Cary, North Carolina-based venture capital firm focused on early-stage seed investments in B2B software and related technology in the Southeast, with a particular emphasis on North Carolina. Founded in 2015, the firm partners with entrepreneurs to validate ideas and bring solutions to market, providing capital through its seed program and supporting portfolio companies with a broad adviser and mentor network. Typical investments are in the low hundreds of thousands of dollars, with a preference for minority stakes, and the firm targets software, fintech, healthtech, and other business software sectors.

IDEA Fund Partners is a private equity and venture capital firm founded in 2007 and headquartered in Chapel Hill, North Carolina. It targets early-stage technology companies in North Carolina and the southeastern United States, with investments across technology, software, automation, big data, and healthcare. The firm supports entrepreneurs applying technology and business model innovations to industries facing digital disruption at the earliest stages, with a focus on underserved people, places, and stages.

VentureSouth is an angel investment group and early-stage venture organization based in Greenville, South Carolina, operating across the Southeastern United States. It develops and manages multiple angel investment groups and funds, drawing more than 550 investors across about a dozen groups, and has deployed over $80 million in more than 100 companies since its inception in 2008 (initially as the Upstate Carolina Angel Network). The organization focuses on startup and early-stage opportunities, particularly in manufacturing, logistics and healthcare sectors, and aims to connect entrepreneurs with capital and strategic support to accelerate growth.

Hatteras Venture Partners is a Durham, North Carolina-based venture capital and private equity firm founded in 2000 that focuses on funding life sciences and healthcare companies in the United States. Its activities center on biopharmaceuticals, medical devices, diagnostics, healthcare information technology, and related human medicine opportunities, with investments spanning pre-seed to growth stages. The firm typically makes initial investments in the range of half a million to four million dollars and participates in follow-on rounds up to around twenty million, and it operates as a Small Business Investment Company (SBIC). Hatteras also backs adjacent sectors such as software and health services within the Southeast, leveraging an experienced team to support value creation in early-stage biomedical ventures.

Bull City Venture Partners is a venture capital firm based in Durham, North Carolina, focused on early-stage investments in technology and healthcare companies. The firm targets startups in the Southeast and Mid-Atlantic regions, with a preference for B2B and tech-enabled businesses across software, mobile, e-commerce, health tech, logistics, cloud computing, fintech, and internet services. It backs companies from seed to growth stages, providing capital and strategic support, including governance participation to help accelerate growth and secure follow-on funding. The firm prioritizes innovation and growth potential, partnering with founders to scale operations, expand market reach, and build enduring businesses.

Alexandria Venture Investments is the strategic venture capital arm of Alexandria Real Estate Equities. It provides seed through growth capital to life science and technology companies developing breakthrough therapies, diagnostics, research tools, agrifoodtech, agtech, digital health, and related platforms. Backed by the parent company’s industry experience and scientific advisory network, the firm leverages long-standing relationships and domain expertise to support early to growth-stage ventures aiming to translate scientific advances into practical healthcare and technology solutions.

Excelerate Health Ventures is a Durham, North Carolina-based venture capital firm founded in 2013 that invests in early‑stage healthcare technology, including healthcare software and digital health solutions, primarily in North America. The firm targets seed and early‑stage opportunities in healthcare and related technology sectors and leverages a network of strategic partners from pharma, providers, and payers to accelerate adoption and revenue for portfolio companies.

SOSV is a global venture capital firm based in Princeton, New Jersey, founded in 1995, that focuses on seed to growth investments in deep technology across health, environmental tech, hardware, robotics, and cross border software, with a particular emphasis on Asia. The company runs accelerator style startup development programs, including HAX and IndieBio, which provide facilities, engineering resources, and lab equipment to help founders accelerate product development, acquire customers, and attract later stage funding. SOSV pursues a limited number of high potential startups, offering extensive hands on support to speed commercialization and scale, and aims to back innovations that improve human and planetary health.

Service Provider Capital is a Colorado-based venture capital firm founded in 2014 that funds seed-stage technology companies across domains such as artificial intelligence, machine learning, blockchain, cybersecurity, fintech, e-commerce, education technology, hardware, robotics, information technology, health tech, and cannabis. The firm also co-invests in Series A rounds led by institutional venture funds, providing capital and guidance to startups in the United States, including the Midwest and Southeast regions.

