PrairieGold Venture Partners is an early-stage venture capital firm based in Sioux Falls, South Dakota. It focuses on investments in life sciences and green technology, with activity spanning information technology and alternative energy. The firm pursues Midwest opportunities and typically supports portfolio companies with strategic guidance, including board representation. It emphasizes collaborative, long-term partnerships and leverages expertise in project finance and market knowledge to back innovative startups and emerging companies across North America.

Khosla Ventures is a venture capital firm based in Menlo Park, California, that funds and supports technology companies across stages and sectors, including artificial intelligence, healthcare, climate tech, digital health, and consumer technology. It provides capital and strategic guidance to help startups develop innovative products, scale operations, and build enduring businesses, with an emphasis on science-driven, high-impact ventures and unconventional ideas. Founded by Vinod Khosla, the firm seeks to back companies addressing large, underserved markets and to contribute hands-on support beyond funding.

Alumni Ventures is a venture capital firm that broadens access to venture and private market investments for accredited investors, including alumni networks, by enabling co-investment alongside leading VC firms. It offers investment funds, investing clubs, portfolio opportunities, and educational resources through its AV Academy, and provides support to startup founders. The firm emphasizes transparency with access to due diligence materials and live discussions, and seeks to build a diversified portfolio through collaborative investing. Headquartered in Manchester, New Hampshire, it operates with offices in New York, Boston, Menlo Park, Chicago, London and Tokyo to reach a broad investor base.

Drumbeat Ventures is a venture investment firm founded in 2020 and based in Sioux Falls, South Dakota. It focuses on early-stage investments in emerging brands across edtech, technology and consumer sectors, typically deploying about 1-5 million dollars. The firm emphasizes a culture-driven approach, aiming to help founders build positive organizational cultures that support strong performance and significant returns. Led by Adam Burgoon, Drumbeat Ventures leverages over 25 years of growth investing experience and an advanced degree in Applied Positive Psychology from the University of Pennsylvania to assess culture and unlock human potential. It operates at angel and institutional investment levels, offering strategic oversight and support to identify breakout brands and nurture them toward growth.

Homegrown Capital is a venture capital firm headquartered in Brookings, South Dakota, focusing on early-stage technology companies in the Midwest and Northern Plains. It targets seed to Series A rounds in sectors such as B2B software, agricultural technology, finance technology, and related areas, with typical investments ranging from about 0.5 to 2 million. The firm takes active board roles to provide strategic guidance and leverage its network, aiming for exits in roughly five to seven years. Its regional emphasis covers the Midwest and Northern Plains, while remaining open to opportunities beyond, and it draws on extensive deal experience including more than a hundred transactions through a network of angel funds to support scalable, high-potential ventures.

Founders Fund is a San Francisco-based venture capital firm that provides funding across all stages to science and technology companies pursuing transformative innovations. The firm backs startups addressing complex problems in areas such as aerospace, artificial intelligence, energy, health, cybersecurity, data analytics, and software, and has supported notable portfolio companies including SpaceX, Palantir, Facebook and Airbnb. Founders Fund emphasizes a founder-friendly approach that aims to offer substantial support with minimal interference, while potentially deploying capital globally as needed. The firm seeks to invest in companies with the potential to reshape industries and the future through advanced engineering, manufacturing, and information technology.

RA Capital Management is a Boston-based investment firm focused on healthcare, life sciences, and planetary health. The firm pursues evidence-based investing across public and private markets and provides hands-on support to portfolio companies, including through its Raven healthcare incubator. It relies on deep research via its TechAtlas knowledge engine to identify opportunities and guide value creation from early-stage ideas to commercialization. Since its inception, the firm has deployed capital across multiple rounds and has built a portfolio of hundreds of companies, backed by an ongoing effort to advance drugs, medical devices, diagnostics, and biotech tools. RA Capital manages substantial assets and seeks to invest across stages—from seed to growth—often taking leading roles or co-investing and participating in governance to support management teams. The firm emphasizes impact in healthcare and planetary health, aiming to translate bold ideas into durable improvements in patient care and public health.

