Morningside is a Boston-based investment firm founded in 1986 as a family office for the Chan family. It makes venture capital investments in companies with novel science and technology, with deep expertise in life sciences, digital health, artificial intelligence, materials, and technology. The firm takes a long-term approach to building companies and emphasizes ethical conduct. In addition to its investment activities, Morningside supports charitable initiatives in education, research and healthcare, including collaborations with Harvard T.H. Chan School of Public Health, UMass Chan Medical School, and the MIT Morningside Academy for Design.

Insight Partners is a global software investor that partners with growth-stage technology and software companies. Headquartered in New York City with offices in London, Tel Aviv, and Palo Alto, it concentrates on growth-stage software, internet, and data services, with notable focus areas including fintech, cybersecurity, AI/ML, DevOps, and healthcare. Founded in 1995, Insight Partners manages over $75 billion in regulatory assets under management and has invested in more than 750 companies worldwide, with over 55 portfolio companies achieving an IPO. The firm combines capital with hands-on, right-sized software expertise to support portfolio companies on their growth journey from first investment to IPO.

WindSail Capital Group is a Boston-based investment firm that provides growth capital and flexible debt solutions to companies advancing energy innovation and sustainability across industries. The firm focuses on direct lending to U.S. and Canadian businesses, offering a range of loan products including senior secured loans, junior secured loans, stretch loans, bridge financing, and debtor-in-possession loans to support growth, restructurings, or special situations. It targets energy services, cleantech, and related sectors, including early-stage and revenue-generating companies, with an emphasis on minimizing dilution through debt financing. Founded in 2013, WindSail positions itself as a growth capital partner enabling companies to scale while meeting capital-structure needs.

MassVentures is a Massachusetts-based venture capital firm that provides seed and early-stage funding to high-growth startups in the Massachusetts innovation economy, helping concepts move from idea to commercialization. Founded in 1978 as a quasi-public corporation by the Legislature of the Commonwealth, it is governed by an independent board and managed by experienced venture investors. The firm focuses on information technology, healthcare, cybersecurity, e-commerce, mobile, manufacturing, and robotics sectors in Massachusetts and operates accelerator programs to support portfolio companies. MassVentures leverages the state's entrepreneurial ecosystem, educated workforce, and centers of innovation to back early-stage ventures.

Matrix Partners is a San Francisco-based venture capital firm founded in 1977 that backs technology companies from idea through Series A and beyond. The firm focuses on software, AI, B2B, consumer, fintech, health tech, infrastructure, and related sectors, with a global footprint in the United States, India, and China. Its team comprises former founders and operators who work closely with portfolio companies and often join boards to support growth. Matrix Partners has backed a broad slate of successful companies in its decades-long history, including Apple, FedEx, Oculus, Zendesk, HubSpot, Canva, and Postmates, illustrating a pattern of helping developers and builders scale toward IPO or strategic exits. The firm's China arm extends its early-stage and growth investments in the Chinese market, reinforcing its international reach.

Kodiak Venture Partners is a venture capital firm that specializes in seed and early-stage investments, primarily in emerging technology sectors. The firm focuses on communications and wireless, semiconductor and equipment, software and services, Internet and new media, and life technology companies. Kodiak Venture Partners is based in Boston, Massachusetts, and primarily invests in Eastern North America, with particular attention to Boston, New York, and Eastern Canada. The firm typically makes investments ranging from $100,000 to $3 million and emphasizes building strong relationships with entrepreneurs to help develop business strategies, management teams, and essential alliances. Founded in 1999, Kodiak Venture Partners has a reputation for fostering high-growth industry leaders through a hands-on investment approach.

Accomplice is a seed-led venture capital firm based in Cambridge, Massachusetts, focused on early-stage technology startups. It invests in cybersecurity, eSports, data analytics, SMB-class software, emerging hardware platforms, and marketplaces. The firm pursues a community-driven approach, leveraging platforms such as AngelList, Boston Syndicates, Maiden Lane, Spearhead, BOSS, Rev, and TUGG to identify and support founders. While most investments are in Boston, its portfolio spans the United States, Canada, and Europe, reflecting an active geographic reach in New England and beyond.

