Safeguard Scientifics

Safeguard Scientifics, Inc., established in 1953, is a growth capital firm headquartered in Radnor, Pennsylvania, with an additional office in Weston, Massachusetts. The company specializes in providing growth capital and operational support to technology companies operating within the healthcare, financial services, and digital media sectors. Safeguard typically invests between $5 million and $25 million in growth equity financing and between $5 million and $10 million in early-stage financing. It prefers to be the largest shareholder in its portfolio companies, usually taking a 20% to 50% stake, and often seeks a Board seat. The firm focuses on companies with proprietary technology and intellectual property, and it has a history of fostering innovation and building market leaders.

Mark A. Herndon

Senior Vice President and CFO

David Luk

Principal

Mark Mitchell

Managing Director

Erik Rasmussen

Senior Vice President and Managing Director

Eric C. Salzman

CEO

Wei Zhang Ph.D

Principal and Healthcare Venture Capitalist

130 past transactions

Prognos Health

Venture Round in 2023
Prognos Health is a health tech company focused on healthcare analytics, offering a platform called prognosFACTOR. This innovative platform can quickly query billions of lab and health records from over 325 million de-identified patients, providing answers to clinically relevant healthcare questions in a fraction of the time traditionally required. Prognos Health allows clients to access HIPAA-compliant, patient-centric healthcare data through the Prognos Marketplace, facilitating a range of applications such as cohort design, patient journey studies, and health outcomes analysis. The company's clientele includes 25 of the top 30 pharmaceutical manufacturers and three of the top five health payers, highlighting its significant role in empowering precise decision-making throughout the healthcare landscape.

Syapse

Venture Round in 2022
Syapse, Inc. is a company that develops a precision medicine software platform aimed at improving cancer care through the integration and analysis of diverse clinical, molecular, treatment, and outcomes data. By leveraging real-world evidence, Syapse enables healthcare organizations to collaborate effectively, providing comprehensive patient insights that inform clinical decisions. Its primary offering, the Syapse Learning Health Network, serves as a global data-sharing network that supports oncologists and life sciences collaborators with actionable insights derived from real-world data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse works to enhance precision medicine programs and drive impactful outcomes for cancer patients. The company has also established a strategic partnership with Pfizer to further its mission in the field of precision oncology.

Moxe

Series B in 2022
Moxe Health specializes in facilitating the bi-directional exchange of clinical data between health plans and provider systems through its innovative clinical data integration platform. The company offers a range of services including risk adjustment, claims denial management, clinical summaries, administrative notifications, and care gap management. By creating an interactive network, Moxe ensures that health systems and health plans can share medical records and crucial patient insights quickly and efficiently, without disrupting clinicians' existing workflows. The platform supports the transition to value-based care by providing automated solutions that enhance access to essential information, allowing organizations to leverage their investments in population health and analytics effectively. Moxe's commitment to neutrality in data connectivity further enhances its value proposition in the healthcare industry.

Moxe

Venture Round in 2021
Moxe Health specializes in facilitating the bi-directional exchange of clinical data between health plans and provider systems through its innovative clinical data integration platform. The company offers a range of services including risk adjustment, claims denial management, clinical summaries, administrative notifications, and care gap management. By creating an interactive network, Moxe ensures that health systems and health plans can share medical records and crucial patient insights quickly and efficiently, without disrupting clinicians' existing workflows. The platform supports the transition to value-based care by providing automated solutions that enhance access to essential information, allowing organizations to leverage their investments in population health and analytics effectively. Moxe's commitment to neutrality in data connectivity further enhances its value proposition in the healthcare industry.

Syapse

Series F in 2020
Syapse, Inc. is a company that develops a precision medicine software platform aimed at improving cancer care through the integration and analysis of diverse clinical, molecular, treatment, and outcomes data. By leveraging real-world evidence, Syapse enables healthcare organizations to collaborate effectively, providing comprehensive patient insights that inform clinical decisions. Its primary offering, the Syapse Learning Health Network, serves as a global data-sharing network that supports oncologists and life sciences collaborators with actionable insights derived from real-world data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse works to enhance precision medicine programs and drive impactful outcomes for cancer patients. The company has also established a strategic partnership with Pfizer to further its mission in the field of precision oncology.

Trice Medical

Series C in 2019
Trice Medical, Inc. is a company that specializes in the development of innovative orthopedic diagnostic devices featuring integrated camera-enabled and needle-based technologies. Founded in 2011 and headquartered in Malvern, Pennsylvania, Trice Medical aims to enhance patient care by providing immediate and accurate diagnostic solutions that can be administered in a physician's office. Their products facilitate minimally invasive procedures that are designed to be painless, cosmetically undetectable, and of surgical grade quality. By optimizing the diagnostic process, Trice Medical seeks to eliminate inaccuracies associated with traditional indirect modalities, thereby reducing costs for the healthcare system while improving the overall patient experience.

InfoBionic

Venture Round in 2018
InfoBionic, Inc., founded in 2011 and based in Lowell, Massachusetts, specializes in remote patient monitoring and cardiac diagnostic services through its cloud-based platform, MoMe™. The MoMe System is designed to enhance the detection of cardiac arrhythmias, allowing healthcare providers to access vital patient data anytime and anywhere. By replicating in-hospital telemetry data, the platform streams continuous electrocardiogram, respiration, and motion data to the cloud for real-time analysis. This innovation aims to improve clinical efficiency and patient care, enabling physicians to monitor and treat cardiac complications effectively.

Zipnosis

Series B in 2018
Zipnosis, Inc. is a healthcare company based in Minneapolis, Minnesota, that specializes in virtual care solutions. Founded in 2008, the company operates a platform that connects patients with clinicians through phone and video interviews, facilitating online diagnosis and triage. Zipnosis offers a unique service called ZipTicket, which acts as a healthcare boarding pass, allowing patients to access clinics for in-person assessments or lab tests when necessary. The platform is designed to enhance patient choice and convenience while improving efficiency for healthcare providers. Through its innovative approach, Zipnosis aims to expand access to immediate care and improve clinical outcomes for health organizations.

meQuilibrium

Series C in 2018
meQuilibrium is a digital health company that provides online stress management solutions for individuals and employees. Its clinically validated platform leverages behavioral psychology, neuroscience, and analytics to deliver personalized insights and training programs aimed at enhancing resilience, improving mental well-being, and boosting overall business performance by increasing workforce agility and emotional control.

Propeller Health

Series D in 2018
Propeller Health is a digital health platform focused on improving the management of chronic respiratory diseases such as asthma and COPD. The company provides a mobile application and sensors that attach to inhalers, enabling users to track their medication usage, triggers, and symptoms. This data is stored securely in a cloud-based infrastructure and facilitates personalized feedback and education for users. The platform also allows users to set medication reminders and alerts, as well as share their health data with physicians and family members. Propeller Health collaborates with various healthcare organizations and has received multiple awards for innovation in the field. Founded by David Van Sickle, Greg Tracy, and Mark Gehring, the company operates from Wisconsin, United States.

Prognos Health

Series C in 2017
Prognos Health is a health tech company focused on healthcare analytics, offering a platform called prognosFACTOR. This innovative platform can quickly query billions of lab and health records from over 325 million de-identified patients, providing answers to clinically relevant healthcare questions in a fraction of the time traditionally required. Prognos Health allows clients to access HIPAA-compliant, patient-centric healthcare data through the Prognos Marketplace, facilitating a range of applications such as cohort design, patient journey studies, and health outcomes analysis. The company's clientele includes 25 of the top 30 pharmaceutical manufacturers and three of the top five health payers, highlighting its significant role in empowering precise decision-making throughout the healthcare landscape.