Rex Health Ventures is the corporate venture capital arm of UNC Rex Healthcare, based in Raleigh, North Carolina. Founded in 2012, it targets early-stage investments in healthcare and related technology sectors, including healthcare software as a service, life sciences, and health technology, primarily in the United States. It partners with entrepreneurs and companies to bring innovative products and services to the healthcare marketplace.

Established in 2021, Pisgah Fund is a venture capital firm headquartered in Asheville, North Carolina. It invests in startups and high-growth companies that offer innovative products or services, focusing on those that enhance regional health and create jobs for Western North Carolina residents.

Morningside is a Boston-based investment firm founded in 1986 as a family office for the Chan family. It makes venture capital investments in companies with novel science and technology, with deep expertise in life sciences, digital health, artificial intelligence, materials, and technology. The firm takes a long-term approach to building companies and emphasizes ethical conduct. In addition to its investment activities, Morningside supports charitable initiatives in education, research and healthcare, including collaborations with Harvard T.H. Chan School of Public Health, UMass Chan Medical School, and the MIT Morningside Academy for Design.

Intersouth Partners is a venture capital firm based in Durham, North Carolina, founded in 1985. It concentrates on seed and early-stage investments in technology and life sciences across the Southeast United States, including software, information technology, semiconductors, digital media, digital health, medical devices, biopharmaceuticals, agricultural biotechnology, and manufacturing. The firm aims to take leadership roles in its portfolio companies, often serving on boards, and focuses on opportunities in the Southeast corridor from Baltimore to Florida, including Washington, DC, the Research Triangle region, and Atlanta.

Triangle Angel Partners is an angel investment group and principal investment firm based in North Carolina that backs early-stage technology, media, telecommunications, software, and life sciences companies. It focuses on opportunities in and around North Carolina’s Research Triangle Park and surrounding Chapel Hill area, and its members provide mentorship and access to a broad network of potential investors, customers, strategic partners, and management talent.

The Aurora Funds is a North Carolina based venture capital firm established in 1994 and based in Cary, with an additional office in Durham. It historically focused on seed and early-stage investments in healthcare and information technology, including biotechnology, therapeutics, medical devices, healthcare services, and health IT, as well as software, internet infrastructure, data communications, semiconductors, photonics, and nanotechnology. The firm typically invested in seed to Series A rounds, with initial checks around $50,000 to $2.5 million and total commitments of roughly $4-8 million across multiple rounds, often seeking to lead or co-lead and secure a board seat. Its geographic focus centered on the Southeastern and Mid-Atlantic United States, and it pursued dual investments in areas such as healthcare IT and informatics and bio-medical engineering applications. Targeted enterprise values generally ranged from the low to mid tens of millions with EBITDA up to about $75 million. The firm is no longer investing.

One Better Ventures is a Raleigh, North Carolina-based venture capital firm that concentrates on the consumer sector, investing in and supporting mission-driven brands with sustainable business models. The firm advises, invests in, and incubates consumer ventures that aim to deliver positive social or environmental impact, prioritizing principled, patient partnerships and long-term value. Its approach spans working with established and emerging brands to scale responsible consumer products and services, guided by a commitment to service and corporate citizenship. The firm also pursues philanthropy, donating a portion of profits to charity and sharing profits with employees.

The Startup Factory is an accelerator based in Durham, North Carolina, that provides seed capital and mentorship to early-stage startups. The three-month program offers participating companies approximately 7.5% equity in exchange for $50,000 in seed funding, structured coaching, and access to a network of angels, veteran startup founders, and experienced technology experts. Upon successful completion, startups may qualify for follow-on funding, including convertible notes ranging from $20,000 to $150,000. The accelerator targets startups in web, mobile, software, tourism, hospitality, and education sectors.

UNC Kenan-Flagler Private Equity Fund is a student-run private equity fund affiliated with the University of North Carolina at Chapel Hill's Kenan-Flagler Business School. Founded in 2007 and based in Chapel Hill, North Carolina, it engages in private equity and venture capital activities across early and late stages, buyouts, growth capital, mezzanine financing, and real estate investments. The fund targets portfolio company investments of roughly $0.1 million to $0.15 million with enterprise values between $20 million and $125 million and co-invests with partner private investment firms. Operating in an educational setting, it aims to deliver real returns for investors while providing students with hands-on investment experience.

Sustainable Food Ventures is a venture capital firm based in Durham, North Carolina, focused on funding early-stage food technology companies developing cell-based, plant-based, and recombinant products.

