CRG

Zing Health is a tech-enabled insurance company focused on providing Medicare Advantage plans tailored for individuals aged 65 and over. With a community-based approach, Zing Health emphasizes the significance of social determinants of health in promoting wellness among its members. The company aims to place both physicians and members at the forefront of the healthcare experience, facilitating a more personalized and supportive environment. Zing Health offers individualized assistance to ensure a smooth transition for new members, along with the opportunity to customize their healthcare plans. Additionally, members have access to facilities designed to address their specific healthcare needs and benefit from a dedicated care team that supports their health management. By targeting historically underserved populations, Zing Health strives to reduce healthcare disparities and enhance the overall health outcomes of its members.

T2 Biosystems, Inc. is an in vitro diagnostics company specializing in the rapid detection of pathogens and biomarkers to enhance patient care. The company employs its proprietary T2 Magnetic Resonance technology, which allows for the detection of various pathogens directly from unpurified patient samples, such as whole blood and urine, without the need for extensive sample preparation. T2 Biosystems offers several diagnostic products, including the T2Dx Instrument, which is designed to identify pathogens associated with sepsis and Lyme disease. Its product lineup includes the T2Candida Panel for detecting Candida species, the T2Bacteria Panel for identifying bacterial pathogens, the T2SARS-CoV-2 Panel for COVID-19 testing, and the T2Resistance Panel for detecting antibiotic resistance markers. Founded in 2006 and headquartered in Lexington, Massachusetts, T2 Biosystems aims to improve clinical outcomes and reduce healthcare costs by enabling faster and more accurate diagnostic testing.

Calyxo is a medical device company established in 2016, dedicated to enhancing care for patients with kidney stones. The company specializes in developing innovative solutions to address this common and painful condition, which places significant demands on healthcare resources. Led by experienced executives and investors with a proven track record in urology, Calyxo's team is committed to making a difference in kidney stone treatment. Their flagship product is a vacuum-assisted retrieval device designed to efficiently remove multiple kidney stone fragments in a single insertion, providing an effective and intuitive procedure for doctors.

NavaDerm Partners, LLC is a healthcare management company specializing in dermatology services, encompassing medical, surgical, and cosmetic procedures. Founded in 2018, it operates several centers in New York and New Jersey, providing a range of treatments including acne management, skin cancer care, and cosmetic enhancements such as laser treatments and body contouring. NavaDerm Partners supports a network of over 40 board-certified dermatologists and their teams, facilitating high-quality patient care across its eight locations. The company also offers practice management services, including accounting, human resources, and IT support, allowing clinicians to concentrate on delivering exceptional medical care while enhancing their practice's reputation and patient referrals.

Treace Medical Concepts, Inc. is a medical device company based in Ponte Vedra Beach, Florida, specializing in the design, manufacture, and marketing of innovative devices and biologic solutions for foot and ankle physicians. Founded in 2014, the company focuses on advancing the standard of care in the surgical management of bunion deformities, highlighted by its patented Lapiplasty 3D Bunion Correction procedure. This procedure aims to effectively correct all planes of bunion deformities while addressing their root causes, enabling patients to resume active lifestyles swiftly. Additionally, Treace Medical Concepts offers the ProHarvester, a percutaneous autograft extraction system that allows surgeons to harvest autograft bone and bone marrow through a minimally-invasive approach. By providing these advanced technologies, the company seeks to enhance patient outcomes and reduce healthcare costs in the growing $1.1 billion U.S. market for foot and ankle surgical products.

Aerin Medical Inc. is a health technology company based in Sunnyvale, California, specializing in non-invasive treatment solutions for nasal breathing disorders. Founded in 2011, the company develops therapeutic devices that utilize low-power radiofrequency energy to remodel nasal soft tissues, addressing underlying causes of conditions like nasal obstruction and chronic rhinitis. Its flagship products include the VivAer procedure and device for nasal airway obstruction, as well as the RhinAer procedure and device for chronic rhinitis. These innovative offerings enable ENT physicians to provide effective treatments in an office setting, often with local anesthesia and little to no downtime for patients, making them appealing alternatives to traditional invasive surgeries.

Harmony Biosciences, established in 2017 and based in Plymouth Meeting, Pennsylvania, is a biopharmaceutical company focused on developing and commercializing therapies for patients with rare neurological disorders. Its primary product, WAKIX (pitolisant), is a first-in-class medication designed to increase histamine signaling in the brain, approved for treating cataplexy in adult narcolepsy patients. Harmony Biosciences operates as a subsidiary of Harmony Biosciences Holdings, Inc., which is dedicated to addressing unmet medical needs in this therapeutic area.

EyePoint Pharmaceuticals, Inc. is a specialty biopharmaceutical company focused on developing and commercializing ophthalmic products for the treatment of eye diseases in the United States and Europe. The company offers several FDA-approved products, including ILUVIEN for diabetic macular edema, YUTIQ for chronic non-infectious uveitis, DEXYCU for post-operative ocular inflammation, and Retisert for posterior segment uveitis. Additionally, EyePoint is advancing its pipeline with innovative therapies such as EYP-1901, targeting wet age-related macular degeneration and diabetic retinopathy, and YUTIQ50 for uveitis. The company employs its proprietary Durasert and Verisome technology platforms to create sustained-release drug delivery systems that provide controlled drug delivery over extended periods. EyePoint has established strategic collaborations with various organizations to enhance its product offerings and has a commercial alliance for the joint promotion of DEXYCU. Founded in 1987 and headquartered in Watertown, Massachusetts, EyePoint was formerly known as pSivida Corp. and rebranded in March 2018.

