Medtronic

Rosenbot provides medical robot technology and uses technological innovation to promote the reform of medical models. It is committed to creating a new generation of orthopedic surgery robot systems with intelligent fracture reduction functions, it is the first in the world to realize advanced technologies such as intraoperative real-time 3D navigation, assisted fracture reduction operation, automatic operation planning, etc. The intelligent surgical operation of the whole operation process meets the urgent needs of clinical treatment.

Fire1, based in Dublin, Ireland, is dedicated to developing innovative therapeutic devices aimed at enhancing the lives of heart failure patients. The company has created a remote monitoring system that allows healthcare providers to access real-time patient data and insights. This technology facilitates the early detection of complications associated with heart failure, enabling proactive interventions that can lead to improved patient outcomes. Through its focus on remote monitoring, Fire1 seeks to address critical challenges in heart failure management and contribute to better healthcare solutions.

Fortimedix B.V., founded in 1999 and based in Nuth, the Netherlands, specializes in the development and manufacturing of endovascular, coronary, and peripheral stents. As a global leader in stent technology, the company has established a strong presence in the medical device industry, focusing on innovation and continuous improvement. With full in-house capabilities for stent development and production, Fortimedix is dedicated to operational excellence. The company prioritizes research and development to advance its technology and meet the evolving needs of its customers and stakeholders.

Avation Medical, Inc. is focused on developing a non-invasive closed-loop neuromodulation system designed for the at-home treatment of overactive bladder. Established in 2016 and based in Columbus, Ohio, the company is pioneering wearable nerve stimulation platforms that emphasize patient empowerment and personalized care. By re-imagining neuromodulation through innovative, proven technologies, Avation Medical aims to enhance the management of chronic conditions, offering solutions that prioritize the needs and experiences of patients.

EOFlow Co., Ltd. is a South Korean company that specializes in drug delivery solutions, focusing primarily on the development and manufacturing of wearable insulin pumps. Its flagship product, EOPatch, is recognized as the world's smallest full-featured disposable insulin pump. This innovative device is designed to be smarter, better-connected, and longer-lasting than its competitors, while also being more cost-effective. EOFlow is also enhancing the EOPatch with software upgrades that will enable closed-loop insulin control, effectively functioning as an automated insulin delivery system. Additionally, the company is working on an all-in-one wearable disposable artificial pancreas solution, which has received Breakthrough Device designation from the FDA, highlighting its potential to significantly impact diabetes management.

Fire1, based in Dublin, Ireland, is dedicated to developing innovative therapeutic devices aimed at enhancing the lives of heart failure patients. The company has created a remote monitoring system that allows healthcare providers to access real-time patient data and insights. This technology facilitates the early detection of complications associated with heart failure, enabling proactive interventions that can lead to improved patient outcomes. Through its focus on remote monitoring, Fire1 seeks to address critical challenges in heart failure management and contribute to better healthcare solutions.

CathWorks Ltd. is a medical technology company that specializes in enhancing percutaneous coronary intervention (PCI) therapy decisions through its advanced computational science platform. Founded in 2013 and headquartered in Kfar-Saba, Israel, with an additional office in the United States, the company has developed the CathWorks FFRangio, a non-invasive device that provides objective, multi-vessel physiologic measurements. This tool transforms coronary angiography from a subjective visual assessment into an objective decision-making framework based on fractional flow reserve (FFR) metrics. By utilizing sophisticated algorithms to process visual information, CathWorks aims to improve the efficiency of cath lab operations and support healthcare providers in making data-driven clinical decisions.

CathWorks Ltd. is a medical technology company that specializes in enhancing percutaneous coronary intervention (PCI) therapy decisions through its advanced computational science platform. Founded in 2013 and headquartered in Kfar-Saba, Israel, with an additional office in the United States, the company has developed the CathWorks FFRangio, a non-invasive device that provides objective, multi-vessel physiologic measurements. This tool transforms coronary angiography from a subjective visual assessment into an objective decision-making framework based on fractional flow reserve (FFR) metrics. By utilizing sophisticated algorithms to process visual information, CathWorks aims to improve the efficiency of cath lab operations and support healthcare providers in making data-driven clinical decisions.

Beijing Surgerii Technology Co., Ltd. specializes in the research, development, production, and sale of minimally invasive surgical robot systems in China. Founded in 2014 and based in Beijing, the company focuses on innovative technologies, particularly the next generation of flexible continuum robotic arms. Surgerii Technology aims to transform clinical practices through its single-hole and porous laparoscopic robot systems, enhancing the standard of care in minimally invasive surgeries. With a commitment to independent research and development, the company leverages its expertise in system design and integration to advance the medical equipment industry in China.

Orchestra BioMed is a biomedical innovation company based in New Hope, Pennsylvania, founded in 2017. The company specializes in developing high-impact therapeutic solutions for major medical conditions, with a primary focus on cardiovascular diseases, which are responsible for approximately 31% of global deaths annually. Orchestra BioMed's business model involves strategic partnerships with medical device companies to accelerate the commercialization of its products. Its key product candidates include BackBeat Cardiac Neuromodulation Therapy for hypertension and Virtue Sirolimus AngioInfusionBalloon for atherosclerotic artery disease.

Titan Medical Inc. is a research and development stage company based in Toronto, Canada, specializing in the design and development of robotic surgical technologies for minimally invasive surgery (MIS). The company is advancing its flagship product, the SPORT Surgical System, which features a surgeon-controlled patient cart equipped with a 3D high-definition vision system and multi-articulating instruments. This system enables surgeons to perform a variety of surgical procedures, including gynecologic, urologic, colorectal, and abdominal surgeries, through a single port. Additionally, Titan Medical is also developing the Enos robotic single-access surgical system, further enhancing its focus on innovative solutions in the field of robotic-assisted surgery.

Affera, Inc. is a medical technology company based in Watertown, Massachusetts, established in 2013. The company focuses on developing innovative systems aimed at treating cardiac arrhythmia, a common condition that affects millions globally. By designing and advancing novel medical devices, Affera seeks to address the unmet needs within the field of cardiac arrhythmia treatment, thereby enhancing the capabilities of healthcare institutions in managing this significant health issue.

Beijing Surgerii Technology Co., Ltd. specializes in the research, development, production, and sale of minimally invasive surgical robot systems in China. Founded in 2014 and based in Beijing, the company focuses on innovative technologies, particularly the next generation of flexible continuum robotic arms. Surgerii Technology aims to transform clinical practices through its single-hole and porous laparoscopic robot systems, enhancing the standard of care in minimally invasive surgeries. With a commitment to independent research and development, the company leverages its expertise in system design and integration to advance the medical equipment industry in China.

Rockley Photonics Limited is a London-based company founded in 2013 that specializes in silicon photonics for various applications. The company develops a comprehensive range of photonic integrated circuits, sensors, and full-stack solutions aimed at high-volume markets. Rockley's technology is designed for next-generation sensing platforms, including mobile health monitoring and machine vision, as well as for high-speed data communications. By focusing on integrated optical modules, supporting electronics, software, and AI platforms, Rockley aims to establish a strong presence in dynamic and rapidly growing sectors. The company envisions photonics becoming as ubiquitous as microelectronics, leveraging its versatile platform to address diverse market needs.

