Medtronic

CathWorks Ltd. is a medical technology company based in Kfar-Saba, Israel, with an additional office in the United States. Founded in 2013, CathWorks specializes in developing advanced medical devices for the interventional cardiology market. The company's innovative technology leverages computational science and automatic multi-layered algorithms to enhance the utility of coronary angiography data, transforming visual assessments into objective decision-making tools for physicians. Its flagship product, CathWorks FFRangio, is a non-invasive device that provides objective multi-vessel physiological measurements, aimed at optimizing and confirming intra-procedural decisions for percutaneous coronary interventions (PCI). CathWorks is privately held and benefits from strong partnerships and support from leading venture capital firms in the medical devices sector.

Beijing Surgerii Technology Co., Ltd. specializes in the research, development, production, and sale of minimally invasive surgical robot systems in China. Founded in 2014 and based in Beijing, the company focuses on innovative technologies, particularly the next generation of flexible continuum robotic arms. Surgerii Technology aims to transform clinical practices through its single-hole and porous laparoscopic robot systems, enhancing the standard of care in minimally invasive surgeries. With a commitment to independent research and development, the company leverages its expertise in system design and integration to advance the medical equipment industry in China.

Orchestra BioMed, Inc. is a biomedical innovation company established in 2017 and located in New Hope, Pennsylvania. The company is dedicated to developing high-impact therapeutic solutions for medical procedures, with a primary focus on addressing cardiovascular diseases, which account for a significant number of global fatalities annually. Orchestra BioMed aims to accelerate the commercialization of its products through strategic partnerships with medical device companies. Its leading product candidates include BackBeat Cardiac Neuromodulation Therapy, designed for hypertension treatment, and Virtue Sirolimus AngioInfusion Balloon, which targets atherosclerotic artery disease. By emphasizing evidence-based solutions, Orchestra BioMed seeks to improve patient outcomes for serious medical conditions.

Titan Medical Inc. is a research and development stage company based in Toronto, Canada, that specializes in the design and development of robotic surgical technologies for minimally invasive surgery (MIS). The company's primary focus is on the SPORT Surgical System, a single-port robotic surgical system that features a surgeon-controlled patient cart equipped with a 3D high-definition vision system and multi-articulating instruments. This system allows surgeons to perform a variety of MIS procedures, including those related to gynecologic, urologic, colorectal, and abdominal conditions. The SPORT Surgical System includes an ergonomic surgeon workstation that provides a 3D endoscopic view of the surgical area, enhancing the overall surgical experience and precision.

Beijing Surgerii Technology Co., Ltd. specializes in the research, development, production, and sale of minimally invasive surgical robot systems in China. Founded in 2014 and based in Beijing, the company focuses on innovative technologies, particularly the next generation of flexible continuum robotic arms. Surgerii Technology aims to transform clinical practices through its single-hole and porous laparoscopic robot systems, enhancing the standard of care in minimally invasive surgeries. With a commitment to independent research and development, the company leverages its expertise in system design and integration to advance the medical equipment industry in China.

Rockley Photonics Limited, founded in 2013 and headquartered in Pasadena, California, specializes in the development of silicon photonics technologies for various applications, including data communications and consumer products. The company manufactures photonic chips and custom integrated packaged products, focusing on both chipset sales and customer-specific designs. Rockley Photonics integrates its research and development efforts to create a comprehensive range of optical modules that include supporting electronics, software, application algorithms, and AI platforms. These offerings are tailored for high-volume applications across dynamic and growing market sectors, demonstrating the company's commitment to innovation in photonics technology.

Intersect ENT is a medical device company focused on developing innovative therapies for patients with ear, nose, and throat conditions in the United States. The company specializes in drug delivery products, including the PROPEL and PROPEL mini drug-releasing implants, designed for individuals undergoing sinus surgery to address chronic sinusitis. Additionally, it offers PROPEL Contour, a steroid-releasing implant aimed at treating frontal and maxillary sinus ostia. Intersect ENT also provides SINUVA, a steroid-releasing implant intended for use in the physician's office for patients with refractory disease. Founded in 2003 and headquartered in Menlo Park, California, the company was previously known as Sinexus before rebranding in 2009.

Scivita Medical is a technology-focused enterprise specializing in optical diagnosis and treatment, as well as the development of multidimensional imaging and high-performance materials for minimally invasive medical procedures. The company offers a range of products, including flexible and rigid endoscopes, designed to enhance the capabilities of medical professionals. Its product lineup features advanced technologies such as ultra-high-definition visualization, 3D imaging, and fluorescence visualization, which facilitate precise diagnostics and treatments. Key offerings include a 4K medical endoscope camera system, integrated 4K-3D endoscope systems, and various single-use endoscopic devices for applications in gynecology, urology, and pulmonology. Scivita Medical aims to provide doctors with innovative tools that improve patient outcomes through enhanced visualization and minimally invasive techniques.

BrainsGate, Ltd., a medical device company, develops therapies for patients suffering from central nervous system (CNS) diseases. It offers a technology platform that involves electrical stimulation of the spheno-palatine ganglion (SPG), a nervous center known to increase cerebral blood flow. The company develops an ischemic stroke system that is based on an implantable electrode and is designed to deliver electrical stimulation to the spheno-palatine ganglion (SPG). Its system augments cerebral blood flow by using an external system temporarily attached to the patient’s cheek. BrainsGate, Ltd. was founded in 2000 and is based in Caesarea, Israel.

Ai Biomed is a technology that can detect the location of parathyroid tissue in real-time during surgical procedures, including during thyroidectomy and parathyroidectomy.

Triple Jump Medical is a developer of an insulin pump intended to treat diabetic patients.

BioProtect Ltd. is an international medical device startup focused on developing and commercializing biodegradable balloon spacers designed to protect normal tissue during cancer radiation therapy. The company's flagship product, the ProSpace balloon spacer, has demonstrated superior efficacy and safety in safeguarding the rectum during radiation treatment for prostate cancer. This innovative technology significantly reduces the risk of serious and chronic side effects associated with radiation, while enhancing tumor control. Founded in 2004 and headquartered in Israel, BioProtect also operates subsidiaries in Germany and the United States, aiming to address unmet clinical needs in the growing radiotherapy spacers market with its platform of biodegradable implantable balloons.

Companion Medical develops products to improve healthcare with easy-to-use medical devices that utilize state-of-the-art technologies. It has experience in medical devices and critical systems development, and its team is positioned to introduce exciting new medical products that improve and facilitate patient care. The company’s initial products focus on providing improved care to insulin using Diabetics.

Sinovation (Beijing) Medical Technology Co., Ltd. is a Beijing-based company that specializes in the research, development, production, and sale of medical devices. The company is dedicated to advancing medical robot technology and innovating intelligent medical products. Sinovation Medical's offerings include surgical robots that utilize clinical computer vision technology to enhance precision in medical procedures. These products are primarily designed for neurosurgical applications, addressing conditions such as epilepsy, Parkinson's disease, cerebral hemorrhage, and intracranial tumors. By providing reliable medical robotics, Sinovation aims to improve care for patients and support healthcare professionals in delivering effective treatment.

