Life Sciences Greenhouse of Pennsylvania

Avisi Technologies Inc. is a company based in Philadelphia, Pennsylvania, that focuses on developing innovative solutions for glaucoma treatment. Founded in 2017, the company has created VisiPlate, a next-generation aqueous shunt that utilizes nanotechnology to provide a defense against blindness caused by glaucoma. This advanced technology aims to improve the effectiveness of glaucoma treatments and enhance patient outcomes.

Micro Interventional Devices, Inc. is a medical device company focused on developing disruptive technologies for percutaneous and minimally invasive structural heart repair procedures. Founded in 2010 and based in Newtown, Pennsylvania, the company offers a range of innovative products, including the Permaseal device for transapical access and closure, Minimally Invasive Annuloplasty for tricuspid and mitral repair, the Endovalve for percutaneous mitral valve replacement, and the Permavalve, which features active fixation. Their proprietary technology leverages a breakthrough in soft-tissue anchoring and delivery systems, allowing for off-pump procedures that transform traditional open surgical techniques into less invasive transcatheter approaches.

MacuLogix, Inc. specializes in the diagnosis, monitoring, and treatment of age-related macular degeneration (AMD), a leading cause of blindness. The company offers the AdaptDx, a fully automated dark adaptometer designed to aid eye care professionals in detecting and tracking AMD at its earliest stages, potentially up to three years before it becomes visible. This early detection capability allows for timely intervention, which can help prevent vision loss. MacuLogix markets its products through distributors in the United States and internationally, as well as online, to ensure accessibility for healthcare providers. Founded in 2008 and based in Harrisburg, Pennsylvania, MacuLogix is committed to leveraging the science of dark adaptation to combat preventable blindness associated with AMD.

MacuLogix, Inc. specializes in the diagnosis, monitoring, and treatment of age-related macular degeneration (AMD), a leading cause of blindness. The company offers the AdaptDx, a fully automated dark adaptometer designed to aid eye care professionals in detecting and tracking AMD at its earliest stages, potentially up to three years before it becomes visible. This early detection capability allows for timely intervention, which can help prevent vision loss. MacuLogix markets its products through distributors in the United States and internationally, as well as online, to ensure accessibility for healthcare providers. Founded in 2008 and based in Harrisburg, Pennsylvania, MacuLogix is committed to leveraging the science of dark adaptation to combat preventable blindness associated with AMD.

Indigo Biosciences, Inc. is a biosciences company that specializes in developing products and services centered on nuclear receptors, which are important therapeutic drug targets. Founded in 2004 and based in State College, Pennsylvania, the company offers a range of solutions, including receptor assay kits, in vitro toxicology platforms, and custom assay development. Their Live Cell Multiplex assay allows for fluorescence-based quantification of live cells in assay plates. Indigo Biosciences aims to enhance the drug discovery process by providing services that prioritize readability, reproducibility, and expedited results, thus reducing the time, cost, and risk associated with discovering new therapeutics. The company serves clients across various sectors, including pharmaceuticals, biotechnology, food, agriculture, nutraceuticals, and also collaborates with government research agencies and academic institutions.

MacuLogix, Inc. specializes in the diagnosis, monitoring, and treatment of age-related macular degeneration (AMD), a leading cause of blindness. The company offers the AdaptDx, a fully automated dark adaptometer designed to aid eye care professionals in detecting and tracking AMD at its earliest stages, potentially up to three years before it becomes visible. This early detection capability allows for timely intervention, which can help prevent vision loss. MacuLogix markets its products through distributors in the United States and internationally, as well as online, to ensure accessibility for healthcare providers. Founded in 2008 and based in Harrisburg, Pennsylvania, MacuLogix is committed to leveraging the science of dark adaptation to combat preventable blindness associated with AMD.

MacuLogix, Inc. specializes in the diagnosis, monitoring, and treatment of age-related macular degeneration (AMD), a leading cause of blindness. The company offers the AdaptDx, a fully automated dark adaptometer designed to aid eye care professionals in detecting and tracking AMD at its earliest stages, potentially up to three years before it becomes visible. This early detection capability allows for timely intervention, which can help prevent vision loss. MacuLogix markets its products through distributors in the United States and internationally, as well as online, to ensure accessibility for healthcare providers. Founded in 2008 and based in Harrisburg, Pennsylvania, MacuLogix is committed to leveraging the science of dark adaptation to combat preventable blindness associated with AMD.

Micro Interventional Devices, Inc. is a medical device company focused on developing disruptive technologies for percutaneous and minimally invasive structural heart repair procedures. Founded in 2010 and based in Newtown, Pennsylvania, the company offers a range of innovative products, including the Permaseal device for transapical access and closure, Minimally Invasive Annuloplasty for tricuspid and mitral repair, the Endovalve for percutaneous mitral valve replacement, and the Permavalve, which features active fixation. Their proprietary technology leverages a breakthrough in soft-tissue anchoring and delivery systems, allowing for off-pump procedures that transform traditional open surgical techniques into less invasive transcatheter approaches.

Immunomic Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing nucleic acid immunotherapy platforms for the treatment of cancer, allergies, and animal health. Founded in 2005 and based in Rockville, Maryland, with an additional office in South Korea, the company utilizes its UNiversal Intracellular Targeted Expression (UNITE) platform and the LAMP-Vax technology. The LAMP-Vax platform is designed to enhance immune system responses through the presentation of antigens via lysosomal-associated membrane proteins. This innovative approach aims to harness the body's natural biochemistry to promote immune responses, including antibody production and immunological memory, thereby transforming treatment options in the fields of allergy and cancer immunotherapy.