Syapse

Series D in 2017
Syapse, Inc. is a company that develops a precision medicine software platform aimed at improving cancer care through the integration and analysis of diverse clinical, molecular, treatment, and outcomes data. By leveraging real-world evidence, Syapse enables healthcare organizations to collaborate effectively, providing comprehensive patient insights that inform clinical decisions. Its primary offering, the Syapse Learning Health Network, serves as a global data-sharing network that supports oncologists and life sciences collaborators with actionable insights derived from real-world data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse works to enhance precision medicine programs and drive impactful outcomes for cancer patients. The company has also established a strategic partnership with Pfizer to further its mission in the field of precision oncology.

QuanticMind

Series B in 2017
QuanticMind Inc. develops a predictive advertising management software that focuses on optimizing paid search, social media, display, and mobile advertising. Founded in 2011 and based in Redwood City, California, the company has established itself as a pioneer in the field by utilizing advanced technologies such as machine learning, distributed cloud computing, and in-memory processing. QuanticMind's platform integrates cross-channel and third-party data to provide actionable insights for advertisers, enabling them to make informed decisions and maximize their advertising performance. Additionally, QuanticMind offers services including data quality assurance, technical support, and training to enhance user experience and effectiveness. The company serves a global community of data-driven marketers who rely on its innovative solutions to improve their advertising strategies.

Trice Medical

Series C in 2017
Trice Medical, Inc. is a company that specializes in the development of innovative orthopedic diagnostic devices featuring integrated camera-enabled and needle-based technologies. Founded in 2011 and headquartered in Malvern, Pennsylvania, Trice Medical aims to enhance patient care by providing immediate and accurate diagnostic solutions that can be administered in a physician's office. Their products facilitate minimally invasive procedures that are designed to be painless, cosmetically undetectable, and of surgical grade quality. By optimizing the diagnostic process, Trice Medical seeks to eliminate inaccuracies associated with traditional indirect modalities, thereby reducing costs for the healthcare system while improving the overall patient experience.

T-REX

Series B in 2017
T-REX Group, Inc. develops an enterprise Software-as-a-Service platform tailored for the finance, renewables, and technology sectors. The platform, known as T-REX Analytics, provides tools for analyzing acquisitions and sales of solar assets, structuring renewable energy-backed deals, and managing ongoing portfolios. It enables users to assess production and credit risk parameters impacting cash flows, such as power production and operating expenses. The analytics capabilities allow for the structuring of customized debt tranches, the creation of capital structures for securitization, and the valuation of cash flows based on user-defined assumptions. By enhancing transparency and efficiency in complex asset classes, T-REX aims to unlock significant investment opportunities, making it easier for industry participants to invest in, securitize, and manage portfolios of diverse assets. Founded in 2012, T-REX is headquartered in New York, with additional offices in San Francisco and Tel Aviv.

CloudMine

Series A in 2017
CloudMine is a mobile backend-as-a-service (mBaaS) provider that focuses on enhancing healthcare mobility and patient health. The company offers a platform that facilitates object-based data storage and file storage, along with capabilities for sending push notifications and messages, thereby improving communication with users. By streamlining the development process, CloudMine enables healthcare and life science organizations to efficiently operationalize data through application development, analytics, and workflows. The platform is designed to support the creation of secure, interoperable, and scalable healthcare applications, significantly reducing development time and costs while eliminating the need for ongoing maintenance and management of mobile applications. Its mobile-optimized infrastructure and suite of prefabricated web services accelerate app development by up to 70%, standardizing mobility tools across various business units for improved efficiency.

VitalTrax

Seed Round in 2017
VitalTrax connects patients with clinical trials with its cloud-based clinical trial network. VitalTrax offers Wing, a solution that simplifies clinical trials enrollment. Wing is a clinical trial network that provides innovative ways for people to easily seek optional treatments for themselves or people that they love and play an important role in helping develop new ways to fight diseases.

Velano Vascular

Series B in 2017
Velano Vascular, Inc. is a medical device company based in San Francisco, California, established in 2011. The company specializes in the development of needle-free vascular access devices, particularly its FDA-approved PIVO device. This innovative, single-use, and sterile device allows for blood collection from indwelling peripheral IV lines, significantly reducing the need for traditional needle sticks and central line access. Velano Vascular aims to enhance patient care by providing a painless and efficient blood draw option, thereby improving the experience for hospital inpatients while also offering a safer practice for healthcare providers. Additionally, the PIVO device presents a financially responsible alternative for health systems, addressing the challenges associated with conventional vascular access methods.

Cognitive Operational Systems

Seed Round in 2017
Cognitive Operational Systems, LLC, based in Philadelphia, Pennsylvania, specializes in developing inventory management solutions for the retail sector through the use of robotics, artificial intelligence, and computer vision. Founded in 2012, the company’s technology enables robots to efficiently navigate retail environments, managing inventory, ensuring compliance with planograms and promotions, and providing indoor localization and navigation. Additionally, it offers mapping capabilities that detail store layouts and architecture. By leveraging university research, Cognitive Operational Systems aims to bridge the gap between academic advancements and practical applications in the fields of artificial intelligence and machine perception.

Spongecell

Venture Round in 2016
Spongecell, Inc. is an advertising technology company based in New York that specializes in creating and managing personalized digital advertisements. Founded in 2006, the company transforms traditional banner ads into interactive formats that can incorporate video, social media, and other engaging features. Its Creative Management Platform enables brands to develop unique ad experiences across display, mobile, and video platforms, leveraging intelligent data integrations and decision-making tools. By streamlining the creative process, Spongecell empowers advertisers and their agencies to execute effective online campaigns that enhance brand engagement and drive performance. The company has received recognition for its innovative approach to programmatic advertising and operates as a subsidiary of Simplicity Marketing Ltd.

Brickwork

Series A in 2016
Brickwork is a retail technology company that offers a Software as a Service (SaaS) platform designed to enhance the pre-visit experience for customers of major brands and retailers. Founded in 2013 and headquartered in New York, Brickwork's platform provides accurate store information, access to events and promotions, and personal assistance, ensuring customers are well-informed before visiting stores. The solution aims to bridge the gap between online and in-store shopping by managing critical store data and content, which helps brands improve decision-making and overall customer experience. Additionally, Brickwork's innovative approach includes measuring Digital-to-Store Conversion, allowing marketers and store teams to drive traffic, engagement, and increase sales.

Propeller Health

Series C in 2016
Propeller Health is a digital health platform focused on improving the management of chronic respiratory diseases such as asthma and COPD. The company provides a mobile application and sensors that attach to inhalers, enabling users to track their medication usage, triggers, and symptoms. This data is stored securely in a cloud-based infrastructure and facilitates personalized feedback and education for users. The platform also allows users to set medication reminders and alerts, as well as share their health data with physicians and family members. Propeller Health collaborates with various healthcare organizations and has received multiple awards for innovation in the field. Founded by David Van Sickle, Greg Tracy, and Mark Gehring, the company operates from Wisconsin, United States.