Medicrea International SA specializes in the design, manufacture, and distribution of spinal implants, operating both in France and internationally. Established in 1990 and headquartered in Rillieux-la-Pape, France, the company offers a comprehensive range of products, including various systems for thoraco-lumbar fixation, cervical interbody devices, and specialized implants for treating conditions such as scoliosis, degenerative diseases, and trauma. Notable product lines include the PASS series, which encompasses polyaxial and posterior fixation systems, as well as the IMPIX series, featuring sterile PEEK Optima cervical and lumbar interbody devices. Medicrea focuses on delivering innovative technologies aimed at improving patient outcomes and supporting healthcare professionals in surgical procedures. The company has been dedicated to advancing spinal care, leveraging over 18 years of experience in the field. As of late 2020, Medicrea operates as a subsidiary of Covidien Group S.a.r.l.

Digital Surgery is a privately-held pioneer in surgical artificial intelligence (AI), data and analytics, and digital education and training.

Stimgenics is a private company that pioneered a novel spinal cord stimulation waveform known as Differential Target Multiplexed (DTM) Spinal Cord Stimulation.

Klue, Inc. is a digital health technology company founded in 2016 and based in San Mateo, California. It specializes in developing artificial intelligence-based software that can recognize meals and analyze users' eating behaviors. Klue's innovative approach includes wearable technology aimed at addressing obesity by promoting healthier eating habits through real-time behavioral insights. As a subsidiary of Medtronic plc, Klue focuses on leveraging technology to empower individuals to make informed dietary choices and cultivate better eating patterns.

AV Medical is a company of medical devices that develops catheter-based interventions. It targets its flagship catheter, the Chameleon, to dialysis patients undergoing routine angioplasty procedures. It develops and commercializes the Chameleon PTA balloon catheter with its Supervision technology. The Chameleon catheter facilitates efficient angioplasty procedures and can potentially enhance both patient and operator safety. Experts have clinically he Chameleon has been clinically tested in various types of dialysis access procedures.

Saluda Medical Pty Ltd. is a medical device company focused on developing innovative solutions for the neuromodulation industry. The firm is known for its investigational device, Evoke, which features a closed-loop spinal cord stimulation system. This technology measures the spinal cord's response to stimulation and adjusts the stimulation parameters in real-time to optimize therapeutic outcomes for patients. Founded in 2010 and headquartered in Artarmon, Australia, with additional offices in Minnesota and the United Kingdom, Saluda Medical aims to provide effective treatment for chronic neuropathic pain. The company's unique approach involves monitoring each patient's neural fingerprint to automatically tailor electrical stimulation, ensuring that therapy is customized to meet individual needs. Saluda Medical's commitment to advancing medical technology is underpinned by a strong foundation of scientific research and a team of experienced professionals.

Titan Spine designs and manufactures interbody fusion devices for use in the cervical and lumbar spine. It offers Endoskeleton TL, a lateral fusion device for the lumbar spine; Endoskeleton TAS, an anterior lumbar interbody fusion (ALIF) interbody device with screws; Endoskeleton TA, a device for ALIF procedures; Endoskeleton TT, a device for transforaminal lumbar interbody fusion (TLIF) procedures; Endoskeleton TO, a device for posterior lumbar interbody fusion (PLIF) and oblique procedures; Endoskeleton TCS, a cervical interbody device with screws for anterior discectomy and fusion (ACDF); and Endoskeleton TC, a device for anterior discectomy and fusion (ACDF) procedures. Titan Spine serves patients in the United States and Europe through its sales force and a network of independent distributors. It has a strategic partnership with MBA. Kevin Gemas and Peter Ullrich founded Titan Spine in 2006. It has its headquarters in Mequon in Wisconsin with a location in Laichingen in Germany.

EPIX Therapeutics develops and manufactures products for use in electrophysiology based on microwave radiometry technology. Its products provide real-time feedback of energy delivered by catheters during cardiac ablation procedures. The company has a strategic relationship with Hansen Medical Inc. Advanced Cardiac Therapeutics, Inc. (ACT), a medical device company that designs and manufactures a catheter-based system for the treatment of patients with atrial fibrillation (AFIB), today announced it has changed its name to EPIX Therapeutics, Inc.

Nutrino Health Ltd. is a Tel Aviv-based company that specializes in developing a nutrition insights software platform, offering data services and analytics related to nutrition. Founded in 2011, Nutrino focuses on personalized dietary recommendations through its FoodPrint software, which analyzes individual biochemistry to provide tailored meal suggestions and health statistics. The platform integrates data from wearables and utilizes image recognition technologies to enhance its nutritional insights. Serving a diverse clientele, including individuals, businesses, and professionals, Nutrino operates as a subsidiary of Medtronic plc, emphasizing the intersection of body analytics and personalized nutrition.

Mazor Robotics Ltd. is a medical device company specializing in the development, production, and marketing of surgical technologies for orthopedics and neurosurgery. Established in 2000 and headquartered in Caesarea, Israel, the company focuses on computer-assisted surgery, enabling high-precision and minimally invasive procedures. Its flagship products include the Mazor X and the Renaissance guidance systems, which significantly enhance the accuracy of spinal surgeries, leading to improved clinical outcomes. These systems are designed to support complex surgical procedures while providing a safer environment for patients and medical staff. With the majority of its revenue generated in the United States, Mazor Robotics continues to innovate in the field of spine surgery, raising the standard of care in surgical practices.

MC10, Inc. specializes in developing and selling wearable medical sensors that capture clinical-grade biometric and physiological data for use in clinical trials. Founded in 2008 and based in Lexington, Massachusetts, the company offers several innovative products, including BioStamp nPoint, which processes raw data into clinical metrics such as vital signs and sleep patterns; Kintinuum, a rehabilitation device for orthopedic surgery; WiSP, which provides cardiac monitoring and ECG recording; and BioStampMD, a flexible sensor designed to conform to the human body for comprehensive data collection. The BioStamp system enhances data acquisition by allowing for discreet and comfortable wear, thus facilitating targeted measurements of muscle activation and movement. MC10's dedication to creating flexible, conformal electronics aims to improve the quality of life by seamlessly integrating technology with human activity.

Nanos Medical is engaged in the research and development, manufacturing and sales of disposable medical devices. The company's current core products are concentrated in the cardiovascular and ENT fields.

