Northern Gritstone

Phlux Technology is a photonics company focused on developing advanced infrared sensing technology. Established in September 2020 as a spin-off from the University of Sheffield, Phlux aims to create high-performance infrared sensors designed for applications in LIDAR, fiber sensing, and imaging systems. The company's innovative approach seeks to provide affordable infrared sensors that enhance the performance of laser rangefinders and other optical systems, effectively bridging the performance gap between InGaAs single-photon avalanche diodes and conventional InGaAs avalanche photodiodes. By doing so, Phlux enables clients to significantly expand the capabilities of eye-safe sensor systems across various industries.

Robotics, teleoperation, software

Partful is a developer of software that creates 3D exploded views of products and parts, aimed at enhancing the efficiency of maintenance and repair operations. Its platform offers an interactive 3D experience, enabling users to quickly identify, locate, and order the correct parts. This functionality helps businesses reduce downtime, improve safety, and achieve cost savings. By presenting products in a visually engaging format, Partful facilitates a more effective approach to parts management and ordering.

Exciting Instruments Limited is a joint venture based in Sheffield, combining the software expertise of Bulldozer Limited with Dr. Timothy Craggs' specialization in single-molecule technology. The company develops advanced single-molecule spectroscopy instruments that facilitate the discovery processes in biophysics, life sciences, drug discovery, and medical diagnostics. Their bench-top instruments are designed for two-color, single-molecule fluorescence detection, enabling scientific researchers to conduct real-time data analysis and visualization. With a focus on cloud connectivity and innovative software solutions, Exciting Instruments aims to streamline research and enhance the capabilities of scientific inquiry.

Silveray specializes in the development of affordable large-area direct conversion detectors for the X-ray imaging market. The company employs advanced technology that utilizes nanoparticle-based X-ray conversion materials, produced as semiconductor ink, which are then deposited onto a pixel backplane. This innovative approach enables high-performance X-ray imaging and generates an electrical current in response to detected X-ray photons. By focusing on sustainability and cost-effectiveness, Silveray aims to enhance imaging capabilities for healthcare and various industries.

MicroLub produces a fat replacement for lower-calorie plant-based diets. It is cutting-edge innovation to the next generation of protein technology, creating exclusive ingredient solutions that significantly minimize molecular friction.

Phagenesis Limited is focused on developing medical device technology aimed at treating dysphagia, a condition that impairs swallowing, often resulting from strokes or brain injuries. The company's primary product, Phagenyx, consists of a base station that delivers electrical stimulations to the patient and records pertinent information, along with a catheter that is introduced through the nose to stimulate the pharynx. This innovative approach leverages the brain's ability to relearn lost functions through neuroplasticity, effectively aiding patients in regaining control over their swallowing mechanisms. Founded in 2007 and based in Manchester, United Kingdom, Phagenesis emphasizes research and evidence-based solutions, with foundational work led by Professor Shaheen Hamdy of the University of Manchester, whose findings have been published in prestigious medical journals.

Adsilico redefines medical device innovation.

PragmatIC specializes in ultra-low-cost flexible electronics, specifically through the development of flexible integrated circuits (FlexICs) that are thinner than human hair. These circuits can be invisibly embedded in various objects, allowing for innovative solutions to everyday challenges that traditional electronics cannot address effectively. The company offers a FlexIC Foundry service, enabling designers to create application-specific flexible devices at a reduced cost and time compared to conventional silicon circuits, thus opening new market opportunities. Additionally, PragmatIC provides standard FlexIC products that enhance established technologies like RFID and NFC for mass-market applications, paving the way for a vast array of smart objects capable of interacting with consumers and their environments. FlexICs are produced using the company's unique FlexLogIC production system, which allows for cost-effective, high-volume manufacturing with significantly lower capital and operational costs than traditional silicon fabrication. Headquartered in Cambridge, UK, PragmatIC serves a diverse range of industries, including consumer goods, retail, healthcare, and security, with a growing global clientele.

Floreon specializes in the development of a plant-based bioplastic that serves as an environmentally friendly alternative to traditional oil-based plastics. The company enhances standard polylactic acid (PLA) by incorporating a specially formulated compound, resulting in a high-performing, fully compostable material. Floreon's innovative approach was born from a commitment to creating a greener and safer plastic option, responding to the limitations of existing materials. After four years of collaboration with the University of Sheffield through a Knowledge Transfer Partnership, Floreon successfully introduced its unique product, which not only competes with conventional plastics in terms of performance but also significantly reduces the carbon footprint. This aligns with the sustainability goals of its clients by offering a range of end-of-life options for its bioplastic.

Pencil Biosciences is focused on creating an innovative genome modulation platform that addresses the limitations of existing gene-editing technologies. By developing a programmable tool for genome modulation, the company aims to provide new therapeutic options for patients suffering from rare diseases. This technology is designed to have a broad impact, allowing medical professionals to navigate the complexities of gene editing more effectively. Through its advancements, Pencil Biosciences seeks to enhance the capabilities of gene-editing applications in the medical field.

