OSF Ventures

Hellocare operates a comprehensive virtual healthcare platform that integrates software, hardware, and AI. This platform bridges the gap between healthcare providers and patients by offering features such as home care services, remote monitoring, telemedicine carts, alerting systems, and more. These solutions aim to improve patient satisfaction while reducing response times.

410 Medical is a healthcare technology company based in Durham, North Carolina, founded in 2013. The company has developed an innovative rapid infuser device designed to facilitate the swift delivery of fluids to critically ill patients in need of volume resuscitation. This device enhances the speed and efficiency of fluid administration, significantly improving care for patients suffering from life-threatening conditions such as sepsis and shock. By enabling a single healthcare provider to quickly set up and deliver vital fluids, the solution minimizes provider fatigue and allows for simultaneous attention to other patient care needs. It is particularly beneficial in pre-hospital settings and emergency departments, where rapid response is essential and resources may be limited.

Cala Health is a bioelectronic medicine company that develops wearable neuromodulation therapies for chronic diseases. Its primary product, Cala Trio therapy, is a non-invasive prescription treatment for essential tremor.

TailorMed Medical Ltd., established in 2017 and based in Tel Aviv, Israel, specializes in health IT solutions. The company develops and provides financial navigation technology and systems, designed to streamline and automate financial processes for both patients and healthcare providers. Their offerings include TailorMed Financial Navigation, a platform to manage and automate financial processes; TailorMed Financial Insights, an analytics and reporting dashboard to track and measure key performance indicators; and TailorMed Pharmacy, a platform to simplify drug ordering, tracking, and billing based on patient treatment regimens.

ShiraTronics develops neuromodulation therapies to treat chronic migraine by delivering continuous stimulation to targeted nerves to relieve, interrupt, and prevent migraine episodes. Founded in 2018 and based in Ireland, the company maintains an additional location in Minneapolis, Minnesota, and pursues innovative neuromodulation technology to address unmet neurological needs and improve patient outcomes.

Inflammatix develops rapid molecular diagnostics tests that interpret the immune system to resolve major clinical challenges. Initially focused on acute bacterial and viral infections, sepsis, and other conditions like tropical infections and autoimmune diseases.

Pieces Technologies, Inc. is a healthcare software solutions company founded in 2015 and headquartered in Dallas, Texas. The company emerged from the work of its founder, Ruben Amarasingham, MD, at Parkland Health & Hospital System, where he developed predictive models aimed at reducing patient readmissions. This initiative led to the establishment of the non-profit research institute PCCI, which has garnered over $50 million in scientific funding. Pieces Technologies functions as a dynamic center for innovation, addressing healthcare challenges for organizations worldwide by leveraging advanced predictive analytics and technology.

Huddle Up is a pediatric digital health company dedicated to supporting the growth, development, and mental health of children. Founded in 2015 and based in Madison, Wisconsin, Huddle Up transforms the care experience by emphasizing peer-to-peer interactions and specialty support. The company partners with school districts to promote academic performance and facilitate social-emotional development, while also focusing on community, equity, inclusion, and belonging. Through its personalized, outcome-driven approach, Huddle Up aims to enhance the well-being of children and adolescents, fostering healthier lives.

410 Medical is a healthcare technology company based in Durham, North Carolina, founded in 2013. The company has developed an innovative rapid infuser device designed to facilitate the swift delivery of fluids to critically ill patients in need of volume resuscitation. This device enhances the speed and efficiency of fluid administration, significantly improving care for patients suffering from life-threatening conditions such as sepsis and shock. By enabling a single healthcare provider to quickly set up and deliver vital fluids, the solution minimizes provider fatigue and allows for simultaneous attention to other patient care needs. It is particularly beneficial in pre-hospital settings and emergency departments, where rapid response is essential and resources may be limited.