Mid-Atlantic Dental Partners is a regional dental support organization (DSO) dedicated to enhancing the delivery of dental care through a collaborative approach involving patients, dentists, and support services. The organization provides a range of non-clinical services, including billing, collections, scheduling, practice marketing, financial management, clinical training, and dental staff recruitment. By managing these essential activities, Mid-Atlantic Dental Partners allows dental professionals to concentrate on patient care while maintaining clinical autonomy. The company is committed to improving the operational efficiency of dental practices and enhancing the work-life balance of its dental partners and their staff.

HNI Healthcare, previously known as Hospitalists Now, is a physician practice management company that leverages technology to enhance the delivery of facility-based physician services. The organization specializes in implementing full-service programs aimed at improving patient care quality through a clinically integrated care model. By focusing on value-based patient care, HNI Healthcare's platform assists hospitals and physicians in optimizing key quality and performance metrics, thereby promoting better health outcomes within healthcare facilities.

EndoGastric Solutions, Inc. is a medical device company focused on developing and commercializing innovative surgical technologies for the treatment of gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). The company offers products such as EsophyX, which enables transoral reconstructive surgery, and the EsophyX Z device used in the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions provides SerosaFuse Fasteners, a non-resorbable polypropylene material with strength comparable to traditional sutures. Beyond its product offerings, the company supports healthcare professionals through trainer-led courses and various consultative services, including pre-authorization and medical review. Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, EndoGastric Solutions was previously known as EsophyX, Inc. before its rebranding in January 2005.

Fast Pace Health provides primary and urgent care to the communities they serve. They provide treatments for minor injuries, skin conditions, and diagnostics. Their services include behavioral health, dermatology care, occupational health, physical therapy, orthopedic care, and telehealth services.

Dynavax Technologies Corporation is a biopharmaceutical company specializing in the development and commercialization of innovative vaccines. Its flagship product, HEPLISAV-B, is a recombinant adjuvanted hepatitis B vaccine approved for use in adults aged 18 years and older, targeting all known subtypes of the hepatitis B virus. The company utilizes its proprietary Toll-like Receptor Immune Modulation Platform to enhance both innate and adaptive immune responses. Dynavax is actively advancing its immuno-oncology portfolio and has several development-stage products, including SD-101 and DV281, aimed at various cancer indications. In addition, the company engages in multiple research collaborations to develop adjuvanted vaccines for infectious diseases, including COVID-19, partnering with organizations such as Clover Biopharmaceuticals, the University of Queensland, and the Coalition for Epidemic Preparedness Innovations. Established in 1996 and headquartered in Emeryville, California, Dynavax continues to expand its role in vaccine development.

Synergy Pharmaceuticals Inc., located in New York, NY, with laboratories in Doylestown, PA, is a biopharmaceutical company dedicated to the research and development of innovative therapies for gastrointestinal disorders. The company focuses on treating conditions such as chronic idiopathic constipation and irritable bowel syndrome with constipation, leveraging proprietary analogs of the human gastrointestinal hormone uroguanylin. Its lead product, plecanatide, is a once-daily tablet designed to alleviate symptoms associated with these chronic conditions. Additionally, Synergy is developing dolcanatide, aimed at addressing inflammatory bowel disease by enhancing the digestive process. The company's approach involves the use of a novel class of guanylate cyclase-C agonists to target difficult-to-treat gastrointestinal diseases.

Silk Road Medical, Inc. is a medical device company based in Sunnyvale, California, that specializes in innovative solutions for treating carotid artery disease. Founded in 2007, the company has developed a unique approach known as transcarotid artery revascularization (TCAR), which aims to reduce the risk of stroke and enhance patient safety during procedures. Silk Road Medical's product portfolio includes the ENROUTE Transcarotid Neuroprotection System, which allows for direct access to the common carotid artery while temporarily reversing blood flow to protect the brain. Additionally, the ENROUTE Transcarotid Stent System and the ENHANCE Transcarotid Peripheral Access Kit support the TCAR procedure by facilitating safe and effective treatment. Through its minimally invasive techniques, Silk Road Medical seeks to establish TCAR as the standard of care for carotid artery disease, demonstrating improved clinical outcomes and reduced complications associated with traditional methods.

Strongbridge Biopharma plc is a commercial-stage biopharmaceutical company dedicated to developing and commercializing therapies for rare diseases with significant unmet medical needs. The company’s primary focus is on rare endocrine disorders, exemplified by its product candidates, Recorlev, a cortisol synthesis inhibitor currently in Phase III trials for endogenous Cushing's syndrome, and Veldoreotide, a somatostatin analog that has completed Phase II trials for acromegaly. Strongbridge also offers Keveyis, an oral carbonic anhydrase inhibitor approved for treating specific forms of periodic paralysis in the United States. Founded in 1996 and headquartered in Trevose, Pennsylvania, the company aims to leverage a concentrated prescriber base for its products and plans to utilize a targeted sales force for marketing in the U.S., European Union, and other key markets. Additionally, Strongbridge seeks to enhance its portfolio through the in-licensing or acquisition of complementary products that align with its focus on rare endocrine conditions.

