Safeguard Scientifics

Safeguard Scientifics, Inc., established in 1953, is a growth capital firm headquartered in Radnor, Pennsylvania, with an additional office in Weston, Massachusetts. The company specializes in providing growth capital and operational support to technology companies operating within the healthcare, financial services, and digital media sectors. Safeguard typically invests between $5 million and $25 million in growth equity financing and between $5 million and $10 million in early-stage financing. It prefers to be the largest shareholder in its portfolio companies, usually taking a 20% to 50% stake, and often seeks a Board seat. The firm focuses on companies with proprietary technology and intellectual property, and it has a history of fostering innovation and building market leaders.

Mark A. Herndon

Senior Vice President and CFO

David Luk

Principal

Erik Rasmussen

Senior Vice President and Managing Director

Eric C. Salzman

CEO

Wei Zhang Ph.D

Principal and Healthcare Venture Capitalist

130 past transactions

Prognos Health

Venture Round in 2023
Prognos Health is a health tech company focused on healthcare analytics, offering a platform called prognosFACTOR. This innovative platform can quickly query billions of lab and health records from over 325 million de-identified patients, providing answers to clinically relevant healthcare questions in a fraction of the time traditionally required. Prognos Health allows clients to access HIPAA-compliant, patient-centric healthcare data through the Prognos Marketplace, facilitating a range of applications such as cohort design, patient journey studies, and health outcomes analysis. The company's clientele includes 25 of the top 30 pharmaceutical manufacturers and three of the top five health payers, highlighting its significant role in empowering precise decision-making throughout the healthcare landscape.

Syapse

Venture Round in 2022
Syapse, Inc. is a technology company that specializes in precision medicine through its innovative software platform, which aggregates and analyzes clinical, molecular, treatment, and outcomes data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse aims to enhance healthcare by providing actionable insights that support data-driven decision-making in precision oncology. The company operates the Syapse Learning Health Network, a global network that enables health systems and life sciences collaborators to share real-world cancer data. This network empowers healthcare organizations to collaborate effectively, ensuring that oncologists and decision-makers have access to comprehensive patient insights at the point of care, ultimately driving improved outcomes for cancer patients. Syapse has established strategic partnerships, including a collaboration with Pfizer, to further its mission of delivering personalized care based on robust real-world evidence.

Moxe

Series B in 2022
Moxe Health specializes in facilitating the exchange of clinical data between health plans and provider systems. Its platform, Substrate, enables real-time, bi-directional data transfer, including clinical, analytic, and administrative information. Moxe's solutions cover risk adjustment, quality metrics (like HEDIS and Star ratings), claims management, and care gap management, ensuring health plans and providers have the necessary data for value-based care. The company's neutrality allows seamless integration with existing systems, maximizing investments in population health and analytics.

Moxe

Venture Round in 2021
Moxe Health specializes in facilitating the exchange of clinical data between health plans and provider systems. Its platform, Substrate, enables real-time, bi-directional data transfer, including clinical, analytic, and administrative information. Moxe's solutions cover risk adjustment, quality metrics (like HEDIS and Star ratings), claims management, and care gap management, ensuring health plans and providers have the necessary data for value-based care. The company's neutrality allows seamless integration with existing systems, maximizing investments in population health and analytics.

Syapse

Series F in 2020
Syapse, Inc. is a technology company that specializes in precision medicine through its innovative software platform, which aggregates and analyzes clinical, molecular, treatment, and outcomes data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse aims to enhance healthcare by providing actionable insights that support data-driven decision-making in precision oncology. The company operates the Syapse Learning Health Network, a global network that enables health systems and life sciences collaborators to share real-world cancer data. This network empowers healthcare organizations to collaborate effectively, ensuring that oncologists and decision-makers have access to comprehensive patient insights at the point of care, ultimately driving improved outcomes for cancer patients. Syapse has established strategic partnerships, including a collaboration with Pfizer, to further its mission of delivering personalized care based on robust real-world evidence.

Trice Medical

Series C in 2019
Trice Medical, Inc. is a company that specializes in the development of innovative orthopedic diagnostic devices featuring integrated camera-enabled and needle-based technologies. Founded in 2011 and headquartered in Malvern, Pennsylvania, Trice Medical aims to enhance patient care by providing immediate and accurate diagnostic solutions that can be administered in a physician's office. Their products facilitate minimally invasive procedures that are designed to be painless, cosmetically undetectable, and of surgical grade quality. By optimizing the diagnostic process, Trice Medical seeks to eliminate inaccuracies associated with traditional indirect modalities, thereby reducing costs for the healthcare system while improving the overall patient experience.

InfoBionic

Venture Round in 2018
InfoBionic, Inc., incorporated in 2011 and based in Lowell, Massachusetts, specializes in remote patient monitoring technologies, particularly focusing on cardiac arrhythmia detection. The company has developed the MoMe System, a cloud-based platform that allows for continuous monitoring of electrocardiogram, respiration, and motion data. This wireless system streamlines the remote patient monitoring process, enhancing both clinical efficiency and patient care by enabling healthcare providers to access patient data anytime and anywhere. InfoBionic's innovative approach aims to transform the economics of cardiac diagnostic services, benefiting both physicians and patients through improved detection and treatment of cardiac complications.

Zipnosis

Series B in 2018
Zipnosis, Inc. operates a virtual healthcare platform that facilitates connections between patients and clinicians through phone and video interviews. Founded in 2008 and based in Minneapolis, Minnesota, the company specializes in online diagnosis, triage, and telehealth services. Its innovative platform is designed to enhance patient access to care while maximizing clinician efficiency and ensuring appropriate patient outcomes. Additionally, Zipnosis offers a ZipTicket, a healthcare boarding pass that allows patients to access clinics for in-person assessments or lab tests. By providing device-agnostic virtual care, Zipnosis aims to improve the overall healthcare experience for patients and health organizations alike.

meQuilibrium

Series C in 2018
meQuilibrium is a digital health company that provides online stress management solutions for individuals and employees. Its clinically validated platform leverages behavioral psychology, neuroscience, and analytics to deliver personalized insights and training programs aimed at enhancing resilience, improving mental well-being, and boosting overall business performance by increasing workforce agility and emotional control.

Propeller Health

Series D in 2018
Propeller Health is a digital health company focused on improving the management of chronic respiratory diseases such as asthma and COPD. The company offers a mobile platform that includes sensors, mobile apps, analytics, and services designed to support respiratory health management. The Propeller sensor attaches to users' inhalers and syncs wirelessly with their smartphones, tracking medication use, triggers, and symptoms. It provides personalized feedback and educational content based on the user's data. Users can set up medication reminders and alerts, and share their data with physicians and family members through the Propeller community. The platform is HIPAA compliant and stores users' data in a secure cloud infrastructure. Propeller Health collaborates with various healthcare organizations and has been recognized with several awards, including the TEDMED Innovation Showcase and White House Champion of Change. The company was founded by David Van Sickle, Greg Tracy, and Mark Gehring and is based in Wisconsin.

Prognos Health

Series C in 2017
Prognos Health is a health tech company focused on healthcare analytics, offering a platform called prognosFACTOR. This innovative platform can quickly query billions of lab and health records from over 325 million de-identified patients, providing answers to clinically relevant healthcare questions in a fraction of the time traditionally required. Prognos Health allows clients to access HIPAA-compliant, patient-centric healthcare data through the Prognos Marketplace, facilitating a range of applications such as cohort design, patient journey studies, and health outcomes analysis. The company's clientele includes 25 of the top 30 pharmaceutical manufacturers and three of the top five health payers, highlighting its significant role in empowering precise decision-making throughout the healthcare landscape.