Array Behavioral Care is a telepsychiatry service provider dedicated to enhancing access to quality behavioral health care through innovative technology applications. Established in 1999 by Geoffrey Boyce in New Jersey, the company offers a range of services including assessment, screening, diagnosis, consultations, and medication management. These services are delivered across various settings, from hospitals to homes, through divisions such as OnDemand Care, Scheduled Care, and AtHome Care. Array Behavioral Care aims to make mental health services convenient, affordable, and readily accessible for patients.

Cardiosense is a company that focuses on developing a physiological waveform AI platform aimed at creating predictive biomarkers for disease detection and treatment. By mining raw biosignals, Cardiosense provides enhanced visibility into cardiac functions and employs advanced signal processing techniques to identify pre-symptomatic markers of cardiac disease. The company specializes in utilizing non-invasive sensors and proprietary algorithms, which allow healthcare professionals to monitor and analyze cardiac health signals effectively. This innovative approach enables the early detection of diseases, thereby facilitating improved patient care and health tracking.

410 Medical is a healthcare technology company based in Durham, North Carolina, founded in 2013. The company has developed an innovative rapid infuser device designed to facilitate the swift delivery of fluids to critically ill patients in need of volume resuscitation. This device enhances the speed and efficiency of fluid administration, significantly improving care for patients suffering from life-threatening conditions such as sepsis and shock. By enabling a single healthcare provider to quickly set up and deliver vital fluids, the solution minimizes provider fatigue and allows for simultaneous attention to other patient care needs. It is particularly beneficial in pre-hospital settings and emergency departments, where rapid response is essential and resources may be limited.

Digital Diagnostics is a pioneering company developing artificial intelligence-based diagnostic systems for medical images. It offers solutions such as IDx-DR for diabetic retinopathy, IDx-G for glaucoma indicators, and IDx-AMD for age-related macular degeneration detection. The company's autonomous AI platform aims to improve healthcare accessibility, equity, and affordability by making clinical decisions without human intervention.

Founded in 2017, Socially Determined develops a risk intelligence platform focused on social determinants of health. Its core product, SocialScape, helps organizations understand and address social risks by providing actionable insights derived from various data sources. This solution is used by health plans, providers, life science companies, and government agencies to improve health outcomes and reduce costs.

CancerIQ is a precision health technology company focused on empowering healthcare providers to identify and manage patients at high risk for cancer. Its platform offers a comprehensive suite of tools, including predictive analytics and screening resources, to help clinicians accurately stratify patient risk and guide them toward appropriate genetic testing, screening, or treatment options. The platform features a robust content library of evidence-based guidelines and risk models, facilitating informed decision-making. Additionally, CancerIQ provides digital tools for genetic test ordering and patient management, aimed at enhancing patient education and engagement. By streamlining these processes, the company enables healthcare providers to improve patient outcomes and reduce the overall cost of care through early cancer detection.

Epitel is a digital health company developing a wearable, wireless EEG monitoring platform that enables accessible, reliable seizure detection. The system combines a cloud-based wearable sensor network with artificial intelligence to identify electrographic seizures, providing brain health insights for physicians, caregivers, and patients with neurological disorders to improve quality of life and care.

TailorMed Medical Ltd., established in 2017 and based in Tel Aviv, Israel, specializes in health IT solutions. The company develops and provides financial navigation technology and systems, designed to streamline and automate financial processes for both patients and healthcare providers. Their offerings include TailorMed Financial Navigation, a platform to manage and automate financial processes; TailorMed Financial Insights, an analytics and reporting dashboard to track and measure key performance indicators; and TailorMed Pharmacy, a platform to simplify drug ordering, tracking, and billing based on patient treatment regimens.

Huddle Up is a pediatric digital health company dedicated to supporting the growth, development, and mental health of children. Founded in 2015 and based in Madison, Wisconsin, Huddle Up transforms the care experience by emphasizing peer-to-peer interactions and specialty support. The company partners with school districts to promote academic performance and facilitate social-emotional development, while also focusing on community, equity, inclusion, and belonging. Through its personalized, outcome-driven approach, Huddle Up aims to enhance the well-being of children and adolescents, fostering healthier lives.

