Capital Midwest Fund is a venture capital firm based in Mequon, Wisconsin, that backs early-stage companies in the Midwest across sectors such as advanced manufacturing, life sciences, healthcare, B2B and business services, software and SaaS, information technology and IoT, and energy. The firm concentrates on Midwest investments, with Wisconsin as a primary focus, and targets initial investments typically in the low to mid single-digit millions per company. It also pursues ESG and diversity-inclusion related investments as part of its strategy.

HealthX Ventures is a Madison, Wisconsin-based venture capital firm founded in 2015 that focuses on the digital healthcare sector. It funds early-stage digital health companies that develop software and technology-enabled solutions to improve safety, efficiency, and affordability in healthcare, with an emphasis on scalable, user-friendly products and business models.

Venture Investors is a Wisconsin-based venture capital firm that concentrates on seed and early-stage investments in healthcare, life sciences, diagnostics, therapeutics, medical devices, digital health, and related technology sectors. Headquartered in Madison with offices in Ann Arbor and Milwaukee, it seeks opportunities linked to university technology transfer and licenses from research institutions, particularly in the Midwest. The firm typically makes seed investments ranging from approximately 0.25 million to 2.5 million and can lead or co-invest, often investing in preferred stock and/or debt with warrant coverage. It targets companies with meaningful market potential and a constructive path to exit within five to seven years, through an initial public offering or strategic sale. While rooted in the Midwest research ecosystem, Venture Investors also evaluates nationwide opportunities aligned with its healthcare and technology portfolio.

Golden Angels Investors is an angel investment group based in Brookfield, Wisconsin, founded in 2002. The organization makes investments in entrepreneurial ventures, with members who have a track record of business success and a commitment to helping entrepreneurs build strong companies. It leads opportunities directly and also participates in opportunities led by other investors. The group focuses on health tech, ed-tech, and B2B services, selecting early-stage ventures in these sectors and providing strategic guidance alongside capital.

Silicon Pastures is a Midwest-focused investment group of angel investors that funds technology-driven ventures and provides strategic guidance. Based in Milwaukee, Wisconsin, the network meets monthly to review business proposals and conduct due diligence, focusing on technology companies in the U.S. Midwest and beyond, and it aims to help portfolio firms scale and, when appropriate, expand internationally through the investors’ expertise and connections. The group has its roots in the Wisconsin technology scene and has been active since 2000.

TitletownTech is an early-stage venture capital firm based in Green Bay, Wisconsin, formed in 2019 through a partnership between the Green Bay Packers and Microsoft. It supports bold entrepreneurs solving meaningful problems by leveraging a collaborative ecosystem that includes investors, in-residence partners, industry advisors, higher education, and a dedicated team to provide tailored guidance. The firm invests across six verticals: sports, media and entertainment; digital health; agriculture, water and the environment; manufacturing and construction; supply chain and logistics; and cross-industry technology, with a focus on the United States and the Midwest. Its approach blends capital with hands-on support to help founders scale, and it operates within a network that connects startup teams with resources across its regional ecosystem.

WISC Partners is a venture capital firm based in Madison, Wisconsin, founded in 2013. The firm provides strategic operating capital to entrepreneurs with the potential to build scalable companies that solve meaningful customer problems. It invests in technology-enabled services, industrial technology, agricultural technology, and healthcare innovation, including healthcare technology systems and devices.

CSA Partners is a venture capital firm based in Milwaukee, Wisconsin, that funds early-stage, high-growth companies in the Midwest. Founded in 2013, it seeks startups with a clear vision and elegant solutions to well-defined problems, supporting entrepreneurs through a lean, data-driven, outcomes-oriented approach.

Rock River Capital Partners is a Madison, Wisconsin-based venture capital firm that concentrates on early-stage and growth investments in the Midwest. The firm targets companies across sectors that demonstrate initial product-market fit and potential for growth, with a preference for technical disruptors, particularly software-focused opportunities. It aims to be the lead investor, often taking a board seat to actively support portfolio companies, and plans for follow-on funding to back later rounds. The team seeks founder-aligned terms and collaborates with large Midwest venture financiers to help portfolio companies scale. While industry-agnostic, the firm emphasizes software and technology-enabled markets and seeks companies positioned for measurable growth.

