180 Degree Capital

180 Degree Capital is an investment firm located in Montclair, New Jersey, specializing in a range of sectors including technology, nanotechnology, energy, clean technology, healthcare, and electronics. Established in 1981, the firm is recognized as a proactive investor in small technology companies, focusing on those that develop innovative nanoscale-enabled solutions across various applications such as solid state lighting, memory devices, and life sciences. 180 Degree Capital often collaborates with other venture capital firms and strategic investors, positioning itself as a lead investor in many cases. The firm adheres to a traditional early-stage venture capital model, seeking to support technology-based startups through its extensive network, technical expertise, and financial resources. It prioritizes investments in companies that demonstrate strong scientific, technological, and business capabilities, particularly those with proprietary technologies and market-centric strategies aimed at dominating significant product categories. Though primarily focused on the United States, the firm has occasionally explored international investments.

Alexei Andreev

Executive Vice President and Managing Director

Charles E. Harris

Chairman and CEO

98 past transactions

EchoPixel

Series A in 2017
EchoPixel, Inc. is a medical visualization software company that specializes in three-dimensional imaging technology. Established in 2012 and based in California, EchoPixel develops advanced solutions that allow medical professionals to interact with patient-specific organs and tissues in a virtual reality environment. Its flagship product, the True 3D Viewer, provides a real-time, interactive platform for evaluating and dissecting anatomical structures, enhancing the diagnostic process. Additionally, the company offers the True 3D Medical Education Viewer, which aids medical students in understanding three-dimensional anatomy through computer tomography and magnetic resonance images. EchoPixel also focuses on non-invasive diagnostic tools, including a colon cancer screening solution that utilizes computed tomography images to create a detailed 3D model of the colon, allowing healthcare providers to detect polyps and other abnormalities effectively.

NGX Bio

Venture Round in 2017
NGX Bio is an online marketplace that simplifies access to DNA sequencing services for researchers worldwide. The company connects customers with top-tier genomic resources, facilitating the completion of sequencing projects in a single transaction. By sourcing providers with available capacity, NGX Bio enhances cost-effectiveness and efficiency in project execution. The platform offers a comprehensive range of services, including design and planning, sample preparation, sequencing, and data analysis. Additionally, NGX Bio features an online project management tool that aids in sample tracking through the use of barcoded tubes and plates. This integrated approach ensures that clients receive high-quality, rapid, and affordable sequencing solutions tailored to their specific needs.

ORIG3N

Venture Round in 2017
ORIG3N, Inc. is a biotechnology company focused on developing innovative treatments for rare genetically inherited diseases, particularly targeting conditions related to the heart, liver, and neurodegeneration. Founded in 2014 and based in Boston, Massachusetts, ORIG3N utilizes induced pluripotent stem cell technology that allows for the differentiation of cells into any type found in the body. This technology is employed to test drug efficacy, screen for medication toxicity, and create personalized treatment pathways. The company offers a range of products, including LifeProfiles, which provides genetic insights related to fitness, metabolism, and exercise recovery; the Run DNA test for optimizing running performance; AURA, which assesses skin health; and Life Capsule, a repository for blood cells aimed at regenerative medicine development.

Lodo Therapeutics

Series A in 2016
Lodo Therapeutics Corporation is a drug discovery and development company dedicated to creating novel therapeutics derived from natural sources. It focuses on addressing significant health challenges, particularly resistant infectious diseases and cancers, by collaborating with global pharmaceutical companies and leading non-governmental organizations. Founded to realize the scientific vision of Dr. Sean Brady from Rockefeller University, Lodo Therapeutics utilizes a genome-based, culture-independent platform to discover and characterize small molecules sourced from environmental microbial DNA. This innovative approach leverages advancements in DNA sequencing and bioinformatics to explore the untapped potential of microbial evolution, aiming to identify therapeutically valuable pharmaceutical products. Headquartered in New York City at the Alexandria Center for Life Science, Lodo Therapeutics is committed to harnessing the power of nature in the fight against undruggable targets and high unmet medical needs.

TARA Biosystems

Seed Round in 2016
TARA Biosystems, Inc. is a biotechnology company that specializes in developing organ-on-a-chip technology for evaluating new therapies and drug compounds, particularly in the field of cardiac medicine. Founded in 2014 and based in the United States, the company produces predictive in vitro human cardiac tissue models derived from human stem cells. These models are matured to physiologically relevant adult-like levels, allowing for accurate measurement of cardiac functionality, including contractile force. TARA Biosystems focuses on enhancing drug discovery and safety assessment processes by providing high-fidelity solutions that enable faster and safer development of new medicines. By harnessing human biology and data, the company aims to transform cardiac drug discovery and improve patient health outcomes.

Petra Pharma

Series A in 2016
Petra Pharma Corporation is a clinical-stage pharmaceutical company based in New York, focused on discovering and developing innovative therapies that modulate phosphoinositide (PI) signaling pathways for the treatment of cancer and metabolic diseases. Founded in 2015, the company targets novel enzyme pathways that play crucial roles in various cellular processes, such as cell division, growth, trafficking, and signaling. By developing small molecules aimed at these processes, Petra Pharma seeks to create impactful therapeutic options that enhance patient care and improve health outcomes.

ORIG3N

Series A in 2015
ORIG3N, Inc. is a biotechnology company focused on developing innovative treatments for rare genetically inherited diseases, particularly targeting conditions related to the heart, liver, and neurodegeneration. Founded in 2014 and based in Boston, Massachusetts, ORIG3N utilizes induced pluripotent stem cell technology that allows for the differentiation of cells into any type found in the body. This technology is employed to test drug efficacy, screen for medication toxicity, and create personalized treatment pathways. The company offers a range of products, including LifeProfiles, which provides genetic insights related to fitness, metabolism, and exercise recovery; the Run DNA test for optimizing running performance; AURA, which assesses skin health; and Life Capsule, a repository for blood cells aimed at regenerative medicine development.

AgBiome

Series B in 2015
AgBiome, LLC is a biotechnology company based in Durham, North Carolina, that focuses on the agriculture industry through the development of biological products. Founded in 2012, AgBiome leverages its expertise in plant-associated microbes and modern genomics to create innovative solutions aimed at enhancing plant health, pest resistance, and crop yields. The company addresses critical agricultural challenges, including soil-borne diseases, insects, and nematodes, by offering fungicides and a platform that identifies and screens diverse microbial strains. AgBiome collaborates with prominent agricultural partners to accelerate discovery processes and broaden the reach of its sustainable products in global markets. With a dedicated team of over 85 employees and a state-of-the-art laboratory and greenhouse facility, AgBiome is committed to improving food production responsibly.

ORIG3N

Venture Round in 2015
ORIG3N, Inc. is a biotechnology company focused on developing innovative treatments for rare genetically inherited diseases, particularly targeting conditions related to the heart, liver, and neurodegeneration. Founded in 2014 and based in Boston, Massachusetts, ORIG3N utilizes induced pluripotent stem cell technology that allows for the differentiation of cells into any type found in the body. This technology is employed to test drug efficacy, screen for medication toxicity, and create personalized treatment pathways. The company offers a range of products, including LifeProfiles, which provides genetic insights related to fitness, metabolism, and exercise recovery; the Run DNA test for optimizing running performance; AURA, which assesses skin health; and Life Capsule, a repository for blood cells aimed at regenerative medicine development.

