180 Degree Capital

180 Degree Capital is an investment firm located in Montclair, New Jersey, specializing in a range of sectors including technology, nanotechnology, energy, clean technology, healthcare, and electronics. Established in 1981, the firm is recognized as a proactive investor in small technology companies, focusing on those that develop innovative nanoscale-enabled solutions across various applications such as solid state lighting, memory devices, and life sciences. 180 Degree Capital often collaborates with other venture capital firms and strategic investors, positioning itself as a lead investor in many cases. The firm adheres to a traditional early-stage venture capital model, seeking to support technology-based startups through its extensive network, technical expertise, and financial resources. It prioritizes investments in companies that demonstrate strong scientific, technological, and business capabilities, particularly those with proprietary technologies and market-centric strategies aimed at dominating significant product categories. Though primarily focused on the United States, the firm has occasionally explored international investments.

Charles E. Harris

Chairman and CEO

Blake Stevens

Associate

98 past transactions

EchoPixel

Series A in 2017
EchoPixel, Inc. is a company that specializes in 3D medical visualization software, providing tools for medical professionals to interact with patient-specific organs and tissues in an immersive environment. Its flagship product, the True 3D Viewer, is a real-time interactive virtual reality system that enhances the ability of doctors to identify, evaluate, and dissect anatomical structures. Additionally, the True 3D Medical Education Viewer aids medical students in understanding structural 3D biology by utilizing computer tomography and magnetic resonance images. EchoPixel also offers a holographic intraoperative software that supports structural heart procedures through interactive 3D anatomical imaging. Founded in 2012 and based in Mountain View, California, the company aims to improve diagnostic and educational capabilities in the medical field through advanced imaging technology.

NGX Bio

Venture Round in 2017
NGX Bio is an online marketplace that facilitates access to DNA sequencing services, connecting researchers with high-quality genomic resources. By streamlining the sequencing process, the platform allows customers to complete their projects in a single transaction, ensuring cost-effectiveness through partnerships with providers that have available capacity. NGX Bio offers a comprehensive range of services, including design and planning, sample preparation, sequencing, and data analysis. Additionally, the company features an online project management tool that enhances sample tracking through the use of barcoded tubes and plates. Serving a global clientele, NGX Bio simplifies the sequencing experience for researchers worldwide.

ORIG3N

Venture Round in 2017
ORIG3N, Inc. is a biotechnology company focused on developing innovative treatments for rare genetically inherited diseases, particularly targeting conditions related to the heart, liver, and neurodegeneration. Founded in 2014 and based in Boston, Massachusetts, ORIG3N utilizes induced pluripotent stem cell technology that allows for the differentiation of cells into any type found in the body. This technology is employed to test drug efficacy, screen for medication toxicity, and create personalized treatment pathways. The company offers a range of products, including LifeProfiles, which provides genetic insights related to fitness, metabolism, and exercise recovery; the Run DNA test for optimizing running performance; AURA, which assesses skin health; and Life Capsule, a repository for blood cells aimed at regenerative medicine development.

Lodo Therapeutics

Series A in 2016
Lodo Therapeutics Corporation is a drug discovery and development company dedicated to creating novel therapeutics derived from natural sources. It focuses on addressing significant health challenges, particularly resistant infectious diseases and cancers, by collaborating with global pharmaceutical companies and leading non-governmental organizations. Founded to realize the scientific vision of Dr. Sean Brady from Rockefeller University, Lodo Therapeutics utilizes a genome-based, culture-independent platform to discover and characterize small molecules sourced from environmental microbial DNA. This innovative approach leverages advancements in DNA sequencing and bioinformatics to explore the untapped potential of microbial evolution, aiming to identify therapeutically valuable pharmaceutical products. Headquartered in New York City at the Alexandria Center for Life Science, Lodo Therapeutics is committed to harnessing the power of nature in the fight against undruggable targets and high unmet medical needs.

TARA Biosystems

Seed Round in 2016
TARA Biosystems, Inc. is a biotechnology company focused on developing organ-on-a-chip technology, specifically human cardiac tissue models, to enhance drug discovery and safety assessments. Founded in 2014 and based in the United States, the company utilizes stem cell-derived cardiac tissue that mimics adult physiological conditions, enabling precise measurement of cardiac functionality. This innovative platform aims to facilitate the faster and safer development of new therapies by providing predictive in vitro models that can assess the effects of drug compounds on heart function without the need for human testing. Through its advanced technology, TARA Biosystems seeks to improve the health of patients by enabling more reliable assessments of cardiac drug efficacy and safety.

Petra Pharma

Series A in 2016
Petra Pharma Corporation is a clinical-stage pharmaceutical company based in New York that focuses on discovering and developing therapies targeting phosphoinositide (PI) signaling pathways. Established in 2015, the company aims to create novel small molecules that address serious medical conditions, particularly cancer and metabolic diseases. By honing in on unique enzyme targets involved in critical cellular processes such as cell division, growth, trafficking, and signaling, Petra Pharma seeks to develop innovative treatments that can enhance human health and provide new options for healthcare providers.

ORIG3N

Series A in 2015
ORIG3N, Inc. is a biotechnology company focused on developing innovative treatments for rare genetically inherited diseases, particularly targeting conditions related to the heart, liver, and neurodegeneration. Founded in 2014 and based in Boston, Massachusetts, ORIG3N utilizes induced pluripotent stem cell technology that allows for the differentiation of cells into any type found in the body. This technology is employed to test drug efficacy, screen for medication toxicity, and create personalized treatment pathways. The company offers a range of products, including LifeProfiles, which provides genetic insights related to fitness, metabolism, and exercise recovery; the Run DNA test for optimizing running performance; AURA, which assesses skin health; and Life Capsule, a repository for blood cells aimed at regenerative medicine development.

AgBiome

Series B in 2015
AgBiome, LLC is a biotechnology company based in Durham, North Carolina, that focuses on developing biological products to address significant challenges in agriculture, particularly soil-borne diseases affecting greenhouse and major row crops. Utilizing advanced genomics and screening technologies, AgBiome identifies plant-associated microbes that can enhance plant health, improve pest resistance, and increase crop yields. The company operates a state-of-the-art laboratory and greenhouse facility and collaborates with prominent agricultural firms to expedite its research and product development. AgBiome's offerings include fungicides that protect crops from various diseases and a platform for capturing and screening diverse microbes for agricultural applications. Established in 2012, AgBiome aims to provide sustainable solutions that support global food production and address critical agricultural issues such as insect and nematode control.

ORIG3N

Venture Round in 2015
ORIG3N, Inc. is a biotechnology company focused on developing innovative treatments for rare genetically inherited diseases, particularly targeting conditions related to the heart, liver, and neurodegeneration. Founded in 2014 and based in Boston, Massachusetts, ORIG3N utilizes induced pluripotent stem cell technology that allows for the differentiation of cells into any type found in the body. This technology is employed to test drug efficacy, screen for medication toxicity, and create personalized treatment pathways. The company offers a range of products, including LifeProfiles, which provides genetic insights related to fitness, metabolism, and exercise recovery; the Run DNA test for optimizing running performance; AURA, which assesses skin health; and Life Capsule, a repository for blood cells aimed at regenerative medicine development.