Battery Ventures is a technology-focused venture capital firm based in Boston, Massachusetts, founded in 1983. It invests in category-defining technology companies across sectors such as application software, infrastructure software, consumer internet and mobile services, industrial technologies, and life science tools. The firm supports growth across various stages and geographies, including the United States, Europe, and Israel, with emphasis on software, TMT, and related tech-enabled opportunities. As a registered investment adviser, Battery Ventures backs companies that build scalable platforms and transformative products, helping them compete in rapidly evolving markets.

Founded in 2020 and based in Raleigh, North Carolina, Piedmont Capital Investments is a venture capital firm that invests in transformative science and technology companies, with an emphasis on resilience in American sectors such as electrification, manufacturing, and defense.

Alumni Ventures Group is a venture capital firm based in Manchester, New Hampshire, established in 2013. It targets individual accredited investors who previously had limited access to venture capital by enabling alumni from top entrepreneurial schools to invest together in ventures led by fellow alumni. The firm backs companies with an alumni connection and an institutional lead investor with sector expertise. It offers focused funds that provide accredited investors access to a diversified venture portfolio by type, sector, stage, and geography. The organization engages in seed, early-stage, and late-stage pre-IPO investments across technology, consumer, financial services, health care, life sciences, and other sectors.

Wilmington Investor Network is an angel investment network based in Wilmington, North Carolina. It mobilizes individual investors to fund early-stage technology, biotechnology, and medical device companies located in eastern North Carolina and nearby South Carolina. Investments typically range from roughly $0.2 million to $0.5 million per round.

CFV Ventures is an early-stage venture capital firm established in 2017 and based in Charlotte, North Carolina. It specializes in investing in companies within the fintech sector, focusing on innovative solutions that address the evolving needs of financial technology. As a part of RevTech Labs, CFV Ventures aims to support and foster growth in emerging fintech businesses, providing not just capital but also strategic guidance to help them navigate the complexities of the financial landscape.

SJF Ventures is a venture capital firm headquartered in Durham, North Carolina, with offices in New York and San Francisco. Founded in 1999, the firm concentrates on growth equity investments in the United States, with a focus on cleantech, sustainability, and technology-enabled services. It backs companies across energy, efficiency, circular economy, logistics, sustainable food, health and education technology, and enterprise software, typically investing 1 to 10 million per portfolio company and often participating in syndicates. SJF seeks teams with scalable models, strong profitability, and potential for rapid sales and premium exits, and often takes board seats to guide strategic growth. The firm emphasizes environmental and social impact alongside financial returns, pursuing opportunities in energy-related impact and climate tech.

Noro-Moseley Partners is a venture capital and growth equity firm based in Atlanta, Georgia, founded in 1983. It invests in technology and healthcare companies across the United States and Canada, with a focus on the Southeast. The firm backs early-stage and growth-stage companies in software, information technology, healthcare IT, data analytics, telemedicine, and other technology-enabled services, as well as related business services. It aims to support portfolio companies through multiple stages of growth and leverages its industry experience and network to help accelerate scale.

Good Growth Capital is a venture capital firm founded in 2015 and based in Charleston, South Carolina. It is a majority women-owned firm that invests in early-stage life sciences, green tech, hard sciences, and data science companies. The firm emphasizes technology commercialization, seeking to fund and grow defensible technologies that address pressing societal needs. It supports early-stage ventures across sectors including pharmaceuticals and biotechnology, software, energy, and materials, aiming to deliver meaningful returns while advancing scientific and technological progress.

Duke Capital Partners is a venture capital firm based in Durham, North Carolina, founded in 2015. It focuses on investing in consumer, enterprise, and life sciences sectors and supports early-stage companies. The firm operates an associate program that educates the next generation of investment professionals and startup founders.

Sapphire Ventures is a global software-focused venture capital firm that backs technology companies across growth and early stages. With teams in Austin, London, Palo Alto, Menlo Park and San Francisco, it partners with management teams and other venture funds to scale companies toward category leadership. The firm manages a substantial asset base and its portfolio spans software, information technology, fintech, cybersecurity, artificial intelligence, cloud and related technologies. A dedicated Portfolio Growth team provides hands-on support, tools and resources to help portfolio leaders execute growth strategies and scale operations, while Sapphire Ventures also operates platforms such as Sapphire Partners and Sapphire Sport to support portfolio companies and select venture fund initiatives. The firm emphasizes long-term relationships and strategic value creation through its global footprint and operator driven approach.