Yosemite Clinic is a multidisciplinary medical center located in Central Pudong, Shanghai, offering a wide range of walk-in services in a modern and well-equipped environment. The clinic provides specialties including family medicine, internal medicine, gynecology, pediatrics, rehabilitation, sports medicine, dentistry, ophthalmology, dermatology, and medical cosmetology. It is particularly noted for its focus on Minimally Invasive Surgery and Ambulatory Surgery. The facility is equipped with advanced medical imaging technology, including CT, X-ray, and ultrasound, alongside a fully operational laboratory and pharmacy. The clinic's diverse team of healthcare professionals hails from both China and around the world, allowing them to offer services in multiple languages such as English, Japanese, Malay, Mandarin Chinese, and Cantonese, ensuring comprehensive care for a diverse patient population.

VisionSense Corp. designs and develops advanced 3D-HD visualization systems specifically for minimally invasive surgeries. Its flagship products include the Visionsense VSiii system, which utilizes a stereoscopic camera for various surgical applications such as neurosurgery, ENT procedures, arthroscopy, and laparoscopy. Additionally, the Visionsense Iridium system provides inter-operative infrared fluorescence visualization to enhance surgical precision. The company's innovative technology offers depth perception and high-resolution imaging, allowing surgeons to navigate complex procedures with greater confidence and control. VisionSense serves medical centers globally, focusing on areas including neurosurgery, plastic and reconstructive surgery, and tumor margin visualization. Founded in 1998 and headquartered in Philadelphia, Pennsylvania, VisionSense operates additional offices in New York and Petah-Tikva, Israel, and functions as a subsidiary of Medtronic plc.

Fire1, based in Dublin, Ireland, is dedicated to developing innovative therapeutic devices aimed at enhancing the lives of heart failure patients. The company has created a remote monitoring system that allows healthcare providers to access real-time patient data and insights. This technology facilitates the early detection of complications associated with heart failure, enabling proactive interventions that can lead to improved patient outcomes. Through its focus on remote monitoring, Fire1 seeks to address critical challenges in heart failure management and contribute to better healthcare solutions.

AEGEA Medical is pioneering the application of its Adaptive Vapor Ablation technology to deliver therapies that provide high quality patient outcomes to a wider range of patients. AEGEA’s FDA approved water vapor technology enables the delivery of a safe and effective endometrial ablation for the treatment of menorrhagia in a simple, office-based procedure that takes only minutes. With a vision to expand safe and effective treatment options to more patients, and provide physicians with the confidence and convenience necessary to perform office-based procedures, AEGEA is inspiring new approaches to women’s healthcare. Founded in 2008, AEGEA Medical is located in in Menlo Park, California.

Crospon is developing edge minimally invasive medical devices for imaging and aiding surgery in the esophagus and stomach.

Semma Therapeutics, Inc. is focused on developing innovative cell therapies for patients with Type 1 diabetes, who traditionally rely on insulin injections. Founded based on groundbreaking research by Professor Douglas Melton, the company has licensed a method to generate functional, insulin-producing beta cells in the laboratory. Semma Therapeutics aims to combine these proprietary cells with advanced devices to create a comprehensive therapy that can replace the missing beta cells without the need for immunosuppression. By striving to bring this transformative treatment to clinical application, Semma Therapeutics seeks to significantly enhance the lives of diabetes patients. Headquartered in Cambridge, Massachusetts, the company is a subsidiary of Vertex Pharmaceuticals and collaborates strategically with Defymed.

Mazor Robotics Ltd. is a medical device company specializing in the development, production, and marketing of surgical technologies for orthopedics and neurosurgery. Established in 2000 and headquartered in Caesarea, Israel, the company focuses on computer-assisted surgery, enabling high-precision and minimally invasive procedures. Its flagship products include the Mazor X and the Renaissance guidance systems, which significantly enhance the accuracy of spinal surgeries, leading to improved clinical outcomes. These systems are designed to support complex surgical procedures while providing a safer environment for patients and medical staff. With the majority of its revenue generated in the United States, Mazor Robotics continues to innovate in the field of spine surgery, raising the standard of care in surgical practices.

SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for treating chronic inflammatory diseases, including rheumatoid arthritis and Crohn's Disease. The company leverages the Inflammatory Reflex, a natural mechanism that allows the central nervous system to regulate the immune system, which has been extensively studied and documented in scientific literature. SetPoint's proprietary microregulator aims to enhance this reflex through vagus nerve stimulation, offering an alternative treatment option that provides systemic anti-inflammatory effects. The devices are designed to supplement the body's natural responses and are expected to deliver comparable anti-inflammatory potency to leading medications, while potentially offering improved safety and lower costs. Currently, SetPoint is conducting human trials for its technology at multiple centers in Europe.

Glooko is a comprehensive diabetes management platform designed to enhance health outcomes for individuals with diabetes and their healthcare teams. It connects with various diabetes devices and fitness trackers to gather essential data, including glucose levels, food intake, insulin usage, medications, blood pressure, diet, and weight. The platform is utilized in over 7,000 clinical locations and serves more than 1.5 million people with diabetes across 23 countries and in 15 languages. Glooko aims to facilitate remote patient monitoring by providing healthcare providers with valuable insights and analytics, ultimately supporting interventions that improve patient care and promote healthier behaviors.

Earlens is a privately held medical technology company committed to transforming the hearing experience for millions of people who suffer from hearing loss.The company has developed the Earlens Contact Hearing Solution, which directly activates natural hearing, delivering the broadest bandwidth available today and superior sound quality. This revolutionary, non-surgical hearing solution uses a small lens to vibrate the eardrum, replicating the natural hearing process. The Earlens Contact Hearing Solution received FDA clearance in 2019 for a second generation of the Earlens technology. Unlike traditional hearing aids, which are in effect tiny speakers that simply turn up the volume on air conducted sound, the Earlens Contact Hearing Solution™ is the world’s first to deliver sound directly to the eardrum.

Saluda Medical Pty Ltd. is a medical device company focused on developing innovative solutions for the neuromodulation industry. The firm is known for its investigational device, Evoke, which features a closed-loop spinal cord stimulation system. This technology measures the spinal cord's response to stimulation and adjusts the stimulation parameters in real-time to optimize therapeutic outcomes for patients. Founded in 2010 and headquartered in Artarmon, Australia, with additional offices in Minnesota and the United Kingdom, Saluda Medical aims to provide effective treatment for chronic neuropathic pain. The company's unique approach involves monitoring each patient's neural fingerprint to automatically tailor electrical stimulation, ensuring that therapy is customized to meet individual needs. Saluda Medical's commitment to advancing medical technology is underpinned by a strong foundation of scientific research and a team of experienced professionals.

Semma Therapeutics, Inc. is focused on developing innovative cell therapies for patients with Type 1 diabetes, who traditionally rely on insulin injections. Founded based on groundbreaking research by Professor Douglas Melton, the company has licensed a method to generate functional, insulin-producing beta cells in the laboratory. Semma Therapeutics aims to combine these proprietary cells with advanced devices to create a comprehensive therapy that can replace the missing beta cells without the need for immunosuppression. By striving to bring this transformative treatment to clinical application, Semma Therapeutics seeks to significantly enhance the lives of diabetes patients. Headquartered in Cambridge, Massachusetts, the company is a subsidiary of Vertex Pharmaceuticals and collaborates strategically with Defymed.