Strongbridge Biopharma plc is a commercial-stage biopharmaceutical company dedicated to developing and commercializing therapies for rare diseases with significant unmet medical needs. The company’s primary focus is on rare endocrine disorders, exemplified by its product candidates, Recorlev, a cortisol synthesis inhibitor currently in Phase III trials for endogenous Cushing's syndrome, and Veldoreotide, a somatostatin analog that has completed Phase II trials for acromegaly. Strongbridge also offers Keveyis, an oral carbonic anhydrase inhibitor approved for treating specific forms of periodic paralysis in the United States. Founded in 1996 and headquartered in Trevose, Pennsylvania, the company aims to leverage a concentrated prescriber base for its products and plans to utilize a targeted sales force for marketing in the U.S., European Union, and other key markets. Additionally, Strongbridge seeks to enhance its portfolio through the in-licensing or acquisition of complementary products that align with its focus on rare endocrine conditions.

EarLens is a privately held medical technology company focused on enhancing the hearing experience for individuals with hearing loss. The firm has pioneered the Earlens Contact Hearing Solution, a groundbreaking device that directly activates the natural hearing process. This innovative system utilizes low-frequency radio signals and a small lens placed on the eardrum to vibrate it, allowing for superior sound quality and a broader bandwidth than traditional hearing aids. Unlike conventional devices that amplify sound, the Earlens solution delivers sound directly to the eardrum, thereby minimizing feedback and ensuring clear hearing in various environments. The second generation of this technology received FDA clearance in 2019, marking a significant advancement in the standard of care for hearing performance.

EarLens is a privately held medical technology company focused on enhancing the hearing experience for individuals with hearing loss. The firm has pioneered the Earlens Contact Hearing Solution, a groundbreaking device that directly activates the natural hearing process. This innovative system utilizes low-frequency radio signals and a small lens placed on the eardrum to vibrate it, allowing for superior sound quality and a broader bandwidth than traditional hearing aids. Unlike conventional devices that amplify sound, the Earlens solution delivers sound directly to the eardrum, thereby minimizing feedback and ensuring clear hearing in various environments. The second generation of this technology received FDA clearance in 2019, marking a significant advancement in the standard of care for hearing performance.

Viveve Medical, Inc., established in 2005, specializes in designing, developing, manufacturing, and marketing medical devices for non-invasive treatment of women's health issues. Its primary product, the Viveve System, employs radiofrequency technology to address vaginal laxity, improve sexual function, and treat stress urinary incontinence. The company's products are sold through its own sales team and distributors in various regions worldwide, including the US, Europe, Asia Pacific, and Latin America. Viveve Medical is headquartered in Englewood, Colorado.

BioDelivery Sciences International, Inc. is a specialty pharmaceutical company headquartered in Raleigh, North Carolina, dedicated to addressing the needs of patients with chronic pain and opioid dependence. Founded in 1997, the company focuses on the development and commercialization of innovative pharmaceutical products, leveraging its proprietary BioErodible MucoAdhesive (BEMA) drug-delivery technology. This technology allows for the creation of small erodible polymer films designed for effective application to the buccal mucosa. BioDelivery Sciences offers a range of products, including BELBUCA, a buprenorphine buccal film for chronic pain management, and BUNAVAIL, a buprenorphine and naloxone buccal film aimed at treating opioid dependence. Additionally, it provides ONSOLIS, a fentanyl buccal soluble film for managing breakthrough pain in cancer patients, and Symproic, which treats opioid-induced constipation in adults with chronic pain. The company's focus on novel drug delivery methods enables it to address important unmet medical needs in pain management and addiction medicine.

Endoceutics is a biopharmaceutical company focused on women's health, particularly in the areas of hormone-sensitive cancer prevention and treatment. The company specializes in the development of hormone therapies aimed at addressing breast cancer and endocrine-related disorders. Endoceutics is dedicated to advancing basic sciences, clinical research, and the commercialization of its products, which are designed to enhance the quality of life for women facing menopausal issues. With a diverse portfolio of products at various stages of development, Endoceutics aims to provide effective, physiological, and non-negative treatment options that address the specific health needs of women.

Barricaid is a medical device company that specializes in developing therapeutic solutions for patients undergoing back surgery. Their primary product is a bone-anchored implant designed to reduce the incidence of reherniation and reoperation in patients with large annular defects. The implant works by physically blocking the annulus at the post-surgery defect, using a titanium alloy anchor component that secures the device in position within either the caudal or cranial-adjacent vertebral body. This innovative approach aims to improve outcomes for patients who are at high risk of requiring repeated surgeries due to herniation following lumbar discectomy surgery, particularly those suffering from sciatica.

Hicuity Health is a leading provider of high acuity telehealth services, delivering critical care solutions to over 115 hospitals across 30 states on a continuous basis. The company specializes in acute care telemedicine, offering services such as ICU programs and evidence-based protocols that utilize advanced tele-technology. By employing U.S. board-certified intensivists and operating multiple dedicated tele-care delivery centers, Hicuity Health enhances communication between physicians, nurses, patients, and onsite clinicians. This approach aims to improve patient outcomes and support hospitals in providing effective critical care.