FJ Labs is a New York-based venture capital firm founded in 2015 by Fabrice Grinda. It is stage-agnostic and focuses on marketplaces and consumer-facing startups, making seed and Series A investments. Typical checks range from 50,000 to 5,000,000 dollars. The firm supports early-stage companies across sectors such as e-commerce, fintech, ad tech, mobile, and software-as-a-service, seeking opportunities with high growth potential in the United States and internationally. Its portfolio includes a mix of consumer brands and marketplace platforms, reflecting an emphasis on business models that connect buyers and sellers or enable direct consumer experiences. FJ Labs aims to back entrepreneurs building scalable, disruptively positioned products and services, often partnering with founders early in their development to help accelerate growth.

An angel investment group based in Winston-Salem, North Carolina, founded in 2021, that provides seed-stage funding to companies headquartered in or committed to relocating to the greater Winston-Salem area. The organization seeks early-stage ventures with scalable business models and readiness for growth, focusing on sectors including healthcare, information technology, data analytics, apparel, education, virtual reality, automotive technology, and unmanned aviation. Typical investments range from $100,000 to $300,000 and can be in the form of convertible notes or preferred equity; the group may lead, co-lead, or follow in rounds and may request a board seat or observer seat when leading an investment round.

Bootstrap Advisors is a Durham, North Carolina-based venture partner founded in 2015 by three partners who have collaborated for more than a decade. The firm positions itself as hands-on transformers rather than mere incubators or investors, investing their time and own capital to turn ideas into scalable products and companies. They work with entrepreneurs to develop brands and businesses, leveraging a history of starting multiple ventures, scaling several to multi-million-dollar levels and exiting others to strategic buyers. Bootstrap Advisors seeks opportunities across sectors including B2C, information technology, manufacturing, food technology, and software as a service, with a focus on the Southeast United States. The team emphasizes practical support and active involvement to help early-stage concepts reach market success and growth, combining entrepreneurial experience with a disciplined approach to building sustainable businesses.

Southern Capitol Ventures was a Raleigh, North Carolina-based venture capital firm that invested primarily in early-stage technology companies in the Southeast and Mid-Atlantic regions, focused on software, e-commerce, digital media, mobile, and healthcare information technology, and pursued opportunities in later-stage investments and spinouts with larger venture funds; it ceased operations and liquidated its funds on December 31, 2024.

Frazier Healthcare Partners is a Seattle-based investment firm founded in 1991 that specializes in healthcare. It provides growth capital and venture investments to healthcare companies across the United States, Canada and Europe, spanning healthcare services, medical devices, pharmaceuticals and biotechnology, life sciences, oncology and wellness. The firm maintains dedicated Growth Buyout and Life Sciences teams and takes an active, hands-on approach to building portfolio companies through its network of healthcare executives, advisers and industry experts. It funds companies at multiple stages, from early venture to growth equity, and seeks to help them scale through strategic guidance, operational support and capital optimization.

Kapstone Medical is a full‑service provider that partners with physician inventors and manufacturers of all sizes to develop and commercialize new medical devices. It offers design, prototyping, patenting, quality systems, and regulatory approvals, as well as product development, quality management, and project management solutions. Its services cover engineering, intellectual property protection, quality assurance, and supply chain management. Based in Charlotte, North Carolina, the company was founded in 2007 by John Kapitan.

Southeast Interactive Technology Funds was a venture capital firm founded in 1995 in Research Triangle Park, North Carolina, with an additional office in Redwood City, California. It invested across information technology and communications, including enterprise software, internet infrastructure, and related sectors, spanning early to late stages. The firm managed four funds and supported portfolio companies through sourcing, analysis, financing, growth, and exits, using a proactive, hands on approach aligned with management. It relied on a technical advisory board and venture partners to provide industry, financial, and operational guidance. It built national and global networks of co-investors and limited partners, including strategic and global investors. The firm is now out of business.

Cisco Systems is a global technology company that designs, manufactures and sells networking hardware, software and related services. It offers routers, switches, network security products, wireless and mobility solutions, collaboration tools, data center technologies and observability software. Cisco serves businesses, organizations, service providers and individuals to build and manage networks, enable communications and enhance connectivity across industries. The company provides services in addition to its products, including technical assistance and advanced services, and manufacturing is largely outsourced with a large worldwide sales and marketing presence. With about 80,000 employees, Cisco is a leading provider of networking equipment and software, with a broad portfolio that includes security, collaboration (Webex) and enterprise networking solutions.

