Triangle Tweener Fund, established in 2021 and based in Raleigh, North Carolina, is a venture capital firm focused on investing in early-stage, high-technology startups within the Triangle area, which includes Raleigh, Durham, and surrounding regions. The firm aims to build a comprehensive index of private company investments that meet its specific 'Tweener List' criteria, targeting promising ventures at a critical stage of their development. By concentrating on seed and early-stage investments, Triangle Tweener Fund seeks to support the growth of innovative companies that have the potential to contribute significantly to the local economy and the tech landscape.

Founded in 2015, Cofounders Capital is a venture capital firm based in Cary, North Carolina. It specializes in early-stage investments, focusing on business-to-business software companies in the Southeast region, particularly North Carolina. The firm invests an average of $0.3 million to $0.4 million per round, taking minority stakes.

IDEA Fund Partners, established in 2007, is a Chapel Hill, North Carolina-based venture capital firm. It specializes in early-stage investments, focusing on technology-driven companies in the Southeast region of the United States. The firm's investment focus includes sectors such as technology, software, automation, big data, and healthcare. IDEA Fund Partners is known for its experience and active approach, supporting entrepreneurs who are innovating in industries at the early stages of digital transformation, with a particular emphasis on underserved markets.

VentureSouth is a venture capital firm based in Greenville, South Carolina, specializing in startup and early-stage investments. The firm focuses primarily on manufacturing, logistics, and healthcare sectors, targeting opportunities in the Southeastern United States, particularly the Carolinas and surrounding areas. Since its founding, VentureSouth has developed a network of over 550 investors through various angel investment groups, making it one of the largest organizations of its kind in the country. The firm typically invests between $0.25 million and $2 million for a preferred equity stake of 15% to 35%, aiming for companies that can potentially deliver a 50% annualized rate of return within a 3-5 year timeframe. VentureSouth does not engage in common equity or debt investments, and it rarely invests in convertible debt.

Founded in 2000, Hatteras Venture Partners is a venture capital firm based in Durham, North Carolina. It specializes in early-stage investments in life sciences and healthcare companies, with a focus on biopharmaceuticals, medical devices, diagnostics, and healthcare IT. The firm primarily invests in companies located in the Mid Atlantic and Southeastern United States.

Alexandria Venture Investments is the strategic venture capital arm of Alexandria Real Estate Equities. Based in Pasadena, California, it provides long-term strategic capital to innovative life sciences and technology companies developing breakthrough therapies, diagnostics, and platforms across biopharma, digital health, agrifoodtech, agtech, and related healthcare fields. Established in 1996, the firm invests across seed, early, and growth stages and leverages its deep industry knowledge, extensive investor networks, and scientific advisory resources to support portfolio companies. The unit also pursues opportunities at the intersection of real estate, life sciences, and technology, reflecting its parent company's sector focus and integrated ecosystem approach. It aims to help entities advance human health by partnering with founders to scale transformative technologies.

Bull City Venture Partners is a Durham, North Carolina-based venture capital firm founded in 2012 that makes early-stage investments in technology, healthcare, and related sectors in the Southeast and Mid-Atlantic United States. The firm focuses on B2B and tech-enabled businesses across software, mobile, e-commerce, health tech, cloud computing, fintech, internet services, and logistics, providing capital and strategic support, often taking a board seat and helping secure follow-on capital for growth rounds.

Excelerate Health Ventures is a healthcare-focused venture capital firm based in Durham, North Carolina, in the Research Triangle Park area. Founded in 2013, it pursues seed- and early-stage investments in healthcare technology, including healthcare software and digital health, with a preference for SaaS and B2B-enabled solutions. The firm targets opportunities across North America and supports portfolio companies by leveraging a network of strategic partners from pharma, providers, and payers to accelerate adoption and revenue.

SOSV is a global venture capital firm that supports early-stage startups through active, founder-first development programs. Its flagship initiatives HAX and IndieBio provide facilities, engineering resources, services, and laboratory equipment to accelerate product development and prepare companies for subsequent funding rounds. SOSV focuses on deep technology across health, environmental, and cross-border software sectors, aiming to solve human and planetary health challenges. In addition to providing capital, the firm emphasizes intensive programmatic support to help portfolio companies move quickly from seed toward growth, including customer acquisition and scale. The firm operates globally with a bias toward startups targeting rapid international expansion, especially in Asia, and tends to back a small cohort of high-potential companies to accelerate their progress and attract leading investors.

Founded in 2012, Rex Health Ventures invests in and partners with early-stage healthcare companies to facilitate innovation and improve patient care. They support the discovery and development of new treatments, tools, products, and services.