Intersect ENT, Inc. is a medical device company focused on developing innovative therapies for patients with ear, nose, and throat conditions. Founded in 2003 and headquartered in Menlo Park, California, the company specializes in drug delivery products aimed at enhancing treatment outcomes for chronic sinusitis and other related ailments. Its key offerings include the PROPEL and PROPEL mini drug-releasing implants, designed for patients undergoing sinus surgery, as well as the PROPEL Contour implant, which targets frontal and maxillary sinus ostia. Additionally, Intersect ENT provides SINUVA, a steroid-releasing implant intended for use in a physician office setting to address refractory disease. The company was previously known as Sinexus, Inc. before rebranding in 2009.

Scivita Medical is a technology-focused enterprise specializing in optical diagnosis and treatment, as well as the development of multidimensional imaging and high-performance materials for minimally invasive medical procedures. The company offers a range of products, including flexible and rigid endoscopes, designed to enhance the capabilities of medical professionals. Its product lineup features advanced technologies such as ultra-high-definition visualization, 3D imaging, and fluorescence visualization, which facilitate precise diagnostics and treatments. Key offerings include a 4K medical endoscope camera system, integrated 4K-3D endoscope systems, and various single-use endoscopic devices for applications in gynecology, urology, and pulmonology. Scivita Medical aims to provide doctors with innovative tools that improve patient outcomes through enhanced visualization and minimally invasive techniques.

Marblehead Medical is a company focused on developing a medical device designed to enhance the effectiveness of mechanical thrombectomy in interventional neurovascular procedures. The device offers several key improvements, including enhanced support for distal access devices, increased suction efficiency, and a reduced risk of embolism. Additionally, it features an increased luminal diameter to accommodate contemporary distal access catheters. These advancements aim to provide stroke victims with a more effective treatment option during critical medical interventions.

BrainsGate, Ltd. is a medical device company based in Caesarea, Israel, specializing in therapies for patients with central nervous system diseases. The company has developed a technology platform that utilizes electrical stimulation of the spheno-palatine ganglion (SPG) to enhance cerebral blood flow. Currently, BrainsGate is focused on treating acute ischemic stroke through its innovative ischemic stroke system, which involves a miniature electrode implanted in the roof of the mouth during a minimally invasive procedure. This method is performed under local anesthesia and is comparable to standard dental treatments. The company has conducted several clinical trials, including a pivotal trial with 300 patients that validated the safety and efficacy of its treatment. BrainsGate is also engaged in a multi-national, randomized study known as ImpACT-24b, aimed at further assessing the effectiveness of its approach within a critical 24-hour window following a stroke.

Ai Biomed is a company based in Santa Barbara, California, specializing in the development of parathyroid detection systems. Its technology enables real-time identification of parathyroid tissue during surgical procedures, such as thyroidectomy and parathyroidectomy, as well as radical neck dissection. This innovation aims to enhance surgical precision and improve patient outcomes by providing surgeons with critical information during operations.

Triple Jump Medical is a developer of an insulin pump intended to treat diabetic patients.

BioProtect Ltd. is an international medical device startup focused on developing and commercializing biodegradable balloon spacers designed to protect normal tissue during cancer radiation therapy. The company's flagship product, the ProSpace balloon spacer, has demonstrated superior efficacy and safety in safeguarding the rectum during radiation treatment for prostate cancer. This innovative technology significantly reduces the risk of serious and chronic side effects associated with radiation, while enhancing tumor control. Founded in 2004 and headquartered in Israel, BioProtect also operates subsidiaries in Germany and the United States, aiming to address unmet clinical needs in the growing radiotherapy spacers market with its platform of biodegradable implantable balloons.

Companion Medical, Inc. is a company based in San Diego, California, that specializes in diabetes management through the development of innovative medical devices. Established in 2013, it has created InPen, a smart insulin delivery system that integrates a wireless-enabled insulin pen with a mobile application. This system calculates and recommends optimal insulin dosing, tracks the history and timing of doses, monitors insulin temperature, and reports data to healthcare providers. By utilizing advanced technologies such as Bluetooth, Companion Medical aims to enhance patient care for insulin-dependent diabetics, facilitating better management of their condition through constant tracking and monitoring of injection data. As of September 2020, Companion Medical operates as a subsidiary of Medtronic plc.

Sinovation Medical specializes in the development of advanced medical robotic technology and innovative medical products. The company is dedicated to enhancing precision in healthcare through its surgical robots, which integrate clinical computer vision technology. These robots are primarily utilized in neurosurgery, addressing conditions such as epilepsy, Parkinson's disease, cerebral hemorrhage, and intracranial tumors. By providing reliable medical robotics, Sinovation aims to improve care for patients and support medical professionals in delivering effective treatments.

Medicrea is a specialized spinal implant company committed to delivering innovative technologies for the global healthcare market. With over 18 years of experience, the company offers a comprehensive range of patented products designed to enhance patient outcomes and support healthcare professionals. Medicrea develops personalized analytical services and implant systems aimed at providing long-lasting pain relief for patients undergoing spinal surgery. Its product portfolio includes the UNiD Adaptive Spine Intelligence technology, as well as the PASS Range, Cervical Range, and TH-LUMBAR Range, each tailored to meet specific clinical needs.

Digital Surgery is a privately-held pioneer in surgical artificial intelligence (AI), data and analytics, and digital education and training.

Stimgenics is a private company that pioneered a novel spinal cord stimulation waveform known as Differential Target Multiplexed (DTM) Spinal Cord Stimulation.

Klue, Inc. is a digital health technology company based in San Mateo, California, founded in 2016. It specializes in developing artificial intelligence-based software and wearable technology that detects meals and provides insights into users' eating behaviors. By leveraging behavioral artificial intelligence, Klue aims to address obesity by helping individuals cultivate healthier eating habits in real-time. The company operates as a subsidiary of Medtronic plc.

AV Medical is a medical device company focused on developing catheter-based interventions specifically for dialysis patients who require routine angioplasty procedures. Its primary product, the Chameleon PTA balloon catheter, incorporates innovative Supervision technology that allows for the targeted injection of diagnostic fluids. This feature enables physicians to visualize the status of the balloon—whether inflated or deflated—while maintaining wire position, thereby enhancing procedural efficiency and safety. The Chameleon catheter has undergone clinical testing in various dialysis access procedures, demonstrating its potential to improve outcomes for both patients and healthcare providers.

Saluda Medical is a commercial-stage medical device company focused on developing innovative treatments for chronic neurological conditions, particularly chronic neuropathic pain. The company utilizes a unique closed-loop neuromodulation platform that senses and measures neural responses to stimulation. This technology automatically adjusts the therapy based on real-time neurophysiological feedback, allowing for personalized treatment tailored to each patient's specific needs. By monitoring the patient's neural fingerprint, Saluda Medical’s devices enable the precise delivery of electrical stimulation, ultimately improving the management of chronic back pain and enhancing patient outcomes.