AgBiome

Venture Round in 2014
AgBiome, LLC is a biotechnology company based in Durham, North Carolina, that focuses on developing biological products to address significant challenges in agriculture, particularly soil-borne diseases affecting greenhouse and major row crops. Utilizing advanced genomics and screening technologies, AgBiome identifies plant-associated microbes that can enhance plant health, improve pest resistance, and increase crop yields. The company operates a state-of-the-art laboratory and greenhouse facility and collaborates with prominent agricultural firms to expedite its research and product development. AgBiome's offerings include fungicides that protect crops from various diseases and a platform for capturing and screening diverse microbes for agricultural applications. Established in 2012, AgBiome aims to provide sustainable solutions that support global food production and address critical agricultural issues such as insect and nematode control.

Enumeral Biomedical Holdings

Post in 2014
Enumeral Biomedical focuses on advancing immunology by developing novel antibody immunotherapies that enhance the immune system's ability to target diseased cells. Utilizing a microengraving process enabled by nanotechnology, the company extensively explores the human immune microenvironment. This approach allows for the identification and characterization of new drugs that address cancer, infectious, and inflammatory diseases. Enumeral Biomedical aims to provide solutions for patients who are often underserved in the diagnosis and treatment of autoimmune and inflammatory conditions, thereby contributing to the field of personalized medicine and therapeutic discovery.

NGX Bio

Seed Round in 2014
NGX Bio is an online marketplace that facilitates access to DNA sequencing services, connecting researchers with high-quality genomic resources. By streamlining the sequencing process, the platform allows customers to complete their projects in a single transaction, ensuring cost-effectiveness through partnerships with providers that have available capacity. NGX Bio offers a comprehensive range of services, including design and planning, sample preparation, sequencing, and data analysis. Additionally, the company features an online project management tool that enhances sample tracking through the use of barcoded tubes and plates. Serving a global clientele, NGX Bio simplifies the sequencing experience for researchers worldwide.

HZO

Series B in 2014
HZO specializes in protective nano and conformal coatings designed to safeguard electronic components in challenging environments. Founded in 2011 and headquartered in Morrisville, North Carolina, the company offers innovative water protection solutions tailored for electronics manufacturers. By utilizing advanced thin-film protective technology, including Parylene coatings, HZO enables manufacturers to create durable products capable of withstanding corrosive and liquid exposure. Its focus on nanotechnology and waterproofing allows for effective protection of electronic circuits and components, ensuring reliability in wet and harsh conditions.

Promuc

Venture Round in 2014
ProMuc, Inc. develops synthetic mucins for lubrication and antimicrobial applications.

Metabolon

Series E in 2014
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

ABSMaterials

Series B in 2013
ABS Materials designs, develops, and delivers solutions for ground, surface, and municipal water contamination. Its solutions include VoC-Eater system, which destroys pharmaceuticals, chlorinated solvents, herbicides, endocrine disruptors, PCBs, dyes, and phenols to outflow clean water; Osorb, a solution to destroy persistent organic pollutants in the groundwater; and Iron-Osorb, an inert sand-like glass used on TCE/PCE/DCE/PCBs. The company’s solutions are used to clean solvents, pesticides, and other persistent organic pollutants from the water, soil, and air. It offers its systems on a rental and long term lease basis. The company was founded in 2008 and is based in Wooster, Ohio with an additional office in Houston, Texas.

EchoPixel

Seed Round in 2013
EchoPixel, Inc. is a company that specializes in 3D medical visualization software, providing tools for medical professionals to interact with patient-specific organs and tissues in an immersive environment. Its flagship product, the True 3D Viewer, is a real-time interactive virtual reality system that enhances the ability of doctors to identify, evaluate, and dissect anatomical structures. Additionally, the True 3D Medical Education Viewer aids medical students in understanding structural 3D biology by utilizing computer tomography and magnetic resonance images. EchoPixel also offers a holographic intraoperative software that supports structural heart procedures through interactive 3D anatomical imaging. Founded in 2012 and based in Mountain View, California, the company aims to improve diagnostic and educational capabilities in the medical field through advanced imaging technology.

AgBiome

Series A in 2013
AgBiome, LLC is a biotechnology company based in Durham, North Carolina, that focuses on developing biological products to address significant challenges in agriculture, particularly soil-borne diseases affecting greenhouse and major row crops. Utilizing advanced genomics and screening technologies, AgBiome identifies plant-associated microbes that can enhance plant health, improve pest resistance, and increase crop yields. The company operates a state-of-the-art laboratory and greenhouse facility and collaborates with prominent agricultural firms to expedite its research and product development. AgBiome's offerings include fungicides that protect crops from various diseases and a platform for capturing and screening diverse microbes for agricultural applications. Established in 2012, AgBiome aims to provide sustainable solutions that support global food production and address critical agricultural issues such as insect and nematode control.

Nantero

Series D in 2012
Nantero, Inc. is a nanotechnology company based in Woburn, Massachusetts, that specializes in the development of semiconductor products utilizing carbon nanotubes. Founded in 2001, Nantero focuses on creating nonvolatile random access memory (NRAM) chips, which provide high-density, high-speed storage solutions for a variety of applications, including smartphones, tablets, computers, and industrial systems. The company's NRAM technology offers advantages over traditional memory types, such as zero power consumption in standby mode, making it suitable for both standalone and embedded memory applications. In addition to NRAM, Nantero produces nanoelectromechanical switches and other semiconductor products, and collaborates with licensees to expand the use of its nanotube-based technology across various sectors.

D-Wave Systems

Venture Round in 2012
D-Wave Systems Inc. specializes in the development and integration of superconducting quantum computers. As the first commercial supplier of quantum computers, the company offers products such as The D-Wave Two System, D-Wave Hybrid—a hybrid workflow platform for quantum-classical applications—and Leap, a cloud-based service that enables real-time access to quantum computing resources along with open-source development tools and educational materials. D-Wave's quantum computers are applied across various sectors, including defense, finance, energy, and academia, addressing challenges in mission planning, logistics, machine learning, optimization problems, and more. In addition to its quantum computing systems, the company provides professional services, training, and customer support to enhance user experience. Founded in 1999 and headquartered in Burnaby, Canada, D-Wave has expanded its presence with sales offices in the United States, Europe, and Asia.

Kovio

Venture Round in 2012
Kovio Inc. is a privately held company based in Silicon Valley that specializes in the development of printed silicon products. Utilizing innovative manufacturing techniques that merge graphics printing with silicon-based semiconductor technology, Kovio produces low-cost solutions for various applications. The company focuses on markets such as Near Field Communication (NFC) and Electronic Article Surveillance (EAS), designing and manufacturing products like Radio Frequency Identification (RFID) tags and NFC Barcodes. Founded in the MIT Media Laboratory, Kovio aims to create a new category of semiconductor products that leverage the advantages of printed electronics.

OpGen

Series C in 2012
OpGen, Inc. is a precision medicine company focused on developing molecular diagnostics and informatics to address infectious diseases. Headquartered in Gaithersburg, Maryland, OpGen offers a range of products designed to provide clinicians with rapid and actionable information regarding life-threatening infections, ultimately aiming to enhance patient outcomes and reduce the spread of multidrug-resistant organisms (MDROs). Its key offerings include the Acuitas AMR Gene Panel, which detects bacterial nucleic acids and genetic markers of antimicrobial resistance, and the QuickFISH and PNA FISH products for pathogen identification in blood cultures. Additionally, OpGen provides the Acuitas Lighthouse informatics system, a cloud-based platform that integrates clinical lab results with patient and hospital data to support the management of antimicrobial-resistant infections. The company collaborates with the New York State Department of Health to develop solutions for detecting and tracking such infections in healthcare settings. Established in 2001, OpGen continues to innovate in addressing the critical challenge of antibiotic resistance through its advanced molecular microbiology solutions.