AgBiome

Venture Round in 2014
AgBiome, LLC is a biotechnology company based in Durham, North Carolina, that focuses on the agriculture industry through the development of biological products. Founded in 2012, AgBiome leverages its expertise in plant-associated microbes and modern genomics to create innovative solutions aimed at enhancing plant health, pest resistance, and crop yields. The company addresses critical agricultural challenges, including soil-borne diseases, insects, and nematodes, by offering fungicides and a platform that identifies and screens diverse microbial strains. AgBiome collaborates with prominent agricultural partners to accelerate discovery processes and broaden the reach of its sustainable products in global markets. With a dedicated team of over 85 employees and a state-of-the-art laboratory and greenhouse facility, AgBiome is committed to improving food production responsibly.

Enumeral Biomedical Holdings

Post in 2014
Enumeral Biomedical Holdings is a biotechnology company that focuses on developing innovative antibody immunotherapies aimed at enhancing the immune system's ability to combat diseased cells. Utilizing a microengraving process enabled by nanotechnology, the company explores opportunities in immunology, including therapeutic discovery, immune profiling, and personalized medicine. By extensively analyzing the human immune microenvironment, Enumeral enables physicians to identify and characterize new drugs relevant to cancer, infectious diseases, and inflammatory conditions. The company's mission is to address the needs of patients who are underserved in the diagnosis and treatment of these diverse health challenges.

NGX Bio

Seed Round in 2014
NGX Bio is an online marketplace that simplifies access to DNA sequencing services for researchers worldwide. The company connects customers with top-tier genomic resources, facilitating the completion of sequencing projects in a single transaction. By sourcing providers with available capacity, NGX Bio enhances cost-effectiveness and efficiency in project execution. The platform offers a comprehensive range of services, including design and planning, sample preparation, sequencing, and data analysis. Additionally, NGX Bio features an online project management tool that aids in sample tracking through the use of barcoded tubes and plates. This integrated approach ensures that clients receive high-quality, rapid, and affordable sequencing solutions tailored to their specific needs.

HZO

Series B in 2014
HZO specializes in protective nano and conformal coatings designed to safeguard electronic components in challenging environments. Founded in 2011 and headquartered in Morrisville, North Carolina, the company offers innovative water protection solutions tailored for electronics manufacturers. By utilizing advanced thin-film protective technology, including Parylene coatings, HZO enables manufacturers to create durable products capable of withstanding corrosive and liquid exposure. Its focus on nanotechnology and waterproofing allows for effective protection of electronic circuits and components, ensuring reliability in wet and harsh conditions.

Promuc

Venture Round in 2014
ProMuc, Inc. develops synthetic mucins for lubrication and antimicrobial applications.

Metabolon

Series E in 2014
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

ABSMaterials

Series B in 2013
ABS Materials designs, develops, and delivers solutions for ground, surface, and municipal water contamination. Its solutions include VoC-Eater system, which destroys pharmaceuticals, chlorinated solvents, herbicides, endocrine disruptors, PCBs, dyes, and phenols to outflow clean water; Osorb, a solution to destroy persistent organic pollutants in the groundwater; and Iron-Osorb, an inert sand-like glass used on TCE/PCE/DCE/PCBs. The company’s solutions are used to clean solvents, pesticides, and other persistent organic pollutants from the water, soil, and air. It offers its systems on a rental and long term lease basis. The company was founded in 2008 and is based in Wooster, Ohio with an additional office in Houston, Texas.

EchoPixel

Seed Round in 2013
EchoPixel, Inc. is a medical visualization software company that specializes in three-dimensional imaging technology. Established in 2012 and based in California, EchoPixel develops advanced solutions that allow medical professionals to interact with patient-specific organs and tissues in a virtual reality environment. Its flagship product, the True 3D Viewer, provides a real-time, interactive platform for evaluating and dissecting anatomical structures, enhancing the diagnostic process. Additionally, the company offers the True 3D Medical Education Viewer, which aids medical students in understanding three-dimensional anatomy through computer tomography and magnetic resonance images. EchoPixel also focuses on non-invasive diagnostic tools, including a colon cancer screening solution that utilizes computed tomography images to create a detailed 3D model of the colon, allowing healthcare providers to detect polyps and other abnormalities effectively.

AgBiome

Series A in 2013
AgBiome, LLC is a biotechnology company based in Durham, North Carolina, that focuses on the agriculture industry through the development of biological products. Founded in 2012, AgBiome leverages its expertise in plant-associated microbes and modern genomics to create innovative solutions aimed at enhancing plant health, pest resistance, and crop yields. The company addresses critical agricultural challenges, including soil-borne diseases, insects, and nematodes, by offering fungicides and a platform that identifies and screens diverse microbial strains. AgBiome collaborates with prominent agricultural partners to accelerate discovery processes and broaden the reach of its sustainable products in global markets. With a dedicated team of over 85 employees and a state-of-the-art laboratory and greenhouse facility, AgBiome is committed to improving food production responsibly.

Nantero

Series D in 2012
Nantero, Inc. is a nanotechnology company based in Woburn, Massachusetts, that specializes in the development of semiconductor products using carbon nanotubes. Founded in 2001, Nantero focuses on creating high-density, high-speed nonvolatile random access memory (NRAM) chips, which are designed for a range of applications including smartphones, tablets, enterprise systems, and automotive and industrial uses. The company's innovative memory technology offers advantages such as ultra-high density and zero power consumption in standby mode, making it a competitive alternative to traditional flash memory. In addition to NRAM, Nantero produces various semiconductor products, including nanoelectromechanical switches and memory and logic semiconductor products, while collaborating with licensees to explore additional applications of its core nanotube-based technology.

D-Wave Systems

Venture Round in 2012
D-Wave Systems Inc. is a pioneering company in the field of quantum computing, recognized as the world’s first commercial supplier of quantum computers. Founded in 1999 and headquartered in Burnaby, Canada, D-Wave specializes in the development, fabrication, and integration of superconducting quantum computers. The company offers a range of products, including the D-Wave Two System, a commercial quantum computer, and D-Wave Hybrid, an open-source platform for creating hybrid quantum-classical applications. Leap, its cloud-based service, provides real-time access to quantum computing resources along with development tools and educational content. D-Wave’s quantum computers are applied across various sectors, addressing challenges in mission planning, logistics, machine learning, and optimization problems, among others. The company serves diverse industries, including defense, finance, energy, and academia, and also offers professional services, training, and customer support to enhance user experience and application development.

Kovio

Venture Round in 2012
Kovio Inc. is a privately held company based in Silicon Valley that specializes in the development of innovative semiconductor products utilizing printed silicon electronics and thin film technology. Founded at the MIT Media Laboratory, Kovio focuses on creating low-cost manufacturing solutions that leverage the advantages of graphics printing alongside the capabilities of silicon-based semiconductors. The company designs, develops, and manufactures printed silicon products for various applications, particularly in the Near Field Communication (NFC) and Electronic Article Surveillance (EAS) markets. Its product offerings include Radio Frequency Identification (RFID) tags and NFC barcodes, positioning Kovio as a key player in the advancement of printed electronics.

OpGen

Series C in 2012
OpGen, Inc. is a precision medicine company focused on developing molecular diagnostics and informatics to address infectious diseases. Headquartered in Gaithersburg, Maryland, OpGen offers a range of products designed to provide clinicians with rapid and actionable information regarding life-threatening infections, ultimately aiming to enhance patient outcomes and reduce the spread of multidrug-resistant organisms (MDROs). Its key offerings include the Acuitas AMR Gene Panel, which detects bacterial nucleic acids and genetic markers of antimicrobial resistance, and the QuickFISH and PNA FISH products for pathogen identification in blood cultures. Additionally, OpGen provides the Acuitas Lighthouse informatics system, a cloud-based platform that integrates clinical lab results with patient and hospital data to support the management of antimicrobial-resistant infections. The company collaborates with the New York State Department of Health to develop solutions for detecting and tracking such infections in healthcare settings. Established in 2001, OpGen continues to innovate in addressing the critical challenge of antibiotic resistance through its advanced molecular microbiology solutions.

