Medtronic

CathWorks Ltd. is a medical technology company based in Kfar-Saba, Israel, with an additional office in the United States. Founded in 2013, CathWorks specializes in developing advanced medical devices for the interventional cardiology market. The company's innovative technology leverages computational science and automatic multi-layered algorithms to enhance the utility of coronary angiography data, transforming visual assessments into objective decision-making tools for physicians. Its flagship product, CathWorks FFRangio, is a non-invasive device that provides objective multi-vessel physiological measurements, aimed at optimizing and confirming intra-procedural decisions for percutaneous coronary interventions (PCI). CathWorks is privately held and benefits from strong partnerships and support from leading venture capital firms in the medical devices sector.

Beijing Surrey is a technology company founded by an industry elite active in China's medical equipment. Relying on the core technology of the new generation of flexible continuum robotic arm, running through the implementation paradigm of many types of clinical minimally invasive surgery, and harnessing the powerful system design and integration capabilities, Beijing Shurui is committed to becoming the first independent independent research and development, production and sales in China.

Orchestra BioMed, Inc. is a biomedical innovation company established in 2017 and located in New Hope, Pennsylvania. The company is dedicated to developing high-impact therapeutic solutions for medical procedures, with a primary focus on addressing cardiovascular diseases, which account for a significant number of global fatalities annually. Orchestra BioMed aims to accelerate the commercialization of its products through strategic partnerships with medical device companies. Its leading product candidates include BackBeat Cardiac Neuromodulation Therapy, designed for hypertension treatment, and Virtue Sirolimus AngioInfusion Balloon, which targets atherosclerotic artery disease. By emphasizing evidence-based solutions, Orchestra BioMed seeks to improve patient outcomes for serious medical conditions.

Titan Medical Inc. is a research and development stage company based in Toronto, Canada, that specializes in the design and development of robotic surgical technologies for minimally invasive surgery (MIS). The company's primary focus is on the SPORT Surgical System, a single-port robotic surgical system that features a surgeon-controlled patient cart equipped with a 3D high-definition vision system and multi-articulating instruments. This system allows surgeons to perform a variety of MIS procedures, including those related to gynecologic, urologic, colorectal, and abdominal conditions. The SPORT Surgical System includes an ergonomic surgeon workstation that provides a 3D endoscopic view of the surgical area, enhancing the overall surgical experience and precision.

Beijing Surrey is a technology company founded by an industry elite active in China's medical equipment. Relying on the core technology of the new generation of flexible continuum robotic arm, running through the implementation paradigm of many types of clinical minimally invasive surgery, and harnessing the powerful system design and integration capabilities, Beijing Shurui is committed to becoming the first independent independent research and development, production and sales in China.

Rockley Photonics manufactures photonics chips and custom integrated packaged products. It offers products for broad market applications ranging from communications to consumers. The company is focused on sales of chipsets plus the customer-specific design of photonics chips and custom integrated packaged products. In this way, Rockley Photonics leverages its investment in photonics platform research and process development across broader market applications. Rockley Photonics was founded in 2013 and is headquartered in Pasadena, CA.

Intersect ENT, Inc., a drug delivery company, researches and develops products for the treatment of patients with ear, nose, and throat conditions in the United States. The company offers PROPEL and PROPEL mini drug releasing implants for patients undergoing sinus surgery to treat chronic sinusitis; and PROPEL Contour, a steroid releasing implant to frontal and maxillary sinus ostia, or openings, of the dependent sinuses. It also provides SINUVA, a steroid releasing implant for refractory disease for the treatment of patients in the physician office setting. The company was formerly known as Sinexus, Inc. and changed its name to Intersect ENT, Inc. in November 2009. Intersect ENT, Inc. was founded in 2003 and is headquartered in Menlo Park, California.

Scivita Medical is a high-tech enterprise engaged in the field of optical diagnosis and treatment, multidimensional images development, high-performance materials research and precision manufacturing with minimally invasive medical treatment. Scivita Medical's product covers both flexible endoscopy and rigid endoscopy, and has unique advantages in the research and commercialization of all cutting-edge technologies in the field of medical endoscopes. It has ultra-high-definition visualization technology (such as 4K UHD visualization), 3D visualization technology, special light visualization technology (such as fluorescence visualization), ultra-fine endoscopic visualization technology, single-use technology, etc.

BrainsGate, Ltd., a medical device company, develops therapies for patients suffering from central nervous system (CNS) diseases. It offers a technology platform that involves electrical stimulation of the spheno-palatine ganglion (SPG), a nervous center known to increase cerebral blood flow. The company develops an ischemic stroke system that is based on an implantable electrode and is designed to deliver electrical stimulation to the spheno-palatine ganglion (SPG). Its system augments cerebral blood flow by using an external system temporarily attached to the patient’s cheek. BrainsGate, Ltd. was founded in 2000 and is based in Caesarea, Israel.

Ai Biomed is a technology that can detect the location of parathyroid tissue in real-time during surgical procedures, including during thyroidectomy and parathyroidectomy.

Triple Jump Medical is a developer of an insulin pump intended to treat diabetic patients.

BioProtect Ltd. is an international medical device startup. It is primarily engaged in to the business of developing and commercializing biodegradable balloon spacers for the protection of normal tissue during cancer radiation therapy. The company's current focus in the growing radiotherapy spacers market, where its ProSpace balloon spacer (CE marked) has shown superior efficacy and safety in protecting the rectum during radiation therapy for prostate cancer. The company's technology platform of biodegradable implantable balloons suits a wide range of applications for unmet clinical needs. BioProtect was founded in the year 2004 and headquartered in Israel, with subsidiaries in Germany and US.

Companion Medical develops products to improve healthcare with easy-to-use medical devices that utilize state-of-the-art technologies. It has experience in medical devices and critical systems development, and its team is positioned to introduce exciting new medical products that improve and facilitate patient care. The company’s initial products focus on providing improved care to insulin using Diabetics.

Sinovation (Beijing) Medical Technology Co., Ltd. researches, develops, produces, and sells medical devices. The company is based in Beijing, China.

MEDICREA is a fully-dedicated spinal implant company focused on introducing reliable and innovative technologies to the global marketplace. With over 18 years of experience, MEDICREA provides a full range of patented products that are conceived, developed and manufactured to advance patient outcomes and support the work of medical professionals.