Wisconsin Super Angel Fund is a Milwaukee-based venture capital group that invests in early-stage Wisconsin-based companies. It identifies, capitalizes and mentors startups and is industry agnostic, focusing on early exit opportunities. It typically invests between $0.25 million and $1 million in companies with pre-money valuations under $5 million and aims to exit within three to five years; it often takes two board seats on portfolio companies.

4490 Ventures is a Madison, Wisconsin-based technology-focused venture capital firm founded in 2014 that concentrates on early-stage investments in technology companies. The firm targets Series A and B rounds and focuses on companies located in the Midwest, with an emphasis on web3-enabled enterprise software, health technology, Internet of Things, and software-as-a-service sectors. Typical investment sizes range from $5 million to $8 million per company, supporting growth-oriented startups as they scale. The firm operates across the Midwest and maintains a broader geographic reach including the Midatlantic and West Coast regions.

Venture Management is a venture capital firm based in Madison, Wisconsin, founded in 1994, that focuses on seed-stage and startup investments in Wisconsin, targeting companies in the technology and healthcare sectors.

Robert W. Baird & Co. is an employee-owned financial services firm offering wealth management, capital markets, asset management and private equity services. Headquartered in Milwaukee, Wisconsin, it serves individual, institutional, corporate and municipal clients and operates through offices in the United States, Europe and Asia. The firm provides advisory services such as mergers and acquisitions, business valuations and transition planning for growth-oriented lower- and middle-market companies, and it maintains an affiliate that engages in private equity and venture investments to build world-class businesses.

Winnebago Seed Fund is a venture capital firm based in Neenah, Wisconsin, established around 2016–2017. It focuses on seed-stage technology startups in Wisconsin, with emphasis on the Fox Valley region. The firm seeks to back talented entrepreneurs to rapidly grow their businesses and generate investor returns through early-stage investments.

Idea Fund of La Crosse is a venture capital firm based in La Crosse, Wisconsin, founded in 2016. It seeks to invest in a broad range of sectors, including information technology, health information technology, data analytics, supply chain, agriculture, manufacturing, and financial services.

N29 Capital Partners is a venture capital firm founded in 2015 and based in Manitowish Waters, Wisconsin. It focuses on early-stage companies across software, information technology, web, SaaS, e-commerce and hardware sectors.

American Family Ventures is the corporate venture capital arm of American Family Insurance. Founded in 2010 and based in Madison, Wisconsin, it makes early-stage investments in startups—primarily seed to Series B—in technologies and business models relevant to the future of the insurance industry, including insurtech, FinTech, data analytics, IoT, and cybersecurity. It seeks minority equity positions and typically invests roughly $0.5 million to $2 million, with some rounds reported up to $5 million, and supports portfolio companies through its insurtech network and value-add programs to advance safety, efficiency and quality of life in insurance and related sectors.

Bascom Ventures is a community of accredited University of Wisconsin–Madison alumni who pool capital to invest in a venture capital fund that backs companies connected to the UW ecosystem. By aggregating member investments and networks, the group seeks to support UW-connected startups through early-stage venture opportunities and guidance from a UW-aligned investor community.

SymphonyAlpha Ventures is a Midwest-focused venture capital firm based in Madison, Wisconsin, investing in startup and early-stage healthcare IT and SaaS companies. It supports product development and market entry through a network of health systems and large enterprises, leveraging experience in healthcare technology to accelerate adoption and growth.

Inventure Capital is a boutique investment firm based in Madison, Wisconsin, focusing on early-stage investments in technology, biotech, and clean-tech startups in the Midwest, and maintaining a portfolio that includes real estate development projects such as multi-family apartment developments. The firm combines technology-oriented investments with real estate exposure and provides consulting and advisory services, including expert financial analysis and due diligence research on an ad hoc basis.

Calumet Venture Fund was a Madison, Wisconsin-based venture capital firm that invested in early-stage information technology companies, including software, software-as-a-service, and e-learning, in the Midwest.

Tundra Angels is an angel investor network and angel group based in Green Bay, Wisconsin. Founded in 2020, it invests in startups and helps founders win.

Foley Ventures is the investment arm of Foley & Lardner, a U.S. law firm, based in Boston with additional offices in Madison, Palo Alto and Tampa. The firm makes direct investments in start-ups and emerging companies and also participates in fund of funds, with a focus on technology and life sciences. Its portfolio interests span software, services, consumer, internet, media, healthcare, biotech, medical devices and related sectors. Foley Ventures typically invests alongside the firm’s clients and client funds, aligning capital with early-stage and growth opportunities. By leveraging the firm’s network across industries, it supports portfolio companies with strategic and operational resources. The approach centers on funding companies that have secured investment from venture funds or angel investors, aiming to complement investor ecosystems rather than operate as a standalone fund.