Commodore Capital is a New York-based venture capital firm focused on biopharmaceuticals. Founded in 2019, the firm concentrates on early-stage companies developing innovative therapies, with emphasis on genetic medicines and cellular therapies, during a period of rapid scientific advancement translating into clinical breakthroughs. It aims to be a supportive partner to smaller biopharmaceutical companies as they develop and deliver new medicines to patients globally.

Vivo Capital is a global healthcare investment firm founded in 1996 and headquartered in Palo Alto, California, with offices in Asia. It operates a multi-strategy platform that encompasses growth equity, private equity including buyouts, venture capital, and public equity, and it has invested in over 290 public and private companies. The firm supports a broad range of healthcare sectors, including biotechnology, pharmaceuticals, medical devices, and healthcare services, with a focus on the largest healthcare markets. Its multidisciplinary team includes physicians, scientists, entrepreneurs, operating executives, and industry experts, who collaborate across strategies to build high-quality companies in the United States and China.

Initialized Capital is a San Francisco-based early-stage venture capital firm focused on seed investments, supporting founders building innovative technology companies across sectors such as software as a service, sustainability, health, AI, and crypto with long-term mentorship and guidance from early-stage to growth stages.

RiverPark Ventures is a New York-based early-stage venture capital firm that backs high-growth, disruptive companies across sectors such as enterprise technology and evolving consumer behavior. The firm emphasizes an operator-driven approach, leveraging the experience and networks of seasoned investment professionals to support portfolio companies through the business lifecycle. It writes modest first checks and larger growth investments to fuel product development and market expansion, prioritizing teams with compelling leadership, clear customer needs, and recurring revenue. By focusing on transformative business models and strategic guidance, RiverPark Ventures aims to accelerate value creation for its portfolio.

Off The Grid Ventures is a San Francisco-based venture capital firm founded in 2016 that focuses on supporting women-led and foreign/immigrant-founded companies in information technology, SaaS and fintech, with emphasis on B2B technology and financial technology sectors.

GGV Capital is a global venture capital firm that reorganized in March 2024 into two distinct brands: Granite Asia and Notable Capital. Granite Asia, headquartered in Singapore, targets investments across the Asia-Pacific region, including Southeast Asia, Japan, China, India, and Australia. Notable Capital, based in Silicon Valley with offices in San Francisco and New York, pursues opportunities in the United States, Israel, Europe, and Latin America. The firm supports founders with resources and a community through events and podcasts, and has invested in notable companies such as Streamlit, HashiCorp, Grab, Affirm, Poshmark, Wish, and Airbnb.

Notable Capital is a United States–based venture capital firm that targets early- to growth-stage investments in cloud infrastructure and business and consumer applications. It operates across the United States, Israel, Europe, and Latin America, pursuing select opportunities to help founders scale globally. The firm provides capital and strategic guidance to portfolio companies, focusing on long-term growth, operational support, and international expansion. Notable Capital's investments span sectors such as artificial intelligence, cybersecurity, and software, and its portfolio includes names like Affirm, Airbnb, Slack, HashiCorp, Vercel, and Zendesk, among others.

Transpose Platform is an early-stage venture platform based in San Francisco that backs frontier founders and provides hands-on support to accelerate growth. Rather than focusing solely on capital, it positions itself as a partner from the outset, pursuing strategic guidance, operational feedback, and long-term collaboration to help portfolio companies define new categories. The platform leverages a broad network of limited partners and strong connections within the venture ecosystem to access diverse investment opportunities and resources. It pursues a proactive, relationship-driven approach, cultivating category-defining companies by nurturing promising ideas from inception rather than chasing prevailing trends. Transpose Platform also hosts short, intensive events in multiple global locations to identify promising startups at their earliest stages. Ethereum is cited as a trusted advisor, reflecting the platform’s deep network and strategic involvement. The emphasis is on building enduring relationships with founders and LPs and providing ongoing support throughout a company’s lifecycle.

Sound Ventures is a Beverly Hills-based venture capital firm that invests in early- and mid-stage technology companies. It operates as a registered investment adviser and emphasizes investments at the intersection of technology, culture, media, and influence.

