Signet Healthcare Partners

Leon Nanodrugs is a specialized product development company focused on enhancing existing drug formulations through nanotechnology. The company develops a pipeline of next-generation nano-formulated drugs that improve the bioavailability of poorly water-soluble medications. Utilizing its proprietary MJR® Technology platform, Leon Nanodrugs creates either polymeric or crystalline nanoparticles designed to offer significant differentiation and added benefits for patients. In addition to its drug development efforts, the company provides services that support pre-clinical and clinical stage formulations for clients, including new chemical entities and established branded drugs. Through its innovative approach, Leon Nanodrugs aims to improve patient outcomes in the pharmaceutical industry.

Curida is a pharmaceutical contract development and manufacturing organization that specializes in the production of liquid medicines. The company employs unit-dose Blow-Fill-Seal technology, which enhances product quality and ensures a streamlined manufacturing process with minimal human intervention. In addition to Blow-Fill-Seal products, Curida also manufactures nasal sprays and bottled solutions. By focusing on these specialized services, Curida aims to provide healthcare providers with reliable and tested pharmaceutical products tailored for diverse patient needs.

Paragonix Technologies is a medical device company focused on creating innovative organ preservation and transport systems aimed at improving the quality of transplant organs. Their devices ensure the security and preservation of donor organs by maintaining a consistent thermal environment and monitoring real-time location. Additionally, Paragonix offers a centralized platform for managing logistics related to organ transportation, which aids healthcare providers in enhancing organ preservation and improving post-transplant outcomes. The company's commitment to developing user-friendly organ preservation technologies addresses critical needs in transplantation medicine.

Laxai Pharma is a Contract Research Organization that provides integrated services across the drug discovery and development spectrum. With facilities in the United States and India, Laxai Pharma supports biopharmaceutical and agrochemical companies by offering a range of services, including medicinal chemistry, biology, process research and development, analytical services, clinical research, and strategic resourcing. The company aims to facilitate clients' drug discovery and development initiatives through advanced technology platforms and quality control systems, along with custom manufacturing and toxicology studies. Laxai Pharma's innovative global partnership models enhance its value proposition, enabling clients to navigate the complexities of the pharmaceutical and biotechnology industries effectively.

Juno Pharmaceuticals is a pharmaceutical company that specializes in the production and distribution of generic and specialty injectable medications. The company focuses on niche markets, offering products such as amoxicillin, hydrochloride syringes, hydromorphone solutions, and phentermine tablets and capsules. Juno Pharmaceuticals is dedicated to providing low-cost pharmaceutical options to medical clinics and hospitals while also promoting smaller brand products through contracted physician partnerships. Its emphasis on injectable drugs positions it as a key player in the market for essential generic medications.

Ascendia Pharmaceuticals is a contract development and manufacturing organization that focuses on enhancing drug formulations for preclinical and clinical-stage candidates, as well as marketed products. The company specializes in improving the solubility and bioavailability of poorly water-soluble drugs through its innovative nanotechnology platforms. Ascendia offers a range of services including pre-formulation, formulation development, manufacturing, and stability testing for injectable, oral, and topical dosage forms. Its three core technology platforms—EmulSol, AmorSol, and NanoSol—enable the production of nano-emulsions, amorphous solid dispersions, and nanoparticles, respectively. Additionally, Ascendia provides analytical method development and validation services to support its clients in addressing complex drug delivery challenges.

GI Supply, Inc. is a manufacturer of specialized medical products designed for gastroenterologists, colorectal surgeons, and interventional radiologists. Founded by Dr. Frank Jackson in 1982, the company is headquartered in Mechanicsburg, Pennsylvania. Its product lineup includes endoscopic tattoo agents, submucosal lifting agents, endoscopic injection needles, and paracentesis management systems, among others. These products are developed in collaboration with healthcare professionals to address clinical challenges and enhance both physician efficiency and patient satisfaction. Today, GI Supply's innovative solutions are utilized daily by medical practitioners in over 40 countries worldwide.

Smart Medical Systems Ltd. is a company based in Ra’anana, Israel, specializing in the development, manufacturing, and commercialization of medical devices for gastroenterology and gastrointestinal endoscopy. The company offers a range of innovative products, including the G-EYE endoscope, which enhances polyp detection rates during colonoscopy through its unique Controlled Withdrawal technique. This approach improves visibility and facilitates easier, faster therapeutic interventions. Additionally, Smart Medical Systems has developed the NaviAid Platform and various balloon devices designed for ileoscopy and colonoscopy, as well as inflation systems that support these applications. The company aims to provide cost-effective solutions that enhance the practice of gastrointestinal endoscopy for both healthcare professionals and patients. It distributes its products through partners in the United States and Europe and is recognized for its commitment to quality, holding ISO 13485:2003 certification from European regulatory authorities.

