health company focused on providing precision medicine solutions for the diagnosis, monitoring, and treatment of complex chronic diseases and disorders. Founded in 2015 and headquartered in Pittsburgh, Pennsylvania, the company develops innovative clinical decision support tools aimed at simplifying personalized treatment in both emergency departments and clinical settings. One of its key offerings is ArielDx, a cloud-based tool designed to enhance the diagnosis and treatment of pancreatic disease, thereby improving patient outcomes through tailored healthcare solutions.

Module is a company focused on developing modular residential housing projects that emphasize intelligent architectural design. By employing a modular approach, the company aims to make homeownership more accessible and flexible for a broader audience. Its offerings enable buyers to secure the right amount of living space tailored to their needs, while also providing customized housing services. This innovative model positions Module as a provider of affordable housing solutions suitable for the urban environment, catering to the demands of contemporary living.

Apollo Neuroscience, Inc. is a Pittsburgh-based company that manufactures a clinically validated wearable wellness device designed to assist the body in recovering from chronic stress through gentle vibrations. Established in 2016, the company also offers an application that integrates neuroscience and machine learning to enhance heart rate variability, promoting improved routines for waking, focusing, unwinding, and engaging the parasympathetic nervous system. The product is marketed directly to consumers through online sales and is positioned as a wellness solution rather than a treatment for psychiatric disorders.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company specializes in developing innovative solutions for stroke detection. Its flagship product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. By enabling pre-hospital providers to accurately assess patients, AlphaStroke facilitates timely triage and enhances decision-making in critical care scenarios, ultimately aiming to reduce treatment delays and improve patient outcomes.

Make It Home Safe is a mobile application founded in 2017 and headquartered in Pittsburgh, Pennsylvania, that focuses on enhancing safety and security during traffic stops. The app serves as a tool for both motorists and law enforcement, providing real-time identity verification to facilitate smoother interactions. By aiming to reduce tensions between police and the public, Make It Home Safe seeks to create a safer environment on the road, helping to assure users that their safety is prioritized during potentially stressful encounters.

Optimus Technologies is a clean energy technology company headquartered in Pittsburgh, Pennsylvania. It specializes in developing advanced fuel management systems that enable medium and heavy-duty truck fleets to operate on 100% biodiesel. The company's flagship product, the Vector System, integrates seamlessly into existing diesel engines without the need for extensive modifications or replacements. This technology allows fleet operators to achieve significant reductions in fuel costs and emissions while effectively meeting renewable fuel targets. By providing a practical solution for transitioning to low-carbon fuels, Optimus Technologies addresses the challenges of emissions reductions in heavy-duty applications.

SpIntellx, Inc. is a computational and systems pathology company based in Pittsburgh, Pennsylvania, that specializes in spatial intelligence software products designed for analyzing pathology tissue sections in cancer diagnosis. Founded in 2017, the company offers innovative solutions such as SpIntellx, which processes image data sets from various imaging platforms and reagents, and HistoMapr, a computational guide for pathologists. Additionally, TumorMapr is utilized to analyze the spatial interactions of biomarkers within whole slide images using multiplexed fluorescence. With a focus on Precision Pathology and Spatially Intelligent Biology, SpIntellx leverages unbiased spatial analytics powered by explainable AI to enhance understanding of complex cancer biology, thereby facilitating advancements in drug development, diagnostics, and treatment strategies.

Kloopify provides a sustainable procurement platform that helps organizations track, reduce, and report the carbon footprint of their purchased goods and services. The platform delivers analytical visibility across the enterprise, from high-level summaries to detailed category-level insights, and supports procurement measures and reporting to meet sustainability goals and reduce supply chain risk.

Duo Oncology specializes in developing nanoparticle technology designed to penetrate established tumors efficiently. Collaborating with renowned university scientists and medical oncologists, the company aims to accelerate product development through strategic partnerships with established research organizations.

Webvizio is a visual feedback collaboration and productivity platform designed to enhance communication among digital teams and clients during web development projects. The platform facilitates real-time collaboration on live web pages and applications, allowing users to provide visual feedback directly on web elements. It helps streamline the development process by minimizing the need for back-and-forth communication through various channels, such as email and video calls. Users can manage multiple projects simultaneously, assign tasks, set deadlines, and track progress in real time. Webvizio also offers screen recording capabilities and integrates with other productivity software, enabling web builders and team managers to improve overall productivity and efficiency in their workflows.

Toyz Electronics specializes in developing educational technology solutions. It offers a gamified learning platform that teaches STEAM subjects, entrepreneurship, and storytelling through a unique superhero rap concept. The platform's culturally relevant curriculum combines hip-hop culture, music, gaming, 3D models, comics, and design to engage students and help them develop technical and soft skills.

Honeycomb Credit operates an online platform facilitating debt crowdfunding between small business owners and their communities or investors. Incorporated in 2017, the company is headquartered in Pittsburgh, Pennsylvania.

Revitalize Energy is a consumer health company specializing in eye drops designed to combat digital eye strain. Their product uses a proprietary blend of stimulants and amino acids to provide immediate relief from eye fatigue caused by prolonged screen use.

Founded in 2009, Setex Technologies is a Pittsburgh-based manufacturer specializing in dry adhesive technology inspired by gecko feet. They offer micro-fibrillar polymer gripping surfaces for various products, serving both consumers and manufacturers.