Senova Systems

Series B in 2012
Senova Systems, Inc. is a company based in Sunnyvale, California, that specializes in the development, manufacture, and sale of innovative pH measurement systems. Founded in 2007, Senova focuses on its patented calibration-free pHit™ pH sensor platform, which employs non-glass electrodes and features a wet-dry reversible design. This solid-state sensor technology represents a significant advancement in pH measurement, eliminating the need for user calibration and enabling novel applications across various sectors, including life sciences, food and beverage, dairy, water, and consumer products. By integrating advanced materials and proprietary microelectronics, Senova aims to enhance the precision and usability of pH sensors, paving the way for technological innovations previously unattainable with traditional glass electrodes.

BridgeLux

Venture Round in 2011
Bridgelux, Inc. is a developer and manufacturer of solid-state lighting technologies headquartered in Fremont, California. Founded in 2002, the company specializes in high-power, energy-efficient light-emitting diode (LED) solutions. Its product portfolio includes LED arrays, chips, subsystems, and surface mounts, catering to various applications such as retail, hospitality, healthcare, and outdoor lighting. Bridgelux aims to replace traditional lighting technologies, like incandescent and fluorescent lamps, with advanced solid-state products that offer enhanced performance and significant energy savings. The company also provides testing, application engineering, and reference design services to support its customers in implementing these technologies. With strategic partnerships with industry leaders, Bridgelux is committed to driving innovation and contributing to global clean energy initiatives.

Contour Energy

Series C in 2011
Contour Energy is a company of portable power that commercializes customizable battery technologies for a wide range of cross-industry applications. It designs its next-generation battery systems to deliver unprecedented improvements in energy and power density, and are capable of performing in extreme operating conditions at significantly improved costs. Founded through the collaboration of Caltech and CNRS, the French National Center for Scientific Research, It combines expertise in nano-materials science, patented fluorine-based battery chemistries and manufacturing processes to significantly advance the state of portable power. With its headquarters in Azusa in California, a team of battery industry leaders from Caltech, Energizer, General Electric, Hewlett-Packard, Sanyo and Valence Technologies manages it. Private entrepreneurs hold it.

Metabolon

Series D in 2011
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

HZO

Series B in 2011
HZO specializes in protective nano and conformal coatings designed to safeguard electronic components in challenging environments. Founded in 2011 and headquartered in Morrisville, North Carolina, the company offers innovative water protection solutions tailored for electronics manufacturers. By utilizing advanced thin-film protective technology, including Parylene coatings, HZO enables manufacturers to create durable products capable of withstanding corrosive and liquid exposure. Its focus on nanotechnology and waterproofing allows for effective protection of electronic circuits and components, ensuring reliability in wet and harsh conditions.

PWA

Series A in 2011
PWA specializes in advanced water treatment technologies, primarily focusing on its patented Osorb® media system. This innovative, regenerable media effectively removes free, dispersed, and soluble hydrocarbons, along with toxic contaminants from oilfield water and gas streams. The main application of Osorb® is in the treatment of produced water, ensuring compliance with discharge and reinjection standards. By addressing the critical need for safe and efficient water management in the oil and gas industry, PWA plays a significant role in enhancing environmental sustainability and resource recovery.

Kovio

Venture Round in 2011
Kovio Inc. is a privately held company based in Silicon Valley that specializes in the development of innovative semiconductor products utilizing printed silicon electronics and thin film technology. Founded at the MIT Media Laboratory, Kovio focuses on creating low-cost manufacturing solutions that leverage the advantages of graphics printing alongside the capabilities of silicon-based semiconductors. The company designs, develops, and manufactures printed silicon products for various applications, particularly in the Near Field Communication (NFC) and Electronic Article Surveillance (EAS) markets. Its product offerings include Radio Frequency Identification (RFID) tags and NFC barcodes, positioning Kovio as a key player in the advancement of printed electronics.

Cobalt Technologies

Series D in 2011
Cobalt Technologies is a biotechnology company founded in 2005 and headquartered in Mountain View, California. The company specializes in developing innovative technologies for the production of biofuels, particularly focusing on next-generation bio n-butanol. Cobalt's advancements enable the creation of low-cost, commercial-scale biobutanol, which serves as a sustainable alternative to petroleum-based products. This bio-based chemical can be utilized in a wide range of applications, including fuels, jet fuel, bio-based plastics, synthetic rubber, paints, adhesives, and solvents. By providing cost-effective substitutes to traditional petroleum-derived chemicals, Cobalt Technologies aims to contribute to cleaner burning fuels and a reduced environmental impact.

Nano Terra

Debt Financing in 2011
Nano Terra, Inc. is a surface engineering and nanotechnology co-development company based in Cambridge, Massachusetts. Established in 2005, it specializes in the development and commercialization of advanced materials, coatings, polymer formulations, and high-resolution printing technologies. The company focuses on creating innovative solutions, including ultra-thin electronic displays, fuel cells, sensors, and solar power devices. It serves a diverse range of industries, including aerospace, automotive, healthcare, and electronics, by leveraging its expertise in surface science and advanced materials to help clients bring transformative products to market. Nano Terra also addresses critical challenges in national defense and human health through its work in diagnostics and counterfeit detection.

SIONYX

Series B in 2010
SiOnyx, Inc. is a company based in Beverly, Massachusetts, that specializes in advanced semiconductor technology focusing on shallow junction photonics. Founded in 2005, SiOnyx enhances the infrared sensitivity of silicon-based photonics, leading to significant improvements in light-sensing devices. The company develops ultra-low-light image sensors and night vision camera systems that cater to a diverse range of applications, including security, defense, consumer electronics, industrial, medical, and automotive sectors. Its product offerings include XQE CMOS image sensors, which enable functionalities such as night vision, biometrics, and eye-tracking, as well as HD action video cameras. SiOnyx is recognized for making digital night vision technology more accessible, thereby enhancing optoelectronic response in both visible and near-infrared regions.

GEO Semiconductor

Debt Financing in 2010
GEO Semiconductor Inc. is a fabless semiconductor company specializing in the development and distribution of video processors for automotive and other applications. Founded in 2009 and headquartered in San Jose, California, with additional operations in Toronto, Orlando, and Bengaluru, the company offers advanced geometric processing, image signal processing, and video compression solutions. GEO's products, including system-on-chip processors and evaluation boards, are utilized in a variety of markets such as automotive cameras, security IP cameras, projectors, and consumer electronics. The company's technology enables high-definition imaging and video quality, supporting applications in home monitoring, automotive surveillance, and various display systems. GEO Semiconductor serves clients through representatives and distributors both domestically and internationally.

Laser Light Engines

Series B in 2010
Laser Light Engines, Inc. is a company that specializes in the design, development, and manufacturing of digitally controlled laser-driven light engines for illumination applications. Established in 2008 and headquartered in Salem, New Hampshire, the company has pioneered laser illumination technologies that enhance digital projection capabilities. By replacing traditional lamps, these technologies deliver significantly brighter colors and sharper images while reducing energy consumption and costs. Laser Light Engines aims to provide clients with superior projected images, marking a notable advancement in the field of illumination.