Forerunner Medical (Shanghai) Co., Ltd. develops and manufactures medical devices for minimally invasive treatment. It primarily develops and produces low-temperature plasma radiofrequency generators and electrodes for sport medicine, disk demo-pression, and ENT treatment applications. Its products include plasma radiofrequency systems; and electrodes for joint, spine, cervical, lumbar, transforaminal endoscopic operation, and ENT treatment applications. The company was founded in 2009 and is based in Shanghai, China.

Inspire Medical Systems, Inc., a medical technology company, focuses on the development and commercialization of minimally invasive solutions for patients with obstructive sleep apnea (OSA). It offers Inspire system, a neurostimulation technology that provides a safe and effective treatment for moderate to severe OSA. The company also develops a novel, a closed-loop solution that continuously monitors a patient’s breathing and delivers mild hypoglossal nerve stimulation to maintain an open airway. Inspire Medical Systems, Inc. was founded in 2007 and is headquartered in Golden Valley, Minnesota.

MD Start SA is a Swiss-based incubator and fund focused on the medical technology sector, established in 2009. The company specializes in transforming innovative medical ideas into viable business ventures, providing comprehensive support from project creation to operational development. It partners with prominent organizations in the industry, including Medtronic and Sofinnova Partners, to facilitate the growth of medical device start-ups. By employing both strategic and hands-on approaches, MD Start aims to guide these projects through the investment stage and into commercial development, helping to bring new medical technologies to market.

Mazor Robotics Ltd. is a medical device company specializing in the development, production, and marketing of surgical technologies for orthopedics and neurosurgery. Established in 2000 and headquartered in Caesarea, Israel, the company focuses on computer-assisted surgery, enabling high-precision and minimally invasive procedures. Its flagship products include the Mazor X and the Renaissance guidance systems, which significantly enhance the accuracy of spinal surgeries, leading to improved clinical outcomes. These systems are designed to support complex surgical procedures while providing a safer environment for patients and medical staff. With the majority of its revenue generated in the United States, Mazor Robotics continues to innovate in the field of spine surgery, raising the standard of care in surgical practices.

HeartWare International, Inc. develops and manufactures small implantable heart pumps or ventricular assist devices for the treatment of advanced heart failure. The company offers HeartWare Ventricular Assist System, which includes a left ventricular assist device, or blood pump, patient accessories, and surgical tools designed to provide circulatory support for patients in the advanced stage of heart failure. It is also developing the Miniaturized Ventricular Assist Device, a miniaturized device intended for chronic heart failure patients. HeartWare International, Inc. sells and markets its products through clinical studies in the United States, as well as directly to cardiac centers and hospitals internationally. The company is headquartered in Framingham, Massachusetts.

Earlens is a privately held medical technology company committed to transforming the hearing experience for millions of people who suffer from hearing loss.The company has developed the Earlens Contact Hearing Solution, which directly activates natural hearing, delivering the broadest bandwidth available today and superior sound quality. This revolutionary, non-surgical hearing solution uses a small lens to vibrate the eardrum, replicating the natural hearing process. The Earlens Contact Hearing Solution received FDA clearance in 2019 for a second generation of the Earlens technology. Unlike traditional hearing aids, which are in effect tiny speakers that simply turn up the volume on air conducted sound, the Earlens Contact Hearing Solution™ is the world’s first to deliver sound directly to the eardrum.

Responsive Orthopedics LLC is a Minneapolis-based company that designs and develops knee implant systems, with a focus on providing low-cost hip and knee replacements. Established in 2013, the company offers logistical support to physician practices and hospitals, catering specifically to healthcare providers involved in federal programs aimed at reducing the costs associated with hip and knee procedures. In June 2016, Responsive Orthopedics became a subsidiary of Medtronic plc, further bolstering its capabilities in the healthcare marketplace. The company’s commitment to affordability and support positions it as a significant player in the orthopedic implant sector.

Gynaecology has been rapidly built around Smith & Nephew's resection technologies and comprises, primarily, the TRUCLEAR◊ System for the hysteroscopic resection and removal of uterine tissue. Gynaecology delivered revenue of $56 million in 2015, representing a little over 1% of Group revenue.

Bellco S.r.l. is an Italian company that specializes in medical devices for renal care, focusing on the treatment of renal failure, multiple organ failure, sepsis, and congestive heart failure. Founded in 1972 and headquartered in Mirandola, Italy, the company offers a wide range of products, including haemodiafiltration therapies, dialysis machines, haemodialysers, blood lines, catheters, concentrates, and sorbent cartridges. Bellco also develops therapeutic systems for acute patients in intensive care, as well as for neonatal patients. The company's commitment to innovation and research enables it to address the evolving needs of patients and healthcare professionals in nephrology, intensive care, and cardiology. It markets its products directly in Italy and has a presence in various countries through branches and distributors, including France, Spain, Belgium, Brazil, China, and Canada. Bellco operates as a subsidiary of Medtronic plc.

Aircraft Medical Limited develops and produces hand held medical devices. It offers McGRATH, a portable video laryngoscope. The company specializes in anesthesia and critical care products. It markets its products through distribution partners in the United States, Canada, the United Kingdom, Ireland, Italy, France, Denmark, Sweden, Norway, Benelux, and Australasia. Aircraft Medical Limited was formerly known as Smartscope MD Ltd. and changed its name to Aircraft Medical Limited in February 2004. The company was founded in 2001 and is based in Edinburgh, the United Kingdom. As of November 18, 2015, Aircraft Medical Limited operates as a subsidiary of Medtronic plc.

Lazarus Effect is a medical device company based in Campbell, California, dedicated to creating innovative interventional devices aimed at the removal of blood clots. The company is developing a comprehensive range of vascular-device products utilizing a patented wire-frame technology platform. Lazarus Effect holds five issued U.S. patents and has several pending patent applications both domestically and internationally. Notable products include the Lazarus Funnel™ Guide Catheter and Lazarus ReCover devices, which have received CE Mark approval for use in Europe, while the Funnel device is also cleared for use in the United States. The Lazarus Cover is currently awaiting CE Mark approval. However, neither the ReCover nor the Cover devices are authorized for sale in the United States at this time.

SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for treating chronic inflammatory diseases, including rheumatoid arthritis and Crohn's Disease. The company leverages the Inflammatory Reflex, a natural mechanism that allows the central nervous system to regulate the immune system, which has been extensively studied and documented in scientific literature. SetPoint's proprietary microregulator aims to enhance this reflex through vagus nerve stimulation, offering an alternative treatment option that provides systemic anti-inflammatory effects. The devices are designed to supplement the body's natural responses and are expected to deliver comparable anti-inflammatory potency to leading medications, while potentially offering improved safety and lower costs. Currently, SetPoint is conducting human trials for its technology at multiple centers in Europe.