T2 Biosystems, Inc. is an in vitro diagnostics company specializing in the rapid detection of pathogens and biomarkers to enhance patient care. The company employs its proprietary T2 Magnetic Resonance technology, which allows for the detection of various pathogens directly from unpurified patient samples, such as whole blood and urine, without the need for extensive sample preparation. T2 Biosystems offers several diagnostic products, including the T2Dx Instrument, which is designed to identify pathogens associated with sepsis and Lyme disease. Its product lineup includes the T2Candida Panel for detecting Candida species, the T2Bacteria Panel for identifying bacterial pathogens, the T2SARS-CoV-2 Panel for COVID-19 testing, and the T2Resistance Panel for detecting antibiotic resistance markers. Founded in 2006 and headquartered in Lexington, Massachusetts, T2 Biosystems aims to improve clinical outcomes and reduce healthcare costs by enabling faster and more accurate diagnostic testing.

Omeros Corporation is a Seattle-based biopharmaceutical company that focuses on discovering, developing, and commercializing small-molecule and protein therapeutics targeting inflammation, complement-mediated diseases, and disorders of the central nervous system. The company offers OMIDRIA, a product used during cataract surgery in the United States. Omeros is advancing several clinical programs, including narsoplimab, which is in Phase III trials for conditions such as hematopoietic stem-cell transplant-associated thrombotic microangiopathy and immunoglobulin A nephropathy, as well as Phase II trials for lupus nephritis. Other key programs include OMS405, targeting opioid and nicotine addiction, and OMS527, aimed at treating addiction and movement disorders. The company's preclinical pipeline includes compounds addressing various conditions, such as paroxysmal nocturnal hemoglobinuria and other alternative pathway disorders. Founded in 1994, Omeros is dedicated to addressing both large-market and orphan indications through innovative therapeutic approaches.

Access TeleCare is a provider of acute care telemedicine services designed for hospitals, health systems, post-acute providers, and physician networks. The company specializes in a range of telehealth services, including telecardiology, teleneurology, telepsychiatry, telepulmonology, telehospitalists, teleinfectious disease, and telematernal fetal medicine. By leveraging advanced technology, Access TeleCare facilitates virtual patient care, allowing healthcare organizations to develop and sustain telemedicine programs across various clinical specialties. The company's model supports healthcare providers in enhancing patient access to specialized care while maintaining quality and efficiency in service delivery.

US WorldMeds is a specialty pharmaceutical company based in Kentucky, focused on developing, licensing, and commercializing unique pharmaceuticals that address unmet medical needs. Founded in 2001 by CEO Paul Breckinridge "Breck" Jones, the company aims to create innovative treatments primarily for conditions such as Parkinson's disease, cervical dystonia, malignant hyperthermia, and other rare diseases. By leveraging local talent and expertise, US WorldMeds aspires to be a significant player in the pharmaceutical industry while maintaining its closely-held structure. The company is dedicated to improving the lives of patients and is committed to expanding its presence as a responsible corporate citizen, fostering innovation, and creating high-quality jobs in its headquarters in Louisville and its satellite offices and manufacturing facilities.

Iroko Pharmaceuticals, LLC is a specialty pharmaceutical company focused on developing and commercializing innovative products for pain management. Founded in 2007 and based in Philadelphia, Pennsylvania, the company offers a range of pharmaceutical products, including Indocid, Aldomet, TIVORBEX, ZORVOLEX, and VIVLODEX, which are primarily nonsteroidal anti-inflammatory drugs (NSAIDs) designed to address various types of pain, including osteoarthritis and acute pain in adults. Iroko leverages proprietary technology to create nano-formulated lower-dose NSAIDs, aiming to provide more effective and responsible pain relief options. The company has established a distribution and sales network that spans over 40 countries, emphasizing its commitment to extending the reach and benefits of its products in global markets.

Cardiome Pharma Corp. is a specialty biopharmaceutical company dedicated to the discovery, development and commercialization of new therapies that will improve the health of patients suffering from heart disease around the world. Cardiome has one marketed product, BRINAVESSTM (vernakalant IV), approved in Europe and other territories for the rapid conversion of recent onset atrial fibrillation to sinus rhythm in adults.

Valeritas Holdings, Inc. was a medical technology company focused on developing and commercializing innovative solutions for the treatment of Type 2 diabetes. Founded in 2006 and headquartered in Bridgewater, New Jersey, the company offered the V-Go, a wearable insulin delivery device designed for basal-bolus therapy, allowing patients to manage their insulin intake conveniently and discreetly. Valeritas was also working on additional products, including the V-Go Prefill, aimed at simplifying the device-filling process, and V-Go SIM, which would facilitate real-time tracking of dosing utilization. The company marketed its products through third-party wholesalers and medical supply distributors, aiming to enhance the health and quality of life for individuals living with diabetes. However, on June 30, 2020, Valeritas Holdings filed for Chapter 11 bankruptcy, leading to its cessation of operations.