Moxe

Series A in 2016
Moxe Health specializes in facilitating the bi-directional exchange of clinical data between health plans and provider systems through its innovative clinical data integration platform. The company offers a range of services including risk adjustment, claims denial management, clinical summaries, administrative notifications, and care gap management. By creating an interactive network, Moxe ensures that health systems and health plans can share medical records and crucial patient insights quickly and efficiently, without disrupting clinicians' existing workflows. The platform supports the transition to value-based care by providing automated solutions that enhance access to essential information, allowing organizations to leverage their investments in population health and analytics effectively. Moxe's commitment to neutrality in data connectivity further enhances its value proposition in the healthcare industry.

Medcrypt

Seed Round in 2016
MedCrypt Inc. is a cybersecurity company specializing in the protection of medical devices. Founded in 2016 and based in Encinitas, California, MedCrypt provides data security solutions for a wide range of medical devices, including implantable devices like pacemakers and various surgical robots. The company's platform offers data security as a service to medical device original equipment manufacturers (OEMs), enabling them to implement essential security features quickly and efficiently. These features include user authentication, data encryption, and transaction monitoring to detect potential malicious behavior. By integrating security capabilities into medical devices with minimal code, MedCrypt allows engineers to focus on developing innovative clinical functionalities while ensuring the safety and integrity of device operations.

InfoBionic

Series B in 2016
InfoBionic, Inc., founded in 2011 and based in Lowell, Massachusetts, specializes in remote patient monitoring and cardiac diagnostic services through its cloud-based platform, MoMe™. The MoMe System is designed to enhance the detection of cardiac arrhythmias, allowing healthcare providers to access vital patient data anytime and anywhere. By replicating in-hospital telemetry data, the platform streams continuous electrocardiogram, respiration, and motion data to the cloud for real-time analysis. This innovation aims to improve clinical efficiency and patient care, enabling physicians to monitor and treat cardiac complications effectively.

Aktana

Series B in 2016
Aktana Inc. is a technology company that specializes in AI-enabled marketing decision support software tailored for the life sciences sector. Founded in 2008 and headquartered in San Francisco, Aktana develops a platform that utilizes machine learning algorithms to assist sales and marketing teams in optimizing their engagement with healthcare professionals. Its key offerings include the Contextual Intelligence Engine, which allows executives to simulate various marketing strategies, and the Decision Support Engine, which analyzes diverse data sources to provide actionable insights directly within the representative’s existing CRM workflows. By focusing exclusively on the life sciences market, Aktana delivers data-driven suggestions that enhance multichannel marketing initiatives and improve overall campaign effectiveness. The company supports over 100 brands, including more than half of the top 20 pharmaceutical companies globally, helping them to maximize revenue and utilize data investments efficiently. Additionally, Aktana has offices in several international locations, including Tokyo, Shanghai, and Barcelona.

Noble.MD

Seed Round in 2016
Noble.MD is a healthcare technology company based in Bryn Mawr, Pennsylvania, founded in 2012. The company develops Theo, a digital healthcare advisory platform designed to assist patients in identifying health and behavioral risks. The platform actively engages patients by providing programs and interventions to help them manage these risks. By capturing essential patient data at the time of care, Noble.MD facilitates value-based reimbursement and aligns the interests of providers and payers, enhancing the processes of risk identification, coding, and management.

Transactis

Series E in 2016
Transactis, Inc. is a New York-based company specializing in Software-as-a-Service solutions for electronic bill presentment and payment. Established in 2001, Transactis enables businesses to transition from traditional paper-based billing to efficient digital alternatives. Its primary offerings include BillerIQ, a cloud platform for delivering electronic bills and accepting online, phone, and mobile payments, and DocumentIQ, a digital document management system for transforming and archiving documents. The company serves a diverse array of industries, including financial services, healthcare, utilities, and retail, among others. Operating solely through a network of resellers, which include financial institutions and technology companies, Transactis provides white-label SaaS solutions along with substantial sales, marketing, and technical support to empower its partners. The company adheres to rigorous regulatory standards, ensuring compliance with regulations such as HIPAA and PCI Level 1.

Velano Vascular

Series A in 2016
Velano Vascular, Inc. is a medical device company based in San Francisco, California, established in 2011. The company specializes in the development of needle-free vascular access devices, particularly its FDA-approved PIVO device. This innovative, single-use, and sterile device allows for blood collection from indwelling peripheral IV lines, significantly reducing the need for traditional needle sticks and central line access. Velano Vascular aims to enhance patient care by providing a painless and efficient blood draw option, thereby improving the experience for hospital inpatients while also offering a safer practice for healthcare providers. Additionally, the PIVO device presents a financially responsible alternative for health systems, addressing the challenges associated with conventional vascular access methods.

Syapse

Series C in 2016
Syapse, Inc. is a company that develops a precision medicine software platform aimed at improving cancer care through the integration and analysis of diverse clinical, molecular, treatment, and outcomes data. By leveraging real-world evidence, Syapse enables healthcare organizations to collaborate effectively, providing comprehensive patient insights that inform clinical decisions. Its primary offering, the Syapse Learning Health Network, serves as a global data-sharing network that supports oncologists and life sciences collaborators with actionable insights derived from real-world data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse works to enhance precision medicine programs and drive impactful outcomes for cancer patients. The company has also established a strategic partnership with Pfizer to further its mission in the field of precision oncology.

Zipnosis

Series A in 2016
Zipnosis, Inc. is a healthcare company based in Minneapolis, Minnesota, that specializes in virtual care solutions. Founded in 2008, the company operates a platform that connects patients with clinicians through phone and video interviews, facilitating online diagnosis and triage. Zipnosis offers a unique service called ZipTicket, which acts as a healthcare boarding pass, allowing patients to access clinics for in-person assessments or lab tests when necessary. The platform is designed to enhance patient choice and convenience while improving efficiency for healthcare providers. Through its innovative approach, Zipnosis aims to expand access to immediate care and improve clinical outcomes for health organizations.

Cask

Series B in 2015
Cask is an open-source software company based in Palo Alto, California, that specializes in simplifying the development and management of big data solutions. The company offers a unified integration platform that significantly reduces the time required to deploy data applications and data lakes by up to 80%. Cask's platform combines data integration and application development capabilities, allowing customers to accelerate their development processes in both public and private cloud environments. It is supported by notable investors, including Battery Ventures, Andreessen Horowitz, and Ignition Partners.

QuanticMind

Series A in 2015
QuanticMind Inc. develops a predictive advertising management software that focuses on optimizing paid search, social media, display, and mobile advertising. Founded in 2011 and based in Redwood City, California, the company has established itself as a pioneer in the field by utilizing advanced technologies such as machine learning, distributed cloud computing, and in-memory processing. QuanticMind's platform integrates cross-channel and third-party data to provide actionable insights for advertisers, enabling them to make informed decisions and maximize their advertising performance. Additionally, QuanticMind offers services including data quality assurance, technical support, and training to enhance user experience and effectiveness. The company serves a global community of data-driven marketers who rely on its innovative solutions to improve their advertising strategies.

Sonobi

Series A in 2015
Sonobi, Inc. is an advertising technology company based in Winter Park, Florida, founded in 2011. It offers a platform that connects publishers, advertisers, and media agencies, facilitating the marketing and positioning of advertising opportunities. By utilizing user-centric technology and intelligent data, Sonobi enables clients to drive results and achieve their business goals through more effective advertising strategies. The platform includes tools for both buy and sell sides of the advertising market, allowing users to identify, deliver, and manage advertising opportunities efficiently. Additionally, Sonobi provides a Consent Management Platform, designed to help publishers ensure compliance with privacy regulations while maintaining transparent consent processes. Overall, Sonobi aims to create a fair and equitable media marketplace, fostering better connections between brands and individuals.