Syapse

Series D in 2017
Syapse, Inc. is a technology company that specializes in precision medicine through its innovative software platform, which aggregates and analyzes clinical, molecular, treatment, and outcomes data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse aims to enhance healthcare by providing actionable insights that support data-driven decision-making in precision oncology. The company operates the Syapse Learning Health Network, a global network that enables health systems and life sciences collaborators to share real-world cancer data. This network empowers healthcare organizations to collaborate effectively, ensuring that oncologists and decision-makers have access to comprehensive patient insights at the point of care, ultimately driving improved outcomes for cancer patients. Syapse has established strategic partnerships, including a collaboration with Pfizer, to further its mission of delivering personalized care based on robust real-world evidence.

QuanticMind

Series B in 2017
QuanticMind Inc. is a software-as-a-service company specializing in predictive advertising management for paid search and social channels. Founded in 2011 and based in San Carlos, California, QuanticMind offers a platform that utilizes machine learning, distributed cloud computing, and in-memory processing to optimize advertising performance. Its flagship product, QuanticMind Shopping, integrates cross-channel and third-party data to extract actionable insights for informed advertising decisions. The platform is designed to help data-driven marketers anticipate and execute precise advertising investments, enhancing digital performance across various marketing channels. In addition to its software solutions, QuanticMind provides services such as data quality management, technical support, and training for users.

Trice Medical

Series C in 2017
Trice Medical, Inc. is a company that specializes in the development of innovative orthopedic diagnostic devices featuring integrated camera-enabled and needle-based technologies. Founded in 2011 and headquartered in Malvern, Pennsylvania, Trice Medical aims to enhance patient care by providing immediate and accurate diagnostic solutions that can be administered in a physician's office. Their products facilitate minimally invasive procedures that are designed to be painless, cosmetically undetectable, and of surgical grade quality. By optimizing the diagnostic process, Trice Medical seeks to eliminate inaccuracies associated with traditional indirect modalities, thereby reducing costs for the healthcare system while improving the overall patient experience.

T-REX

Series B in 2017
T-Rex Group, Inc., established in 2012, is a technology company specializing in enterprise Software-as-a-Service (SaaS) solutions. Based in New York, with offices in San Francisco and Tel Aviv, the company develops platforms tailored to the finance, renewables, and technology sectors. Its flagship product, T-REX Analytics, is an advanced SaaS analytics platform designed to analyze and manage solar asset acquisitions and sales, structure renewable energy-backed deals, and portfolio management. The platform enables solar developers and asset managers to stress test production and credit risk parameters, model customized debt tranches, and value securitization transactions. By digitizing and standardizing data, and automating workflows, T-Rex aims to facilitate capital flow into complex assets, fostering innovation in the renewable energy sector.

CloudMine

Series A in 2017
CloudMine is a developer of a mobile backend-as-a-service (mBaaS) platform focused on enhancing healthcare mobility and patient health. The platform offers object-based data storage, file storage modules, and capabilities for sending push notifications, facilitating effective communication with users. By operationalizing data through application development, analytics, and workflows, CloudMine enables healthcare and life science organizations to create secure, interoperable, and scalable applications more efficiently and at a reduced cost. The company's managed mobility solution also accelerates app development by 70% and eliminates the need for ongoing maintenance and management, providing a standardized mobility platform with IT-approved tools across various business units.

VitalTrax

Seed Round in 2017
VitalTrax connects patients with clinical trials with its cloud-based clinical trial network. VitalTrax offers Wing, a solution that simplifies clinical trials enrollment. Wing is a clinical trial network that provides innovative ways for people to easily seek optional treatments for themselves or people that they love and play an important role in helping develop new ways to fight diseases.

Velano Vascular

Series B in 2017
Velano Vascular, Inc. is a medical device company based in San Francisco, California, focused on innovating blood collection practices to enhance patient care and reduce associated risks. Founded in 2011, the company has developed the PIVO device, a needle-free and single-use sterile tool designed to draw blood from indwelling peripheral IV lines. This device aims to minimize the number of needle sticks and central line access required for blood collection. By enabling frequent and high-quality blood draws, the PIVO device seeks to deliver a more compassionate and efficient healthcare experience for hospital inpatients while also providing a safer solution for healthcare providers. Velano Vascular is dedicated to addressing the challenges of vascular access and improving the overall efficiency of blood collection in clinical settings.

Cognitive Operational Systems

Seed Round in 2017
Cognitive Operational Systems, LLC is an information technology company based in Philadelphia, Pennsylvania, specializing in inventory management solutions for the retail sector. Established in 2012, the company utilizes advanced robotics powered by computer vision and artificial intelligence to navigate retail environments. Its technology not only manages inventory and ensures compliance with planograms and promotions but also provides indoor localization and turn-by-turn navigation. Additionally, Cognitive Operational Systems maps retail layouts and architecture, integrating university research to develop practical industry applications in machine perception and software as a service.

Spongecell

Venture Round in 2016
Spongecell, Inc. is an advertising technology company based in New York City, founded in 2006. It specializes in designing and developing tools and services that enhance digital advertising, with a focus on transforming traditional banner ads into interactive formats that incorporate features such as video, mapping, and social media integration. Spongecell offers a Creative Management Platform that enables brand advertisers to create personalized ad experiences at scale, utilizing intelligent data integrations and decision-making tools. This platform allows marketers to deliver engaging content across various devices and formats, including display, mobile, and video, ultimately driving performance and return on investment. As of January 2018, Spongecell operates as a subsidiary of Simplicity Marketing Ltd.

Brickwork

Series A in 2016
Brickwork is a retail technology company that offers a Software as a Service (SaaS) platform designed to enhance the pre-visit experience for customers of major brands and retailers. Founded in 2013 and headquartered in New York, Brickwork's platform provides accurate store information, access to events and promotions, and personal assistance, ensuring customers are well-informed before visiting stores. The solution aims to bridge the gap between online and in-store shopping by managing critical store data and content, which helps brands improve decision-making and overall customer experience. Additionally, Brickwork's innovative approach includes measuring Digital-to-Store Conversion, allowing marketers and store teams to drive traffic, engagement, and increase sales.

Propeller Health

Series C in 2016
Propeller Health is a digital health company focused on improving the management of chronic respiratory diseases such as asthma and COPD. The company offers a mobile platform that includes sensors, mobile apps, analytics, and services designed to support respiratory health management. The Propeller sensor attaches to users' inhalers and syncs wirelessly with their smartphones, tracking medication use, triggers, and symptoms. It provides personalized feedback and educational content based on the user's data. Users can set up medication reminders and alerts, and share their data with physicians and family members through the Propeller community. The platform is HIPAA compliant and stores users' data in a secure cloud infrastructure. Propeller Health collaborates with various healthcare organizations and has been recognized with several awards, including the TEDMED Innovation Showcase and White House Champion of Change. The company was founded by David Van Sickle, Greg Tracy, and Mark Gehring and is based in Wisconsin.

Moxe

Series A in 2016
Moxe Health specializes in facilitating the exchange of clinical data between health plans and provider systems. Its platform, Substrate, enables real-time, bi-directional data transfer, including clinical, analytic, and administrative information. Moxe's solutions cover risk adjustment, quality metrics (like HEDIS and Star ratings), claims management, and care gap management, ensuring health plans and providers have the necessary data for value-based care. The company's neutrality allows seamless integration with existing systems, maximizing investments in population health and analytics.