Forerunner Ventures is a San Francisco-based venture capital firm that focuses on consumer-oriented and technology-enabled businesses, aiming to understand the modern consumer and support founders with funding, strategic guidance, and consumer insight to help build category-defining brands. The firm typically invests in seed and Series A rounds, often prioritizing opportunities in the Bay Area but considering investments in New York and Los Angeles, and it collaborates with portfolio companies to accelerate growth; notable investments include Dollar Shave Club, Warby Parker, and Hims & Hers.

Boston-based venture capital firm focusing on expansion-stage investments in technology companies, including software as a service and cloud-based software, and it supports portfolio companies post-investment through its Expansion Platform to help with hiring, customer acquisition and partnerships, driving growth and market leadership. Founded in 2006, OpenView emphasizes tailored guidance from experienced partners to help founders scale.

Greenspring Associates is a United States-based fund-of-funds investment firm, founded in 2000 and headquartered in Owings Mills, Maryland. It provides financial and investment advisory services and manages commingled funds and customized partnerships for a global client base, including institutions and individuals across North America, Europe, Asia, the Middle East, and Australia. The firm focuses on venture capital, investing in established and emerging fund managers as well as secondary venture capital investments, and it supports opportunities across early and growth stages of venture-backed companies. In 2021, Greenspring Associates was acquired by StepStone Group.

Western Technology Investment is a venture debt firm based in Portola Valley, California, founded in 1980. It provides debt financing and related capital solutions to technology and life sciences companies, often combining debt with equity via warrants when appropriate. The firm targets revenue-generating early- to growth-stage businesses, offering flexible, founder-friendly credit facilities designed to minimize equity dilution and preserve operational freedom. Typical loan sizes span from hundreds of thousands to tens of millions of dollars, with structures tailored to support rapid growth across stages, from seed to public listing. WTI conducts venture lending across North America and has a long track record of backing numerous technology and life science companies, aiming to accompany ventures through all phases of their journey.

Kleiner Perkins Caufield & Byers is a U.S.-based venture capital firm founded in 1972 by Eugene Kleiner and Tom Perkins. The firm specializes in seed, early-stage, and incubation investments and partners with founders from inception to IPO and beyond, supporting growth across multiple industries. Its investments span digital technologies, information technologies, life sciences, and healthcare, with a history of backing notable portfolio companies such as Google, Amazon, Citrix, and Netscape. Kleiner Perkins emphasizes strategic guidance and operational support to help portfolio companies scale, including talent, business development, and product development resources. The firm maintains a broad geographic reach, investing in the United States, Canada, Europe, and China, and has launched dedicated initiatives and funds to back greentech, data, and other technology innovations.

Breakthrough Energy Ventures is an investor-led venture fund composed of members of the Breakthrough Energy Coalition, based in Kirkland, Washington. The fund takes a patient approach to investing in clean energy and environmental technologies, aiming to deliver reliable and affordable power while not warming the planet. It supports technologies across the energy value chain with potential to decarbonize power generation, storage, transportation, manufacturing, and buildings, prioritizing scalable solutions that address climate change and energy access. By leveraging the coalition’s scientific and technological expertise and global network of researchers and entrepreneurs, Breakthrough Energy Ventures seeks to back companies with the potential to transform energy systems and accelerate deployment of breakthrough innovations.

Primary Venture Partners is a seed and early-stage venture capital firm based in New York that backs technology companies across sectors including software, IT, enterprise SaaS, mobile, commerce, manufacturing, and energy. The firm pursues a hands-on, high-conviction approach, deploying a large operating team and a broad expert network to help founders hire, win customers, and raise future rounds. It runs a Talent Program and provides financial advisory, market development, and other support to help portfolio companies scale from seed toward Series A and beyond, with a NYC-focused origin and global reach. The firm emphasizes active involvement from seasoned operators to accelerate growth and turn ideas into scalable businesses.

HPS Investment Partners is a global investment firm specializing in non-investment grade and private credit. Founded in 2007 and headquartered in New York, the firm maintains a multinational footprint with offices around the world and serves institutional clients such as pension funds, insurers, endowments, sovereign wealth funds, and financial advisors. Originating as a unit of Highbridge Capital Management, the firm was acquired by its principals and has grown to provide tailored credit solutions across direct lending, asset-based finance, and liquid credit, emphasizing risk management and long-term partnerships.