Senova Systems

Series B in 2012
Senova Systems, Inc. is a company based in Sunnyvale, California, that specializes in the development, manufacturing, and sale of pH meters for various industries, including life sciences, food and beverage, dairy, water, and consumer products. Founded in 2007, the company has introduced an innovative calibration-free pHit™ pH sensor platform that utilizes non-glass electrodes, marking a significant advancement in pH measurement technology. This solid-state sensor replaces traditional glass electrodes and does not require user calibration, facilitating novel applications in healthcare and other specialized fields that were previously unattainable with conventional pH measurement methods. Senova Systems aims to provide reliable and advanced pH measurement solutions to enhance various scientific and industrial processes.

BridgeLux

Venture Round in 2011
Bridgelux, Inc. is a developer and manufacturer of solid-state lighting technologies based in Fremont, California. Established in 2002, the company specializes in high-power, energy-efficient light-emitting diode (LED) solutions, offering a diverse range of products including LED arrays, chips, subsystems, and surface mounts. Its product lineup encompasses various applications, such as downlights, streetlights, and replacement lamps, serving sectors like retail, healthcare, and industrial environments. Bridgelux aims to replace traditional lighting technologies with its sustainable and cost-effective solutions, contributing to global energy efficiency efforts. The company also provides testing, application engineering, and reference design services to support its clients. In addition to its headquarters, Bridgelux has strategic partnerships and additional locations globally, enhancing its market reach and technological innovation. The company was previously known as eLite Optoelectronics, Inc. before rebranding in April 2006.

Contour Energy

Series C in 2011
Contour Energy is a company of portable power that commercializes customizable battery technologies for a wide range of cross-industry applications. It designs its next-generation battery systems to deliver unprecedented improvements in energy and power density, and are capable of performing in extreme operating conditions at significantly improved costs. Founded through the collaboration of Caltech and CNRS, the French National Center for Scientific Research, It combines expertise in nano-materials science, patented fluorine-based battery chemistries and manufacturing processes to significantly advance the state of portable power. With its headquarters in Azusa in California, a team of battery industry leaders from Caltech, Energizer, General Electric, Hewlett-Packard, Sanyo and Valence Technologies manages it. Private entrepreneurs hold it.

Metabolon

Series D in 2011
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

HZO

Series B in 2011
HZO specializes in protective nano and conformal coatings designed to safeguard electronic components in challenging environments. Founded in 2011 and headquartered in Morrisville, North Carolina, the company offers innovative water protection solutions tailored for electronics manufacturers. By utilizing advanced thin-film protective technology, including Parylene coatings, HZO enables manufacturers to create durable products capable of withstanding corrosive and liquid exposure. Its focus on nanotechnology and waterproofing allows for effective protection of electronic circuits and components, ensuring reliability in wet and harsh conditions.

PWA

Series A in 2011
PWA specializes in advanced water treatment technologies, primarily focusing on its patented Osorb® media system. This innovative, regenerable media effectively removes free, dispersed, and soluble hydrocarbons, along with toxic contaminants from oilfield water and gas streams. The main application of Osorb® is in the treatment of produced water, ensuring compliance with discharge and reinjection standards. By addressing the critical need for safe and efficient water management in the oil and gas industry, PWA plays a significant role in enhancing environmental sustainability and resource recovery.

Kovio

Venture Round in 2011
Kovio Inc. is a privately held company based in Silicon Valley that specializes in the development of printed silicon products. Utilizing innovative manufacturing techniques that merge graphics printing with silicon-based semiconductor technology, Kovio produces low-cost solutions for various applications. The company focuses on markets such as Near Field Communication (NFC) and Electronic Article Surveillance (EAS), designing and manufacturing products like Radio Frequency Identification (RFID) tags and NFC Barcodes. Founded in the MIT Media Laboratory, Kovio aims to create a new category of semiconductor products that leverage the advantages of printed electronics.

Cobalt Technologies

Series D in 2011
Cobalt Technologies is a company focused on developing innovative technologies for biofuels, particularly in the production of bio-based chemicals. Founded in 2005 and headquartered in Mountain View, California, Cobalt is pioneering methods to produce low-cost, commercial-scale biobutanol, an alternative to traditional petroleum-based products. This next-generation bio n-butanol serves as an ingredient in various applications, including fuels, bio-based plastics, synthetic rubber, paints, adhesives, and solvents. By offering cost-effective substitutes to petroleum-derived chemicals, Cobalt aims to create fuels that burn cleaner and have a reduced environmental impact.

Nano Terra

Debt Financing in 2011
Nano Terra, Inc. is a surface engineering and nanotechnology co-development company based in Cambridge, Massachusetts. Established in 2005, it specializes in the development and commercialization of advanced materials, coatings, polymer formulations, and high-resolution printing technologies. The company focuses on creating innovative solutions, including ultra-thin electronic displays, fuel cells, sensors, and solar power devices. It serves a diverse range of industries, including aerospace, automotive, healthcare, and electronics, by leveraging its expertise in surface science and advanced materials to help clients bring transformative products to market. Nano Terra also addresses critical challenges in national defense and human health through its work in diagnostics and counterfeit detection.

SIONYX

Series B in 2010
SiOnyx, Inc. is a company based in Beverly, Massachusetts, specializing in the development and commercialization of advanced semiconductor processes that improve the infrared sensitivity of silicon-based photonics. Established in 2005, SiOnyx focuses on creating high-performance light sensing devices suitable for a variety of applications, including security, defense, consumer electronics, industrial use, medical technology, and automotive sectors. The company is recognized for its innovative XQE CMOS image sensors, which enable capabilities such as night vision, biometrics, eye-tracking, and natural human interfaces. Additionally, SiOnyx produces HD action video cameras that utilize its ultra-low-light image sensor technology, making digital night vision more accessible across various industries.

GEO Semiconductor

Debt Financing in 2010
Geo Semiconductor Inc. develops and distributes advanced video processors primarily for automotive viewing cameras. The company specializes in geometric processing, image signal processing, and video compression technologies, which enhance camera and projection products. Its offerings include systems-on-chip for geometry and image processing, along with evaluation boards for video system design. The products are utilized in various applications such as automotive cameras, head-up displays, security cameras, projectors, and consumer electronics. Geo Semiconductor serves multiple markets, including automotive, consumer electronics, security, and projection, distributing its solutions through representatives and distributors both in the United States and internationally. Founded in 2009, the company is headquartered in San Jose, California, with additional operations in Toronto, Orlando, and Bengaluru.

Laser Light Engines

Series B in 2010
Laser Light Engines, Inc. specializes in the design, development, and manufacturing of digitally controlled laser-driven light engines intended for illumination applications. Established in 2008 and headquartered in Salem, New Hampshire, the company focuses on advancing laser illumination technologies that enhance digital projection. By replacing traditional lamps, Laser Light Engines delivers significantly brighter colors and sharper images, while also reducing energy consumption and operational costs. This innovation allows clients to achieve superior projected images, marking a notable improvement in projection quality.