Medcrypt

Seed Round in 2016
MedCrypt Inc. is a cybersecurity company specializing in the protection of medical devices. Founded in 2016 and based in Encinitas, California, MedCrypt provides data security solutions for a wide range of medical devices, including implantable devices like pacemakers and various surgical robots. The company's platform offers data security as a service to medical device original equipment manufacturers (OEMs), enabling them to implement essential security features quickly and efficiently. These features include user authentication, data encryption, and transaction monitoring to detect potential malicious behavior. By integrating security capabilities into medical devices with minimal code, MedCrypt allows engineers to focus on developing innovative clinical functionalities while ensuring the safety and integrity of device operations.

InfoBionic

Series B in 2016
InfoBionic, Inc., incorporated in 2011 and based in Lowell, Massachusetts, specializes in remote patient monitoring technologies, particularly focusing on cardiac arrhythmia detection. The company has developed the MoMe System, a cloud-based platform that allows for continuous monitoring of electrocardiogram, respiration, and motion data. This wireless system streamlines the remote patient monitoring process, enhancing both clinical efficiency and patient care by enabling healthcare providers to access patient data anytime and anywhere. InfoBionic's innovative approach aims to transform the economics of cardiac diagnostic services, benefiting both physicians and patients through improved detection and treatment of cardiac complications.

Aktana

Series B in 2016
Aktana Inc. is a technology company that specializes in AI-enabled marketing decision support software tailored for the life sciences sector. Founded in 2008 and headquartered in San Francisco, Aktana develops a platform that utilizes machine learning algorithms to assist sales and marketing teams in optimizing their engagement with healthcare professionals. Its key offerings include the Contextual Intelligence Engine, which allows executives to simulate various marketing strategies, and the Decision Support Engine, which analyzes diverse data sources to provide actionable insights directly within the representative’s existing CRM workflows. By focusing exclusively on the life sciences market, Aktana delivers data-driven suggestions that enhance multichannel marketing initiatives and improve overall campaign effectiveness. The company supports over 100 brands, including more than half of the top 20 pharmaceutical companies globally, helping them to maximize revenue and utilize data investments efficiently. Additionally, Aktana has offices in several international locations, including Tokyo, Shanghai, and Barcelona.

Noble.MD

Seed Round in 2016
Noble.MD is a healthcare technology company based in Bryn Mawr, Pennsylvania, founded in 2012. It develops Theo, a digital healthcare advisory platform designed to identify health and behavioral risks for patients. The platform enables patients to actively manage these risks through tailored programs and interventions. By capturing essential patient data at the point of care, Noble.MD facilitates value-based reimbursement and aligns the interests of providers and payers, enhancing the processes of risk identification, coding, and management. Through its innovative approach, Noble.MD engages patients in understanding their symptoms, behaviors, and intentions, while encouraging actionable steps towards improved health outcomes.

Transactis

Series E in 2016
Transactis, Inc. is a New York-based company specializing in Software-as-a-Service solutions for electronic bill presentment and payment. Established in 2001, Transactis enables businesses to transition from traditional paper-based billing to efficient digital alternatives. Its primary offerings include BillerIQ, a cloud platform for delivering electronic bills and accepting online, phone, and mobile payments, and DocumentIQ, a digital document management system for transforming and archiving documents. The company serves a diverse array of industries, including financial services, healthcare, utilities, and retail, among others. Operating solely through a network of resellers, which include financial institutions and technology companies, Transactis provides white-label SaaS solutions along with substantial sales, marketing, and technical support to empower its partners. The company adheres to rigorous regulatory standards, ensuring compliance with regulations such as HIPAA and PCI Level 1.

Velano Vascular

Series A in 2016
Velano Vascular, Inc. is a medical device company based in San Francisco, California, focused on innovating blood collection practices to enhance patient care and reduce associated risks. Founded in 2011, the company has developed the PIVO device, a needle-free and single-use sterile tool designed to draw blood from indwelling peripheral IV lines. This device aims to minimize the number of needle sticks and central line access required for blood collection. By enabling frequent and high-quality blood draws, the PIVO device seeks to deliver a more compassionate and efficient healthcare experience for hospital inpatients while also providing a safer solution for healthcare providers. Velano Vascular is dedicated to addressing the challenges of vascular access and improving the overall efficiency of blood collection in clinical settings.

Syapse

Series C in 2016
Syapse, Inc. is a technology company that specializes in precision medicine through its innovative software platform, which aggregates and analyzes clinical, molecular, treatment, and outcomes data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse aims to enhance healthcare by providing actionable insights that support data-driven decision-making in precision oncology. The company operates the Syapse Learning Health Network, a global network that enables health systems and life sciences collaborators to share real-world cancer data. This network empowers healthcare organizations to collaborate effectively, ensuring that oncologists and decision-makers have access to comprehensive patient insights at the point of care, ultimately driving improved outcomes for cancer patients. Syapse has established strategic partnerships, including a collaboration with Pfizer, to further its mission of delivering personalized care based on robust real-world evidence.

Zipnosis

Series A in 2016
Zipnosis, Inc. operates a virtual healthcare platform that facilitates connections between patients and clinicians through phone and video interviews. Founded in 2008 and based in Minneapolis, Minnesota, the company specializes in online diagnosis, triage, and telehealth services. Its innovative platform is designed to enhance patient access to care while maximizing clinician efficiency and ensuring appropriate patient outcomes. Additionally, Zipnosis offers a ZipTicket, a healthcare boarding pass that allows patients to access clinics for in-person assessments or lab tests. By providing device-agnostic virtual care, Zipnosis aims to improve the overall healthcare experience for patients and health organizations alike.

Cask

Series B in 2015
Cask is an open-source software company based in Palo Alto, California, that specializes in simplifying the construction and operation of big data solutions. The company offers a unified integration platform that significantly accelerates the time required to deploy data applications and data lakes, reducing it by up to 80%. Cask's platform combines data integration and application development capabilities, facilitating rapid development in both public and private cloud environments. The company is supported by prominent investors, including Battery Ventures, Andreessen Horowitz, and Ignition Partners.

QuanticMind

Series A in 2015
QuanticMind Inc. is a software-as-a-service company specializing in predictive advertising management for paid search and social channels. Founded in 2011 and based in San Carlos, California, QuanticMind offers a platform that utilizes machine learning, distributed cloud computing, and in-memory processing to optimize advertising performance. Its flagship product, QuanticMind Shopping, integrates cross-channel and third-party data to extract actionable insights for informed advertising decisions. The platform is designed to help data-driven marketers anticipate and execute precise advertising investments, enhancing digital performance across various marketing channels. In addition to its software solutions, QuanticMind provides services such as data quality management, technical support, and training for users.

Sonobi

Series A in 2015
Sonobi, Inc. is an advertising technology company based in Winter Park, Florida, founded in 2011. It offers a platform that connects publishers, advertisers, and media agencies, facilitating the marketing and positioning of advertising opportunities. By utilizing user-centric technology and intelligent data, Sonobi enables clients to drive results and achieve their business goals through more effective advertising strategies. The platform includes tools for both buy and sell sides of the advertising market, allowing users to identify, deliver, and manage advertising opportunities efficiently. Additionally, Sonobi provides a Consent Management Platform, designed to help publishers ensure compliance with privacy regulations while maintaining transparent consent processes. Overall, Sonobi aims to create a fair and equitable media marketplace, fostering better connections between brands and individuals.