Leading Pharma, LLC is a privately owned company based in Fairfield, New Jersey, specializing in the manufacture, marketing, and distribution of generic pharmaceutical products. Established in 2014, the company develops, purchases, and licenses a variety of products, particularly oral solid dosage forms, across multiple therapeutic areas. Leading Pharma supplies its offerings to a diverse clientele, including wholesalers, distributors, drugstore chains, mass merchandisers, government agencies, and managed care accounts throughout the United States. The company's commitment to quality is reflected in its focus on providing safe and effective pharmaceutical products while adhering to stringent regulatory standards. Through efficient manufacturing processes and comprehensive customer service, Leading Pharma aims to enhance access to essential healthcare products for the communities it serves.

TELA Bio, Inc. is a medical technology company based in Malvern, Pennsylvania, established in 2012. The company specializes in the design, development, and marketing of tissue reinforcement materials aimed at addressing unmet needs in soft tissue reconstruction. TELA Bio offers a range of products, including the OviTex Reinforced Tissue Matrix, which is utilized in hernia repair and abdominal wall reconstruction, and the OviTex PRS Reinforced Tissue Matrix, designed for plastic and reconstructive surgery. Additionally, TELA Bio provides OviTex products specifically for laparoscopic and robotic-assisted surgical procedures, which are derived from ovine rumen and incorporate polypropylene fiber. The company's marketing efforts are primarily focused in the United States, utilizing a direct sales force to promote its innovative solutions in soft tissue repair.

Pharmaceutics International, Inc. is a contract development and manufacturing organization specializing in dosage form development and cGMP manufacturing services for the biotech and specialty pharmaceutical sectors, both in the United States and internationally. Established in 1994 and headquartered in Hunt Valley, Maryland, the company produces a diverse array of dosage forms, including conventional and controlled-release tablets, soft gels, inhalation products, sterile injectables, and various liquid formulations. Additionally, Pharmaceutics International offers comprehensive services such as pre-formulation, clinical trial materials manufacturing, commercial manufacturing, and clinical packaging and labeling. With a focus on enhancing drug quality and patient outcomes, the company employs advanced technologies for bioavailability enhancement and provides regulatory and project management support to its clients, thereby minimizing risks in drug development.

Leon Nanodrugs is a specialized product development company focused on enhancing existing drug formulations through nanotechnology. The company develops a pipeline of next-generation nano-formulated drugs that improve the bioavailability of poorly water-soluble medications. Utilizing its proprietary MJR® Technology platform, Leon Nanodrugs creates either polymeric or crystalline nanoparticles designed to offer significant differentiation and added benefits for patients. In addition to its drug development efforts, the company provides services that support pre-clinical and clinical stage formulations for clients, including new chemical entities and established branded drugs. Through its innovative approach, Leon Nanodrugs aims to improve patient outcomes in the pharmaceutical industry.

BionPharma, based in Princeton, New Jersey, with additional offices in Raleigh, North Carolina, specializes in the development and commercialization of affordable quality generic pharmaceuticals. Founded in 2014 by a team of experienced professionals from the generics industry, the company is known for its expertise in product development, regulatory affairs, quality management, sales and distribution, and supply chain management. BionPharma has established itself as one of the largest suppliers of soft gel capsules in the United States, serving both prescription and over-the-counter markets. Through its commitment to building strong partnerships, BionPharma enables clients to access a wide range of generic pharmaceutical products efficiently.

KEW Group is a personalized oncology management company based in Cambridge, Massachusetts, founded in 2009. It specializes in DNA-based genomic testing and interpretation services, aiming to enhance cancer care through individualized treatment options. By leveraging proprietary oncology therapeutic pathways and personalized medicine tools, KEW Group utilizes genetic and genomic information to inform clinical decision-making in community oncology settings. The company's focus is on identifying genetic variants in solid tumors and matching them with targeted therapies, thereby improving treatment decisions and the overall quality of patient care. KEW Group is committed to advancing oncology precision medicine and expanding the capabilities of molecular labs in the field.

Sancilio and Company, founded in 2004 and headquartered in Riviera Beach, Florida, specializes in the development, manufacturing, and distribution of biopharmaceutical products, including over-the-counter items and dietary supplements. The company offers a range of products targeting cardiovascular health, dental health, and women's health. Notable offerings include OCEAN BLUE PROFESSIONAL OMEGA-3 for cardiovascular support and LUDENT SODIUM FLUORIDE CHEWABLE TABLETS for children's dental health. Sancilio also provides a variety of women's health products, such as Mylk, a multivitamin softgel, and Caltranate, a calcium supplement. In addition to its product lines, the company offers pharmaceutical services, encompassing analytical chemistry, formulation development, and contract manufacturing, among others. Despite its comprehensive portfolio, Sancilio and Company filed for Chapter 11 bankruptcy and ceased operations as of May 31, 2019.

Fluxion Biosciences develops analytical instruments for functional cellular analyses, targeting applications in life sciences, drug discovery, and diagnostics. The company offers a range of products, including the IsoFlux Liquid Biopsy System, which enriches rare cell populations such as circulating tumor cells, and various enrichment and downstream analysis kits. Additionally, Fluxion provides BioFlux systems for live cell analysis under shear flow, catering to fields like immunology and cancer research, as well as IonFlux systems for automated patch clamping. Founded in 2005 and based in Alameda, California, Fluxion also offers analytical services for circulating tumor cell and liquid biopsy applications, serving biotechnology and pharmaceutical companies, academic institutions, and government research organizations through a global network of distributors.

