The Southern Appalachian Fund is a $12.5 million venture capital firm based in Oak Ridge, Tennessee, with an additional office in London, Kentucky. It invests in early and expansion-stage companies operating in the interactive home entertainment, manufacturing, technology, and software sectors, with a focus on small businesses in southern Appalachia, particularly in Kentucky, Tennessee, and the Appalachian counties of Georgia, Alabama, and Mississippi. The fund typically invests between $200,000 and $600,000 in its portfolio companies, often leading investment syndicates or co-investing with other institutional investors and seasoned angel investors. It seeks to generate market-rate returns for its investors while promoting shared and sustainable business growth and wealth creation in its target region. The fund's mission is to provide not only equity capital but also operational assistance, active board participation, and mentoring to its portfolio companies.

Advantage Capital Partners is a United States‑based venture capital firm that provides growth equity, debt, and mezzanine financing to small and mid‑market companies, with a focus on underserved communities and state and local economic development. The firm invests across sectors including manufacturing, technology, business services, life sciences, and energy, and also supports real estate development projects with equity and debt. It typically makes initial investments ranging roughly from half a million to ten million in companies with modest sales, and may participate in larger follow‑on rounds or co‑invest with other firms. It uses senior debt, mezzanine debt, subordinated loans, and government‑guaranteed lending, and often pursues equity positions through preferred shares or convertible notes. Advantage Capital operates nationwide in the United States, with roots in New Orleans and offices in multiple states, and has backed thousands of jobs and housing projects as part of its mission to expand inclusive economic growth.

Triangle Tweener Fund, established in 2021 and based in Raleigh, North Carolina, is a venture capital firm focused on investing in early-stage, high-technology startups within the Triangle area, which includes Raleigh, Durham, and surrounding regions. The firm aims to build a comprehensive index of private company investments that meet its specific 'Tweener List' criteria, targeting promising ventures at a critical stage of their development. By concentrating on seed and early-stage investments, Triangle Tweener Fund seeks to support the growth of innovative companies that have the potential to contribute significantly to the local economy and the tech landscape.

Founded in 1987, Canaan Partners is a global venture capital firm based in Menlo Park, California. With over $5 billion under management, the firm invests in early-stage technology and healthcare companies worldwide.

Braemar Energy Ventures is a New York–based venture capital firm that focuses exclusively on technology and communications opportunities in the energy sector. Founded in the early 2000s by four principals with deep investment, financing, and operating experience in energy, the firm targets early‑stage companies across energy technology, mobility, power, resource revolution, and infrastructure. It helps portfolio companies mature by providing strategic guidance and financing expertise, leveraging industry knowledge to address long‑term challenges and enable management teams to focus on execution and growth as they integrate into the broader energy market.

Khosla Ventures is a California-based venture capital firm founded in 2004 by Vinod Khosla. It provides capital and strategic guidance to startups across stages, focusing on technology-driven companies in areas such as artificial intelligence, climate and sustainability, enterprise software and services, fintech, digital health, medical technology and diagnostics, therapeutics, consumer products, and frontier technologies. The firm backs bold ventures with the potential to disrupt markets and improve lives, supporting companies from early to growth stages and working closely with entrepreneurs to apply science, technology and innovative business models. While primarily investing in North American technology companies, Khosla Ventures pursues opportunities globally and emphasizes experimentation and impact alongside financial returns. The firm also maintains related impact initiatives that support entrepreneurs addressing socio-economic challenges in emerging markets.

PJC, established in 2001, is a Boston-based venture capital firm. It invests in early-stage companies across North America, focusing on entrepreneurs driving innovation. With over 100 investments, notable portfolio companies include Expensify, Nest, and BlockFi. PJC is a Registered Investment Adviser.

Founded in 1997 and headquartered in Boston, Egan-Managed Capital is a venture capital firm focusing on seed to early-stage investments in information technology and SaaS companies based in the New England region. The firm invests $0.5 million to $5 million per company, typically in convertible preferred stocks, often co-investing with other firms and seeking board representation.

Founded in 2002, Borealis Ventures is a venture capital firm based in Hanover, New Hampshire. It specializes in seed and early-stage investments, focusing on life sciences, healthcare, digital health, information technology, and design & engineering software companies. The firm prefers to be the lead investor and seeks board seats in its portfolio companies.