Medtronic is a leading global company based in the United States, founded in 1949, that specializes in the development and manufacturing of medical technologies and therapies. The firm focuses on creating innovative solutions for chronic diseases and pain management, offering device-based treatments that aim to improve patient outcomes and enhance quality of life. Medtronic's extensive range of products and services addresses various health conditions, demonstrating its commitment to advancing healthcare technology. In addition to its core business, Medtronic also manages venture capital initiatives, such as the Suzhou Medtronic RMB Fund, which aims to invest in healthcare innovations in China. The company is dedicated to delivering lifelong solutions for individuals suffering from chronic health issues.

Twelve manufactures medical devices. It was formerly known as Foundry Newco XII, Inc. The company was incorporated in 2009 and is based in Menlo Park, California.

RF Surgical Systems, Inc. is the market leader in the detection and prevention of retained surgical sponges. The RF Surgical Detection System is the preferred solution in more than 1,500 operating rooms, trauma and labor and delivery suites nationwide. Since January 2011, more than 70 hospitals and surgical centers have joined the fast-growing list of care providers using RF Surgical Technology. RF Surgical Systems is based in Bellevue, Washington with R & D facilities in San Diego, California. The advanced technologies used in the RF Surgical Detection System are protected by U.S. patents. Regulatory clearance to market the system was granted by the U.S. Food and Drug Administration in November 2006.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, specializing in non-invasive cardiac mapping systems. The company has developed a technology known as Electrocardiographic Mapping (ECM), which produces three-dimensional images of the heart's electrical activity. This innovative system integrates body surface electrical data with anatomical data from CT scans, allowing for real-time visualization of cardiac electrical activity. The process involves the use of a single-use, disposable multi-sensor vest that captures electrical signals from the body, which are then processed by software to create detailed epicardial 3D electroanatomic maps and virtual electrograms. CardioInsight's technology aims to enhance the accuracy of diagnosing and treating various heart conditions, particularly arrhythmias and congestive heart failure. The effectiveness of ECM has been validated through more than 260 patient studies. Since 2015, CardioInsight has operated as a subsidiary of Medtronic plc.

Aptus Endosystems, Inc. is a medical device company focused on developing, manufacturing, and distributing innovative solutions for endovascular aneurysm repair (EVAR). Established in 2002 and headquartered in Sunnyvale, California, the company specializes in advanced technologies for treating aortic aneurysms, particularly through its Heli-FX EndoAnchor system, which provides a durable alternative to open surgical repair. This system utilizes unique helical staple technology for effective endograft fixation, enabling minimally invasive treatment options that maintain the control associated with open surgery. Aptus also offers the Aptus TourGuide, a steerable sheath designed for efficient access and delivery of peripheral vascular products. The company's products are available in several countries, including the United States, Germany, Italy, the Netherlands, and the United Kingdom, primarily through distributors.

AEGEA Medical is pioneering the application of its Adaptive Vapor Ablation technology to deliver therapies that provide high quality patient outcomes to a wider range of patients. AEGEA’s FDA approved water vapor technology enables the delivery of a safe and effective endometrial ablation for the treatment of menorrhagia in a simple, office-based procedure that takes only minutes. With a vision to expand safe and effective treatment options to more patients, and provide physicians with the confidence and convenience necessary to perform office-based procedures, AEGEA is inspiring new approaches to women’s healthcare. Founded in 2008, AEGEA Medical is located in in Menlo Park, California.

Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Established in 2006, it develops advanced diagnostic technology solutions for assessing spinal instability. The company offers the KineGraph Vertebral Motion Analyzer, an automated system that utilizes fluoroscopy to capture spine motion, generating patient-specific graphs that aid clinicians in diagnosing and treating back and neck pain. Additionally, Ortho Kinematics provides cloud-based analysis of instability testing results along with video X-ray imaging services through its imaging center. The company's innovations support spine clinicians by delivering critical insights into spinal health.

DreaMed Diabetes, Ltd. is an Israeli company founded in 2014 that specializes in developing innovative solutions for diabetes treatment and management. The company is known for its Glucositter, a closed-loop insulin delivery system designed to monitor glucose levels in real-time and adjust insulin delivery accordingly. DreaMed Diabetes has made significant advancements in the field, including the commercialization of the first artificial pancreas technology and becoming the first company to receive FDA clearance for a decision support system that integrates data from continuous glucose monitors and insulin pumps. Its Advisor Pro software, developed by diabetes professionals, utilizes artificial intelligence to enable healthcare providers to quickly analyze patient data and recommend optimal treatment plans. This technology facilitates frequent insulin titration adjustments and online monitoring, ultimately improving patient outcomes by lowering A1C levels and reducing complications. DreaMed Diabetes aims to provide patient-centered care, ensuring that all individuals with diabetes receive high-quality treatment regardless of their location or healthcare provider.

Diabeter B.V. is a diabetes clinic and research center located in Rotterdam, the Netherlands. The organization focuses on providing specialized care for individuals with diabetes, employing innovative approaches to treatment and management. Since April 2015, Diabeter has operated as a subsidiary of Medtronic, a global leader in medical technology. Through its clinical and research activities, Diabeter aims to improve diabetes care and outcomes for patients, contributing to advancements in diabetes management.

Sophono, Inc. is a medical device manufacturer based in Boulder, Colorado, specializing in implantable magnetic bone conduction hearing devices. Founded in 2009, the company focuses on providing solutions for individuals with conductive hearing loss, mixed hearing loss, and single-sided deafness. Its flagship product, the Alpha 2 MPO, offers an abutment-free experience, allowing the device to be placed under the skin while using magnets for external sound processing. Sophono distributes its products primarily through clinics, aiming to improve the quality of life for patients suffering from severe to profound hearing impairment. In 2015, the company became a subsidiary of Medtronic plc, further enhancing its capabilities in the medical device sector.

Semma Therapeutics, Inc. is focused on developing innovative cell therapies for patients with Type 1 diabetes, who traditionally rely on insulin injections. Founded based on groundbreaking research by Professor Douglas Melton, the company has licensed a method to generate functional, insulin-producing beta cells in the laboratory. Semma Therapeutics aims to combine these proprietary cells with advanced devices to create a comprehensive therapy that can replace the missing beta cells without the need for immunosuppression. By striving to bring this transformative treatment to clinical application, Semma Therapeutics seeks to significantly enhance the lives of diabetes patients. Headquartered in Cambridge, Massachusetts, the company is a subsidiary of Vertex Pharmaceuticals and collaborates strategically with Defymed.