Glasswing Ventures is a Boston-based venture capital firm founded in 2016 that specializes in early-stage investing in artificial intelligence, frontier technologies, and cybersecurity for enterprise applications. It backs pre-seed to startup and early-stage companies, primarily in North America, with a focus on the East Coast including Boston and New York areas. The firm leverages domain expertise and advisory networks to support founders who aim to transform markets with AI-powered and frontier tech solutions, particularly in enterprise software and security. Typical investments range from about 2 to 3 million dollars per company.

Romulus Capital is a Boston-based venture capital firm founded in 2008 that concentrates on early-stage technology companies. It typically supports seed and Series A rounds in the United States, with selective opportunities in India, the United Kingdom, and elsewhere, and it emphasizes software, SaaS, big data, and other technology sectors such as healthcare IT, education, real estate, energy, retail, and consumer Internet. Initial investments commonly start in the six-figure range and can scale to several million dollars as a company grows. The firm prioritizes company-building and ongoing partnership with founders, often backing entrepreneurs affiliated with top universities and incubators, including student-led Boston startups. Romulus Capital has a global investor base and seeks to back B2B and B2B2C businesses with the potential to become industry leaders.

Boldstart Ventures is a venture capital firm founded in 2010 by Ed Sim and headquartered in Miami, Florida, with partners in Boston, the Bay Area and London. It focuses on early-stage investments in technology companies, particularly software, cloud infrastructure, cybersecurity, SaaS and related developer-first sectors. The firm often acts as a first investor at company inception, providing pre-product rounds and helping founders reach product-market fit through its enterprise network and hands-on support. Notable early checks include companies such as Snyk, Kustomer and Superhuman. Boldstart emphasizes partnering with bold founders to build category-defining enterprise solutions, with occasional focus across the New York metro and broader U.S. tech ecosystem.

Walnut Venture Associates is a Massachusetts-based venture capital firm focused on seed and early-stage information technology companies in New England. Based in Boston, it typically invests 250,000 to 1,000,000 per financing and seeks board representation in portfolio companies, providing active involvement and strategic support. The firm helps entrepreneurs refine business plans, assemble management teams, develop financing strategies, and establish strategic partnerships, leveraging the experience of a group of seasoned entrepreneurs and investors. One member often serves on the board, while the full capabilities of the group are available to portfolio companies.

IA Ventures is a New York-based venture capital firm founded in 2010 that concentrates on seed- and early-stage investments in technology-driven companies, with emphasis on fintech and financial services, software, healthcare, and data-driven sectors. The firm targets startups developing machine learning, anomaly detection, predictive analytics, data visualization, and new systems for credit scoring and payment transfers, as well as solutions in fraud detection and data privacy. Typical investments range from $0.25 million to $0.75 million per transaction. IA Ventures pursues opportunities across the United States and internationally, including the Northeast Corridor, Israel, the United Kingdom, and the West Coast, focusing on software-enabled businesses with potential for rapid scale.

LaunchCapital is a venture capital firm based in New Haven, Connecticut, that funds seed and early-stage startups. It focuses on technology, consumer, and medical sectors and targets commerce, marketplaces, media and entertainment, enterprise software and services, data, finance, healthcare, and emerging technologies. The firm maintains offices in Boston, New York, New Haven, and San Francisco and pursues opportunities for exponential growth by providing equity investments and other capital support to startups in the initial development stage. By helping founders scale from concept to revenue, LaunchCapital aims to optimize early-stage capital structures and support sustainable growth for portfolio companies.