Charge Ventures is a venture capital firm founded in 2015 and based in Brooklyn, New York. The firm focuses on seed and early-stage investments in a variety of sectors, including artificial intelligence, machine learning, augmented reality, virtual reality, blockchain, mobile applications, marketplaces, logistics, software as a service, direct-to-consumer healthcare, and the future of work. While it invests across the United States, Charge Ventures has a particular emphasis on opportunities in New York City and other major metropolitan areas such as Chicago, Atlanta, Boston, San Diego, and Miami.

SemperVirens Venture Capital is an early-stage venture capital investment firm founded in 2018 and based in San Mateo, California. The firm focuses on investing in companies within the workforce technology, healthcare technology, and financial technology sectors, aiming to address the needs of employers. SemperVirens is recognized for its team's deep industry experience, strong relationships, and valuable insights, which support its investment strategy and foster the growth of innovative companies in these domains. As a Registered Investment Adviser, SemperVirens is committed to guiding its portfolio companies toward success in a rapidly evolving market.

Goodwater Capital is a California-based venture capital firm founded in 2014 that targets early-stage investments in consumer technology and related sectors, including housing, financial services, consumer products and services, healthcare, food, transportation, education, and entertainment. It backs exceptional entrepreneurs who create products and platforms that consumers love, with a focus on solving pressing problems and shaping the culture and global economy. Through its investments, Goodwater aims to enable startups capable of delivering broad, measurable improvements in billions of lives, reflecting a commitment to long-term positive impact.

Lightspeed Venture Partners is a global venture capital firm based in Menlo Park that funds early-stage and growth-stage companies across consumer, enterprise technology, fintech, cleantech, healthtech, and software sectors. The firm backs startups from seed through expansion rounds, providing capital and strategic guidance to help entrepreneurs scale. It operates internationally with offices in the United States, China, India, and Israel, and has a history of investing in software, mobile, data, internet, and technology-enabled services. Lightspeed emphasizes identifying emerging trends, supporting talented teams, and pursuing opportunities in areas such as enterprise infrastructure, digital platforms, and consumer technologies. The firm seeks to partner with ambitious founders to accelerate product development, go-to-market execution, and global growth.

Rosewood Private Investments is a Dallas, Texas-based private equity and venture capital firm and family office that manages diverse investment activities globally. The firm emphasizes conservative capital structures to enable prudent reinvestment of profits for development and aims to back companies across multiple sectors, primarily in the United States. It invests in industries including industrial and commercial services, nutrition and wellness, environmental services, business services and technologies, consumer products, manufacturing technologies, specialty materials, and residential services.

Founded in 2000, General Catalyst is a venture capital firm specializing in early-stage and growth equity investments. It focuses on accelerating ideas, careers, and companies towards success by providing ongoing momentum and mentorship based on deep experience.

Network Ventures is a Chicago-based venture capital firm founded in 2016 that focuses on providing funding to seed stage companies. The firm primarily invests in businesses within the internet and technology sectors, aiming to support early-stage companies as they develop and grow. By concentrating on these industries, Network Ventures seeks to foster innovation and facilitate the success of emerging entrepreneurs.

Founded in 2009, Block is a technology company specializing in financial services. It offers payment services to merchants and operates Cash App, a person-to-person payment network.

GrowthX is a San Francisco-based private equity and venture capital firm founded in 2015 that targets seed-stage technology companies and makes seed-stage investments, with an emphasis on business-to-business software and other technology ventures, supporting B2B founders across North America.

Founded in 2010, TSVC is a venture capital firm headquartered in Los Altos, California. It specializes in early-stage investments in deep technology startups across sectors such as software as a service, artificial intelligence, financial technology, biotechnology, blockchain, and semiconductors.

Globespan Capital Partners is a Boston-based venture capital firm founded in 2003 that makes early-stage investments in technology-focused companies worldwide, with emphasis on information technology infrastructure, software, SaaS, mobile, and internet sectors such as e-commerce. The firm partners with entrepreneurs to build scalable infrastructure and leverages market-facing expertise and extensive industry networks to help portfolio companies realize their potential.

Advanced Technology Ventures is an American venture capital firm founded in 1979, with offices on both coasts in Boston, Massachusetts and Menlo Park, California. The firm focuses on early- to growth-stage investments across sectors including information technology, software and services, communications, infrastructure, consumer technology, biopharmaceuticals, medical devices, cleantech, digital health, and life sciences. ATV backs companies across business-to-business software, healthcare IT, and other technology-enabled markets, emphasizing innovative technologies and scalable business models. Since its inception, the firm has managed multiple investment funds and completed hundreds of investments, exiting a significant portion as companies mature. ATV operates as an active investor, providing strategic guidance and capital to support growth from initial rounds through later stages.