Apprenda

Series D in 2015
Apprenda is a developer of a cloud-based enterprise platform that enhances enterprise software development. Established in 2007 and headquartered in Troy, New York, the company specializes in creating modern application platforms suitable for both cloud-native and traditional workloads. Apprenda's offerings enable enterprise IT to build a Kubernetes-enabled shared service on various infrastructures, facilitating collaboration among developers across different business units. By streamlining the software delivery process, Apprenda aims to transform IT into a dynamic engine of growth for organizations, drawing on over a decade of insights from enterprise customers.

Pneuron

Series B in 2015
Pneuron Corp., established in 2010 and headquartered in Atlanta, Georgia, specializes in designing and deploying business orchestration software solutions. Its core product, Pneuron, is a distributed platform that enhances existing applications, infrastructure, services, and data to generate actionable intelligence. The platform comprises Cortex, which manages processing, messaging, and resiliency, Pneurons (mini-applications), and Design Studio for configuring and connecting Pneurons. Pneuron enables organizations to leverage their existing systems, connect data and applications, and manage the entire business solution lifecycle from a single screen, thereby reducing costs, enhancing productivity, and fostering innovation. As of 2018, Pneuron operates as a subsidiary of UST Global Inc.

Clutch

Series B in 2015
Clutch Holdings, LLC specializes in developing customer intelligence and engagement software solutions. The company offers a comprehensive consumer management platform that integrates point-of-sale, e-commerce data, and consumer social and mobile activities to enhance customer connections. Clutch provides a range of services including customer relationship management, channel synthesis, segmentation, loyalty programs, gift card solutions, and marketing strategies such as email campaigns and direct mail. Its platform is designed to centralize information from various data sources, enabling businesses to identify, understand, and motivate their customers effectively. Clutch serves a diverse array of sectors, including footwear, telecommunications, apparel, automotive, banking, healthcare, and hospitality. Founded in 2012 and based in Ambler, Pennsylvania, Clutch aims to empower brands with innovative, data-driven marketing solutions to thrive in a dynamic marketing landscape.

Full Measure Education

Series B in 2015
Full Measure Education, Inc. is a Washington, D.C.-based company that develops a mobile engagement platform aimed at enhancing the student experience in higher education. Founded in 2013, the company provides a suite of tools designed to assist students in managing their administrative needs while also addressing retention challenges faced by colleges and universities. Its platform includes features such as messaging inboxes, custom auto-responses, campaign management, and data reporting, all of which facilitate effective communication and support throughout the student lifecycle, from admission to graduation. Drawing on extensive experience from over 10 million student help desk interactions across more than 850 institutions, Full Measure Education aims to improve key metrics such as retention rates, enrollment growth, and operational efficiency for educational institutions.

meQuilibrium

Series B in 2015
meQuilibrium is a digital health company that provides online stress management solutions for individuals and employees. Its clinically validated platform leverages behavioral psychology, neuroscience, and analytics to deliver personalized insights and training programs aimed at enhancing resilience, improving mental well-being, and boosting overall business performance by increasing workforce agility and emotional control.

CloudMine

Series A in 2015
CloudMine is a developer of a mobile backend-as-a-service (mBaaS) platform focused on enhancing healthcare mobility and patient health. The platform offers object-based data storage, file storage modules, and capabilities for sending push notifications, facilitating effective communication with users. By operationalizing data through application development, analytics, and workflows, CloudMine enables healthcare and life science organizations to create secure, interoperable, and scalable applications more efficiently and at a reduced cost. The company's managed mobility solution also accelerates app development by 70% and eliminates the need for ongoing maintenance and management, providing a standardized mobility platform with IT-approved tools across various business units.

Aventura Software

Series C in 2015
Aventura intelligently orchestrates assets, people, and systems to deliver the right information at the right time based on location and credentials. It locates and re-assigns the closest online printer and uniquely manages print routing to make it easier to detect and fix printing failures. Aventura was formed in 2007 and headquartered in Denver, Colorado.

Velano Vascular

Series A in 2015
Velano Vascular, Inc. is a medical device company based in San Francisco, California, focused on innovating blood collection practices to enhance patient care and reduce associated risks. Founded in 2011, the company has developed the PIVO device, a needle-free and single-use sterile tool designed to draw blood from indwelling peripheral IV lines. This device aims to minimize the number of needle sticks and central line access required for blood collection. By enabling frequent and high-quality blood draws, the PIVO device seeks to deliver a more compassionate and efficient healthcare experience for hospital inpatients while also providing a safer solution for healthcare providers. Velano Vascular is dedicated to addressing the challenges of vascular access and improving the overall efficiency of blood collection in clinical settings.

Trice Medical

Series B in 2015
Trice Medical, Inc. is a company that specializes in the development of innovative orthopedic diagnostic devices featuring integrated camera-enabled and needle-based technologies. Founded in 2011 and headquartered in Malvern, Pennsylvania, Trice Medical aims to enhance patient care by providing immediate and accurate diagnostic solutions that can be administered in a physician's office. Their products facilitate minimally invasive procedures that are designed to be painless, cosmetically undetectable, and of surgical grade quality. By optimizing the diagnostic process, Trice Medical seeks to eliminate inaccuracies associated with traditional indirect modalities, thereby reducing costs for the healthcare system while improving the overall patient experience.

Propeller Health

Series B in 2014
Propeller Health is a digital health company focused on improving the management of chronic respiratory diseases such as asthma and COPD. The company offers a mobile platform that includes sensors, mobile apps, analytics, and services designed to support respiratory health management. The Propeller sensor attaches to users' inhalers and syncs wirelessly with their smartphones, tracking medication use, triggers, and symptoms. It provides personalized feedback and educational content based on the user's data. Users can set up medication reminders and alerts, and share their data with physicians and family members through the Propeller community. The platform is HIPAA compliant and stores users' data in a secure cloud infrastructure. Propeller Health collaborates with various healthcare organizations and has been recognized with several awards, including the TEDMED Innovation Showcase and White House Champion of Change. The company was founded by David Van Sickle, Greg Tracy, and Mark Gehring and is based in Wisconsin.

Transactis

Series D in 2014
Transactis, Inc. is a New York-based company specializing in Software-as-a-Service solutions for electronic bill presentment and payment. Established in 2001, Transactis enables businesses to transition from traditional paper-based billing to efficient digital alternatives. Its primary offerings include BillerIQ, a cloud platform for delivering electronic bills and accepting online, phone, and mobile payments, and DocumentIQ, a digital document management system for transforming and archiving documents. The company serves a diverse array of industries, including financial services, healthcare, utilities, and retail, among others. Operating solely through a network of resellers, which include financial institutions and technology companies, Transactis provides white-label SaaS solutions along with substantial sales, marketing, and technical support to empower its partners. The company adheres to rigorous regulatory standards, ensuring compliance with regulations such as HIPAA and PCI Level 1.

WebLinc

Series A in 2014
WebLinc is a provider of ecommerce solutions, offering the Workarea Commerce Cloud platform and the Orderbot order management system. These modern technologies are designed to support global, omnichannel commerce operations, helping retailers enhance their competitive edge. WebLinc serves a diverse range of successful retail and B2B clients, including well-known brands such as URBN's BHLDN and Terrain, Sanrio, The Reformation, STAPLES Canada, Buzzfeed, Live Nation, Woodcraft Supplies, and The Bouqs. The company's focus on agility and strategic expertise enables its clients to thrive in the rapidly evolving online retail landscape.

Trice Medical

Series B in 2014
Trice Medical, Inc. is a company that specializes in the development of innovative orthopedic diagnostic devices featuring integrated camera-enabled and needle-based technologies. Founded in 2011 and headquartered in Malvern, Pennsylvania, Trice Medical aims to enhance patient care by providing immediate and accurate diagnostic solutions that can be administered in a physician's office. Their products facilitate minimally invasive procedures that are designed to be painless, cosmetically undetectable, and of surgical grade quality. By optimizing the diagnostic process, Trice Medical seeks to eliminate inaccuracies associated with traditional indirect modalities, thereby reducing costs for the healthcare system while improving the overall patient experience.