Apprenda

Series D in 2015
Apprenda is a developer of a cloud-based enterprise platform that enhances enterprise software development. Established in 2007 and headquartered in Troy, New York, the company specializes in creating modern application platforms suitable for both cloud-native and traditional workloads. Apprenda's offerings enable enterprise IT to build a Kubernetes-enabled shared service on various infrastructures, facilitating collaboration among developers across different business units. By streamlining the software delivery process, Apprenda aims to transform IT into a dynamic engine of growth for organizations, drawing on over a decade of insights from enterprise customers.

Pneuron

Series B in 2015
Pneuron offers a business platform designed to streamline the development, deployment, and management of products, analytics, and operational practices for enterprises. By utilizing its Distributed Platform, Pneuron enables organizations to connect data, applications, and processes directly with their existing systems, eliminating the need for intermediary databases and reducing integration costs. This platform facilitates the management of the entire business solution lifecycle from a single interface, addressing challenges related to complexity, time, and cost. As a result, businesses experience enhanced productivity, improved engagement with their expertise, and lower costs, allowing them to focus on driving innovation and realizing business value.

Clutch

Series B in 2015
Clutch serves as a customer marketing platform for business-to-consumer brands. It provides traditional marketing CRM, loyalty, gift card, mobile, email, and direct mail solutions. The company was created to help businesses succeed in an evolving marketing landscape. Since 2012, they have continued to grow their platform into an innovative, data-centric marketing solution with one focus that empowering brands with the best technology so that they can identify, understand and motivate their customers.

Full Measure Education

Series B in 2015
Full Measure Education, Inc. is a Washington, D.C.-based company that develops a mobile engagement platform aimed at enhancing the student experience in higher education. Founded in 2013, the company provides a suite of tools designed to assist students in managing their administrative needs while also addressing retention challenges faced by colleges and universities. Its platform includes features such as messaging inboxes, custom auto-responses, campaign management, and data reporting, all of which facilitate effective communication and support throughout the student lifecycle, from admission to graduation. Drawing on extensive experience from over 10 million student help desk interactions across more than 850 institutions, Full Measure Education aims to improve key metrics such as retention rates, enrollment growth, and operational efficiency for educational institutions.

meQuilibrium

Series B in 2015
meQuilibrium is a digital health company that provides online stress management solutions for individuals and employees. Its clinically validated platform leverages behavioral psychology, neuroscience, and analytics to deliver personalized insights and training programs aimed at enhancing resilience, improving mental well-being, and boosting overall business performance by increasing workforce agility and emotional control.

CloudMine

Series A in 2015
CloudMine is a mobile backend-as-a-service (mBaaS) provider that focuses on enhancing healthcare mobility and patient health. The company offers a platform that facilitates object-based data storage and file storage, along with capabilities for sending push notifications and messages, thereby improving communication with users. By streamlining the development process, CloudMine enables healthcare and life science organizations to efficiently operationalize data through application development, analytics, and workflows. The platform is designed to support the creation of secure, interoperable, and scalable healthcare applications, significantly reducing development time and costs while eliminating the need for ongoing maintenance and management of mobile applications. Its mobile-optimized infrastructure and suite of prefabricated web services accelerate app development by up to 70%, standardizing mobility tools across various business units for improved efficiency.

Aventura Software

Series C in 2015
Aventura intelligently orchestrates assets, people, and systems to deliver the right information at the right time based on location and credentials. It locates and re-assigns the closest online printer and uniquely manages print routing to make it easier to detect and fix printing failures. Aventura was formed in 2007 and headquartered in Denver, Colorado.

Velano Vascular

Series A in 2015
Velano Vascular, Inc. is a medical device company based in San Francisco, California, established in 2011. The company specializes in the development of needle-free vascular access devices, particularly its FDA-approved PIVO device. This innovative, single-use, and sterile device allows for blood collection from indwelling peripheral IV lines, significantly reducing the need for traditional needle sticks and central line access. Velano Vascular aims to enhance patient care by providing a painless and efficient blood draw option, thereby improving the experience for hospital inpatients while also offering a safer practice for healthcare providers. Additionally, the PIVO device presents a financially responsible alternative for health systems, addressing the challenges associated with conventional vascular access methods.

Trice Medical

Series B in 2015
Trice Medical, Inc. is a company that specializes in the development of innovative orthopedic diagnostic devices featuring integrated camera-enabled and needle-based technologies. Founded in 2011 and headquartered in Malvern, Pennsylvania, Trice Medical aims to enhance patient care by providing immediate and accurate diagnostic solutions that can be administered in a physician's office. Their products facilitate minimally invasive procedures that are designed to be painless, cosmetically undetectable, and of surgical grade quality. By optimizing the diagnostic process, Trice Medical seeks to eliminate inaccuracies associated with traditional indirect modalities, thereby reducing costs for the healthcare system while improving the overall patient experience.

Propeller Health

Series B in 2014
Propeller Health is a digital health platform focused on improving the management of chronic respiratory diseases such as asthma and COPD. The company provides a mobile application and sensors that attach to inhalers, enabling users to track their medication usage, triggers, and symptoms. This data is stored securely in a cloud-based infrastructure and facilitates personalized feedback and education for users. The platform also allows users to set medication reminders and alerts, as well as share their health data with physicians and family members. Propeller Health collaborates with various healthcare organizations and has received multiple awards for innovation in the field. Founded by David Van Sickle, Greg Tracy, and Mark Gehring, the company operates from Wisconsin, United States.

Transactis

Series D in 2014
Transactis, Inc. is a New York-based company specializing in Software-as-a-Service solutions for electronic bill presentment and payment. Established in 2001, Transactis enables businesses to transition from traditional paper-based billing to efficient digital alternatives. Its primary offerings include BillerIQ, a cloud platform for delivering electronic bills and accepting online, phone, and mobile payments, and DocumentIQ, a digital document management system for transforming and archiving documents. The company serves a diverse array of industries, including financial services, healthcare, utilities, and retail, among others. Operating solely through a network of resellers, which include financial institutions and technology companies, Transactis provides white-label SaaS solutions along with substantial sales, marketing, and technical support to empower its partners. The company adheres to rigorous regulatory standards, ensuring compliance with regulations such as HIPAA and PCI Level 1.

WebLinc

Series A in 2014
WebLinc is a provider of ecommerce solutions, offering the Workarea Commerce Cloud platform and the Orderbot order management system. These modern technologies are designed to support global, omnichannel commerce operations, helping retailers enhance their competitive edge. WebLinc serves a diverse range of successful retail and B2B clients, including well-known brands such as URBN's BHLDN and Terrain, Sanrio, The Reformation, STAPLES Canada, Buzzfeed, Live Nation, Woodcraft Supplies, and The Bouqs. The company's focus on agility and strategic expertise enables its clients to thrive in the rapidly evolving online retail landscape.