Titan Spine, Inc. specializes in the design and manufacture of interbody fusion devices for cervical and lumbar spine applications. Its product line includes the Endoskeleton TL for lateral lumbar fusion, Endoskeleton TAS and TA for anterior lumbar interbody fusion, Endoskeleton TT for transforaminal lumbar interbody fusion, Endoskeleton TO for posterior lumbar interbody fusion, and Endoskeleton TCS and TC for anterior discectomy and fusion. The company aims to enhance patient recovery and surgical outcomes through its innovative textured implants, which facilitate better integration with the body. Titan Spine serves patients in the United States and Europe via a dedicated sales force and a network of independent distributors. Founded in 2005 and headquartered in Mequon, Wisconsin, with an additional location in Laichingen, Germany, Titan Spine operates as a subsidiary of Medtronic plc.

EPIX Therapeutics, Inc. is a medical device company based in Santa Clara, California, specializing in the development of advanced temperature-sensing irrigated radiofrequency ablation catheters for the treatment of atrial fibrillation and other cardiac arrhythmias. Utilizing its proprietary TempaSure technology, which incorporates microwave radiometry, EPIX Therapeutics provides precise real-time feedback on volumetric temperature during ablation procedures. This technology enables physicians to control and predict lesion formation more accurately, ultimately enhancing clinical outcomes for patients. Founded in 2007 and previously known as Advanced Cardiac Therapeutics, EPIX Therapeutics has formed strategic partnerships with industry leaders such as Abbott Laboratories and Hansen Medical Inc. The company operates as a subsidiary of Medtronic plc, focusing on improving the treatment of irregular heart rhythms through its innovative catheter-based systems.

Nutrino Health Ltd. is a nutrition insights software company based in Tel Aviv, Israel, founded in 2011. It specializes in developing a digital platform that provides personalized meal recommendations and nutrition-related analytics. The company's primary offering, FoodPrint, utilizes individual biochemistry to assess how food impacts health, creating a unique digital signature for each user. By integrating data from wearables and employing image recognition technology, Nutrino delivers tailored nutritional advice based on users' profiles, goals, and preferences. The platform serves a diverse clientele, including individuals, businesses, and health professionals, enabling users to maintain their health and achieve their dietary objectives. Nutrino operates as a subsidiary of Medtronic plc.

Mazor Robotics, founded in 2001 and headquartered in Caesarea, Israel, specializes in developing, producing, and marketing medical devices for orthopedic and neurosurgical procedures. The company's primary focus is on surgical robotic-guidance systems that enhance precision and minimize invasiveness during complex surgeries. Their flagship products include the Mazor X and Renaissance systems, which are used extensively in spine surgeries such as fusion, correction of spinal deformities, biopsy collection, tumor excision, and cement augmentations. These systems aim to provide a safer surgical environment for patients, surgeons, and operating room staff by transforming traditional freehand procedures into highly accurate, state-of-the-art operations with better clinical outcomes.

MC10, Inc. specializes in the development and sale of wearable medical sensors designed to collect clinical-grade biometric and physiological data, primarily for use in clinical trials. Founded in 2008 and based in Lexington, Massachusetts, the company offers a range of products, including BioStamp nPoint, which processes raw data into clinical metrics such as vital signs and sleep patterns; Kintinuum, an orthopedic rehabilitation device; WiSP, a cardiac monitoring solution; and BioStampMD, a conformable sensor for gathering both objective and subjective health data. MC10 focuses on creating flexible, lightweight electronics that conform to the human body, allowing for discreet and comfortable data collection in various settings. Its proprietary BioStamp system enhances the ability to gather real-world data on muscle activation and movement, thereby advancing digital healthcare services across multiple sectors, including sports and military applications.

Nanos Medical specializes in the research, development, manufacturing, and sales of disposable medical devices, primarily targeting the cardiovascular and ear, nose, and throat (ENT) fields. The company offers a range of innovative products, including sinus balloon catheters, eustachian tube balloons, disposable nasopharyngeal airways, nasolacrimal balloons, and drug-eluting stents for sinus applications. Through its advanced medical devices, Nanos Medical aims to enhance treatment options for hospitals and patients, contributing to improved healthcare outcomes.

Yosemite Clinic is a multidisciplinary medical center located in Central Pudong, Shanghai, offering a wide range of walk-in services in a modern and well-equipped environment. The clinic provides specialties including family medicine, internal medicine, gynecology, pediatrics, rehabilitation, sports medicine, dentistry, ophthalmology, dermatology, and medical cosmetology. It is particularly noted for its focus on Minimally Invasive Surgery and Ambulatory Surgery. The facility is equipped with advanced medical imaging technology, including CT, X-ray, and ultrasound, alongside a fully operational laboratory and pharmacy. The clinic's diverse team of healthcare professionals hails from both China and around the world, allowing them to offer services in multiple languages such as English, Japanese, Malay, Mandarin Chinese, and Cantonese, ensuring comprehensive care for a diverse patient population.

VisionSense develops innovative visualization solutions designed to enhance minimally invasive surgery (MIS). By utilizing advanced sensor technology and proprietary software, the VisionSense system provides surgeons with stereoscopic sight, delivering depth perception and high-definition 3D images through the smallest access points. Unlike traditional MIS vision solutions that offer only 2D images, VisionSense's technology significantly improves a surgeon's perspective by enabling better tissue understanding and hand-eye coordination. This enhancement allows for the confident use of advanced articulating surgical tools, ultimately facilitating more complex surgical procedures.

Fire1, based in Dublin, Ireland, is dedicated to developing innovative therapeutic devices aimed at enhancing the lives of heart failure patients. The company has created a remote monitoring system that allows healthcare providers to access real-time patient data and insights. This technology facilitates the early detection of complications associated with heart failure, enabling proactive interventions that can lead to improved patient outcomes. Through its focus on remote monitoring, Fire1 seeks to address critical challenges in heart failure management and contribute to better healthcare solutions.

AEGEA Medical, Inc. is a medical technology company based in Menlo Park, California, focused on improving women's healthcare through innovative treatment options. The company has developed a water vapor ablation system, known as Mara, which provides a safe and effective method for endometrial ablation to treat heavy menstrual bleeding, or menorrhagia. This FDA-approved technology allows for a straightforward, office-based procedure that typically takes only minutes to perform. AEGEA is dedicated to enhancing patient outcomes and expanding access to effective therapies, while also supporting physicians in delivering these procedures with confidence and ease. Founded in 2008, AEGEA Medical is committed to pioneering advancements in women’s health.

