Plum Alley

Openwater is a medical technology startup founded in 2016 and based in San Francisco, California. The company specializes in developing advanced wearable devices that utilize novel optoelectronics to achieve MRI-like resolution for medical diagnostics and treatments. By employing LCDs with small pixels, Openwater's technology creates holographic images that reduce scattering, enabling physicians to visualize the inner workings of the body and brain at a cellular level. This innovation allows for precise diagnosis and targeted treatment of diseases by manipulating or destroying individual cells without damaging surrounding tissue. Openwater aims to revolutionize medical imaging and improve patient outcomes through its cutting-edge approach.

Gameto is a biotechnology company focused on advancing female reproductive health through innovative therapies. Recognizing the significant lack of treatment options in this underserved area, Gameto employs cutting-edge scientific techniques to develop solutions that enhance the quality of life for women. The company utilizes cellular engineering to create a platform that produces engineered ovarian and endometrial cell lines capable of mimicking the functions of natural cells, including hormone production and response. This platform underpins a portfolio of cellular therapeutics aimed at addressing various female reproductive diseases. Gameto's first initiative, Fertilo, targets improvements in in vitro fertilization (IVF) and egg freezing processes, striving to make them shorter, safer, and more effective. Additionally, the company is developing Deovo, an organoid model of the female reproductive system, and Ameno, a cell-based therapy designed to mitigate health issues related to primary ovarian insufficiency and menopause. Through these efforts, Gameto aims to transform the landscape of female reproductive health care.

Ketos, Inc., operating as Ketos7 Inc., specializes in providing innovative hardware and software analytics solutions for water management. Founded in 2015 and based in Milpitas, California, the company offers a vertically integrated water intelligence platform that includes industrial-grade hardware, an IoT communication framework, and a comprehensive software platform. Ketos focuses on real-time monitoring and analysis of water systems, enabling clients to measure and manage key water quality parameters such as pH, dissolved solids, hardness, turbidity, and salinity. Its technology is designed for a variety of applications, including agricultural, industrial, and municipal settings, and aims to enhance water efficiency and quality. By leveraging automated reporting and predictive analytics, Ketos provides actionable insights that help organizations address critical water management challenges effectively.

Juvena Therapeutics is a biopharmaceutical company developing protein-based therapies to promote tissue rejuvenation and repair in elderly individuals. Founded in 2017, the company focuses on treating age-related conditions such as sarcopenia, wound healing, and neural regeneration.

Gameto is a biotechnology company focused on advancing female reproductive health through innovative therapies. Recognizing the significant lack of treatment options in this underserved area, Gameto employs cutting-edge scientific techniques to develop solutions that enhance the quality of life for women. The company utilizes cellular engineering to create a platform that produces engineered ovarian and endometrial cell lines capable of mimicking the functions of natural cells, including hormone production and response. This platform underpins a portfolio of cellular therapeutics aimed at addressing various female reproductive diseases. Gameto's first initiative, Fertilo, targets improvements in in vitro fertilization (IVF) and egg freezing processes, striving to make them shorter, safer, and more effective. Additionally, the company is developing Deovo, an organoid model of the female reproductive system, and Ameno, a cell-based therapy designed to mitigate health issues related to primary ovarian insufficiency and menopause. Through these efforts, Gameto aims to transform the landscape of female reproductive health care.

AiFi Inc. is a technology company based in Santa Clara, California, that specializes in developing artificial intelligence-based software for cashier-free retail environments. Founded in 2016, AiFi's platform utilizes advanced computer vision and sensor networks to track shoppers as they navigate stores, manage their carts, and process transactions seamlessly. The technology is designed to be adaptable to a variety of store formats and can support operations in spaces up to 10,000 square feet without the need for shelf sensors. This flexibility allows retailers to implement autonomous shopping solutions that enhance customer experiences while providing valuable insights into inventory management and consumer behavior. AiFi partners with numerous global retailers, including ALDI South Group and Carrefour, to create customized shopping experiences that facilitate reliable, contactless operations. The company has established itself as a leader in the autonomous retail space, being recognized for having the highest number of computer vision-powered autonomous stores worldwide.

