Northern Gritstone

Phlux Technology is a photonics company that specializes in the development of advanced infrared sensing technology. Established in September 2020 as a spin-out from the University of Sheffield, Phlux focuses on creating high-performance infrared sensors designed for applications in LIDAR, fiber sensing, and imaging systems. The company aims to provide affordable infrared sensors that bridge the performance gap between InGaAs single-photon avalanche diodes (SPADs) and conventional InGaAs avalanche photodiodes (APDs). By enhancing the capabilities of laser rangefinders and other sensor systems, Phlux Technology enables clients to expand the operational limits of eye-safe sensor applications.

Robotics, teleoperation, software

Partful is a technology company that specializes in developing 3D explosion parts catalog and work instructions software. Its platform offers an interactive 3D experience, allowing consumers to visualize products and parts in detail. This innovative approach enables users to easily identify, locate, and order the correct components from a single exploded view. By streamlining the process of maintenance and repair operations, Partful's solutions help businesses reduce downtime, enhance safety, and achieve cost savings. The company's focus on improving operational efficiency through advanced visualization tools positions it as a valuable partner for organizations seeking to optimize their parts management processes.

Founded in Sheffield, Exciting Instruments combines software expertise from Bulldozer Limited with Dr. Timothy Craggs' single molecule knowledge to streamline discovery processes in biophysics, life sciences, drug discovery, and medical diagnostics. Their spectroscopy tool studies protein conformations and bimolecular interactions, offering real-time data analysis and visualization via cloud connectivity.

Silveray develops affordable large-area direct conversion detectors for the X-ray imaging market.

MicroLub develops fat-replacement and texture-enhancing protein technologies for reduced-fat and plant-based foods. It creates next-generation ingredients and microgels that minimize molecular friction to improve sensory performance, enabling smoother and creamier textures. Its patented protein-polysaccharide formulations have applications in the food and personal care industries, addressing sustainability and consumer needs by supporting lower-fat, appealing products.

Phagenesis develops a medical device for treating dysphagia, a swallowing disorder often resulting from stroke or brain injury. The device, Phagenyx, uses neurostimulation therapy to harness the brain's capacity for relearning lost functions via neuroplasticity. It consists of a base station and a catheter inserted through the nose, delivering optimal stimulations to the pharynx while recording patient data.

Adsilico is a medical technology company that specializes in developing advanced computer simulations to assess the safety and performance of medical devices. By using virtual patients, the company helps clients identify potential issues early in the development process, expedite time to market, and reduce the costs associated with traditional clinical trials.

Pragmatic specializes in ultra-low-cost flexible electronics. Its FlexICs, thinner than human hair, enable innovative solutions by embedding circuits invisibly into objects. The company offers a FlexIC Foundry service for custom application-specific devices and standard FlexIC products for mass market use cases like RFID and NFC. Pragmatic's revolutionary FlexLogIC production system facilitates high-volume manufacturing at significantly lower costs compared to traditional silicon IC fabs. Headquartered in Cambridge, UK, with a billion-unit production facility in Sedgefield, the company serves diverse markets such as consumer goods, retail, healthcare, and gaming.

Floreon is a company that specializes in developing a plant-based bioplastic designed as a sustainable alternative to traditional oil-based plastics. The company's innovative material is created by enhancing standard polylactic acid (PLA) with a specially formulated compound, resulting in a fully compostable and high-performing bioplastic. This unique formulation emerged from a commitment to create a greener and safer plastic solution, addressing the limitations of existing options in the market. After four years of development, including a collaboration with the University of Sheffield, Floreon has produced a tough bioplastic that not only competes with conventional plastics in performance but also significantly reduces carbon emissions, aligning with clients' sustainability objectives.

Pencil Biosciences is focused on advancing gene-editing technology through the development of a novel, programmable genome-modulation platform. This innovative approach seeks to address the limitations of existing gene-editing technologies, providing new therapeutic options for patients with rare diseases. By enhancing the precision and efficacy of genome modulation, Pencil Biosciences aims to facilitate a wide range of applications in the medical field, ultimately supporting healthcare professionals in overcoming the challenges associated with traditional gene-editing methods.

C-Capture Limited designs and develops solvent systems that capture carbon dioxide from flue gases and other emission sources. The company’s proprietary technology enables reversible, non‑toxic removal of CO2 in post‑combustion capture processes, making power generation and hard‑to‑abate industries more environmentally friendly and cost‑effective. Founded in 2008, the firm is headquartered in Leeds, United Kingdom.

Mimetrik is a developing solution to real-world healthcare problems that are now unsolved or inadequately addressed.

AssetCool is a thermal metaphotonics company that develops photonic coatings and materials to improve electrical network performance. Its products lower overhead line temperatures, increase conductor ampacity, and reduce carbon emissions, enabling higher capacity on existing lines while cutting energy losses, operating costs, and environmental impact.

Optalysys develops optical AI systems that accelerate deep learning tasks at groundbreaking speeds and with significantly reduced energy consumption compared to traditional computing hardware. Their embeddable technology enables supercomputing capability on edge and mobile devices.

LC AuxeTec is a materials company based on synthetic auxetic materials that enables resistance to high impact applications.

Recourse is a experiential skills development platform allows clinicians to immediately put theory into practice by simulating complex interactions with conversational digital humans. It support healthcare & life science organizations to achieve optimal performance.

Founded in 2015, Slingshot Simulations operates a Simulation-as-a-Service platform. It enables rapid simulation of complex large-scale systems and offers tools for automated configuration, deployment, management, and analysis.

QV Bioelectronics develops an innovative electric field therapy implant, GRACE, designed to extend the lives of brain tumor patients while maintaining their quality of life. This first-of-its-kind device targets glioblastoma, a cancer with poor outcomes, by slowing tumor growth and sparing healthy tissue.

Phlux Technology is a photonics company that specializes in the development of advanced infrared sensing technology. Established in September 2020 as a spin-out from the University of Sheffield, Phlux focuses on creating high-performance infrared sensors designed for applications in LIDAR, fiber sensing, and imaging systems. The company aims to provide affordable infrared sensors that bridge the performance gap between InGaAs single-photon avalanche diodes (SPADs) and conventional InGaAs avalanche photodiodes (APDs). By enhancing the capabilities of laser rangefinders and other sensor systems, Phlux Technology enables clients to expand the operational limits of eye-safe sensor applications.

Imperagen is a biotechnology company focused on enzyme engineering, artificial intelligence, and synthetic biology. It develops a life science platform that integrates patented advances in enzyme simulation, AI, synthetic biology, and automation to create novel enzyme products for manufacturing complex drug molecules. Its applications span laboratory tools, enzyme replacement therapies, and drug delivery systems, helping healthcare sectors address speed, capacity, and scalability challenges.

Opteran reverse-engineers biological brains to create neuromorphic software for autonomous machines. Harnessing evolutionary principles, Opteran provides robust, low-cost autonomy on the edge without requiring AI, data centers, or training.