Crospon Limited specializes in the development of minimally invasive medical devices designed for imaging and assisting surgeries in the esophagus and stomach. The company offers the EndoFLIP imaging system, which measures the dimensions and functionality of various hollow organs and sphincteric regions. Its product line includes measurement and dilation catheters, as well as endoscopic and laparoscopic accessories, catering to applications in upper gastrodiagnostics, bariatric surgery, upper GI imaging, cardiology, therapeutic endoscopy, and colorectal imaging. Crospon's products are distributed in multiple regions, including the United States, Europe, and various countries in Africa, Asia, and Latin America. Founded in 2006 and based in Galway, Ireland, Crospon operates as a subsidiary of Medtronic plc.

Semma Therapeutics, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative cell therapies for patients with Type 1 diabetes. Founded in 2014, the company is dedicated to creating a transformative treatment that addresses the need for insulin injections by generating functional, insulin-producing beta cells through a proprietary method licensed from the laboratory of Professor Douglas Melton. Semma Therapeutics aims to combine these engineered cells with advanced devices to offer a potential replacement for the missing beta cells in diabetic patients, eliminating the need for immunosuppression. The company's ongoing research seeks to bring this novel therapeutic option to clinical settings, ultimately improving the lives of individuals living with diabetes.

Mazor Robotics, founded in 2001 and headquartered in Caesarea, Israel, specializes in developing, producing, and marketing medical devices for orthopedic and neurosurgical procedures. The company's primary focus is on surgical robotic-guidance systems that enhance precision and minimize invasiveness during complex surgeries. Their flagship products include the Mazor X and Renaissance systems, which are used extensively in spine surgeries such as fusion, correction of spinal deformities, biopsy collection, tumor excision, and cement augmentations. These systems aim to provide a safer surgical environment for patients, surgeons, and operating room staff by transforming traditional freehand procedures into highly accurate, state-of-the-art operations with better clinical outcomes.

SetPoint Medical is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices aimed at treating chronic autoimmune diseases. The company is creating a platform that stimulates the vagus nerve to activate the body's natural inflammatory reflex, leading to a systemic immune-restorative effect. This innovative approach offers an alternative treatment option for conditions such as rheumatoid arthritis and inflammatory bowel disease, with the potential for reduced risks and costs compared to traditional drug therapies. SetPoint Medical, originally known as Innovative Metabolics Inc. until its name change in 2008, aims to provide patients and healthcare providers with effective solutions for managing debilitating inflammatory diseases.

Glooko is a company that develops a remote patient-monitoring platform specifically designed for individuals with diabetes. This platform integrates with various diabetes devices, fitness wearables, and activity trackers to capture and sync health data. It provides comprehensive reports and analytics aimed at promoting behavior change and improving health outcomes. By enhancing communication between patients and healthcare providers, Glooko facilitates better management of diabetes and supports remote monitoring efforts. The platform is accessible on both Android and iOS devices, allowing users to conveniently track their diabetes-related information on their smartphones.

Earlens is a medical technology company focused on improving the hearing experience for individuals with hearing loss. It has created the Earlens Contact Hearing Solution, a unique device that directly stimulates the eardrum using a small lens, replicating the natural hearing process. Unlike conventional hearing aids that amplify sound, the Earlens solution delivers sound directly to the eardrum, providing superior sound quality and a broader bandwidth. This innovative, non-surgical approach allows for automatic adjustments in challenging listening environments while minimizing feedback. The technology received FDA clearance in 2019 for its second generation, marking a significant advancement in hearing solutions aimed at enhancing the quality of life for those with hearing impairment.

Saluda Medical is a commercial-stage medical device company focused on developing innovative treatments for chronic neurological conditions, particularly chronic neuropathic pain. The company utilizes a unique closed-loop neuromodulation platform that senses and measures neural responses to stimulation. This technology automatically adjusts the therapy based on real-time neurophysiological feedback, allowing for personalized treatment tailored to each patient's specific needs. By monitoring the patient's neural fingerprint, Saluda Medical’s devices enable the precise delivery of electrical stimulation, ultimately improving the management of chronic back pain and enhancing patient outcomes.

Semma Therapeutics, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative cell therapies for patients with Type 1 diabetes. Founded in 2014, the company is dedicated to creating a transformative treatment that addresses the need for insulin injections by generating functional, insulin-producing beta cells through a proprietary method licensed from the laboratory of Professor Douglas Melton. Semma Therapeutics aims to combine these engineered cells with advanced devices to offer a potential replacement for the missing beta cells in diabetic patients, eliminating the need for immunosuppression. The company's ongoing research seeks to bring this novel therapeutic option to clinical settings, ultimately improving the lives of individuals living with diabetes.

Forerunner Medical (Shanghai) Co., Ltd., established in 2009, specializes in the development and manufacturing of medical devices tailored for minimally invasive procedures. The company focuses on low-temperature plasma radio-frequency generators and electrodes, catering to sports medicine and tumor treatment. By leveraging domestic clinical data and technology from the United States, Forerunner Medical aims to meet both local and global healthcare needs. Their commitment to quality and safety is evident in their products, which are designed to offer enhanced performance, aesthetic appeal, and user convenience. With a strong emphasis on innovation and professional expertise, Forerunner Medical strives to provide superior medical technologies that improve surgical outcomes for doctors and patients alike.

Inspire Medical Systems, Inc. is a medical technology company dedicated to developing and commercializing minimally invasive solutions for patients suffering from obstructive sleep apnea (OSA). Founded in 2007 and headquartered in Golden Valley, Minnesota, the company specializes in innovative implantable neurostimulation technologies. Its primary product, the Inspire system, utilizes a proprietary Upper Airway Stimulation (UAS) therapy that provides a safe and effective treatment for moderate to severe OSA. This technology leverages established principles from cardiac pacing and neurostimulation to deliver mild hypoglossal nerve stimulation, which helps maintain an open airway by continuously monitoring the patient's breathing. Inspire Medical Systems operates primarily in the United States and Europe, generating most of its revenue from the U.S. market.

MD Start SA is a medical technology incubator based in Lausanne, Switzerland, that specializes in transforming innovative ideas into viable medical solutions. Founded in 2009, the company creates, develops, and operates medical projects, effectively turning them into new companies. MD Start employs both strategic and hands-on approaches to guide these projects through the investment stage and into commercial development. The firm collaborates with notable partners in the medical device sector, including Medtronic, Sofinnova Partners, and Versant Ventures, among others. Through its focused efforts, MD Start aims to support the growth of medical device start-ups and facilitate the advancement of healthcare technologies.

Mazor Robotics, founded in 2001 and headquartered in Caesarea, Israel, specializes in developing, producing, and marketing medical devices for orthopedic and neurosurgical procedures. The company's primary focus is on surgical robotic-guidance systems that enhance precision and minimize invasiveness during complex surgeries. Their flagship products include the Mazor X and Renaissance systems, which are used extensively in spine surgeries such as fusion, correction of spinal deformities, biopsy collection, tumor excision, and cement augmentations. These systems aim to provide a safer surgical environment for patients, surgeons, and operating room staff by transforming traditional freehand procedures into highly accurate, state-of-the-art operations with better clinical outcomes.