Vesta Ventures is a venture capital investment firm founded in 2021 and based in Reno, Nevada, focused on funding companies operating in the residential property technology sector.

Forge Global is a private securities marketplace and platform that provides marketplace infrastructure, data, and technology to participants in the private market. It enables investors, shareholders, companies, and institutions to access, buy, and sell shares of pre-IPO companies, facilitating liquidity in the private markets. The platform offers proprietary data and price insights, including Forge Price, a daily indicative price for selected pre-IPO companies, along with private market indices to inform investment decisions. It supports employees selling their share ownership and provides custody services to help navigate private market transactions. Forge Global serves a broad range of clients, including individual, accredited, institutional, and corporate investors, by delivering data solutions, trading capabilities, and educational resources related to private company investments and IPO pipelines.

Kli Capital is an operator-led venture capital firm that backs early-stage startups in Pre-Seed and Seed rounds. It emphasizes a founder-centric approach and leverages its operational experience to support entrepreneurs through growth, focusing on meaningful problem solving across sectors such as healthcare, fintech, consumer, enterprise software, logistics, retail technology, and building products. Since its inception in 2015, the firm has completed more than 90 investments, with a portfolio of active companies and a track record including exits, and maintains a diversified geographic footprint across the United States and Israel.

Goodwater Capital is a venture capital firm based in Burlingame, California, established in 2014. It concentrates on consumer and prosumer technology, investing across multiple stages with a founder-first, data-driven approach. The firm seeks to empower exceptional entrepreneurs to create positive change globally and supports portfolio companies through research insights and founder-focused resources. It backs a wide range of consumer technologies and services that aim to improve everyday life, bridging sectors such as housing, financial services, healthcare, and entertainment. The practice emphasizes helping founders scale by combining market insight with hands-on support.

Eclipse Ventures is a Palo Alto-based venture capital firm that backs early-stage companies in the United States across consumer goods, healthcare, industrials, and technology, with a focus on the physical economy. Since its founding in 2015, the firm leverages operating experience from building factories and shipping hardware to scaling supply chains and navigating policy and regulatory complexity to help portfolio companies reach customers and critical milestones. Eclipse seeks to power the Industrial Evolution by supporting entrepreneurs who make physical industries more efficient, resilient, and profitable, pairing capital with strategic guidance, technology validation, leadership recruitment, and go-to-market support.

Adapt Ventures is a venture capital firm founded in 2020 and based in Miami, Florida. It invests in fintech, software, consumer, and healthcare companies and backs audacious founders with bold visions. The firm focuses on early-stage opportunities across sectors and provides capital along with strategic guidance and operational support to portfolio companies.

Trust Ventures is a venture capital firm based in Austin, Texas, established in 2018. It provides capital and strategic advisory to technology-focused portfolio companies, helping them navigate public policy barriers and regulatory hurdles. The firm develops advocacy strategies and builds relationships to support portfolio companies in entering and competing in markets, with a focus on enabling growth and innovation through policy-aware governance and regulatory navigation.

Bling Capital is a venture capital firm founded in 2018 and based in the San Francisco Bay Area, California. It invests in seed, early, and growth-stage technology companies across consumer tech, internet and mobile, marketplaces, data, fintech, SaaS, and automation, supporting product development and scaling for product-led businesses.

Southern Israel Bridging Fund is a venture capital firm based in Beer Sheva, Israel, with an additional office in Melbourne, and was founded in 2018. The firm provides growth capital and strategic guidance to early- and growth-stage technology companies across sectors including agri-tech, enterprise software, medical devices, cyber, mobile and new media, health-tech, bio-tech, energy and artificial intelligence. It typically invests between 0.05 million and 5 million dollars and aims to exit investments within 6 to 48 months, averaging around 24 months. Beyond capital, the firm offers hands-on support in business model development, go-to-market strategy and operational improvements, fostering partnerships and helping portfolio companies pursue exits through IPOs or acquisitions. The firm emphasizes bridging the death valley between seed and Series A by leveraging its network and domain expertise to accelerate growth.