Arenberg Holdings is a Milwaukee, Wisconsin-based venture capital firm that invests in early-stage companies in the Midwest, with a particular emphasis on the manufacturing sector. The firm provides capital and strategic guidance to help startups establish operations in the region. In addition to venture activity, Arenberg Holdings pursues real estate development in socioeconomically challenged areas of Milwaukee, reflecting a broader commitment to regional economic development.

Alumni Ventures Group is a venture capital firm based in Manchester, New Hampshire, established in 2013. It targets individual accredited investors who previously had limited access to venture capital by enabling alumni from top entrepreneurial schools to invest together in ventures led by fellow alumni. The firm backs companies with an alumni connection and an institutional lead investor with sector expertise. It offers focused funds that provide accredited investors access to a diversified venture portfolio by type, sector, stage, and geography. The organization engages in seed, early-stage, and late-stage pre-IPO investments across technology, consumer, financial services, health care, life sciences, and other sectors.

Ben Franklin Technology Partners of Southeastern Pennsylvania is a non-profit organization founded in 1982 that supports the region's technology ecosystem. Based in Philadelphia, it acts as a capital provider and catalyst for early-stage and growing technology companies across information technology, health, and physical sciences by offering seed-stage funding and related resources to accelerate commercialization. The organization facilitates university–industry partnerships and regional initiatives that connect scientific research with market opportunities, with the aim of creating jobs and strengthening entrepreneurial communities in Southeastern Pennsylvania. Through its programs and partnerships, it supports adoption of new technologies and helps build a robust regional innovation ecosystem.

Stonehenge Capital is a national specialty finance and growth investment firm that provides long-term capital to privately held companies. Founded in 1999 by former Banc One Capital Markets principals, the firm has expertise in private equity, tax credit, and structured finance and manages multiple private equity and mezzanine funds with over $500 million in capital. It operates from offices in Alabama, Colorado, Florida, Louisiana, Missouri, New York, Ohio, Texas, and Wisconsin and focuses on funding growth in manufacturing, distribution, business services, and healthcare sectors.

VC 414 is an early-stage venture capital firm based in Milwaukee, Wisconsin, established in 2022. It focuses on funding early‑stage B2B and B2B2C startups across the United States, prioritizing ventures led by women and other undercapitalized founders.

Build Your Legacy Ventures is a Milwaukee-based venture capital firm founded in 2024 that backs early-stage startups across entertainment and media, sports, consumer products, and technology. It operates as the exclusive venture investment arm for NBA champion Giannis Antetokounmpo, seeking to leverage his brand and network to support portfolio companies. The firm also runs an incubation program that provides practical mentorship, operational assistance, and tailored growth plans, along with strategic connections important for scaling in competitive sectors.

CMFG Ventures is the corporate venture capital arm of CUNA Mutual Holding Company. Based in Madison, Wisconsin, it invests in fintech, insurtech, credit union technology, data analytics, mobile and online banking, consumer lending and related financial services and insurance sectors in the United States. It backs seed, startup, Series A and B, and other early to mid-stage rounds, typically making investments of about $1 million to $5 million through balance sheet investments, and maintains an office in New York. The firm supports companies that serve financial institutions, credit unions and consumers, aiming to advance financial inclusion and the adoption of technology in financial services.

WVV Capital is a venture capital firm established in 2018 and based in Milwaukee, Wisconsin. The firm focuses on early-stage investments, targeting transformative innovations across several sectors, including healthcare, manufacturing, building technology, fintech, and information technology. WVV Capital is a joint venture that collaborates with notable partners such as Advocate Health, Foxconn, Johnson Controls, and Northwestern Mutual. As a Registered Investment Adviser, the firm aims to foster advancements that can significantly impact these industries in the United States.

Character is a venture capital firm founded in 2021 by John Zeratsky, Jake Knapp and Eli Blee-Goldman. Based in Milwaukee, Wisconsin, the firm makes seed-stage investments across the United States, targeting sectors such as artificial intelligence, machine learning, enterprise software, industry, climate, healthcare and life sciences. It operates as a remote-native firm and typically backs seed rounds up to about $1 million. After investing, Character collaborates with founders using the sprint methodology developed at Google Ventures to help startups refine product-market fit and accelerate growth.