Digital Surgery is a privately-held pioneer in surgical artificial intelligence (AI), data and analytics, and digital education and training.

Stimgenics is a private company that pioneered a novel spinal cord stimulation waveform known as Differential Target Multiplexed (DTM) Spinal Cord Stimulation.

Klue, Inc. is a digital health technology company founded in 2016 and based in San Mateo, California. It specializes in developing artificial intelligence-based software that can recognize meals and analyze users' eating behaviors. Klue's innovative approach includes wearable technology aimed at addressing obesity by promoting healthier eating habits through real-time behavioral insights. As a subsidiary of Medtronic plc, Klue focuses on leveraging technology to empower individuals to make informed dietary choices and cultivate better eating patterns.

AV Medical is a company of medical devices that develops catheter-based interventions. It targets its flagship catheter, the Chameleon, to dialysis patients undergoing routine angioplasty procedures. It develops and commercializes the Chameleon PTA balloon catheter with its Supervision technology. The Chameleon catheter facilitates efficient angioplasty procedures and can potentially enhance both patient and operator safety. Experts have clinically he Chameleon has been clinically tested in various types of dialysis access procedures.

Saluda Medical Pty Ltd., established in 2013 and headquartered in Artarmon, Australia, focuses on developing innovative medical devices for the neuromodulation industry. The company's flagship product, Evoke, is an investigational closed-loop spinal cord stimulation system designed to measure and adapt to the spinal cord's response to stimulation. By adjusting the stimulation on every pulse, Evoke aims to optimize therapeutic outcomes for patients within their individualized treatment parameters. Saluda Medical's foundation is built on years of research from Australia's NICTA and is supported by a team of experienced engineers, clinicians, and professionals dedicated to advancing medical technologies. The company also has offices in Bloomington, Minnesota, and Harrogate, United Kingdom.

Titan Spine designs and manufactures interbody fusion devices for use in the cervical and lumbar spine. It offers Endoskeleton TL, a lateral fusion device for the lumbar spine; Endoskeleton TAS, an anterior lumbar interbody fusion (ALIF) interbody device with screws; Endoskeleton TA, a device for ALIF procedures; Endoskeleton TT, a device for transforaminal lumbar interbody fusion (TLIF) procedures; Endoskeleton TO, a device for posterior lumbar interbody fusion (PLIF) and oblique procedures; Endoskeleton TCS, a cervical interbody device with screws for anterior discectomy and fusion (ACDF); and Endoskeleton TC, a device for anterior discectomy and fusion (ACDF) procedures. Titan Spine serves patients in the United States and Europe through its sales force and a network of independent distributors. It has a strategic partnership with MBA. Kevin Gemas and Peter Ullrich founded Titan Spine in 2006. It has its headquarters in Mequon in Wisconsin with a location in Laichingen in Germany.

EPIX Therapeutics develops and manufactures products for use in electrophysiology based on microwave radiometry technology. Its products provide real-time feedback of energy delivered by catheters during cardiac ablation procedures. The company has a strategic relationship with Hansen Medical Inc. Advanced Cardiac Therapeutics, Inc. (ACT), a medical device company that designs and manufactures a catheter-based system for the treatment of patients with atrial fibrillation (AFIB), today announced it has changed its name to EPIX Therapeutics, Inc.

Nutrino Health Ltd. develops a nutrition insights software platform that offers nutrition-related data services and analytics. The company offers FoodPrint, a personalized recommendation software that offers meal suggestions and health statistics. It serves individuals, businesses, and professionals. The company was founded in 2011 and is based in Tel Aviv, Israel. As of November 21, 2018, Nutrino Health Ltd. operates as a subsidiary of Medtronic plc.

Mazor Robotics Ltd. specializes in the development and marketing of medical devices that enhance surgical procedures, particularly in orthopedics and neurosurgery. The company is recognized for its innovative Renaissance Guidance System, which transforms traditional spine surgeries into highly accurate, minimally invasive procedures. This system, along with complementary products, supports surgeons in performing complex operations with greater precision and safety, ultimately improving patient outcomes. Founded in 2000 and headquartered in Caesarea, Israel, Mazor Robotics aims to raise the standard of care in the operating room by offering advanced technologies that streamline surgical processes.

MC10, Inc. specializes in developing and selling wearable medical sensors that capture clinical-grade biometric and physiological data for use in clinical trials. Founded in 2008 and based in Lexington, Massachusetts, the company offers several innovative products, including BioStamp nPoint, which processes raw data into clinical metrics such as vital signs and sleep patterns; Kintinuum, a rehabilitation device for orthopedic surgery; WiSP, which provides cardiac monitoring and ECG recording; and BioStampMD, a flexible sensor designed to conform to the human body for comprehensive data collection. The BioStamp system enhances data acquisition by allowing for discreet and comfortable wear, thus facilitating targeted measurements of muscle activation and movement. MC10's dedication to creating flexible, conformal electronics aims to improve the quality of life by seamlessly integrating technology with human activity.

Nanos Medical is engaged in the research and development, manufacturing and sales of disposable medical devices. The company's current core products are concentrated in the cardiovascular and ENT fields.

Yosemite Clinic is a full-service clinic providing convenient walk-in medical services in a state-of-the-art environment in Central Pudong. They offer family medicine, internal medicine, surgery, orthopedics (sports medicine), dermatology, medical cosmetology, dentistry, gynecology, pediatrics, ophthalmology, anesthesiology, rehabilitation medicine, medical imaging, laboratory, pharmacy and more. Their onsite facilities and equipment include CT, X-ray, Ultrasound, Laboratory and Operating Rooms. Their doctors come from China and across the world, enabling us to serve you in many languages including, English, Japanese, Malay, Mandarin Chinese and Cantonese.

VisionSense Corp. designs and develops advanced 3D-HD visualization systems specifically for minimally invasive surgeries. Its flagship products include the Visionsense VSiii system, which utilizes a stereoscopic camera for various surgical applications such as neurosurgery, ENT procedures, arthroscopy, and laparoscopy. Additionally, the Visionsense Iridium system provides inter-operative infrared fluorescence visualization to enhance surgical precision. The company's innovative technology offers depth perception and high-resolution imaging, allowing surgeons to navigate complex procedures with greater confidence and control. VisionSense serves medical centers globally, focusing on areas including neurosurgery, plastic and reconstructive surgery, and tumor margin visualization. Founded in 1998 and headquartered in Philadelphia, Pennsylvania, VisionSense operates additional offices in New York and Petah-Tikva, Israel, and functions as a subsidiary of Medtronic plc.

