Founded by Darcy Howe in 2016, KCRise Fund is a venture capital firm based in Kansas City, Missouri. It invests alongside other institutional investors in early-stage companies located in Kansas and the western half of Missouri. The fund focuses on sectors such as software, TMT, B2B products/services, energy, financial services, healthcare, and information technology.

Founded in 2014, Flyover Capital is a venture capital firm based in Overland Park, Kansas. It invests in early-stage technology-related companies across the United States, with a focus on B2B sectors such as finance, insurance, logistics, real estate, and cybersecurity software.

Founded in 2013, Stray Dog Capital is a venture capital firm based in Leawood, Kansas. It specializes in early-stage investments, focusing on businesses that drive alternatives to the use of animals in the supply chain across food, beverage, and biotechnology sectors in the United States and Europe.

Mid-America Angels is a business angel group founded in 2006 and headquartered in Fairway, Kansas, with additional offices in Lenexa and Lawrence, Kansas. The organization focuses on funding start-up and early-stage companies primarily in the Kansas-Missouri region and within a 150-mile radius of Kansas City. It engages a network of accredited investors to identify and finance opportunities, typically participating in seed, Series A, and Series B funding rounds. Mid-America Angels aims to invest between $250,000 and $1,500,000 in promising ventures, and may consider investments outside its primary geographic area in collaboration with other angel networks or investment organizations. The group's structure allows it to leverage the collective knowledge, experience, and capital of its members to support the growth of emerging businesses.

The Kansas Bioscience Authority is a venture capital provider focused on advancing bioscience innovations across various sectors, including agribusiness, animal health, human health, and life sciences technology. With the largest concentration of animal health companies globally, Kansas serves as a hub for groundbreaking research in oncology, information technology, medical devices, and other critical areas impacting human health. The authority leverages the state's strong agricultural heritage to foster advancements that benefit both the bioscience industry and the broader economy.

Nueterra Capital is a venture capital investment firm based in Leawood, Kansas, founded in 1997. The firm focuses on investing exclusively in early and growth-stage healthcare companies, aiming to empower entrepreneurs by providing them with the necessary capital, resources, and expertise to drive innovation in the healthcare sector. By aligning its investments with the needs of these companies, Nueterra Capital facilitates business expansion and the creation of new growth opportunities. In addition to healthcare, the firm has interests in consumer products and services, real estate, and technology sectors.

Leawood Venture Capital, established in 2016, is a Kansas-based private equity firm specializing in early-stage investments in tech companies across the United States. With a team comprising successful founders and experienced business operators, the firm leverages its extensive market and technology expertise to add value to its portfolio. Focusing on sectors such as technology, artificial intelligence, and cybersecurity, Leawood Venture Capital has invested in over 25 companies since its inception.

Founded in 2008, OPENAIR Equity Partners is a venture capital firm focused on early-stage investments in mobile/wireless and connected device startups within the technology sector.

Linseed Capital is an angel investment firm founded in 2005 and based in Omaha, Nebraska. It focuses on investing in startups primarily within the Midwest region of the United States.

Founded in 2022, Iron Prairie Ventures is a venture capital firm based in Leawood, Kansas. It invests in industrial technologies with the potential to drive innovation and progress across manufacturing, infrastructure, construction, supply chain, and logistics sectors.

Abstraction Capital, established in 2020 and headquartered in Kansas City, Missouri, is an early-stage venture capital firm. It specializes in investing in pre-seed or seed rounds for software companies developing technical tools, APIs, and infrastructure that enhance developer productivity and streamline software workflows. The firm's portfolio includes companies building open-source tools, low-code platforms, and solutions for software observability and DevOps.

NQV8 is a venture capital firm founded in 2017 and based in Manhattan, Kansas. The firm specializes in making equity investments in the pet industry, with a particular focus on innovations in pet food. By targeting emerging trends and advancements within this sector, NQV8 aims to support and promote the growth of businesses that enhance the quality of products and services available for pets.