Gameto is a biotechnology company focused on advancing female reproductive health through innovative therapies. Recognizing the significant lack of treatment options in this underserved area, Gameto employs cutting-edge scientific techniques to develop solutions that enhance the quality of life for women. The company utilizes cellular engineering to create a platform that produces engineered ovarian and endometrial cell lines capable of mimicking the functions of natural cells, including hormone production and response. This platform underpins a portfolio of cellular therapeutics aimed at addressing various female reproductive diseases. Gameto's first initiative, Fertilo, targets improvements in in vitro fertilization (IVF) and egg freezing processes, striving to make them shorter, safer, and more effective. Additionally, the company is developing Deovo, an organoid model of the female reproductive system, and Ameno, a cell-based therapy designed to mitigate health issues related to primary ovarian insufficiency and menopause. Through these efforts, Gameto aims to transform the landscape of female reproductive health care.

Helaina is a biotechnology company dedicated to producing milk-equivalent baby formula designed as a breast milk alternative. By utilizing fermentation technology, Helaina creates bioactive proteins that replicate the functional proteins found in human breast milk, thereby offering a new category of functional food products. These products not only provide essential nutrients but also deliver immune benefits, positioning Helaina as a pioneer in the infant nutrition sector. The company's innovative approach aims to provide infants with nutritional options that closely resemble the composition and benefits of breast milk, addressing the needs of families seeking alternatives.

Mammoth Biosciences harnesses diverse CRISPR systems for various applications. It offers DETECTR™ for nucleic acid detection in diseases like cancer and infections, and CRISPR-Cas systems for therapeutic genome editing in immuno-oncology, autoimmune diseases, and liver disorders. Its solutions span healthcare, agriculture, environmental monitoring, biodefense, and other sectors.

Einride AB, established in 2016, specializes in sustainable freight transportation. Headquartered in Stockholm, Sweden, with additional offices in Gothenburg and Palo Alto, the company manufactures electric trucks, known as Einride Pods, for road freight. These vehicles are designed for autonomous operation, reducing emissions and enhancing safety. Einride also offers digital platforms for clients to plan, order, and track shipments, providing real-time data and insights. Notably, Einride became the first company to operate an autonomous, electric freight vehicle on a public road in 2019.

Bitwise Industries Inc. is a technology ecosystem company based in Fresno, California, focused on enhancing the local technology landscape. Established in 2013, the company operates Geekwise Academy, which provides accelerated coding education aimed at individuals of all ages, particularly from marginalized backgrounds. In addition to educational services, Bitwise Industries runs a custom software development firm, Shift3 Technologies, that connects experienced developers with entry-level programmers to create software solutions. The company also fosters community and collaboration by developing tech venues and co-working spaces that serve as hubs for technologists and technology companies. Through these initiatives, Bitwise Industries aims to empower individuals with vital tech skills and create pathways to meaningful careers in the technology sector.

Founded in 2015, Ashvattha Therapeutics develops precision therapeutics targeting actively endocytosing cells. Its pipeline focuses on neurology, oncology, and ophthalmology, aiming to treat diseases with improved efficacy and reduced side effects.

Air Protein is a Berkeley, California-based startup focused on developing sustainable protein derived from carbon dioxide in the air. The company employs a proprietary probiotic process to transform CO2 into protein-enriched food products, which can be used in various applications, including meat-free burgers, protein-enriched pasta, cereals, and beverages. By utilizing ordinary elements from the atmosphere, Air Protein produces its protein without hormones, pesticides, or herbicides, while also significantly reducing the land and water requirements compared to traditional meat production. This innovative approach allows meat lovers to enjoy sustainable food options that contribute to a more environmentally friendly future.

Founded in 2007, Aclima is a climate-tech company specializing in mapping and analyzing air pollution using advanced measurement platforms. It deploys large-scale sensor networks to collect real-time data, providing actionable insights for governments, businesses, and communities to protect public health and reduce emissions.

Ketos, Inc., operating as Ketos7 Inc., specializes in providing innovative hardware and software analytics solutions for water management. Founded in 2015 and based in Milpitas, California, the company offers a vertically integrated water intelligence platform that includes industrial-grade hardware, an IoT communication framework, and a comprehensive software platform. Ketos focuses on real-time monitoring and analysis of water systems, enabling clients to measure and manage key water quality parameters such as pH, dissolved solids, hardness, turbidity, and salinity. Its technology is designed for a variety of applications, including agricultural, industrial, and municipal settings, and aims to enhance water efficiency and quality. By leveraging automated reporting and predictive analytics, Ketos provides actionable insights that help organizations address critical water management challenges effectively.