Adesto Technologies

Venture Round in 2010
Adesto Technologies is a prominent provider of application-specific semiconductors and embedded systems tailored for Internet of Things (IoT) applications. The company serves over 5,000 customers globally, offering a diverse range of technologies that support industrial, consumer, medical, and communications markets. Adesto's products are designed to enhance the performance and cost-effectiveness of connected IoT devices, which include smart utility meters, wearable fitness trackers, medical monitors, and home automation systems. The company's extensive portfolio features IoT edge servers, routers, network nodes, communication modules, and various memory technologies. In addition to hardware, Adesto provides software, development kits, and system solutions to facilitate faster market entry for its clients. By leveraging their expertise and proprietary intellectual property, Adesto enables customers to create innovative and reliable IoT solutions, ultimately leading to improved efficiency and lower operational costs.

Contour Energy

Series B in 2010
Contour Energy is a company of portable power that commercializes customizable battery technologies for a wide range of cross-industry applications. It designs its next-generation battery systems to deliver unprecedented improvements in energy and power density, and are capable of performing in extreme operating conditions at significantly improved costs. Founded through the collaboration of Caltech and CNRS, the French National Center for Scientific Research, It combines expertise in nano-materials science, patented fluorine-based battery chemistries and manufacturing processes to significantly advance the state of portable power. With its headquarters in Azusa in California, a team of battery industry leaders from Caltech, Energizer, General Electric, Hewlett-Packard, Sanyo and Valence Technologies manages it. Private entrepreneurs hold it.

BridgeLux

Series D in 2010
Bridgelux, Inc. is a developer and manufacturer of solid-state lighting technologies headquartered in Fremont, California. Founded in 2002, the company specializes in high-power, energy-efficient light-emitting diode (LED) solutions. Its product portfolio includes LED arrays, chips, subsystems, and surface mounts, catering to various applications such as retail, hospitality, healthcare, and outdoor lighting. Bridgelux aims to replace traditional lighting technologies, like incandescent and fluorescent lamps, with advanced solid-state products that offer enhanced performance and significant energy savings. The company also provides testing, application engineering, and reference design services to support its customers in implementing these technologies. With strategic partnerships with industry leaders, Bridgelux is committed to driving innovation and contributing to global clean energy initiatives.

Innovalight

Series D in 2010
Innovalight, founded by Conrad Burke, specializes in the development of high-efficiency, low-cost solar modules aimed at both residential and commercial applications. The company is notable for its innovative approach to solar technology, utilizing a proprietary silicon ink that has been in development since 2005. This liquid-based processing method significantly enhances the cost-effectiveness and efficiency of solar modules compared to traditional solid or gas processing techniques. Innovalight's focus on ultra thin-film power modules positions it as a key player in the solar energy sector, particularly in the realm of grid-connected solar power generation.

Metabolon

Series C in 2009
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

Laser Light Engines

Debt Financing in 2009
Laser Light Engines, Inc. is a company that specializes in the design, development, and manufacturing of digitally controlled laser-driven light engines for illumination applications. Established in 2008 and headquartered in Salem, New Hampshire, the company has pioneered laser illumination technologies that enhance digital projection capabilities. By replacing traditional lamps, these technologies deliver significantly brighter colors and sharper images while reducing energy consumption and costs. Laser Light Engines aims to provide clients with superior projected images, marking a notable advancement in the field of illumination.

Metabolon

Series C in 2009
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

Innovalight

Venture Round in 2009
Innovalight, founded by Conrad Burke, specializes in the development of high-efficiency, low-cost solar modules aimed at both residential and commercial applications. The company is notable for its innovative approach to solar technology, utilizing a proprietary silicon ink that has been in development since 2005. This liquid-based processing method significantly enhances the cost-effectiveness and efficiency of solar modules compared to traditional solid or gas processing techniques. Innovalight's focus on ultra thin-film power modules positions it as a key player in the solar energy sector, particularly in the realm of grid-connected solar power generation.

Solazyme

Series D in 2009
Solazyme is a synthetic biology company that specializes in converting algal biomass into biofuels. Solazyme not only creates biofuels for the the transportation industry, but is experimenting with ways to tailor its products for the cosmetic and food industries.

Contour Energy

Series A in 2008
Contour Energy is a company of portable power that commercializes customizable battery technologies for a wide range of cross-industry applications. It designs its next-generation battery systems to deliver unprecedented improvements in energy and power density, and are capable of performing in extreme operating conditions at significantly improved costs. Founded through the collaboration of Caltech and CNRS, the French National Center for Scientific Research, It combines expertise in nano-materials science, patented fluorine-based battery chemistries and manufacturing processes to significantly advance the state of portable power. With its headquarters in Azusa in California, a team of battery industry leaders from Caltech, Energizer, General Electric, Hewlett-Packard, Sanyo and Valence Technologies manages it. Private entrepreneurs hold it.

Tetravitae Biosciences

Series A in 2008
Tetravitae Biosciences specializes in the development of bio-based chemicals, plastics, and fuels, utilizing a proprietary technology that focuses on industrial fermentations and microbiological processes. The company produces bio-butanol from biomass substrates through microbial fermentation, which enables the creation of sustainable alternatives to petroleum-derived products. By leveraging its expertise in process engineering and microbiology, Tetravitae aims to significantly reduce production costs, enhancing competitiveness in the market for renewable materials.

Cobalt Technologies

Series C in 2008
Cobalt Technologies is a biotechnology company founded in 2005 and headquartered in Mountain View, California. The company specializes in developing innovative technologies for the production of biofuels, particularly focusing on next-generation bio n-butanol. Cobalt's advancements enable the creation of low-cost, commercial-scale biobutanol, which serves as a sustainable alternative to petroleum-based products. This bio-based chemical can be utilized in a wide range of applications, including fuels, jet fuel, bio-based plastics, synthetic rubber, paints, adhesives, and solvents. By providing cost-effective substitutes to traditional petroleum-derived chemicals, Cobalt Technologies aims to contribute to cleaner burning fuels and a reduced environmental impact.

Solazyme

Series C in 2008
Solazyme is a synthetic biology company that specializes in converting algal biomass into biofuels. Solazyme not only creates biofuels for the the transportation industry, but is experimenting with ways to tailor its products for the cosmetic and food industries.

Nextreme Thermal Solutions

Series B in 2008
Nextreme designs and manufactures micro-scale thermal and power management products for the semiconductor, photonics, consumer, automotive and defense/aerospace industries. The company has embedded cooling and power generation capabilities into the widely accepted copper pillar bumping process used in high-volume electronic packaging. Nextreme’s breakthrough addresses the most challenging thermal and power management constraints in electronics today, and delivers the only fully-scalable technology solution by leveraging the existing, high-volume flip chip manufacturing infrastructure. By minimizing the need for manufacturing changes and focusing on developing a seamless design-in solution, Nextreme is changing the future of thermal and power management for the entire electronics industry.

Laser Light Engines

Series A in 2008
Laser Light Engines, Inc. is a company that specializes in the design, development, and manufacturing of digitally controlled laser-driven light engines for illumination applications. Established in 2008 and headquartered in Salem, New Hampshire, the company has pioneered laser illumination technologies that enhance digital projection capabilities. By replacing traditional lamps, these technologies deliver significantly brighter colors and sharper images while reducing energy consumption and costs. Laser Light Engines aims to provide clients with superior projected images, marking a notable advancement in the field of illumination.

Adesto Technologies

Series A in 2008
Adesto Technologies is a prominent provider of application-specific semiconductors and embedded systems tailored for Internet of Things (IoT) applications. The company serves over 5,000 customers globally, offering a diverse range of technologies that support industrial, consumer, medical, and communications markets. Adesto's products are designed to enhance the performance and cost-effectiveness of connected IoT devices, which include smart utility meters, wearable fitness trackers, medical monitors, and home automation systems. The company's extensive portfolio features IoT edge servers, routers, network nodes, communication modules, and various memory technologies. In addition to hardware, Adesto provides software, development kits, and system solutions to facilitate faster market entry for its clients. By leveraging their expertise and proprietary intellectual property, Adesto enables customers to create innovative and reliable IoT solutions, ultimately leading to improved efficiency and lower operational costs.