Exela Pharma Sciences, LLC is a rapidly growing US-based specialty pharmaceutical company focused on the development, manufacturing, and marketing of proprietary and generic sterile injectable products. The company aims to improve patient outcomes while reducing overall healthcare costs by offering a range of products, including generic injectables, ophthalmic, and inhalation medications. With a commitment to alleviating drug shortages, Exela is recognized for its dedication to enhancing the supply chain and creating high-value employment opportunities in rural areas. By providing therapeutically effective formulations, Exela increases treatment options for healthcare providers and enhances the quality of life and treatment experience for patients.

Current Health Limited is a healthcare technology company based in Edinburgh, United Kingdom, that specializes in wearable devices for monitoring patient vitals. Founded in 2014 and originally known as Snap40 Limited, the company rebranded in December 2018. Current Health's devices are designed to measure critical health indicators such as oxygen saturation, respiration rate, pulse rate, temperature, motion, activity, and posture, enabling early identification of potential health issues. Their patient monitoring platform facilitates the management of patients at home by collecting and analyzing data to detect and predict health deterioration. This allows patients to share daily activities, report symptoms, and complete structured questionnaires, ultimately helping healthcare providers reduce risks and costs associated with patient care.

Renovia Inc., founded in 2016 and based in Boston, Massachusetts, was a healthcare company focused on developing prescription digital therapeutics for pelvic floor disorders. The company's innovative device provided a clinically validated treatment for conditions such as stress, mixed, and urgent urinary incontinence, including overactive bladder. This technology allowed for real-time visualization of pelvic movement during muscle training sessions, facilitating a non-surgical and drug-free approach to treatment. However, Renovia ceased operations in late 2022 following a strategic review by its investors, and in January 2023, the majority of its assets, including intellectual property, were acquired by Axena Health, Inc.

Recuro Health is a developer of an integrated digital health platform that aims to transform the U.S. healthcare system from a reactive, disease-focused model to one centered on population health and outcomes. The company provides a tailored Digital Medical Home that caters to specific healthcare needs, offering essential virtual care services, including primary care, behavioral health, and urgent care. By equipping employers, providers, and managed care organizations with various digital tools, education, and guidance, Recuro Health enables patients to actively engage in their healthcare through health assessments and interactive communication with professionals, whether via messaging or video. This approach seeks to enhance patient involvement and improve health outcomes across diverse settings.

Inflammatix develops rapid molecular diagnostics tests that interpret the immune system to resolve major clinical challenges. Initially focused on acute bacterial and viral infections, sepsis, and other conditions like tropical infections and autoimmune diseases.

Huddle Up is a pediatric digital health company dedicated to supporting the growth, development, and mental health of children. Founded in 2015 and based in Madison, Wisconsin, Huddle Up transforms the care experience by emphasizing peer-to-peer interactions and specialty support. The company partners with school districts to promote academic performance and facilitate social-emotional development, while also focusing on community, equity, inclusion, and belonging. Through its personalized, outcome-driven approach, Huddle Up aims to enhance the well-being of children and adolescents, fostering healthier lives.

PhotoniCare is a medical device company that develops ear-diagnosis devices using light-based technology to see through the eardrum into the middle ear, enabling clinicians to visualize the contents and determine whether antibiotics or surgical interventions are needed. Its flagship device, TOMi Scope, uses near-infrared light to provide views beyond the eardrum and support assessment through optical coherence imaging. The company's imaging platform aims to extend its applications beyond otology and improve clinical decision-making in middle-ear infections. PhotoniCare was founded in 2013 and is based in Champaign, Illinois.

VIDA is a health technology company delivering AI-enabled imaging and data intelligence to improve respiratory care and accelerate drug development. Its platform supports clinicians in managing patients with chronic lung conditions such as COPD, interstitial lung disease, and lung cancer, as well as responses to emerging respiratory diseases. By combining quantitative data analytics with visualizations, VIDA helps improve care coordination, patient outcomes, and operational efficiency. The company also provides imaging services and integrated clinical data to support pharmaceutical research, enabling faster study enrollment, more precise biomarker targeting, and improved trial outcomes. VIDA’s software has regulatory clearances for clinical use in key markets, including FDA clearance, CE marking, Health Canada licensing, and TGA registration across the US, EU, Canada, and Australia. The business aims to bridge clinical care and life sciences by offering software that supports both patient management and research activities.