HeartWare International, Inc. specializes in the development and manufacturing of small implantable heart pumps, also known as ventricular assist devices, aimed at treating advanced heart failure. The company offers the HeartWare Ventricular Assist System, which comprises a left ventricular assist device, patient accessories, and surgical tools designed to provide critical circulatory support for patients in the advanced stages of heart failure. Additionally, HeartWare is working on the Miniaturized Ventricular Assist Device, intended for chronic heart failure patients. The company markets its products through clinical studies in the United States and directly to cardiac centers and hospitals worldwide. Headquartered in Framingham, Massachusetts, HeartWare is committed to improving the quality of life for patients suffering from severe heart conditions.

Earlens is a medical technology company focused on improving the hearing experience for individuals with hearing loss. It has created the Earlens Contact Hearing Solution, a unique device that directly stimulates the eardrum using a small lens, replicating the natural hearing process. Unlike conventional hearing aids that amplify sound, the Earlens solution delivers sound directly to the eardrum, providing superior sound quality and a broader bandwidth. This innovative, non-surgical approach allows for automatic adjustments in challenging listening environments while minimizing feedback. The technology received FDA clearance in 2019 for its second generation, marking a significant advancement in hearing solutions aimed at enhancing the quality of life for those with hearing impairment.

Responsive Orthopedics LLC is a Minneapolis-based company that designs and develops knee implant systems, with a focus on providing low-cost hip and knee replacements. Established in 2013, the company offers logistical support to physician practices and hospitals, catering specifically to healthcare providers involved in federal programs aimed at reducing the costs associated with hip and knee procedures. In June 2016, Responsive Orthopedics became a subsidiary of Medtronic plc, further bolstering its capabilities in the healthcare marketplace. The company’s commitment to affordability and support positions it as a significant player in the orthopedic implant sector.

Gynaecology has been rapidly built around Smith & Nephew's resection technologies and comprises, primarily, the TRUCLEAR◊ System for the hysteroscopic resection and removal of uterine tissue. Gynaecology delivered revenue of $56 million in 2015, representing a little over 1% of Group revenue.

Bellco is an Italian company recognized as a pioneer in the field of haemodialysis, dedicated to addressing the needs of patients and healthcare professionals through innovation and research. The company specializes in the manufacturing and distribution of medical devices for renal care, including dialyzers, fluids, machines, and hematic lines designed for the treatment of kidney diseases. In addition to its focus on haemodialysis, Bellco develops equipment for extra-corporeal blood filtration, supporting advanced therapies in Nephrology, Intensive Care, and Cardiology. Through its commitment to technological advancement, Bellco continues to play a significant role in improving patient care in the realm of renal health.

Aircraft Medical Limited is a developer and producer of handheld medical devices specializing in anesthesia and critical care. Founded in 2001 and based in Edinburgh, United Kingdom, the company is known for its flagship product, the McGRATH, a portable video laryngoscope designed to enhance the intubation process. Aircraft Medical's innovations aim to provide life-saving technology for anesthesia professionals, focusing on reducing patient trauma, minimizing cross-contamination, and improving communication and efficiency in clinical training. The company distributes its products through partners across various regions, including the United States, Canada, the United Kingdom, and several countries in Europe and Australasia. Aircraft Medical was formerly known as Smartscope MD Ltd. and adopted its current name in February 2004. As of November 2015, it operates as a subsidiary of Medtronic plc.

Lazarus Effect is a medical device company specializing in the development of innovative interventional devices designed for the removal of blood clots. The company has created a comprehensive portfolio of vascular-device products built on a patented wire-frame technology platform. Currently, Lazarus Effect holds five issued US patents along with numerous pending patent applications globally. Its notable products include the Lazarus Funnel™ Guide Catheter and Lazarus ReCover devices, which have received CE Mark approval for use in Europe, while the Funnel has also been cleared for use in the United States. The Lazarus Cover device is awaiting CE Mark approval. However, the ReCover and Cover devices are not yet approved for sale in the United States.

SetPoint Medical is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices aimed at treating chronic autoimmune diseases. The company is creating a platform that stimulates the vagus nerve to activate the body's natural inflammatory reflex, leading to a systemic immune-restorative effect. This innovative approach offers an alternative treatment option for conditions such as rheumatoid arthritis and inflammatory bowel disease, with the potential for reduced risks and costs compared to traditional drug therapies. SetPoint Medical, originally known as Innovative Metabolics Inc. until its name change in 2008, aims to provide patients and healthcare providers with effective solutions for managing debilitating inflammatory diseases.

Medina is a medical laboratory that provides analysis and diagnostics services.

Twelve manufactures medical devices. It was formerly known as Foundry Newco XII, Inc. The company was incorporated in 2009 and is based in Menlo Park, California.

RF Surgical Systems, Inc. specializes in detection technology aimed at preventing retained surgical sponges in hospitals and trauma centers across the United States. The company offers the RF Assure Detection System X, which is widely used in operating rooms, trauma, and labor and delivery suites, along with an array of handheld and motion-based scanning devices. Its products cater to various surgical applications, including procedures involving extremities, head, neck, spine, and other specialties. Founded in 2004 and headquartered in Carlsbad, California, RF Surgical Systems has established itself as a market leader in this field, with its technology employed in over 1,500 facilities nationwide. The company’s innovations are protected by U.S. patents, and it received regulatory clearance from the U.S. Food and Drug Administration in November 2006. As of August 2015, RF Surgical Systems operates as a subsidiary of Medtronic plc.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, that specializes in a non-invasive cardiac mapping system designed to visualize electrical disorders of the heart. The company's flagship product, ECVUE, utilizes an electrocardiographic mapping platform that combines body surface electrical data with anatomical information from CT scans to create simultaneous, multi-chamber, three-dimensional (3D) maps of cardiac electrical activity. The system employs a single-use, disposable multi-sensor vest to capture electrical signals from the body surface, which are then processed by software to produce detailed epicardial 3D electroanatomic maps and virtual electrograms. This innovative approach aids physicians in accurately diagnosing and treating heart conditions such as arrhythmias and congestive heart failure, a capability supported by over 260 patient studies. CardioInsight Technologies operates as a subsidiary of Medtronic plc, having been founded in 2006.

Aptus Endosystems, Inc. is a medical device company focused on developing innovative solutions for endovascular aneurysm repair (EVAR). Founded in 2002 and based in Sunnyvale, California, the company specializes in advanced technologies for treating aortic aneurysm disease. Its flagship products include the Heli-FX EndoAnchor system, designed for abdominal and thoracic aortic aneurysms, and the Aptus TourGuide steerable sheath, which facilitates the delivery of peripheral vascular products. The proprietary helical staple technology used in the endograft system allows for independent fixation, mimicking suturing in open surgical procedures while maintaining a minimally invasive approach. Aptus Endosystems serves a range of markets, including the United States and several European countries, distributing its products through various distributors. The company's products hold CE Marking for distribution in the European Union, although they are currently designated for investigational use only in the United States.