Fire1, based in Dublin, Ireland, is dedicated to developing innovative therapeutic devices aimed at enhancing the lives of heart failure patients. The company has created a remote monitoring system that allows healthcare providers to access real-time patient data and insights. This technology facilitates the early detection of complications associated with heart failure, enabling proactive interventions that can lead to improved patient outcomes. Through its focus on remote monitoring, Fire1 seeks to address critical challenges in heart failure management and contribute to better healthcare solutions.

AEGEA Medical is pioneering the application of its Adaptive Vapor Ablation technology to deliver therapies that provide high quality patient outcomes to a wider range of patients. AEGEA’s FDA approved water vapor technology enables the delivery of a safe and effective endometrial ablation for the treatment of menorrhagia in a simple, office-based procedure that takes only minutes. With a vision to expand safe and effective treatment options to more patients, and provide physicians with the confidence and convenience necessary to perform office-based procedures, AEGEA is inspiring new approaches to women’s healthcare. Founded in 2008, AEGEA Medical is located in in Menlo Park, California.

Crospon is developing edge minimally invasive medical devices for imaging and aiding surgery in the esophagus and stomach.

Semma Therapeutics, Inc. is focused on developing innovative cell therapies for patients with Type 1 diabetes, aiming to provide alternatives to insulin injections. The company emerged from research by Professor Douglas Melton, which led to the discovery of a method for generating billions of functional, insulin-producing beta cells in the laboratory. This breakthrough technology has been exclusively licensed to Semma Therapeutics, which is now dedicated to creating a cell-based therapy that combines these proprietary cells with advanced devices to effectively replace the missing beta cells in diabetic patients without the need for immunosuppression. Established in 2014 and headquartered in Cambridge, Massachusetts, Semma Therapeutics operates as a subsidiary of Vertex Pharmaceuticals and is committed to bringing its novel therapeutic solutions to clinical settings, ultimately enhancing the quality of life for individuals living with diabetes.

Mazor Robotics Ltd. specializes in the development and marketing of medical devices that enhance surgical procedures, particularly in orthopedics and neurosurgery. The company is recognized for its innovative Renaissance Guidance System, which transforms traditional spine surgeries into highly accurate, minimally invasive procedures. This system, along with complementary products, supports surgeons in performing complex operations with greater precision and safety, ultimately improving patient outcomes. Founded in 2000 and headquartered in Caesarea, Israel, Mazor Robotics aims to raise the standard of care in the operating room by offering advanced technologies that streamline surgical processes.

SetPoint Medical Corporation, a clinical-stage bioelectronic medicine company, develops implantable neuromodulation devices for treating patients with debilitating inflammatory diseases. SetPoint Medical Corporation was formerly known as Innovative Metabolics Inc. and changed its name to SetPoint Medical Corporation in July 2008. The company was incorporated in 2006 and is based in Valencia, California.

Glooko is the universal diabetes platform that provides insights to improve outcomes for people with diabetes (PWDs) and their care teams. Glooko connects to the world’s most popular diabetes devices, major fitness and activity trackers and supplies personalized, timely patient information such as glucose level, food, insulin, medications, blood pressure, diet and weight data. Trusted by the world’s leaders in diabetes care, we are in over 7,000 clinical locations and used by over 1.5 million PWDs in 23 countries across 15 languages. Learn more by visiting www.glooko.com.

Earlens is a privately held medical technology company committed to transforming the hearing experience for millions of people who suffer from hearing loss.The company has developed the Earlens Contact Hearing Solution, which directly activates natural hearing, delivering the broadest bandwidth available today and superior sound quality. This revolutionary, non-surgical hearing solution uses a small lens to vibrate the eardrum, replicating the natural hearing process. The Earlens Contact Hearing Solution received FDA clearance in 2019 for a second generation of the Earlens technology. Unlike traditional hearing aids, which are in effect tiny speakers that simply turn up the volume on air conducted sound, the Earlens Contact Hearing Solution™ is the world’s first to deliver sound directly to the eardrum.

Saluda Medical Pty Ltd., established in 2013 and headquartered in Artarmon, Australia, focuses on developing innovative medical devices for the neuromodulation industry. The company's flagship product, Evoke, is an investigational closed-loop spinal cord stimulation system designed to measure and adapt to the spinal cord's response to stimulation. By adjusting the stimulation on every pulse, Evoke aims to optimize therapeutic outcomes for patients within their individualized treatment parameters. Saluda Medical's foundation is built on years of research from Australia's NICTA and is supported by a team of experienced engineers, clinicians, and professionals dedicated to advancing medical technologies. The company also has offices in Bloomington, Minnesota, and Harrogate, United Kingdom.

Semma Therapeutics, Inc. is focused on developing innovative cell therapies for patients with Type 1 diabetes, aiming to provide alternatives to insulin injections. The company emerged from research by Professor Douglas Melton, which led to the discovery of a method for generating billions of functional, insulin-producing beta cells in the laboratory. This breakthrough technology has been exclusively licensed to Semma Therapeutics, which is now dedicated to creating a cell-based therapy that combines these proprietary cells with advanced devices to effectively replace the missing beta cells in diabetic patients without the need for immunosuppression. Established in 2014 and headquartered in Cambridge, Massachusetts, Semma Therapeutics operates as a subsidiary of Vertex Pharmaceuticals and is committed to bringing its novel therapeutic solutions to clinical settings, ultimately enhancing the quality of life for individuals living with diabetes.

Forerunner Medical (Shanghai) Co., Ltd. develops and manufactures medical devices for minimally invasive treatment. It primarily develops and produces low-temperature plasma radiofrequency generators and electrodes for sport medicine, disk demo-pression, and ENT treatment applications. Its products include plasma radiofrequency systems; and electrodes for joint, spine, cervical, lumbar, transforaminal endoscopic operation, and ENT treatment applications. The company was founded in 2009 and is based in Shanghai, China.