AiFi Inc. is a technology company based in Santa Clara, California, that specializes in developing artificial intelligence-based software for cashier-free retail environments. Founded in 2016, AiFi's platform utilizes advanced computer vision and sensor networks to track shoppers as they navigate stores, manage their carts, and process transactions seamlessly. The technology is designed to be adaptable to a variety of store formats and can support operations in spaces up to 10,000 square feet without the need for shelf sensors. This flexibility allows retailers to implement autonomous shopping solutions that enhance customer experiences while providing valuable insights into inventory management and consumer behavior. AiFi partners with numerous global retailers, including ALDI South Group and Carrefour, to create customized shopping experiences that facilitate reliable, contactless operations. The company has established itself as a leader in the autonomous retail space, being recognized for having the highest number of computer vision-powered autonomous stores worldwide.

Founded in 2015, Ashvattha Therapeutics develops precision therapeutics targeting actively endocytosing cells. Its pipeline focuses on neurology, oncology, and ophthalmology, aiming to treat diseases with improved efficacy and reduced side effects.

Diligent Robotics develops hospital service robots and related AI software to assist clinical and nursing staff with logistical tasks, enabling more time for direct patient care. Its flagship robot, Moxi, operates in hospital environments to handle routine duties and collaborate with humans, supported by AI-based software that enables safe interaction and adaptation to human workflows. Founded in 2017 and based in Austin, Texas, the company seeks to improve patient satisfaction, quality of care, and safety by augmenting healthcare teams with robotic assistance.

Mammoth Biosciences harnesses diverse CRISPR systems for various applications. It offers DETECTR™ for nucleic acid detection in diseases like cancer and infections, and CRISPR-Cas systems for therapeutic genome editing in immuno-oncology, autoimmune diseases, and liver disorders. Its solutions span healthcare, agriculture, environmental monitoring, biodefense, and other sectors.

Einride AB, established in 2016, specializes in sustainable freight transportation. Headquartered in Stockholm, Sweden, with additional offices in Gothenburg and Palo Alto, the company manufactures electric trucks, known as Einride Pods, for road freight. These vehicles are designed for autonomous operation, reducing emissions and enhancing safety. Einride also offers digital platforms for clients to plan, order, and track shipments, providing real-time data and insights. Notably, Einride became the first company to operate an autonomous, electric freight vehicle on a public road in 2019.

Evrnu is a textile innovations company that specializes in producing engineered fibers from discarded clothing. By employing advanced regenerative fiber technologies, the company transforms textile waste into high-quality fiber sources. Its process involves breaking down cotton garment waste to the molecular level and reconstructing it into new, useful products. Evrnu's offerings include regenerative cellulosic and polyester fibers, as well as recoverable stretch materials, which provide significant environmental benefits. Through these innovations, Evrnu aims to create a circular ecosystem in the textile industry, promoting sustainability and reducing waste.

Node, recently acquired by SugarCRM, fuels Sugar's time-aware CX platform to help businesses by automatically forecasting expected outcomes and highlighting previously unforeseen challenges and opportunities. Extending Sugar’s time-aware CX platform, Node’s AI technology adds the most coveted element of time—the future. The combined solution offers wide-ranging capabilities for sales, marketing, and service teams. Node enables users of business applications to see into the future. Powered by Artificial Intuition™ technology, Node is the first turnkey AI-as-a-service platform focused on powering predictable business outcomes, which enterprises can use to quickly and seamlessly build advanced AI into both customer-facing and internal applications without investing years and millions of dollars on risky AI experiments. Applications powered by Node can deliver predictions that enable users to make smarter connections and decisions about how to engage with customers, employees, investors, and partners. Node was founded by Google's youngest employee, Falon Fatemi, and it's renowned technology team includes the Godfather of Search, Louis Monier who created Alta Vista, and Michael Radovancevich former CTO of Taleo and OpenX. Node is backed by Mark Cuban, NEA, Avalon Ventures, and JetBlue Technology Ventures.