BridgeLux

Series D in 2008
Bridgelux, Inc. is a developer and manufacturer of solid-state lighting technologies headquartered in Fremont, California. Founded in 2002, the company specializes in high-power, energy-efficient light-emitting diode (LED) solutions. Its product portfolio includes LED arrays, chips, subsystems, and surface mounts, catering to various applications such as retail, hospitality, healthcare, and outdoor lighting. Bridgelux aims to replace traditional lighting technologies, like incandescent and fluorescent lamps, with advanced solid-state products that offer enhanced performance and significant energy savings. The company also provides testing, application engineering, and reference design services to support its customers in implementing these technologies. With strategic partnerships with industry leaders, Bridgelux is committed to driving innovation and contributing to global clean energy initiatives.

Metabolon

Series C in 2008
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

PolyRemedy

Series B in 2008
PolyRemedy offers integrated wound management systems designed to increase consistency by extending wound care expertise to the point of care. The PolyRemedy Personalized Woundcare System (PWS) enables clinicians to document care through easy-to-use, web-based assessment tools and order personalized wound dressings, while also providing critical and unprecedented visibility into wound care data. It was founded in 2004 and is headquartered in Concord, Massachusetts.

D-Wave Systems

Series C in 2008
D-Wave Systems Inc. is a pioneering company in the field of quantum computing, recognized as the world’s first commercial supplier of quantum computers. Founded in 1999 and headquartered in Burnaby, Canada, D-Wave specializes in the development, fabrication, and integration of superconducting quantum computers. The company offers a range of products, including the D-Wave Two System, a commercial quantum computer, and D-Wave Hybrid, an open-source platform for creating hybrid quantum-classical applications. Leap, its cloud-based service, provides real-time access to quantum computing resources along with development tools and educational content. D-Wave’s quantum computers are applied across various sectors, addressing challenges in mission planning, logistics, machine learning, and optimization problems, among others. The company serves diverse industries, including defense, finance, energy, and academia, and also offers professional services, training, and customer support to enhance user experience and application development.

Ensemble Discovery

Series B in 2007
Ensemble Discovery is developing a new class of therapeutics - the Ensemblinsâ„¢, orally bioavailable small molecule macrocyclic compounds that have the potential to behave like biologics and can disrupt protein-protein interactions. They have two complementary platforms that provide access to these molecules. Firstly, they use their proprietary DNA-Programmed Chemistryâ„¢ (DPCâ„¢) platform to generate hundreds of thousands of these molecules for rapid screening. Secondly, they have highly developed methods for the synthesis of Ensemblins as discrete molecules using conventional chemistry.

Innovalight

Series C in 2007
Innovalight, founded by Conrad Burke, specializes in the development of high-efficiency, low-cost solar modules aimed at both residential and commercial applications. The company is notable for its innovative approach to solar technology, utilizing a proprietary silicon ink that has been in development since 2005. This liquid-based processing method significantly enhances the cost-effectiveness and efficiency of solar modules compared to traditional solid or gas processing techniques. Innovalight's focus on ultra thin-film power modules positions it as a key player in the solar energy sector, particularly in the realm of grid-connected solar power generation.

SIONYX

Series A in 2007
SiOnyx, Inc. is a company based in Beverly, Massachusetts, that specializes in advanced semiconductor technology focusing on shallow junction photonics. Founded in 2005, SiOnyx enhances the infrared sensitivity of silicon-based photonics, leading to significant improvements in light-sensing devices. The company develops ultra-low-light image sensors and night vision camera systems that cater to a diverse range of applications, including security, defense, consumer electronics, industrial, medical, and automotive sectors. Its product offerings include XQE CMOS image sensors, which enable functionalities such as night vision, biometrics, and eye-tracking, as well as HD action video cameras. SiOnyx is recognized for making digital night vision technology more accessible, thereby enhancing optoelectronic response in both visible and near-infrared regions.

Chlorogen

Venture Round in 2007
Chlorogen a biopharmaceutical company, engages in the development and manufacture of proteins for human therapy. The company, through its chloroplast transformation technology (CTT), offers plant made drugs for the treatment and prevention of human diseases, as well as for treatment of women's reproductive cancers. Its products include therapeutic proteins in tobacco that are made using chloroplast transformation technology. The chloroplast transformation technology facilitates hyper-expression of recombinant proteins in tobacco chloroplasts. The company offers its chloroplast-tobacco platform for commercial use in food and agriculture. Chlorogen, Inc. was founded in 2002 and is based in St. Louis, Missouri.

Kovio

Series D in 2007
Kovio Inc. is a privately held company based in Silicon Valley that specializes in the development of innovative semiconductor products utilizing printed silicon electronics and thin film technology. Founded at the MIT Media Laboratory, Kovio focuses on creating low-cost manufacturing solutions that leverage the advantages of graphics printing alongside the capabilities of silicon-based semiconductors. The company designs, develops, and manufactures printed silicon products for various applications, particularly in the Near Field Communication (NFC) and Electronic Article Surveillance (EAS) markets. Its product offerings include Radio Frequency Identification (RFID) tags and NFC barcodes, positioning Kovio as a key player in the advancement of printed electronics.

BridgeLux

Series C in 2007
Bridgelux, Inc. is a developer and manufacturer of solid-state lighting technologies headquartered in Fremont, California. Founded in 2002, the company specializes in high-power, energy-efficient light-emitting diode (LED) solutions. Its product portfolio includes LED arrays, chips, subsystems, and surface mounts, catering to various applications such as retail, hospitality, healthcare, and outdoor lighting. Bridgelux aims to replace traditional lighting technologies, like incandescent and fluorescent lamps, with advanced solid-state products that offer enhanced performance and significant energy savings. The company also provides testing, application engineering, and reference design services to support its customers in implementing these technologies. With strategic partnerships with industry leaders, Bridgelux is committed to driving innovation and contributing to global clean energy initiatives.

Xradia

Series D in 2007
Xradia develops technology to help advance innovation in science and industry by providing unique insight through superior X-ray imaging solutions. Our products utilize advanced X-ray computed tomography (CT) imaging methodology and optics to nondestructively produce 3D images of objects with exceptional spatial resolution and contrast. Xradia's technology is based on proprietary X-ray optics and detectors. Xradia produces state-of-the-art far-field ambient environment imaging systems capable of 3D imaging with resolution below 50 nm. Xradia's commercial products have 3D resolution from the nanometer level up to several hundred microns.

Crystal IS

Series B in 2006
Crystal IS is a leading manufacturer specializing in the commercialization of single-crystal aluminum nitride (AlN) substrates and ultraviolet light emitting diodes (UV LEDs) based on this technology. The company's products are designed for cost-effective and energy-efficient water and air purification applications. Crystal IS offers high-performance UVC LEDs that are suitable for a range of uses, including disinfection in consumer and commercial appliances, medical devices, and life sciences. By providing advanced solutions in water and air purification, Crystal IS enables its clients to enhance the quality and effectiveness of their products across various industries.

SIONYX

Series A in 2006
SiOnyx, Inc. is a company based in Beverly, Massachusetts, that specializes in advanced semiconductor technology focusing on shallow junction photonics. Founded in 2005, SiOnyx enhances the infrared sensitivity of silicon-based photonics, leading to significant improvements in light-sensing devices. The company develops ultra-low-light image sensors and night vision camera systems that cater to a diverse range of applications, including security, defense, consumer electronics, industrial, medical, and automotive sectors. Its product offerings include XQE CMOS image sensors, which enable functionalities such as night vision, biometrics, and eye-tracking, as well as HD action video cameras. SiOnyx is recognized for making digital night vision technology more accessible, thereby enhancing optoelectronic response in both visible and near-infrared regions.