Inspire Medical Systems, Inc., a medical technology company, focuses on the development and commercialization of minimally invasive solutions for patients with obstructive sleep apnea (OSA). It offers Inspire system, a neurostimulation technology that provides a safe and effective treatment for moderate to severe OSA. The company also develops a novel, a closed-loop solution that continuously monitors a patient’s breathing and delivers mild hypoglossal nerve stimulation to maintain an open airway. Inspire Medical Systems, Inc. was founded in 2007 and is headquartered in Golden Valley, Minnesota.

MD Start SA offers fund placement services to medical device start-up corporations. It has partnerships with Medtronic, Sofinnova Partners, Sorin Group, Versant Ventures, Contract Medical International, and Corscience GmbH & Co. KG. The company, formerly known as Medical Device Accelerator, was founded in 2009 and is based in Lausanne, Switzerland.

Mazor Robotics Ltd. specializes in the development and marketing of medical devices that enhance surgical procedures, particularly in orthopedics and neurosurgery. The company is recognized for its innovative Renaissance Guidance System, which transforms traditional spine surgeries into highly accurate, minimally invasive procedures. This system, along with complementary products, supports surgeons in performing complex operations with greater precision and safety, ultimately improving patient outcomes. Founded in 2000 and headquartered in Caesarea, Israel, Mazor Robotics aims to raise the standard of care in the operating room by offering advanced technologies that streamline surgical processes.

HeartWare International, Inc. develops and manufactures small implantable heart pumps or ventricular assist devices for the treatment of advanced heart failure. The company offers HeartWare Ventricular Assist System, which includes a left ventricular assist device, or blood pump, patient accessories, and surgical tools designed to provide circulatory support for patients in the advanced stage of heart failure. It is also developing the Miniaturized Ventricular Assist Device, a miniaturized device intended for chronic heart failure patients. HeartWare International, Inc. sells and markets its products through clinical studies in the United States, as well as directly to cardiac centers and hospitals internationally. The company is headquartered in Framingham, Massachusetts.

Earlens is a privately held medical technology company committed to transforming the hearing experience for millions of people who suffer from hearing loss.The company has developed the Earlens Contact Hearing Solution, which directly activates natural hearing, delivering the broadest bandwidth available today and superior sound quality. This revolutionary, non-surgical hearing solution uses a small lens to vibrate the eardrum, replicating the natural hearing process. The Earlens Contact Hearing Solution received FDA clearance in 2019 for a second generation of the Earlens technology. Unlike traditional hearing aids, which are in effect tiny speakers that simply turn up the volume on air conducted sound, the Earlens Contact Hearing Solution™ is the world’s first to deliver sound directly to the eardrum.

Responsive Orthopedics is a start-up focused on sales of low-cost hip and knee replacements. Its products are intended exclusively for healthcare providers participating in federal programs to reduce the costs of hip and knee procedures. The company was founded in 2013 and is based in Minneapolis. In June 2016, Responsive Orthopedics was acquired by [Medtronic](/organization/medtronic).

Gynaecology has been rapidly built around Smith & Nephew's resection technologies and comprises, primarily, the TRUCLEAR◊ System for the hysteroscopic resection and removal of uterine tissue. Gynaecology delivered revenue of $56 million in 2015, representing a little over 1% of Group revenue.

Bellco, an Italian company with a European identity, is one of the pioneers and protagonists of haemodialysis. Now, just as in the past, it focuses on satisfying the needs of patients and experts through innovation, research and the development of advanced Nephrology, Intensive Care and Cardiology therapies.

Aircraft Medical Limited develops and produces hand held medical devices. It offers McGRATH, a portable video laryngoscope. The company specializes in anesthesia and critical care products. It markets its products through distribution partners in the United States, Canada, the United Kingdom, Ireland, Italy, France, Denmark, Sweden, Norway, Benelux, and Australasia. Aircraft Medical Limited was formerly known as Smartscope MD Ltd. and changed its name to Aircraft Medical Limited in February 2004. The company was founded in 2001 and is based in Edinburgh, the United Kingdom. As of November 18, 2015, Aircraft Medical Limited operates as a subsidiary of Medtronic plc.

Lazarus Effect, a medical device company focused on the development of novel Interventional devices to facilitate removal of blood clots. Lazarus Effect is developing a complete portfolio of vascular-device products to facilitate removal of blood clots based on a patented, wire-frame technology platform. The company currently has five issued US patents and numerous pending US and worldwide patent applications. The Lazarus Funnel™ Guide Catheter and Lazarus ReCover devices have CE Mark for use in Europe, and the Funnel is cleared for use in the United States. The Lazarus Cover is pending CE Mark. Neither the ReCover nor the Cover are approved for sale in the United States.

SetPoint Medical Corporation, a clinical-stage bioelectronic medicine company, develops implantable neuromodulation devices for treating patients with debilitating inflammatory diseases. SetPoint Medical Corporation was formerly known as Innovative Metabolics Inc. and changed its name to SetPoint Medical Corporation in July 2008. The company was incorporated in 2006 and is based in Valencia, California.

Medtronic is a healthcare technology company focused on developing innovative solutions for chronic diseases. Founded in 1949 and headquartered in Minneapolis, Minnesota, Medtronic operates through four main business units: the Minimally Invasive Therapies Group, the Diabetes Group, the Restorative Therapies Group, and the Cardiac and Vascular Group. The company manufactures a wide range of medical devices and therapies aimed at treating over 30 chronic conditions, including heart failure, Parkinson's disease, urinary incontinence, obesity, chronic pain, spinal disorders, and diabetes. Medtronic also owns Medina Medical Inc., which specializes in minimally invasive devices for treating brain aneurysms and strokes. Through its products and services, Medtronic is dedicated to improving patients' lives and providing lifelong solutions for those suffering from chronic health issues.

Twelve manufactures medical devices. It was formerly known as Foundry Newco XII, Inc. The company was incorporated in 2009 and is based in Menlo Park, California.