Founded in 2017, Koch Disruptive Technologies is a venture capital firm based in Wichita, Kansas. It invests in promising entrepreneurs and technologies across industries to improve Koch Industries' existing businesses and create new opportunities.

Serra Ventures is a venture capital firm based in Champaign, Illinois, that invests in technology companies across the United States and select international locations. The firm concentrates on early-stage and growth opportunities in information technology, deep technology, instrumentation, software as a service, devices, B2B, and agricultural technologies, with a focus on the Midwest and West Coast regions. Serra Ventures supports portfolio companies through strategic guidance, networks, and resources to help scale technology-enabled businesses.

Blackbird Ventures is a venture capital firm based in Sydney, Australia, that provides seed-to-late-stage funding to startups across Australia and New Zealand. The firm invests in technology-driven companies spanning software, hardware, space, healthcare, consumer products, autonomous robotics, artificial intelligence, infrastructure, clean energy, and quantum technology, supporting them from early idea stages through growth.

Founded in 2016, Morpheus Ventures is a venture capital firm headquartered in Los Angeles. It invests in early-stage companies operating across various sectors including data analytics, machine learning, robotics, transportation, SaaS, fintech, insurtech, proptech, and selected frontier technologies.

Founded in 2009, Werth Ventures is a family office that invests in seed to late-stage healthcare companies. Its focus areas include pharmaceuticals, biotechnology, medical devices, and diagnostics.

Prospect Capital Corporation is a publicly traded business development company that provides flexible private debt and equity capital to sponsor-owned and non-sponsor-owned middle-market companies in the United States and Canada. It originates and manages a range of investments, including secured and unsecured term loans, mezzanine debt, private debt and equity, and real estate investments (notably multifamily housing). It supports growth, acquisitions, recapitalizations and restructurings, often through sponsor-backed transactions as well as direct lending to owner-operated businesses. The firm targets middle-market opportunities across industries, with a history of financing across energy, industrials, and other sectors, and pursues both primary origination and secondary loan portfolios. It aims to deliver steady, attractive returns to shareholders by providing capital across the capital structure and leveraging a diversified investment approach.

Ulu Ventures is a Palo Alto, California-based seed and early-stage venture capital firm that backs technology-driven startups across the United States. Founded in 2008, it focuses on internet-enabled consumer and business services and a broad range of sectors including EdTech, FinTech, healthcare, sustainability, enterprise IT, SaaS, IoT, digital media, mobile, agtech, and marketplaces. The firm emphasizes backing diverse entrepreneurial teams and typically engages in co-investments with other investors to pursue meaningful exits. It is described as the first Latina-led venture fund in Silicon Valley and is among the larger seed-focused vehicles in the region.

Founded in 2017, RET Ventures is a venture capital firm focused on real estate technology. It invests in innovative startups operating within the multifamily and single-family rental industries. The firm connects these companies with its strategic network of property owners, providing early access to effective tech solutions while helping entrepreneurs scale their businesses.

Service Provider Capital is a venture capital firm established in 2014 and based in Colorado. The firm focuses on early-stage investments, notably seed-stage opportunities, and participates as a co-investor in Series A rounds led by institutional venture funds. Its portfolio interests span a broad range of technology sectors, including artificial intelligence, machine learning, blockchain, cybersecurity, e-commerce, education technology, fintech, hardware, information technology, robotics, health, and cannabis.

Index Ventures is a venture capital firm with offices in London, San Francisco, and Geneva that backs technology-driven startups worldwide. Since 1996 it has partnered with entrepreneurs to turn bold ideas into global businesses, investing across early and growth stages in sectors such as artificial intelligence, software, data, fintech, healthcare, media, mobility, security, and open source. The firm focuses on high-technology and life sciences and supports portfolio companies to scale internationally. Notable portfolio companies include Adyen, Deliveroo, Dropbox, Farfetch, King, Slack, and Supercell.