Service Provider Capital is a venture capital firm established in 2014 and based in Colorado. The firm focuses on early-stage investments, notably seed-stage opportunities, and participates as a co-investor in Series A rounds led by institutional venture funds. Its portfolio interests span a broad range of technology sectors, including artificial intelligence, machine learning, blockchain, cybersecurity, e-commerce, education technology, fintech, hardware, information technology, robotics, health, and cannabis.

Intersouth Partners is a Durham, North Carolina–based venture capital firm founded in 1985 that concentrates on seed and early-stage investments in technology and life sciences. It seeks to be a lead or co-lead investor, often participating in the first institutional round with initial investments in the range of several hundred thousand to several million dollars and pursuing a total investment across rounds around ten to twelve million dollars. The firm emphasizes equity investments and typically seeks a board seat on portfolio companies, aiming to support growth in sectors such as software, semiconductors, communications, digital media, clean technology, security, medical devices, biopharmaceuticals, agricultural biotechnology, and biomaterials. Its geographic focus centers on the Southeast, including the Research Triangle area, Washington, DC, Atlanta, and the broader corridor from Baltimore to Florida. The firm is known for its active engagement and long-standing experience in building early-stage technology and life sciences companies.

The Aurora Funds is a North Carolina-based venture capital firm founded in 1994 that concentrates on early-stage investments in healthcare and information technology. It supports seed and Series A rounds, targeting companies from pre-product to early revenue, with initial investments typically ranging from 50,000 to 2.5 million and total financing of about 4 to 8 million across successive rounds. The firm looks to be lead or co-lead and often seeks a board seat in portfolio companies. Based in Cary, with an additional office in Durham, it provides resources to help healthcare and information technology startups grow.

GE Equity invests globally across various sectors, focusing on established companies with high growth potential. It takes minority ownership positions and offers growth capital, buy-out co-investments, secondary direct purchases, recapitalizations, and LP investments.

Founded in 2014, Eshelman Ventures is a venture capital firm based in Wilmington, North Carolina. It focuses on investing in private healthcare companies.

One Better Ventures is a venture capital firm established in 2013 and located in Raleigh, North Carolina. The company focuses on nurturing and developing consumer brands that positively impact society. It provides advisory services, investment, and incubation for mission-driven ventures that feature sustainable business models. One Better Ventures has a notable history of building successful businesses, including Burt’s Bees and Seventh Generation. Currently, the firm collaborates with innovative ventures such as Leesa Sleep and Filter Easy, positioning itself as a principled and patient investor and operating partner. Committed to corporate citizenship, One Better Ventures allocates 10% of its profits to charitable donations and another 10% to an employee bonus pool, reflecting its dedication to service and community engagement.

Founded in 1986, Morningside Group is a venture capital firm based in the greater Boston area. It invests in companies with innovative science and technology across life sciences, digital health, AI, materials, and technology sectors.

Founded in 2012, The Startup Factory is an early-stage venture fund based in Durham, North Carolina. It invests seed capital in exchange for equity, providing mentorship, coaching, and access to a network of active angels and experienced founders through its three-month accelerator program.

UNC Kenan-Flagler Private Equity Fund is a student-run private equity and venture capital firm located in Chapel Hill, North Carolina, established in 2007. The fund focuses on making investments in both early and late-stage companies, engaging in buyouts, growth capital, and mezzanine debt financings. It aims to invest between $0.1 million and $0.15 million in portfolio companies that typically have enterprise values ranging from $20 million to $125 million. The fund operates with the dual purpose of delivering real returns for investors while providing an educational experience for its student members. It collaborates with partner private investment firms to enhance its investment strategies and reach.

Sustainable Food Ventures is a venture capital firm based in Durham, North Carolina, founded in 2020. It invests in early-stage food technology companies worldwide, focusing on cell-based, plant-based, and recombinant food products.

Battery Ventures is a technology-focused investment firm founded in 1983 and based in Boston, Massachusetts. It engages in venture capital and private equity investments in technology companies, with emphasis on software (including application and infrastructure software), IT infrastructure technologies, consumer internet and mobile services, industrial technologies, and life science tools. The firm seeks to back category-defining businesses with potential for scalable growth, often supporting companies through multiple stages and across select global regions.