Syapse

Series B in 2014
Syapse, Inc. is a technology company that specializes in precision medicine through its innovative software platform, which aggregates and analyzes clinical, molecular, treatment, and outcomes data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse aims to enhance healthcare by providing actionable insights that support data-driven decision-making in precision oncology. The company operates the Syapse Learning Health Network, a global network that enables health systems and life sciences collaborators to share real-world cancer data. This network empowers healthcare organizations to collaborate effectively, ensuring that oncologists and decision-makers have access to comprehensive patient insights at the point of care, ultimately driving improved outcomes for cancer patients. Syapse has established strategic partnerships, including a collaboration with Pfizer, to further its mission of delivering personalized care based on robust real-world evidence.

Lumesis

Series B in 2014
Lumesis, Inc., founded in 2010 and based in Stamford, Connecticut, is a financial technology company specializing in regulatory and data solutions for the municipal market. It offers several key products under the DIVER brand: DIVER Analytics provides access to numerous datasets and analytical tools tailored to address challenges like stale financials and fiscal uncertainty; DIVER Advisor supports evolving regulatory needs related to time-of-trade disclosure, supervision, and suitability; DIVER Data Services delivers custom datasets formatted for client platforms; and DIVER Geo Score assesses the economic health of specific geographic areas. Lumesis serves a diverse clientele including U.S. banks, broker/dealers, asset managers, insurance companies, hedge funds, and financial advisors.

MediaMath

Series C in 2014
MediaMath, Inc. is a digital advertising technology company that specializes in providing solutions for advertisers globally. Founded in 2007 and headquartered in New York, the company offers its TerminalOne platform, which facilitates data activation, automated execution, and optimization of advertising interactions across various media channels. MediaMath's programmatic marketing platform enhances customer engagement by utilizing predictive audience targeting and machine learning to ensure relevant messaging. In addition to its technology offerings, the company provides professional services that include programmatic strategy, analytics, technology support, and advertising operations, as well as training and certification programs in digital marketing. MediaMath operates additional offices in several cities across the United States and internationally, including London, Madrid, Berlin, Singapore, Tokyo, Sao Paulo, Sydney, Melbourne, and Bengaluru.

Sotera Wireless

Venture Round in 2014
Sotera Wireless, Inc. is a medical device company dedicated to the development, marketing and sale of a new generation of comprehensive vital signs monitoring. Sotera’s mission is to improve patient safety by empowering clinicians to detect early signs of deterioration in virtually any care setting and enable early intervention and rapid response, all without limiting the patient’s freedom of movement.

InfoBionic

Series B in 2014
InfoBionic, Inc., incorporated in 2011 and based in Lowell, Massachusetts, specializes in remote patient monitoring technologies, particularly focusing on cardiac arrhythmia detection. The company has developed the MoMe System, a cloud-based platform that allows for continuous monitoring of electrocardiogram, respiration, and motion data. This wireless system streamlines the remote patient monitoring process, enhancing both clinical efficiency and patient care by enabling healthcare providers to access patient data anytime and anywhere. InfoBionic's innovative approach aims to transform the economics of cardiac diagnostic services, benefiting both physicians and patients through improved detection and treatment of cardiac complications.

Hoopla

Series B in 2014
Hoopla is the new way to win for sales, marketing and customer service teams. Hoopla’s team performance software combines modern game mechanics, data analytics and broadcast-quality video in a powerfully simple application that makes it easy for front-line managers to motivate team performance and score more wins. Using Hoopla, managers can quickly create contests, competitions and leaderboards around any CRM metric, and broadcast live performance updates to TV, web and mobile screens throughout the company. Hoopla's Sales Motivation solutions engage the entire company in an exciting, play-to-win culture that delivers measurable gains in team productivity and performance. Founded in 2010, Hoopla is headquartered in Silicon Valley.

Apprenda

Series C in 2013
Apprenda is a developer of a cloud-based enterprise platform that enhances enterprise software development. Established in 2007 and headquartered in Troy, New York, the company specializes in creating modern application platforms suitable for both cloud-native and traditional workloads. Apprenda's offerings enable enterprise IT to build a Kubernetes-enabled shared service on various infrastructures, facilitating collaboration among developers across different business units. By streamlining the software delivery process, Apprenda aims to transform IT into a dynamic engine of growth for organizations, drawing on over a decade of insights from enterprise customers.

Dabo Health

Series A in 2013
Dabo Health provides the healthcare community a free platform to view and track improvement in key performance metrics, to collaborate across hospitals and healthcare systems, and to identify and share evidence based best practices in order to save lives. In the era of Big Data, we enlighten individuals, organizations and industries and empower fundamental change at all levels. By combining human-powered insights with raw, objective data, we inform confident decisions and drive efficiencies. Ours is a system that rewards collaboration with innovative ideas that are integral to the progression of humanity. We call it “The Power of Collective Intelligence.” We channel this shared knowledge of passionate professionals to empower progress.

Clutch

Venture Round in 2013
Clutch Holdings, LLC specializes in developing customer intelligence and engagement software solutions. The company offers a comprehensive consumer management platform that integrates point-of-sale, e-commerce data, and consumer social and mobile activities to enhance customer connections. Clutch provides a range of services including customer relationship management, channel synthesis, segmentation, loyalty programs, gift card solutions, and marketing strategies such as email campaigns and direct mail. Its platform is designed to centralize information from various data sources, enabling businesses to identify, understand, and motivate their customers effectively. Clutch serves a diverse array of sectors, including footwear, telecommunications, apparel, automotive, banking, healthcare, and hospitality. Founded in 2012 and based in Ambler, Pennsylvania, Clutch aims to empower brands with innovative, data-driven marketing solutions to thrive in a dynamic marketing landscape.

Quantia

Series B in 2013
QuantiaMD is the largest online community and collaboration platform designed specifically for physicians. It facilitates the sharing of real-life clinical experiences among a network of 160,000 physicians, enabling rapid adaptation to changes in the medical field and the application of the latest medical knowledge in practice. The platform serves as a mobile and web-based physician relationship management system, incorporating elements of social media and engagement science to enhance communication between healthcare organizations and physicians. By providing an easy-to-use and secure environment, QuantiaMD allows healthcare companies to engage and align physicians effectively, ultimately aiming to improve the quality of care delivered to patients.

Prognos Health

Series B in 2013
Prognos Health is a health tech company focused on healthcare analytics, offering a platform called prognosFACTOR. This innovative platform can quickly query billions of lab and health records from over 325 million de-identified patients, providing answers to clinically relevant healthcare questions in a fraction of the time traditionally required. Prognos Health allows clients to access HIPAA-compliant, patient-centric healthcare data through the Prognos Marketplace, facilitating a range of applications such as cohort design, patient journey studies, and health outcomes analysis. The company's clientele includes 25 of the top 30 pharmaceutical manufacturers and three of the top five health payers, highlighting its significant role in empowering precise decision-making throughout the healthcare landscape.

Pneuron

Series B in 2013
Pneuron Corp., established in 2010 and headquartered in Atlanta, Georgia, specializes in designing and deploying business orchestration software solutions. Its core product, Pneuron, is a distributed platform that enhances existing applications, infrastructure, services, and data to generate actionable intelligence. The platform comprises Cortex, which manages processing, messaging, and resiliency, Pneurons (mini-applications), and Design Studio for configuring and connecting Pneurons. Pneuron enables organizations to leverage their existing systems, connect data and applications, and manage the entire business solution lifecycle from a single screen, thereby reducing costs, enhancing productivity, and fostering innovation. As of 2018, Pneuron operates as a subsidiary of UST Global Inc.