Benvenue Medical, Inc. is a company specializing in the design, manufacture, and marketing of minimally invasive expandable implant systems for the treatment of spinal disorders, specifically vertebral compression fractures and degenerative disc diseases. Its product offerings include the Kiva system, which addresses spinal fractures in the thoracic and lumbar regions, and the Blazer – C system, designed for treating pathological vertebral compression fractures. Additionally, Benvenue Medical has introduced the Luna 3D, an expandable interbody fusion system suitable for various surgical approaches. The company serves a diverse customer base across the United States, Canada, Belgium, France, and Germany. Founded in 2004, Benvenue Medical is headquartered in Santa Clara, California, and is focused on developing innovative surgical solutions that enhance patient outcomes and restore spinal alignment.

Autonomic Technologies, Inc. is a medical device company that specializes in developing and commercializing innovative therapies for autonomic disorders, with a particular emphasis on severe headaches. Founded in 2007 and headquartered in Mountain View, California, the company has additional offices in Germany and Switzerland. Its flagship product, the ATI Neurostimulation System, is a miniaturized, battery-less microstimulator designed to deliver low-level energy directly to the sphenopalatine ganglion (SPG) to effectively treat chronic cluster headaches. This technology aims to set a new standard in the management of severe headaches and migraines, providing patients with a safe and effective treatment option.

EndoGastric Solutions, Inc. is a medical device company focused on developing and commercializing innovative surgical technologies for the treatment of gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). The company offers products such as EsophyX, which enables transoral reconstructive surgery, and the EsophyX Z device used in the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions provides SerosaFuse Fasteners, a non-resorbable polypropylene material with strength comparable to traditional sutures. Beyond its product offerings, the company supports healthcare professionals through trainer-led courses and various consultative services, including pre-authorization and medical review. Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, EndoGastric Solutions was previously known as EsophyX, Inc. before its rebranding in January 2005.

Silk Road Medical, Inc. is a medical device company based in Sunnyvale, California, that specializes in innovative solutions for treating carotid artery disease. Founded in 2007, the company has developed a unique approach known as transcarotid artery revascularization (TCAR), which aims to reduce the risk of stroke and enhance patient safety during procedures. Silk Road Medical's product portfolio includes the ENROUTE Transcarotid Neuroprotection System, which allows for direct access to the common carotid artery while temporarily reversing blood flow to protect the brain. Additionally, the ENROUTE Transcarotid Stent System and the ENHANCE Transcarotid Peripheral Access Kit support the TCAR procedure by facilitating safe and effective treatment. Through its minimally invasive techniques, Silk Road Medical seeks to establish TCAR as the standard of care for carotid artery disease, demonstrating improved clinical outcomes and reduced complications associated with traditional methods.

GenomeDx discovers, develops, and commercializes genomic-based laboratory tests for the personalized medicine revolution in cancer care. In partnership with physicians and scientists from leading academic medicine institutions, our mission is to bring cost-effective and high-resolution genomics for routine clinical use in cancer medicine.

Avinger, Inc. is a medical device company based in Redwood City, California, that specializes in developing catheter-based technologies for the treatment of peripheral arterial disease (PAD). Founded in 2007, Avinger designs, manufactures, and sells image-guided systems, including the Lightbox imaging console and the Ocelot family of catheters, which enable physicians to navigate and treat total blockages in arteries, known as chronic total occlusions (CTOs). The company's Pantheris device provides image-guided atherectomy, allowing for precise removal of arterial plaque in patients with PAD. Avinger's products are marketed to interventional cardiologists, vascular surgeons, and interventional radiologists, addressing significant needs in vascular health management.

ViewRay, Inc. is a medical technology company that specializes in designing, manufacturing, and marketing advanced radiation therapy systems for cancer treatment. Its flagship product, MRIdian, is a magnetic resonance image-guided radiation therapy system that simultaneously images and treats cancer patients. By integrating MRI technology with radiation delivery and proprietary software, MRIdian enhances the precision of radiation therapy. It can accurately locate and target soft-tissue tumors while minimizing exposure to surrounding healthy tissue. This capability allows clinicians to treat patients who might not have been suitable candidates for traditional radiation therapy, ultimately leading to improved safety and effectiveness in treatment outcomes. Headquartered in Oakwood, Ohio, ViewRay serves a diverse range of healthcare institutions, including university research hospitals, community hospitals, and freestanding cancer centers, and operates both domestically and internationally. The company was founded in 2004.

Outset Medical, Inc. is a medical technology company based in San Jose, California, focused on innovating dialysis solutions for patients and healthcare providers. The company has developed the Tablo system, a hemodialysis machine designed for both acute and chronic care settings. Tablo features a compact console with integrated water purification, on-demand dialysate production, and advanced connectivity capabilities, including wireless data and sensor-based automation. This design aims to simplify the complexities and costs associated with dialysis, making it suitable for use in hospitals, dialysis clinics, and home settings. Originally founded as Home Dialysis Plus, Ltd. in 2003, the company rebranded to Outset Medical, Inc. in January 2015.