RF Surgical Systems, Inc. is the market leader in the detection and prevention of retained surgical sponges. The RF Surgical Detection System is the preferred solution in more than 1,500 operating rooms, trauma and labor and delivery suites nationwide. Since January 2011, more than 70 hospitals and surgical centers have joined the fast-growing list of care providers using RF Surgical Technology. RF Surgical Systems is based in Bellevue, Washington with R & D facilities in San Diego, California. The advanced technologies used in the RF Surgical Detection System are protected by U.S. patents. Regulatory clearance to market the system was granted by the U.S. Food and Drug Administration in November 2006.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, specializing in non-invasive cardiac mapping systems. The company has developed a technology known as Electrocardiographic Mapping (ECM), which produces three-dimensional images of the heart's electrical activity. This innovative system integrates body surface electrical data with anatomical data from CT scans, allowing for real-time visualization of cardiac electrical activity. The process involves the use of a single-use, disposable multi-sensor vest that captures electrical signals from the body, which are then processed by software to create detailed epicardial 3D electroanatomic maps and virtual electrograms. CardioInsight's technology aims to enhance the accuracy of diagnosing and treating various heart conditions, particularly arrhythmias and congestive heart failure. The effectiveness of ECM has been validated through more than 260 patient studies. Since 2015, CardioInsight has operated as a subsidiary of Medtronic plc.

Aptus Endosystems, Inc. is a medical device company focused on developing, manufacturing, and distributing innovative solutions for endovascular aneurysm repair (EVAR). Established in 2002 and headquartered in Sunnyvale, California, the company specializes in advanced technologies for treating aortic aneurysms, particularly through its Heli-FX EndoAnchor system, which provides a durable alternative to open surgical repair. This system utilizes unique helical staple technology for effective endograft fixation, enabling minimally invasive treatment options that maintain the control associated with open surgery. Aptus also offers the Aptus TourGuide, a steerable sheath designed for efficient access and delivery of peripheral vascular products. The company's products are available in several countries, including the United States, Germany, Italy, the Netherlands, and the United Kingdom, primarily through distributors.

AEGEA Medical is pioneering the application of its Adaptive Vapor Ablation technology to deliver therapies that provide high quality patient outcomes to a wider range of patients. AEGEA’s FDA approved water vapor technology enables the delivery of a safe and effective endometrial ablation for the treatment of menorrhagia in a simple, office-based procedure that takes only minutes. With a vision to expand safe and effective treatment options to more patients, and provide physicians with the confidence and convenience necessary to perform office-based procedures, AEGEA is inspiring new approaches to women’s healthcare. Founded in 2008, AEGEA Medical is located in in Menlo Park, California.

Ortho Kinematics is a spine diagnostics company based in Austin, Texas, that specializes in spine motion analysis and diagnostic services. Founded in 2006, the company develops advanced healthcare diagnostic technology solutions focused on spine imaging informatics. Its primary offering, the KineGraph Vertebral Motion Analyzer, employs fluoroscopy to capture and analyze the motion of the spine, generating patient-specific graphs that aid clinicians in diagnosing and treating back and neck pain. Additionally, Ortho Kinematics provides cloud-based results for instability testing and video X-ray images of spinal motion. The company also operates an imaging center in Austin, further supporting its commitment to improving spinal diagnostics.

DreaMed Diabetes, Ltd. is an Israeli company founded in 2014 that specializes in developing innovative solutions for diabetes treatment and management. The company is known for its Glucositter, a closed-loop insulin delivery system designed to monitor glucose levels in real-time and adjust insulin delivery accordingly. DreaMed Diabetes has made significant advancements in the field, including the commercialization of the first artificial pancreas technology and becoming the first company to receive FDA clearance for a decision support system that integrates data from continuous glucose monitors and insulin pumps. Its Advisor Pro software, developed by diabetes professionals, utilizes artificial intelligence to enable healthcare providers to quickly analyze patient data and recommend optimal treatment plans. This technology facilitates frequent insulin titration adjustments and online monitoring, ultimately improving patient outcomes by lowering A1C levels and reducing complications. DreaMed Diabetes aims to provide patient-centered care, ensuring that all individuals with diabetes receive high-quality treatment regardless of their location or healthcare provider.

Diabeter B.V. is a diabetes clinic and research center located in Rotterdam, the Netherlands. The organization focuses on providing specialized care for individuals with diabetes, employing innovative approaches to treatment and management. Since April 2015, Diabeter has operated as a subsidiary of Medtronic, a global leader in medical technology. Through its clinical and research activities, Diabeter aims to improve diabetes care and outcomes for patients, contributing to advancements in diabetes management.

Sophono, Inc. develops and manufactures magnetic bone conduction hearing devices for patients with conductive hearing loss, mixed hearing loss, and single-sided deafness worldwide. It offers Alpha 2 MPO, a bone conduction hearing device that brings abutment-free bone conduction for the patients that lies under the skin. The company sells its products through clinics. The company was founded in 2009 and is based in Boulder, Colorado. As of March 26, 2015, Sophono, Inc. operates as a subsidiary of Medtronic plc.

Semma Therapeutics, Inc. is focused on developing innovative cell therapies for patients with Type 1 diabetes, aiming to provide alternatives to insulin injections. The company emerged from research by Professor Douglas Melton, which led to the discovery of a method for generating billions of functional, insulin-producing beta cells in the laboratory. This breakthrough technology has been exclusively licensed to Semma Therapeutics, which is now dedicated to creating a cell-based therapy that combines these proprietary cells with advanced devices to effectively replace the missing beta cells in diabetic patients without the need for immunosuppression. Established in 2014 and headquartered in Cambridge, Massachusetts, Semma Therapeutics operates as a subsidiary of Vertex Pharmaceuticals and is committed to bringing its novel therapeutic solutions to clinical settings, ultimately enhancing the quality of life for individuals living with diabetes.

Glooko is the universal diabetes platform that provides insights to improve outcomes for people with diabetes (PWDs) and their care teams. Glooko connects to the world’s most popular diabetes devices, major fitness and activity trackers and supplies personalized, timely patient information such as glucose level, food, insulin, medications, blood pressure, diet and weight data. Trusted by the world’s leaders in diabetes care, we are in over 7,000 clinical locations and used by over 1.5 million PWDs in 23 countries across 15 languages. Learn more by visiting www.glooko.com.

Advanced Uro-Solutions develops and manufactures the NURO percutaneous tibial nerve stimulation system, which consists of a small external stimulator and a single, reusable lead to provide temporary stimulation to the tibial nerve.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to assist presbyopic patients in restoring their near vision while preserving distance clarity. Additionally, AcuFocus provides the IC-8 IOL, a small aperture lens that accommodates a range of vision for cataract patients. The AcuTarget HD system serves as a diagnostic and surgical planning tool, aiding in the optimal treatment selection for various eye conditions, including LASIK and dry eye. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, thereby serving a global clientele of physicians and patients. Founded in 2001, AcuFocus continues to focus on advancing solutions for presbyopia and related vision issues.