Sotera Wireless

Series D in 2013
Sotera Wireless, Inc. is a medical device company dedicated to the development, marketing and sale of a new generation of comprehensive vital signs monitoring. Sotera’s mission is to improve patient safety by empowering clinicians to detect early signs of deterioration in virtually any care setting and enable early intervention and rapid response, all without limiting the patient’s freedom of movement.

Crescendo Bioscience

Series D in 2013
Crescendo Bioscience, Inc. is a molecular diagnostics company specializing in rheumatology, founded in 2002 and located in South San Francisco, California. The company develops quantitative and objective diagnostic tools aimed at assisting rheumatologists in the management of autoimmune and inflammatory diseases. Its primary product, Vectra DA, is a standardized multi-biomarker blood test designed to assess disease activity in rheumatoid arthritis. This test enables rheumatologists to effectively monitor and manage patients by providing critical disease information and insights. Through its innovative diagnostic and prognostic capabilities, Crescendo Bioscience enhances the decision-making process for therapy selection and patient management.

AppFirst

Series B in 2012
AppFirst’s is a patented technology that provides a solution for collecting every event across web-scale applications, regardless of the infrastructure type or programming language. With microsecond visibility into all the applications and supporting resources across their shared infrastructure, IT Operations can now deterministically get to the root cause, effectively footprint applications to determine exactly what resources that application requires, and proactively identify when their applications become wobbly. Those responsible for the infrastructure finally have a way to continuously understand the performance of every application running on the shared-resources they own.

Hoopla

Series A in 2012
Hoopla is the new way to win for sales, marketing and customer service teams. Hoopla’s team performance software combines modern game mechanics, data analytics and broadcast-quality video in a powerfully simple application that makes it easy for front-line managers to motivate team performance and score more wins. Using Hoopla, managers can quickly create contests, competitions and leaderboards around any CRM metric, and broadcast live performance updates to TV, web and mobile screens throughout the company. Hoopla's Sales Motivation solutions engage the entire company in an exciting, play-to-win culture that delivers measurable gains in team productivity and performance. Founded in 2010, Hoopla is headquartered in Silicon Valley.

Good Start Genetics

Series B in 2012
Good Start Genetics, Inc. is a molecular diagnostics company based in Cambridge, Massachusetts, founded in 2007. It specializes in genetic screening for inherited diseases, aiming to transform reproductive medicine by providing actionable information to physicians and patients. The company offers a range of services, including EmbryVu, a preimplantation genetic screening test designed to enhance in vitro fertilization outcomes by identifying suitable embryos for implantation. Additionally, Good Start Genetics provides a comprehensive array of genetic carrier screening tests through its GoodStart Select program, utilizing advanced next-generation DNA sequencing technology along with other established genetic screening methods. This focus on high carrier detection rates and commitment to customer care and genetic counseling positions the company as a leader in the field of pre-pregnancy genetic testing and diagnostics. As of August 2017, Good Start Genetics operates as a subsidiary of Invitae Corporation.

Lumesis

Series A in 2012
Lumesis, Inc., founded in 2010 and based in Stamford, Connecticut, is a financial technology company specializing in regulatory and data solutions for the municipal market. It offers several key products under the DIVER brand: DIVER Analytics provides access to numerous datasets and analytical tools tailored to address challenges like stale financials and fiscal uncertainty; DIVER Advisor supports evolving regulatory needs related to time-of-trade disclosure, supervision, and suitability; DIVER Data Services delivers custom datasets formatted for client platforms; and DIVER Geo Score assesses the economic health of specific geographic areas. Lumesis serves a diverse clientele including U.S. banks, broker/dealers, asset managers, insurance companies, hedge funds, and financial advisors.

Spongecell

Series B in 2012
Spongecell, Inc. is an advertising technology company based in New York City, founded in 2006. It specializes in designing and developing tools and services that enhance digital advertising, with a focus on transforming traditional banner ads into interactive formats that incorporate features such as video, mapping, and social media integration. Spongecell offers a Creative Management Platform that enables brand advertisers to create personalized ad experiences at scale, utilizing intelligent data integrations and decision-making tools. This platform allows marketers to deliver engaging content across various devices and formats, including display, mobile, and video, ultimately driving performance and return on investment. As of January 2018, Spongecell operates as a subsidiary of Simplicity Marketing Ltd.

Hoopla

Series A in 2011
Hoopla is the new way to win for sales, marketing and customer service teams. Hoopla’s team performance software combines modern game mechanics, data analytics and broadcast-quality video in a powerfully simple application that makes it easy for front-line managers to motivate team performance and score more wins. Using Hoopla, managers can quickly create contests, competitions and leaderboards around any CRM metric, and broadcast live performance updates to TV, web and mobile screens throughout the company. Hoopla's Sales Motivation solutions engage the entire company in an exciting, play-to-win culture that delivers measurable gains in team productivity and performance. Founded in 2010, Hoopla is headquartered in Silicon Valley.

DriveFactor

Series A in 2011
DriveFactor, founded in 2010 and headquartered in Glen Allen, Virginia, is a company specializing in insurance telematics technology solutions. It offers a software platform that analyzes driving data and provides insurance companies with a comprehensive system for underwriting driving insurance based on a proprietary metric known as the DriveFactor Score. The platform features a dynamic, scalable architecture that accommodates various data input methods, facilitating easy integration and data sharing with business partners. By leveraging its technological expertise, DriveFactor enables clients to customize telematics solutions tailored to both short-term and long-term requirements.

Prognos Health

Series A in 2011
Prognos Health is a health tech company focused on healthcare analytics, offering a platform called prognosFACTOR. This innovative platform can quickly query billions of lab and health records from over 325 million de-identified patients, providing answers to clinically relevant healthcare questions in a fraction of the time traditionally required. Prognos Health allows clients to access HIPAA-compliant, patient-centric healthcare data through the Prognos Marketplace, facilitating a range of applications such as cohort design, patient journey studies, and health outcomes analysis. The company's clientele includes 25 of the top 30 pharmaceutical manufacturers and three of the top five health payers, highlighting its significant role in empowering precise decision-making throughout the healthcare landscape.

Putney

Series C in 2011
Putney, Inc. is a pharmaceutical company based in Portland, Maine, specializing in the development and sale of generic prescription medications for pets. Founded in 2006, the company focuses on creating high-quality, veterinary-approved products that address common health issues in companion animals. Its product portfolio includes medications such as Enrofloxacin tablets for bacterial infections, Cefpodoxime Proxetil tablets for skin infections, and Carprofen caplets for pain management in dogs. Additionally, Putney offers human-approved products like Ampicillin sodium for injection. The company markets its drugs through a network of distributors across the United States, aiming to improve access to essential medications for veterinarians and pet owners. As of 2016, Putney operates as a subsidiary of Dechra Pharmaceuticals plc.

NovaSom

Series D in 2011
NovaSom Inc., established in 1992 and headquartered in Glen Burnie, Maryland, specializes in home-based diagnostic services for sleep-disordered breathing conditions, notably obstructive sleep apnea (OSA). As a Medicare-approved Independent Diagnostic Testing Facility and Joint Commission-accredited provider, NovaSom offers FDA-cleared home testing systems. Their cloud-based platform facilitates collaborative patient management between physicians and payers, ensuring efficient, accurate, and comfortable evaluations for patients in their own homes.