Bioventure Partners is a venture capital firm and growth advisory based in Chapel Hill, North Carolina. It focuses on life sciences and healthcare, investing in early-stage, technology-driven startups and supporting high-impact companies through growth.

Contender Capital is a micro-venture capital firm based in Raleigh, North Carolina. Founded in 2000, it concentrates on technology sector investments.

Echo Health Ventures is a venture capital firm based in Seattle, Washington, founded in 2016, with offices in Durham, Portland, and Seattle. It invests in healthcare, health technology, insurance technology, and digital health companies across the United States. As a stage-agnostic investor, it aims to accelerate portfolio companies' innovations and help them scale nationally, offering more than capital through deep, high-value relationships and strategic support.

Teall Investments, founded by Ben C. Sutton, Jr. in 2017, is a privately held portfolio of investments in innovative lifestyle brands and services with high growth potential. Headquartered in Winston-Salem, North Carolina, with additional offices in Atlanta and San Francisco, Teall Investments is led by a team of experienced executives. The company focuses on partnering with brands that offer unique market opportunities and have the potential for significant growth in the lifestyle sector.

Malin Corporation is a Dublin, Ireland-based venture capital investment firm focused on life sciences and healthcare technology. Founded in 2015, it backs private companies in oncology, immunology, and genetic diseases, providing long-term capital and operational expertise to accelerate growth and position portfolio firms for IPO or sale.

Gray Ventures is a venture capital firm headquartered in Atlanta, Georgia. It focuses on early-stage technology investments, particularly B2B SaaS companies in the southeastern United States. The firm typically participates in seed to Series A rounds with investment sizes around 0.5 to 3 million dollars. It generally seeks minority stakes and may secure a board seat or observer rights, often acting as a lead investor or co-investor with other professional investors. Gray Ventures manages multiple funds, including Gray Ventures I, Gray Ventures III, and Gray Ventures IV.

Next47 is a global independent venture firm backed by Siemens AG that invests in enterprise-focused startup companies leveraging emerging technologies. It pursues fast decision-making and works closely with the teams it backs to unlock maximum potential. The firm leverages Siemens' global footprint and ecosystem spanning multiple industries and regions to support portfolio companies.

RTP Angel Fund is an angel group established in 2023 and located in Durham, North Carolina. The organization focuses on investing in early-stage companies within North Carolina and the Southeastern United States. RTP Angel Fund aims to support these companies in their growth and scaling efforts, providing not only financial backing but also guidance to help them navigate the challenges of early development.

Leeds Illuminate is an impact investment firm based in Chapel Hill, North Carolina, that funds high-growth companies in the higher education sector. It partners with innovators to expand, improve, and accelerate learning outcomes, seeking to align financial returns with social impact across all stages of education and development.

Founded in 2010, Acorn Innovestments is a venture capital investment firm based in Durham, North Carolina. It focuses on seed-stage and early-stage investments, primarily in manufacturing, environmental technology, and advanced materials sectors.

SierraMaya360 is a venture capital firm focused on seed and early-stage investments, leveraging a team of industry veterans and a broad network to identify and back technology-driven startups globally. Based in Boston with offices in New York, Charlotte, San Francisco and Los Angeles, the firm pursues opportunities across high-tech sectors such as mobile, ad tech, gaming, consumer web and e-commerce, Internet of Things, healthcare information technology, financial technology, and media-enabled ventures including film, entertainment venues, influencer marketing and branded video content, as well as virtual and augmented reality, drone technologies and machine learning. It originated from the Sierra Maya Ventures angel fund and seeks to support early-stage companies worldwide through its cross-market reach in entertainment, sports and technology.

Resilient Ventures is a venture capital firm founded in 2018 and based in Durham, North Carolina. It invests in companies across consumer, technology, consumer products, impact, health, and service sectors, with a mission to disrupt systemic economic injustice by expanding access to capital, networks, and opportunities.

First Flight Venture Center is an incubator and venture capital firm based in Durham, North Carolina, founded in 1991. It focuses on early-stage technology and biotechnology companies, primarily those based in or relocating to North Carolina and the Research Triangle Park area. The organization provides early-stage investments typically ranging from about $20,000 to $500,000, along with office and laboratory space, flexible leases, shared business services and equipment, technology support, assistance in obtaining financing, and management guidance to its portfolio companies.