Trice Medical

Series B in 2014
Trice Medical, Inc. is a company that specializes in the development of innovative orthopedic diagnostic devices featuring integrated camera-enabled and needle-based technologies. Founded in 2011 and headquartered in Malvern, Pennsylvania, Trice Medical aims to enhance patient care by providing immediate and accurate diagnostic solutions that can be administered in a physician's office. Their products facilitate minimally invasive procedures that are designed to be painless, cosmetically undetectable, and of surgical grade quality. By optimizing the diagnostic process, Trice Medical seeks to eliminate inaccuracies associated with traditional indirect modalities, thereby reducing costs for the healthcare system while improving the overall patient experience.

Syapse

Series B in 2014
Syapse, Inc. is a company that develops a precision medicine software platform aimed at improving cancer care through the integration and analysis of diverse clinical, molecular, treatment, and outcomes data. By leveraging real-world evidence, Syapse enables healthcare organizations to collaborate effectively, providing comprehensive patient insights that inform clinical decisions. Its primary offering, the Syapse Learning Health Network, serves as a global data-sharing network that supports oncologists and life sciences collaborators with actionable insights derived from real-world data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse works to enhance precision medicine programs and drive impactful outcomes for cancer patients. The company has also established a strategic partnership with Pfizer to further its mission in the field of precision oncology.

Lumesis

Series B in 2014
Lumesis, Inc. is a financial technology company based in Stamford, Connecticut, specializing in Software-as-a-Service solutions for the municipal marketplace. Founded in 2010, the company operates under the DIVER brand, providing a range of regulatory and data solutions tailored to the needs of U.S. banks, broker/dealers, asset managers, insurance companies, hedge funds, and other financial professionals. Its flagship product, DIVER Analytics, offers access to extensive datasets and analytical tools to address challenges such as stale financials and fiscal uncertainty. Additionally, DIVER Advisor supports clients in meeting regulatory requirements related to time-of-trade disclosure and portfolio management. Lumesis also provides DIVER Data Services, which streamlines data aggregation and delivery, allowing clients to access customized datasets efficiently. Through these solutions, Lumesis aims to enhance business efficiency and decision-making within the municipal bond market.

MediaMath

Series C in 2014
MediaMath, Inc. is a digital advertising technology company that specializes in providing solutions for advertisers globally. Founded in 2007 and headquartered in New York, the company offers its TerminalOne platform, which facilitates data activation, automated execution, and optimization of advertising interactions across various media channels. MediaMath's programmatic marketing platform enhances customer engagement by utilizing predictive audience targeting and machine learning to ensure relevant messaging. In addition to its technology offerings, the company provides professional services that include programmatic strategy, analytics, technology support, and advertising operations, as well as training and certification programs in digital marketing. MediaMath operates additional offices in several cities across the United States and internationally, including London, Madrid, Berlin, Singapore, Tokyo, Sao Paulo, Sydney, Melbourne, and Bengaluru.

Sotera Wireless

Venture Round in 2014
Sotera Wireless, Inc. is a medical device company dedicated to the development, marketing and sale of a new generation of comprehensive vital signs monitoring. Sotera’s mission is to improve patient safety by empowering clinicians to detect early signs of deterioration in virtually any care setting and enable early intervention and rapid response, all without limiting the patient’s freedom of movement.

InfoBionic

Series B in 2014
InfoBionic, Inc., founded in 2011 and based in Lowell, Massachusetts, specializes in remote patient monitoring and cardiac diagnostic services through its cloud-based platform, MoMe™. The MoMe System is designed to enhance the detection of cardiac arrhythmias, allowing healthcare providers to access vital patient data anytime and anywhere. By replicating in-hospital telemetry data, the platform streams continuous electrocardiogram, respiration, and motion data to the cloud for real-time analysis. This innovation aims to improve clinical efficiency and patient care, enabling physicians to monitor and treat cardiac complications effectively.

Hoopla

Series B in 2014
Hoopla is the new way to win for sales, marketing and customer service teams. Hoopla’s team performance software combines modern game mechanics, data analytics and broadcast-quality video in a powerfully simple application that makes it easy for front-line managers to motivate team performance and score more wins. Using Hoopla, managers can quickly create contests, competitions and leaderboards around any CRM metric, and broadcast live performance updates to TV, web and mobile screens throughout the company. Hoopla's Sales Motivation solutions engage the entire company in an exciting, play-to-win culture that delivers measurable gains in team productivity and performance. Founded in 2010, Hoopla is headquartered in Silicon Valley.

Apprenda

Series C in 2013
Apprenda is a developer of a cloud-based enterprise platform that enhances enterprise software development. Established in 2007 and headquartered in Troy, New York, the company specializes in creating modern application platforms suitable for both cloud-native and traditional workloads. Apprenda's offerings enable enterprise IT to build a Kubernetes-enabled shared service on various infrastructures, facilitating collaboration among developers across different business units. By streamlining the software delivery process, Apprenda aims to transform IT into a dynamic engine of growth for organizations, drawing on over a decade of insights from enterprise customers.

Dabo Health

Series A in 2013
Dabo Health provides the healthcare community a free platform to view and track improvement in key performance metrics, to collaborate across hospitals and healthcare systems, and to identify and share evidence based best practices in order to save lives. In the era of Big Data, we enlighten individuals, organizations and industries and empower fundamental change at all levels. By combining human-powered insights with raw, objective data, we inform confident decisions and drive efficiencies. Ours is a system that rewards collaboration with innovative ideas that are integral to the progression of humanity. We call it “The Power of Collective Intelligence.” We channel this shared knowledge of passionate professionals to empower progress.

Clutch

Venture Round in 2013
Clutch serves as a customer marketing platform for business-to-consumer brands. It provides traditional marketing CRM, loyalty, gift card, mobile, email, and direct mail solutions. The company was created to help businesses succeed in an evolving marketing landscape. Since 2012, they have continued to grow their platform into an innovative, data-centric marketing solution with one focus that empowering brands with the best technology so that they can identify, understand and motivate their customers.

Quantia

Series B in 2013
QuantiaMD operates as a prominent online community and collaboration platform designed specifically for physicians, boasting a membership of 160,000 doctors who exchange real-life clinical experiences swiftly and extensively. This platform enables healthcare organizations to effectively engage with physicians, aligning them towards common objectives that enhance the quality of care provided. By utilizing a combination of social media elements, gamification, and engagement science, QuantiaMD facilitates seamless communication between healthcare companies and physicians. The platform is designed to be user-friendly, secure, and fully mobile, catering to the contemporary needs of medical professionals.

Prognos Health

Series B in 2013
Prognos Health is a health tech company focused on healthcare analytics, offering a platform called prognosFACTOR. This innovative platform can quickly query billions of lab and health records from over 325 million de-identified patients, providing answers to clinically relevant healthcare questions in a fraction of the time traditionally required. Prognos Health allows clients to access HIPAA-compliant, patient-centric healthcare data through the Prognos Marketplace, facilitating a range of applications such as cohort design, patient journey studies, and health outcomes analysis. The company's clientele includes 25 of the top 30 pharmaceutical manufacturers and three of the top five health payers, highlighting its significant role in empowering precise decision-making throughout the healthcare landscape.

Pneuron

Series B in 2013
Pneuron offers a business platform designed to streamline the development, deployment, and management of products, analytics, and operational practices for enterprises. By utilizing its Distributed Platform, Pneuron enables organizations to connect data, applications, and processes directly with their existing systems, eliminating the need for intermediary databases and reducing integration costs. This platform facilitates the management of the entire business solution lifecycle from a single interface, addressing challenges related to complexity, time, and cost. As a result, businesses experience enhanced productivity, improved engagement with their expertise, and lower costs, allowing them to focus on driving innovation and realizing business value.