Avanta Ventures, LLC is a corporate venture capital firm established in 2017 and based in Mountain View, California. As a division of California State Auto Group, it focuses on investing in startups within the insurance technology sector and adjacent markets, including mobility, customer experience, connected home, artificial intelligence, analytics, and blockchain. Avanta Ventures aims to provide not only financial support but also industry expertise and resources to help startups accelerate their growth and achieve product-market fit. The firm offers a structured program, Avanta Studios, which includes funding and a curriculum tailored to enhance B2B engagement and practical learning through interaction with both internal and external experts.

An early-stage venture capital firm investing $100k-$250k in US-based B2B Vertical SaaS and FinTech companies, focusing on principled entrepreneurs solving real problems.

MatterScale Ventures is a venture capital firm founded in 2019 and based in New York, New York. It was established by former Endeavor executives and focuses on backing early-stage startups, aiming to bridge the seed-stage funding gap for Latin American founders. The firm supports companies headquartered in Latin America and the United States across sectors including education, healthcare, technology, financial services, housing, security, and employability.

TechNexus Venture Collaborative is a Chicago-based venture collaboration platform and investment entity that connects corporations with startups to co-create new business models, products, revenue streams, and scalable market access. Founded in 2007, it combines capital investment, incubation, and collaborative engagement to accelerate opportunities and support the growth of innovative ventures across sectors including audio and consumer electronics, B2B software, health and wellness, manufacturing, mobility, media production, and retail. It has facilitated partnerships between dozens of corporations and more than 600 startups, making it one of the most active venture investors in the United States.

Airtree Ventures is a Sydney-based venture capital firm that backs technology startups in Australia and New Zealand. It focuses on early-stage investments and leverages its network to help founders accelerate product development and growth, guiding ideas from concept to market. Its portfolio includes notable technology companies such as Canva, Go1, Employment Hero, Pet Circle, Immutable and Linktree.

Founded in 2015, Valor Ventures is a venture capital firm based in Atlanta, Georgia. It specializes in investing in early-stage companies led by underrepresented founders, with a focus on the Southeast region of the United States. The firm primarily invests in sectors such as software, fintech, and health tech, typically leading seed rounds and investing between $1 million to $2 million.

Tiger Global Management is a New York based investment firm that manages public and private market strategies to pursue technology-driven growth opportunities worldwide. Founded in 2001 by Charles (Chase) Coleman, the firm invests in leading global companies across various industries, with a particular emphasis on technology-enabled growth. In public markets it employs long/short and growth strategies, while in private markets it targets opportunities from early to late stage. The firm operates globally, including the United States, China, India, Latin America, and Eastern Europe, and works with portfolio companies across their lifecycle to drive long-term value.

Founded in 2005, Missouri Technology Corporation is a venture capital firm based in Jefferson City, Missouri. It invests in early-stage companies located within the state, focusing on industries such as life sciences, animal health, applied engineering, biomedical science, defense & homeland security, plant science, and technology.

A venture capital and private equity firm founded in 2012, headquartered in Park City, Utah, with an office in Kansas City, Missouri. It focuses on early‑stage investments in technology and technology‑enabled startups, as well as retail, consumer goods, and health and wellness, primarily in the Mountain West, Midwest, Pacific Northwest, and California. The firm typically invests between $0.1 million and $1 million in seed and early rounds ranging from $0.75 million to $5 million, and takes director seats to help shape boards. It targets under‑capitalized markets and seeks to provide strategic guidance to its portfolio companies.

M25 is a Chicago-based venture capital firm established in 2015 by Victor Gutwein and Mike Asem, focused on funding pre-seed and seed-stage technology startups in the Midwest. The firm supports portfolio companies across multiple industries, with a regional footprint spanning 24 Midwest cities in 11 states. Since its inception, M25 has backed more than 90 early-stage tech startups, aiming to accelerate growth and strengthen the Midwest startup ecosystem.