Alumni Ventures Group is a venture capital firm based in Manchester, New Hampshire, with offices across North America. It provides access to venture investing for individual accredited investors, particularly alumni networks, by offering diversified portfolios of venture opportunities and allowing members to invest alongside fellow alumni in ventures led by peers. The firm backs early-stage and later-stage opportunities across technology, consumer, healthcare, financial services, and other sectors, with a sector- and geography-agnostic approach. It typically invests between $10,000 and $3 million per deal and emphasizes the involvement of alumni connections and an institutional lead investor in opportunities. Alumni Ventures also offers focused funds to broaden participation, enabling accredited investors to access venture portfolios diversified by type, sector, stage, and geography. The model aims to democratize access to venture capital while maintaining rigorous selection standards through alumni networks.

Founded in 2015, Good Growth Capital is a majority women-owned venture capital firm that invests in early-stage companies focused on life sciences, green tech, hard science, and data science. The firm specializes in technology commercialization, sourcing and assessing transformative companies to generate exceptional returns.

Founded in 2020, Piedmont Capital Investments is a venture capital firm based in Raleigh, North Carolina. The firm focuses on investing in transformative companies within the science and technology sectors, with a particular emphasis on electrification, manufacturing, and defense.

RTP Capital Associates is an angel network based in Durham, North Carolina, founded in 2010. The firm is composed of accredited investors who invest their own capital and focuses on seed and early-stage investments. RTP Capital Associates primarily targets companies in technology-centric and low-tech execution-driven sectors within the North Carolina region.

Wilmington Investor Network is a venture capital firm based in Wilmington, North Carolina, founded in 2004. The firm specializes in investing in early-stage companies, particularly in the technology, biotechnology, and medical device sectors. It primarily focuses on businesses located in eastern North and South Carolina, aiming to support local innovation and growth. Wilmington Investor Network typically invests between $0.2 million and $0.5 million in individual investment rounds, leveraging the collective resources and expertise of its network of angel investors to foster the development of promising startups in its target industries.

SJF Ventures is a Durham, North Carolina-based venture capital firm focused on growth- and early-stage investments in cleantech, sustainability, and technology-enabled services across the United States. Founded in 1999, it backs companies with annual sales typically between $2 million and $30 million and enterprise value under $50 million, investing roughly $3 million to $10 million per portfolio company and up to $15 million over the life of a company. It seeks to lead or co-invest in syndicates, sometimes alongside debt with warrants, and aims to take a board seat. Portfolio companies operate in sectors such as energy efficiency, water and waste technologies, renewable energy, sustainable agriculture, health and wellness technology, education technology, and digital services leveraging software and data. The firm pursues rapid sales growth, profitability, and premium exits through strategic mergers, initial public offerings, or buyouts, with a five-year or shorter investment horizon. It maintains offices in San Francisco, New York, and Richmond, in addition to its Durham base.

CFV Ventures is an early-stage venture capital firm established in 2017 and based in Charlotte, North Carolina. It specializes in investing in companies within the fintech sector, focusing on innovative solutions that address the evolving needs of financial technology. As a part of RevTech Labs, CFV Ventures aims to support and foster growth in emerging fintech businesses, providing not just capital but also strategic guidance to help them navigate the complexities of the financial landscape.

Sapphire Ventures is a global software-focused venture capital firm with teams across Austin, London, Menlo Park and San Francisco. It partners with visionary management teams and venture funds to back companies that can become category leaders and has backed hundreds of companies worldwide, generating a track record of public listings and acquisitions. The firm operates a multi-pronged platform—Sapphire Ventures, Sapphire Partners and Sapphire Sport—that combines growth and early-stage investing with a portfolio-growth team providing strategic resources and operational support to help portfolio companies scale. Sapphire Sport is an early-stage investment vehicle focused on the intersection of sport, media and entertainment technology, while the broader platform targets software, cloud, cybersecurity, AI and other technology-enabled sectors.

An Atlanta-based private equity and venture capital firm founded in 1983 that targets early to growth-stage technology and healthcare companies in the United States, with a focus on the Southeast and Georgia. It invests across seed, startup, early and late venture, emerging growth and growth capital, and seeks to take board seats in portfolio companies. The firm focuses on software, information technology, internet security, cloud services, SaaS, data analytics, fintech and payment technologies, as well as healthcare infrastructure, health IT, revenue cycle management, telemedicine and care management platforms. It generally backs companies with roughly $2 million to $20 million in revenue and invests about $6 million to $10 million per deal. Noro-Moseley prefers opportunities headquartered in Georgia and nearby states such as Florida, North Carolina, Texas and others in the Southeast and beyond. It does not invest in pure drug development opportunities.