PixelOptics

Series D in 2011
PixelOptics was founded in 2005 as the world's first composite lens company. Their unique and proprietary approach to lens design combines sound lens design principles and well-known, proven lens materials to create entirely new categories of eyeglass lenses.

ThingWorx

Series B in 2011
ThingWorx is a developer of a software application platform that facilitates the connection of people, systems, and devices in the modern digital landscape. The company specializes in creating and deploying secure connected applications across various environments, including cloud, intranet, and embedded platforms. By leveraging its technology, ThingWorx aims to drive significant operational innovation and enhance resource efficiency for businesses. Its solutions are designed to enable organizations to implement transformative changes that contribute to a more efficient and sustainable world.

Good Start Genetics

Series A in 2010
Good Start Genetics, Inc. is a molecular diagnostics company based in Cambridge, Massachusetts, founded in 2007. It specializes in genetic screening for inherited diseases, aiming to transform reproductive medicine by providing actionable information to physicians and patients. The company offers a range of services, including EmbryVu, a preimplantation genetic screening test designed to enhance in vitro fertilization outcomes by identifying suitable embryos for implantation. Additionally, Good Start Genetics provides a comprehensive array of genetic carrier screening tests through its GoodStart Select program, utilizing advanced next-generation DNA sequencing technology along with other established genetic screening methods. This focus on high carrier detection rates and commitment to customer care and genetic counseling positions the company as a leader in the field of pre-pregnancy genetic testing and diagnostics. As of August 2017, Good Start Genetics operates as a subsidiary of Invitae Corporation.

Swaptree

Series D in 2010
Swaptree is a website that allows users to trade books, CDs, DVDs and video games with other users for freeSwaptree.com provides a platform for trading among its customers. The Company offers a site where the user can freely swap new and used DVDs, CDs, video games, and books with other members. Swaptree.com conducts services in the United States.

Molecular Biometrics

Series B in 2010
Molecular Biometrics, Inc. is a metabolomics company based in Norwood, Massachusetts, established in 2005. The company specializes in developing innovative, non-invasive methodologies that utilize novel metabolomic technologies to assess normal biological functions related to health and disease, as well as to facilitate drug discovery and development. Its proprietary technology has applications in various medical fields, including reproductive health, neurodegenerative diseases such as Alzheimer's and Parkinson's, maternal-fetal medicine, as well as pulmonary metabolism and edema, and lactate metabolism. Through its focus on metabolomics, Molecular Biometrics aims to enhance understanding and evaluation of biological processes and improve clinical outcomes.

Quinnova Pharmaceuticals

Series B in 2009
Quinnova Pharmaceuticals, Inc., a specialty pharmaceutical company, engages in the development and commercial sale of prescription drug products based on dermal drug delivery platforms. It offers HYDRO 40 foam, a dry skin treatment product; tersi foam, a leave-on foam indicated for the treatment of seborrheic dermatitis and tinea versicolor; rinnovi nail system, a prescription nail system that is designed to clean, treat, and protect diseased, damaged, brittle, and ingrown nails; and cleanse and treat, a pad delivery technology system for the treatment of acne. Quinnova Pharmaceuticals, Inc. was founded in 2003 and is based in Newtown, Pennsylvania.

MediaMath

Venture Round in 2009
MediaMath, Inc. is a digital advertising technology company that specializes in providing solutions for advertisers globally. Founded in 2007 and headquartered in New York, the company offers its TerminalOne platform, which facilitates data activation, automated execution, and optimization of advertising interactions across various media channels. MediaMath's programmatic marketing platform enhances customer engagement by utilizing predictive audience targeting and machine learning to ensure relevant messaging. In addition to its technology offerings, the company provides professional services that include programmatic strategy, analytics, technology support, and advertising operations, as well as training and certification programs in digital marketing. MediaMath operates additional offices in several cities across the United States and internationally, including London, Madrid, Berlin, Singapore, Tokyo, Sao Paulo, Sydney, Melbourne, and Bengaluru.

Avid Radiopharmaceuticals

Series D in 2009
Avid Radiopharmaceuticals is a Philadelphia-based company focused on the development of molecular imaging agents designed to enhance the medical management of chronic diseases. Its mission centers on creating innovative imaging compounds that facilitate the early identification of pathological changes, thereby supporting earlier diagnosis and improved management of various conditions. Avid's notable product, Amyvid, is an imaging tool utilized in positron emission tomography to detect beta-amyloid plaques in the brain, which plays a crucial role in the assessment of Alzheimer's disease. Through its advancements in molecular imaging, Avid aims to contribute to the development of new therapies and improve clinical outcomes for patients suffering from significant chronic illnesses.

Updater Home Services (formerly Bridgevine)

Venture Round in 2009
Bridgevine Inc. is a provider of a cloud-based marketing automation platform focused on customer acquisition for the digital home service and small business markets. The company's Digital Commerce Platform enables users to effectively engage with customers and prospects by presenting tailored offers across various devices, optimizing product positioning, and facilitating cross-selling opportunities. Bridgevine also offers specialized services such as Audience Optimization, which targets consumers at different stages of their shopping journey, and the Mover Media Program, a managed marketing initiative that utilizes proprietary audiences and algorithms. Additionally, the company supports a referral platform called Acquily and provides a suite of digital engagement and customer acquisition tools. Bridgevine serves a diverse clientele, including media and OTT service providers, utilities, and retailers, and is recognized for its utility and affiliate programs with major energy companies in the United States. Founded in 2003 and based in Vero Beach, Florida, Bridgevine operates as a subsidiary of Updater, Inc. following its rebranding from Broadband National, Inc. in 2006.

Garnet Biotherapeutics

Series A in 2009
Garnet BioTherapeutics is a clinical stage, venture-backed cell therapy company focused on dermal-based regenerative therapy.

Tengion

Series C in 2008
Tengion is a clinical-stage biotechnology company focused on developing neo-organs and neo-tissues derived from a patient's own cells. The company has made significant advancements in regenerative medicine, particularly with its Tengion Neo-Bladder Augment, which has undergone two Phase 2 human clinical trials in the United States for treating neurogenic bladder conditions in both children and adults. Additionally, Tengion is preparing to initiate a Phase 1 clinical trial for its Neo-Urinary Conduit, aimed at bladder cancer patients who require bladder removal. The company's innovative approach seeks to eliminate the need for donor organs and reduce reliance on anti-rejection medications by creating living tissue products that can regenerate or replace damaged organs.

Molecular Biometrics

Series A in 2008
Molecular Biometrics, Inc. is a metabolomics company based in Norwood, Massachusetts, established in 2005. The company specializes in developing innovative, non-invasive methodologies that utilize novel metabolomic technologies to assess normal biological functions related to health and disease, as well as to facilitate drug discovery and development. Its proprietary technology has applications in various medical fields, including reproductive health, neurodegenerative diseases such as Alzheimer's and Parkinson's, maternal-fetal medicine, as well as pulmonary metabolism and edema, and lactate metabolism. Through its focus on metabolomics, Molecular Biometrics aims to enhance understanding and evaluation of biological processes and improve clinical outcomes.

Swaptree

Series C in 2008
Swaptree is a website that allows users to trade books, CDs, DVDs and video games with other users for freeSwaptree.com provides a platform for trading among its customers. The Company offers a site where the user can freely swap new and used DVDs, CDs, video games, and books with other members. Swaptree.com conducts services in the United States.