NanoOpto

Series D in 2006
NanoOpto is a manufacturer specializing in integrated modular nano-optic components for optical systems and networks. The company utilizes proprietary nano-optics and nano-manufacturing technology to develop a range of products, including infrared cut filters, nano-optic isolators, deep ultraviolet polarizers, polarizing beam splitters, optical isolators, microlens arrays, and waveplates. Based on extensive research, NanoOpto's innovations enable rapid prototyping and enhance performance while reducing overall system costs. In addition to its product offerings, the company provides services such as conformal optical coatings through atomic layer deposition, precision coatings via e-beam deposition, precision dicing, and optical design and engineering. NanoOpto operates a high-volume manufacturing facility in Somerset, New Jersey, where it employs subwavelength techniques to improve conventional optical components and develop new classes of integrated components.

NeoPhotonics

Series C in 2006
NeoPhotonics is a technology company specializing in the development, manufacture, and sale of optical components and subsystems used in high-speed digital communications networks. The company offers a comprehensive range of active and passive optical products tailored for various market segments, including fiber-to-the-home (FTTH), data communications, storage area networks, and both metro and long-haul networks. Its product lineup includes transceivers, integrated splitters, multiplexers, and advanced optical modules, all designed to support a wide array of data rates and applications. Notably, NeoPhotonics is recognized for its innovative silica Planar Lightwave Circuit (PLC) technology, which plays a crucial role in modern optical networks. Additionally, the company produces MEMS-based Variable Optical Attenuators and Dynamic Channel Equalizers, enhancing the performance and efficiency of communication systems.

Cswitch

Series B in 2006
Cswitch specializes in developing system-on-a-chip semiconductors tailored for networking-based platforms. Founded by a team of experienced semiconductor executives, the company leverages their extensive background in advanced processors and ASIC development to create innovative configurable solutions. In addition to semiconductors, Cswitch provides design tools for configurable switch array devices and offers development and validation boards that facilitate the design and verification of various networking applications. Their focus spans multiple markets, including networking, telecommunications, storage, and wireless base stations, enabling them to address a wide range of industry needs.

D-Wave Systems

Series B in 2006
D-Wave Systems Inc. is a pioneering company in the field of quantum computing, recognized as the world’s first commercial supplier of quantum computers. Founded in 1999 and headquartered in Burnaby, Canada, D-Wave specializes in the development, fabrication, and integration of superconducting quantum computers. The company offers a range of products, including the D-Wave Two System, a commercial quantum computer, and D-Wave Hybrid, an open-source platform for creating hybrid quantum-classical applications. Leap, its cloud-based service, provides real-time access to quantum computing resources along with development tools and educational content. D-Wave’s quantum computers are applied across various sectors, addressing challenges in mission planning, logistics, machine learning, and optimization problems, among others. The company serves diverse industries, including defense, finance, energy, and academia, and also offers professional services, training, and customer support to enhance user experience and application development.

Innovalight

Series B in 2006
Innovalight, founded by Conrad Burke, specializes in the development of high-efficiency, low-cost solar modules aimed at both residential and commercial applications. The company is notable for its innovative approach to solar technology, utilizing a proprietary silicon ink that has been in development since 2005. This liquid-based processing method significantly enhances the cost-effectiveness and efficiency of solar modules compared to traditional solid or gas processing techniques. Innovalight's focus on ultra thin-film power modules positions it as a key player in the solar energy sector, particularly in the realm of grid-connected solar power generation.

Cswitch

Series B in 2006
Cswitch specializes in developing system-on-a-chip semiconductors tailored for networking-based platforms. Founded by a team of experienced semiconductor executives, the company leverages their extensive background in advanced processors and ASIC development to create innovative configurable solutions. In addition to semiconductors, Cswitch provides design tools for configurable switch array devices and offers development and validation boards that facilitate the design and verification of various networking applications. Their focus spans multiple markets, including networking, telecommunications, storage, and wireless base stations, enabling them to address a wide range of industry needs.

BridgeLux

Venture Round in 2006
Bridgelux, Inc. is a developer and manufacturer of solid-state lighting technologies headquartered in Fremont, California. Founded in 2002, the company specializes in high-power, energy-efficient light-emitting diode (LED) solutions. Its product portfolio includes LED arrays, chips, subsystems, and surface mounts, catering to various applications such as retail, hospitality, healthcare, and outdoor lighting. Bridgelux aims to replace traditional lighting technologies, like incandescent and fluorescent lamps, with advanced solid-state products that offer enhanced performance and significant energy savings. The company also provides testing, application engineering, and reference design services to support its customers in implementing these technologies. With strategic partnerships with industry leaders, Bridgelux is committed to driving innovation and contributing to global clean energy initiatives.

NanoGram

Venture Round in 2006
NanoGram Corporation is a nanotechnology company that develops and manufactures products for advanced applications in photovoltaics, electronics, and displays. It offers a customized application-specific nanotechnology platform that provides tailored nanoscale compositions for various industries, including optical, electronic, imaging, biomedical, and energy sectors. The company has successfully incubated and spun out two notable entities, NeoPhotonics and NanoGram Devices. With offices in Tokyo and Seoul, NanoGram enhances its presence in Asia through strategic partnerships, including a collaboration with Nagase & Co., Ltd/Nagase ChemteX Corporation, facilitating development and manufacturing supply relationships in Japan and addressing expanding market opportunities in Korea.

Metabolon

Series B in 2006
Metabolon, Inc. is a health technology company specializing in metabolomics, focusing on the development of diagnostic tests and analytical methods for early disease detection and precision medicine. The company offers a range of clinical diagnostics, including QUANTOSE IR for measuring insulin resistance, QUANTOSE IGT for assessing glucose tolerance, and Meta IMD for identifying metabolites linked to inherited metabolic disorders. In addition to its diagnostic capabilities, Metabolon provides customizable research services and multiomics solutions to support academic and commercial investigations across various life science sectors. Its technologies are applicable in areas such as cardiovascular health, diabetes, oncology, and respiratory disorders. Founded in 2000 and headquartered in Morrisville, North Carolina, with additional offices in Europe and sales locations in the UK, Spain, and China, Metabolon collaborates with numerous strategic partners in the pharmaceutical and biotechnology industries to enhance research and development outcomes.

Kovio

Venture Round in 2005
Kovio Inc. is a privately held company based in Silicon Valley that specializes in the development of innovative semiconductor products utilizing printed silicon electronics and thin film technology. Founded at the MIT Media Laboratory, Kovio focuses on creating low-cost manufacturing solutions that leverage the advantages of graphics printing alongside the capabilities of silicon-based semiconductors. The company designs, develops, and manufactures printed silicon products for various applications, particularly in the Near Field Communication (NFC) and Electronic Article Surveillance (EAS) markets. Its product offerings include Radio Frequency Identification (RFID) tags and NFC barcodes, positioning Kovio as a key player in the advancement of printed electronics.

Mersana Therapeutics

Venture Round in 2005
Mersana Therapeutics is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, focused on developing innovative antibody-drug conjugates (ADCs) for cancer patients with unmet medical needs. The company utilizes its proprietary Dolaflexin platform to create a pipeline of novel ADC candidates designed to improve treatment outcomes for those not responding to traditional therapies. Mersana's lead product candidate, XMT-1536, targets NaPi2b and is currently undergoing Phase I clinical trials for ovarian cancer, non-small cell lung cancer, and other orphan indications. In addition to XMT-1536, the company is advancing several early-stage programs, including XMT-1660, which targets B7-H4, and XMT-2056, a STING agonist ADC. Mersana has established strategic partnerships for research and development, notably with Merck KGaA and Asana BioSciences, to enhance its ADC product portfolio. Founded in 2005, Mersana Therapeutics continues to innovate in the field of oncology therapeutics.