Starwood Capital Operations, LLC specializes in making direct investments. It makes private equity / buyouts, venture capital, mezzanine, and real estate investing investments in seed/startup companies and is involved in growth capital and buyout transactions. The firm invests in energy infrastructure, oil & gas, hotel and motel construction, homebuilding, hotels, hotel and time share condominium exchange, resorts, public golf courses, golf clubs, gyms and physical fitness facilities, home improvement retail, home furnishing retail, and real estate management and development. It seeks to invest in North Carolina, Virginia, Florida, Michigan, Canada, Brazil, United Kingdom, India, Africa / Middle East, Central America & Mexico, and Caribbean. The firm invests between $5 million and $100 million in its portfolio companies. It invests in companies with sales up to $5000 million. The firm specializes in buyins, asset and financial restructuring. The firm seeks to invest in Global real estate, hotel trade, leisures, and luxury retail. It invests in various property types including multi-family, office, residential, senior housing, commercial land, apartments, mixed-use, distressed real estate, property loan and golf. The firm also invests in products and services related to the hospitality, recreational, luxury lifestyle retail, other industries assets, and can make a mixture of debt and equity investments including distressed debt, value-add, and income assets and corporate opportunities. The firm structures its investments through equity, preferred equity, mezzanine debt, and senior debt. Starwood Capital Operations, LLC was founded in 1991 and is headquartered in Miami, Florida with additional offices across , Asia, Europe, North America, and South America.

Lowe's is a consultancy specializing in the home improvement retail and distribution sector, offering a broad range of job opportunities. The company emphasizes the importance of diversity and inclusion within its workforce, fostering an environment where individuals are encouraged to express their authentic selves and pursue knowledge. Founded in 2016, Lowe's Ventures serves as the corporate venture arm of Lowe's Companies, located in Mooresville, North Carolina. It focuses on investing in seed and early-stage companies that are developing innovative technologies aimed at transforming the future of home improvement. This initiative not only cultivates mutually beneficial relationships within the venturing ecosystem but also acts as a catalyst for innovation and change within the company.

Duke Capital Partners is a venture capital firm based in Durham, North Carolina, founded in 2015. It focuses on investing in consumer, enterprise, and life sciences sectors and supports early-stage companies. The firm operates an associate program that educates the next generation of investment professionals and startup founders.

Founded in 2015, FJ Labs is a New York-based venture capital firm focusing on stage-agnostic investments in marketplaces and consumer-facing startups. Their investment range varies from $50,000 to $5,000,000, typically at seed or series A stages.

Hyperspace Ventures is a software development and venture capital firm that focuses on technology investments and growth capital. The firm backs startups and established brands by funding and developing digital products for scale. It operates primarily in North Carolina, with offices in Chapel Hill and Raleigh, and maintains an additional office in Austin, Texas. It concentrates on technology companies and digital product initiatives, offering investment and development support to help accelerate growth.

Greycroft is a venture capital firm that concentrates on technology start-ups, with a focus on the internet and mobile markets. It operates from offices in New York and Los Angeles, and uses its media and technology industry connections to help portfolio companies gain visibility, build strategic relationships, bring products to market, and grow successful businesses. Founded in 2006, Greycroft has invested in more than 200 companies across sectors such as consumer internet, financial technology, healthcare, and enterprise software, and manages over $1 billion in capital. The firm emphasizes early-stage investing and collaborates with entrepreneurs to support growth, while pursuing diversity initiatives including a diversity term sheet rider.

OSF HealthCare is a not-for-profit Catholic health care system based in Peoria, Illinois, operating a multi-state network in Illinois and Michigan. It provides a wide range of services across hospitals, a medical group, primary and specialty care, behavioral health, and home care through affiliated entities. The system includes multiple acute care facilities and a physician network of more than 600 providers, supported by OSF Saint Francis organization and the OSF Healthcare Foundation. Guided by Catholic values such as justice, compassion, integrity, teamwork, and stewardship, it follows ethical principles in decision making and patient care. Established in 1877, it serves more than 2.5 million people in the communities it serves.

Winston-Salem Partners Roundtable (WSPR) Fund provides seed-stage funding to companies based in, or committed to relocating to, the greater Winston-Salem area. WSPR is looking to invest in companies that have a business model scalable with speed and capital. Typical investment size of $100K – $300K Convertible notes or preferred stock Will lead, co-lead, or follow Board seat: in some cases where WSPR is leading an investment round, WSPR may request a board seat or observer seat.

Bootstrap Advisors is a Durham, North Carolina-based venture partner founded in 2015 by three partners who have collaborated for more than a decade. The firm positions itself as hands-on transformers rather than mere incubators or investors, investing their time and own capital to turn ideas into scalable products and companies. They work with entrepreneurs to develop brands and businesses, leveraging a history of starting multiple ventures, scaling several to multi-million-dollar levels and exiting others to strategic buyers. Bootstrap Advisors seeks opportunities across sectors including B2C, information technology, manufacturing, food technology, and software as a service, with a focus on the Southeast United States. The team emphasizes practical support and active involvement to help early-stage concepts reach market success and growth, combining entrepreneurial experience with a disciplined approach to building sustainable businesses.