Arbor Pharmaceuticals is a specialty pharmaceutical company based in Raleigh, North Carolina, founded in 2006. It primarily focuses on pediatric medicine, licensing, developing, and commercializing late-stage products designed for common pediatric conditions. The company offers a range of products, including ZINOTIC and ZINOTIC ES for treating Acute Otitis Externa, NEOTIC for pain and inflammation associated with Acute Otitis Media, and XYLAREX for dietary management of Recurrent Acute Otitis Media. Additionally, Arbor Pharmaceuticals provides the Pediaderm HC Complete Kit, specifically formulated to treat and protect the skin of children with atopic dermatitis, commonly known as eczema. The company markets its products through specialized sales forces across the United States, while also engaging in research and development in therapeutic areas like cardiology, neurology, and endocrinology.

Pfenex Inc. is a biotechnology company based in San Diego, California, specializing in the development of protein therapies to address unmet medical needs. The company is known for its lead product candidate, PF708, which is a therapeutic equivalent to Forteo for treating osteoporosis. Other notable candidates include PF743, a recombinant crisantaspase, and PF745, an extended half-life version of the same protein. Pfenex is also advancing PF810, a next-generation therapeutic in preclinical development, along with additional products such as sparX-1 and sparX-2. The company's innovative Pfēnex Expression Technology, which employs the microorganism Pseudomonas fluorescens, facilitates the rapid and efficient production of therapeutic proteins, vaccines, and biosimilars. Pfenex also holds license and supply agreements for CRM197, a non-toxic variant of diphtheria toxin. As of late September 2020, Pfenex operates as a subsidiary of Ligand Pharmaceuticals Incorporated.

SpePharm is a European specialty pharmaceutical company focused on acquiring, registering, and marketing high-value medicines primarily for the hospital market. The company specializes in oncology, hematology, and supportive care, offering medical products that assist clinicians in managing oral complications associated with radiotherapy or chemotherapy. SpePharm's management team possesses extensive global experience in the pharmaceutical sector, particularly with a deep understanding of the European regulatory landscape and the nuances of niche and orphan products. Their expertise allows them to implement innovative strategies and achieve notable successes in the field.

PEAK Surgical is a medical device company based in Palo Alto, California, focused on developing surgical tools that enhance precision and control during surgical procedures. The company's flagship product, the PEAK Surgery System, includes a range of disposable cutting devices designed to provide the accuracy of a scalpel combined with the bleeding control typical of traditional electrosurgery, while minimizing collateral damage to surrounding tissues. This innovative technology addresses a significant need in the surgical market, making it suitable for various applications, including general, plastic, reconstructive, ENT, gynecologic, orthopedic, arthroscopic, spinal, and neurological surgeries in the United States, as well as general surgery in the European Union.

Direvo Industrial Biotechnology GmbH, founded in 2008 and based in Cologne, Germany, specializes in developing and marketing biology-based products and processes for non-pharmaceutical industries. The company focuses on providing bio-based solutions in clean energy, clean chemistry, and biomass conversion markets by leveraging its expertise in enzymes and microbes. Its BluZy platform features technologies tailored for the grain ethanol industry, enhancing both the nutritional value of by-products and the efficiency of ethanol production processes. Additionally, the BluServ platform offers automated high-throughput screening for protein and strain engineering, while the BluCon technology facilitates the conversion of non-food feedstocks into carbohydrates for fuel and chemical production. Direvo collaborates with major industry players and is privately owned, with investments from various equity partners and private investors.

Alpex Pharma SA is a pharmaceutical company based in Mezzovico-Vira, Switzerland, specializing in the research, development, and production of orally dispersible tablets, including fast melt and effervescent formulations. Established in 1983, the company has developed proprietary technology for producing these tablets, making it a significant player in this niche market. Alpex Pharma also offers a range of development services, such as drug-excipient compatibility studies, analytical method development, and stability studies. Its state-of-the-art manufacturing and research facilities span approximately 7,000 square meters and comply with GMP standards for both pharmaceutical and nutritional products. Through its innovative approach and advanced capabilities, Alpex Pharma aims to enhance the convenience and effectiveness of medication delivery for healthcare professionals.

Atlantis Components specializes in the design and manufacturing of titanium abutments for dental implants. The company has developed a software system called the Virtual Abutment Design (VAD) system, which enables technicians to create abutments with unprecedented precision and certainty in the field of implant dentistry. Atlantis Components' designs are informed by extensive dental research and clinical input, allowing dentists to effectively restore implants using crown-and-bridge techniques. The consistent application of the VAD system ensures high-quality outcomes for both single and multiple unit cases, positioning Atlantis Components as a leader in dental implant solutions.

Cedarburg Hauser Pharmaceuticals is an experienced contract development and manufacturing organization (CDMO) for active pharmaceutical ingredients (APIs) and intermediates We offer multiple sites for non-GMP R&D projects, GMP kilo labs for early phase projects and GMP plant capacity for late stage and commercial APIs. We apply our drug development experience and expertise to help our clients successfully advance their drug candidate from early preclinical evaluations through clinical trials and eventually to market.