Adesto Technologies

Venture Round in 2010
Adesto Technologies is a prominent provider of application-specific semiconductors and embedded systems tailored for Internet of Things (IoT) applications. The company serves over 5,000 customers globally, offering a diverse range of technologies that support industrial, consumer, medical, and communications markets. Adesto's products are designed to enhance the performance and cost-effectiveness of connected IoT devices, which include smart utility meters, wearable fitness trackers, medical monitors, and home automation systems. The company's extensive portfolio features IoT edge servers, routers, network nodes, communication modules, and various memory technologies. In addition to hardware, Adesto provides software, development kits, and system solutions to facilitate faster market entry for its clients. By leveraging their expertise and proprietary intellectual property, Adesto enables customers to create innovative and reliable IoT solutions, ultimately leading to improved efficiency and lower operational costs.

Contour Energy

Series B in 2010
Contour Energy is a company of portable power that commercializes customizable battery technologies for a wide range of cross-industry applications. It designs its next-generation battery systems to deliver unprecedented improvements in energy and power density, and are capable of performing in extreme operating conditions at significantly improved costs. Founded through the collaboration of Caltech and CNRS, the French National Center for Scientific Research, It combines expertise in nano-materials science, patented fluorine-based battery chemistries and manufacturing processes to significantly advance the state of portable power. With its headquarters in Azusa in California, a team of battery industry leaders from Caltech, Energizer, General Electric, Hewlett-Packard, Sanyo and Valence Technologies manages it. Private entrepreneurs hold it.

BridgeLux

Series D in 2010
Bridgelux, Inc. is a developer and manufacturer of solid-state lighting technologies based in Fremont, California. Established in 2002, the company specializes in high-power, energy-efficient light-emitting diode (LED) solutions, offering a diverse range of products including LED arrays, chips, subsystems, and surface mounts. Its product lineup encompasses various applications, such as downlights, streetlights, and replacement lamps, serving sectors like retail, healthcare, and industrial environments. Bridgelux aims to replace traditional lighting technologies with its sustainable and cost-effective solutions, contributing to global energy efficiency efforts. The company also provides testing, application engineering, and reference design services to support its clients. In addition to its headquarters, Bridgelux has strategic partnerships and additional locations globally, enhancing its market reach and technological innovation. The company was previously known as eLite Optoelectronics, Inc. before rebranding in April 2006.

Innovalight

Series D in 2010
Innovalight, founded by Conrad Burke, specializes in the development of high-efficiency, low-cost solar modules utilizing innovative silicon-based technology. The company has created a unique silicon ink, which has been in development since 2005, enabling a shift in manufacturing processes by employing liquid-based processing instead of traditional solid or gas methods. This approach aims to significantly enhance the cost-effectiveness and efficiency of solar modules. Innovalight's products are designed for both residential and commercial applications, focusing on ultra thin-film power modules to support grid-connected solar power generation.

Metabolon

Series C in 2009
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

Laser Light Engines

Debt Financing in 2009
Laser Light Engines, Inc. specializes in the design, development, and manufacturing of digitally controlled laser-driven light engines intended for illumination applications. Established in 2008 and headquartered in Salem, New Hampshire, the company focuses on advancing laser illumination technologies that enhance digital projection. By replacing traditional lamps, Laser Light Engines delivers significantly brighter colors and sharper images, while also reducing energy consumption and operational costs. This innovation allows clients to achieve superior projected images, marking a notable improvement in projection quality.

Metabolon

Series C in 2009
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

Innovalight

Venture Round in 2009
Innovalight, founded by Conrad Burke, specializes in the development of high-efficiency, low-cost solar modules utilizing innovative silicon-based technology. The company has created a unique silicon ink, which has been in development since 2005, enabling a shift in manufacturing processes by employing liquid-based processing instead of traditional solid or gas methods. This approach aims to significantly enhance the cost-effectiveness and efficiency of solar modules. Innovalight's products are designed for both residential and commercial applications, focusing on ultra thin-film power modules to support grid-connected solar power generation.

Solazyme

Series D in 2009
Solazyme is a synthetic biology company that specializes in converting algal biomass into biofuels. Solazyme not only creates biofuels for the the transportation industry, but is experimenting with ways to tailor its products for the cosmetic and food industries.

Contour Energy

Series A in 2008
Contour Energy is a company of portable power that commercializes customizable battery technologies for a wide range of cross-industry applications. It designs its next-generation battery systems to deliver unprecedented improvements in energy and power density, and are capable of performing in extreme operating conditions at significantly improved costs. Founded through the collaboration of Caltech and CNRS, the French National Center for Scientific Research, It combines expertise in nano-materials science, patented fluorine-based battery chemistries and manufacturing processes to significantly advance the state of portable power. With its headquarters in Azusa in California, a team of battery industry leaders from Caltech, Energizer, General Electric, Hewlett-Packard, Sanyo and Valence Technologies manages it. Private entrepreneurs hold it.

Tetravitae Biosciences

Series A in 2008
TetraVitae Bioscience is focused on developing biobased chemicals, plastics, and fuels using bio-butanol derived from biomass substrates through microbial fermentation. The company employs proprietary technology and expertise in industrial fermentations, process engineering, microbiology, and the utilization of cellulosic feedstocks. This innovative approach aims to significantly reduce production costs, enabling TetraVitae to compete with and potentially replace traditional petroleum-derived products. Additionally, the company operates a microbiological laboratory to support its research and development efforts in this field.

Cobalt Technologies

Series C in 2008
Cobalt Technologies is a company focused on developing innovative technologies for biofuels, particularly in the production of bio-based chemicals. Founded in 2005 and headquartered in Mountain View, California, Cobalt is pioneering methods to produce low-cost, commercial-scale biobutanol, an alternative to traditional petroleum-based products. This next-generation bio n-butanol serves as an ingredient in various applications, including fuels, bio-based plastics, synthetic rubber, paints, adhesives, and solvents. By offering cost-effective substitutes to petroleum-derived chemicals, Cobalt aims to create fuels that burn cleaner and have a reduced environmental impact.

Solazyme

Series C in 2008
Solazyme is a synthetic biology company that specializes in converting algal biomass into biofuels. Solazyme not only creates biofuels for the the transportation industry, but is experimenting with ways to tailor its products for the cosmetic and food industries.

Nextreme Thermal Solutions

Series B in 2008
Nextreme designs and manufactures micro-scale thermal and power management products for the semiconductor, photonics, consumer, automotive and defense/aerospace industries. The company has embedded cooling and power generation capabilities into the widely accepted copper pillar bumping process used in high-volume electronic packaging. Nextreme’s breakthrough addresses the most challenging thermal and power management constraints in electronics today, and delivers the only fully-scalable technology solution by leveraging the existing, high-volume flip chip manufacturing infrastructure. By minimizing the need for manufacturing changes and focusing on developing a seamless design-in solution, Nextreme is changing the future of thermal and power management for the entire electronics industry.

Laser Light Engines

Series A in 2008
Laser Light Engines, Inc. specializes in the design, development, and manufacturing of digitally controlled laser-driven light engines intended for illumination applications. Established in 2008 and headquartered in Salem, New Hampshire, the company focuses on advancing laser illumination technologies that enhance digital projection. By replacing traditional lamps, Laser Light Engines delivers significantly brighter colors and sharper images, while also reducing energy consumption and operational costs. This innovation allows clients to achieve superior projected images, marking a notable improvement in projection quality.