Founded in 2012, The Startup Factory is an early-stage venture fund based in Durham, North Carolina. It invests seed capital in exchange for equity, providing mentorship, coaching, and access to a network of active angels and experienced founders through its three-month accelerator program.

Richland Ventures was a venture capital firm founded in Nashville, Tennessee in 1994. It specialized in providing expansion capital to healthcare service companies, medical devices, technology, and other diversified service companies across the Southeast, Midwest, and Southwest United States.

Clayton Associates is a Nashville-based family office that makes seed to early-stage investments in healthcare and technology companies in the United States. Founded in 1996, it concentrates on healthcare technology, digital health, information technology, software, and technology-enabled services, and favors opportunities in the Southeast and Southwest United States. The firm typically makes equity investments ranging from about 0.5 million to 6 million, with enterprise values of 3 million to 15 million, and can participate in seed rounds of up to 0.5 million. It seeks minority stakes of roughly 20% to 40% and also engages in angel investments. Clayton Associates works through affiliates and partnerships, including Bullpen Ventures and Rolling Hills Ventures, via its venture-capital manager FCA Venture Partners. The firm is based in Brentwood and Nashville, Tennessee, with a history of supporting entrepreneurs and building growth in the healthcare and technology sectors.

Founded in 2009, TriStar Health Partners is a venture capital firm specializing in early-stage investments, primarily focusing on healthcare innovation. It invests in life sciences, diagnostics, medical devices and technologies, IT, and healthcare services companies, with a preference for those based in the Southeast United States, particularly Tennessee.

Founded in 2001, VentureTech Alliance is a venture capital firm based in San Jose, California. It specializes in investing in the semiconductor industry and other emerging technology areas.

Tribeca Early Stage Partners is a New York-based network of financial professionals that specializes in financing, advising, and supporting early-stage FinTech companies. Established in 2014, the organization operates as a FinTech-focused venture group and has built a community of approximately 50 accredited investors. This network comprises entrepreneurs and business leaders with extensive expertise in institutional finance and technology, enabling them to provide valuable insights across various sectors, including fintech, data, insure-tech, proptech, deep tech, and science. Through their collective experience, Tribeca Early Stage Partners aims to foster innovation and growth in the evolving landscape of financial technology.

Founded in 2005, Sageview Capital is a private equity and venture capital firm specializing in growth equity investments. It focuses on tech-enabled businesses across financial services, business services, and technology sectors, typically investing between $15 million to $100 million in companies with revenues ranging from $10 million to $50 million. Based in Greenwich, Connecticut, with additional offices in Palo Alto, California, the firm seeks majority or minority stakes and aims to hold investments for three to seven years.

Dobbs Equity Partners LLC is a private equity and venture capital firm based in Memphis, Tennessee, with an additional office in Dallas, Texas. The firm specializes in growth capital, management buyouts, distressed sales, and turnarounds within start-ups and middle-market companies. It focuses on investing in sectors such as distribution, industrial services, healthcare, manufacturing, and business franchises, while avoiding real estate, speculative technology, and biotech ventures. Dobbs Equity Partners typically invests between $3 million and $25 million in companies with enterprise values ranging from $5 million to $40 million and EBITDA exceeding $3 million. As a family-owned entity, it employs its own capital for investments and does not seek external funding, allowing for long-term, flexible investment horizons. The firm prioritizes partnering with experienced operators, providing support in back-office functions while refraining from managing daily operations.

Great North Ventures is a venture capital firm based in Maple Grove, Minnesota, founded in 2017. The firm focuses on investing in entrepreneurs who leverage breakthrough technologies to transform industries that remain reliant on analog processes. Great North Ventures primarily targets disruptive technology companies across the United States, providing essential guidance, capital, and connections from seed stage to Series B. The firm is committed to identifying promising startups regardless of their geographic location, recognizing that innovative companies are emerging beyond traditional hubs like Silicon Valley. With a foundation built by successful founders, Great North Ventures emphasizes the importance of execution and the capability of their portfolio companies.

New Stack Ventures is an early-stage venture capital firm based in Chicago, founded in 2015. It focuses on pre-seed and seed investments, typically backing rounds from approximately $300,000 to $2 million. The firm seeks opportunities across sectors including business-to-business software, fintech, healthcare, ecommerce, legacy industrials, manufacturing, construction, and logistics.

