Life Sciences Greenhouse of Pennsylvania

Avisi Technologies Inc. is a Philadelphia-based company founded in 2017 that specializes in developing innovative solutions for glaucoma treatment. Its primary product, VisiPlate, is a next-generation, nanotechnology-enabled aqueous shunt designed to prevent blindness caused by glaucoma. Through its advanced technology, Avisi Technologies aims to enhance the effectiveness of glaucoma management and improve patient outcomes.

Micro Interventional Devices, Inc., founded in 2010 and based in Newtown, Pennsylvania, is a medical device company specializing in disruptive technologies for percutaneous and minimally invasive structural heart repair procedures. The company designs and manufactures devices such as Permaseal, which facilitates transapical access and closure for catheter-based procedures, and Minimally Invasive Annuloplasty technology for tricuspid and mitral repair. Additionally, they offer Endovalve, a percutaneous mitral valve replacement system, and Permavalve, a percutaneous mitral valve with active fixation. Their proprietary technology focuses on soft-tissue anchoring and delivery devices, enabling off-pump procedures and transforming open surgical techniques into transcatheter procedures.

MacuLogix, Inc. is a company specializing in the diagnosis, monitoring, and treatment of age-related macular degeneration (AMD), a leading cause of blindness. The company develops innovative tools, including the AdaptDx, a fully automated dark adaptometer that allows eye care professionals to assess the dark adaptation process in patients. This technology enables early detection and tracking of AMD, allowing for intervention up to three years before the disease manifests visually. MacuLogix aims to reduce preventable blindness through its screening tools, which are distributed across the United States and internationally, as well as sold online. Founded in 2008 and based in Harrisburg, Pennsylvania, MacuLogix continues to advance its mission to combat vision loss associated with AMD.

MacuLogix, Inc. is a company specializing in the diagnosis, monitoring, and treatment of age-related macular degeneration (AMD), a leading cause of blindness. The company develops innovative tools, including the AdaptDx, a fully automated dark adaptometer that allows eye care professionals to assess the dark adaptation process in patients. This technology enables early detection and tracking of AMD, allowing for intervention up to three years before the disease manifests visually. MacuLogix aims to reduce preventable blindness through its screening tools, which are distributed across the United States and internationally, as well as sold online. Founded in 2008 and based in Harrisburg, Pennsylvania, MacuLogix continues to advance its mission to combat vision loss associated with AMD.

Indigo Biosciences, Inc. is a biosciences company based in State College, Pennsylvania, founded in 2004. The company specializes in developing products and services centered around nuclear receptors, which are key therapeutic drug targets. Its offerings include various assay kits, in vitro toxicology solutions, and custom assay development, with a focus on enhancing readability, reproducibility, and turnaround times in research. Notably, Indigo provides long-term cryopreservation of cells, facilitating convenient access to robust cell-based reporter assays. The company serves a diverse clientele, including pharmaceutical and biotechnology firms, as well as government research agencies and academic institutions, aiming to streamline the drug discovery process by reducing time, cost, and risk associated with screening small molecule compounds against functional human and non-human nuclear receptors.

MacuLogix, Inc. is a company specializing in the diagnosis, monitoring, and treatment of age-related macular degeneration (AMD), a leading cause of blindness. The company develops innovative tools, including the AdaptDx, a fully automated dark adaptometer that allows eye care professionals to assess the dark adaptation process in patients. This technology enables early detection and tracking of AMD, allowing for intervention up to three years before the disease manifests visually. MacuLogix aims to reduce preventable blindness through its screening tools, which are distributed across the United States and internationally, as well as sold online. Founded in 2008 and based in Harrisburg, Pennsylvania, MacuLogix continues to advance its mission to combat vision loss associated with AMD.

MacuLogix, Inc. is a company specializing in the diagnosis, monitoring, and treatment of age-related macular degeneration (AMD), a leading cause of blindness. The company develops innovative tools, including the AdaptDx, a fully automated dark adaptometer that allows eye care professionals to assess the dark adaptation process in patients. This technology enables early detection and tracking of AMD, allowing for intervention up to three years before the disease manifests visually. MacuLogix aims to reduce preventable blindness through its screening tools, which are distributed across the United States and internationally, as well as sold online. Founded in 2008 and based in Harrisburg, Pennsylvania, MacuLogix continues to advance its mission to combat vision loss associated with AMD.

Micro Interventional Devices, Inc., founded in 2010 and based in Newtown, Pennsylvania, is a medical device company specializing in disruptive technologies for percutaneous and minimally invasive structural heart repair procedures. The company designs and manufactures devices such as Permaseal, which facilitates transapical access and closure for catheter-based procedures, and Minimally Invasive Annuloplasty technology for tricuspid and mitral repair. Additionally, they offer Endovalve, a percutaneous mitral valve replacement system, and Permavalve, a percutaneous mitral valve with active fixation. Their proprietary technology focuses on soft-tissue anchoring and delivery devices, enabling off-pump procedures and transforming open surgical techniques into transcatheter procedures.

Immunomic Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing innovative immunotherapies for cancer, allergies, and animal health. Founded in 2005 and headquartered in Rockville, Maryland, with an additional office in South Korea, the company utilizes its proprietary platforms, including the UNiversal Intracellular Targeted Expression (UNITE) platform and the LAMP-Vax platform. The UNITE platform targets cancer immunotherapy, while LAMP-Vax is designed for DNA vaccines that enhance immune responses by improving antigen presentation. By leveraging lysosomal-associated membrane proteins, Immunomic Therapeutics aims to harness the body’s natural biochemistry to generate robust immune responses, making significant strides in the rapidly evolving fields of allergy and cancer treatment.