AEGEA Medical, Inc. is a medical technology company based in Menlo Park, California, focused on improving women's healthcare through innovative treatment options. The company has developed a water vapor ablation system, known as Mara, which provides a safe and effective method for endometrial ablation to treat heavy menstrual bleeding, or menorrhagia. This FDA-approved technology allows for a straightforward, office-based procedure that typically takes only minutes to perform. AEGEA is dedicated to enhancing patient outcomes and expanding access to effective therapies, while also supporting physicians in delivering these procedures with confidence and ease. Founded in 2008, AEGEA Medical is committed to pioneering advancements in women’s health.

Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Established in 2006, it develops advanced diagnostic technology solutions for assessing spinal instability. The company offers the KineGraph Vertebral Motion Analyzer, an automated system that utilizes fluoroscopy to capture spine motion, generating patient-specific graphs that aid clinicians in diagnosing and treating back and neck pain. Additionally, Ortho Kinematics provides cloud-based analysis of instability testing results along with video X-ray imaging services through its imaging center. The company's innovations support spine clinicians by delivering critical insights into spinal health.

DreaMed Diabetes, Ltd. is a medical device and software-as-a-service company focused on diabetes treatment and management. Founded in 2014 and based in Israel, the company is known for its innovative solutions, including Glucositter, a closed-loop insulin delivery system that monitors glucose levels in real-time and adjusts insulin delivery accordingly. DreaMed Diabetes has made significant advancements in decision support tools for diabetes management and was the first company to receive FDA clearance for a decision support system that utilizes data from continuous glucose monitors and insulin pumps. Its Advisor Pro software, developed by diabetes professionals, leverages artificial intelligence to enable healthcare providers to quickly analyze patient data and determine optimal treatment plans. This system aims to improve patient outcomes by facilitating frequent titration changes and enhancing online monitoring, ultimately helping to lower A1C levels and reduce the risk of complications. DreaMed Diabetes emphasizes patient-centered care, ensuring that all individuals receive high-quality treatment regardless of their circumstances.

Diabeter is an independent diabetes clinic and research center located in the Netherlands, focused on delivering comprehensive diabetes care services. The organization aims to create a future without diabetes complications through various offerings, including diabetes diagnosis, insulin pen treatment, and insulin pump therapy. Additionally, Diabeter provides E-health services, educational resources, and daily telephone consultations with medical specialists who specialize in diabetes care. This holistic approach allows the clinic to offer individualized support to patients, helping them manage their condition effectively and improve their quality of life while minimizing complications associated with diabetes.

Sophono, Inc. is a medical device manufacturer based in Boulder, Colorado, specializing in implantable magnetic bone conduction hearing devices. Founded in 2009, the company focuses on providing solutions for individuals with conductive hearing loss, mixed hearing loss, and single-sided deafness. Its flagship product, the Alpha 2 MPO, offers an abutment-free design that allows for under-the-skin implantation, enhancing user comfort and convenience. Sophono's devices are designed for patients experiencing severe to profound hearing impairment, and they are distributed through clinics. As of 2015, Sophono operates as a subsidiary of Medtronic plc.

Semma Therapeutics, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative cell therapies for patients with Type 1 diabetes. Founded in 2014, the company is dedicated to creating a transformative treatment that addresses the need for insulin injections by generating functional, insulin-producing beta cells through a proprietary method licensed from the laboratory of Professor Douglas Melton. Semma Therapeutics aims to combine these engineered cells with advanced devices to offer a potential replacement for the missing beta cells in diabetic patients, eliminating the need for immunosuppression. The company's ongoing research seeks to bring this novel therapeutic option to clinical settings, ultimately improving the lives of individuals living with diabetes.

Glooko is a company that develops a remote patient-monitoring platform specifically designed for individuals with diabetes. This platform integrates with various diabetes devices, fitness wearables, and activity trackers to capture and sync health data. It provides comprehensive reports and analytics aimed at promoting behavior change and improving health outcomes. By enhancing communication between patients and healthcare providers, Glooko facilitates better management of diabetes and supports remote monitoring efforts. The platform is accessible on both Android and iOS devices, allowing users to conveniently track their diabetes-related information on their smartphones.

Advanced Uro-Solutions is a company that specializes in the development and manufacturing of medical devices aimed at treating various health conditions. One of its primary products is the NURO percutaneous tibial nerve stimulation system, which includes a small external stimulator and a reusable lead designed to provide temporary stimulation to the tibial nerve. This technology is particularly focused on addressing urinary urgency and incontinence, as well as bowel control disorders. Additionally, the company explores solutions for cardiac rhythm disorders and neurological conditions, contributing to a broader spectrum of healthcare needs.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to restore near vision for presbyopic patients while preserving distance vision. Additionally, AcuFocus develops the IC-8 IOL, a small aperture lens that facilitates a range of vision for patients with cataracts. The AcuTarget HD is another key product, serving as a diagnostic and surgical planning instrument for various vision correction procedures, including LASIK and cataract surgeries. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, addressing the needs of both physicians and patients in the vision care sector. Founded in 2001, AcuFocus continues to focus on innovative solutions for vision-related challenges.

Founded by Dr. Eugenio Cremascoli, the main business of NGC Medical Focuses are: Project planning, manufacturing and marketing of medical and surgical devices Import and distribution in national territory of medical devices, medical data management systems, medical communications database for remote access and medical equipment Design and turnkey implementation of Surgery Units, Intensive Care, Hemodynamics, Electrophysiology and Intervention Radiology Laboratories In-service management of Surgical Suites, Intensive Care, Hemodynamics, Electrophysiology and Intervention Radiology Laboratories Design and implementation of Information Management Software packages unifying the administrative and clinical departments within at single interface

Sapiens Steering Brain Stimulation GmbH is a medical device company focused on advancing deep brain stimulation (DBS) therapy. Founded in 2011 as a spin-out of Royal Philips Electronics, the company aims to enhance patient comfort and therapeutic outcomes with its innovative, high-resolution, and MRI-compatible DBS system. Sapiens specializes in developing a comprehensive DBS solution that includes navigation and steering software, as well as implants specifically designed for patients with Parkinson's disease. With offices in Eindhoven, the Netherlands, and Munich, Germany, Sapiens leverages patented technologies to deliver effective and precise treatment options for individuals suffering from this neurological condition.

Visualase, Inc., founded in 2005 as a spin-off from BioTex, Inc., is a privately held company based in Houston, Texas. It specializes in developing laser and image-guided technologies specifically for thermal ablation applications. The company has created innovative tools designed for the treatment of cancer and other malignancies, utilizing advanced laser and MRI-based guidance systems to enhance precision and effectiveness in medical procedures.

Covidien plc is a healthcare company involved in the development, manufacture, and sale of a wide range of products intended for clinical and home use, aimed at improving patient outcomes while reducing healthcare costs. The company operates through four primary segments: Medical Devices, Imaging Solutions, Pharmaceutical Products, and Medical Supplies. Within the Medical Devices segment, Covidien produces endomechanical instruments, soft tissue repair products, energy devices, oximetry and monitoring products, airway and ventilation products, vascular devices, and SharpSafety products. The Imaging Solutions segment focuses on radiopharmaceuticals and contrast products, while the Pharmaceutical Products segment encompasses dosage pharmaceuticals and active pharmaceutical ingredients. Finally, the Medical Supplies segment includes nursing care products and medical surgical products. Covidien collaborates with medical professionals to enhance the quality of life for patients through its innovative healthcare solutions.