BioEclipse Therapeutics is a clinical-stage oncology company developing immuno-oncology therapeutics using its proprietary technology. It aims to improve cancer patient outcomes by harnessing insights into the human immune system, pairing activated immune cells with adapted oncolytic viruses that selectively target and kill malignant cells.

Bitwise Industries Inc. is a technology ecosystem company based in Fresno, California, focused on enhancing the local technology landscape. Established in 2013, the company operates Geekwise Academy, which provides accelerated coding education aimed at individuals of all ages, particularly from marginalized backgrounds. In addition to educational services, Bitwise Industries runs a custom software development firm, Shift3 Technologies, that connects experienced developers with entry-level programmers to create software solutions. The company also fosters community and collaboration by developing tech venues and co-working spaces that serve as hubs for technologists and technology companies. Through these initiatives, Bitwise Industries aims to empower individuals with vital tech skills and create pathways to meaningful careers in the technology sector.

One Concern develops an AI-based platform that helps governments prepare for and respond to natural disasters. Its predictive analytics engine creates post-disaster damage maps, provides daily situational reports, and offers planning modules. The company focuses on earthquakes, hurricanes, floods, fires, and chronic stresses like poverty and climate change.

Markable Creators leverages AI-powered computer vision to enable social visual discovery shopping. It bridges the gap between social content and e-commerce by allowing viewers to shop clothing seen in videos across various platforms. The company offers a fully-automated solution, connecting with major global e-commerce platforms and live on prominent Asian social content platforms.

Ketos, Inc., operating as Ketos7 Inc., specializes in providing innovative hardware and software analytics solutions for water management. Founded in 2015 and based in Milpitas, California, the company offers a vertically integrated water intelligence platform that includes industrial-grade hardware, an IoT communication framework, and a comprehensive software platform. Ketos focuses on real-time monitoring and analysis of water systems, enabling clients to measure and manage key water quality parameters such as pH, dissolved solids, hardness, turbidity, and salinity. Its technology is designed for a variety of applications, including agricultural, industrial, and municipal settings, and aims to enhance water efficiency and quality. By leveraging automated reporting and predictive analytics, Ketos provides actionable insights that help organizations address critical water management challenges effectively.

Mammoth Biosciences harnesses diverse CRISPR systems for various applications. It offers DETECTR™ for nucleic acid detection in diseases like cancer and infections, and CRISPR-Cas systems for therapeutic genome editing in immuno-oncology, autoimmune diseases, and liver disorders. Its solutions span healthcare, agriculture, environmental monitoring, biodefense, and other sectors.

Founded in 2007, Aclima is a climate-tech company specializing in mapping and analyzing air pollution using advanced measurement platforms. It deploys large-scale sensor networks to collect real-time data, providing actionable insights for governments, businesses, and communities to protect public health and reduce emissions.

Shine is a developer of a self-care communication application designed to make well-being accessible. Their application is a messaging bot that gives out life advice and positive reinforcements including actionable tips based on confidence, daily happiness, mental health, productivity, and self-care audio challenges to grow on the go through sms texts on a daily basis, enabling people with anxiety and depression to get career and life advice to take proper care of themselves.

BioEclipse Therapeutics is a clinical-stage oncology company developing immuno-oncology therapeutics using its proprietary technology. It aims to improve cancer patient outcomes by harnessing insights into the human immune system, pairing activated immune cells with adapted oncolytic viruses that selectively target and kill malignant cells.

Vital Vio designs, engineers, and manufactures antimicrobial LED lighting systems under the VioSafe brand. Its products include antibacterial under-cabinet lights, T8 replacement bulbs, luminaires, downlight retrofit trims, white LEDs, and antibacterial LEDs for use in healthcare facilities, ambulatory surgery sites, laboratories, cleanrooms, food storage and preparation areas, public bathrooms, gyms, schools, offices, hospitality settings, and other environments. The company serves institutions such as Duke University, UCLA Health, Mount Sinai, St. Peters Health Partners, Case Western Reserve University, Nyserda, and others. Vital Vio’s lighting employs continuous visible-light disinfection that disrupts pathogen membranes to help reduce germs. The company serves healthcare, food processing, industrial, and commercial markets and offers a licensing model for consumer and residential products. Founded in 2012 and based in Troy, New York, Vital Vio focuses on products designed to support infection control in diverse environments.