Founded in 2014, Gaingels is a venture investment syndicate dedicated to supporting the LGBT+ community. It invests globally in companies led by LGBT+ founders or C-suite executives at all stages of growth, focusing on inclusivity and positive social change.

IGNIA is a Mexico-based venture capital firm founded in 2007 that invests across early to growth stages in Latin America, focusing on health, financial services, education and technology companies. It targets ventures that serve low-income populations and address basic services such as healthcare, housing, water and energy, and prefers sectors like fintech, SaaS, edtech, healthtech, e-commerce and marketplaces. Investments are primarily in equity, with occasional subordinated debt or convertible debt structures, and the firm pursues co-investments with other investors. The firm concentrates on opportunities in Mexico and Latin America and supports high-growth enterprises at the base of the pyramid, including B2C businesses, seeking to generate positive social impact alongside financial returns.

Founded in 1987, Canaan Partners is a global venture capital firm based in Menlo Park, California. With over $5 billion under management, the firm invests in early-stage technology and healthcare companies worldwide.

FCA Venture Partners is a venture capital investment firm based in Nashville, Tennessee, established in 1996. It focuses on investing in healthcare and related technology companies at seed to later stages, frequently committing 3 to 6 million dollars per investment. The firm seeks to accelerate growth by funding healthcare products, services, and software that streamline processes, enhance quality of care, and improve the patient experience. It maintains deep ties to the Nashville healthcare community and has historical links with Clayton Associates and the McWhorter family, reflecting its local roots and collaborative approach to building sustainable healthcare businesses.

Goodwater Capital is a California-based venture capital firm founded in 2014 that targets early-stage investments in consumer technology and related sectors, including housing, financial services, consumer products and services, healthcare, food, transportation, education, and entertainment. It backs exceptional entrepreneurs who create products and platforms that consumers love, with a focus on solving pressing problems and shaping the culture and global economy. Through its investments, Goodwater aims to enable startups capable of delivering broad, measurable improvements in billions of lives, reflecting a commitment to long-term positive impact.

McKesson Ventures is the corporate venture capital arm of McKesson Corporation that invests in healthcare technology and services companies across early to growth stages. Based in San Francisco, it seeks minority investments to support digital health and technology-enabled services that improve healthcare delivery for pharma, pharmacy, providers, and patients. The firm targets opportunities in healthcare information technology, health tech, and healthcare systems, with a focus on innovative direct-to-consumer health care and new clinical services, aiming to back ventures that enhance efficiency and care outcomes across the health care economy.

Battery Ventures is a technology-focused investment firm founded in 1983 and based in Boston, Massachusetts. It engages in venture capital and private equity investments in technology companies, with emphasis on software (including application and infrastructure software), IT infrastructure technologies, consumer internet and mobile services, industrial technologies, and life science tools. The firm seeks to back category-defining businesses with potential for scalable growth, often supporting companies through multiple stages and across select global regions.

City Light Capital is a New York-based venture capital firm founded in 2004 that invests in seed, early, and growth-stage companies across technology, education, digital health, climate, food, wellness, energy, agriculture, safety and care, and the environment in the United States. It emphasizes impact investing, partnering with experienced teams to build category-defining solutions in education, safety and care, and the environment, aiming to scale revenue in ways that improve lives. Notable portfolio companies include 2U, ShotSpotter, Trilogy Education, and Ready Responders.

Founded in 2015, Lewis & Clark Ventures is a St. Louis-based venture capital firm focusing on early-stage investments in B2B software and healthcare technology sectors. They aim to be a trusted partner for entrepreneurs, supporting them in scaling their businesses.

Firebrand Ventures is a venture capital firm founded in 2016 and based in Kansas City, Missouri, with additional offices in Austin and Boulder. It concentrates on early-stage investments in software and technology startups, with a preference for companies in the United States and Canada and for opportunities arising in communities underserved by traditional venture capital. The firm supports early-stage companies as they scale, focusing on software and technology sectors.