Corventis is a company focused on improving clinical outcomes and reducing healthcare costs through innovative medical technologies aimed at cardiovascular diseases. Its primary offering is a non-invasive monitor that measures various aspects of heart function, facilitating the early detection of cardiovascular events. This approach not only enhances patient care but also allows individuals to maintain an active lifestyle while managing their heart health.

Inspire Medical Systems, Inc. is a medical technology company dedicated to developing and commercializing minimally invasive solutions for patients suffering from obstructive sleep apnea (OSA). Founded in 2007 and headquartered in Golden Valley, Minnesota, the company specializes in innovative implantable neurostimulation technologies. Its primary product, the Inspire system, utilizes a proprietary Upper Airway Stimulation (UAS) therapy that provides a safe and effective treatment for moderate to severe OSA. This technology leverages established principles from cardiac pacing and neurostimulation to deliver mild hypoglossal nerve stimulation, which helps maintain an open airway by continuously monitoring the patient's breathing. Inspire Medical Systems operates primarily in the United States and Europe, generating most of its revenue from the U.S. market.

PowerVision, Inc. is a company that specializes in the development of innovative intraocular lenses aimed at restoring vision for individuals suffering from presbyopia and cataracts. Founded in 2002 and based in Belmont, California, PowerVision has created the FluidVision accommodating intraocular lens, which utilizes a unique fluid-controlled mechanism to mimic the natural function of a healthy eye. This technology allows users to dynamically adjust their focus for clear vision at all distances, potentially liberating millions from the need for glasses or other vision correction methods. The FluidVision lens is designed to meet the clinical and lifestyle needs of patients, offering a significant advancement in vision correction surgery. PowerVision's approach addresses the visual impairments faced by over 20 million people in the United States with cataracts and more than 90 million individuals affected by presbyopia, particularly those in their 40s and 50s.

TyRx specializes in the design, development, and commercialization of resorbable polymeric biomaterials, focusing on drug-device combination products. The company offers PIVIT CRM, a mesh-based pouch designed to protect against microbial colonization of surgical implants such as generators and defibrillators during and immediately after surgery. Additionally, TyRx provides AIGISRx Flat, an antibacterial solution aimed at preventing infections linked to implanted pacemakers and defibrillators. Founded in 1997 and headquartered in Monmouth Junction, New Jersey, TyRx is committed to advancing medical technology through innovative products that enhance patient safety.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, that specializes in a non-invasive cardiac mapping system designed to visualize electrical disorders of the heart. The company's flagship product, ECVUE, utilizes an electrocardiographic mapping platform that combines body surface electrical data with anatomical information from CT scans to create simultaneous, multi-chamber, three-dimensional (3D) maps of cardiac electrical activity. The system employs a single-use, disposable multi-sensor vest to capture electrical signals from the body surface, which are then processed by software to produce detailed epicardial 3D electroanatomic maps and virtual electrograms. This innovative approach aids physicians in accurately diagnosing and treating heart conditions such as arrhythmias and congestive heart failure, a capability supported by over 260 patient studies. CardioInsight Technologies operates as a subsidiary of Medtronic plc, having been founded in 2006.

Cardiocom specializes in telemedicine solutions focused on daily remote patient monitoring and disease management. The company provides health professionals with telehealth devices and services designed to identify symptomatic patients and facilitate early interventions, thereby reducing unnecessary hospitalizations. Cardiocom's offerings address a range of chronic conditions, including congestive heart failure, chronic obstructive pulmonary disease, asthma, diabetes, hypertension, and obesity. The product lineup includes the Cardiocom OMNIVISOR PRO Patient Management System, TELESCALE for heart failure management, and COMMANDER for patients with multiple chronic diseases. By implementing Cardiocom's proactive solutions, healthcare organizations can enhance patient quality of life while achieving cost savings in health management.

Intersect ENT, Inc. is a medical device company focused on developing innovative therapies for patients with ear, nose, and throat conditions. Founded in 2003 and headquartered in Menlo Park, California, the company specializes in drug delivery products aimed at enhancing treatment outcomes for chronic sinusitis and other related ailments. Its key offerings include the PROPEL and PROPEL mini drug-releasing implants, designed for patients undergoing sinus surgery, as well as the PROPEL Contour implant, which targets frontal and maxillary sinus ostia. Additionally, Intersect ENT provides SINUVA, a steroid-releasing implant intended for use in a physician office setting to address refractory disease. The company was previously known as Sinexus, Inc. before rebranding in 2009.

MC10, Inc. specializes in the development and sale of wearable medical sensors designed to collect clinical-grade biometric and physiological data, primarily for use in clinical trials. Founded in 2008 and based in Lexington, Massachusetts, the company offers a range of products, including BioStamp nPoint, which processes raw data into clinical metrics such as vital signs and sleep patterns; Kintinuum, an orthopedic rehabilitation device; WiSP, a cardiac monitoring solution; and BioStampMD, a conformable sensor for gathering both objective and subjective health data. MC10 focuses on creating flexible, lightweight electronics that conform to the human body, allowing for discreet and comfortable data collection in various settings. Its proprietary BioStamp system enhances the ability to gather real-world data on muscle activation and movement, thereby advancing digital healthcare services across multiple sectors, including sports and military applications.

Kanghui was founded in 1997 and is headquartered in Changzhou. Kanghui announced today that it requested that trading of its American depositary shares on the NYSE be suspended. Kanghui has requested that the NYSE file Form 25 with the U.S. Securities and Exchange Commission (the “SEC”) notifying the SEC of the delisting of Kanghui’s American depositary shares from NYSE and the deregistration of the Company’s registered securities. Kanghui intends to terminate its reporting obligations under the Securities Exchange Act of 1934, as amended by promptly filing Form 15 with the SEC.

Mitralign is a privately held company based in a suburb of Boston, Massachusetts, focused on developing a catheter-based technology for the treatment of functional mitral regurgitation. The company has created an innovative system that mimics surgical annuloplasty by delivering surgical implants directly into the mitral annulus via a catheter. This process involves cinching the implants together to decrease the size of the mitral valve annulus and the valve opening. Mitralign's technology aims to provide a less invasive option for managing this life-threatening cardiac condition, enabling healthcare providers to effectively treat symptomatic functional mitral regurgitation through tissue-plication. The company is supported by prominent venture capitalists and has attracted investments from major cardiovascular device firms.

Inspire Medical Systems, Inc. is a medical technology company dedicated to developing and commercializing minimally invasive solutions for patients suffering from obstructive sleep apnea (OSA). Founded in 2007 and headquartered in Golden Valley, Minnesota, the company specializes in innovative implantable neurostimulation technologies. Its primary product, the Inspire system, utilizes a proprietary Upper Airway Stimulation (UAS) therapy that provides a safe and effective treatment for moderate to severe OSA. This technology leverages established principles from cardiac pacing and neurostimulation to deliver mild hypoglossal nerve stimulation, which helps maintain an open airway by continuously monitoring the patient's breathing. Inspire Medical Systems operates primarily in the United States and Europe, generating most of its revenue from the U.S. market.