Molecular Imprints

Series C in 2005
Molecular Imprints Inc. is a company based in Austin, Texas, that specializes in the manufacture of imprint and lithography systems designed for creating nanometer-scale surface relief structures. Founded in 2001 as a spin-off from the University of Texas, the company has developed a robust portfolio of over 100 patents related to imprint tools, materials, and process technologies. Its core technology, Jet and Flash Imprint Lithography, utilizes an advanced Drop Pattern Generation System to enable precise deposition of photoresist on substrates in extremely small quantities, facilitating the consistent nanoimprinting of features down to 10 nanometers. This innovative approach caters to various high-tech industries, including displays, life sciences, and light-emitting diodes, by providing cost-effective solutions for nanopatterning applications.

Chlorogen

Series B in 2005
Chlorogen a biopharmaceutical company, engages in the development and manufacture of proteins for human therapy. The company, through its chloroplast transformation technology (CTT), offers plant made drugs for the treatment and prevention of human diseases, as well as for treatment of women's reproductive cancers. Its products include therapeutic proteins in tobacco that are made using chloroplast transformation technology. The chloroplast transformation technology facilitates hyper-expression of recombinant proteins in tobacco chloroplasts. The company offers its chloroplast-tobacco platform for commercial use in food and agriculture. Chlorogen, Inc. was founded in 2002 and is based in St. Louis, Missouri.

NeoPhotonics

Venture Round in 2005
NeoPhotonics is a technology company specializing in the development, manufacture, and sale of optical components and subsystems used in high-speed digital communications networks. The company offers a comprehensive range of active and passive optical products tailored for various market segments, including fiber-to-the-home (FTTH), data communications, storage area networks, and both metro and long-haul networks. Its product lineup includes transceivers, integrated splitters, multiplexers, and advanced optical modules, all designed to support a wide array of data rates and applications. Notably, NeoPhotonics is recognized for its innovative silica Planar Lightwave Circuit (PLC) technology, which plays a crucial role in modern optical networks. Additionally, the company produces MEMS-based Variable Optical Attenuators and Dynamic Channel Equalizers, enhancing the performance and efficiency of communication systems.

NanoOpto

Series C in 2005
NanoOpto is a manufacturer specializing in integrated modular nano-optic components for optical systems and networks. The company utilizes proprietary nano-optics and nano-manufacturing technology to develop a range of products, including infrared cut filters, nano-optic isolators, deep ultraviolet polarizers, polarizing beam splitters, optical isolators, microlens arrays, and waveplates. Based on extensive research, NanoOpto's innovations enable rapid prototyping and enhance performance while reducing overall system costs. In addition to its product offerings, the company provides services such as conformal optical coatings through atomic layer deposition, precision coatings via e-beam deposition, precision dicing, and optical design and engineering. NanoOpto operates a high-volume manufacturing facility in Somerset, New Jersey, where it employs subwavelength techniques to improve conventional optical components and develop new classes of integrated components.

Nanomix

Series C in 2005
Nanomix, Inc. is a biotechnology company that specializes in developing automated point-of-care diagnostic systems. Founded in 2000 and based in Emeryville, California, the company offers innovative products such as the Nanōmix eLab System, which integrates a handheld reader with a proprietary biosensor and assay cartridge. This system enables rapid diagnostic testing, providing actionable results in 10 minutes or less, crucial for timely medical decisions, especially in critical situations like sepsis detection. The eLab platform allows for multiple in-vitro diagnostic and enzymatic assays to be conducted simultaneously from a single whole-blood sample. Nanomix's focus on mobile diagnostics aims to enhance patient care and streamline healthcare processes by delivering superior performance in various settings, ultimately contributing to improved patient outcomes and reduced healthcare costs.

Nextreme Thermal Solutions

Series A in 2005
Nextreme designs and manufactures micro-scale thermal and power management products for the semiconductor, photonics, consumer, automotive and defense/aerospace industries. The company has embedded cooling and power generation capabilities into the widely accepted copper pillar bumping process used in high-volume electronic packaging. Nextreme’s breakthrough addresses the most challenging thermal and power management constraints in electronics today, and delivers the only fully-scalable technology solution by leveraging the existing, high-volume flip chip manufacturing infrastructure. By minimizing the need for manufacturing changes and focusing on developing a seamless design-in solution, Nextreme is changing the future of thermal and power management for the entire electronics industry.

Nantero

Series C in 2005
Nantero, Inc. is a nanotechnology company based in Woburn, Massachusetts, that specializes in the development of semiconductor products using carbon nanotubes. Founded in 2001, Nantero focuses on creating high-density, high-speed nonvolatile random access memory (NRAM) chips, which are designed for a range of applications including smartphones, tablets, enterprise systems, and automotive and industrial uses. The company's innovative memory technology offers advantages such as ultra-high density and zero power consumption in standby mode, making it a competitive alternative to traditional flash memory. In addition to NRAM, Nantero produces various semiconductor products, including nanoelectromechanical switches and memory and logic semiconductor products, while collaborating with licensees to explore additional applications of its core nanotube-based technology.

Cambrios Technologies

Series B in 2005
Cambrios Technologies Corporation is a manufacturer of innovative electronic materials specializing in silver nanowire-based electrodes. Founded in 2002 and originally named Semzyme, Inc., the company rebranded in August 2004. Headquartered in Sunnyvale, California, with additional offices in Japan and Taiwan, Cambrios develops products such as ClearOhm, which are transparent conductive coatings that can be applied to various substrates for multiple applications. These include touch screens, liquid crystal displays, e-paper, OLED devices, and lighting, as well as thin film photovoltaics like organic photovoltaics and printed organic solar cells. Cambrios's technology enables simplified manufacturing processes and enhances the performance of next-generation consumer devices.

Solazyme

Seed Round in 2004
Solazyme is a synthetic biology company that specializes in converting algal biomass into biofuels. Solazyme not only creates biofuels for the the transportation industry, but is experimenting with ways to tailor its products for the cosmetic and food industries.

NanoGram

Series B in 2004
NanoGram Corporation is a nanotechnology company that develops and manufactures products for advanced applications in photovoltaics, electronics, and displays. It offers a customized application-specific nanotechnology platform that provides tailored nanoscale compositions for various industries, including optical, electronic, imaging, biomedical, and energy sectors. The company has successfully incubated and spun out two notable entities, NeoPhotonics and NanoGram Devices. With offices in Tokyo and Seoul, NanoGram enhances its presence in Asia through strategic partnerships, including a collaboration with Nagase & Co., Ltd/Nagase ChemteX Corporation, facilitating development and manufacturing supply relationships in Japan and addressing expanding market opportunities in Korea.

Cswitch

Series A in 2004
Cswitch specializes in developing system-on-a-chip semiconductors tailored for networking-based platforms. Founded by a team of experienced semiconductor executives, the company leverages their extensive background in advanced processors and ASIC development to create innovative configurable solutions. In addition to semiconductors, Cswitch provides design tools for configurable switch array devices and offers development and validation boards that facilitate the design and verification of various networking applications. Their focus spans multiple markets, including networking, telecommunications, storage, and wireless base stations, enabling them to address a wide range of industry needs.