Citigroup is a diversified financial services company providing a broad range of financial products and services to consumers, corporations, governments, and institutions worldwide. It operates through two main segments: Global Consumer Banking, which includes retail banking, Citi-branded cards, and consumer finance, and Institutional Clients Group, which covers wholesale banking, investment banking, fixed income and equity sales and trading, foreign exchange, prime brokerage, research, corporate lending, cash management, trade finance, and securities services. The company maintains a global footprint across regions including Asia, Europe, the Middle East, Africa, North and Latin America, and emphasizes sustainability and social responsibility initiatives.

Underscore.VC is a Boston-based venture capital firm founded in 2015 that invests from seed through growth stages across the United States. It backs technology companies in sectors such as enterprise software, artificial intelligence and machine learning, fintech, insurtech, healthtech, e-commerce, the Internet of Things, and web3/blockchain, as well as data infrastructure, cloud software, and sensor-enabled industrial and home automation applications. With a focus on supporting bold entrepreneurs, the firm provides capital and strategic guidance to help startups accelerate product development and scale operations from pre-seed to Series A and beyond.

MPM BioImpact is a biotechnology investment firm based in Boston, Massachusetts, focused on early-stage venture investments and private/public impact in the United States. The firm targets opportunities in biotechnology, healthcare, and life sciences, supporting ventures that aim to advance medical innovation and deliver measurable societal outcomes.

Holtzbrinck Digital is the corporate venture capital arm of Holtzbrinck Publishing Group, headquartered in Munich with a global reach including offices in London and Boston. It focuses on digital science, digital education, content, marketplaces, and e-learning, seeking to back business models with strong market understanding and domain expertise. The company partners closely with founders and management teams to provide strategic and operational guidance, aiming to drive growth and create economic value. It invests in startups that have proven concepts, supports later-stage growth, and may acquire profitable businesses with potential to lead their domestic or international markets. The approach combines rigorous focus on investment fields with flexibility on transaction size and equity, leveraging its network to help portfolio companies scale to the next level.

Seae Ventures is a Boston-based venture capital firm providing early-stage and growth capital to healthcare service and technology companies, with a focus on minority- and women-led ventures, targeting opportunities across women's health, mental health, digital health, personalized medicine and genomics, artificial intelligence, data analytics, information technology, fintech, and tech-enabled services primarily in the United States, and prioritizing investments from women and BIPOC-led teams that support underserved populations to advance innovative health solutions.

Select Venture Partners is an early-stage investment management firm based in Fredericksburg, Virginia. Founded in 2014, it focuses on cloud services, enterprise software, SaaS, mobile apps, data analytics, and e-commerce. The firm targets seed, post-seed, and pre-Series A rounds in U.S. software companies, providing both capital and operational experience to help early-stage startups scale. With a team carrying extensive cross-industry experience and a track record of exits, it supports portfolio companies through hands-on guidance and a broad network. The investment scope emphasizes opportunities on the East Coast and across the Intermountain West, with a preference for software-driven businesses generating meaningful early momentum. The firm aims to bridge the funding and expertise gap for young software companies seeking to advance to Series A.

Victress Capital is a venture capital firm based in Boston, Massachusetts, established in 2016. The firm focuses on investing in technology-enabled consumer startups that are led by diverse leadership teams. By leveraging over 40 years of combined experience in consumer operations and investing, Victress Capital provides capital and resources to support the growth of visionary founding teams in the consumer sector. The firm employs a diversified investment strategy, aiming to foster innovation and drive success within its portfolio companies.

Rose Park Advisors is a Boston-based venture capital and investment firm founded in 2007. It concentrates on disruptive innovation opportunities across software, health tech, technology, media, and telecom, and pursues seed and early-stage venture investments as well as select public market opportunities. The firm provides capital and strategic guidance to portfolio companies, supporting growth across industries, geographies, and company stages. As a registered investment adviser, Rose Park Advisors structures its investment activities to help companies achieve scalable, transformative results.