M25 is a Chicago-based venture capital firm established in 2015 by Victor Gutwein and Mike Asem, focused on funding pre-seed and seed-stage technology startups in the Midwest. The firm supports portfolio companies across multiple industries, with a regional footprint spanning 24 Midwest cities in 11 states. Since its inception, M25 has backed more than 90 early-stage tech startups, aiming to accelerate growth and strengthen the Midwest startup ecosystem.

SJF Ventures is a Durham, North Carolina-based venture capital firm focused on growth- and early-stage investments in cleantech, sustainability, and technology-enabled services across the United States. Founded in 1999, it backs companies with annual sales typically between $2 million and $30 million and enterprise value under $50 million, investing roughly $3 million to $10 million per portfolio company and up to $15 million over the life of a company. It seeks to lead or co-invest in syndicates, sometimes alongside debt with warrants, and aims to take a board seat. Portfolio companies operate in sectors such as energy efficiency, water and waste technologies, renewable energy, sustainable agriculture, health and wellness technology, education technology, and digital services leveraging software and data. The firm pursues rapid sales growth, profitability, and premium exits through strategic mergers, initial public offerings, or buyouts, with a five-year or shorter investment horizon. It maintains offices in San Francisco, New York, and Richmond, in addition to its Durham base.

First Analysis is a Chicago-based private equity and venture capital firm founded in 1981 that concentrates on early-stage investments in the United States. Its sectors include technology and software, healthcare, services, and clean-tech/chemicals. The firm supports growth by working closely with management on strategy, recruitment, sales and marketing, and corporate development, and it generally makes lead investments or participates as a syndicate partner with typical checks of 3 to 10 million. It emphasizes in-depth industry research and aims to help portfolio companies become profitable leaders in large markets. The firm operates as a registered investment adviser.

Established in 1983, Northwood Ventures is a private equity firm based in Hobe Sound, Florida. The company invests in venture capital and buyout opportunities across various sectors, including consumer goods and services, communications, manufacturing, and financial services. With a unique long-term investment horizon, experienced professionals, and an entrepreneurial approach, Northwood Ventures partners with successful management teams to generate superior returns.

Blue Equity is a private equity firm founded in 2004, headquartered in Louisville, Kentucky. It invests in diverse industries such as distribution, talent representation, hospitality, media, finance, healthcare, and real estate. The firm focuses on investments with solid developmental potential, typically ranging from $0.1 million to $50 million. Blue Equity seeks operating control and prefers majority stakes.

Haystack is a venture capital firm founded in 2013 and based in San Francisco that supports outlier founders at the earliest stages. It concentrates on early-stage software and technology companies and pursues seed-stage investments. The firm has backed a range of early-stage startups, including notable names such as DoorDash, Instacart, Figma, Hashicorp, Carta, Applied Intuition, Opendoor, Filecoin, and Ironclad.

Courtside Ventures is a New York-based venture capital firm founded in 2015 that concentrates on early-stage investments in startups operating at the crossroads of sports, technology, media, lifestyle, and gaming. The firm emphasizes partnerships with management, leveraging its industry networks and domain expertise to provide ongoing strategic support across operations, product, and growth. It targets companies in sports, lifestyle, esports, gaming, media, and related information technology and TMT sectors, and positions itself as a professional partner for founders seeking long-term value beyond capital. The firm operates as a registered investment adviser.

Sterling.VC, established in 2014 and headquartered in New York, is a venture capital firm that invests in early-stage companies, with a focus on the web3 gaming sector.

Founded in 2009 and based in New York City, BoxGroup is an early-stage investment fund focusing on pre-seed to Series A rounds. It invests globally, with a primary focus on New York City, Silicon Valley, and Los Angeles. The firm typically allocates between $50,000 and $250,000 per investment across various sectors including consumer, enterprise, fintech, healthcare, life science, marketplace, synthetic biology, and climate.

Deep Fork Capital is a San Francisco-based venture capital firm focused on seed- and early-stage technology companies in the United States, including consumer internet, digital media, consumer products, software, and IT-enabled services. It pursues investments across software, data, mobile, e-commerce, IoT, and TMT sectors, with an emphasis on consumer technology, digital media, and enterprise applications. Typical checks have ranged from a few hundred thousand to several million dollars, and the firm combines rapid, thoughtful decision-making with partner-led guidance to help portfolio companies scale. Notable early-stage investments include Algorithmia, Dataminr, Educents, Transfix, StatMuse, Boxed, DealPath, and Canopy. The firm seeks to back entrepreneurs with strategic capital and hands-on support to accelerate growth in the U.S. market.