Navidea Biopharmaceuticals, Inc. is a biopharmaceutical company dedicated to the development and commercialization of precision immunodiagnostic agents and immunotherapeutics. The company operates through two main segments: Diagnostic Substances and Therapeutic Development Programs. Central to its efforts is the Manocept platform, which targets the CD206 mannose receptor found on activated macrophages, enabling innovative approaches to diagnostic imaging and therapeutic delivery. This platform supports a variety of diagnostic modalities, including PET imaging, and is designed to address immune and inflammation-related diseases. Notably, Navidea offers NAV4694, a PET imaging agent for assessing Alzheimer’s disease and mild cognitive impairment. Additionally, the company is advancing other diagnostic substances and therapeutic programs, with a collaboration agreement in place with IMV Inc. to explore combined immunotherapeutic effects. Founded in 1983 and headquartered in Dublin, Ohio, Navidea Biopharmaceuticals previously operated under the name Neoprobe Corporation until 2012.

Ceterix Orthopaedics, Inc. is a medical technology company that specializes in developing innovative surgical tools for arthroscopic procedures. Founded in October 2010 and based in Fremont, California, Ceterix offers the NovoStitch® Plus Meniscal Repair System, designed to address complex meniscal tears, including horizontal, radial, and root tears. The company also provides the Novocut Suture Manager, a device that facilitates efficient suture management. Ceterix's technology enables orthopedic surgeons to create intricate suture patterns in tight joint compartments while safeguarding surrounding structures, such as nerves and cartilage. This advancement allows for improved outcomes in arthroscopic procedures across various joints, including the knees, hips, and shoulders. Ceterix was previously known as SuturePro Technologies, Inc. before rebranding in April 2011 and is currently a subsidiary of Smith & Nephew plc.

TearLab Corporation is an in-vitro diagnostic company based in Escondido, California, specializing in the development and marketing of innovative tear testing technologies for the diagnosis of dry eye disease. The company’s flagship product, the TearLab Osmolarity System, is a proprietary platform that allows eye care practitioners to measure tear film osmolarity and identify sensitive biomarkers using only nanoliters of tear film at the point-of-care. This system includes a disposable microfluidic chip, a hand-held device known as the TearLab Pen for sample collection, and the TearLab Reader, a desktop unit that provides quantitative results. Founded in 1996, TearLab aims to enhance the standard of care in ophthalmology through objective and precise testing methodologies.

Imaging Advantage is a prominent provider of advanced, evidence-based radiology solutions designed to enhance the efficiency and utilization of healthcare services across the United States. The company offers innovative, scalable cloud-based technology that integrates various information technology systems and employs clinical algorithms to align healthcare supply and demand. Imaging Advantage serves major healthcare systems in states including Arizona, California, Illinois, Michigan, Ohio, Oregon, and Texas, as well as in other significant metropolitan areas nationwide. By focusing on optimizing provider utilization, the company aims to improve the overall effectiveness of radiology services within the healthcare sector.

Imaging Advantage is a prominent provider of advanced, evidence-based radiology solutions designed to enhance the efficiency and utilization of healthcare services across the United States. The company offers innovative, scalable cloud-based technology that integrates various information technology systems and employs clinical algorithms to align healthcare supply and demand. Imaging Advantage serves major healthcare systems in states including Arizona, California, Illinois, Michigan, Ohio, Oregon, and Texas, as well as in other significant metropolitan areas nationwide. By focusing on optimizing provider utilization, the company aims to improve the overall effectiveness of radiology services within the healthcare sector.

Blue Belt Technologies, Inc. specializes in developing and commercializing robotics-assisted technologies for orthopedic surgery and other medical specialties. The company is known for its Navio surgical system, which combines handheld intelligent instruments with a CT-free registration and patient-specific planning process, enhancing the precision of surgical procedures. Additionally, Blue Belt offers the STRIDE unicondylar knee system, designed to address early-stage osteoarthritis in the knee. Their software applications assist surgeons in creating tailored implant plans for unicondylar and patellofemoral knee replacements, ensuring proper localization of components and soft-tissue balance. Beyond its technological offerings, Blue Belt provides support services, marketing resources, maintenance programs, and onsite training for healthcare professionals. Founded in 2003 and headquartered in Plymouth, Minnesota, Blue Belt Technologies became a subsidiary of Smith & Nephew in 2016.

Astute Medical, Inc. is a life science tools company focused on improving the diagnosis of high-risk medical conditions through the discovery and development of protein biomarkers. Founded in 2007 and based in San Diego, California, with an additional location in Paris, France, the company specializes in creating novel diagnostic tests that enable rapid diagnosis and risk assessment for conditions such as abdominal pain, acute coronary syndromes, cerebrovascular injury, kidney injury, and sepsis. Astute Medical's flagship product, NephroCheck, is a single-use cartridge designed to detect biomarkers associated with acute kidney injury, while the Astute140 meter converts the test's fluorescent signal into a single numerical result. The company markets its products primarily in the United States and Europe and operates as a subsidiary of bioMérieux S.A.

Nevro Corporation is a global medical device company specializing in innovative solutions for chronic pain management. Its primary product is the Senza spinal cord stimulation (SCS) system, which employs proprietary HF10 therapy to deliver evidence-based neuromodulation treatment. The Senza system consists of implantable components controlled by patients and managed by healthcare professionals using specialized software. Nevro generates a significant portion of its revenue in the United States.