SilverCloud Health, established in 2011, is a digital health company that develops and provides online therapeutic solutions via tailored clinical programs. Headquartered in Boston, Massachusetts, with offices in Dublin, Ireland, and London, UK, the company's SilverCloud platform offers evidence-based, supported digital therapies to various healthcare sectors. It aims to increase client/patient engagement and reduce program dropout rates, as demonstrated by a three-fold improvement in these metrics compared to leading online therapeutic products.

CareSignal is a remote patient monitoring platform designed to enhance the performance of payers and providers in value-based care by focusing on patient engagement and early risk identification. The platform utilizes device-less technology to reach large patient populations through disease-specific, evidence-based automated communications, including text messages and phone calls. It enables care teams to receive real-time alerts that facilitate timely prioritization and proactive outreach. CareSignal is particularly committed to supporting underserved populations and safety-net providers, ensuring that patients can interact with the system using their existing phones. This approach helps care teams address chronic, behavioral, and social challenges faced by patients, promoting better health outcomes.

Health Scholars is a developer of medical simulation training software and virtual reality training solutions for healthcare providers and their staff. The platform combines clinical education, analytics, and VR technology to deliver scalable training across health systems. Its offerings include pre-hospital ACLS VR training for first responders, in hospital ACLS VR training for clinicians, and The OR, a VR surgical fire training module designed to mitigate risks and liability. The software is designed to manage, deliver, and track interactive training content, enabling cost-effective, immersive learning and improved preparedness across clinical teams.

Pieces Technologies, Inc. is a healthcare software solutions company founded in 2015 and headquartered in Dallas, Texas. The company emerged from the work of its founder, Ruben Amarasingham, MD, at Parkland Health & Hospital System, where he developed predictive models aimed at reducing patient readmissions. This initiative led to the establishment of the non-profit research institute PCCI, which has garnered over $50 million in scientific funding. Pieces Technologies functions as a dynamic center for innovation, addressing healthcare challenges for organizations worldwide by leveraging advanced predictive analytics and technology.

Founded in 2017, Socially Determined develops a risk intelligence platform focused on social determinants of health. Its core product, SocialScape, helps organizations understand and address social risks by providing actionable insights derived from various data sources. This solution is used by health plans, providers, life science companies, and government agencies to improve health outcomes and reduce costs.

410 Medical is a healthcare technology company based in Durham, North Carolina, founded in 2013. The company has developed an innovative rapid infuser device designed to facilitate the swift delivery of fluids to critically ill patients in need of volume resuscitation. This device enhances the speed and efficiency of fluid administration, significantly improving care for patients suffering from life-threatening conditions such as sepsis and shock. By enabling a single healthcare provider to quickly set up and deliver vital fluids, the solution minimizes provider fatigue and allows for simultaneous attention to other patient care needs. It is particularly beneficial in pre-hospital settings and emergency departments, where rapid response is essential and resources may be limited.

InsightRX is a software platform that applies quantitative pharmacology and machine learning to deliver individualized understanding of a patient’s response to treatment. The system provides point-of-care clinical decision support tools to guide dosing decisions at both the patient and population levels. It leverages clinically validated pharmacokinetic models, patient physiology, pharmacogenomics, drug concentrations, and biomarkers to optimize dosing, combining real-time patient data with machine learning to inform dose optimization. The platform also uses disease-based pharmacodynamics models to inform treatment decisions. InsightRX launched in 2015 and is based in San Francisco, California.

Exo is a medical device startup specializing in handheld ultrasound technology. It combines advanced materials, sensors, signal processing, and computation with semiconductor manufacturing economies to deliver affordable, high-quality imaging. This empowers healthcare professionals to make critical real-time decisions, enhancing patient outcomes.