Nanotechnologies

Venture Round in 2004
NovaCentrix is a leader in manufacturing tools that enable printed electronics technologies. State-of-the-artPulseForge® tools utilize photonic curing which is a cutting edge technology that dries, sinters, and anneals functional inks in milliseconds on low-temperature, flexible substrates such as paper and plastic. NovaCentrixis seeking collaborative partners and customers for our patented photonic curing tools. These tools process a wide array of depositions including but not limited to metallic, non-metallic and semiconductor-based inks, as well as PVD metals and metal oxides. An integrated material and tool simulation package, SimPulse™, enables rapid assessment of the photonic curing capabilities in combination to experimental results. NovaCentrix also offers high-performance and economical Metalon® and PChemconductive inks, including the innovative and award-winning ICI copper-oxide reduction inks which work optimally with PulseForge tools given the need for high temperature processing of inks on low temperature substrates. NovaCentrix possesses in-house inkjet, screen, and flexographic presses and provides customers with prototyping services.

Molecular Imprints

Series B in 2004
Molecular Imprints Inc. is a company based in Austin, Texas, that specializes in the manufacture of imprint and lithography systems designed for creating nanometer-scale surface relief structures. Founded in 2001 as a spin-off from the University of Texas, the company has developed a robust portfolio of over 100 patents related to imprint tools, materials, and process technologies. Its core technology, Jet and Flash Imprint Lithography, utilizes an advanced Drop Pattern Generation System to enable precise deposition of photoresist on substrates in extremely small quantities, facilitating the consistent nanoimprinting of features down to 10 nanometers. This innovative approach caters to various high-tech industries, including displays, life sciences, and light-emitting diodes, by providing cost-effective solutions for nanopatterning applications.

Continuum Photonics

Series C in 2004
Continuum Photonics specializes in the development of optical layer connectivity products designed for managing and switching fiber-based optical networks. The company focuses on providing manufacturers of optical networking equipment with innovative subsystems that facilitate higher bandwidth capabilities and revenue-generating services at reduced costs. Among its key offerings are single-mode and multi-mode optical matrix switches, carrier optical monitor switches, and latching switches. Continuum Photonics is currently advancing a novel photonic switch aimed at addressing various challenges related to the delivery and management of optically-transported bandwidth, highlighting its commitment to enhancing operational efficiency and economic viability in the optical networking industry.

NeoPhotonics

Series B in 2004
NeoPhotonics is a technology company specializing in the development, manufacture, and sale of optical components and subsystems used in high-speed digital communications networks. The company offers a comprehensive range of active and passive optical products tailored for various market segments, including fiber-to-the-home (FTTH), data communications, storage area networks, and both metro and long-haul networks. Its product lineup includes transceivers, integrated splitters, multiplexers, and advanced optical modules, all designed to support a wide array of data rates and applications. Notably, NeoPhotonics is recognized for its innovative silica Planar Lightwave Circuit (PLC) technology, which plays a crucial role in modern optical networks. Additionally, the company produces MEMS-based Variable Optical Attenuators and Dynamic Channel Equalizers, enhancing the performance and efficiency of communication systems.

NanoOpto

Series B in 2003
NanoOpto is a manufacturer specializing in integrated modular nano-optic components for optical systems and networks. The company utilizes proprietary nano-optics and nano-manufacturing technology to develop a range of products, including infrared cut filters, nano-optic isolators, deep ultraviolet polarizers, polarizing beam splitters, optical isolators, microlens arrays, and waveplates. Based on extensive research, NanoOpto's innovations enable rapid prototyping and enhance performance while reducing overall system costs. In addition to its product offerings, the company provides services such as conformal optical coatings through atomic layer deposition, precision coatings via e-beam deposition, precision dicing, and optical design and engineering. NanoOpto operates a high-volume manufacturing facility in Somerset, New Jersey, where it employs subwavelength techniques to improve conventional optical components and develop new classes of integrated components.

Nantero

Series B in 2003
Nantero, Inc. is a nanotechnology company based in Woburn, Massachusetts, that specializes in the development of semiconductor products using carbon nanotubes. Founded in 2001, Nantero focuses on creating high-density, high-speed nonvolatile random access memory (NRAM) chips, which are designed for a range of applications including smartphones, tablets, enterprise systems, and automotive and industrial uses. The company's innovative memory technology offers advantages such as ultra-high density and zero power consumption in standby mode, making it a competitive alternative to traditional flash memory. In addition to NRAM, Nantero produces various semiconductor products, including nanoelectromechanical switches and memory and logic semiconductor products, while collaborating with licensees to explore additional applications of its core nanotube-based technology.

Nanogram Devices

Venture Round in 2003
Nanogram Devices, established in 2002 and headquartered in Milpitas, California, is a nanotechnology company specializing in the development of products that utilize nanomaterials for power sources in medical devices. The company focuses on advancing technology to enhance the functionality and efficiency of medical equipment through innovative power solutions.

Optiva

Series C in 2003
Optiva develops and manufactures nanomaterials for use in optical, electro-optical, and semiconductor applications.

Terion

Venture Round in 2002
Terion is a pioneering company in the un-tethered trailer tracking market, specializing in two-way wireless communication solutions for mobile applications within the transportation sector. With a focus on innovative technology, Terion has developed a comprehensive tracking and monitoring system that operates over 100,000 units on over-the-road trailers across the United States and Europe. The company's solutions enhance visibility and operational efficiency for fleet operators, making it a key player in the logistics and transportation industry.

Continuum Photonics

Series B in 2002
Continuum Photonics specializes in the development of optical layer connectivity products designed for managing and switching fiber-based optical networks. The company focuses on providing manufacturers of optical networking equipment with innovative subsystems that facilitate higher bandwidth capabilities and revenue-generating services at reduced costs. Among its key offerings are single-mode and multi-mode optical matrix switches, carrier optical monitor switches, and latching switches. Continuum Photonics is currently advancing a novel photonic switch aimed at addressing various challenges related to the delivery and management of optically-transported bandwidth, highlighting its commitment to enhancing operational efficiency and economic viability in the optical networking industry.

Nantero

Series A in 2001
Nantero, Inc. is a nanotechnology company based in Woburn, Massachusetts, that specializes in the development of semiconductor products using carbon nanotubes. Founded in 2001, Nantero focuses on creating high-density, high-speed nonvolatile random access memory (NRAM) chips, which are designed for a range of applications including smartphones, tablets, enterprise systems, and automotive and industrial uses. The company's innovative memory technology offers advantages such as ultra-high density and zero power consumption in standby mode, making it a competitive alternative to traditional flash memory. In addition to NRAM, Nantero produces various semiconductor products, including nanoelectromechanical switches and memory and logic semiconductor products, while collaborating with licensees to explore additional applications of its core nanotube-based technology.

Informio

Series A in 2000
Informio,Inc trial service delivers Internet content and voice applications through any wireless phone. It has been developed by people who pioneered voice messaging systems and the World Wide Web. Find out about what they're doing by subscribing to their mailing list.

Solesence

Series D in 1994
Nanophase Technologies Corporation, founded in 1989 and headquartered in Romeoville, Illinois, specializes in the production of engineered nanomaterials for diverse industrial applications. The company focuses on developing nano-engineered solutions, offering surface-engineered zinc oxide and titanium dioxide for sunscreens and personal care products. It also provides fully formulated cosmetics under the Solésence brand. Additionally, Nanophase produces advanced materials, including architectural and industrial coatings, abrasion-resistant additives, plastics additives, and products for medical diagnostics. Its technologies aim to deliver tailored nanomaterial solutions across various markets, including personal care, energy, and surface finishing applications. Through its integrated approach, Nanophase Technologies plays a significant role in enhancing product performance across multiple sectors.
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