Exagen Inc. is a commercial-stage diagnostics company focused on developing and commercializing innovative testing products for autoimmune and autoimmune-related diseases. Headquartered in Vista, California, Exagen utilizes its proprietary Cell-Bound Complement Activation Products technology to enhance diagnostic care for conditions like systemic lupus erythematosus and rheumatoid arthritis. The company offers a diverse portfolio of testing products under its AVISE brand, including AVISE CTD for differential diagnosis of connective tissue diseases, AVISE Lupus for monitoring complement system activation, and multiple panels for assessing various autoimmune markers. These products facilitate timely diagnosis and effective therapeutic interventions, enabling rheumatologists to improve patient care. Since its founding in 2002, Exagen has remained committed to addressing the needs of patients suffering from chronic autoimmune diseases.

AFT Pharmaceuticals Limited is a pharmaceutical company based in Auckland, New Zealand, that develops, licenses, and sells a diverse range of medical products. Established in 1997, the company offers approximately 130 prescription and non-prescription products, focusing on areas such as allergy relief, eye care, first aid, pain management, fungal treatments, and skin care, as well as dietary supplements. AFT Pharmaceuticals operates in multiple regions, including New Zealand, Australia, Southeast Asia, and other international markets, with a significant portion of its revenue generated from Australia. The company is also engaged in the distribution of pharmaceuticals, enhancing its presence in the healthcare sector through innovation and product development.

NanoString Technologies, Inc. is a life science company that specializes in providing innovative tools for translational research and molecular diagnostics globally. Founded in 2003 and headquartered in Seattle, Washington, the company developed a unique digital molecular barcoding technology for various applications in basic research and clinical diagnostics. Its flagship product, the nCounter Analysis System, consists of automated systems for sample preparation and data collection, allowing for the simultaneous profiling of numerous genes and proteins from single tissue samples. Additionally, NanoString offers the GeoMx Digital Spatial Profiler, which enhances spatial genomics research. The company also provides a range of services, including custom assay design, data analysis software, and molecular diagnostic test kits, such as Prosigna for breast cancer prognosis. Collaborations with major pharmaceutical companies and research institutions further bolster its position in advancing genomic and proteomic research.

Biodesix, Inc. is a diagnostic solutions company based in Boulder, Colorado, specializing in blood-based tests for lung cancer and related services. The company offers a range of diagnostic tests, including the Nodify XL2 and Nodify CDT tests, which assist physicians in assessing the risk of malignancy in patients with suspicious lung nodules. Additionally, Biodesix provides tumor profiling and immune profiling tests, such as GeneStrat and VeriStrat, to support timely treatment decisions for oncologists. These tests are processed in a CLIA-certified laboratory, with results typically available within 72 hours. Beyond its diagnostic offerings, Biodesix also engages in clinical research, development, and testing services for biopharmaceutical companies, focusing on the development and commercialization of companion diagnostics to enhance therapeutic efficacy. Established in 2005, Biodesix continues to advance its proprietary mass spectrometry-based discovery platform to improve patient outcomes in lung disease.

Solta Medical, Inc. is a medical device company specializing in energy-based systems for aesthetic applications. Founded in 1995 and headquartered in Hayward, California, the company designs, develops, and manufactures a range of products for skin rejuvenation and body contouring. Notable offerings include the Thermage NXT system, which provides non-invasive skin tightening and cellulite enhancement, as well as the Fraxel re:fine, re:store, and re:pair systems, which address various skin conditions such as fine lines, pigmentation, acne scars, and deeper wrinkles. These systems comprise handpieces, a user-friendly console, an energy source, and disposable treatment tips. Solta Medical serves a diverse clientele, including dermatologists, plastic surgeons, and gynecologists, and distributes its products through a direct sales force and a network of distributors both in the United States and internationally. The company was previously known as Thermage, Inc. before rebranding to Solta Medical in January 2009.

Exagen Inc. is a commercial-stage diagnostics company focused on developing and commercializing innovative testing products for autoimmune and autoimmune-related diseases. Headquartered in Vista, California, Exagen utilizes its proprietary Cell-Bound Complement Activation Products technology to enhance diagnostic care for conditions like systemic lupus erythematosus and rheumatoid arthritis. The company offers a diverse portfolio of testing products under its AVISE brand, including AVISE CTD for differential diagnosis of connective tissue diseases, AVISE Lupus for monitoring complement system activation, and multiple panels for assessing various autoimmune markers. These products facilitate timely diagnosis and effective therapeutic interventions, enabling rheumatologists to improve patient care. Since its founding in 2002, Exagen has remained committed to addressing the needs of patients suffering from chronic autoimmune diseases.

Exagen Inc. is a commercial-stage diagnostics company focused on developing and commercializing innovative testing products for autoimmune and autoimmune-related diseases. Headquartered in Vista, California, Exagen utilizes its proprietary Cell-Bound Complement Activation Products technology to enhance diagnostic care for conditions like systemic lupus erythematosus and rheumatoid arthritis. The company offers a diverse portfolio of testing products under its AVISE brand, including AVISE CTD for differential diagnosis of connective tissue diseases, AVISE Lupus for monitoring complement system activation, and multiple panels for assessing various autoimmune markers. These products facilitate timely diagnosis and effective therapeutic interventions, enabling rheumatologists to improve patient care. Since its founding in 2002, Exagen has remained committed to addressing the needs of patients suffering from chronic autoimmune diseases.