Georgian Partners is a Toronto-based venture capital firm founded in 2008 that invests in expansion and later-stage information-intensive software and information-aggregation companies. The firm combines capital with a team of globally sourced operators to support portfolio growth, helping software businesses scale by leveraging data in a trustworthy way. Its focus is on business-to-business software, with an emphasis on data-driven growth and operational expertise to accelerate North American companies that rely on information-intensive software.

WestCap is a strategic investment firm that partners with leaders to build enduring businesses. With offices in New York, San Francisco, and London, they invest across sectors including technology, fintech, real estate tech, healthtech, and asset-light marketplaces.

Dolby Family Ventures is a San Francisco-based venture capital firm founded in 2014 that focuses on early-stage technology companies and life sciences. It invests in seed and Series A rounds, often through syndicates, and supports portfolio companies with follow-on rounds. The firm backs opportunities across biotechnology, neuroscience, life sciences, information technology software, security, digital media, cloud services, connected devices, digital deep tech, aerospace, climate tech, and healthcare technology. Typical investments range from hundreds of thousands in seed deals to several million dollars in later rounds, reflecting a broad mandate to partner with innovators and help portfolio companies scale.

Founded in 1863, Mayo Clinic is a non-profit organization based in Minnesota, United States. It provides comprehensive medical care services across various specialties, conducts extensive research, and offers education in clinical medicine.

NextGen Venture Partners is a venture capital firm founded in 2011 that focuses on seed and early-stage investments in technology companies across the United States. The firm operates through a broad network of venture partners and targets category-defining and industry-defining technology opportunities in a sector-agnostic approach. It typically invests in seed and early rounds, with check sizes described as ranging from hundreds of thousands to a couple million dollars, and may participate in larger rounds as needed. Headquartered in Baltimore, Maryland, with additional offices in Boston and Arlington, the firm emphasizes building partnerships with founders and accelerating growth through its expansive partner network. NextGen seeks to back ambitious companies using collaborative funding structures and strategic support to help scale globally.

Founded in 2019 and based in New York, Acronym Venture Capital is a venture capital firm that targets early-stage opportunities in enterprise software as a service, B2B sectors, and select consumer and technology-enabled businesses, including hospitality, commerce, workflow, fintech, proptech, cyber, and related areas. It typically supports late seed and Series A rounds for companies that have achieved at least one million dollars in annual recurring revenue. The firm favors first-time and diverse founders and adopts a value-add approach, using its network to help portfolio companies grow revenue, recruit talent, form partnerships, and secure follow-on capital. It operates as an opportunistic investor and avoids investments in sectors touching municipal services, utilities, schools, or hospitals.

Right Side Capital Management is a San Francisco based venture capital firm that backs early-stage technology startups with a focus on pre-seed rounds. It makes about 75-100 investments per year in capital-efficient companies seeking to reach product-market fit, typically in rounds of 50k to 500k and pre-money valuations of 1M to 3M. The firm pursues opportunities outside the San Francisco Bay Area and New York City, and it invests across the United States, Canada, Israel, Australia, New Zealand, and Western Europe, with a portfolio spanning many states and roughly two hundred prior investments since its early operations.

Advantage Capital Partners is a United States‑based venture capital firm that provides growth equity, debt, and mezzanine financing to small and mid‑market companies, with a focus on underserved communities and state and local economic development. The firm invests across sectors including manufacturing, technology, business services, life sciences, and energy, and also supports real estate development projects with equity and debt. It typically makes initial investments ranging roughly from half a million to ten million in companies with modest sales, and may participate in larger follow‑on rounds or co‑invest with other firms. It uses senior debt, mezzanine debt, subordinated loans, and government‑guaranteed lending, and often pursues equity positions through preferred shares or convertible notes. Advantage Capital operates nationwide in the United States, with roots in New Orleans and offices in multiple states, and has backed thousands of jobs and housing projects as part of its mission to expand inclusive economic growth.