LeanFM Technologies provides a cloud-based information and facility operations platform that helps facility managers access actionable information and make data-driven decisions. The platform integrates static design information, dynamic measurements, and controls using standard protocols to automatically map data points from building automation systems to equipment and spaces in design drawings, enabling accurate and productive decision-making. It supports hospitals and universities by offering context on maintenance history and backlog and by delivering AI-enriched insights from maintenance and building information. The goal is to minimize waste and maximize value for owners and occupants by improving maintenance planning, operational transparency, and efficiency.

Handl Health operates a SaaS-based healthcare price transparency platform that aggregates and contextualizes price transparency, insurance, and demographic data. The solution helps health plans comply with CMS price transparency regulations while digitizing how patients shop, book, and pay for healthcare, enabling users to compare costs and make informed purchasing decisions.

InnSight Technology is a biotechnology company focused on advancing the diagnostics and evaluation of eye diseases. The company specializes in developing innovative ophthalmic devices, including a novel, hand-held biosensor designed for the detection of anterior ophthalmic injuries. Additionally, InnSight Technology works on the development of nanotechnology-based medical devices aimed at addressing various clinical needs in ophthalmology. By providing these advanced tools, the company enables clinicians to enhance ocular care and improve patient outcomes in eye health.

NOCTEM Health is a clinical decision support tool focused on addressing insomnia and other sleep disturbances through innovative telehealth solutions. The company provides a platform that enhances patient workflows and delivers effective behavioral sleep treatments by integrating interactive and adaptive tools. This approach combines high-quality sleep care with the cost-efficiency of digital technologies, allowing patients to connect with therapists for real-time assessment, monitoring, and treatment. By empowering clinicians, NOCTEM Health aims to improve the overall delivery of sleep care and meet the unmet healthcare needs in the field of sleep medicine.

Gus Gear is a manufacturer of wearable securement clothing designed to protect implanted medical devices and enhance patient outcomes. The company's flagship product, the Central Line Vest, safeguards central catheters from damage, breakage, and accidental removal, allowing patients to maintain their quality of life while undergoing treatment. In addition to the Central Line Vest, Gus Gear's platform offers securement solutions for various medical devices, including ostomy pouches and feeding tubes. By using innovative securement systems, Gus Gear enables patients to manage their medical challenges effectively, promoting independence and wellbeing.

Respair is a medical device company specializing in innovative airway products designed to assist clinicians and patients in critical care settings. Its proprietary technology replaces traditional inflatable cuffs with soft baffles, creating a secure seal without added pressure, thereby reducing secondary complications.

Buoy is a wellness company focused on supporting hydration through its unflavored electrolyte drops. These drops can be added to any drink, allowing individuals to efficiently maintain their hydration levels without compromising taste.

Voaige develops robotics solutions for industrial automation, offering safe, affordable, and versatile robotic arms designed to address labor shortages. The company also provides an automation platform that integrates vision, artificial intelligence, and robotics to solve complex industrial use cases. The platform features a modular architecture, continuous learning capabilities, and real-time perception tools, enabling reliable automation, operational consistency, and opportunities for process optimization. The team comprises AI PhDs and robotics engineers from Carnegie Mellon University, reflecting a focus on applying cutting-edge AI to real-world manufacturing challenges.

PECA Labs is a Pittsburgh-based medical device company spun out of Carnegie Mellon University and UPMC that develops polymeric heart valves and vascular grafts for pediatric congenital heart disease. Its lead product, the MASA Valve, is a synthetic valved conduit intended for pediatric right ventricular outflow tract reconstruction, leveraging ePTFE material properties and radiopaque markings to improve durability and intraoperative configurability. The company also offers exGraft, an ePTFE vascular graft with radiopaque markers. PECA Labs focuses on orphan patient populations and aims to reduce the need for multiple surgeries in children, with the MASA Valve designed to address limitations of existing conduits. The MASA Valve has received FDA Humanitarian Use Device designation, and early intraoperative implants have demonstrated reduced re-operation rates compared with alternatives. Headquartered in Pittsburgh since its founding around 2011-2012, PECA Labs pursues pediatric cardiovascular solutions with an emphasis on improving long-term outcomes for congenital heart disease patients.

Inspired Cognition is a Pennsylvania-based company that specializes in developing artificial intelligence software tailored for the research and development lifecycle. The company focuses on creating digital tools and online systems that assist businesses in integrating AI solutions effectively. Its products provide evaluation as a service, enabling organizations to monitor, analyze, and improve their operational plans. Additionally, Inspired Cognition’s offerings include data modeling capabilities that help business professionals identify system pain points and propose actionable solutions. Through its innovations, Inspired Cognition aims to support businesses in leveraging AI to enhance their operations and decision-making processes.

Advanced Optronics designs and manufactures implantable sensors for intraoperative monitoring. These sensors provide real-time feedback during surgeries, helping reduce trauma and preserve residual hearing, particularly in cochlear implant procedures.

UpContent develops a SaaS platform that discovers brand mentions and curates digital content from various sources like news articles, blogs, and social media. Its tool automates the content discovery process, allowing users to engage audiences effectively. Founded in 2015, UpContent is headquartered in Pittsburgh, Pennsylvania.

BioHybrid Solutions is a biotechnology company that specializes in developing advanced nanoarmored protein-polymer conjugates. The company focuses on tailoring the activity and stability of proteins and enzymes for various applications. Utilizing atom transfer radical polymerization chemistry, BioHybrid Solutions precisely grows polymers from the surface of proteins, enhancing their functionality. Through its research and development efforts, the company aims to provide innovative alternatives for therapeutics and protein engineering, ultimately contributing to advancements in medical treatments.