RainDance Technologies, Inc. specializes in developing advanced genomic tools for non-invasive liquid biopsy applications, focusing on cancer detection, treatment, and the study of inherited and infectious diseases. The company's flagship product, the RainDrop digital polymerase chain reaction platform, utilizes picoliter-sized droplets to facilitate multiplex detection of genetic material, including DNA and RNA. Additionally, RainDance offers the RainDrop Plus digital PCR system, which integrates next-generation sequencing (NGS) amplicon enrichment with digital PCR capabilities. Their automated ThunderStorm solution enhances NGS content enrichment, allowing laboratories to process multiple samples efficiently while ensuring high-quality data. The ThunderBolts panels target critical cancer mutations and specific genetic markers associated with myeloid disorders. RainDance's products include a range of consumables designed to optimize various laboratory processes. Founded in 2004 and headquartered in Billerica, Massachusetts, the company serves research institutions and laboratories globally through a network of sales representatives and distributors. RainDance Technologies operates as a subsidiary of Bio-Rad Laboratories, Inc.

Valeritas Holdings, Inc. was a medical technology company focused on developing and commercializing innovative solutions for the treatment of Type 2 diabetes. Founded in 2006 and headquartered in Bridgewater, New Jersey, the company offered the V-Go, a wearable insulin delivery device designed for basal-bolus therapy, allowing patients to manage their insulin intake conveniently and discreetly. Valeritas was also working on additional products, including the V-Go Prefill, aimed at simplifying the device-filling process, and V-Go SIM, which would facilitate real-time tracking of dosing utilization. The company marketed its products through third-party wholesalers and medical supply distributors, aiming to enhance the health and quality of life for individuals living with diabetes. However, on June 30, 2020, Valeritas Holdings filed for Chapter 11 bankruptcy, leading to its cessation of operations.

Good Start Genetics, Inc. is a molecular diagnostics company based in Cambridge, Massachusetts, founded in 2007. It specializes in genetic screening for inherited diseases, aiming to transform reproductive medicine by providing actionable information to physicians and patients. The company offers a range of services, including EmbryVu, a preimplantation genetic screening test designed to enhance in vitro fertilization outcomes by identifying suitable embryos for implantation. Additionally, Good Start Genetics provides a comprehensive array of genetic carrier screening tests through its GoodStart Select program, utilizing advanced next-generation DNA sequencing technology along with other established genetic screening methods. This focus on high carrier detection rates and commitment to customer care and genetic counseling positions the company as a leader in the field of pre-pregnancy genetic testing and diagnostics. As of August 2017, Good Start Genetics operates as a subsidiary of Invitae Corporation.

TriVascular Technologies, Inc. is a medical device company focused on developing and commercializing innovative technologies for the minimally invasive treatment of abdominal aortic aneurysms (AAA) and thoracic aortic aneurysms (TAA). Based in Santa Rosa, California, TriVascular specializes in endovascular grafts and self-expanding stent grafts, including the Ovation and Ovation Prime Stent Grafts, which utilize polymer-filled sealing rings to enhance procedural efficacy. The company’s products are designed to improve patient outcomes by reducing mortality, morbidity, and costs associated with traditional open surgical repair. TriVascular markets its technologies through direct sales in the United States and select European countries, as well as through distributors in other regions. Founded in 2007, TriVascular operates as a subsidiary of Endologix Inc. and emphasizes addressing unmet clinical needs while fostering a supportive work environment for its employees.

Tandem Diabetes Care, Inc. is a medical device company headquartered in San Diego, California, which specializes in the design, development, and commercialization of insulin delivery systems for individuals with insulin-dependent diabetes. Its flagship product, the t:slim X2 insulin delivery system, includes a pump, a 300-unit disposable insulin cartridge, and an infusion set. The company offers advanced features such as Basal-IQ Technology and Control-IQ Technology, along with the Tandem Device Updater for software enhancements. Additionally, Tandem provides the t:connect web-based data management application and the Sugarmate mobile app to support diabetes management for users and their caregivers. Tandem Diabetes Care entered the insulin pump market in 2012 and has since expanded its product line, including the recent launch of the smaller Mobi pump and development of a tubeless pump. The majority of the company’s revenue is generated in the United States, with additional sales from other developed countries.

Corium International, Inc. is a biopharmaceutical company based in Menlo Park, California, specializing in the development, manufacture, and commercialization of specialty pharmaceutical products utilizing transdermal and transmucosal delivery systems. The company offers several products, including the Clonidine Transdermal Delivery System for hypertension and Fentanyl Transdermal Delivery System for chronic pain management. Corium's pipeline includes the Twirla contraceptive patch, MicroCor hPTH(1-34) for osteoporosis, and transdermal systems for Alzheimer's disease treatment. Additionally, the company is developing Aripiprazole and Corplex Ropinirole patches targeting psychiatric disorders and Parkinson's disease, respectively. Corium has established collaborations with several pharmaceutical companies and aims to enhance therapeutic options in central nervous system healthcare. The firm has been operational since 1995 and continues to advance its innovative drug delivery technologies.

Bioniche Pharma Group manufactures and markets sterile injectable pharmaceutical products.