Indigo Biosciences, Inc. is a biosciences company based in State College, Pennsylvania, founded in 2004. The company specializes in developing products and services centered around nuclear receptors, which are key therapeutic drug targets. Its offerings include various assay kits, in vitro toxicology solutions, and custom assay development, with a focus on enhancing readability, reproducibility, and turnaround times in research. Notably, Indigo provides long-term cryopreservation of cells, facilitating convenient access to robust cell-based reporter assays. The company serves a diverse clientele, including pharmaceutical and biotechnology firms, as well as government research agencies and academic institutions, aiming to streamline the drug discovery process by reducing time, cost, and risk associated with screening small molecule compounds against functional human and non-human nuclear receptors.

NanoHorizons Inc. specializes in the invention, design, and manufacturing of nanoscale silver additives that offer antimicrobial protection for a wide range of consumer, commercial, and industrial applications. The company's flagship product, SmartSilver, serves as an antimicrobial additive for bacterial control in materials such as natural and synthetic fibers, coatings, foams, and polymers. NanoHorizons markets its innovative solutions to various industries, including apparel, healthcare, and coatings and plastics, both in the United States and internationally. Founded in 2002 and headquartered in Bellefonte, Pennsylvania, the company combines scientific research with technological advancements to deliver safe, effective, and economical antimicrobial solutions.

Novasentis, Inc. is a company that designs and develops advanced electro-mechanical polymer actuator and sensor technology. Founded in 2006 and headquartered in Berkeley, California, with additional locations in Pennsylvania, Japan, and Korea, Novasentis specializes in creating ultra-thin, flexible haptic actuators and sensors. These innovations are integral to a variety of applications, including keyboards, smartphones, wearable devices, gaming devices, and home appliances. The company's technology enables enhanced sensory interaction, allowing devices to deliver tactile feedback and sound effects that create engaging user experiences. By bridging the gap between consumer electronics and sensory interaction, Novasentis facilitates deeper physical and emotional connections between users and their devices. In June 2019, Novasentis became a subsidiary of KEMET Electronics Corporation.

INRange Systems, Inc. is a company that develops innovative medication delivery systems, primarily focusing on remote medication management. Its flagship product, EMMA, is a telehealth device designed to ensure documented medication administration, particularly for outpatients with a history of non-adherence to their medication regimens. This system allows pharmacists to remotely control and program medication dispensing through a web-based scheduling platform. Additionally, the company offers E-Kit, which provides individual unit dose control for narcotics and non-narcotics, and a Narcotics Control solution that enables long-term care pharmacies to effectively package and dispense medications for patients. Established in 2002 and headquartered in Altoona, Pennsylvania, INRange Systems serves a range of sectors, including independent and assisted living facilities, managed care, skilled nursing facilities, and pharmacies.

SoftGenetics develops software analysis tools tailored for genetic researchers and clinicians, addressing the challenges faced in genetic analysis. Its product lineup includes Mutation Surveyor, which identifies DNA variants from Sanger sequencing traces; NextGENe, a tool that refines and extends short sequence reads; GeneMarker, designed for genotyping with user-friendly defaults to streamline setup; and specialized software for forensic profiling and image analysis. Additionally, CGH Explorer assists in detecting genomic regions with copy number alterations. The company's solutions are aimed at enhancing sensitivity and detail in genetic testing, while minimizing false-positive rates, thereby offering researchers and clinicians effective and accessible analysis options.

Chaperone Tecnologies is developing antimicrobial products, based on a novel and proprietary mechanism of action, for difficult-to-treat and drug-resistant organisms across a broad range of infectious diseases.

INRange Systems, Inc. is a company that develops innovative medication delivery systems, primarily focusing on remote medication management. Its flagship product, EMMA, is a telehealth device designed to ensure documented medication administration, particularly for outpatients with a history of non-adherence to their medication regimens. This system allows pharmacists to remotely control and program medication dispensing through a web-based scheduling platform. Additionally, the company offers E-Kit, which provides individual unit dose control for narcotics and non-narcotics, and a Narcotics Control solution that enables long-term care pharmacies to effectively package and dispense medications for patients. Established in 2002 and headquartered in Altoona, Pennsylvania, INRange Systems serves a range of sectors, including independent and assisted living facilities, managed care, skilled nursing facilities, and pharmacies.

Xbio Systems specializes in providing integrated software solutions tailored for the global Life Sciences sector. The company offers a comprehensive drug development platform that supports both drug and device development by automating workflows and enhancing content management in a secure, web-based environment. Xbio Systems' solutions aim to minimize business risks, improve governance and regulatory compliance, enhance user acceptance, and maximize operational control, all while reducing IT costs.

QuantumBio, Inc. is a software and services company specializing in computer-assisted molecular modeling and drug design solutions tailored for the pharmaceutical, biotechnology, and life sciences sectors. Founded in 2002 and headquartered in State College, Pennsylvania, with additional offices in Gainesville and Lancaster, the company offers a suite of innovative products that employ advanced quantum mechanical approaches. These tools enable scientists to gain precise insights into biochemical structures and functions, thereby enhancing the drug discovery process. By providing high accuracy and versatility, QuantumBio supports researchers in their efforts to develop effective therapeutic solutions.