Sotera Wireless

Series D in 2013
Sotera Wireless, Inc. is a medical device company dedicated to the development, marketing and sale of a new generation of comprehensive vital signs monitoring. Sotera’s mission is to improve patient safety by empowering clinicians to detect early signs of deterioration in virtually any care setting and enable early intervention and rapid response, all without limiting the patient’s freedom of movement.

Crescendo Bioscience

Series D in 2013
Crescendo Bioscience, Inc. is a molecular diagnostics company based in South San Francisco, California, that specializes in developing quantitative diagnostic tools for rheumatologists managing autoimmune and inflammatory diseases. Founded in 2002, the company focuses on creating and commercializing blood tests, notably Vectra DA, a standardized multi-biomarker test that assesses disease activity in rheumatoid arthritis. These diagnostic and prognostic tools provide physicians with crucial clinical insights, facilitating therapy selection, monitoring, and overall management of patients with rheumatoid arthritis. By offering objective molecular tests and disease information services, Crescendo Bioscience aims to improve patient outcomes in the field of rheumatology.

AppFirst

Series B in 2012
AppFirst’s is a patented technology that provides a solution for collecting every event across web-scale applications, regardless of the infrastructure type or programming language. With microsecond visibility into all the applications and supporting resources across their shared infrastructure, IT Operations can now deterministically get to the root cause, effectively footprint applications to determine exactly what resources that application requires, and proactively identify when their applications become wobbly. Those responsible for the infrastructure finally have a way to continuously understand the performance of every application running on the shared-resources they own.

Hoopla

Series A in 2012
Hoopla is the new way to win for sales, marketing and customer service teams. Hoopla’s team performance software combines modern game mechanics, data analytics and broadcast-quality video in a powerfully simple application that makes it easy for front-line managers to motivate team performance and score more wins. Using Hoopla, managers can quickly create contests, competitions and leaderboards around any CRM metric, and broadcast live performance updates to TV, web and mobile screens throughout the company. Hoopla's Sales Motivation solutions engage the entire company in an exciting, play-to-win culture that delivers measurable gains in team productivity and performance. Founded in 2010, Hoopla is headquartered in Silicon Valley.

Good Start Genetics

Series B in 2012
Good Start Genetics, Inc. is a molecular diagnostics company based in Cambridge, Massachusetts, focused on genetic screening for inherited diseases. Founded in 2007, the company aims to transform reproductive medicine by providing physicians and patients with actionable insights into inherited genetic disorders. Good Start Genetics offers a range of services, including EmbryVu, a preimplantation genetic screening test designed to enhance in vitro fertilization outcomes by identifying suitable embryos for implantation. The company employs advanced next-generation DNA sequencing technology, along with other established genetic screening methods, to deliver high carrier detection rates. Additionally, through its GoodStart Select program, it provides a comprehensive menu of genetic carrier screening tests for both known and novel mutations, all supported by a commitment to customer care and genetic counseling. As of August 2017, Good Start Genetics operates as a subsidiary of Invitae Corporation.

Lumesis

Series A in 2012
Lumesis, Inc. is a financial technology company based in Stamford, Connecticut, specializing in Software-as-a-Service solutions for the municipal marketplace. Founded in 2010, the company operates under the DIVER brand, providing a range of regulatory and data solutions tailored to the needs of U.S. banks, broker/dealers, asset managers, insurance companies, hedge funds, and other financial professionals. Its flagship product, DIVER Analytics, offers access to extensive datasets and analytical tools to address challenges such as stale financials and fiscal uncertainty. Additionally, DIVER Advisor supports clients in meeting regulatory requirements related to time-of-trade disclosure and portfolio management. Lumesis also provides DIVER Data Services, which streamlines data aggregation and delivery, allowing clients to access customized datasets efficiently. Through these solutions, Lumesis aims to enhance business efficiency and decision-making within the municipal bond market.

Spongecell

Series B in 2012
Spongecell, Inc. is an advertising technology company based in New York that specializes in creating and managing personalized digital advertisements. Founded in 2006, the company transforms traditional banner ads into interactive formats that can incorporate video, social media, and other engaging features. Its Creative Management Platform enables brands to develop unique ad experiences across display, mobile, and video platforms, leveraging intelligent data integrations and decision-making tools. By streamlining the creative process, Spongecell empowers advertisers and their agencies to execute effective online campaigns that enhance brand engagement and drive performance. The company has received recognition for its innovative approach to programmatic advertising and operates as a subsidiary of Simplicity Marketing Ltd.

Hoopla

Series A in 2011
Hoopla is the new way to win for sales, marketing and customer service teams. Hoopla’s team performance software combines modern game mechanics, data analytics and broadcast-quality video in a powerfully simple application that makes it easy for front-line managers to motivate team performance and score more wins. Using Hoopla, managers can quickly create contests, competitions and leaderboards around any CRM metric, and broadcast live performance updates to TV, web and mobile screens throughout the company. Hoopla's Sales Motivation solutions engage the entire company in an exciting, play-to-win culture that delivers measurable gains in team productivity and performance. Founded in 2010, Hoopla is headquartered in Silicon Valley.

DriveFactor

Series A in 2011
DriveFactor is a technology company based in Glen Allen, Virginia, established in 2010, specializing in insurance telematics solutions. The company offers a software platform that analyzes driving data and generates a DriveFactor Score, which helps insurance companies underwrite driving insurance more effectively. DriveFactor's platform is designed with a dynamic and scalable architecture, capable of accepting data from various input methods and facilitating easy sharing with business partners. The company's expertise enables clients to customize telematics solutions tailored to their specific needs, both immediate and long-term.

Prognos Health

Series A in 2011
Prognos Health is a health tech company focused on healthcare analytics, offering a platform called prognosFACTOR. This innovative platform can quickly query billions of lab and health records from over 325 million de-identified patients, providing answers to clinically relevant healthcare questions in a fraction of the time traditionally required. Prognos Health allows clients to access HIPAA-compliant, patient-centric healthcare data through the Prognos Marketplace, facilitating a range of applications such as cohort design, patient journey studies, and health outcomes analysis. The company's clientele includes 25 of the top 30 pharmaceutical manufacturers and three of the top five health payers, highlighting its significant role in empowering precise decision-making throughout the healthcare landscape.

Putney

Series C in 2011
Putney, Inc. is a pharmaceutical company based in Portland, Maine, specializing in the development and sale of generic prescription medicines for pets. Founded in 2006, the company focuses on creating high-quality, cost-effective drugs that address common health issues in companion animals. Its product line includes veterinary-approved medications such as Enrofloxacin flavored tablets for bacterial infections in dogs and cats, Cefpodoxime Proxetil tablets for treating skin infections in dogs, and Carprofen caplets for pain management in dogs with osteoarthritis. Additionally, Putney offers human-approved pharmaceuticals, including Ampicillin sodium and Amoxicillin. The company markets and distributes its products through a network of veterinary distributors across the United States. As of 2016, Putney operates as a subsidiary of Dechra Pharmaceuticals plc.