Glooko is a comprehensive diabetes management platform designed to enhance health outcomes for individuals with diabetes and their healthcare teams. It connects with various diabetes devices and fitness trackers to gather essential data, including glucose levels, food intake, insulin usage, medications, blood pressure, diet, and weight. The platform is utilized in over 7,000 clinical locations and serves more than 1.5 million people with diabetes across 23 countries and in 15 languages. Glooko aims to facilitate remote patient monitoring by providing healthcare providers with valuable insights and analytics, ultimately supporting interventions that improve patient care and promote healthier behaviors.

Advanced Uro-Solutions is a company that specializes in the development and manufacturing of medical devices aimed at treating various health conditions. One of its primary products is the NURO percutaneous tibial nerve stimulation system, which includes a small external stimulator and a reusable lead designed to provide temporary stimulation to the tibial nerve. This technology is particularly focused on addressing urinary urgency and incontinence, as well as bowel control disorders. Additionally, the company explores solutions for cardiac rhythm disorders and neurological conditions, contributing to a broader spectrum of healthcare needs.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to assist presbyopic patients in restoring their near vision while preserving distance clarity. Additionally, AcuFocus provides the IC-8 IOL, a small aperture lens that accommodates a range of vision for cataract patients. The AcuTarget HD system serves as a diagnostic and surgical planning tool, aiding in the optimal treatment selection for various eye conditions, including LASIK and dry eye. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, thereby serving a global clientele of physicians and patients. Founded in 2001, AcuFocus continues to focus on advancing solutions for presbyopia and related vision issues.

Founded by Dr. Eugenio Cremascoli, the main business of NGC Medical Focuses are: Project planning, manufacturing and marketing of medical and surgical devices Import and distribution in national territory of medical devices, medical data management systems, medical communications database for remote access and medical equipment Design and turnkey implementation of Surgery Units, Intensive Care, Hemodynamics, Electrophysiology and Intervention Radiology Laboratories In-service management of Surgical Suites, Intensive Care, Hemodynamics, Electrophysiology and Intervention Radiology Laboratories Design and implementation of Information Management Software packages unifying the administrative and clinical departments within at single interface

Sapiens Steering Brain Stimulation GmbH is a medical device company focused on advancing deep brain stimulation (DBS) therapy. Founded in 2011 as a spin-out of Royal Philips Electronics, the company aims to enhance patient comfort and therapeutic outcomes with its innovative, high-resolution, and MRI-compatible DBS system. Sapiens specializes in developing a comprehensive DBS solution that includes navigation and steering software, as well as implants specifically designed for patients with Parkinson's disease. With offices in Eindhoven, the Netherlands, and Munich, Germany, Sapiens leverages patented technologies to deliver effective and precise treatment options for individuals suffering from this neurological condition.

Visualase, Inc., founded in 2005 as a spin-off from BioTex, Inc., is a privately held company based in Houston, Texas. It specializes in developing laser and image-guided technologies specifically for thermal ablation applications. The company has created innovative tools designed for the treatment of cancer and other malignancies, utilizing advanced laser and MRI-based guidance systems to enhance precision and effectiveness in medical procedures.

Covidien plc is a global leader in the development, manufacture, and sale of healthcare products designed to enhance patient outcomes and reduce healthcare delivery costs. The company operates through four main segments: Medical Devices, Imaging Solutions, Pharmaceutical Products, and Medical Supplies. The Medical Devices segment includes a wide range of products such as endomechanical instruments, soft tissue repair solutions, energy devices, and monitoring products. Imaging Solutions focuses on radiopharmaceuticals and contrast agents, while the Pharmaceutical Products segment develops dosage pharmaceuticals and active ingredients. Additionally, the Medical Supplies segment encompasses nursing care products and surgical supplies. By collaborating with medical professionals, Covidien aims to improve the quality of life for patients and deliver effective healthcare solutions across clinical and home settings.

Corventis is committed to improving clinical outcomes and lowering healthcare costs by enabling the early detection of cardiovascular events while allowing patients to maintain an active lifestyle.

Inspire Medical Systems, Inc., a medical technology company, focuses on the development and commercialization of minimally invasive solutions for patients with obstructive sleep apnea (OSA). It offers Inspire system, a neurostimulation technology that provides a safe and effective treatment for moderate to severe OSA. The company also develops a novel, a closed-loop solution that continuously monitors a patient’s breathing and delivers mild hypoglossal nerve stimulation to maintain an open airway. Inspire Medical Systems, Inc. was founded in 2007 and is headquartered in Golden Valley, Minnesota.

PowerVision, Inc. is a company that specializes in the development of innovative accommodating intraocular lens technology aimed at restoring vision for individuals affected by presbyopia and cataracts. Based in Belmont, California, PowerVision's flagship product, the FluidVision intraocular lens, utilizes a small amount of fluid within the lens to mimic the natural functioning of a healthy eye, allowing users to dynamically adjust their focus for clear vision at all distances. This technology is designed to address the vision needs of millions, particularly the elderly, who suffer from cataracts and the age-related loss of near vision associated with presbyopia. By offering a solution that potentially eliminates the need for glasses or other forms of vision correction, PowerVision aims to significantly improve the quality of life for those facing these common age-related vision challenges. The company was incorporated in 2002 and was acquired by Alcon Laboratories, Inc. in March 2019.

TyRx engages in the design, development, and commercialization of resorbable polymeric biomaterials. It offers PIVIT CRM, a mesh based pouch, which contains antibacterial agents to help provide protection from microbial colonization of the generator or defibrillator during and immediately after surgical implant. The company also provides AIGISRx Flat, an antibacterial product that provides protection against infections associated with implanted pacemakers and defibrillators. TyRx Pharma, Inc. was formerly known as Advanced Materials Design, LLC. The company was founded in 1997 and is based in Monmouth Junction, New Jersey.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, specializing in non-invasive cardiac mapping systems. The company has developed a technology known as Electrocardiographic Mapping (ECM), which produces three-dimensional images of the heart's electrical activity. This innovative system integrates body surface electrical data with anatomical data from CT scans, allowing for real-time visualization of cardiac electrical activity. The process involves the use of a single-use, disposable multi-sensor vest that captures electrical signals from the body, which are then processed by software to create detailed epicardial 3D electroanatomic maps and virtual electrograms. CardioInsight's technology aims to enhance the accuracy of diagnosing and treating various heart conditions, particularly arrhythmias and congestive heart failure. The effectiveness of ECM has been validated through more than 260 patient studies. Since 2015, CardioInsight has operated as a subsidiary of Medtronic plc.

Cardiocom specializes in telemedicine solutions focused on daily remote patient monitoring and disease management. The company provides health professionals with telehealth devices and services designed to identify symptomatic patients and facilitate early interventions, thereby reducing unnecessary hospitalizations. Cardiocom's offerings address a range of chronic conditions, including congestive heart failure, chronic obstructive pulmonary disease, asthma, diabetes, hypertension, and obesity. The product lineup includes the Cardiocom OMNIVISOR PRO Patient Management System, TELESCALE for heart failure management, and COMMANDER for patients with multiple chronic diseases. By implementing Cardiocom's proactive solutions, healthcare organizations can enhance patient quality of life while achieving cost savings in health management.