Indigo Biosciences, Inc. is a biosciences company that specializes in developing products and services centered on nuclear receptors, which are important therapeutic drug targets. Founded in 2004 and based in State College, Pennsylvania, the company offers a range of solutions, including receptor assay kits, in vitro toxicology platforms, and custom assay development. Their Live Cell Multiplex assay allows for fluorescence-based quantification of live cells in assay plates. Indigo Biosciences aims to enhance the drug discovery process by providing services that prioritize readability, reproducibility, and expedited results, thus reducing the time, cost, and risk associated with discovering new therapeutics. The company serves clients across various sectors, including pharmaceuticals, biotechnology, food, agriculture, nutraceuticals, and also collaborates with government research agencies and academic institutions.

NanoHorizons Inc. specializes in the invention, design, and manufacture of nanoscale silver additives that deliver antimicrobial protection across a range of consumer, commercial, and industrial applications. Its key product, SmartSilver, is an antimicrobial additive effective in controlling bacteria and is suitable for use in natural and synthetic fibers, fabrics, coatings, foams, and polymer products. The company serves diverse sectors, including apparel, healthcare, and coatings and plastics, catering to both domestic and international markets. Founded in 2002, NanoHorizons is headquartered in Bellefonte, Pennsylvania, and focuses on combining science and technology to create safe and effective nanoparticle solutions.

Novasentis, Inc. specializes in the design and development of electro-mechanical polymer actuator and sensor technology. The company has pioneered the world's first electro-mechanical polymer, which is recognized as the thinnest and most flexible haptic actuator available. This technology is utilized in various applications, including ultra-thin keyboards, smartphones, wearable devices, and gaming devices, enhancing user interaction through localized haptic vibrations and sound effects. By combining consumer electronics with sensory interaction, Novasentis provides innovative solutions that facilitate deeper physical and emotional connections between users and their devices. Founded in 2006 and headquartered in Berkeley, California, Novasentis also maintains offices in Pennsylvania, Japan, and Korea. As of June 2019, it operates as a subsidiary of KEMET Electronics Corporation.

INRange Systems, Inc. specializes in developing medication delivery systems, offering innovative solutions designed to improve medication management. The company's flagship product, EMMA, is a remote medication management system that enables pharmacists to control and program individual unit doses of medication through a web-based platform. Additionally, INRange provides the E-Kit, which manages the dispensing and inventory control of narcotics and non-narcotics, as well as a Narcotics Control solution tailored for long-term care pharmacies. These products are aimed at enhancing medication adherence and safety for patients in independent and assisted living facilities, managed care settings, skilled nursing facilities, and pharmacies. Founded in 2002, INRange Systems is headquartered in Altoona, Pennsylvania.

SoftGenetics develops software analysis tools tailored for genetic researchers and clinicians, addressing the challenges faced in genetic analysis. Its product lineup includes Mutation Surveyor, which identifies DNA variants from Sanger sequencing traces; NextGENe, a tool that refines and extends short sequence reads; GeneMarker, designed for genotyping with user-friendly defaults to streamline setup; and specialized software for forensic profiling and image analysis. Additionally, CGH Explorer assists in detecting genomic regions with copy number alterations. The company's solutions are aimed at enhancing sensitivity and detail in genetic testing, while minimizing false-positive rates, thereby offering researchers and clinicians effective and accessible analysis options.

Chaperone Tecnologies is developing antimicrobial products, based on a novel and proprietary mechanism of action, for difficult-to-treat and drug-resistant organisms across a broad range of infectious diseases.

INRange Systems, Inc. specializes in developing medication delivery systems, offering innovative solutions designed to improve medication management. The company's flagship product, EMMA, is a remote medication management system that enables pharmacists to control and program individual unit doses of medication through a web-based platform. Additionally, INRange provides the E-Kit, which manages the dispensing and inventory control of narcotics and non-narcotics, as well as a Narcotics Control solution tailored for long-term care pharmacies. These products are aimed at enhancing medication adherence and safety for patients in independent and assisted living facilities, managed care settings, skilled nursing facilities, and pharmacies. Founded in 2002, INRange Systems is headquartered in Altoona, Pennsylvania.

Xbio Systems specializes in delivering integrated software solutions tailored for the global Life Sciences sector, focusing on drug and device development. Their offerings include an advanced platform that automates workflows and enhances content management in a secure, web-based environment. By aiming to reduce business risks, improve governance and regulatory compliance, and maximize operational control, Xbio Systems seeks to enhance user acceptance and lower IT costs for its clients.

QuantumBio, Inc. is a software and services company that specializes in computer-assisted molecular modeling and drug design solutions for organizations in the pharmaceutical, biotechnology, and life sciences sectors. Founded in 2002 and headquartered in State College, Pennsylvania, with additional offices in Gainesville and Lancaster, the company offers a suite of innovative products that utilize advanced quantum mechanical approaches. These tools provide high accuracy and versatility, helping scientists to deepen their understanding of biochemical structures and functions. By enhancing the drug discovery process, QuantumBio contributes significantly to the advancement of research in the life sciences.