NovaSom

Series D in 2011
NovaSom, Inc. is a diagnostic service provider specializing in home testing and evaluation for sleep-disordered breathing, particularly obstructive sleep apnea (OSA). Based in Glen Burnie, Maryland, and incorporated in 1992, the company is a Medicare-approved Independent Diagnostic Testing Facility and holds accreditation as an Ambulatory Care Sleep Diagnostic Center and Telehealth provider from The Joint Commission. NovaSom's FDA-cleared home testing system offers a convenient and accurate alternative to traditional in-laboratory sleep studies, allowing for effective diagnosis and continuous patient support. The company has also developed a cloud-based, collaborative patient management platform that facilitates integration with physicians and payers, enhancing the overall patient care experience.

PixelOptics

Series D in 2011
PixelOptics was founded in 2005 as the world's first composite lens company. Their unique and proprietary approach to lens design combines sound lens design principles and well-known, proven lens materials to create entirely new categories of eyeglass lenses.

ThingWorx

Series B in 2011
ThingWorx is a developer of a software application platform that facilitates the connection of people, systems, and devices in the modern digital landscape. The company specializes in creating and deploying secure connected applications across various environments, including cloud, intranet, and embedded platforms. By leveraging its technology, ThingWorx aims to drive significant operational innovation and enhance resource efficiency for businesses. Its solutions are designed to enable organizations to implement transformative changes that contribute to a more efficient and sustainable world.

Good Start Genetics

Series A in 2010
Good Start Genetics, Inc. is a molecular diagnostics company based in Cambridge, Massachusetts, focused on genetic screening for inherited diseases. Founded in 2007, the company aims to transform reproductive medicine by providing physicians and patients with actionable insights into inherited genetic disorders. Good Start Genetics offers a range of services, including EmbryVu, a preimplantation genetic screening test designed to enhance in vitro fertilization outcomes by identifying suitable embryos for implantation. The company employs advanced next-generation DNA sequencing technology, along with other established genetic screening methods, to deliver high carrier detection rates. Additionally, through its GoodStart Select program, it provides a comprehensive menu of genetic carrier screening tests for both known and novel mutations, all supported by a commitment to customer care and genetic counseling. As of August 2017, Good Start Genetics operates as a subsidiary of Invitae Corporation.

Swaptree

Series D in 2010
Swaptree is a website that allows users to trade books, CDs, DVDs and video games with other users for freeSwaptree.com provides a platform for trading among its customers. The Company offers a site where the user can freely swap new and used DVDs, CDs, video games, and books with other members. Swaptree.com conducts services in the United States.

Molecular Biometrics

Series B in 2010
Molecular Biometrics, Inc. is a metabolomics company based in Norwood, Massachusetts, focused on developing non-invasive methodologies for assessing biological functions in health and disease, as well as for drug discovery and development. Established in 2005, the company leverages innovative metabolomic technologies to create molecular gastronomy kits. Its applications span various fields, including reproductive health, neurodegenerative diseases such as Alzheimer's and Parkinson's, maternal-fetal medicine, pulmonary metabolism and edema, and lactate metabolism. By applying its proprietary technology, Molecular Biometrics aims to enhance the understanding and treatment of complex health issues.

Quinnova Pharmaceuticals

Series B in 2009
Quinnova Pharmaceuticals, Inc., a specialty pharmaceutical company, engages in the development and commercial sale of prescription drug products based on dermal drug delivery platforms. It offers HYDRO 40 foam, a dry skin treatment product; tersi foam, a leave-on foam indicated for the treatment of seborrheic dermatitis and tinea versicolor; rinnovi nail system, a prescription nail system that is designed to clean, treat, and protect diseased, damaged, brittle, and ingrown nails; and cleanse and treat, a pad delivery technology system for the treatment of acne. Quinnova Pharmaceuticals, Inc. was founded in 2003 and is based in Newtown, Pennsylvania.

MediaMath

Venture Round in 2009
MediaMath, Inc. is a digital advertising technology company that specializes in providing solutions for advertisers globally. Founded in 2007 and headquartered in New York, the company offers its TerminalOne platform, which facilitates data activation, automated execution, and optimization of advertising interactions across various media channels. MediaMath's programmatic marketing platform enhances customer engagement by utilizing predictive audience targeting and machine learning to ensure relevant messaging. In addition to its technology offerings, the company provides professional services that include programmatic strategy, analytics, technology support, and advertising operations, as well as training and certification programs in digital marketing. MediaMath operates additional offices in several cities across the United States and internationally, including London, Madrid, Berlin, Singapore, Tokyo, Sao Paulo, Sydney, Melbourne, and Bengaluru.

Avid Radiopharmaceuticals

Series D in 2009
Avid Radiopharmaceuticals is a biopharmaceutical company based in Philadelphia, PA, focused on developing molecular imaging agents designed to improve the medical management of chronic diseases. The company aims to create innovative imaging compounds that can detect and monitor the early stages of pathological changes, facilitating earlier diagnoses and enhancing the management of treatment options. One of their key products, Amyvid, serves as an imaging tool for positron emission tomography, specifically targeting the detection of beta-amyloid plaques in the brain, which is crucial for understanding conditions like Alzheimer's disease. Avid's mission underscores their commitment to transforming disease management through advanced imaging technologies.

Updater Home Services (formerly Bridgevine)

Venture Round in 2009
Updater’s Home Services Division provides innovative technology that simplifies the purchase of home subscription products across telecommunications, cable, satellite, home security, home improvement, and home energy.

Garnet Biotherapeutics

Series A in 2009
Garnet BioTherapeutics is a clinical stage, venture-backed cell therapy company focused on dermal-based regenerative therapy.

Tengion

Series C in 2008
Tengion is a clinical-stage biotechnology company focused on regenerative medicine, specializing in the development of neo-organs and neo-tissues derived from a patient's own cells. The company has successfully completed two Phase 2 clinical trials in the United States for its Tengion Neo-Bladder Augment, aimed at treating children with neurogenic bladder due to spina bifida and adults with neurogenic bladder resulting from spinal cord injury. Tengion's innovative approach seeks to eliminate the need for donor organs or anti-rejection medications by creating living cellular products that can regenerate or replace damaged tissues and organs. Additionally, the company has an investigational new drug application for its Neo-Urinary Conduit and plans to initiate a Phase 1 clinical trial for bladder cancer patients requiring bladder removal. Through its proprietary technology, Tengion aims to enhance patient outcomes by offering alternative solutions for organ and tissue repair.

Molecular Biometrics

Series A in 2008
Molecular Biometrics, Inc. is a metabolomics company based in Norwood, Massachusetts, focused on developing non-invasive methodologies for assessing biological functions in health and disease, as well as for drug discovery and development. Established in 2005, the company leverages innovative metabolomic technologies to create molecular gastronomy kits. Its applications span various fields, including reproductive health, neurodegenerative diseases such as Alzheimer's and Parkinson's, maternal-fetal medicine, pulmonary metabolism and edema, and lactate metabolism. By applying its proprietary technology, Molecular Biometrics aims to enhance the understanding and treatment of complex health issues.

Swaptree

Series C in 2008
Swaptree is a website that allows users to trade books, CDs, DVDs and video games with other users for freeSwaptree.com provides a platform for trading among its customers. The Company offers a site where the user can freely swap new and used DVDs, CDs, video games, and books with other members. Swaptree.com conducts services in the United States.