MC10, Inc. specializes in developing and selling wearable medical sensors that capture clinical-grade biometric and physiological data for use in clinical trials. Founded in 2008 and based in Lexington, Massachusetts, the company offers several innovative products, including BioStamp nPoint, which processes raw data into clinical metrics such as vital signs and sleep patterns; Kintinuum, a rehabilitation device for orthopedic surgery; WiSP, which provides cardiac monitoring and ECG recording; and BioStampMD, a flexible sensor designed to conform to the human body for comprehensive data collection. The BioStamp system enhances data acquisition by allowing for discreet and comfortable wear, thus facilitating targeted measurements of muscle activation and movement. MC10's dedication to creating flexible, conformal electronics aims to improve the quality of life by seamlessly integrating technology with human activity.

Kanghui was founded in 1997 and is headquartered in Changzhou. Kanghui announced today that it requested that trading of its American depositary shares on the NYSE be suspended. Kanghui has requested that the NYSE file Form 25 with the U.S. Securities and Exchange Commission (the “SEC”) notifying the SEC of the delisting of Kanghui’s American depositary shares from NYSE and the deregistration of the Company’s registered securities. Kanghui intends to terminate its reporting obligations under the Securities Exchange Act of 1934, as amended by promptly filing Form 15 with the SEC.

Mitralign is a privately held company based in a suburb of Boston, Massachusetts, focused on developing a catheter-based technology for the treatment of functional mitral regurgitation. The company has created an innovative system that mimics surgical annuloplasty by delivering surgical implants directly into the mitral annulus via a catheter. This process involves cinching the implants together to decrease the size of the mitral valve annulus and the valve opening. Mitralign's technology aims to provide a less invasive option for managing this life-threatening cardiac condition, enabling healthcare providers to effectively treat symptomatic functional mitral regurgitation through tissue-plication. The company is supported by prominent venture capitalists and has attracted investments from major cardiovascular device firms.

Inspire Medical Systems, Inc., a medical technology company, focuses on the development and commercialization of minimally invasive solutions for patients with obstructive sleep apnea (OSA). It offers Inspire system, a neurostimulation technology that provides a safe and effective treatment for moderate to severe OSA. The company also develops a novel, a closed-loop solution that continuously monitors a patient’s breathing and delivers mild hypoglossal nerve stimulation to maintain an open airway. Inspire Medical Systems, Inc. was founded in 2007 and is headquartered in Golden Valley, Minnesota.

Visualase, Inc., founded in 2005 as a spin-off from BioTex, Inc., is a privately held company based in Houston, Texas. It specializes in developing laser and image-guided technologies specifically for thermal ablation applications. The company has created innovative tools designed for the treatment of cancer and other malignancies, utilizing advanced laser and MRI-based guidance systems to enhance precision and effectiveness in medical procedures.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, specializing in non-invasive cardiac mapping systems. The company has developed a technology known as Electrocardiographic Mapping (ECM), which produces three-dimensional images of the heart's electrical activity. This innovative system integrates body surface electrical data with anatomical data from CT scans, allowing for real-time visualization of cardiac electrical activity. The process involves the use of a single-use, disposable multi-sensor vest that captures electrical signals from the body, which are then processed by software to create detailed epicardial 3D electroanatomic maps and virtual electrograms. CardioInsight's technology aims to enhance the accuracy of diagnosing and treating various heart conditions, particularly arrhythmias and congestive heart failure. The effectiveness of ECM has been validated through more than 260 patient studies. Since 2015, CardioInsight has operated as a subsidiary of Medtronic plc.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at enhancing near vision. The company offers the KAMRA inlay, designed to assist presbyopic patients in restoring their near vision while preserving distance clarity. Additionally, AcuFocus provides the IC-8 IOL, a small aperture lens that accommodates a range of vision for cataract patients. The AcuTarget HD system serves as a diagnostic and surgical planning tool, aiding in the optimal treatment selection for various eye conditions, including LASIK and dry eye. AcuFocus markets its products through distribution partners across the Americas, Asia-Pacific, Europe, and the Middle East, thereby serving a global clientele of physicians and patients. Founded in 2001, AcuFocus continues to focus on advancing solutions for presbyopia and related vision issues.

Functional Neuromodulation is a medical technology company that specializes in developing neuromodulation therapies aimed at treating Alzheimer's disease and other cognitive disorders. Established in 2010, the company is headquartered in Toronto, Canada, with an additional office in Minneapolis, Minnesota. Its primary offering is a deep brain stimulation (DBS) technology, which involves a surgically implanted device that delivers mild electrical pulses to specific areas of the brain. This approach is designed to enhance neural activity and modulate memory circuits, ultimately assisting patients in managing symptoms associated with memory and cognitive impairments. Through its innovative therapies, Functional Neuromodulation aims to improve the quality of life for individuals suffering from these challenging conditions.

PowerVision, Inc. is a company that specializes in the development of innovative accommodating intraocular lens technology aimed at restoring vision for individuals affected by presbyopia and cataracts. Based in Belmont, California, PowerVision's flagship product, the FluidVision intraocular lens, utilizes a small amount of fluid within the lens to mimic the natural functioning of a healthy eye, allowing users to dynamically adjust their focus for clear vision at all distances. This technology is designed to address the vision needs of millions, particularly the elderly, who suffer from cataracts and the age-related loss of near vision associated with presbyopia. By offering a solution that potentially eliminates the need for glasses or other forms of vision correction, PowerVision aims to significantly improve the quality of life for those facing these common age-related vision challenges. The company was incorporated in 2002 and was acquired by Alcon Laboratories, Inc. in March 2019.

PEAK Surgical is a medical device company based in Palo Alto, California, focused on developing surgical tools that combine the precision of a scalpel with the bleeding control typical of traditional electrosurgery. The company's flagship product, the PEAK Surgery System, includes a range of disposable cutting devices designed to minimize collateral damage during surgical procedures. This innovative system is approved for use in various surgical fields, including general, plastic and reconstructive, ENT, gynecologic, orthopedic, arthroscopic, spinal, and neurological surgeries in the United States, as well as general surgery in the European Union. PEAK Surgical aims to fill a critical gap in the surgical market by providing enhanced tools for physicians.