Founded by Dr. Eugenio Cremascoli, the main business of NGC Medical Focuses are: Project planning, manufacturing and marketing of medical and surgical devices Import and distribution in national territory of medical devices, medical data management systems, medical communications database for remote access and medical equipment Design and turnkey implementation of Surgery Units, Intensive Care, Hemodynamics, Electrophysiology and Intervention Radiology Laboratories In-service management of Surgical Suites, Intensive Care, Hemodynamics, Electrophysiology and Intervention Radiology Laboratories Design and implementation of Information Management Software packages unifying the administrative and clinical departments within at single interface

Sapiens Steering Brain Stimulation GmbH is an emerging medical device company whose mission is to deliver superior solutions for deep brain stimulation (DBS) therapy. Sapiens' ambition is to provide a unique, high-resolution, and MRI- compatible DBS system that will improve patient comfort and therapeutic outcome, initially for patients with Parkinson's disease. Sapiens, with offices in Eindhoven, the Netherlands and Munich, Germany, is founded in 2011 as a spin-out of Royal Philips Electronics. Its steering brain stimulation (SBS) system and image-guided programming are based upon patented technologies.

Visualase, Inc. was founded in 2005 as a spin-off from BioTex, Inc., the original developer and current manufacturer of the Visualase technology. Visualase, Inc. is currently a privately held company located in Houston, Texas.

Covidien plc is a global leader in healthcare products, focusing on the development, manufacture, and sale of a wide range of medical supplies and devices for both clinical and home environments. The company operates through four primary segments: Medical Devices, Imaging Solutions, Pharmaceutical Products, and Medical Supplies. The Medical Devices segment includes endomechanical instruments, soft tissue repair products, energy devices, oximetry and monitoring products, airway and ventilation products, vascular devices, and clinical care products. Imaging Solutions involves the production of radiopharmaceuticals and contrast products. The Pharmaceutical Products segment encompasses the development and distribution of dosage pharmaceuticals and active pharmaceutical ingredients. Lastly, the Medical Supplies segment covers nursing care products, surgical products, and original equipment manufacturer products. Through this diverse portfolio, Covidien aims to enhance patient care and support healthcare professionals worldwide.

Corventis is committed to improving clinical outcomes and lowering healthcare costs by enabling the early detection of cardiovascular events while allowing patients to maintain an active lifestyle.

Inspire Medical Systems, Inc., a medical technology company, focuses on the development and commercialization of minimally invasive solutions for patients with obstructive sleep apnea (OSA). It offers Inspire system, a neurostimulation technology that provides a safe and effective treatment for moderate to severe OSA. The company also develops a novel, a closed-loop solution that continuously monitors a patient’s breathing and delivers mild hypoglossal nerve stimulation to maintain an open airway. Inspire Medical Systems, Inc. was founded in 2007 and is headquartered in Golden Valley, Minnesota.

PowerVision, Inc. is a company that specializes in the development of innovative accommodating intraocular lens technology aimed at restoring vision for individuals affected by presbyopia and cataracts. Based in Belmont, California, PowerVision's flagship product, the FluidVision intraocular lens, utilizes a small amount of fluid within the lens to mimic the natural functioning of a healthy eye, allowing users to dynamically adjust their focus for clear vision at all distances. This technology is designed to address the vision needs of millions, particularly the elderly, who suffer from cataracts and the age-related loss of near vision associated with presbyopia. By offering a solution that potentially eliminates the need for glasses or other forms of vision correction, PowerVision aims to significantly improve the quality of life for those facing these common age-related vision challenges. The company was incorporated in 2002 and was acquired by Alcon Laboratories, Inc. in March 2019.

TyRx engages in the design, development, and commercialization of resorbable polymeric biomaterials. It offers PIVIT CRM, a mesh based pouch, which contains antibacterial agents to help provide protection from microbial colonization of the generator or defibrillator during and immediately after surgical implant. The company also provides AIGISRx Flat, an antibacterial product that provides protection against infections associated with implanted pacemakers and defibrillators. TyRx Pharma, Inc. was formerly known as Advanced Materials Design, LLC. The company was founded in 1997 and is based in Monmouth Junction, New Jersey.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, specializing in non-invasive cardiac mapping systems. The company has developed a technology known as Electrocardiographic Mapping (ECM), which produces three-dimensional images of the heart's electrical activity. This innovative system integrates body surface electrical data with anatomical data from CT scans, allowing for real-time visualization of cardiac electrical activity. The process involves the use of a single-use, disposable multi-sensor vest that captures electrical signals from the body, which are then processed by software to create detailed epicardial 3D electroanatomic maps and virtual electrograms. CardioInsight's technology aims to enhance the accuracy of diagnosing and treating various heart conditions, particularly arrhythmias and congestive heart failure. The effectiveness of ECM has been validated through more than 260 patient studies. Since 2015, CardioInsight has operated as a subsidiary of Medtronic plc.

Cardiocom is the leader in telemedicine solutions for daily remote patient monitoring and disease management. Cardiocom provides health professionals with home telemonitoring equipment and telehealth services to identify symptomatic patients and intervene early to prevent unnecessary hospitalizations. Cardiocom addresses CHF, COPD, Asthma, Diabetes, Hypertension and Obesity. We offer a variety of health monitoring product and service options to meet your organization's specific needs. Cardiocom can provide in-house case managers with the Cardiocom OMNIVISOR PRO® Patient Management System, TELESCALE® for CHF management and COMMANDER for complex patients with multiple diseases. Cardiocom's proven, proactive solutions for daily patient disease management result in improved quality of life and direct savings to the health management group.

MC10, Inc. specializes in developing and selling wearable medical sensors that capture clinical-grade biometric and physiological data for use in clinical trials. Founded in 2008 and based in Lexington, Massachusetts, the company offers several innovative products, including BioStamp nPoint, which processes raw data into clinical metrics such as vital signs and sleep patterns; Kintinuum, a rehabilitation device for orthopedic surgery; WiSP, which provides cardiac monitoring and ECG recording; and BioStampMD, a flexible sensor designed to conform to the human body for comprehensive data collection. The BioStamp system enhances data acquisition by allowing for discreet and comfortable wear, thus facilitating targeted measurements of muscle activation and movement. MC10's dedication to creating flexible, conformal electronics aims to improve the quality of life by seamlessly integrating technology with human activity.