Founded in 2000, Southern Capitol Ventures was a venture capital firm based in Raleigh, North Carolina. It focused on early-stage and mid-stage investments in technology companies across the Southeast and Mid-Atlantic regions.

Kapstone Medical is a full service provider that partners with physician inventors and manufacturers of all sizes to develop and commercialize new medical devices. Kapstone Medical offers services for design, prototyping, patenting, quality systems, and regulatory approvals. It provides product development, quality management, and project management solutions to clients who value the knowledge, depth of experience, and resources that a highly capable outsource partner has to offer. Their range of services includes all aspects of product development namely Engineering, Intellectual Property Protection, Quality Assurance, and Supply Chain Management. Kapstone Medical is based in Charlotte, NC, USA and the company was founded in 2007 by John Kapitan.

Southeast Interactive Technology Funds was a venture capital firm established in 1995 and based in Morrisville, North Carolina, with an additional office in Redwood City, California. The firm specialized in investing in early, mid, and late-stage companies primarily within the information technology and communications sectors. Its investment focus included enterprise management and software, Internet infrastructure, telecommunications, and business services. The firm was particularly interested in innovations related to energy applications, advancements in computing efficiency, and ideas that enhanced data utility for businesses and consumers. Southeast Interactive Technology Funds aimed to lead or co-lead initial investments, primarily targeting companies based in the Southeastern United States. The firm was known for its proactive investment approach and strong partnerships with management teams. However, it is now out of business.

Founded in 1987, Canaan Partners is a global venture capital firm based in Menlo Park, California. With over $5 billion under management, the firm invests in early-stage technology and healthcare companies worldwide.

First Launch Capital Fund is a venture firm established in 2018 and located in Greensboro, North Carolina. The firm specializes in seed-stage investments, focusing on entrepreneurs and small businesses with the potential to drive innovation. Its primary objective is to support early-stage technology companies within North Carolina, fostering growth and development in the local entrepreneurial ecosystem. Through its investment strategy, First Launch Capital Fund aims to enhance the culture of innovation in the region by empowering emerging businesses and their founders.

Bioventure Partners is a life science investment company based in Chapel Hill, North Carolina. It specializes in early-stage, technology-driven healthcare startups.

Echo Health Ventures is a venture capital firm that invests in healthcare companies, health technology, insurance technology and digital health in the United States. Based in Seattle with offices in Durham and Portland, the firm is stage-agnostic and aims to accelerate healthcare innovations to scale nationally by offering strategic guidance in addition to capital. Echo Health Ventures focuses on building deep, high-value relationships with portfolio companies to support growth and clinical impact, partnering with startups to advance patient care, improve care delivery, and broaden access to digital health tools.

Established in 2000 and headquartered in Raleigh, North Carolina, Contender Capital is a micro-venture capital firm specializing in investments within the technology sector.

Teall Investments, founded by Ben C. Sutton, Jr. in 2017, is a privately held portfolio of investments in innovative lifestyle brands and services with high growth potential. Headquartered in Winston-Salem, North Carolina, with additional offices in Atlanta and San Francisco, Teall Investments is led by a team of experienced executives. The company focuses on partnering with brands that offer unique market opportunities and have the potential for significant growth in the lifestyle sector.

Malin Corporation plc is an Irish public limited company established in 2015, with its headquarters in Dublin and additional offices in New Haven, Connecticut, and Research Triangle, North Carolina. The company specializes in venture capital investments, focusing on innovative enterprises within the life sciences and healthcare technology sectors, particularly in oncology, immunology, and genetic diseases. Malin's strategy involves the selective application of capital and operational expertise to support private, pre-IPO, and pre-trade sale businesses in rapidly growing markets. By actively engaging with its investee companies, Malin aims to enhance their value propositions and facilitate their journey toward commercial success.

Gray Ventures is a venture capital firm based in Atlanta, Georgia, that has historically invested in early‑stage technology companies in the southeastern United States. It has focused on information technology and B2B software as a service opportunities, with activity centered in Atlanta and the Research Triangle Park region. Typical investments ranged from 0.5 million to 3 million, with a preference for minority stakes and for obtaining a board seat or observer rights. The firm has aimed to be a lead investor while co‑investing with other professional investors, supporting portfolio companies as they progress from seed to Series A funding and scale their operations.