NuPathe

Series B in 2008
NuPathe Inc., a Pennsylvania-based specialty pharmaceutical company, specializes in developing and commercializing branded therapeutics for neurological and psychiatric disorders. Its primary product, Zecuity, is a transdermal patch used for acute migraine treatment. NuPathe's pipeline includes NP201, a long-acting treatment for Parkinson's disease, and NP202, a long-term solution for schizophrenia and bipolar disorder, both leveraging its biodegradable implant technology. The company, founded in 2005, operates as a subsidiary of Teva Pharmaceutical Industries Limited and is actively seeking partnerships to expand its global reach.

Portico Systems

Venture Round in 2008
Portico Systems is a provider of software applications designed for healthcare organizations, focusing on the management of complex provider networks. The company's technology enables these organizations to design, build, and service their networks effectively, facilitating value-based reimbursement. Portico Systems automates essential network management activities, including provider enrollment, credentialing, contracting, and pricing. By transforming the performance management of provider networks, the company helps to significantly reduce medical, administrative, and information technology costs for health plans.

Alverix

Series A in 2008
Alverix is a provider of point-of-care diagnostics technology that specializes in the design and manufacture of low-cost, handheld reader devices. These devices offer the precision and accuracy typically associated with laboratory instrumentation. Alverix collaborates with diagnostic and OEM manufacturers to enhance test accuracy, improve portability, and develop new assays suitable for various settings, including physician offices, laboratory outreach locations, retail clinics, and patient homes. With expertise in product design, development, and high-volume manufacturing, Alverix is at the forefront of advancing diagnostic testing from traditional laboratory environments to locations where timely results are essential for patient care.

Updater Home Services (formerly Bridgevine)

Series B in 2007
Bridgevine Inc. is a provider of a cloud-based marketing automation platform focused on customer acquisition for the digital home service and small business markets. The company's Digital Commerce Platform enables users to effectively engage with customers and prospects by presenting tailored offers across various devices, optimizing product positioning, and facilitating cross-selling opportunities. Bridgevine also offers specialized services such as Audience Optimization, which targets consumers at different stages of their shopping journey, and the Mover Media Program, a managed marketing initiative that utilizes proprietary audiences and algorithms. Additionally, the company supports a referral platform called Acquily and provides a suite of digital engagement and customer acquisition tools. Bridgevine serves a diverse clientele, including media and OTT service providers, utilities, and retailers, and is recognized for its utility and affiliate programs with major energy companies in the United States. Founded in 2003 and based in Vero Beach, Florida, Bridgevine operates as a subsidiary of Updater, Inc. following its rebranding from Broadband National, Inc. in 2006.

Cellumen

Series B in 2007
Cellumen is a pioneering company in cellular systems biology (CSB) solutions, specializing in cell-based drug discovery, early safety assessment, and discovery toxicology. The company focuses on providing accurate predictions of drug efficacy and safety, which helps reduce failure rates and lower development costs for biopharmaceutical researchers. By addressing the complexities of disease and safety, Cellumen's CSB solutions enhance the drug development process. The company collaborates with leading global organizations, including the Mayo Clinic, Hamamatsu Photonics K.K., the EPA, FDA, NIH, and major pharmaceutical companies, to advance the field of drug research and ensure the creation of effective and safe patient-targeted therapies.

Avid Radiopharmaceuticals

Series C in 2007
Avid Radiopharmaceuticals is a Philadelphia-based company focused on the development of molecular imaging agents designed to enhance the medical management of chronic diseases. Its mission centers on creating innovative imaging compounds that facilitate the early identification of pathological changes, thereby supporting earlier diagnosis and improved management of various conditions. Avid's notable product, Amyvid, is an imaging tool utilized in positron emission tomography to detect beta-amyloid plaques in the brain, which plays a crucial role in the assessment of Alzheimer's disease. Through its advancements in molecular imaging, Avid aims to contribute to the development of new therapies and improve clinical outcomes for patients suffering from significant chronic illnesses.

Authentium

Series B in 2007
Authentium, Inc. provides security software and services. It offers SafeCentral, a secure Internet that is designed to enable protected e-commerce; and Command Antivirus, an antivirus product. The company's technologies are used by software providers. Authentium, Inc. was founded in 1999 and is based in Palm Beach Gardens, Florida.

Beyond.com

Series A in 2007
Beyond.com, Inc. operates an online career network to connect job seekers and employers through career channels, and industry and regional communities. Beyond.com, it’s all about focus – and results. You identify the candidates you want to reach, and we’ll help you target them through relevant industry, local and specialty channels. Using our precise targeting abilities, we are able to deliver quality results through recruitment advertising, email marketing, mobile and social channels, and other highly effective tactics. A focused search means more qualified candidates. Get started today, with Beyond.com.

Advanced BioHealing

Series C in 2007
Advanced BioHealing is an industry leader in the science of regenerative medicine. The Company is focused on the commercialization of cell-based and tissue-engineered products. It currently markets the FDA-approved product Dermagraft®, for diabetic foot ulcers. Additionally, the Company's development pipeline includes a next-generation bioengineered tissue product which is in clinical trials. ABH is a privately held company with research & development offices in New York, NY and manufacturing operations in La Jolla, CA.

AdvantEdge Healthcare Solutions

Series A in 2006
AdvantEdge Healthcare Solutions, Inc. is a company that specializes in providing software and services for the healthcare industry, focusing on revenue cycle management and practice management. Founded in 1999 and based in Warren, New Jersey, AdvantEdge offers a range of medical billing solutions tailored to various specialties, including radiology, cardiology, anesthesia, pain management, neonatology, and internal medicine. The company serves hospitals and office-based specialty physician practices, delivering services such as billing, coding, compliance consulting, reporting, and business analytics. By enabling healthcare providers to enhance decision-making, optimize financial performance, and streamline operations, AdvantEdge aims to support its clients in navigating the complexities of healthcare management while minimizing compliance risks.

Portico Systems

Series A in 2006
Portico Systems is a provider of software applications designed for healthcare organizations, focusing on the management of complex provider networks. The company's technology enables these organizations to design, build, and service their networks effectively, facilitating value-based reimbursement. Portico Systems automates essential network management activities, including provider enrollment, credentialing, contracting, and pricing. By transforming the performance management of provider networks, the company helps to significantly reduce medical, administrative, and information technology costs for health plans.

NuPathe

Series A in 2006
NuPathe Inc., a Pennsylvania-based specialty pharmaceutical company, specializes in developing and commercializing branded therapeutics for neurological and psychiatric disorders. Its primary product, Zecuity, is a transdermal patch used for acute migraine treatment. NuPathe's pipeline includes NP201, a long-acting treatment for Parkinson's disease, and NP202, a long-term solution for schizophrenia and bipolar disorder, both leveraging its biodegradable implant technology. The company, founded in 2005, operates as a subsidiary of Teva Pharmaceutical Industries Limited and is actively seeking partnerships to expand its global reach.

Rubicor Medical

Series C in 2006
Rubicor Medical is develops and distributes technologically advanced, disposable, non-invasive, breast biopsy devices.

Authentium

Series A in 2006
Authentium, Inc. provides security software and services. It offers SafeCentral, a secure Internet that is designed to enable protected e-commerce; and Command Antivirus, an antivirus product. The company's technologies are used by software providers. Authentium, Inc. was founded in 1999 and is based in Palm Beach Gardens, Florida.

NexTone Communications

Series D in 2005
NexTone Communications, based in Rockville, Maryland, specializes in providing software solutions for Internet-based voice and data communication services. They develop products that enable efficient routing, management, and control of internet telephone calls for service providers, aiming to facilitate next-generation applications in the communications industry.
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