Paradigm Diagnostics specializes in advanced diagnostics technology for personalized cancer treatment. Using Next-Gen Sequencing and other biomarker analysis methods, the company provides detailed information about a patient's genomic and proteomic landscape, identifying specific characteristics of their tumor. This data is used to tailor treatment plans by matching potential therapies to the unique profile of each patient's cancer, thereby enhancing the effectiveness of clinical trials and improving outcomes for cancer patients.

Gauss Surgical, Inc. is a medical technology company that specializes in real-time blood monitoring solutions to enhance patient outcomes in surgical and obstetric settings. Founded in 2011 and headquartered in Los Altos, California, Gauss Surgical develops the Triton system, which includes various models suited for different medical needs. Triton assists healthcare professionals in monitoring and estimating blood loss during procedures, allowing for timely intervention in cases of hemorrhage. The system offers objective metrics for blood loss, thereby facilitating better clinical decision-making regarding transfusions. Serving the healthcare sector primarily in the United States, Gauss Surgical's products are designed to integrate seamlessly into existing medical practices, using sophisticated algorithms and HIPAA-compliant technology to deliver accurate monitoring in real time.

Endotronix develops and manufactures implantable wireless pulmonary artery pressure sensors for early detection of worsening heart failure. The company's platform includes a cloud-based disease management data system, enabling remote patient monitoring.

Renovia Inc., founded in 2016 and based in Boston, Massachusetts, was a healthcare company focused on developing prescription digital therapeutics for pelvic floor disorders. The company's innovative device provided a clinically validated treatment for conditions such as stress, mixed, and urgent urinary incontinence, including overactive bladder. This technology allowed for real-time visualization of pelvic movement during muscle training sessions, facilitating a non-surgical and drug-free approach to treatment. However, Renovia ceased operations in late 2022 following a strategic review by its investors, and in January 2023, the majority of its assets, including intellectual property, were acquired by Axena Health, Inc.

Regroup is a provider of integrated telepsychiatry services that facilitates remote psychiatric care through live and interactive video conferencing. The company aims to enhance access to mental health care, allowing patients to overcome barriers such as geographical distances, mobility restrictions, and the time and cost associated with in-person visits. Regroup's services prioritize patient privacy by employing end-to-end encryption to ensure the confidentiality of personal health information. By leveraging technology, Regroup addresses the growing need for accessible mental health resources in a convenient and secure manner.

Level Ex, Inc. is a Chicago-based company that specializes in developing virtual surgery mobile applications and professional medical video games aimed at physicians. Founded in 2015, the company focuses on enhancing surgical training through innovative platforms, such as Virtual Technique Guides, which leverage multiplayer interactivity to facilitate virtual procedures in collaboration with medical device representatives. One of its notable products, Airway EX, is designed to help physicians master critical skills in endoscopic and interventional airway procedures, addressing various medical challenges such as obstructing tumors and complex intubations. By employing advanced video game technology and cognitive neuroscience, Level Ex enables healthcare professionals to stay current with rare cases, new medical devices, and evolving drug therapies, ultimately improving their surgical capabilities and decision-making skills.

PatientWisdom LLC, established in 2015 and headquartered in New Haven, Connecticut, operates a digital health platform that collects, curates, segments, and shares patient stories to enhance healthcare experiences and delivery. The platform offers three primary solutions: PatientWisdom facilitates understanding of patients' needs before clinical encounters; ProviderWisdom gathers insights from clinicians and staff to improve care responsiveness; CommunityWisdom provides a comprehensive view of communities for health organizations to develop or partner with programs. Serving patients, families, healthcare providers, researchers, educators, manufacturers, and payers, PatientWisdom aims to transform care by listening to stakeholders individually and at scale.