C-Capture Limited, founded in 2008 and based in Leeds, United Kingdom, specializes in the development and design of solvent systems for the removal of carbon dioxide (CO2) from gas streams. The company utilizes its expertise in CO2-based chemistry and engineering to create absorbents for reversible CO2 capture, particularly in post-combustion processes. C-Capture focuses on providing non-toxic and economically viable carbon capture solutions for emission sources, including flue gases from power generators and hard-to-abate industries. By offering innovative technology for capturing CO2, C-Capture aims to contribute to more sustainable electricity generation and address the environmental challenges posed by greenhouse gas emissions.

Mimetrik is a developing solution to real-world healthcare problems that are now unsolved or inadequately addressed.

AssetCool is a thermal metaphotonics company that specializes in the development of photonic coatings and materials aimed at optimizing the performance of electrical networks. Its innovative products are designed to reduce overhead line temperatures and increase conductor ampacity. By enhancing the functionality of electrical systems, AssetCool's solutions help users achieve greater ampacity in conventional overhead lines while simultaneously minimizing energy losses, costs, and carbon emissions. This focus on efficiency and sustainability positions AssetCool as a key player in the advancement of energy transmission technologies.

Optalysys Inc. is a technology company based in Reno, Nevada, that specializes in the development of optical coprocessors aimed at enhancing artificial intelligence systems and deep learning capabilities. Founded in 2013, the company focuses on utilizing low-power laser light to perform complex convolution functions, which significantly accelerates image classification and recognition tasks. This technology finds applications in various sectors, including autonomous vehicles for obstacle recognition, medical image analysis for diagnosing patient symptoms, and weather forecasting for predicting natural disasters. Optalysys's optical systems not only improve computational efficiency but also ensure data confidentiality through quantum secure encryption, making them suitable for sensitive applications such as genetic testing. Their innovative approach promises to deliver supercomputing capabilities for edge and mobile devices while consuming considerably less energy than traditional computing hardware.

LC AuxeTec is a materials company based on synthetic auxetic materials that enables resistance to high impact applications.

Recourse is a experiential skills development platform allows clinicians to immediately put theory into practice by simulating complex interactions with conversational digital humans. It support healthcare & life science organizations to achieve optimal performance.

Slingshot Simulations Limited operates a simulation-as-a-Service platform that facilitates the rapid simulation of complex large-scale systems. Founded in 2015 and based in Leeds, United Kingdom, the company specializes in providing scalable simulation and Digital Twin solutions for various businesses. Its software offers tools for automated configuration, deployment, management, and analysis of simulations, enabling organizations to enhance decision-making and commercialize research conducted by computer scientists. By leveraging cutting-edge technologies, Slingshot Simulations aims to streamline the simulation process and support businesses in navigating complex operational challenges.

QV Bioelectronics is focused on improving the lives of brain tumor patients through its innovative electric field therapy implant, GRACE. Developed in collaboration with leading neurosurgeons in the UK, GRACE aims to extend the life expectancy of glioblastoma patients, a group historically faced with limited treatment options and poor survival rates. Recognizing the urgent need for effective therapies, co-founders Dr. Richard Fu and Dr. Chris Bullock created a solution to address both the clinical and quality of life challenges faced by patients. The company has garnered nearly $1 million in funding from UK institutions, including Innovate UK, and over $1 million in equity funding from international life science investors. With a multidisciplinary team based in Alderley Park, Cheshire, QV Bioelectronics is dedicated to advancing GRACE from research to clinical application, utilizing cutting-edge materials science to enhance treatment outcomes for patients.

Phlux Technology is a photonics company focused on developing advanced infrared sensing technology. Established in September 2020 as a spin-off from the University of Sheffield, Phlux aims to create high-performance infrared sensors designed for applications in LIDAR, fiber sensing, and imaging systems. The company's innovative approach seeks to provide affordable infrared sensors that enhance the performance of laser rangefinders and other optical systems, effectively bridging the performance gap between InGaAs single-photon avalanche diodes and conventional InGaAs avalanche photodiodes. By doing so, Phlux enables clients to significantly expand the capabilities of eye-safe sensor systems across various industries.

Imperagen is a biotechnology research company specializing in enzyme engineering, artificial intelligence, and synthetic biology. The company focuses on developing a life science platform that integrates patented advancements in enzyme simulation, AI, and automation. By creating novel enzyme products, Imperagen aims to facilitate the manufacture of complex drug molecules for various applications, including laboratory tools, enzyme replacement therapies, and drug delivery systems. This innovative approach enables clients to obtain the desired drugs more efficiently and effectively.

Opteran focuses on reverse-engineering biological brains to develop neuromorphic software designed for machine autonomy. By leveraging insights gained from 600 million years of evolution, the company creates robust and cost-effective solutions that enable autonomous operations in challenging environments. The Opteran Mind is an integrated and modular platform that provides general-purpose autonomy without relying on artificial intelligence, data centers, or extensive training. This innovative approach allows clients to create autonomous machines capable of navigating complex spaces, performing tasks such as cleaning and servicing while ensuring safety around people.