Adesto Technologies

Series A in 2008
Adesto Technologies is a prominent provider of application-specific semiconductors and embedded systems tailored for Internet of Things (IoT) applications. The company serves over 5,000 customers globally, offering a diverse range of technologies that support industrial, consumer, medical, and communications markets. Adesto's products are designed to enhance the performance and cost-effectiveness of connected IoT devices, which include smart utility meters, wearable fitness trackers, medical monitors, and home automation systems. The company's extensive portfolio features IoT edge servers, routers, network nodes, communication modules, and various memory technologies. In addition to hardware, Adesto provides software, development kits, and system solutions to facilitate faster market entry for its clients. By leveraging their expertise and proprietary intellectual property, Adesto enables customers to create innovative and reliable IoT solutions, ultimately leading to improved efficiency and lower operational costs.

BridgeLux

Series D in 2008
Bridgelux, Inc. is a developer and manufacturer of solid-state lighting technologies based in Fremont, California. Established in 2002, the company specializes in high-power, energy-efficient light-emitting diode (LED) solutions, offering a diverse range of products including LED arrays, chips, subsystems, and surface mounts. Its product lineup encompasses various applications, such as downlights, streetlights, and replacement lamps, serving sectors like retail, healthcare, and industrial environments. Bridgelux aims to replace traditional lighting technologies with its sustainable and cost-effective solutions, contributing to global energy efficiency efforts. The company also provides testing, application engineering, and reference design services to support its clients. In addition to its headquarters, Bridgelux has strategic partnerships and additional locations globally, enhancing its market reach and technological innovation. The company was previously known as eLite Optoelectronics, Inc. before rebranding in April 2006.

Metabolon

Series C in 2008
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

PolyRemedy

Series B in 2008
PolyRemedy offers integrated wound management systems designed to increase consistency by extending wound care expertise to the point of care. The PolyRemedy Personalized Woundcare System (PWS) enables clinicians to document care through easy-to-use, web-based assessment tools and order personalized wound dressings, while also providing critical and unprecedented visibility into wound care data. It was founded in 2004 and is headquartered in Concord, Massachusetts.

D-Wave Systems

Series C in 2008
D-Wave Systems Inc. specializes in the development and integration of superconducting quantum computers. As the first commercial supplier of quantum computers, the company offers products such as The D-Wave Two System, D-Wave Hybrid—a hybrid workflow platform for quantum-classical applications—and Leap, a cloud-based service that enables real-time access to quantum computing resources along with open-source development tools and educational materials. D-Wave's quantum computers are applied across various sectors, including defense, finance, energy, and academia, addressing challenges in mission planning, logistics, machine learning, optimization problems, and more. In addition to its quantum computing systems, the company provides professional services, training, and customer support to enhance user experience. Founded in 1999 and headquartered in Burnaby, Canada, D-Wave has expanded its presence with sales offices in the United States, Europe, and Asia.

Ensemble Discovery

Series B in 2007
Ensemble Discovery is developing a new class of therapeutics - the Ensemblinsâ„¢, orally bioavailable small molecule macrocyclic compounds that have the potential to behave like biologics and can disrupt protein-protein interactions. They have two complementary platforms that provide access to these molecules. Firstly, they use their proprietary DNA-Programmed Chemistryâ„¢ (DPCâ„¢) platform to generate hundreds of thousands of these molecules for rapid screening. Secondly, they have highly developed methods for the synthesis of Ensemblins as discrete molecules using conventional chemistry.

Innovalight

Series C in 2007
Innovalight, founded by Conrad Burke, specializes in the development of high-efficiency, low-cost solar modules utilizing innovative silicon-based technology. The company has created a unique silicon ink, which has been in development since 2005, enabling a shift in manufacturing processes by employing liquid-based processing instead of traditional solid or gas methods. This approach aims to significantly enhance the cost-effectiveness and efficiency of solar modules. Innovalight's products are designed for both residential and commercial applications, focusing on ultra thin-film power modules to support grid-connected solar power generation.

SIONYX

Series A in 2007
SiOnyx, Inc. is a company based in Beverly, Massachusetts, specializing in the development and commercialization of advanced semiconductor processes that improve the infrared sensitivity of silicon-based photonics. Established in 2005, SiOnyx focuses on creating high-performance light sensing devices suitable for a variety of applications, including security, defense, consumer electronics, industrial use, medical technology, and automotive sectors. The company is recognized for its innovative XQE CMOS image sensors, which enable capabilities such as night vision, biometrics, eye-tracking, and natural human interfaces. Additionally, SiOnyx produces HD action video cameras that utilize its ultra-low-light image sensor technology, making digital night vision more accessible across various industries.

Chlorogen

Venture Round in 2007
Chlorogen a biopharmaceutical company, engages in the development and manufacture of proteins for human therapy. The company, through its chloroplast transformation technology (CTT), offers plant made drugs for the treatment and prevention of human diseases, as well as for treatment of women's reproductive cancers. Its products include therapeutic proteins in tobacco that are made using chloroplast transformation technology. The chloroplast transformation technology facilitates hyper-expression of recombinant proteins in tobacco chloroplasts. The company offers its chloroplast-tobacco platform for commercial use in food and agriculture. Chlorogen, Inc. was founded in 2002 and is based in St. Louis, Missouri.

Kovio

Series D in 2007
Kovio Inc. is a privately held company based in Silicon Valley that specializes in the development of printed silicon products. Utilizing innovative manufacturing techniques that merge graphics printing with silicon-based semiconductor technology, Kovio produces low-cost solutions for various applications. The company focuses on markets such as Near Field Communication (NFC) and Electronic Article Surveillance (EAS), designing and manufacturing products like Radio Frequency Identification (RFID) tags and NFC Barcodes. Founded in the MIT Media Laboratory, Kovio aims to create a new category of semiconductor products that leverage the advantages of printed electronics.

BridgeLux

Series C in 2007
Bridgelux, Inc. is a developer and manufacturer of solid-state lighting technologies based in Fremont, California. Established in 2002, the company specializes in high-power, energy-efficient light-emitting diode (LED) solutions, offering a diverse range of products including LED arrays, chips, subsystems, and surface mounts. Its product lineup encompasses various applications, such as downlights, streetlights, and replacement lamps, serving sectors like retail, healthcare, and industrial environments. Bridgelux aims to replace traditional lighting technologies with its sustainable and cost-effective solutions, contributing to global energy efficiency efforts. The company also provides testing, application engineering, and reference design services to support its clients. In addition to its headquarters, Bridgelux has strategic partnerships and additional locations globally, enhancing its market reach and technological innovation. The company was previously known as eLite Optoelectronics, Inc. before rebranding in April 2006.

Xradia

Series D in 2007
Xradia develops technology to help advance innovation in science and industry by providing unique insight through superior X-ray imaging solutions. Our products utilize advanced X-ray computed tomography (CT) imaging methodology and optics to nondestructively produce 3D images of objects with exceptional spatial resolution and contrast. Xradia's technology is based on proprietary X-ray optics and detectors. Xradia produces state-of-the-art far-field ambient environment imaging systems capable of 3D imaging with resolution below 50 nm. Xradia's commercial products have 3D resolution from the nanometer level up to several hundred microns.

Crystal IS

Series B in 2006
Crystal IS specializes in the production of ultraviolet light emitting diodes (UV LEDs) utilizing single-crystal aluminum nitride (AlN) substrate technology. As a leader in this field, the company focuses on creating high-performance UVC LEDs designed for water, surface, and air purification applications. Their products cater to a wide range of sectors, including consumer and commercial appliances, medical devices, and life sciences. By emphasizing energy efficiency and durability, Crystal IS enables its clients to enhance their production with effective disinfection solutions.