Regroup is a provider of integrated telepsychiatry services that facilitates remote psychiatric care through live and interactive video conferencing. The company aims to enhance access to mental health care, allowing patients to overcome barriers such as geographical distances, mobility restrictions, and the time and cost associated with in-person visits. Regroup's services prioritize patient privacy by employing end-to-end encryption to ensure the confidentiality of personal health information. By leveraging technology, Regroup addresses the growing need for accessible mental health resources in a convenient and secure manner.

InsightRX is a software platform that applies quantitative pharmacology and machine learning to deliver individualized understanding of a patient’s response to treatment. The system provides point-of-care clinical decision support tools to guide dosing decisions at both the patient and population levels. It leverages clinically validated pharmacokinetic models, patient physiology, pharmacogenomics, drug concentrations, and biomarkers to optimize dosing, combining real-time patient data with machine learning to inform dose optimization. The platform also uses disease-based pharmacodynamics models to inform treatment decisions. InsightRX launched in 2015 and is based in San Francisco, California.

AVIA Inc. is a digital transformation partner for healthcare organizations, founded in 2012 and based in Chicago, Illinois. The company specializes in developing a knowledge-sharing and collaboration platform that offers market intelligence, collaborative tools, and results-based consulting services. AVIA aims to address the strategic challenges faced by healthcare providers by facilitating access to a network of health systems and strategic partners. Their platform allows healthcare leaders to research, evaluate, and select digital health solutions, while also engaging with expert consultants to guide them through the digital transformation process. This comprehensive approach enables healthcare enterprises to innovate and achieve digital success effectively.

Endotronix develops and manufactures implantable wireless pulmonary artery pressure sensors for early detection of worsening heart failure. The company's platform includes a cloud-based disease management data system, enabling remote patient monitoring.

BrightWater Medical is a medical device company based in Mountain View, California, founded by Dr. Bob Smouse in 2014. The company specializes in developing innovative devices for interventional radiologists, with a focus on treating ureteral blockages. Its flagship product, the ConvertX Stent, can be converted from a catheter to a nephroureteral stent during a single procedure, eliminating the need for a second invasive intervention. This technology aims to simplify patient treatment and increase efficiency for healthcare providers. BrightWater Medical operates as a subsidiary of Merit Medical Systems.

Pieces Technologies, Inc. is a healthcare software solutions company founded in 2015 and headquartered in Dallas, Texas. The company emerged from the work of its founder, Ruben Amarasingham, MD, at Parkland Health & Hospital System, where he developed predictive models aimed at reducing patient readmissions. This initiative led to the establishment of the non-profit research institute PCCI, which has garnered over $50 million in scientific funding. Pieces Technologies functions as a dynamic center for innovation, addressing healthcare challenges for organizations worldwide by leveraging advanced predictive analytics and technology.

Health Catalyst is a technology company that specializes in data and analytics solutions for healthcare organizations. The company offers a platform that organizes, normalizes, and links health-related data from various systems, making it accessible and searchable for all users, including those without technical expertise. Health Catalyst operates through two main segments: the Technology segment, which generates the majority of its revenue through cloud-based subscriptions, time-based licenses, and maintenance fees for its data platforms and analytics applications; and the Professional Services segment, which provides a range of services including analytics, implementation, strategic advisory, and outsourcing to help clients optimize their use of the technology. By integrating and analyzing healthcare data, Health Catalyst aims to enhance decision-making and improve outcomes in the healthcare sector.

Euphrates Vascular is a medical technology company based in St. Louis, Missouri, that focuses on innovative solutions for the treatment of stroke, heart disease, and other conditions. The company has developed a proprietary magnetically-enhanced diffusion (MED) system that utilizes magnet-based technology to dissolve blood clots more rapidly than existing treatment options. This system aims to improve the efficacy of FDA-approved clot-busting medications, potentially reducing mortality rates associated with stroke and cardiovascular diseases. In addition to the MED system, Euphrates Vascular offers MED MicroBeads, which are designed to deliver therapeutic agents directly to clots during thrombolysis therapy, and a touch screen-operated MED Workstation. Founded by physicists with extensive experience in medical technology, the company continues to advance its pioneering approaches in the healthcare sector, attracting interest from investors and media alike.