Founded in 2018, Winnow Fund is a venture capital investment firm headquartered in Madison, Wisconsin. It focuses on early-stage investments in Wisconsin-based companies and has a particular interest in opportunities arising on college and university campuses.

Revolution is a Washington, DC-based investment firm founded in 2005 by Steve Case that focuses on private equity and growth capital across sectors including technology, financial services, media and entertainment, health, and consumer products. The firm manages a family of funds, including Revolution Ventures for early-stage technology investments and Revolution Growth for growth-stage opportunities, and operates Rise of the Rest to discover and fund startups outside traditional hubs. With offices in Washington, DC and San Francisco, Revolution partners with entrepreneurs and regional ecosystem leaders to back scalable companies and broaden geographic opportunity for American startups, often pursuing substantial investments and collaborating with other top-tier investors.

Right Side Capital Management is a San Francisco-based venture capital firm founded in 2010 that invests in early-stage technology startups. It specializes in pre-seed and seed rounds for capital-efficient companies, with a focus on the United States and Canada and occasional activity in Western Europe, Israel, Australia, and New Zealand. The firm typically makes 75 to 100 investments per year, with round sizes from 50,000 to 500,000 and pre-money valuations ranging from 1,000,000 to 3,500,000. Portfolio companies are typically located outside the San Francisco Bay Area and New York City, and the firm aims to provide a clear yes or no on opportunities within about two weeks.

Advantage Capital Partners is a private equity and venture capital firm founded in 1992 and headquartered in New Orleans, Louisiana, with additional offices across the United States. The firm specializes in equity and debt investments, including growth equity, senior and subordinated debt, and mezzanine financing, with a focus on small businesses and underserved communities. It collaborates with state and federal economic programs to support local economic development and has financed companies in sectors such as manufacturing, technology, business services, energy, and agribusiness, including renewable and solar projects. The firm targets opportunities across growth stages and aims to create lasting economic impact by expanding opportunity in low-income areas through private investment and public-private partnerships.

Great Oaks Venture Capital is an early-stage venture capital firm based in New York, founded in 2005. The firm makes seed and Series A investments in tech-based startups across software, healthcare, financial services, marketplaces, and enterprise sectors.

MaSa Partners is a social impact venture that provides financial and human capital to early-stage, mission-driven companies solving today's problems. Founded in 2015, the firm invests patient capital in its portfolio and believes that social change and sustainable development can be achieved without sacrificing financial returns.

Sand Hill Angels is a Mountain View, California-based angel investor network in Silicon Valley founded in 2000. The group comprises around 60+ technology professionals who collaborate to form and grow startup companies by investing in private technology firms at early stages. Its members focus on technology sectors including clean technology, Internet, information sciences, and life sciences, with activity in areas such as semiconductors, enterprise software, storage, and communications, as well as medical devices, diagnostics, and bioinformatics. Sand Hill Angels typically invest in seed and Series A rounds, and occasionally later-stage bridges, often committing $300K to $500K at a pre-money valuation under $5 million. The network works openly with venture capital funds and other angel groups to support the Bay Area ecosystem.

Cleveland Avenue is a venture capital firm based in Chicago, established in 2015, that makes investments across seed-stage through growth-stage rounds in food and beverage companies, lifestyle consumer brands, AgTech, and technology.

Service Provider Capital is a Colorado-based venture capital firm founded in 2014 that funds seed-stage technology companies across domains such as artificial intelligence, machine learning, blockchain, cybersecurity, fintech, e-commerce, education technology, hardware, robotics, information technology, health tech, and cannabis. The firm also co-invests in Series A rounds led by institutional venture funds, providing capital and guidance to startups in the United States, including the Midwest and Southeast regions.

Greycroft is a venture capital firm based in New York and Los Angeles that concentrates on technology startups, with a focus on the Internet and mobile markets. The firm uses its extensive media and technology industry connections to help entrepreneurs gain visibility, build strategic relationships, bring products to market, and scale successful businesses. Since inception Greycroft has invested in more than 200 companies and manages over $1 billion in capital. Its investment scope spans consumer internet, fintech, healthcare, and enterprise software, reflecting a broad approach to funding early- and growth-stage ventures in technology sectors.