Kanghui was founded in 1997 and is headquartered in Changzhou. Kanghui announced today that it requested that trading of its American depositary shares on the NYSE be suspended. Kanghui has requested that the NYSE file Form 25 with the U.S. Securities and Exchange Commission (the “SEC”) notifying the SEC of the delisting of Kanghui’s American depositary shares from NYSE and the deregistration of the Company’s registered securities. Kanghui intends to terminate its reporting obligations under the Securities Exchange Act of 1934, as amended by promptly filing Form 15 with the SEC.

Mitralign is a venture backed privately held company located in a suburb of Boston, MA. The company is developing an innovative catheter based technology for percutaneous treatment of functional mitral regurgitation. The novel Mitralign system emulates surgical annuloplasty as it delivers a series of surgical implants directly into the mitral annulus by means of a catheter. The implants are cinched together, thus reducing the size of the mitral valve annulus and the valve opening. Mitralign is funded by top tier venture capitalists and has two major cardiovascular device companies as investors.

Inspire Medical Systems, Inc., a medical technology company, focuses on the development and commercialization of minimally invasive solutions for patients with obstructive sleep apnea (OSA). It offers Inspire system, a neurostimulation technology that provides a safe and effective treatment for moderate to severe OSA. The company also develops a novel, a closed-loop solution that continuously monitors a patient’s breathing and delivers mild hypoglossal nerve stimulation to maintain an open airway. Inspire Medical Systems, Inc. was founded in 2007 and is headquartered in Golden Valley, Minnesota.

Visualase, Inc. was founded in 2005 as a spin-off from BioTex, Inc., the original developer and current manufacturer of the Visualase technology. Visualase, Inc. is currently a privately held company located in Houston, Texas.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, specializing in non-invasive cardiac mapping systems. The company has developed a technology known as Electrocardiographic Mapping (ECM), which produces three-dimensional images of the heart's electrical activity. This innovative system integrates body surface electrical data with anatomical data from CT scans, allowing for real-time visualization of cardiac electrical activity. The process involves the use of a single-use, disposable multi-sensor vest that captures electrical signals from the body, which are then processed by software to create detailed epicardial 3D electroanatomic maps and virtual electrograms. CardioInsight's technology aims to enhance the accuracy of diagnosing and treating various heart conditions, particularly arrhythmias and congestive heart failure. The effectiveness of ECM has been validated through more than 260 patient studies. Since 2015, CardioInsight has operated as a subsidiary of Medtronic plc.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to assist presbyopic patients in restoring their near vision while preserving distance clarity. Additionally, AcuFocus provides the IC-8 IOL, a small aperture lens that accommodates a range of vision for cataract patients. The AcuTarget HD system serves as a diagnostic and surgical planning tool, aiding in the optimal treatment selection for various eye conditions, including LASIK and dry eye. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, thereby serving a global clientele of physicians and patients. Founded in 2001, AcuFocus continues to focus on advancing solutions for presbyopia and related vision issues.

Functional Neuromodulation is a medical technology company that specializes in developing neuromodulation therapies aimed at treating Alzheimer's disease and other cognitive disorders. Established in 2010, the company is headquartered in Toronto, Canada, with an additional office in Minneapolis, Minnesota. Its primary offering is a deep brain stimulation (DBS) technology, which involves a surgically implanted device that delivers mild electrical pulses to specific areas of the brain. This approach is designed to enhance neural activity and modulate memory circuits, ultimately assisting patients in managing symptoms associated with memory and cognitive impairments. Through its innovative therapies, Functional Neuromodulation aims to improve the quality of life for individuals suffering from these challenging conditions.

PowerVision, Inc. is a company that specializes in the development of innovative accommodating intraocular lens technology aimed at restoring vision for individuals affected by presbyopia and cataracts. Based in Belmont, California, PowerVision's flagship product, the FluidVision intraocular lens, utilizes a small amount of fluid within the lens to mimic the natural functioning of a healthy eye, allowing users to dynamically adjust their focus for clear vision at all distances. This technology is designed to address the vision needs of millions, particularly the elderly, who suffer from cataracts and the age-related loss of near vision associated with presbyopia. By offering a solution that potentially eliminates the need for glasses or other forms of vision correction, PowerVision aims to significantly improve the quality of life for those facing these common age-related vision challenges. The company was incorporated in 2002 and was acquired by Alcon Laboratories, Inc. in March 2019.

PEAK Surgical is a medical device company based in Palo Alto, California, specializing in advanced surgical tools that combine the precision of a scalpel with effective bleeding control akin to traditional electrosurgery. Its innovative PEAK Surgery System is designed to minimize collateral damage during surgical procedures, addressing a significant need in the medical market. The system has received clearance for use in a variety of surgical disciplines, including general, plastic and reconstructive, ENT, gynecologic, orthopedic, arthroscopic, spinal, and neurological surgeries in the United States, as well as for general surgery in the European Union.

Established in 1999, Salient Surgical Technologies, Inc. is a global, privately held medical technology company that develops and markets advanced energy devices used in surgical procedures. Salient’s first line of products were monopolar electrosurgical devices used for the treatment of liver cancers. Today, the company’s bipolar AQUAMANTYS® System is used across a wide range of surgical procedures including orthopaedic reconstruction, spine surgery, orthopaedic trauma, and surgical oncology. Comprised of a bipolar electrosurgical generator & pump system and a portfolio of handheld disposable device, the AQUAMANTYS system uses patented TRANSCOLLATION® technology to haemostatically seal soft tissue and bone, enabling surgeons to reduce and prevent surgical blood loss. Salient’s products are sold throughout the United States, Europe, and Asia, providing clinical and economic benefits to hospitals, healthcare providers, and patients all over the world. To date, more than 500,000 patients have been treated with TRANSCOLLATION technology.