BlueIO is a Boston-based startup studio founded in 2012 by Dave Furneaux that builds and funds new ventures across healthcare, technology, cybersecurity, biotech, energy, urban food access, community empowerment, and consumer goods.

Hongtai Capital Holdings is a private equity and venture capital firm based in Beijing, China, founded in 2014. It engages in direct investments and fund-of-funds strategies, targeting opportunities across technology intelligence, big data, artificial intelligence, financial technology, consumer education, healthcare, culture and entertainment, mobile internet, and advanced manufacturing. The firm invests in both non-listed companies and in firms listed on emerging boards, supports a broad range of stages from incubation and seed to expansion, and seeks to create value through industry consolidation, joint acquisitions, and exits via sales or listings. Typical investments are sized to support portfolio companies at early to late stages, with a preference for opportunities that may achieve IPO potential. Hongtai Capital maintains an international outlook, pursuing opportunities in Silicon Valley and Boston while headquartered in Beijing.

Eastern Link Capital is a China-focused investment firm that pursues late-stage and middle-market opportunities in qualified companies, with a focus on consumer spending and information technology sectors in China. It engages in private equity and venture capital investments across healthcare, information technology and consumer products and services, and is headquartered in Beijing with additional offices in Suzhou, Boston and Seattle.

Ten Eleven Ventures is a cybersecurity-focused venture capital firm founded in 2014 that maintains a global, stage-agnostic approach while primarily backing early-stage technology and cybersecurity companies in North America. The firm leverages its team, network, and operational expertise to help portfolio companies grow, address critical digital security needs, and scale to the next phase of development. It has raised over $1 billion in aggregate capital and has completed dozens of cybersecurity investments across stages worldwide.

Angels with Attitude is an angel investor group founded in 2000 and based in Seattle. It pools capital from its members to invest in early-stage companies across sustainability-focused sectors, including clean and renewable energy, environmental technology, and clean transportation; it also targets healthy organic foods and natural products as well as education. Geographically, the group supports ventures primarily on the West Coast from Vancouver to San Diego and on the East Coast from Boston to Washington, DC.

NextPoint Partners is a private equity and venture capital firm founded in 1990 and headquartered in Washington, D.C., with offices in Boston and New York. It pursues investments across a broad range of stages—from incubation and seed to late-stage and mature companies—and engages in turnarounds and bridge financings. The firm concentrates its activity in the Mid-Atlantic and New England regions, with a focus on software, internet, media, communications, and related information technology sectors, including SaaS, cybersecurity, and B2B services. Typical initial commitments range from $250,000 to $2 million, with total investments up to around $6 million. NextPoint Partners aims to support growth-oriented companies operating in software, internet and telecom-enabled markets, and seeks opportunities in mid-sized businesses with proven potential. The firm emphasizes regional expertise and industry knowledge to guide portfolio companies through different development stages and financing needs.

DM Capital is a venture capital and private equity firm headquartered in Shenzhen, China, with offices in Beijing, Guangzhou, and Wuhan, and international outposts in Zurich, Toronto, and Boston. Founded in 2001, the firm pursues early-stage and growth investments as well as PIPE investments, focusing on healthcare and technology innovation. Its activities cover innovative medical technologies, artificial intelligence, big data, biomedicine, genetic technologies, stem cell and organ repair, medical devices and equipment, professional clinical services, dentistry, and related biomedical technologies. The firm also engages in industrial investments and financial advisory services, supporting strategic partnerships and cross-border opportunities.

HLM Venture Partners is a Boston-based venture capital firm focused on healthcare, investing in early-stage and growth companies in the United States across healthcare technology, healthcare services, and life sciences. Drawing on extensive experience and a broad network, the firm supports more than 60 privately held healthcare companies as they develop and scale toward market leadership.

Boston Capital Ventures is a Boston-based private equity and venture capital firm founded in 1982 that targets early-stage investments in technology companies in the United States, including information technology, telecommunications, consumer products and services, retail, transportation, and software.