Salem Investment Partners is a Greensboro, North Carolina-based investment firm founded in 1999 that focuses on debt and equity investments in privately held middle-market companies. The firm engages in mezzanine financing and targets sectors including business and healthcare services, light manufacturing, consumer products, and wholesale distribution. It operates under the Small Business Investment Company program licensed by the U.S. Small Business Administration, managing multiple funds to provide growth capital to mid-market firms.

Founded in 2010, Upstage Ventures is a U.S.-based venture capital firm headquartered in New York. It specializes in investing in early-stage companies operating within the consumer internet and interactive marketing sectors.

Quotidian Ventures is a New York City-based venture capital firm that backs early-stage technology startups, including pre-seed and seed-stage companies, across sectors such as digital entertainment, advertising, mobile, e-commerce, digital publishing, information technology, big data, the internet of things, and adtech. The firm prefers to invest in companies operating in New York and Latin America, aiming to support founders building scalable software-driven products that can transform traditional industries.

Energy Spectrum Capital is a Dallas-based private equity and venture capital firm focused on energy infrastructure investments in North America. It specializes in midstream energy assets such as oil and gas pipelines, storage and transportation facilities, crude and natural gas pipelines, natural gas liquids, and related infrastructure, as well as energy service and power development companies. The firm typically makes equity investments of 50 to 200 million, including follow-on rounds, and targets exits after roughly three to seven years. Founded in 1995, it concentrates on opportunities in the United States and Canada.

Meritus Ventures is a venture capital firm based in London, Kentucky. It makes equity investments in expansion-stage private companies, with a focus on rural areas of central and southern Appalachia. The firm targets opportunities in information technology, industrials, and technology, media, and telecommunications sectors, and its activity spans across Tennessee, Kentucky, Arkansas, and Appalachian counties in Ohio, West Virginia, Virginia, North Carolina, South Carolina, Georgia, Alabama, and Mississippi. It may provide operational support to portfolio companies.

Mountain Group Capital, LLC is a venture capital and private equity firm founded in 2002 and based in Nashville, Tennessee. The firm specializes in seed, early-stage, venture equity, buyouts, growth capital, and later-stage investments, primarily targeting the life sciences, animal health, and technology sectors. Within life sciences, it emphasizes MedTech, medical devices, diagnostics, nutraceuticals, and expedited drug development. In the animal health sector, the firm focuses on technologies that enhance companion animal health and agricultural practices. Mountain Group Capital also invests in disruptive technologies that feature innovative business models with manageable development risk and a swift path to market. The firm seeks investment opportunities in North America, particularly in the Southeastern United States and Tennessee, typically targeting companies with revenues between $1 million and $50 million. It generally prefers to acquire minority interests in venture capital investments while aiming for controlling interests in buyout transactions.

An Atlanta-based private equity and venture capital firm founded in 1983 that targets early to growth-stage technology and healthcare companies in the United States, with a focus on the Southeast and Georgia. It invests across seed, startup, early and late venture, emerging growth and growth capital, and seeks to take board seats in portfolio companies. The firm focuses on software, information technology, internet security, cloud services, SaaS, data analytics, fintech and payment technologies, as well as healthcare infrastructure, health IT, revenue cycle management, telemedicine and care management platforms. It generally backs companies with roughly $2 million to $20 million in revenue and invests about $6 million to $10 million per deal. Noro-Moseley prefers opportunities headquartered in Georgia and nearby states such as Florida, North Carolina, Texas and others in the Southeast and beyond. It does not invest in pure drug development opportunities.

EnCap Investments L.P., established in 1988, is a Houston, Texas-based private equity firm focused on the oil and gas industry. It specializes in seed, start-up, emerging growth, and early venture investments, typically allocating between $10 million and $350 million per deal. The firm primarily invests in upstream and midstream oil and gas companies, with a particular interest in natural gas pipelines, processing facilities, and energy infrastructure projects. EnCap also considers investments in the energy transition sector. It operates from offices in Houston and Dallas, Texas.

Oxford Bioscience Partners is a venture capital firm specializing in early-stage investments in life sciences, healthcare, and related technology sectors. It provides equity financing and strategic support to emerging companies, with particular emphasis on medical devices, R&D instruments and systems, therapeutics, and related technologies across the United States and Korea. Founded in 1992 and headquartered in Mansfield, Massachusetts, with an additional office in Seoul, the firm typically invests from seed to early rounds and often serves as lead investor and takes a board seat to help portfolio companies scale.