NuPathe

Series B in 2008
NuPathe Inc. is a specialty pharmaceutical company dedicated to developing and commercializing innovative therapies for neurological and psychiatric disorders. The company's flagship product is Zecuity, a transdermal system utilizing sumatriptan for the acute treatment of migraines in adults. In addition to Zecuity, NuPathe is advancing a pipeline of product candidates, including NP201, designed for the continuous treatment of Parkinson's disease, and NP202, aimed at the long-term management of schizophrenia and bipolar disorder. Both candidates leverage the company's proprietary Long-Acting Delivery technology, which facilitates extended medication release through biodegradable implants. Founded in 2005 and based in Malvern, Pennsylvania, NuPathe operates as a subsidiary of Teva Pharmaceutical Industries Limited. The company actively seeks partnerships to enhance the commercial potential of its products in the United States and internationally.

Portico Systems

Venture Round in 2008
Portico Systems specializes in software applications for healthcare organizations, focusing on the management of provider networks. The company's technology facilitates the design, construction, servicing, and value-based reimbursement of complex provider networks. By automating essential network management tasks such as provider enrollment, credentialing, contracting, and pricing, Portico enhances the efficiency of health plans while reducing medical, administrative, and information technology costs. This transformation improves performance management within provider networks, ultimately supporting healthcare organizations in delivering better value to their stakeholders.

Alverix

Series A in 2008
Alverix specializes in point-of-care diagnostics technology, focusing on the design and manufacture of low-cost, handheld reader devices that deliver laboratory-level accuracy and precision. The company collaborates with diagnostic and OEM manufacturers to enhance test accuracy, improve portability, and develop new assays suitable for various settings, including physician offices, laboratory outreach, retail clinics, and home use. Alverix emphasizes strong product design, development, and high-volume manufacturing capabilities, positioning itself at the forefront of shifting diagnostic testing from traditional laboratories to locations where rapid results are essential for effective patient care.

Updater Home Services (formerly Bridgevine)

Series B in 2007
Updater’s Home Services Division provides innovative technology that simplifies the purchase of home subscription products across telecommunications, cable, satellite, home security, home improvement, and home energy.

Cellumen

Series B in 2007
Cellumen specializes in cellular systems biology solutions that enhance drug discovery and safety assessment processes for biopharmaceutical researchers. By providing advanced tools for early safety evaluation and discovery toxicology, Cellumen helps organizations improve the accuracy of predicting drug efficacy and safety, ultimately reducing failure rates and development costs. The company's innovative approach addresses the complexities of disease and safety, making it a valuable partner for leading institutions such as the Mayo Clinic, Hamamatsu Photonics K.K., the EPA, FDA, NIH, and prominent pharmaceutical companies. Through its commitment to advancing drug development, Cellumen plays a crucial role in the biopharmaceutical industry.

Avid Radiopharmaceuticals

Series C in 2007
Avid Radiopharmaceuticals is a biopharmaceutical company based in Philadelphia, PA, focused on developing molecular imaging agents designed to improve the medical management of chronic diseases. The company aims to create innovative imaging compounds that can detect and monitor the early stages of pathological changes, facilitating earlier diagnoses and enhancing the management of treatment options. One of their key products, Amyvid, serves as an imaging tool for positron emission tomography, specifically targeting the detection of beta-amyloid plaques in the brain, which is crucial for understanding conditions like Alzheimer's disease. Avid's mission underscores their commitment to transforming disease management through advanced imaging technologies.

Authentium

Series B in 2007
Authentium, Inc. provides security software and services. It offers SafeCentral, a secure Internet that is designed to enable protected e-commerce; and Command Antivirus, an antivirus product. The company's technologies are used by software providers. Authentium, Inc. was founded in 1999 and is based in Palm Beach Gardens, Florida.

Beyond.com

Series A in 2007
Beyond.com, Inc. operates an online career network to connect job seekers and employers through career channels, and industry and regional communities. Beyond.com, it’s all about focus – and results. You identify the candidates you want to reach, and we’ll help you target them through relevant industry, local and specialty channels. Using our precise targeting abilities, we are able to deliver quality results through recruitment advertising, email marketing, mobile and social channels, and other highly effective tactics. A focused search means more qualified candidates. Get started today, with Beyond.com.

Advanced BioHealing

Series C in 2007
Advanced BioHealing is an industry leader in the science of regenerative medicine. The Company is focused on the commercialization of cell-based and tissue-engineered products. It currently markets the FDA-approved product Dermagraft®, for diabetic foot ulcers. Additionally, the Company's development pipeline includes a next-generation bioengineered tissue product which is in clinical trials. ABH is a privately held company with research & development offices in New York, NY and manufacturing operations in La Jolla, CA.

AdvantEdge Healthcare Solutions

Series A in 2006
AdvantEdge Healthcare Solutions, Inc. is a company that specializes in providing software and services for the healthcare industry, focusing on revenue cycle management and practice management. Founded in 1999 and based in Warren, New Jersey, AdvantEdge offers a range of medical billing solutions tailored to various specialties, including radiology, cardiology, anesthesia, pain management, neonatology, and internal medicine. The company serves hospitals and office-based specialty physician practices, delivering services such as billing, coding, compliance consulting, reporting, and business analytics. By enabling healthcare providers to enhance decision-making, optimize financial performance, and streamline operations, AdvantEdge aims to support its clients in navigating the complexities of healthcare management while minimizing compliance risks.

Portico Systems

Series A in 2006
Portico Systems specializes in software applications for healthcare organizations, focusing on the management of provider networks. The company's technology facilitates the design, construction, servicing, and value-based reimbursement of complex provider networks. By automating essential network management tasks such as provider enrollment, credentialing, contracting, and pricing, Portico enhances the efficiency of health plans while reducing medical, administrative, and information technology costs. This transformation improves performance management within provider networks, ultimately supporting healthcare organizations in delivering better value to their stakeholders.

NuPathe

Series A in 2006
NuPathe Inc. is a specialty pharmaceutical company dedicated to developing and commercializing innovative therapies for neurological and psychiatric disorders. The company's flagship product is Zecuity, a transdermal system utilizing sumatriptan for the acute treatment of migraines in adults. In addition to Zecuity, NuPathe is advancing a pipeline of product candidates, including NP201, designed for the continuous treatment of Parkinson's disease, and NP202, aimed at the long-term management of schizophrenia and bipolar disorder. Both candidates leverage the company's proprietary Long-Acting Delivery technology, which facilitates extended medication release through biodegradable implants. Founded in 2005 and based in Malvern, Pennsylvania, NuPathe operates as a subsidiary of Teva Pharmaceutical Industries Limited. The company actively seeks partnerships to enhance the commercial potential of its products in the United States and internationally.

Rubicor Medical

Series C in 2006
Rubicor Medical is develops and distributes technologically advanced, disposable, non-invasive, breast biopsy devices.

Authentium

Series A in 2006
Authentium, Inc. provides security software and services. It offers SafeCentral, a secure Internet that is designed to enable protected e-commerce; and Command Antivirus, an antivirus product. The company's technologies are used by software providers. Authentium, Inc. was founded in 1999 and is based in Palm Beach Gardens, Florida.

NexTone Communications

Series D in 2005
NexTone Communications, based in Rockville, Maryland, specializes in providing software solutions for internet-based voice and data convergence aimed at service providers. The company develops technology that enables communications firms to efficiently route, manage, and control internet telephone calls. By focusing on the evolving needs of the communications industry, NexTone creates products that facilitate the delivery of next-generation applications, positioning itself as a key player in the advancement of internet telephone services.
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