Salient Surgical Technologies, Inc., established in 1999, is a privately held medical technology company that specializes in advanced energy devices for surgical procedures. Initially focusing on monopolar electrosurgical devices for liver cancer treatment, the company has since developed the AQUAMANTYS® System, which features bipolar electrosurgical technology. This system is designed to minimize surgical blood loss through its patented TRANSCOLLATION® technology, which enables the haemostatic sealing of soft tissue and bone. The AQUAMANTYS System is utilized in various surgeries, including orthopaedic reconstruction, spine surgery, orthopaedic trauma, and surgical oncology. Salient's products are distributed in the United States, Europe, and Asia, benefiting hospitals, healthcare providers, and patients by enhancing clinical outcomes and reducing costs. To date, over 500,000 patients have undergone treatment using TRANSCOLLATION technology.

Spinal Modulation, Inc. provides medical devices research and development services. The company is based in Menlo Park, California. According to the 2002 Health Assessment on the Prevalence of Chronic Pain, severe chronic pain, as defined by the International Association for the Study of Pain, is prevalent in 10 to 13% of the adult population. Limited treatment options exist for these patients and the burden to the healthcare system is unsustainable. The Spinal Modulation AxiumTM Neurostimulator System is a next-generation intraspinal neuromodulation therapy that stimulates the dorsal root ganglion (DRG) to provide a new pain management option. It has shown promising results in managing chronic intractable leg pain, as well as difficult-to-target anatomies such as the back and foot. By stimulating the DRG, therapy can be adjusted to cover either broad or specific areas of pain throughout the torso and legs, while limiting uncomfortable postural effects typically experienced with other spinal cord stimulators.

PhysioSonics (Seattle, WA) a development-stage device company focused on ultrasound imaging to monitor blood flow in the brain.

Osteotech is focused on the development, manufacturing, and marketing of biologic, biomaterial, and device systems for musculoskeletal surgeries. It facilitates spinal, trauma, and total joint revision procedures. Osteotech was acquired by Medtronic in November 2010. It was founded in 1986 in Eatontown, New Jersey.

Intersect ENT is a medical device company focused on developing innovative therapies for patients with ear, nose, and throat conditions in the United States. The company specializes in drug delivery products, including the PROPEL and PROPEL mini drug-releasing implants, designed for individuals undergoing sinus surgery to address chronic sinusitis. Additionally, it offers PROPEL Contour, a steroid-releasing implant aimed at treating frontal and maxillary sinus ostia. Intersect ENT also provides SINUVA, a steroid-releasing implant intended for use in the physician's office for patients with refractory disease. Founded in 2003 and headquartered in Menlo Park, California, the company was previously known as Sinexus before rebranding in 2009.

Axon Systems is the designer and manufacturer of various NIM Eclipse nerve monitoring systems, which have been marketed and sold in the United States by the Spinal and Biologics business at Medtronic for the past three years. These devices are used in surgery to enhance patient safety by protecting delicate nerves during implant procedures. Axon Systems has introduced an impressive number of "firsts" in the field of neuromonitoring, including: 16 and 32 channel simultaneous multimodality systems, integrated transcranial MEP, microscope and vital signs views, and integrated TCD and pulse oximetery.

CardioMEMS is a medical device company that has developed and is commercializing a proprietary wireless sensing and communication technology for the human body. Their technology platform is designed to improve the management of severe chronic cardiovascular diseases such as heart failure and aneurysms. Their miniature wireless sensors can be implanted using minimally invasive techniques and transmit cardiac output, blood pressure and heart rate data that are critical to the management of patients.

ATS Medical is a medical device manufacturer specializing in cardiovascular surgery products. ATS is a global company with product sales in more than 40 countries across the globe and superior product performance in more than 80,000 mechanical heart valves implanted to date. The ATS Open Pivot® Heart Valve utilizes a unique design specifically intended to offer advantages to the surgeon and improved quality of life to the patient. Instead of cavities in the hinge area, which is the case in all other bileaflet heart valves, The ATS Open Pivot® Heart Valve has open pivots. This enables the leaflets to pivot on smooth spheres that project gently into the bloodstream. The unique configuration eliminates cavities and stagnant areas where blood may collect and clot. For more information about The ATS Open Pivot® Heart Valve, please visit the expanded discussion for patients, physicians, or investors.

Atreo Medical develops novel medical tools to aid in resuscitation. Its first product is a CPR assist device used to enhance the quality of CPR both in and out of hospital.

Krauth Cardiovascular

Invatec is a European company specializing in the development and commercialization of interventional products for coronary and peripheral vascular treatments. Established in 1996, Invatec collaborates closely with healthcare professionals to enhance patient outcomes and extend life expectancy through innovative medical solutions. The company’s expertise encompasses polymer processing, metallurgy, surface treatments, and drug coatings, allowing for the creation of a diverse range of products. With a portfolio that includes treatments for critical limb ischemia and carotid artery stenting, Invatec offers various drug-eluting balloons aimed at improving the long-term success of vascular interventions. Operated from its headquarters in Brescia, Italy, and Frauenfeld, Switzerland, Invatec maintains comprehensive in-house capabilities for product design, development, manufacturing, and assembly, distributing its 35 product families across more than 70 countries and employing approximately 900 individuals.

Fogazzi provides polymer technology.

Salient Surgical Technologies, Inc., established in 1999, is a privately held medical technology company that specializes in advanced energy devices for surgical procedures. Initially focusing on monopolar electrosurgical devices for liver cancer treatment, the company has since developed the AQUAMANTYS® System, which features bipolar electrosurgical technology. This system is designed to minimize surgical blood loss through its patented TRANSCOLLATION® technology, which enables the haemostatic sealing of soft tissue and bone. The AQUAMANTYS System is utilized in various surgeries, including orthopaedic reconstruction, spine surgery, orthopaedic trauma, and surgical oncology. Salient's products are distributed in the United States, Europe, and Asia, benefiting hospitals, healthcare providers, and patients by enhancing clinical outcomes and reducing costs. To date, over 500,000 patients have undergone treatment using TRANSCOLLATION technology.

GI Dynamics, Inc. is a medical device company that focuses on developing non-surgical therapies for the treatment of type 2 diabetes and obesity. The company's flagship product, EndoBarrier, is designed to help patients manage these conditions effectively. Founded in 2003, GI Dynamics is headquartered in Boston, Massachusetts, and markets its products primarily in Europe, the Middle East, the Asia Pacific, and South America. The company serves healthcare providers and third-party distributors, aiming to provide innovative solutions for metabolic diseases.

MicroCHIPS Biotech, Inc. specializes in developing a microchip-based implant designed for drug delivery applications across various therapeutic areas, including osteoporosis, diabetes, multiple sclerosis, women’s contraception, and pain management. This innovative implant can store and release precise doses of medication over extended periods, offering an alternative to traditional therapies that rely on frequent injections. The implant is surgically placed under the skin during a minimally invasive procedure and can be wirelessly activated or deactivated by healthcare providers or patients. Additionally, the device allows for real-time adjustments to the drug dosage and frequency, catering to the specific needs of each patient. Established in 1999 and headquartered in Lexington, Massachusetts, MicroCHIPS operates as a subsidiary of Daré Bioscience, Inc.