Safeguard Scientifics

Safeguard Scientifics, Inc., established in 1953, is a growth capital firm headquartered in Radnor, Pennsylvania, with an additional office in Weston, Massachusetts. The company specializes in providing growth capital and operational support to technology companies operating within the healthcare, financial services, and digital media sectors. Safeguard typically invests between $5 million and $25 million in growth equity financing and between $5 million and $10 million in early-stage financing. It prefers to be the largest shareholder in its portfolio companies, usually taking a 20% to 50% stake, and often seeks a Board seat. The firm focuses on companies with proprietary technology and intellectual property, and it has a history of fostering innovation and building market leaders.

Mark A. Herndon

Senior Vice President and CFO

David Luk

Principal

Mark Mitchell

Managing Director

Erik Rasmussen

Senior Vice President and Managing Director

Eric C. Salzman

CEO

Wei Zhang Ph.D

Principal and Healthcare Venture Capitalist

Past deals in Pennsylvania

Syapse

Venture Round in 2022
Syapse, Inc. is a company that develops a precision medicine software platform aimed at improving cancer care through the integration and analysis of diverse clinical, molecular, treatment, and outcomes data. By leveraging real-world evidence, Syapse enables healthcare organizations to collaborate effectively, providing comprehensive patient insights that inform clinical decisions. Its primary offering, the Syapse Learning Health Network, serves as a global data-sharing network that supports oncologists and life sciences collaborators with actionable insights derived from real-world data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse works to enhance precision medicine programs and drive impactful outcomes for cancer patients. The company has also established a strategic partnership with Pfizer to further its mission in the field of precision oncology.

Syapse

Series F in 2020
Syapse, Inc. is a company that develops a precision medicine software platform aimed at improving cancer care through the integration and analysis of diverse clinical, molecular, treatment, and outcomes data. By leveraging real-world evidence, Syapse enables healthcare organizations to collaborate effectively, providing comprehensive patient insights that inform clinical decisions. Its primary offering, the Syapse Learning Health Network, serves as a global data-sharing network that supports oncologists and life sciences collaborators with actionable insights derived from real-world data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse works to enhance precision medicine programs and drive impactful outcomes for cancer patients. The company has also established a strategic partnership with Pfizer to further its mission in the field of precision oncology.

Trice Medical

Series C in 2019
Trice Medical, Inc. is a company that specializes in the development of innovative orthopedic diagnostic devices featuring integrated camera-enabled and needle-based technologies. Founded in 2011 and headquartered in Malvern, Pennsylvania, Trice Medical aims to enhance patient care by providing immediate and accurate diagnostic solutions that can be administered in a physician's office. Their products facilitate minimally invasive procedures that are designed to be painless, cosmetically undetectable, and of surgical grade quality. By optimizing the diagnostic process, Trice Medical seeks to eliminate inaccuracies associated with traditional indirect modalities, thereby reducing costs for the healthcare system while improving the overall patient experience.

Syapse

Series D in 2017
Syapse, Inc. is a company that develops a precision medicine software platform aimed at improving cancer care through the integration and analysis of diverse clinical, molecular, treatment, and outcomes data. By leveraging real-world evidence, Syapse enables healthcare organizations to collaborate effectively, providing comprehensive patient insights that inform clinical decisions. Its primary offering, the Syapse Learning Health Network, serves as a global data-sharing network that supports oncologists and life sciences collaborators with actionable insights derived from real-world data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse works to enhance precision medicine programs and drive impactful outcomes for cancer patients. The company has also established a strategic partnership with Pfizer to further its mission in the field of precision oncology.

Trice Medical

Series C in 2017
Trice Medical, Inc. is a company that specializes in the development of innovative orthopedic diagnostic devices featuring integrated camera-enabled and needle-based technologies. Founded in 2011 and headquartered in Malvern, Pennsylvania, Trice Medical aims to enhance patient care by providing immediate and accurate diagnostic solutions that can be administered in a physician's office. Their products facilitate minimally invasive procedures that are designed to be painless, cosmetically undetectable, and of surgical grade quality. By optimizing the diagnostic process, Trice Medical seeks to eliminate inaccuracies associated with traditional indirect modalities, thereby reducing costs for the healthcare system while improving the overall patient experience.

Noble.MD

Seed Round in 2016
Noble.MD is a healthcare technology company based in Bryn Mawr, Pennsylvania, founded in 2012. The company develops Theo, a digital healthcare advisory platform designed to assist patients in identifying health and behavioral risks. The platform actively engages patients by providing programs and interventions to help them manage these risks. By capturing essential patient data at the time of care, Noble.MD facilitates value-based reimbursement and aligns the interests of providers and payers, enhancing the processes of risk identification, coding, and management.

Syapse

Series C in 2016
Syapse, Inc. is a company that develops a precision medicine software platform aimed at improving cancer care through the integration and analysis of diverse clinical, molecular, treatment, and outcomes data. By leveraging real-world evidence, Syapse enables healthcare organizations to collaborate effectively, providing comprehensive patient insights that inform clinical decisions. Its primary offering, the Syapse Learning Health Network, serves as a global data-sharing network that supports oncologists and life sciences collaborators with actionable insights derived from real-world data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse works to enhance precision medicine programs and drive impactful outcomes for cancer patients. The company has also established a strategic partnership with Pfizer to further its mission in the field of precision oncology.