Spinal Modulation, Inc. provides medical devices research and development services. The company is based in Menlo Park, California. According to the 2002 Health Assessment on the Prevalence of Chronic Pain, severe chronic pain, as defined by the International Association for the Study of Pain, is prevalent in 10 to 13% of the adult population. Limited treatment options exist for these patients and the burden to the healthcare system is unsustainable. The Spinal Modulation AxiumTM Neurostimulator System is a next-generation intraspinal neuromodulation therapy that stimulates the dorsal root ganglion (DRG) to provide a new pain management option. It has shown promising results in managing chronic intractable leg pain, as well as difficult-to-target anatomies such as the back and foot. By stimulating the DRG, therapy can be adjusted to cover either broad or specific areas of pain throughout the torso and legs, while limiting uncomfortable postural effects typically experienced with other spinal cord stimulators.

PhysioSonics (Seattle, WA) a development-stage device company focused on ultrasound imaging to monitor blood flow in the brain.

Osteotech is focused on the development, manufacturing, and marketing of biologic, biomaterial, and device systems for musculoskeletal surgeries. It facilitates spinal, trauma, and total joint revision procedures. Osteotech was acquired by Medtronic in November 2010. It was founded in 1986 in Eatontown, New Jersey.

Intersect ENT, Inc., a drug delivery company, researches and develops products for the treatment of patients with ear, nose, and throat conditions in the United States. The company offers PROPEL and PROPEL mini drug releasing implants for patients undergoing sinus surgery to treat chronic sinusitis; and PROPEL Contour, a steroid releasing implant to frontal and maxillary sinus ostia, or openings, of the dependent sinuses. It also provides SINUVA, a steroid releasing implant for refractory disease for the treatment of patients in the physician office setting. The company was formerly known as Sinexus, Inc. and changed its name to Intersect ENT, Inc. in November 2009. Intersect ENT, Inc. was founded in 2003 and is headquartered in Menlo Park, California.

Axon Systems is the designer and manufacturer of various NIM Eclipse nerve monitoring systems, which have been marketed and sold in the United States by the Spinal and Biologics business at Medtronic for the past three years. These devices are used in surgery to enhance patient safety by protecting delicate nerves during implant procedures. Axon Systems has introduced an impressive number of "firsts" in the field of neuromonitoring, including: 16 and 32 channel simultaneous multimodality systems, integrated transcranial MEP, microscope and vital signs views, and integrated TCD and pulse oximetery.

CardioMEMS is a medical device company that has developed and is commercializing a proprietary wireless sensing and communication technology for the human body. Their technology platform is designed to improve the management of severe chronic cardiovascular diseases such as heart failure and aneurysms. Their miniature wireless sensors can be implanted using minimally invasive techniques and transmit cardiac output, blood pressure and heart rate data that are critical to the management of patients.

ATS Medical is a medical device manufacturer specializing in cardiovascular surgery products. ATS is a global company with product sales in more than 40 countries across the globe and superior product performance in more than 80,000 mechanical heart valves implanted to date. The ATS Open Pivot® Heart Valve utilizes a unique design specifically intended to offer advantages to the surgeon and improved quality of life to the patient. Instead of cavities in the hinge area, which is the case in all other bileaflet heart valves, The ATS Open Pivot® Heart Valve has open pivots. This enables the leaflets to pivot on smooth spheres that project gently into the bloodstream. The unique configuration eliminates cavities and stagnant areas where blood may collect and clot. For more information about The ATS Open Pivot® Heart Valve, please visit the expanded discussion for patients, physicians, or investors.

Atreo Medical develops novel medical tools to aid in resuscitation. Its first product is a CPR assist device used to enhance the quality of CPR both in and out of hospital.

Fogazzi provides polymer technology.

Krauth Cardiovascular

Invatec (www.invatec.com) is an innovator in the development and commercialization of interventional coronary and peripheral products, with global headquarters in Europe. Driven by research and technology, Invatec actively collaborates with physicians and centers of excellence to develop products that will improve life expectancy and quality of life for patients. The company’s core competencies include polymer processing, metallurgy, surface treatments and drug coatings. Invatec is vertically integrated with full in-house capabilities to design, develop, manufacture and assemble its 35 product families currently offered in more than 70 countries. Dedicated to “making ideas come alive,” the company was founded in 1996 by Andrea Venturelli and Stefan Widensohler, and employs approximately 900 people, predominantly in Brescia, Italy, and Frauenfeld, Switzerland.

GI Dynamics, Inc. is a medical device company that focuses on developing non-surgical therapies for the treatment of type 2 diabetes and obesity. The company's flagship product, EndoBarrier, is designed to help patients manage these conditions effectively. Founded in 2003, GI Dynamics is headquartered in Boston, Massachusetts, and markets its products primarily in Europe, the Middle East, the Asia Pacific, and South America. The company serves healthcare providers and third-party distributors, aiming to provide innovative solutions for metabolic diseases.

Established in 1999, Salient Surgical Technologies, Inc. is a global, privately held medical technology company that develops and markets advanced energy devices used in surgical procedures. Salient’s first line of products were monopolar electrosurgical devices used for the treatment of liver cancers. Today, the company’s bipolar AQUAMANTYS® System is used across a wide range of surgical procedures including orthopaedic reconstruction, spine surgery, orthopaedic trauma, and surgical oncology. Comprised of a bipolar electrosurgical generator & pump system and a portfolio of handheld disposable device, the AQUAMANTYS system uses patented TRANSCOLLATION® technology to haemostatically seal soft tissue and bone, enabling surgeons to reduce and prevent surgical blood loss. Salient’s products are sold throughout the United States, Europe, and Asia, providing clinical and economic benefits to hospitals, healthcare providers, and patients all over the world. To date, more than 500,000 patients have been treated with TRANSCOLLATION technology.

Microchips Biotech, Inc. is dedicated to improving the lives of patients by revolutionizing drug delivery. Our proprietary microchip-based implant can store and release precise doses of drugs over months and years. The implant, which is placed under the skin by a trained physician during a simple office procedure using local anesthesia, can be wirelessly activated or deactivated by a physician or patient, without requiring removal. In addition, physicians can wirelessly modify the frequency or dose of the drug to meet the individual needs of each patient.

CardioMEMS is a medical device company that has developed and is commercializing a proprietary wireless sensing and communication technology for the human body. Their technology platform is designed to improve the management of severe chronic cardiovascular diseases such as heart failure and aneurysms. Their miniature wireless sensors can be implanted using minimally invasive techniques and transmit cardiac output, blood pressure and heart rate data that are critical to the management of patients.