SIONYX

Series A in 2006
SiOnyx, Inc. is a company based in Beverly, Massachusetts, specializing in the development and commercialization of advanced semiconductor processes that improve the infrared sensitivity of silicon-based photonics. Established in 2005, SiOnyx focuses on creating high-performance light sensing devices suitable for a variety of applications, including security, defense, consumer electronics, industrial use, medical technology, and automotive sectors. The company is recognized for its innovative XQE CMOS image sensors, which enable capabilities such as night vision, biometrics, eye-tracking, and natural human interfaces. Additionally, SiOnyx produces HD action video cameras that utilize its ultra-low-light image sensor technology, making digital night vision more accessible across various industries.

NanoOpto

Series D in 2006
NanoOpto specializes in the design and manufacturing of integrated modular nano-optic components for optical systems and networks. Utilizing proprietary nano-optics and nano-manufacturing technology, the company offers a range of products, including IR cut filters, nano-optic isolators, deep ultraviolet polarizers, polarizing beam splitters, optical isolators, microlens arrays, and WDM filters, along with waveplates and trim retarders. With a focus on rapid prototyping and high performance, NanoOpto's innovative techniques enable the production of superior conventional optical components and the development of new integrated components. The company also provides services such as conformal optical coatings, precision coatings, precision dicing, and optical design and engineering. Operating from its facility in Somerset, New Jersey, NanoOpto aims to lower overall system costs while enhancing optical capabilities through its advanced manufacturing processes.

NeoPhotonics

Series C in 2006
NeoPhotonics is a technology company specializing in the development, manufacture, and sale of optical components and subsystems used in high-speed digital communications networks. The company offers a comprehensive range of active and passive optical products tailored for various market segments, including fiber-to-the-home (FTTH), data communications, storage area networks, and both metro and long-haul networks. Its product lineup includes transceivers, integrated splitters, multiplexers, and advanced optical modules, all designed to support a wide array of data rates and applications. Notably, NeoPhotonics is recognized for its innovative silica Planar Lightwave Circuit (PLC) technology, which plays a crucial role in modern optical networks. Additionally, the company produces MEMS-based Variable Optical Attenuators and Dynamic Channel Equalizers, enhancing the performance and efficiency of communication systems.

Cswitch

Series B in 2006
Cswitch specializes in developing system-on-a-chip semiconductors tailored for networking-based platforms. Founded by a team of experienced semiconductor executives, the company leverages their extensive background in advanced processors and ASIC development to create innovative configurable solutions. In addition to semiconductors, Cswitch provides design tools for configurable switch array devices and offers development and validation boards that facilitate the design and verification of various networking applications. Their focus spans multiple markets, including networking, telecommunications, storage, and wireless base stations, enabling them to address a wide range of industry needs.

D-Wave Systems

Series B in 2006
D-Wave Systems Inc. specializes in the development and integration of superconducting quantum computers. As the first commercial supplier of quantum computers, the company offers products such as The D-Wave Two System, D-Wave Hybrid—a hybrid workflow platform for quantum-classical applications—and Leap, a cloud-based service that enables real-time access to quantum computing resources along with open-source development tools and educational materials. D-Wave's quantum computers are applied across various sectors, including defense, finance, energy, and academia, addressing challenges in mission planning, logistics, machine learning, optimization problems, and more. In addition to its quantum computing systems, the company provides professional services, training, and customer support to enhance user experience. Founded in 1999 and headquartered in Burnaby, Canada, D-Wave has expanded its presence with sales offices in the United States, Europe, and Asia.

Innovalight

Series B in 2006
Innovalight, founded by Conrad Burke, specializes in the development of high-efficiency, low-cost solar modules utilizing innovative silicon-based technology. The company has created a unique silicon ink, which has been in development since 2005, enabling a shift in manufacturing processes by employing liquid-based processing instead of traditional solid or gas methods. This approach aims to significantly enhance the cost-effectiveness and efficiency of solar modules. Innovalight's products are designed for both residential and commercial applications, focusing on ultra thin-film power modules to support grid-connected solar power generation.

Cswitch

Series B in 2006
Cswitch specializes in developing system-on-a-chip semiconductors tailored for networking-based platforms. Founded by a team of experienced semiconductor executives, the company leverages their extensive background in advanced processors and ASIC development to create innovative configurable solutions. In addition to semiconductors, Cswitch provides design tools for configurable switch array devices and offers development and validation boards that facilitate the design and verification of various networking applications. Their focus spans multiple markets, including networking, telecommunications, storage, and wireless base stations, enabling them to address a wide range of industry needs.

BridgeLux

Venture Round in 2006
Bridgelux, Inc. is a developer and manufacturer of solid-state lighting technologies based in Fremont, California. Established in 2002, the company specializes in high-power, energy-efficient light-emitting diode (LED) solutions, offering a diverse range of products including LED arrays, chips, subsystems, and surface mounts. Its product lineup encompasses various applications, such as downlights, streetlights, and replacement lamps, serving sectors like retail, healthcare, and industrial environments. Bridgelux aims to replace traditional lighting technologies with its sustainable and cost-effective solutions, contributing to global energy efficiency efforts. The company also provides testing, application engineering, and reference design services to support its clients. In addition to its headquarters, Bridgelux has strategic partnerships and additional locations globally, enhancing its market reach and technological innovation. The company was previously known as eLite Optoelectronics, Inc. before rebranding in April 2006.

NanoGram

Venture Round in 2006
NanoGram Corporation is a nanotechnology company focused on developing and manufacturing advanced products for photovoltaics, electronics, and displays. It offers a customized application-specific nanotechnology platform that produces nanoscale compositions for various sectors, including optical, electronic, imaging, biomedical, and energy applications. The company has successfully incubated and spun out two firms, NeoPhotonics and NanoGram Devices. With a presence in Japan through its Tokyo office and a strategic partnership with Nagase & Co., Ltd / Nagase ChemteX Corporation, NanoGram is expanding its footprint in the region. Additionally, its office in Seoul, South Korea, supports its growth in the Korean market.

Metabolon

Series B in 2006
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

Kovio

Venture Round in 2005
Kovio Inc. is a privately held company based in Silicon Valley that specializes in the development of printed silicon products. Utilizing innovative manufacturing techniques that merge graphics printing with silicon-based semiconductor technology, Kovio produces low-cost solutions for various applications. The company focuses on markets such as Near Field Communication (NFC) and Electronic Article Surveillance (EAS), designing and manufacturing products like Radio Frequency Identification (RFID) tags and NFC Barcodes. Founded in the MIT Media Laboratory, Kovio aims to create a new category of semiconductor products that leverage the advantages of printed electronics.

Mersana Therapeutics

Venture Round in 2005
Mersana Therapeutics is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, specializing in the development of antibody-drug conjugates (ADCs) for cancer treatment. The company utilizes its proprietary biodegradable polymer platform, Dolaflexin, to create a pipeline of ADC product candidates aimed at addressing oncology indications with significant unmet needs. Its lead candidate, XMT-1536, is currently in Phase I clinical trials targeting NaPi2b for the treatment of ovarian cancer, non-small cell lung cancer, and other rare conditions. Mersana is also advancing additional candidates, including XMT-1660, targeting B7-H4, and XMT-2056, a STING agonist ADC, both designed to improve tolerability and therapeutic outcomes. The company has established strategic partnerships with Merck KGaA and Asana BioSciences to further develop its ADC candidates. Founded in 2005, Mersana Therapeutics aims to deliver innovative treatments to patients through its advanced research and development efforts.