OurCrowd is an Israel-headquartered venture investing platform that provides access to private market opportunities, including startups and venture funds, to accredited investors and institutions. Founded in 2013, it vets and selects opportunities, conducts due diligence, and supplies market insights to help users build diversified portfolios. The platform enables direct investments and co-investments, offers mentorship and introductions to industry advisors, and supports portfolio companies throughout their lifecycle, including follow-on rounds and growth connections. With a global network and offices in Jerusalem and other regions, it enables cross-border participation across Israel, the United States, Asia-Pacific, and beyond. It focuses on curated opportunities across technology-enabled sectors and supports informed investment decisions through resources, education, and performance tracking.

CNF Investments is a private investment firm focused on venture capital and private equity opportunities, managing over $350 million in capital with investments in technology, healthcare, and energy. It considers direct and fund investments and acts as an active investor, partnering with experienced entrepreneurs and co-investors to build companies. The firm emphasizes growth-stage opportunities while remaining open to early and late-stage ventures, and conducts thorough due diligence with a focus on management teams and other key players. Its approach centers on the right mix of people, experience, hard work, focus, and execution. CNF Investments is affiliated with Clark Enterprises.

Gamma Biosciences specializes in life sciences, focusing on bioprocessing tools and technologies for the development and production of advanced therapies such as vaccines, biologics, cell, and gene therapies.

Oak HC/FT is a Stamford, Connecticut-based venture and growth equity investment firm focused on healthcare information services and financial services technology. Founded in 2014, it backs healthcare and fintech companies across the United States from seed to growth stages, providing strategic counsel, board-level participation, and access to an extensive industry network to help portfolio companies scale, with an emphasis on technology and AI-enabled solutions.

Merck & Co. is a global biopharmaceutical company focused on discovering, developing, and delivering medicines and vaccines to improve human health. The company emphasizes a research-intensive approach across therapeutic areas such as oncology and immunology, including personalized neoantigen therapies, and maintains a broad portfolio of vaccines, with immuno-oncology products like Keytruda driving significant sales. Merck also supports patient access through assistance programs and pursues sustainability and social responsibility initiatives, including programs to advance maternal health. With a substantial global footprint, the company advances its pipeline through clinical trials and emphasizes responsible manufacturing and global operations.

Teamworthy Group is a venture capital firm based in Greenwich, Connecticut, that makes seed, early and growth-stage investments in technology companies. It targets marketplaces and e-commerce, SMB SaaS, information services, edtech, fintech, sports tech, developer tools and APIs, marketing tech and adtech, imaging and sensor networks, health IT and travel tech. The firm seeks long-term partnerships with entrepreneurs, leveraging its network of founders and partners to support portfolio companies with introductions to customers, partners and talent.

The Startup Factory is an accelerator based in Durham, North Carolina, founded in 2012 that supports early-stage startups by providing seed capital and a structured three-month program. In exchange for 7.5% equity, participating companies receive $50,000 in seed funding, mentorship, and access to a network of angels, veteran founders, and technology experts; upon successful completion, the program may offer additional funding through convertible notes ranging from $20,000 to $150,000. The accelerator targets startups operating in web, mobile, software, tourism, hospitality, and education sectors.

UnitedHealth Group is a diversified healthcare company in the United States that operates through two main platforms, UnitedHealthcare and Optum, with OptumHealth, OptumInsight, and OptumRx as principal components. It offers health insurance plans and related services, as well as a broad range of health services including care delivery, software and information solutions, analytics, and pharmacy care. The company serves individuals, employers, and government programs through a combination of consumer and provider payment systems, network-based services, and data-driven care management designed to improve access, affordability, and health outcomes. UnitedHealth Group leverages clinical data and technology to redesign and automate administrative processes, enhance decision-making, and support its provider and payer ecosystems. With global reach and large scale, the group aims to drive value across its healthcare delivery and benefits businesses, partnering with providers, communities, and policymakers to extend access and improve care.

FJ Labs is a New York-based venture capital firm founded in 2015 by Fabrice Grinda. It is stage-agnostic and focuses on marketplaces and consumer-facing startups, with seed and Series A investments. The typical investment range is $50,000 to $5,000,000. The firm backs entrepreneurs pursuing network effects and transformative business models, and its portfolio includes notable companies such as Alibaba Group, Beepi, BrightRoll, Betterment, Adore Me, and Earnest.