OSF HealthCare is a not-for-profit Catholic health care system based in Peoria, Illinois, serving Illinois and Michigan. Founded in 1877, it operates eight acute care facilities, two colleges of nursing, and a primary care network with over 600 physicians and advanced practice providers. The system owns OSF Saint Francis Inc. and OSF Home Care Services, and supports OSF Healthcare Foundation. It spans facilities in Illinois and Michigan, delivering comprehensive, integrated care to more than 2.5 million people. Guided by values such as justice, compassion, integrity, teamwork, employee well-being, stewardship and leadership, OSF HealthCare pursues compassionate care aligned with Catholic ethical principles.

Headline is a San Francisco based venture capital firm founded in 1998 that operates globally with a presence in seven cities and leads rounds across stages. It maintains a multi fund approach, with Early Stage funds across the US, Europe, Asia and Brazil and a Growth Fund based in San Francisco that backs companies from Series B onward, enabling it to identify local trends and back scale across geographies. The firm backs a broad range of sectors including consumer, media, financial services, healthcare, information technology, SaaS, cybersecurity, e commerce, artificial intelligence and digital health, and has a notable portfolio featuring Sonos, The RealReal, Creditas, Sorare, Pismo, AppFolio, GoPuff, Acorns, Farfetch, Segment, Bumble and Yeahka. Headline also runs an Asia arm, Headline Asia, based in Tokyo, investing in East, South and Southeast Asia across B2B, media, fintech, healthcare, IT, e commerce, AI and other sectors, with activity including a 2020 vintage Asia IV fund focused on the region. Headline positions itself as a global, founder friendly investor that seeks to partner with ambitious entrepreneurs to build lasting companies.

FJ Labs is a New York-based venture capital firm founded in 2015 by Fabrice Grinda. It is stage-agnostic and focuses on marketplaces and consumer-facing startups, making seed and Series A investments. Typical checks range from 50,000 to 5,000,000 dollars. The firm supports early-stage companies across sectors such as e-commerce, fintech, ad tech, mobile, and software-as-a-service, seeking opportunities with high growth potential in the United States and internationally. Its portfolio includes a mix of consumer brands and marketplace platforms, reflecting an emphasis on business models that connect buyers and sellers or enable direct consumer experiences. FJ Labs aims to back entrepreneurs building scalable, disruptively positioned products and services, often partnering with founders early in their development to help accelerate growth.

Hackers/Founders is a Silicon Valley–based accelerator and venture capital firm that supports technology startups from seed to growth stages, equips founders, helps build vibrant tech ecosystems, and shares Silicon Valley insights with the broader entrepreneurial community.

HPS Investment Partners is a global investment firm focused on non-investment grade credit across the capital structure. Founded in 2007 and headquartered in New York, it operates a worldwide network of offices. The firm originated as a unit of Highbridge Capital Management, a subsidiary of J.P. Morgan Asset Management, and was acquired by its principals in 2016 after Highbridge’s hedge fund strategies remained with J.P. Morgan. HPS manages a variety of strategies, including syndicated leveraged loans, high-yield bonds, privately negotiated senior secured debt, mezzanine, asset-based lending, and private equity, and serves clients across industries such as insurance, healthcare, media, retail, logistics, and marine.

Uncorrelated Ventures is a venture capital firm founded in 2019 by Salil Deshpande and headquartered in San Francisco, California. It backs early-stage companies focused on infrastructure software and seeks opportunities in related areas such as decentralized finance, cryptocurrency, blockchain, and fintech.

Refactor Capital is a Burlingame, California-based venture capital firm focusing on seed- and early-stage investments in hard technology, biotechnology, health, climate, and related sectors. The firm is led by Zal Bilimoria, a former partner at Andreessen Horowitz and a veteran product and engineering executive with experience at Google, Netflix, and LinkedIn, who typically leads seed rounds with checks in the 1–2 million range.

Sweat Equity Ventures is a San Francisco–based value accelerator and investor that provides time and expertise in exchange for equity. Its team comprises operators, entrepreneurs, and technologists with histories of building successful companies and launching products used by millions. Founded in 2018, the firm focuses on technology startups, offering hands-on guidance through focused sprints to accelerate product development, team execution, and market traction. By pairing practical mentorship with access to operational resources, Sweat Equity Ventures aims to help B2B and enterprise ventures scale rapidly and create substantial commercial value.