Molecular Imprints

Series C in 2005
Molecular Imprints Inc., founded in 2001 and based in Austin, Texas, specializes in manufacturing imprint and lithography systems designed for creating nanometer-scale surface relief structures. The company is recognized for its Jet and Flash imprint lithography technology, which offers advanced nanopatterning capabilities for various high-tech industries, including displays, life sciences, and light-emitting diodes. With a robust intellectual property portfolio, Molecular Imprints has applied for over 700 patents, resulting in more than 100 issued patents that encompass imprint tools, materials, and process technology. The core of its technology, the Jet and Flash Imprint Lithography, employs the IntelliJet Drop Pattern Generator to achieve precise placement of photoresist on substrates in extremely small volumes, facilitating the uniform imprinting of features down to 10 nanometers and below. Through a combination of specialized competencies and strategic partnerships, Molecular Imprints delivers innovative solutions that meet the demanding needs of its customers.

Chlorogen

Series B in 2005
Chlorogen a biopharmaceutical company, engages in the development and manufacture of proteins for human therapy. The company, through its chloroplast transformation technology (CTT), offers plant made drugs for the treatment and prevention of human diseases, as well as for treatment of women's reproductive cancers. Its products include therapeutic proteins in tobacco that are made using chloroplast transformation technology. The chloroplast transformation technology facilitates hyper-expression of recombinant proteins in tobacco chloroplasts. The company offers its chloroplast-tobacco platform for commercial use in food and agriculture. Chlorogen, Inc. was founded in 2002 and is based in St. Louis, Missouri.

NeoPhotonics

Venture Round in 2005
NeoPhotonics is a technology company specializing in the development, manufacture, and sale of optical components and subsystems used in high-speed digital communications networks. The company offers a comprehensive range of active and passive optical products tailored for various market segments, including fiber-to-the-home (FTTH), data communications, storage area networks, and both metro and long-haul networks. Its product lineup includes transceivers, integrated splitters, multiplexers, and advanced optical modules, all designed to support a wide array of data rates and applications. Notably, NeoPhotonics is recognized for its innovative silica Planar Lightwave Circuit (PLC) technology, which plays a crucial role in modern optical networks. Additionally, the company produces MEMS-based Variable Optical Attenuators and Dynamic Channel Equalizers, enhancing the performance and efficiency of communication systems.

NanoOpto

Series C in 2005
NanoOpto specializes in the design and manufacturing of integrated modular nano-optic components for optical systems and networks. Utilizing proprietary nano-optics and nano-manufacturing technology, the company offers a range of products, including IR cut filters, nano-optic isolators, deep ultraviolet polarizers, polarizing beam splitters, optical isolators, microlens arrays, and WDM filters, along with waveplates and trim retarders. With a focus on rapid prototyping and high performance, NanoOpto's innovative techniques enable the production of superior conventional optical components and the development of new integrated components. The company also provides services such as conformal optical coatings, precision coatings, precision dicing, and optical design and engineering. Operating from its facility in Somerset, New Jersey, NanoOpto aims to lower overall system costs while enhancing optical capabilities through its advanced manufacturing processes.

Nanomix

Series C in 2005
Nanomix, Inc. develops automated point-of-care diagnostic systems designed to deliver rapid and actionable diagnostic information. The company's flagship product, the Nanōmix eLab® System, features a handheld reader and an integrated assay cartridge with a proprietary biosensor, enabling assays to provide results in 10 minutes or less. This system is particularly useful for critical care settings, allowing for timely diagnosis of conditions such as sepsis and cardiac issues within crucial clinical windows. The eLab platform supports multiple in-vitro diagnostic and enzymatic assays from a single whole-blood sample, enhancing its utility in various healthcare environments. Founded in 2000 and based in Emeryville, California, Nanomix aims to reduce healthcare system costs while improving patient outcomes through its innovative mobile diagnostics solutions.

Nextreme Thermal Solutions

Series A in 2005
Nextreme designs and manufactures micro-scale thermal and power management products for the semiconductor, photonics, consumer, automotive and defense/aerospace industries. The company has embedded cooling and power generation capabilities into the widely accepted copper pillar bumping process used in high-volume electronic packaging. Nextreme’s breakthrough addresses the most challenging thermal and power management constraints in electronics today, and delivers the only fully-scalable technology solution by leveraging the existing, high-volume flip chip manufacturing infrastructure. By minimizing the need for manufacturing changes and focusing on developing a seamless design-in solution, Nextreme is changing the future of thermal and power management for the entire electronics industry.

Nantero

Series C in 2005
Nantero, Inc. is a nanotechnology company based in Woburn, Massachusetts, that specializes in the development of semiconductor products utilizing carbon nanotubes. Founded in 2001, Nantero focuses on creating nonvolatile random access memory (NRAM) chips, which provide high-density, high-speed storage solutions for a variety of applications, including smartphones, tablets, computers, and industrial systems. The company's NRAM technology offers advantages over traditional memory types, such as zero power consumption in standby mode, making it suitable for both standalone and embedded memory applications. In addition to NRAM, Nantero produces nanoelectromechanical switches and other semiconductor products, and collaborates with licensees to expand the use of its nanotube-based technology across various sectors.

Cambrios Technologies

Series B in 2005
Cambrios Technologies Corporation specializes in developing and manufacturing advanced electronic materials, particularly electrodes made from silver nanowires. These materials simplify the manufacturing processes for electronic devices while enhancing their performance. The company's flagship product, ClearOhm, consists of silver nanowire coating materials that create transparent conducting layers on various substrates. This technology is applicable to a wide range of products, including touch screens, liquid crystal displays, e-paper, organic light-emitting diodes (OLED), and thin film photovoltaics. Founded in 2002 as Semzyme, Inc., the company rebranded to Cambrios Technologies Corporation in 2004 and is headquartered in Sunnyvale, California, with additional offices in Japan and Taiwan. Cambrios aims to leverage its nanostructured materials to improve the efficiency and capabilities of next-generation consumer devices.

Solazyme

Seed Round in 2004
Solazyme is a synthetic biology company that specializes in converting algal biomass into biofuels. Solazyme not only creates biofuels for the the transportation industry, but is experimenting with ways to tailor its products for the cosmetic and food industries.

NanoGram

Series B in 2004
NanoGram Corporation is a nanotechnology company focused on developing and manufacturing advanced products for photovoltaics, electronics, and displays. It offers a customized application-specific nanotechnology platform that produces nanoscale compositions for various sectors, including optical, electronic, imaging, biomedical, and energy applications. The company has successfully incubated and spun out two firms, NeoPhotonics and NanoGram Devices. With a presence in Japan through its Tokyo office and a strategic partnership with Nagase & Co., Ltd / Nagase ChemteX Corporation, NanoGram is expanding its footprint in the region. Additionally, its office in Seoul, South Korea, supports its growth in the Korean market.

Cswitch

Series A in 2004
Cswitch specializes in developing system-on-a-chip semiconductors tailored for networking-based platforms. Founded by a team of experienced semiconductor executives, the company leverages their extensive background in advanced processors and ASIC development to create innovative configurable solutions. In addition to semiconductors, Cswitch provides design tools for configurable switch array devices and offers development and validation boards that facilitate the design and verification of various networking applications. Their focus spans multiple markets, including networking, telecommunications, storage, and wireless base stations, enabling them to address a wide range of industry needs.