Vow To Be Chic is an online platform specializing in the rental of designer bridesmaid dresses and Little White Dresses, providing an accessible solution for the bridesmaid experience. By offering services such as at-home try-on, shipping, dry cleaning, and insurance, the company alleviates the financial burden typically associated with being a bridesmaid, which averages around $1,700 when considering dress purchases and related expenses. This service also addresses the logistical challenges of coordinating dress selection and fittings for bridesmaids located across the country. Vow To Be Chic aims to enhance convenience and affordability in the wedding planning process, allowing bridesmaids to wear stylish dresses without the pressure of significant costs or time commitments.

ThinkCERCA is an educational technology company that offers a personalized literacy platform aimed at enhancing students' reading, writing, and critical thinking skills through argumentative writing. The platform enables educators to design, share, deliver, and assess lessons while tracking real-time progress in reading and writing. It fosters collaborative discussions and debates in classrooms, allowing students to engage with various subjects through the process of argumentation. With a presence in all 50 states and 130 countries, ThinkCERCA has partnered with notable education leaders and has received recognition for its innovative approach, including being a finalist for the SIAA CODiE Awards and being featured by The Atlantic and EdSurge. The company has also been acknowledged by Common Sense’s Graphite as one of the best tools in educational technology.

Tinkergarten, Inc. is a company that specializes in outdoor play-based learning classes for children aged 18 months to 8 years. Founded in 2014 and headquartered in Northampton, Massachusetts, Tinkergarten focuses on providing authentic early childhood education through engaging activities. The company connects families with local leaders who facilitate these activity-based classes, fostering skill development in a natural environment. By offering a network of community leaders, Tinkergarten enhances the learning experience, allowing children to grow in confidence and capability while enjoying the benefits of outdoor play.

Markable Creators leverages AI-powered computer vision to enable social visual discovery shopping. It bridges the gap between social content and e-commerce by allowing viewers to shop clothing seen in videos across various platforms. The company offers a fully-automated solution, connecting with major global e-commerce platforms and live on prominent Asian social content platforms.

Cordex Systems designs and manufactures a cardiovascular diagnostic device. Its product includes the Cordex EnDys System is a diagnostic tool that provides both early detection and ongoing monitoring of cardiovascular disease by measuring endothelial dysfunction.

EpiBone is a biotechnology company specializing in regenerative medicine for bone repair. It uses patient-specific stem cells and 3D fabrication to create living, anatomically precise bone grafts. The company's lead product has completed Phase I/IIa clinical trials, with additional products focusing on cartilage repair under development.

Tinkergarten, Inc. is a company that specializes in outdoor play-based learning classes for children aged 18 months to 8 years. Founded in 2014 and headquartered in Northampton, Massachusetts, Tinkergarten focuses on providing authentic early childhood education through engaging activities. The company connects families with local leaders who facilitate these activity-based classes, fostering skill development in a natural environment. By offering a network of community leaders, Tinkergarten enhances the learning experience, allowing children to grow in confidence and capability while enjoying the benefits of outdoor play.

Talent Sonar, following its merger with TalVista, focuses on assisting companies in managing unconscious bias to enhance diversity hiring practices. Through services such as redacted resume review, job description optimization, and structured interviews, Talent Sonar aims to help organizations create more inclusive and equitable recruitment processes. By leveraging technology and data-driven approaches, Talent Sonar aims to support companies in building diverse and talented teams.

Trustify, Inc. operates an on-demand technology platform that connects clients with licensed private investigators across the United States. Established in 2015 and headquartered in Arlington, Virginia, the company provides a range of services, including real-time observation, digital monitoring, background checks, and social media analysis. Trustify facilitates various investigative needs, such as locating witnesses, serving legal papers, asset recovery, and evidence collection for law enforcement. Additionally, it offers specialized support for insurance-related investigations, covering areas like workers' compensation, scene investigations, and liability assessments. By leveraging its network of professionals, Trustify aims to make truth, trust, and safety accessible to a broader audience.