Joint Effects is a venture capital firm based in Boston, Massachusetts, founded in 2022. It invests in fintech, deep tech, web3, and health technology sectors.

Vinyl Capital is a venture capital firm founded in 2021 and based in Boston, Massachusetts. It focuses on investing in companies across consumer-oriented and technology-enabled sectors, including B2C, media, ad tech, gaming, and the broader technology, media, and telecom (TMT) industries.

Established in 2011, Surgical Intelligence is a company builder focused on investing in and supporting innovative technologies that bridge the artificial intelligence gap in healthcare, with a particular emphasis on surgical technologies.

Visible Hands is a venture capital firm and accelerator founded in 2020 and based in Boston, Massachusetts. It provides funding and hands-on support to early-stage startups, helping them advance product development, validation, and market entry through its program and network. The organization invests across a broad range of technology-enabled sectors, including healthcare devices and wearables, software as a service, real estate technology, mobility, education technology, fintech, e-commerce, consumer products, sustainability, and related fields, with a focus on hardware, software, and integrated solutions. Visible Hands positions itself as a partner to founders seeking practical guidance, strategic mentorship, and resources to scale startups from prototype to growth.

F-Prime Capital is a venture capital investment firm based in Cambridge, Massachusetts. Founded in 1969 with roots in Fidelity Investments, it backs entrepreneurs across technology and life sciences, investing in sectors such as crypto, enterprise information technology, fintech, frontier technologies, health information technology and services, medtech and therapeutics, with a global reach across the Americas, Europe and Asia.

G20 Ventures is a Boston-based venture capital firm founded in 2013 that provides early traction capital to East Coast enterprise technology startups. It focuses on early-stage investments in enterprise software, infrastructure and cloud-based solutions, prioritizing technology risk over market risk and generally avoiding 100% consumer-facing businesses. The firm seeks a core team with at least two members, including a technologist with domain experience and a business leader who understands the buyer and go-to-market strategy. A product in market with customer validation is preferred. Its typical Series A investment ranges from 2 to 5 million dollars, and capital is reserved for earlier-stage rounds to support companies through multiple financing events.

Threshold Ventures is an early-stage venture capital firm based in Menlo Park, California. The firm pursues a high-conviction investment strategy and partners with entrepreneurs to build and scale innovative software, consumer, enterprise, and healthcare technology companies, providing capital and strategic support to help startups reach product-market fit and accelerate growth.

Founder Collective is a seed- and early-stage venture capital firm founded in 2009 by entrepreneurs who have built and exited technology companies. Headquartered in Cambridge, Massachusetts, with an office in New York, the firm makes early investments across the United States and globally. It is industry-agnostic but prefers ventures with an information technology component, including software and TMT-enabled businesses. The firm focuses on supporting founders at the seed and early stages, drawing on the experience of its partners who have firsthand startup experience.

Hyperplane Venture Capital is a Boston-based early-stage venture capital firm that funds technology startups. The firm focuses on machine intelligence and data companies, backing founders who leverage AI, sensor technology, and cloud computing to tackle difficult problems and build software and data-driven businesses. Hyperplane seeks exceptional teams and aims to advance solutions at the intersection of perception, communication, intelligence, and insight.

Alumni Ventures Group is a venture capital firm based in Manchester, New Hampshire, established in 2013. It targets individual accredited investors who previously had limited access to venture capital by enabling alumni from top entrepreneurial schools to invest together in ventures led by fellow alumni. The firm backs companies with an alumni connection and an institutional lead investor with sector expertise. It offers focused funds that provide accredited investors access to a diversified venture portfolio by type, sector, stage, and geography. The organization engages in seed, early-stage, and late-stage pre-IPO investments across technology, consumer, financial services, health care, life sciences, and other sectors.

Innovius Capital is a San Francisco-based venture capital firm that invests in software-as-a-service and financial technology companies. The firm also provides consulting and financial services and operates as a registered investment adviser.