Foundation Capital is a United States-based venture capital firm founded in 1995 and headquartered in Palo Alto, California. The firm partners with entrepreneurs from idea to scalable businesses, offering hands-on support from a team of former founders and operating executives. It invests across sectors including enterprise software, data platforms, cybersecurity, fintech, consumer technology, and digital energy, often taking leading roles and board seats in portfolio companies. The firm has backed more than 60 high-growth ventures and has a track record of IPOs and acquisitions, with notable investments in Lending Club, Netflix, Sunrun and other technology leaders.

CSC Upshot Ventures is a Palo Alto-based venture capital firm founded in 2015 that focuses on seed and early-stage technology investments. It targets enterprise software, artificial intelligence, healthcare, fintech, and marketplaces, with an international investment footprint spanning the United States, Canada, Europe, South America, and South Africa. The firm emphasizes a founder- and operator-led approach developed in partnership with AngelList to support startup communities and help early-stage companies scale.

BoxGroup is a New York-based venture capital firm that backs early-stage technology startups, typically from pre-seed to Series A, across sectors such as consumer, enterprise software, fintech, healthcare, life sciences, climate, and marketplaces. The firm seeks founders with strong teams and ambitious visions, supporting movements in existing markets or the creation of new ones, and it is known for hands-on involvement with portfolio companies. While its reach is national and international, BoxGroup maintains a strong presence in New York City and engages with ecosystems in Silicon Valley and Los Angeles. Founded in 2009 by David Tisch, BoxGroup has built a track record of backing promising startups at formative stages and operates through several funds and vehicles to support early-stage companies.

Index Ventures is a venture capital firm headquartered in London, with operations in San Francisco and Geneva, that funds and supports technology-driven companies across stages from seed to growth. It collaborates with entrepreneurial teams to assess business models, help scale operations, and navigate development and market-entry challenges. The firm provides capital, due diligence, deal structuring, and ongoing strategic guidance to portfolio companies, leveraging a global network of industry relationships to connect founders with customers, partners, and opportunities.

Amity Ventures is a San Francisco-based venture capital firm that backs early-stage technology companies. The firm emphasizes a people-centered approach, supporting founders in building category-defining businesses, and actively engages with portfolio companies through board participation and hands-on guidance. It has invested in more than fifty companies across information technology, mobile, cryptocurrency and blockchain, and areas enabled by AI, including healthcare, fintech, logistics and autonomous systems. The firm typically participates in rounds ranging from pre-seed to Series A, often leading or co-leading investments in rounds of roughly $1–5 million. Amity Ventures focuses on long-term partnerships with founders to support fundraising and strategic decisions.

ARCH Venture Partners is a Chicago-based venture capital firm with offices in Seattle that concentrates on life sciences and science-driven startups. Founded in 1986, it partners with scientists and entrepreneurs to bring innovations to market by providing capital, strategic guidance, and access to networks across the company’s lifecycle. The firm emphasizes translational work from academic research and national laboratories, and has raised more than $3 billion across multiple funds and invested in more than 150 companies, highlighting a hands-on approach to catalyzing discovery and execution in the life sciences sector.

Right Side Capital Management is a San Francisco-based venture capital firm that backs early-stage, capital-efficient technology companies in the United States and Canada. It employs a quantitative, data-driven approach to identify opportunities, enabling fast, transparent funding decisions. The firm typically writes small checks in the range of 50,000 to 500,000 and provides founders with mentorship, operational guidance, and access to later-stage investors. Focusing on startups outside major hubs, it emphasizes revenue-generating models with scalable potential and aims to build a diversified portfolio while delivering practical post-investment support.

Andreessen Horowitz is a venture capital firm founded in 2009 and based in Menlo Park, California. It provides capital across development stages from seed to late-stage growth and invests in software and technology companies across artificial intelligence, biotech and health, consumer technologies, cryptocurrency, fintech, enterprise software, infrastructure, and related sectors. Beyond funding, the firm offers operational support through a structured ecosystem of technical advisors, executive talent, and industry operators, and differentiates itself with strategic guidance, thought leadership, and programs to nurture talent. It maintains a global presence and supports portfolio companies with resources and networks to accelerate growth.