Clutch

Series B in 2015
Clutch serves as a customer marketing platform for business-to-consumer brands. It provides traditional marketing CRM, loyalty, gift card, mobile, email, and direct mail solutions. The company was created to help businesses succeed in an evolving marketing landscape. Since 2012, they have continued to grow their platform into an innovative, data-centric marketing solution with one focus that empowering brands with the best technology so that they can identify, understand and motivate their customers.

Trice Medical

Series B in 2015
Trice Medical, Inc. is a company that specializes in the development of innovative orthopedic diagnostic devices featuring integrated camera-enabled and needle-based technologies. Founded in 2011 and headquartered in Malvern, Pennsylvania, Trice Medical aims to enhance patient care by providing immediate and accurate diagnostic solutions that can be administered in a physician's office. Their products facilitate minimally invasive procedures that are designed to be painless, cosmetically undetectable, and of surgical grade quality. By optimizing the diagnostic process, Trice Medical seeks to eliminate inaccuracies associated with traditional indirect modalities, thereby reducing costs for the healthcare system while improving the overall patient experience.

Trice Medical

Series B in 2014
Trice Medical, Inc. is a company that specializes in the development of innovative orthopedic diagnostic devices featuring integrated camera-enabled and needle-based technologies. Founded in 2011 and headquartered in Malvern, Pennsylvania, Trice Medical aims to enhance patient care by providing immediate and accurate diagnostic solutions that can be administered in a physician's office. Their products facilitate minimally invasive procedures that are designed to be painless, cosmetically undetectable, and of surgical grade quality. By optimizing the diagnostic process, Trice Medical seeks to eliminate inaccuracies associated with traditional indirect modalities, thereby reducing costs for the healthcare system while improving the overall patient experience.

Syapse

Series B in 2014
Syapse, Inc. is a company that develops a precision medicine software platform aimed at improving cancer care through the integration and analysis of diverse clinical, molecular, treatment, and outcomes data. By leveraging real-world evidence, Syapse enables healthcare organizations to collaborate effectively, providing comprehensive patient insights that inform clinical decisions. Its primary offering, the Syapse Learning Health Network, serves as a global data-sharing network that supports oncologists and life sciences collaborators with actionable insights derived from real-world data. Founded in 2008 and headquartered in San Francisco, California, with an additional office in Radnor, Pennsylvania, Syapse works to enhance precision medicine programs and drive impactful outcomes for cancer patients. The company has also established a strategic partnership with Pfizer to further its mission in the field of precision oncology.

Clutch

Venture Round in 2013
Clutch serves as a customer marketing platform for business-to-consumer brands. It provides traditional marketing CRM, loyalty, gift card, mobile, email, and direct mail solutions. The company was created to help businesses succeed in an evolving marketing landscape. Since 2012, they have continued to grow their platform into an innovative, data-centric marketing solution with one focus that empowering brands with the best technology so that they can identify, understand and motivate their customers.

Quinnova Pharmaceuticals

Series B in 2009
Quinnova Pharmaceuticals, Inc., a specialty pharmaceutical company, engages in the development and commercial sale of prescription drug products based on dermal drug delivery platforms. It offers HYDRO 40 foam, a dry skin treatment product; tersi foam, a leave-on foam indicated for the treatment of seborrheic dermatitis and tinea versicolor; rinnovi nail system, a prescription nail system that is designed to clean, treat, and protect diseased, damaged, brittle, and ingrown nails; and cleanse and treat, a pad delivery technology system for the treatment of acne. Quinnova Pharmaceuticals, Inc. was founded in 2003 and is based in Newtown, Pennsylvania.

Avid Radiopharmaceuticals

Series D in 2009
Avid Radiopharmaceuticals is a biopharmaceutical company based in Philadelphia, PA, focused on developing molecular imaging agents designed to improve the medical management of chronic diseases. The company aims to create innovative imaging compounds that can detect and monitor the early stages of pathological changes, facilitating earlier diagnoses and enhancing the management of treatment options. One of their key products, Amyvid, serves as an imaging tool for positron emission tomography, specifically targeting the detection of beta-amyloid plaques in the brain, which is crucial for understanding conditions like Alzheimer's disease. Avid's mission underscores their commitment to transforming disease management through advanced imaging technologies.

Avid Radiopharmaceuticals

Series C in 2007
Avid Radiopharmaceuticals is a biopharmaceutical company based in Philadelphia, PA, focused on developing molecular imaging agents designed to improve the medical management of chronic diseases. The company aims to create innovative imaging compounds that can detect and monitor the early stages of pathological changes, facilitating earlier diagnoses and enhancing the management of treatment options. One of their key products, Amyvid, serves as an imaging tool for positron emission tomography, specifically targeting the detection of beta-amyloid plaques in the brain, which is crucial for understanding conditions like Alzheimer's disease. Avid's mission underscores their commitment to transforming disease management through advanced imaging technologies.
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