Atlas Venture is a Cambridge, Massachusetts–based venture capital firm founded in 1980 that specializes in life sciences and technology. It pursues seed-led venture creation and early-stage investments to build scalable companies in biopharmaceuticals, diagnostics, medical devices, and related biomedical technologies, as well as software and other technology sectors. The firm often leads investments and seeks board representation to support portfolio companies as they grow toward acquisition or public offerings. Atlas operates with dedicated life sciences and technology teams and maintains an international footprint across the United States and Europe.

Tiger Global Management is an investment firm founded in 2001 by Charles (Chase) Coleman. It allocates capital across public and private markets worldwide, with a focus on technology-enabled growth opportunities. The firm pursues public equity strategies, including long/short and growth investments, and private equity across early- to late-stage companies in multiple industries, seeking high-quality growth opportunities and guiding portfolio companies through their lifecycle.

Two Sigma Ventures is a New York City-based early-stage venture capital firm backed by Two Sigma Investments. It provides capital and access to a proprietary network of experts and startup resources to help data- and computing-driven entrepreneurs build the future. The firm focuses on seed to early-stage opportunities across sectors including infrastructure tools, healthcare, real estate, consumer hardware, information technology, artificial intelligence, big data, biotechnology, and financial technology, leveraging the parent company's data-driven engineering capabilities.

Omega Funds is a Boston-based venture capital firm that backs life sciences, biotechnology, health care technology and related software-enabled solutions. Founded in 2004, the firm invests across the United States and Europe, targeting pharmaceuticals, biotechnology, oncology, immunology, rare diseases, precision medicine, digital health, healthtech and cybersecurity. It manages multiple funds, including Omega Fund IV, V, VI and VII, and supports companies from early to growth stages. The firm serves as an investment adviser to its funds and seeks to build a diversified portfolio at the intersection of science and technology.

Singtel Innov8 is the corporate venture capital arm of Singtel Group. Established in 2010 and based in Singapore with offices in San Francisco and Tel Aviv, it invests in early-stage technology startups worldwide and partners with them to apply innovations across Singtel’s business. The focus is on software and technology sectors that can drive quantum changes in network capabilities, next-generation devices, and digital services, ultimately improving customer experience. Beyond funding, Singtel Innov8 serves as a gateway to the Singtel Group’s resources and expertise, helping startups scale internationally while giving the Group access to emerging technologies.

RRE Ventures is a New York-based venture capital firm that backs early-stage technology companies, primarily in seed and Series A rounds, across a broad range of sectors. Founded in 1994, the firm looks for innovative, scalable business models and supports companies aiming to leverage technology to create value. Its investment scope spans artificial intelligence, climate, consumer technology, cryptocurrency, enterprise software and services, financial technology, healthcare, media, real estate, robotics, and space, with activity across the United States and Canada.

Sofinnova Partners is an independent venture capital firm based in Paris, France, focusing on life sciences from seed to later-stage investments. It backs startups, early-stage companies, corporate spin-offs and occasionally turnaround situations in biopharmaceuticals/biotech, medical devices, and industrial biotechnology. The firm typically takes a lead or cornerstone role, often serving as the first institutional investor in Series A rounds, and actively supports portfolio companies through formation and beyond, including board participation. The firm manages more than €2 billion in life sciences assets.

Foundry Group is a Boulder, Colorado-based venture capital firm founded in 2007 that specializes in information technology, Internet and software companies across North America. It funds both early-stage and later-stage ventures and has launched multiple funds, including a fifth fund of about $225 million. Since inception it has invested in more than 100 companies as institutional investors and in more than 50 as angel investors, with a focus on software, digital services and related technology sectors.

MRL Ventures Fund is the Cambridge, Massachusetts-based venture capital arm of Merck Research Laboratories, the research and development division of Merck & Co. It invests in seed and early-stage therapeutics opportunities rooted in translatable breakthrough science, with the goal of delivering differentiated medicines to improve human health.