Visualase, Inc., founded in 2005 as a spin-off from BioTex, Inc., is a privately held company based in Houston, Texas. It specializes in developing laser and image-guided technologies specifically for thermal ablation applications. The company has created innovative tools designed for the treatment of cancer and other malignancies, utilizing advanced laser and MRI-based guidance systems to enhance precision and effectiveness in medical procedures.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, that specializes in a non-invasive cardiac mapping system designed to visualize electrical disorders of the heart. The company's flagship product, ECVUE, utilizes an electrocardiographic mapping platform that combines body surface electrical data with anatomical information from CT scans to create simultaneous, multi-chamber, three-dimensional (3D) maps of cardiac electrical activity. The system employs a single-use, disposable multi-sensor vest to capture electrical signals from the body surface, which are then processed by software to produce detailed epicardial 3D electroanatomic maps and virtual electrograms. This innovative approach aids physicians in accurately diagnosing and treating heart conditions such as arrhythmias and congestive heart failure, a capability supported by over 260 patient studies. CardioInsight Technologies operates as a subsidiary of Medtronic plc, having been founded in 2006.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to restore near vision for presbyopic patients while preserving distance vision. Additionally, AcuFocus develops the IC-8 IOL, a small aperture lens that facilitates a range of vision for patients with cataracts. The AcuTarget HD is another key product, serving as a diagnostic and surgical planning instrument for various vision correction procedures, including LASIK and cataract surgeries. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, addressing the needs of both physicians and patients in the vision care sector. Founded in 2001, AcuFocus continues to focus on innovative solutions for vision-related challenges.

Functional Neuromodulation is a medical technology company focused on developing neuromodulation therapies for cognitive and memory disorders, particularly Alzheimer's disease and mild cognitive impairment. Founded in 2010, the company is headquartered in Minneapolis, Minnesota, with an additional office in Toronto, Canada. It offers a deep brain stimulation (DBS) technology that involves a surgically implanted medical device designed to deliver mild electrical pulses to specific areas of the brain. This approach aims to enhance neural activity and modulate the brain's memory circuits, ultimately enabling patients with cognitive impairments to improve their quality of life.

PowerVision, Inc. is a company that specializes in the development of innovative intraocular lenses aimed at restoring vision for individuals suffering from presbyopia and cataracts. Founded in 2002 and based in Belmont, California, PowerVision has created the FluidVision accommodating intraocular lens, which utilizes a unique fluid-controlled mechanism to mimic the natural function of a healthy eye. This technology allows users to dynamically adjust their focus for clear vision at all distances, potentially liberating millions from the need for glasses or other vision correction methods. The FluidVision lens is designed to meet the clinical and lifestyle needs of patients, offering a significant advancement in vision correction surgery. PowerVision's approach addresses the visual impairments faced by over 20 million people in the United States with cataracts and more than 90 million individuals affected by presbyopia, particularly those in their 40s and 50s.

PEAK Surgical is a medical device company based in Palo Alto, California, focused on developing surgical tools that enhance precision and control during surgical procedures. The company's flagship product, the PEAK Surgery System, includes a range of disposable cutting devices designed to provide the accuracy of a scalpel combined with the bleeding control typical of traditional electrosurgery, while minimizing collateral damage to surrounding tissues. This innovative technology addresses a significant need in the surgical market, making it suitable for various applications, including general, plastic, reconstructive, ENT, gynecologic, orthopedic, arthroscopic, spinal, and neurological surgeries in the United States, as well as general surgery in the European Union.

Salient Surgical Technologies, Inc., established in 1999, is a privately held medical technology company that specializes in advanced energy devices for surgical procedures. Initially focusing on monopolar electrosurgical devices for liver cancer treatment, the company has since developed the AQUAMANTYS® System, which features bipolar electrosurgical technology. This system is designed to minimize surgical blood loss through its patented TRANSCOLLATION® technology, which enables the haemostatic sealing of soft tissue and bone. The AQUAMANTYS System is utilized in various surgeries, including orthopaedic reconstruction, spine surgery, orthopaedic trauma, and surgical oncology. Salient's products are distributed in the United States, Europe, and Asia, benefiting hospitals, healthcare providers, and patients by enhancing clinical outcomes and reducing costs. To date, over 500,000 patients have undergone treatment using TRANSCOLLATION technology.

Spinal Modulation, Inc., based in Menlo Park, California, specializes in the research and development of medical devices aimed at treating chronic pain. With a significant portion of the adult population affected by severe chronic pain and limited treatment options available, the company addresses this critical healthcare challenge through its Axium Neurostimulator System. This next-generation intraspinal neuromodulation therapy specifically targets the dorsal root ganglion (DRG) to deliver electrical pulses that disrupt pain signals before they reach the brain. The system has demonstrated effectiveness in managing chronic intractable leg pain and other complex pain areas, such as the back and foot, providing a tailored approach for pain relief. By allowing adjustments to focus on either broad or specific pain areas, Spinal Modulation's technology aims to enhance patient comfort and reduce the adverse effects commonly associated with traditional spinal cord stimulators.

PhysioSonics, a development-stage device company based in Washington, focuses on ultrasound imaging to monitor blood flow in the brain.

Ardian is a privately held, clinical-stage medical device company that develops catheter-based therapies for hypertension treatment and related conditions. It develops a catheter system that uses radio-frequency energy to “deactivate” sympathetic nerves in the kidneys, lowering blood pressure. The company's flagship product, the Symplicity Catheter System, addresses uncontrolled hypertension through renal denervation, or ablation of the nerves lining the renal arteries. It has received the CE (Conformité Européene) mark and Australia's Therapeutic Goods Administration (TGA) listing but is not yet approved by the U.S. Food and Drug Administration (FDA).

Osteotech is focused on the development, manufacturing, and marketing of biologic, biomaterial, and device systems for musculoskeletal surgeries. It facilitates spinal, trauma, and total joint revision procedures. Osteotech was acquired by Medtronic in November 2010. It was founded in 1986 in Eatontown, New Jersey.

Intersect ENT, Inc. is a medical device company focused on developing innovative therapies for patients with ear, nose, and throat conditions. Founded in 2003 and headquartered in Menlo Park, California, the company specializes in drug delivery products aimed at enhancing treatment outcomes for chronic sinusitis and other related ailments. Its key offerings include the PROPEL and PROPEL mini drug-releasing implants, designed for patients undergoing sinus surgery, as well as the PROPEL Contour implant, which targets frontal and maxillary sinus ostia. Additionally, Intersect ENT provides SINUVA, a steroid-releasing implant intended for use in a physician office setting to address refractory disease. The company was previously known as Sinexus, Inc. before rebranding in 2009.