Nanotechnologies

Venture Round in 2004
NovaCentrix is a leader in manufacturing tools that enable printed electronics technologies. State-of-the-artPulseForge® tools utilize photonic curing which is a cutting edge technology that dries, sinters, and anneals functional inks in milliseconds on low-temperature, flexible substrates such as paper and plastic. NovaCentrixis seeking collaborative partners and customers for our patented photonic curing tools. These tools process a wide array of depositions including but not limited to metallic, non-metallic and semiconductor-based inks, as well as PVD metals and metal oxides. An integrated material and tool simulation package, SimPulse™, enables rapid assessment of the photonic curing capabilities in combination to experimental results. NovaCentrix also offers high-performance and economical Metalon® and PChemconductive inks, including the innovative and award-winning ICI copper-oxide reduction inks which work optimally with PulseForge tools given the need for high temperature processing of inks on low temperature substrates. NovaCentrix possesses in-house inkjet, screen, and flexographic presses and provides customers with prototyping services.

Molecular Imprints

Series B in 2004
Molecular Imprints Inc., founded in 2001 and based in Austin, Texas, specializes in manufacturing imprint and lithography systems designed for creating nanometer-scale surface relief structures. The company is recognized for its Jet and Flash imprint lithography technology, which offers advanced nanopatterning capabilities for various high-tech industries, including displays, life sciences, and light-emitting diodes. With a robust intellectual property portfolio, Molecular Imprints has applied for over 700 patents, resulting in more than 100 issued patents that encompass imprint tools, materials, and process technology. The core of its technology, the Jet and Flash Imprint Lithography, employs the IntelliJet Drop Pattern Generator to achieve precise placement of photoresist on substrates in extremely small volumes, facilitating the uniform imprinting of features down to 10 nanometers and below. Through a combination of specialized competencies and strategic partnerships, Molecular Imprints delivers innovative solutions that meet the demanding needs of its customers.

Continuum Photonics

Series C in 2004
Continuum Photonics specializes in the development of optical layer connectivity products designed for managing and switching fiber-based optical networks. The company focuses on providing manufacturers of optical networking equipment with innovative subsystems that enhance bandwidth capabilities and facilitate revenue-generating services at reduced costs. Key offerings include single-mode and multi-mode optical matrix switches, carrier optical monitor switches, and latching switches. Continuum Photonics is also advancing a novel photonic switch aimed at addressing various challenges related to the delivery and management of optically-transported bandwidth, which underscores its commitment to creating operational and economic efficiencies in the optical networking sector.

NeoPhotonics

Series B in 2004
NeoPhotonics is a technology company specializing in the development, manufacture, and sale of optical components and subsystems used in high-speed digital communications networks. The company offers a comprehensive range of active and passive optical products tailored for various market segments, including fiber-to-the-home (FTTH), data communications, storage area networks, and both metro and long-haul networks. Its product lineup includes transceivers, integrated splitters, multiplexers, and advanced optical modules, all designed to support a wide array of data rates and applications. Notably, NeoPhotonics is recognized for its innovative silica Planar Lightwave Circuit (PLC) technology, which plays a crucial role in modern optical networks. Additionally, the company produces MEMS-based Variable Optical Attenuators and Dynamic Channel Equalizers, enhancing the performance and efficiency of communication systems.

NanoOpto

Series B in 2003
NanoOpto specializes in the design and manufacturing of integrated modular nano-optic components for optical systems and networks. Utilizing proprietary nano-optics and nano-manufacturing technology, the company offers a range of products, including IR cut filters, nano-optic isolators, deep ultraviolet polarizers, polarizing beam splitters, optical isolators, microlens arrays, and WDM filters, along with waveplates and trim retarders. With a focus on rapid prototyping and high performance, NanoOpto's innovative techniques enable the production of superior conventional optical components and the development of new integrated components. The company also provides services such as conformal optical coatings, precision coatings, precision dicing, and optical design and engineering. Operating from its facility in Somerset, New Jersey, NanoOpto aims to lower overall system costs while enhancing optical capabilities through its advanced manufacturing processes.

Nantero

Series B in 2003
Nantero, Inc. is a nanotechnology company based in Woburn, Massachusetts, that specializes in the development of semiconductor products utilizing carbon nanotubes. Founded in 2001, Nantero focuses on creating nonvolatile random access memory (NRAM) chips, which provide high-density, high-speed storage solutions for a variety of applications, including smartphones, tablets, computers, and industrial systems. The company's NRAM technology offers advantages over traditional memory types, such as zero power consumption in standby mode, making it suitable for both standalone and embedded memory applications. In addition to NRAM, Nantero produces nanoelectromechanical switches and other semiconductor products, and collaborates with licensees to expand the use of its nanotube-based technology across various sectors.

Nanogram Devices

Venture Round in 2003
NanoGram Devices Corporation is a nanotechnology company located in Milpitas, California, founded in 2002 by Jason Lemkin. The company specializes in the development of products utilizing nanomaterials to create power sources specifically for medical device applications.

Optiva

Series C in 2003
Optiva develops and manufactures nanomaterials for use in optical, electro-optical, and semiconductor applications.

Terion

Venture Round in 2002
Terion specializes in providing innovative solutions for the untethered trailer tracking market. The company has developed a unique system from the ground up, focusing on two-way wireless communication for mobile applications within the transportation sector. Terion, in partnership with Equipment Services, operates more than 100,000 tracking and monitoring units on over-the-road trailers across the United States and Europe, enhancing visibility and efficiency in trailer management.

Continuum Photonics

Series B in 2002
Continuum Photonics specializes in the development of optical layer connectivity products designed for managing and switching fiber-based optical networks. The company focuses on providing manufacturers of optical networking equipment with innovative subsystems that enhance bandwidth capabilities and facilitate revenue-generating services at reduced costs. Key offerings include single-mode and multi-mode optical matrix switches, carrier optical monitor switches, and latching switches. Continuum Photonics is also advancing a novel photonic switch aimed at addressing various challenges related to the delivery and management of optically-transported bandwidth, which underscores its commitment to creating operational and economic efficiencies in the optical networking sector.

Nantero

Series A in 2001
Nantero, Inc. is a nanotechnology company based in Woburn, Massachusetts, that specializes in the development of semiconductor products utilizing carbon nanotubes. Founded in 2001, Nantero focuses on creating nonvolatile random access memory (NRAM) chips, which provide high-density, high-speed storage solutions for a variety of applications, including smartphones, tablets, computers, and industrial systems. The company's NRAM technology offers advantages over traditional memory types, such as zero power consumption in standby mode, making it suitable for both standalone and embedded memory applications. In addition to NRAM, Nantero produces nanoelectromechanical switches and other semiconductor products, and collaborates with licensees to expand the use of its nanotube-based technology across various sectors.

Informio

Series A in 2000
Informio,Inc trial service delivers Internet content and voice applications through any wireless phone. It has been developed by people who pioneered voice messaging systems and the World Wide Web. Find out about what they're doing by subscribing to their mailing list.

Nanophase Technologies

Series D in 1994
Nanophase Technologies Corporation, established in 1989 and headquartered in Romeoville, Illinois, specializes in the production of engineered nanomaterials for diverse applications. The company offers surface-engineered zinc oxide and titanium dioxide primarily for sunscreens and personal care products, along with fully formulated cosmetics under the Solésence brand. Its advanced materials include architectural and industrial coatings, abrasion-resistant additives, and medical diagnostics. Additionally, Nanophase Technologies provides coated nanoparticles and dispersions utilized across various markets, including energy and surface finishing technologies. By leveraging integrated nanomaterial technologies, the company aims to deliver tailored solutions to meet the specific needs of its customers in multiple industries.
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